CLUSTAL W (1.83) multiple sequence alignment SgK495_Hsap MKRRA------------------------------------------------------- SgK495_Mmus MKRRA------------------------------------------------------- SgK495_Spur MRNG-------------------------------------------------------- AqueK084_Aque MWAGQPQYYVQPGQPPAHVVAPGQPQAVAASNVTGTPQSQTSTQSSETGGADWAAKAAEW * SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque AKQRQVIELQQQQLMQQQQLQYQYYAQYQQQQQQLQQQQQQLQQQQQYSYNQVGPPVHYA SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque QGYPPPPPSNPHMLSQGSSYPQQLGVVPSPSNQASLLPTPHNPLMTGAAAAAGQSPGSLP SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque QHSLFRPPHNPSAHPSAHMQQQPPPQGTHSQSQGPHPPSQQGSHPQLQGRLSSQQGSHPL SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque PQGSHPLPSQQGSHPSLQGSHLPQGYPSQGGHPPQVSSPYPSSLHDSRPPQGLLPRLPGS SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque RPMLRPPSQGVRPPPHMSPRPGPRAGPPIMRHPPLPRQNQFPAHPHASPSHAPPPSPHDQ SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque HPLCHPSQPLHASPIAASIPLANQTPTRGYASSSSPSPLFYPGNKKPSSREQLVKSSLQT SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque LLHTNTSNDNELKSGKTDDVQLPVIQQDQEVAEQGGVQDELPQEGPEEVASNPIDEHTDD SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque GTLDLVVTTPVNDRKIPGLDLVEGSNKTEQDGEKGGGGEEKQQPQKSQTSNKKSDASDSG SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque TNMIMIQSLGKIVDQLKVLRSAPIKSTNVSSTNISSSTTNMSSKEEEEDDPGYKDTKNKM SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque AALLENESDSDDDEAKASQPHPQRSDDRSQPREDNARDFDGFKGAYGKPPHDWNDTQSLN SgK495_Hsap --------SDRGAG---------------------------------------------- SgK495_Mmus --------SDRGAG---------------------------------------------- SgK495_Spur ------------QG---------------------------------------------- AqueK084_Aque MFTPQEQFTDRGAIHRPPRSFSRSPFHRSLTPPSSYPPHKREPHINPDFEHSGPPRGFDD SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque RPRIPFDEPRSRYPDTDYHSPSSRVPYDSERRSQPRYNEEFDLRPRENMEYERRAAEYER SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque PPQRARDFERSQGPPERSQMIPDYERSRMPPEYERSRMAPDYERSRLPPEYERSQMNPDY SgK495_Hsap ----------------------------------------------------------ET SgK495_Mmus ----------------------------------------------------------ET SgK495_Spur ----------------------------------------------------------PS AqueK084_Aque ERSREYERSRIPPDYERSRMGPDYERSRDYERSRMASDYEQSKRVPDYDRLQMDPAGFER SgK495_Hsap SARAKA------------------------------------------------------ SgK495_Mmus SANAKA------------------------------------------------------ SgK495_Spur K----------------------------------------------------------- AqueK084_Aque SSEAKGYGRDYERPEFFEQDYPAKDYQQVMSDYKSQGVSDYWDNTGSSLLENMQSVDYGH . SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque GKGATESTNTELLQYDALKSYYKQQELGLGGEQVGLLNYALSDLQQKVLPKWLKAELERM SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque ERKKSKEEAMTGGKSSSRSVKSKASSGSKWMEENDEEEEGRERKDIEDVSHNRKRSLSPH SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque TYSSTEISSKHQRLEEDAVEESDHTLKMAFVRRTLTEILLDVTTSEMYSLANEIINKLGD SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque SSNIASDEVSRANLSNPLGLDTLYGSDISDDDLDVGKETGKPSSTKSSLSFQQKSKKSKF SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque TPLDLERMKSGFEESVDQLEKDHHLSDSHKTKKPALLAIDTKQTKKEEWKTGERHHATSH SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque QKSKKSELEAETTRHHPGSIQAISALPVVKKEHSKFDDYHYPSGLGNMRQPTLKIEKVKV SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque NVDERDHFDYSVNIHKSQKSKHSVPTETERVKKESSDECHVSSRSKEQSRSSSSDSKRSR SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque RDDHHFSRSKEQSRSSSSDSKRSRRDDHHFSSDFKQMEAKKEEDFLWEEKERVTGSSQSD SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque GSYERIVMSLDEKKHHKSGKKRDSLSEGRSSKKKDKKRSKSPSSSHHHHKKKKHSSHHHR SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque RSSGDDQSFDDKKKRNSIGSSSVGGSESSGGVSRQSHLFHFEGTRIANQLPLLPNGPLID SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque FRHNRGVYMSSVYNSSSKTSGKRKDYYNNLLKWKTAMASSGTSITTPAIIETEAPTNGGR SgK495_Hsap --------LGSGISGNNAKRAGPFILGPRLGN---SPVPSIVQCLARKDGTDDFYQLKIL SgK495_Mmus --------LGTGIAGNNAKRAGPFVLGPRLGN---SPVPSIVQCLARKDGTDDFYQLKIL SgK495_Spur ----------HAAGGSTLKRAGPYLLGPRLGT---SPVRSIVQCLARKEGTDDFYSLKIL AqueK084_Aque ERRRSSSPFGHLLHLTNGLQSGEYYIGPRLNTVSPSPVKSVSEYIAKKTDGDEFVTMKIL .. ::* : :****.. *** *: : :*:* . *:* :*** SgK495_Hsap TLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHGLFQDRTCEIVEDTESSR SgK495_Mmus TLEERGEQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHGLFQDRTCEAVEDTESGR SgK495_Spur TLSENG---RENQDERQGKMLLHTEYSLLSLLRDQEGVVHHHGLFQDRAYEIRPGTSTSG AqueK084_Aque SLSPGG----NSPEDSQGKSLIHNEHSILSLLQDQIGIIQQHGLYREG------------ :*. * :. :: *** *:*.*:*:****: * *::::***::: SgK495_Hsap MVKKMKKRICLVLDCLCAHDFS--DKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVE SgK495_Mmus MVKKMKKRICLVLDCLCAHDFS--DKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVE SgK495_Spur RKTSYKKRLCLVLDCLVSHDFS--SRTVDLVNLQHHVIHEKKLSEKEAVYIFHDVVSIVE AqueK084_Aque ------NNIILVLDCLYQHEYGSTDQYKDFVNLQQYIIKERRLPEREALQLFYQLVCIVK :.: ****** *::. .: *::***:::*:*::*.*:*:: :*:::* :*: SgK495_Hsap ALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLS SgK495_Mmus ALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLS SgK495_Spur SLHKKNIVHRDLKLGNMVLNCHTRQITLTNFCLGKHLVSEHDLLKDQRGSPAYISPDVLS AqueK084_Aque EIHKKKIVHRDLKLANVVINKRTQQVFLTNFALGKHLVHEDDLLSDQRGSLAYVSPDVIS :*:*:********.*:*:* :*::: :***.****** * ***.***** **:****:* SgK495_Hsap GRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCL SgK495_Mmus GRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCL SgK495_Spur GKPYLGKPSDMWALGVVLFTMLYGQFPFYDSAPQELFRKIKAAEFTIPQDGRVSENTTGL AqueK084_Aque GEPYYGMPSDMWSLGVLLYTMISGQFPYYDDIPQELFRKIKSGKFVLPRDLVISIETQYL *.** * *****:***:*:**: ****:**. *********:.::.:*.* :* :* * SgK495_Hsap IRKLLVLDPQQRLAAADVLEALSAIIASWQSLSSLSGPLQVVPDIDDQMSN--------- SgK495_Mmus IRKLLVLDPQQRLAAADVLEALSAIIASWQSLSSLSGPLQVVPDIDDQMSS--------- SgK495_Spur IKSLLVLDASTRLTATQVIESVKTTLAMWKTMAMQGEHLQVVPDIDNGDNDTPL--AKKP AqueK084_Aque LKELMELDQRKRLTALAAAETTQSILS-RISFTLTREPVQIVPEIVSSPASEFLVPDQDD ::.*: ** **:* . *: .: :: ::: :*:**:* . . SgK495_Hsap ADSSQEAKVTEECSQY----EFENYMRQQLLLAEEKSSIHDARSWVP------------- SgK495_Mmus SDSSQEAKVTEECSQY----EFENYMRQQLLLAEEKSSIHEARAWVP------------- SgK495_Spur SDSSSSSGAASSCSKAVPTADWELKLHQPSQPSPCLTS---YRAPRS------------- AqueK084_Aque YSSTHQVNVTEMSAP-RLHFTMDHQATPQMPIPVERVSPSGLASWLSSSPTTLSPMSPHT .*: . .:. .: : . * : . SgK495_Hsap ------------------------------------------------------------ SgK495_Mmus ------------------------------------------------------------ SgK495_Spur ------------------------------------------------------------ AqueK084_Aque PPLFIYPDNTPSSLPPPPPPSSQFTNPFLHRISPPSSSQSLPLALFHHQPPETNPAPLDM SgK495_Hsap ----------------K-----------------------------------RQFGS--- SgK495_Mmus ----------------K-----------------------------------RQFGS--- SgK495_Spur ----------------P-----------------------------------LSAHR--- AqueK084_Aque PPTHLHNYQQHLHPHSAASHHRHSFSEGDPSSNHWLRRMLTSAPVPVMTHGRRSLGSMAA . SgK495_Hsap -----------------------APPVRRLGHDAQPM-----TSLDTA------------ SgK495_Mmus -----------------------MPPVRRLGHDAQPM-----TSLDTA------------ SgK495_Spur -----------------------HPPVRRLSHDAQPL-----SSAEAA------------ AqueK084_Aque TQEYVIRNRRNSYSQTFGVVGTEGPRVRRRSHEPRDSEREILQNLETAGRFRIGEGSGQQ * *** .*:.: . ::* SgK495_Hsap ---ILAQ-RYLRK SgK495_Mmus ---ILAQ-RYLRK SgK495_Spur ---NFYN--ARSS AqueK084_Aque QQSQFSRSRSSIH : .