CLUSTAL W (1.83) multiple sequence alignment TBCK_Hsap -------MFPLK----------------D------------------------------- C33F10.2_Cele -------MGSFP------------------------------------------------ CG4041_Dmel -------MGTRER-------------ERE------------------------------- TBCK_Mmus -------MFPLK----------------D------------------------------- TBCK_Ddis -------MMKSDEGVSGNSNNNNNYKFKDNTFRKYGVEVVAYDNNNNNNNNNNNNDDNNT TBCK_Spur EPSVTLAMQPFG----------------D------------------------------- * TBCK_Hsap ---------AEMGAFTFFASAL----PHDVCGSNGLP----------------------- C33F10.2_Cele ----------NFGAFILRAQEK----DGRTC-INGLP----------------------- CG4041_Dmel ---------CRLCAVTFFAKLH----PGDVCGSNGLP----------------------- TBCK_Mmus ---------AEMGAFTFFASAL----PHDVCGSNGLP----------------------- TBCK_Ddis VTVNSRGFHISIHPFSFRNKLTINQNNGSIGGSSSSSSTSNSVSTPKPQSFYVDDAGIAK TBCK_Spur ---------AEIGVSTFYASRY----ANDQCGADGLP----------------------- : : . .. . TBCK_Hsap -LTPNSIKILGRFQILKTITHPRLCQYVDI--SRGKHERLVVVAEHCERSLEDLL----R C33F10.2_Cele -VASPAKQMLGRFPYLQSLQHDNLSVYLHFSETVIARDLVIVVMEHYTMNLEDIL----K CG4041_Dmel -LTPNSIAILGRAQKLKELQDEHLCQYLDV--IRGKHERTIVVSEYLGLSLEDYA----M TBCK_Mmus -LTPNSIKILGRFQILKTITHPRLCQYVDI--SRGKHERLVVVAEHCERSLEDLL----R TBCK_Ddis QLNQSVFDILSRSRYLSSLSHENLAEFIAAEPSQKHHDQMLIVSEDYKNSLEKQIEIQAK TBCK_Spur -LTPSSIKIVGRFQELRVLHHPRLCQYLDA--VRGKHERLIIVAEHYSNNLGLEA----K : ::.* * : . .*. :: :: ::* * .* TBCK_Hsap ERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLD-RKG---HIKLAKFGLYH C33F10.2_Cele TGNLKDESLNNNFYSEISSALDYLHTRNIVHGFLHLNSIYITDRKNQKLSVKLSGYGLPF CG4041_Dmel RHPPLAIAQILRIFYQVACGINVLSRHHLVAHNVEPKHILLS-SDGQ--RVKLFNYGLHH TBCK_Mmus ERKPVSHSTVLCIAYEVLEGLHYLNKHGIVHRALSPHNILLD-RKG---HIKLAKFGLYH TBCK_Ddis RQTPIPSNTIGRYAYQILKALSYLHSQDLTHRSLSLDNIKLD-DNN---QIKLTNYGLYY TBCK_Spur KGTFKDPGQILPIIHQTLEGLSFMHKYGLVHRGLSPSNILLN-PEG---HVKLAKFGLYH : .: : :. : * : .. :** :** . TBCK_Hsap MTAHGDDVDFPIGYPSYLAPEVIAQGIFKTTD-------HMPSKKPLPSGPKSDVWSLGI C33F10.2_Cele LTNYGKDTASSIKFGAFLAPERILNDE----------------DSLFAATYQSDVWELGF CG4041_Dmel MTKGGAYVPFPIGNIRYMAPERLL---------------------GLNGNVKSDVWSLAL TBCK_Mmus MTAHGDDVDFPIGYPSYLAPEVIAQGIPKTTD-------HVPSEKPLPSGPKSDVWSLGI TBCK_Ddis LSDHGENVSFPIGNLLYLSPESILRGA------------------KGSSNTKADVWALGC TBCK_Spur ITNCGSDVPFPIGHPRYMAPEVLTPGPMLPTNGDTPTTPLPPKTTNLSSGPKGDVWSLGM :: * . .* :::** : . :.*** *. TBCK_Hsap ILFELCVGRKLFQSLDISERLKFLLTLDC---VDD-TLIVLAEE---------------- C33F10.2_Cele IILQIYLGISLEAEVTETEYLEILNKY---YTDDQEKLSTVMED---------------- CG4041_Dmel VMVELILQIELWPKLKLSNVVRKILAFGK---SNG-ALEKIARE---------------- TBCK_Mmus ILFELCVGRKLFQSLDVSERVKFLLTLGC---VDD-TIIVLAEE---------------- TBCK_Ddis ILLHICLGYCIWQDNNPSIVTNRILHLSGYSTT-Q-SFNSISKSFEQCELKKTIINEKQH TBCK_Spur VILELCLGQTLWPVATLPQILAKVMLLGKHGAQKH-PLDTILDEH------------AGQ ::..: : : . : : : . TBCK_Hsap ------------------------------------------------------------ C33F10.2_Cele ----------------LIQLLA-------------------------------------- CG4041_Dmel ------------------------------------------------------------ TBCK_Mmus ------------------------------------------------------------ TBCK_Ddis EEYEEY------------------------------------------------------ TBCK_Spur QKLDAYPASLQSFLRKCLSASPLERPSTTELLESDMLKDMKPSELLPPSSLTMFRYQGLR TBCK_Hsap ------------------------------------------------------------ C33F10.2_Cele ----------------D------------------------------------------- CG4041_Dmel ------------------------------------------------------------ TBCK_Mmus ------------------------------------------------------------ TBCK_Ddis ------DDDEDISEEEKEKRIKDIKLNNRDN----------------------------- TBCK_Spur CKDLELDTDQDDASQEGEDCLPSVESTKGSFRYDAAKLLQVLYDDGHVKLAKFGLYHITN TBCK_Hsap ------------------------------------------------------------ C33F10.2_Cele ------------------------------------------------------------ CG4041_Dmel ------------------------------------------------------------ TBCK_Mmus ------------------------------------------------------------ TBCK_Ddis ------------------------------------------------------------ TBCK_Spur CGSDVPFPIGHPRYMAPEVLTPGPMLPTNGDTPTMPLPPKTTNLSSGPKGDVWSLGMVIL TBCK_Hsap ----------------------------------------HG-------------CLDII C33F10.2_Cele ----------------------------------------KK-------------RLPY- CG4041_Dmel ----------------------------------------HQ-------------CHERY TBCK_Mmus ----------------------------------------HG-------------CLDII TBCK_Ddis -----------------------------MNNFINSLKREEKENSDSNSGSSNSNIGIGL TBCK_Spur ELCLGQTLWPVATLPQILAKVMLLGKHGAQNHPLDTILDEHA-------------GRQKL . TBCK_Hsap KELPETVIDLLNKCLTFHPSKRPTPDQLMKDKVFSEVS-PLY--------TPFTKPASLF C33F10.2_Cele HKKCEWLEAIIRKCLQMCCSKRCSITEVAAE-----IEI----N-----INGVKNNNNKY CG4041_Dmel VQMDQRLRQLLESCLSVLPKRRPLPGELLEHPIFEEVLLDLKKQKM----QPLSPETEHL TBCK_Mmus KELPENVINILKKCLTFHPSKRPTPDELMKDQVFSEVS-PLY--------TPFIKPASLF TBCK_Ddis NGLGKELIEIIEQCLIPNPMDRPDSETLLDHPYFNEYK-NIDPYQLQWIIKPFTKSWDL- TBCK_Spur DAYPASLQSFLRKCLSASPLERPSTTELLEGDMLKDMK-PSE---L----LPPSSLTMFR : ::..** * : TBCK_Hsap SSSLRCADLTLPEDISQLCKD--INN--------DYLAERSIEEVYYLWCLAGGDLEKEL C33F10.2_Cele EY--KV--KTVEEMRAAVRKEVADNN--------DGFEKLSVENSFYLWKTCGSTPEIIL CG4041_Dmel PLLLR----------------------------------CPLSQIYHLWQLAGGDVQAEL TBCK_Mmus SSSLRCADLTLPEDISDLCKD--IDN--------DYLAERSIEEVYYLWCLAGGDLEKEL TBCK_Ddis PDSLESLTLKEIESYGHIGSD--NNGGGGGGGGESDSDIYSGKEIYYFWKLLGGNIEKEL TBCK_Spur YQGLRCKDLELDTDQDDASQE--DDE--------DHMAQRPMKEVYYLWTLAGGDLEGEL . . .: :::* *. : * TBCK_Hsap VNKEIIRSKPPICTLPNFLFEDG---ESFGQGRDRSSLLDD------------------- C33F10.2_Cele LKKGIIQNHAPISSYPTVRFDDF---LRLDSGVDSQSTFEY------------------- CG4041_Dmel KKEGLIRSEAPILGLPQIVRLSG---ASVCPGRSQAQLMDD------------------- TBCK_Mmus INKEIIRSKPPVCTLPNFLFEDG---ESFGQGRDRSSLLDD------------------- TBCK_Ddis VNKGFAKASPSVHKLPLYVPVKASLTESTNSGLNSPQPYQHQHHQHQHQHQHPNIIKSKN TBCK_Spur RKKGLLRSQPPLCALANIVTDDG---DMHGKERDTSSLNDD------------------- :: : : ..: . . . . : TBCK_Hsap --------TTVTLSL--CQLRNR---LKDVGGEAFYPL--LEDDQ-SNLPHSNSNNELSA C33F10.2_Cele --------GVFDLPS--KKTLTRKETGQRVSARMFHKIGILEDKD---LLNGNILYET-- CG4041_Dmel --------RVVPLRL--KALLQR---LSGLPAAVYFPL--LHSPR-F--PAH-FAREL-- TBCK_Mmus --------TTVTLSL--CQLRNR---LKDVGGEAFYPL--LEDDQ-SNLPHSNSNNELSA TBCK_Ddis STVYNNEFCLVELSNVFLKIKES---FKLYGSKVFEEG--IEQSN-N--NNNNRFNN--- TBCK_Spur --------TVVILSL--EQLKKR---LENIEEEAYYPL--LGDDPNEGLPTSQSSSDLSQ . * . : : . : TBCK_Hsap AATLPLIIREKDTEYQLNRIILFDRLLKAYP-Y-----KKNQIWKEARVDIPPLMRGLTW C33F10.2_Cele ----------------ASNMLTVDHLLNASAVFG----ISSIISRLTNIGVIPTQRADVW CG4041_Dmel -QELPLVIREKDIEYQFQRVRLFARLLQGYP-H-----TAEQLQREAAVDVPPLLRGPIW TBCK_Mmus AATLPLIIRERDTEYQLNRIILFDRLLKAYP-Y-----KKNQIWKEARVDIPPLMRGLTW TBCK_Ddis --------IENNIELQIIIIREFHKLLYQYQ-YDDPTLSQPKIYRLAKLFVPPILRGDIW TBCK_Spur GASLPLVIRERDIEYQFHRVVLFDRLLKGYP-F-----TIGRIWKEARIDIPTMYRDETW : . :** . : : : : : . * * TBCK_Hsap AALLGVEG-------------------------------------------------AIH C33F10.2_Cele CTLLDINE-------------------------------------------------TKW CG4041_Dmel AALLEVV---------------------------------------------------PN TBCK_Mmus AALLGVEG-------------------------------------------------AIH TBCK_Ddis SSILGVNER------------------------------------------------EAK TBCK_Spur AALLGVEEVIIITYHVLKREGGEPVNREGDLEVDGIIGKGRPKISWKDVVKKEGSKGDIQ .::* : TBCK_Hsap AKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVS-H-PDLVYW C33F10.2_Cele RDYLNLDVLASHSSDRQLEVDIPRCHQYDSYMTTPAIQESLRKVLKGWQIVTESQHFVYW CG4041_Dmel GSYAKIDKFTSTSTDRQIEVDIPRCHQYDELLSSPDGHRKLRRLLKAWVTA-H-PQYVYW TBCK_Mmus AKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVS-H-PDLVYW TBCK_Ddis QLYNSINLDVKGPNDKQFELDIPRCHQYHPLLSSRQGHVQLFKILKAWSLL-NLEKGCYW TBCK_Spur ANYDAIDKETPTAMDRQIEVDIPRCHQYNELLSSVVAHNKFKRILKAWVVS-H-PELTYW * :: . . *:*:*:********. ::: : .: ::**.* . . ** TBCK_Hsap QGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHD C33F10.2_Cele QGCDSLATPFLLANMSKPHVAFACFKEFTYRYCHKFYLKDNSEVIKEYLGIFYHLVAYTD CG4041_Dmel QGLDSLTAPFLYLNFNNEELAFLSLFKFIPKYLQWFFLKDNSAVIKEYLSKFSQLTAFHE TBCK_Mmus QGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHD TBCK_Ddis QGLDNVASPFLVHHFFNEPIAFASLKAFVDKYLSILYVPNNHAALSEIMLIYQQLLAYHD TBCK_Spur QGLDSLCAPFLYLNFSNEALAYACLKAFIPKYLYKFFMKDNSLVIQEYLAVFSHMIAFHD ** *.: :*** :: : :*: .: * :* ::: :* .:.* : : :: *: : TBCK_Hsap PELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQ C33F10.2_Cele PVLYKHLKINGFDAELFAIPWFLTCFAHELPLSKLVLLWDETMMHGNAFPLMIALAMLNR CG4041_Dmel PLLAQHLASISFIPELFAIPWFLTMFSHVFPLHKILHLWDKLMLGDSSYPLFIGIAILRQ TBCK_Mmus PELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQ TBCK_Ddis PELLNHLMDIQLDPNLYSIPWFITVFAHILPIDKLEILWDSILLCPSSLPNFIAASMIIQ TBCK_Spur PELSNHLQSIGFIPELFAIPWFLTMFSHVFPLHKIFHLWDTLLLGTSSFPLCIGVAILQQ * * :** : .:*::****:* *:* :*: *: *** :: .: * *. ::: : TBCK_Hsap LRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSG C33F10.2_Cele LRDKLLAVNFNEMIIIIHDQPDLSIDEIIKNSRGYEKLIPPSCTFRAHASPWKG------ CG4041_Dmel LRSTLLTSGFNECILLFSDLPDIVMDGCVLESQKMYEATPKSITHRQHALRLQP------ TBCK_Mmus LRDRLLANGFNECILLFSDLPEIDIERCVRESVNLFCWTPKSATYRQHAQPPKPASESSV TBCK_Ddis FRDSILKMNFEDGITMMSMIPSVDVHKCVSDALSMFNKTPLSTTVTKFVSNTD------- TBCK_Spur LRVGLLMAGFNECILLFSDMPEIDIEKCVRESIRLFCNTPKSATYRKYAHPPKKVDRITA :* :* .*:: * :: *.: :. : :: * * * .. . TBCK_Hsap GRS--SAPYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTP C33F10.2_Cele ------------------------TSLSLQQLSSIHCPRMSSEELIWRI----------- CG4041_Dmel ----------------PQALDIGVADVELKHLQQEQCPRISAKDVQFLLD---------- TBCK_Mmus VRS--SAPYFSAECTDPPKTDLSRESIPLSDLKSEVSPRISAEDLIDLCELTVTGHFKTP TBCK_Ddis ------------------QELWWMQEVPFEKRKLELFPRIDIHDLIN------------- TBCK_Spur TSQIKPVSYYSTDSNDMPRSELSREALSQKDLKEEVAPRISAEDLLELCDLHGSNSSHSP : .. . **:. .:: TBCK_Hsap SKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGK C33F10.2_Cele ------ERKMVYVLDTRQESEFQSERFSDSFNHPNNNHEADIDWL---RFLPGIVCSELP CG4041_Dmel -----NSPAELALIDLRSVVEFGRVHVPHSINIPFATVQLGEQRLEALQVPQLEAQLRGK TBCK_Mmus TKKTKSSKPKLLVVDIRNSEDFVRGHIAGSINIPFSAAFTAEGELSQGPYTTMLHNFKGK TBCK_Ddis -------DQQKVILDIRTPLQFQQIHYPSSINVNPKLSK----------LQQQMEQYKGQ TBCK_Spur TKKNKNSKPIILIVDIRSSDDFSRGHIPSSVNTPFNSAFSPEGDLIPCPAVTQLYNHRGR ::* * :* : . *.* . TBCK_Hsap VIVIVGHVAKHTAEFAA---------------------HLVKMKYPRICILDGGINKIKP C33F10.2_Cele KCFVYGKNDKEAAER--------------------LTEAYVMKGVPYICLLHDHFEAVRN CG4041_Dmel IVVCVSNIHQHSVEVGHPLAQLKLLCKLKSFPISQFSHFLVACGVQRTCILHKGFNVLHS TBCK_Mmus VIVVVGHVAKQTAEFAA---------------------HLVKMKYPRVCILDGGINKIRP TBCK_Ddis QIVVIAPK-DQGVDFTN---------------------QLIQWKFPFVSMLNGGMDSLEH TBCK_Spur VVTVVGHKGKNAPN---------------------------------VSMMSC------- . .. : .:: TBCK_Hsap -TGLLTIPSPQI C33F10.2_Cele -RDSVV---VKP CG4041_Dmel -IEPNI--LISN TBCK_Mmus -TGLLTVPSPQI TBCK_Ddis GAHSLLIISNKN TBCK_Spur -REDIL--LHEY .