CLUSTAL W (1.83) multiple sequence alignment Slob_Hsap MAFMEKPPA-------------GKVL-LDDT------------------------VPLTA CG8726_Dmel MAVFASRYE-------------RKLP-IDDT------------------------QALSC Slob_Dmel MFKFNKAAQ-------------QQ-R-IDNRNSAVTGHDPFVRPPVPEKKVRN----IMK Slob_Mmus MAFMEKPPA-------------GKVL-LDDT------------------------VPLTA SLOB1_Ddis MDSSTANSSGTAISKAEWKPDQSSLECNDCQ------------------------LPFTL SLOB2_Ddis MEYYYYII---------------------------------------------------- Slob_Spur MAVFEKRKS-------------SKLT-LDDT------------------------ITLTC AqueK206_Aque MVFECSSNS--------------T-C-WENCNLVCIGLTA----GGSLIVLVLCIVIITA AqueK207_Aque MMAASASSKKDRSSV-LEKVD-RRLS-VDPT------------------------IPLTA * Slob_Hsap AIEAS-----------------QSL---QSHTEYIIRVQRGISVENSWQIVR--RYSDFD CG8726_Dmel EITAV-----------------QEV---AGHTEYLLRVWRGASNKNYWTVLR--RYNDFD Slob_Dmel KLHKA-----------------NGLKRSNSAIE--FDVS-ALTAANRRQIYSSNRSASSE Slob_Mmus AVEAS-----------------QSL---QSHTEYIIRVQRGISAENSWQIVR--RYSDFD SLOB1_Ddis IRRRHHCRKCGSIFCDSCSSFYSIL---PIEYGYTGQQRLCRSCNNSFEQKK-------- SLOB2_Ddis -IAAV-----------------GGF---AILTFIIIVVLR-------------------- Slob_Spur SIEAA-----------------QNL---ESHTDYVIRVQRGPNPENSWQINR--RYSDFV AqueK206_Aque IVCCC-----------------CCL---YRRRS--RRLRYTPLRDPSGSVVT--TYNPAT AqueK207_Aque TILTY-----------------KIV---QSHVEYVIRVQRGPNPDDSWDVER--RYSDFA . Slob_Hsap LLNNSLQIAGLSLPLPPKKLIGNMDREFIAERQKGLQNY---LNVITTNHILSNCELVKK CG8726_Dmel RLDKSLRVSGIELPLPRKRIFGNMRPEFIAERKQALQEY---INAVLMNPILASSLPAKR Slob_Dmel QDNSDLSEHSEKSPLVSARL-DNLARLFFSKSMPAETGSRDTIDSVLTTR--PNIKYQYS Slob_Mmus LLNNSLQITGLSLPLPPKKLIGNMDREFIAERQRGLQNY---LNVIMANHVLSNCELLKK SLOB1_Ddis ------------------------------------------------------------ SLOB2_Ddis -LKKSQ---KMREPLLPKE-KGN---VFVYKRDTQVQE---------------------- Slob_Spur TLHDGLKVSGMELGLPPKKVFGNMEREFIAERQQALQGY---LNRILSHQLLSSCFLVKR AqueK206_Aque RRNQDIRSGSISDAVAEEGLYEAMQRQR-------------------------------- AqueK207_Aque ALNQALQISGVQVNLPPKRMFGNTDKQFVTERQQGLQEY---LNIIAKHPFIAASLDLKL Slob_Hsap FLDPN-------NYSANYTEIALQQVSMFFR-SEPKWEVVEPLKDIGWR---IRKKYFLM CG8726_Dmel FVDPE-------SYSQSFHDHAVQNAMLCLR-NDTTWSLGGSMGAIGWR---LRKHYFKV Slob_Dmel ALDSGNGIVERSPRERAQREKALNATQEWIQGANGRYEVIAHLDEIGSR---HGKNWFLV Slob_Mmus FLDPN-------NYSANYTEIALQQVSMFFR-SEPKWEVVEPLKDIGWR---IRKKYFLM SLOB1_Ddis ----------------QYFETDALVAQFQLR-STAQFEYSKPLQDIGHTKHGLRKSYCMA SLOB2_Ddis -----------------KEEQVMMNARLYLR-ST-IYSLQDKIPKFGSR---SDKVYFGV Slob_Spur FLDPT-------NYAPNSVEDALQHVSMFFR-SEPHWDVVEPLRDIGWR---IRKTYFMV AqueK206_Aque -----------KERESTRRETGLLNCQFYLR-SNQKYVLETHLPDIGSR---ISKSWFMV AqueK207_Aque FLDPH-------NYSDKCHEIALRNVSMFFR-SNPEWAIVESKKNIGWR---INKHYYLI : :: : :* * : Slob_Hsap KIKNQ--PKERLVLS-------------------------------------WADLGPDK CG8726_Dmel TTKPPEKSSNKQLVKSGSQTHQSKHFAAGSSNGSGHSIDAGTLDPGSEVVAEWLEYGPDK Slob_Dmel TDASVRT---DRLQT---------------------------LLPLPPDCVAFEDLPPNE Slob_Mmus KIKNQ--PKERLVLS-------------------------------------WADLGPDK SLOB1_Ddis KNSMG--GGEECVVS-------------------------------------IITPTPSS SLOB2_Ddis LGNSLNKLENDRIMA-------------------------------------MVPVSKHW Slob_Spur RPKSQ--PKVKQVLA-------------------------------------WSYYGPDK AqueK206_Aque RPISGGQFNPPFLLT---------------------------MSPISQQCRL-NLQGTDK AqueK207_Aque GSKGDG-FKYKRILT-------------------------------------WIEPGPDF : Slob_Hsap ----YLSDKDFQCLIKLLPSC-LHPYIYRVTFAT----ANESSALLIRMFN-EKGTLKDL CG8726_Dmel ----FIDEKEIGGIMKSLMGL-QHPHIEPVLLA----AHTENGCLVIRKFH-KHGTLKDV Slob_Dmel ----CA----REILMELLGSL-HHPYIYPVLDLGFLRNSSYNYACLVTPFN-SRGSLKDL Slob_Mmus ----YLSDKDFQCLIKLLPSC-VHPYIYRVTFAT----ASESSALLIRAFN-EKGTLKDL SLOB1_Ddis CPWSMSNEKKKRKFEKTLLSL-KHPYILTPINVEV--SGANDKILVIRTFF-KQGSLRDQ SLOB2_Ddis -PIPLNSEAGRTTFRTIIKSLEIHPFISVPLLVDF--IPEKHVAVSVRPFYADRGSLRDF Slob_Spur ----DLDYKDLVPIMKLLPTI-QHPFIYPVTYVS----ASDSGGLAIRTFH-GTGTLKDF AqueK206_Aque ----HV----MN-----------------------------------RLF---------R AqueK207_Aque ----CVPERELEYLLKILVDL-KHPNILSPLSAT----YNGTGLLVTREFC-PKGSLRDY * Slob_Hsap IY-KAKPKDPFLKKYCNP----------------KKIQGLELQQIKTYGRQILEVLKFLH CG8726_Dmel LCMAANPKNTFLSKYGNP----------------KGRTALSMKQVATYGKQILEALIFLH Slob_Dmel IY-KAQWNEPWARKYTR------------------KPNGLPVSQVQRLGRQILEALLFLK Slob_Mmus IY-KAKPKDPFLKKYCNP----------------KKTQGLELQQIKTYGRQILEALKFLH SLOB1_Ddis VY-KSKPLSPYDTKYIYKQPKSSSSSSSSSSSSSQSQSVLPIKSIQKYCKQILESLLYLK SLOB2_Ddis IH-KSKPKMPYADKYDT-------------------HLQLNEKIVSKFGRQILEALIFLK Slob_Spur IC-KAKPKAHYLKKYCLP----------------KSYTAFNIMNIKSYGRMILEALKFLH AqueK206_Aque IL-ETTPSLPWSTKYSV------------------RRSGLRTHQIQNFGRQILEAVLFVH AqueK207_Aque MH-KSGPQH-YLKS-CCP------------------TSPLDLGLIKTYGYQVLCVMEYLL : : : . : : :* : :: Slob_Hsap DKGFP-YGHLHASNVML--DGDTCRLLDLENSLLGLPSFYRSYFSQFRKINT-LESVDVH CG8726_Dmel SKGYA-YGHLHSGNIVI--VDDCVKLLDIENFLLGVPAFYRPFFMQHSKIHA-IETIDVY Slob_Dmel ERGFPLHGHLHSGNVIL--QNGAARLSGLENGLLGLSSRINAVMW-SRSVTE-IENVDIV Slob_Mmus DKGFP-YGHLHAANVML--DGNTCRLLDLENSLLGLPSFYRSYFTQFRKINT-LESVDVH SLOB1_Ddis SKGIQ-FSHLHLSNILINQSNDTCQLVDIENCLLGMKPLFNDYIYGIGLPQSFKDNLEVI SLOB2_Ddis NHNFP-YFHLNSANVLV--DDQICLISDYENSFLGLEPRFSDFIRQ---HNE-KIDPDVL Slob_Spur EKGLP-YGHLHAGNVIL--EGNACRLLDIENTLLGLPFFYRGYLSHFRKINT-TEAVDVY AqueK206_Aque ELGFKPFGQIQSGNIYL--EGGRCRVSGIDNAILGYKPRVSRNV----K-TY-KENIDSV AqueK207_Aque SKGFV-LGHITSGNVMII-DYGLCKVSDLENCLAGLPVFHRTFLLELRKVQG-AEAEAVY . . :: .*: : : . :* : * . Slob_Hsap CFGHLLYEMTYGRPPDS-VPVD-------S-FPPAP--SMAVVAVLESTLSCEACKNGMP CG8726_Dmel CFGHVLFEMAMGYPLQES-VVR-------Q-ITEC---PEALKCLLESILSKEACKAGLP Slob_Dmel CFGHLLYEMCTGQELTTPKPSMRVLEMELQHYPQIGQTRKQILEILGLIFE--PPSGVCP Slob_Mmus CFGHLLYEMTYGRPPDS-VPVD-------S-FPPAS--SLAVVAVLESTLSCEACKNGMP SLOB1_Ddis CFGHCLFEMIIGIPLGDHSNIN-------S-FIPLF--PDKVFLLLQQIFS-----EKTP SLOB2_Ddis SFGLVLFEMACGYEMENPHSVD-------ISIPAHC--YPEVRKVLEAIFKP--FYGTPI Slob_Spur SFGHVLYEMTFGSPLNV-ASKD-------D-FPHTI--PPPIKSVLESILTTEACKTKLP AqueK206_Aque MFGHLLFELGSGKELSNPAPIE-------SDYKNVK--NQQVVEVLQFIFQ----SRIPP AqueK207_Aque SFGHLLYEMAYGRILET-ATIE-------A-LPPYPAVDSNLGTLLMSLLSVAG-VKALP ** *:*: * : :* : Slob_Hsap TISRLLQMPLFSDVLL----------TTSEKPQFKIPTKLKEA-LRIAK------ECIEK CG8726_Dmel TLEQLLGHRFFLQYASTESA---GAAANAEKPYFKLSLNAKEL-LKQAA------IKSEN Slob_Dmel SVEDLVLCDLFRSIDLREL----------RGPCFST---IKP------------------ Slob_Mmus TVSRLLQMPLFSDVLL----------TTSEKPQFKIPTKLKEA-LRIAK------ECIEK SLOB1_Ddis TLEELVKNPWFEVTTT----------IE--QQSLQN-GKLKKSQLTFIK------DNSN- SLOB2_Ddis TLEELSKMDFFSYHKFKNLPLHRLTYTSRERDMMDAVIKLNKT-FLSTNSKPNSKDLSQP Slob_Spur TVDDLLADPLFSDVTF----------PERDRPQFRIPSKLKEP-LKAAK------SEVEK AqueK206_Aque TIDEILQLPFFQNAR-TSV----------DNPEGI------------------------- AqueK207_Aque KISDLVSHLFFAGQ-L----------PLTEKPSLKVPSRLKEF-LVSMR------DKVDA .:. : * Slob_Hsap RLIEEQKQI------HQHRRLTRAQSHH------------------GSEEERKKRKILAR CG8726_Dmel RLRDEQKSV------KNQKRIVRVQELM------------------SSEEEKRKSKQKAK Slob_Dmel SLSRST---------------------L------------------NLLQAVKKR-QCAS Slob_Mmus RLTEEQKQI------HQHRRLTRAQSHH------------------GSEEERKRRKILAR SLOB1_Ddis KFESPKVSLSGSFSSSNISKLSSSSSNNNSNNNNNNNNNSNTFNNISSNDDKRKSMK--- SLOB2_Ddis KLKDLKKQ-------KKRKQLVFTQSFE------------------PIKMESQNGGGAAG Slob_Spur RLQEDSRVV------SSFRRLSKAQAHH------------------NSDEEKRRRKKAHL AqueK206_Aque RLDEDI---------------------I------------------ELIQKSRRYRSKGG AqueK207_Aque RLQEDQRKL------SHFLRMSKAHDSL------------------MSEEEKKKRRKKMR : :. Slob_Hsap --------------------------------------------KKSKRS---------- CG8726_Dmel --------------------------------------------LEHKQSK--------- Slob_Dmel --------------------------------------------L--------------- Slob_Mmus --------------------------------------------KKSKRS---------- SLOB1_Ddis --------------------------------------------LPSSTSL--------- SLOB2_Ddis GEYGNEGGYAISTSSSLPSNFLANVKPANSTSYSLLSNTTTNTTNTSTSSSLNSSFN--- Slob_Spur ---------------------------------------------KKRMSE-QN------ AqueK206_Aque --------------------------------------------KGRKAS---------- AqueK207_Aque --------------------------------------------KQMTQEADQTLAEAYP Slob_Hsap --------ALENSE----EHSAKYSNSNNSAGSGASSP------------LTSPSSPTPP CG8726_Dmel ---------LKQQSSIQTN-NGRLSLVAATAAAASSSTTVVGELCGTDSFNRSDSTPEEP Slob_Dmel ----------------------------GHSLSEA------------------------- Slob_Mmus --------AVENSE----EQPVKHSNSNNSAGSGASSP------------LTSPSSPTPP SLOB1_Ddis ---------LNNSF-NLS------NNNNPSSPSTSTIS------------PNSSLISSPP SLOB2_Ddis --------S-NVST-SYS---NATTTTNTTSASSVSPP------------ISSPPPPPPP Slob_Spur --------IGEANN----STPPAQTNG-NHAGNGAV------------------PTPPPP AqueK206_Aque -------------SSTYSN-EG------YYRSSLFSTTPQ-----------VADSTV--T AqueK207_Aque TSKLTKQLSVPSSS-APTNRPSSKASSKTSSASTASTA------------PKSPSTSKSP Slob_Hsap STSGIS-ALPPPPPPPPPP---------AAPLPP-ASTEAPAQLSSQ----AVNGMSRGA CG8726_Dmel TTLAGIKS-PPLTPGPHLGSIYQQELPSTTGAPVERQSSTPNMLSEDAEGGDGDEPTRSA Slob_Dmel ------N-SPCTPPSTP--------HDRR--------T-----------------GVLP- Slob_Mmus STAGLSSALPPPPPPPPPPP--PP----AGPSPT-SATEMPAPFLPQ----PVNGVNRGA SLOB1_Ddis KTPILQTFTPP-PPPPPPK-SAPP------PPPPPSSSKLP-----------PSSSSRNS SLOB2_Ddis PPPSKS-SGPPPPPPPPPKSSGPP------PPPPPKSSPP-----------PPADGSRKG Slob_Spur STPAQPPPVPSAPAPPPPPS--------QGPAPPPVSSNQ--------------PPERGA AqueK206_Aque SSAANESSLPP-PPPPP--------PPSN--------T-----------------NDKSA AqueK207_Aque STTK-SPSTPSVPAPPTTQA--PE------PTPPPA-----------------KTGERGA * .. . Slob_Hsap LLSSIQNFQKG-TLRKAKTCDHSAPK------------IG CG8726_Dmel LLESICKFNRG-SLRKVRSN-------------------D Slob_Dmel --AP----------------YEVFR-------------MY Slob_Mmus LLSSIQNFQKG-TLRKAQTCDHSAPK------------IG SLOB1_Ddis LLESIRNADNAKKLKKTTPNTKPKSSIGPHSLKPSSTKKK SLOB2_Ddis LLSSIESFSSS-KLKKTKTVDKSGPL----------LKKS Slob_Spur LLSSISGFNKG-GLKKTQTADKSGP-------------KV AqueK206_Aque LWSDIHK--GK-TLRPTVTDDRSAP-------------MI AqueK207_Aque LLNSIESFAKG-KLKKTVTKDRSGP-------------FL