CLUSTAL W (1.83) multiple sequence alignment SYK_Hsap MASSGMADS--------------AN-HLPFFFG-----------------NITREEAEDY shark_Dmel MS-----RD--------------SD-PMKWYHG-----------------NLSREAADEL SYK_Mmus MAGSA-VDS--------------AN-HLTYFFG-----------------NITREEAEDY ZAP70_Mmus MP-----DP--------------AA-HLPFFYG-----------------SISRAEAEEH ZAP70_Hsap MP-----DP--------------AA-HLPFFYG-----------------SISRAEAEEH Shark_Spur MSLLGMYPVIVGFRQERGCAFTCCDRRCQFEVG-----------------RATFEKWAEG Syk_Spur MP-----VD--------------PL-SRRFYHG-----------------RITREEAEAR AqueK439_Aque MA-----DL--------------S--NEPWYHG-----------------RISRSDAEQI AqueK440_Aque MAMSNSRDV-----------------ADAWFHG-----------------KITRENAAHL AqueK441_Aque MSPPIVP-----------------V-VRPFFALCEPGTGYALCQSMKLTAPQSRKTYQLR *. : : SYK_Hsap -----------LV-QGGMSDGLYL-----------LRQSRNYLGGFALSVAHGRKAHHYT shark_Dmel -----------LK--QGYEDGTFL-----------VRESSTAAGDFVLSLLCQGEVCHYQ SYK_Mmus -----------LV-QGGMTDGLYL-----------LRQSRNYLGGFALSVAHNRKAHHYT ZAP70_Mmus -----------LK-LAGMADGLFL-----------LRQCLRSLGGYVLSLVHDVRFHHFP ZAP70_Hsap -----------LK-LAGMADGLFL-----------LRQCLRSLGGYVLSLVHDVRFHHFP Shark_Spur -----------VAM--IIEDNLCS-----------PLDARNAEGRTAL------------ Syk_Spur -----------LR-NAGCHQGMFL-----------LRESLGREGNYALSLCYEDDVYHYA AqueK439_Aque -----------LT-QCGGVDGSFL-----------VRDSLTTSGEYVLSLCHQTKRYHYL AqueK440_Aque -----------VTSLPGKLDGYFL-----------VRESLRIPGSFVLTMWADNTVHHFQ AqueK441_Aque IFINAGQNSVCLKKYSGAARNYYFTQLKTDFITGRLQHRMASSGNIALQMAA-------- : . . * .* SYK_Hsap IEREL--NGTYAIAGG---RTHASPADLCHYHSQESDGLVCLLKKPF-NR--PQGVQPKT shark_Dmel VRRHGGEDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPL-IRDLPPHNTRSH SYK_Mmus IEREL--NGTYAISGG---RAHASPADLCHYHSQEPDGLICLLKKPF-NR--PPGVQPKT ZAP70_Mmus IERQL--NGTYAIAGG---KAHCGPAELCQFYSQDPDGLPCNLRKPC-NR--PPGLEPQP ZAP70_Hsap IERQL--NGTYAIAGG---KAHCGPAELCEFYSRDPDGLPCNLRKPC-NR--PSGLEPQP Shark_Spur ------------------------------------------------------------ Syk_Spur IERQY--DGTVAIKDG---KNFAGPIELVSNHMNREDGLLCRLLRPC-NL--QQGIAARA AqueK439_Aque ISRKP--DGTLAIQDG---TKFDSPVDLVRYHGQKIDGLLTTLVYPC-RR--PPGQPPQG AqueK440_Aque IIGHG--DGWFSVDNG---PLFQGLDELIHHYQVKPDGLPKRLLDFVPGQ--PPPLSARK AqueK441_Aque --------------------------------------IDMVLEAV-SHK--PKPLTSYE SYK_Hsap GPFEDLKEN-LIREYVK--QTWN-----------------------LQG----------- shark_Dmel GVTNLLHRA-TSKNESK--VVFEL----LK-CG-----YRNFDAKNQDGQTAL------- SYK_Mmus GPFEDLKEN-LIREYVK--QTWN-----------------------LQG----------- ZAP70_Mmus GVFDCLRDA-MVRDYVR--QTWK-----------------------LEG----------- ZAP70_Hsap GVFDCLRDA-MVRDYVR--QTWK-----------------------LEG----------- Shark_Spur ------------------------------------------------------------ Syk_Spur --FSDMDHQ-QMEGALI--DLAK-----------------------SQGMA--------- AqueK439_Aque YRF--ITHD-EMQQAMR--EGAL-----------------------LLGYQ--------- AqueK440_Aque RVLTNLHKA-VAVNDIK--IVRKY----LS--GPPSLTVGTVDSPNAEGQTPV------- AqueK441_Aque DVLDHFKVSKFLPSYVKSQQAWKKTLSHLFEEY-----YQALSTREPDVIKVQYIYAYEK SYK_Hsap ------------------------------------------------------------ shark_Dmel --------------------------HLAALHSDE--------DILK------------- SYK_Mmus ------------------------------------------------------------ ZAP70_Mmus ------------------------------------------------------------ ZAP70_Hsap ------------------------------------------------------------ Shark_Spur --------------------------HEAAALGEE--------NIIF------------- Syk_Spur ------------------------------------------------------------ AqueK439_Aque ------------------------------------------------------------ AqueK440_Aque --------------------------HEAAKRGYI--------EMVA------------- AqueK441_Aque DIGCGQHLFQAKVYLFPDRPLYEGRIQASWKNGIVMMAATRKEVILMQDIEQIDVSLERL SYK_Hsap ------------------------------------------------------------ shark_Dmel ----HLLNAKVQVNSSDSFGCQPLHYAARSKP-ASFIRTLISA--QANVQGRNIDNGYVP SYK_Mmus ------------------------------------------------------------ ZAP70_Mmus ------------------------------------------------------------ ZAP70_Hsap ------------------------------------------------------------ Shark_Spur ----RLLEKSANINSKDSNGVTPLYTACSSNQ-PRACQFLMQK--GADPTLRHPRTGWVP Syk_Spur ------------------------------------------------------------ AqueK439_Aque ------------------------------------------------------------ AqueK440_Aque ----LLVEHKPDLSLRDSKGSTALHLAAQNGY-ADIIKLLVEN-GKADVQERNTTTGWVA AqueK441_Aque SLSIQLKETAASLNSTSSNSSTGGATDTDSKSQNPITKTLQFKSVEEMI-------SFCS SYK_Hsap --------------------------------------------QALEQAII-SQ--KPQ shark_Dmel LHEAAKHGNLEAVQELLLAEAPPLPRT--SSGEFPFDLAKEAGQTAVEEFLL---NY--- SYK_Mmus --------------------------------------------QALEQAII-SQ--KPQ ZAP70_Mmus --------------------------------------------DALEQAII-SQ--APQ ZAP70_Hsap --------------------------------------------EALEQAII-SQ--APQ Shark_Spur LHEAAMKGHAGCVKELIMHGAPCHPRS--ADNDTPLDLARRYEHSHVVMYLK-SC--KPK Syk_Spur -------------------------------------------PEVITKALHSTQ--RPQ AqueK439_Aque -------------------------------------------EHQINDALL-KR--RSA AqueK440_Aque LHEAAFRGHVDCCKMLLTHNAPLRPRTPSPDEDTPRELANRYKQDKVISLLD-WVAANYP AqueK441_Aque IIDGYYRLKVDINTSILSGDAS-----PADNEHT---------------------KE--- SYK_Hsap LEKLIATTAHEKMPWFHGKISREESEQIVLIGS----------KTNGKFLIRARD-N-NG shark_Dmel ---KLPPANTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESPAAS SYK_Mmus LEKLIATTAHEKMPWFHGNISRDESEQTVLIGS----------KTNGKFLIRARD-N-SG ZAP70_Mmus VEKLIATTAHERMPWYHSSLTREEAERKLYSGQ----------QTDGKFLLRPRK-E-QG ZAP70_Hsap VEKLIATTAHERMPWYHSSLTREEAERKLYSGA----------QTDGKFLLRPRK-E-QG Shark_Spur VP------RLQGKPWFHGSMDRKKALESIQKHG----------AKDGQFLLRSSANK-PD Syk_Spur LERALKKIMHQDKPWFHHKLSREEAEQRIVSAG----------LQEGKFLVRERT-E-EG AqueK439_Aque FEQLVGGILHRRQQWFHGPISRDESELRLRQFG----------LKDGLFLVRERT-Q-VN AqueK440_Aque KP------RTNTSEWLHKVLDRNHAVEYLRQNG----------QVDGSFLVRPNSRK-PG AqueK441_Aque ---TLGK-DIAARDLCHGPISKESANEVFAKQH----------NEEGLYLVRESRTK-DC * : :. : . .* :*:* SYK_Hsap SYALCLLHEGKVLHYRIDKDKT------------GKLSIPEGK----------KFDTLWQ shark_Dmel GLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGP----------YWPSVEH SYK_Mmus SYALCLLHEGKVLHYRIDRDKT------------GKLSIPEGK----------KFDTLWQ ZAP70_Mmus TYALSLVYGKTVYHYLISQDKA------------GKYCIPEGT----------KFDTLWQ ZAP70_Hsap TYALSLIYGKTVYHYLISQDKA------------GKYCIPEGT----------KFDTLWQ Shark_Spur TMVLSMAANGTVFNFEINTK-M------------ESFYIDDGP----------YFDTLEQ Syk_Spur SFALSLCYNNFVYHYKIDKDCT------------GQLSIKEGP----------KFDSLIQ AqueK439_Aque SFALCISFKMKIYHYLLDMNTL------------GQLSIENGR----------KFENLLQ AqueK440_Aque YYALTLVYKQMPFHYEIICESD------------RWYYIDDGP----------LFDSISL AqueK441_Aque TFILSLCQKEGVFNYRISKDYD------------HRFALVDTTGISPVPRSVNSCHTLND * : :: : : : .: SYK_Hsap LVEHYSYKADGLLRVLTVPCQKIGTQGNVN--FGGRPQLP-------GSHPATWS----- shark_Dmel LIAHFMRFSYGLPVSLKYPVPPQPKPEVPSFA--TIPRS--------NMKP--------- SYK_Mmus LVEHYSYKPDGLLRVLTVPCQKIGAQM-------GHPGSP-------NAHPVTWS----- ZAP70_Mmus LVEYLKLKADGLIYRLKEVCPNSSASAA-----VAAPTLP--------AHPSTFT----- ZAP70_Hsap LVEYLKLKADGLIYCLKEACPNSSASNA-S--GAAAPTLP--------AHPSTLT----- Shark_Spur LIDHYSRYDDGLPTMLLHPIPPPPGRIDNGPPTREKPS-P-------APRPVDLT----- Syk_Spur MVDHYQLKKDGLLCCLLVPCHDNNRDTP-T--RRRHSGSQSIHVDDVHEYDAYADRNQRR AqueK439_Aque VVDHYSRTPDGLLCSLGDYCPVRGFEESK---GKSAPRVR-------------------- AqueK440_Aque CVDHYMMFADGLPTILRHPIAPIDNRICRTLSK--APP-P-------GQ----LL----- AqueK441_Aque LILHHHHFADGLPILLKQNCPPSKTGPM-----PLFPETP-------------------- : : ** * . SYK_Hsap ------------AGGIISRIKSYSFP----KPGHR-KSSPAQG----------NRQ---- shark_Dmel -----------------KAA-SPATPPTPVSP-HSHHQHPHVPAL--TITKKKQKEN--- SYK_Mmus ------------PGGIISRIKSYSFP----KPGHK-KPAPPQG----------SRP---- ZAP70_Mmus -----------------------------------------QP----------QRR---- ZAP70_Hsap -----------------------------------------HP----------QRR---- Shark_Spur ------------AHR-VTPV-RRDSPEPPLSPIEREGSIPMSPPPELPSG---RAPKSNA Syk_Spur IASEDGGGVPPTPLRTALSV-SVSSPPGIRAPLEY-NPSPPTP----------NRT---- AqueK439_Aque ------------------------------------------------------------ AqueK440_Aque ------------FSQ-SQPL-HHTRPPLPTPP-SRQSSRPPAPLP--PMG---NAPALNG AqueK441_Aque --------------------------NTPT----AVT----------------------- SYK_Hsap ------------------------------------------------------------ shark_Dmel SSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLKSL SYK_Mmus ------------------------------------------------------------ ZAP70_Mmus ------------------------------------------------------------ ZAP70_Hsap ------------------------------------------------------------ Shark_Spur FSKI-------------------------------------------------------- Syk_Spur ------------------------------------------------------------ AqueK439_Aque ------------------------------------------------------------ AqueK440_Aque IP-S-------------------------------------------------------- AqueK441_Aque ------------------------------------------------------------ SYK_Hsap -----ESTVSFNPYEPEL-APWAAD-KG-PQ---RE------------------------ shark_Dmel SFSTEFSTFNADGVTGSG-AAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVA SYK_Mmus -----ESTVSFNPYEPTG-GPWGPD-RG-LQ---RE------------------------ ZAP70_Mmus -----VDTLNSDGYTPEP-ARLASS-TD--K---PR------------------------ ZAP70_Hsap -----IDTLNSDGYTPEP-ARIT-S-PD--K---PR------------------------ Shark_Spur -----FGGIRASEKT------KRKD-KE-MD---RQ------------------------ Syk_Spur -----NSSNNVNDLHLTQMGGHGWD-E--PE---HE-GE--------------------- AqueK439_Aque ------------------------------------------------------------ AqueK440_Aque -----FKTVSANSSS-------------------PS------------------------ AqueK441_Aque ------------------------------------------------------------ SYK_Hsap ---------------------------------------------ALPMDTE-------V shark_Dmel IERERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTESEMASYLHRKCSGT SYK_Mmus ---------------------------------------------ALPMDTE-------V ZAP70_Mmus ---------------------------------------------PMPMDTS-------V ZAP70_Hsap ---------------------------------------------PMPMDTS-------V Shark_Spur ---------------------------------------------RKELQKA-------I Syk_Spur -------------------------T-------------------SIEEFVL-------V AqueK439_Aque ------------------------------------------------------------ AqueK440_Aque ---------------------------------------------SLSGPAS-------R AqueK441_Aque ---------------------------------------------VMPPPEE-------E SYK_Hsap YESPYAD-PEEIRPK-----------------------EVYLDRKLLTLEDKELGSGNFG shark_Dmel PSTPSAT-EVEAAKL-----------------------RFFIEPEKL-VLDREIGHGEFG SYK_Mmus YESPYAD-PEEIRPK-----------------------EVYLDRSLLTLEDNELGSGNFG ZAP70_Mmus YESPYSD-PEELKDK-----------------------KLFLKRENLLVADIELGCGNFG ZAP70_Hsap YESPYSD-PEELKDK-----------------------KLFLKRDNLLIADIELGCGNFG Shark_Spur HEAPGGG-SDEV---------------------------QCIDASLI-ERGNEIGQGEFG Syk_Spur EELPSQR-PREYHDDDDKIYGVANEQEKLYDYLAKTKTTKKLDATCL-NQGDQIGKGNFG AqueK439_Aque -----HG-PR------------------------------RIEDSEL-ETQGELGAGTFG AqueK440_Aque SHQPHQD-PYSM---------------------------VYIQEKSL-SLGPELGQGEFG AqueK441_Aque LDSPIIQELVQAGVR-----------------------RIHYRRELT-V-LKELG----- ::* SYK_Hsap TVKKGYYQMKK-----VVKTVAVKI--LKNEA-NDPALKDELLAEANVMQQLDNPYIVRM shark_Dmel SVHSGWLLRKSGAGEESRLEVAIKM--LSDE----HSNKQEFLREASVMMRLEHKCIVRL SYK_Mmus TVKKGYYQMKK-----VVKTVAVKI--LKNEA-NDPALKDELLAEANVMQQLDNPYIVRM ZAP70_Mmus SVRQGVYRMRK-----KQIDVAIKV--LKQGT--EKADKDEMMREAQIMHQLDNPYIVRL ZAP70_Hsap SVRQGVYRMRK-----KQIDVAIKV--LKQGT--EKADTEEMMREAQIMHQLDNPYIVRL Shark_Spur SVLEGKYKEKD-----RWVKVALKT--LHADH--LQTGQKEFLREAKVMCGLDHPCIVKL Syk_Spur SVLKGTCMANG-----QLIPVAVKT--LKADF-GIPNSEPEIVREAELMAGLDHPHIVRM AqueK439_Aque TVRQGVYRPLSG---EPPVKCALKF--LKPTE-ELPNQKAEILREADAMAMLDHPNIVRL AqueK440_Aque SVLRGTYRMPD----GKSVDVAVKT--LRVDA--MGHGEKEFLREAKIMMGLHHPGIVQL AqueK441_Aque -------------------SVAIKIPTFPQQTSKAQVVLDEMKREILTMYQLDHQYITTL *:* : *: * * *.: *. : SYK_Hsap IGICEAE--------SWMLVMEMAELGPLNKYLQQNR-HVK-------------DKNIIE shark_Dmel IGIAKGE--------MLMMVQELAPLGSMLQYILDHGHEI-TA-----------NAELKV SYK_Mmus IGICEAE--------SWMLVMEMAELGPLNKYLQQNR-HIK-------------DKNIIE ZAP70_Mmus IGVCQAE--------ALMLVMEMAGGGPLHKFLLGKKEEIP-------------VSNVAE ZAP70_Hsap IGVCQAE--------ALMLVMEMAGGGPLHKFLVGKREEIP-------------VSNVAE Shark_Spur MGVCLGP--------PMMLVQELVSQGALLDFLQND--SIT-------------ASDLKL Syk_Spur IGICHAA--------EMMLVLELAELGPLHKYLKKHQ-EMS-------------TRNVLE AqueK439_Aque YGICVGD--------PIRLVMELAACGPLNKFLRKHV-GFP-------------VLKIVN AqueK440_Aque IGVTKNK--------PLMLVQELVPCGALVDYLYDGK-YPKPE-----------IMTLKL AqueK441_Aque LGVADERHILDTIGRFPMIVMEFIDGGSLRGILNDFR-PSRLQPRPIKPPPSDWEVRYLR *: :* *: *.: : SYK_Hsap LVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGK shark_Dmel WASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGR SYK_Mmus LVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGK ZAP70_Mmus LLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK ZAP70_Hsap LLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK Shark_Spur WATQIASGMMYLEGKKFVHRDLAARNILLENKGQAKISDFGLSRATGANNDYYRSTTGGR Syk_Spur LMYQVAQGMCYLESRQFVHRDLAARNVLLVDETFAKISDFGMSKALGLDSQYYVAETAGK AqueK439_Aque MIIQVAKGMEYLEKTRFVHRDLAARNVLVVDDDNVKISDFGMSRAIGGGSEYYRAETAGR AqueK440_Aque WAAEIASGMMYLEKKRFVHRDLAARNILVASSYVVKISDFGLSRAVGANSDYYKASQGGR AqueK441_Aque YSQQIAEGMDYLGSRNVVHRDLATRNVLVVSDQHVKIADFGLARQFMENRDYYRSTKRTD ::: ** ** ..******:**:*: .**:***::: . * SYK_Hsap WPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK-GERMG shark_Dmel WPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDS-GERLP SYK_Mmus WPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK-GERMG ZAP70_Mmus WPLKWYAPECINFRKFSSRSDVWSYGVTMWEAFSYGQKPYKKMKGPEVLDFIKQ-GKRME ZAP70_Hsap WPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ-GKRME Shark_Spur WPVKWYAPESIYYGTFSHSSDVWGFGVTLWEMNSRGAQPYGEKTGAEVIKQIEN-GHRLN Syk_Spur WPLKWYAPECIYKFKFSSKSDVWSYGVTLWEALSYGKRPYASMRGQELMQFIEN-GDRLS AqueK439_Aque WPLKWYAPECIYYAKFDSKSDVWSYGVTAWEAFSYGAKPYQGMRGTDIMQMLEG-NERLD AqueK440_Aque WPVKWYAPESINYGTFSHASDVWSYGVTLWEMFSYGEPPYGEMTGAEVLDFIENRNGRLD AqueK441_Aque LPVYWYAPECLIELNFKPASDVWSFGVTLWEIFTLGRRPQEFLEHVVMQA--Q-ADPRHG *: *****.: *. ****.:** ** : * * . . * SYK_Hsap CP----------------------AGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNY- shark_Dmel QP----------------------NLCPAYIYAVMQSCWKERPKDRPTFVYLTEFFARDP SYK_Mmus CP----------------------AGCPREMYDLMNLCWTYDVENRPGFTAVELRLRNY- ZAP70_Mmus CP----------------------PECPPEMYALMSDCWIYKWEDRPDFLTVEQRMRNY- ZAP70_Hsap CP----------------------PECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC- Shark_Spur RP----------------------EGCPQNVYQIMNKCWSYKPCNRPTFSQLNDMFRDDP Syk_Spur QP----------------------DRCPDDVYSLMRRCWLSEAKDRPGFGDIESVLSDI- AqueK439_Aque RP----------------------DKCPQAIYEIMLRCWSWRPEDRPSFGELVSTISEIA AqueK440_Aque RP----------------------PTCPLPIYHLMLNCWSLETNQRPTFAELYDFFNKSD AqueK441_Aque HPLQAVRKKRRETHTKLYNNRLPNIGIPDQIYRMLKETWHIDPSRRPTFSHLSDKLSRQL * * :* :: * ** * : : SYK_Hsap -YYDV---------------------------VN shark_Dmel DYQNLP--------------------ELVQTVHI SYK_Mmus -YYDV---------------------------VN ZAP70_Mmus -YYSLASRAEGP----------PQCEQVAEAACG ZAP70_Hsap -YYSLASKVEGP----------PGSTQKAEAACA Shark_Spur EYGAFYH-----------------RGVHNPPSRR Syk_Spur -LKRLQA-----------------GTLRMRTDRQ AqueK439_Aque QFHMTQSPLSRPPMRPPRPGHNPGLPPGTPPRRM AqueK440_Aque D---IPH-----------------KELYQNPGKL AqueK441_Aque LLF------------------------QATSATS