CLUSTAL W (1.83) multiple sequence alignment TTK_Hsap MESEDLSGRE-LTIDS-------------------------------IMNK--------- MPS1_Scer MSTNSFH-DY-VDL-------------------------------KSRTN--TRQFSDDE CG7643_Dmel MTTPVPRR---------------------------------------------------- TTK_Mmus MEAEELIGSS-VTIDS-------------------------------IMSK--------- TtkA_Ddis MDTHQSFNEN-QHPNFNSG--------------------N-----HGGIN--MNRFQRFS TTK_Spur MTYHTECMSE-LARHGNKPCEWLAYLSLVESHTVHAEETSRYRFLSLAFNRATKQIPIDK CC1G_03033_Ccin MSTSPSISPP-RTPNDNRP--------------------T-----ASTSN--SP-SSDDS TTK_a_Smoe EELHSLRS---------------------------------------------------- TTK_b_Smoe ------------------------------------------------------------ GK068_Glam MFGAPGSVPKDGDPPADR----------------------GYRPMRGYFNW--------- TTK_Hsap --------------------VRDIKNKFK-NEDLT--DEL--S---LNKISADTTDN--S MPS1_Scer EFTTPP------------------------------------K---LSNFGSALLSHTEK CG7643_Dmel --------------------TKDMMALGL-DSDSE--DDF--NTPY-------------- TTK_Mmus --------------------MRDIKNKI--NEDCT--DEL--S---LSKICA---DH--T TtkA_Ddis KPTISP----------IQQQQQPQP---------Q--QPS--S---IIQRQSIIMTQPQP TTK_Spur YCEDPAYARIIIKLAHLKA-SREEMAQMM-NGNTR--DNTTGNLTSLARFH-SMTDH--T CC1G_03033_Ccin SIIDDL------------------------------------S---FDYV----YDD--N TTK_a_Smoe ------------------------------------------------------------ TTK_b_Smoe ------------------------------------------------------------ GK068_Glam --------------------TRDIAKEVPTTPDATEGDQE--E---SSS---SLADT--K TTK_Hsap GTV-----NQIMMMANN---PE--DWLSLL-LKLEKN---SVPLSDALLNKLI-GRYSQA MPS1_Scer TSA-----SEILSSHNN----D--KIANRL-EEMDRSSSRSHP-PPSMGNLTS-GHTSTS CG7643_Dmel ----------------R---PR-----QAA-A---------------------GERKQQP TTK_Mmus ETV-----NQIMRVGNT---PE--NWLNFL-LKLEKN---SSPLNDDLLNKLI-GRYSQA TtkA_Ddis QPQ-----PQMIPIFRE---PN--EWYKLIDMEMNKFNNESRP-SPEYIKYLT-QLFQQA TTK_Spur ECM-----SELARHGNK---PC--EWLAYL-SLVESH---TVHAEETSRYRFLSLAFNRA CC1G_03033_Ccin GNV-----VRLSRKSNSTSPPT--DQESLP-DSALDN---DSPAGSPLNRQSL-SRSESA TTK_a_Smoe ------------------------------------------------------------ TTK_b_Smoe ------------------------------------------------------------ GK068_Glam ACVTPVGQNEVRGVAH---PPKPSHLQRQH-SSVQHV---VAPLKKEAENTVI-KKSPIF TTK_Hsap IEALPPD-KYGQNES--------------------------------------------- MPS1_Scer SHST-------------------------------------------------------- CG7643_Dmel VASFQVQTRGKENEPHPL-P---------------------------------------- TTK_Mmus IEVLPPD-KYGQNES--------------------------------------------- TtkA_Ddis LDSL-------------------------------------------------------- TTK_Spur TKQIPID-KYCEDPA--------------------------------------------- CC1G_03033_Ccin QSILQG-TSAAATDPKPARPFQRVASTPSYLLPTAAATSRAAVTRGGPRRIIEDSHNRER TTK_a_Smoe ------------------------------------------------------------ TTK_b_Smoe ------------------------------------------------------------ GK068_Glam LE-EPPQ-KKLNYAS--------------------------------------------- TTK_Hsap ------------------------FARIQVRFAE-LKAIQEPDDARD-YFQMARANCKKF MPS1_Scer --------------L--------FG--------------------------RYLRNNHQT CG7643_Dmel ------------------------INMLPRRVSE-LTMMDSDSDEED-IKSNHNLNCAIL TTK_Mmus ------------------------FARIQVRLAE-LKAIQEPDDARD-YFQMARENCKKF TtkA_Ddis --------------EHKNT--PEFYLFLLN-RATFQSKIGENEDAKG-TLKYMKVLKMES TTK_Spur ------------------------YARIIIKLAH-LKATHDVDDGRM-MFKFARANVRKQ CC1G_03033_Ccin QEPIVRSRQTFDYATRDSYAHQEEKENI---LAEM-DERPQLVNRRNSPPLIARSTASRF TTK_a_Smoe ------------------------------------------------------------ TTK_b_Smoe ------------------------------------------------------------ GK068_Glam ------------------------YSTSSKRSS--------------------------- TTK_Hsap AFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPL----EMLEIALRNLNLQKKQ----- MPS1_Scer SMTTMNTSDIEINVGN------SLDKSFE----R-------------------------- CG7643_Dmel NDSFVLSPSQELTNSNSNIT-----TRRTPSAAP-------------------------- TTK_Mmus AFVHVSFAQFELSQGNLKKSEQLLHKAVETGAVPL----QMLETAMRNLHLQKKQ----- TtkA_Ddis FEVFVLLSEIESKSFRFSKARSIINRGIQKIPSRS----KEFEGFLMVIDIQEDEFSRNG TTK_Spur AIVHLEAAKFEEIHGDMKKCLGILEKGFKVTSDPR-----LSEALHRV-KNGLPI----- CC1G_03033_Ccin SSARISYSTIGGSLNGRPLADVPVQRTARQPPTGLTRPGRLMKSSLTSL-----KYS--- TTK_a_Smoe ------------------------------------------------------------ TTK_b_Smoe ------------------------------------------------------------ GK068_Glam -----------------------NDQSTKRSASPQ----TIDTAATKVLGLTQQ------ TTK_Hsap --------------------------------LLSE--------EEKKNLSA-STVLTAQ MPS1_Scer ------------------------------IRNLRQNM-KEDITAK-------------- CG7643_Dmel ---------------------------------LKQSD-SNLSF---------------- TTK_Mmus --------------------------------LLPE--------EDKKSVSA-STVLSAQ TtkA_Ddis CIISNNNNISFNNGDVNNNSIIMNENDQPMVINLNPQQ-QQQQQQQPYEISSSSSL--MS TTK_Spur --------------------------------LLDSQE-PMESQDGPQTMSA-APA-PVQ CC1G_03033_Ccin --TSNQDRLSDVV-----------ESSDYE-----------HKQQGLPEPNPYAPPASDT TTK_a_Smoe ------------------------------------QQ-QEVKVAEGANV---------- TTK_b_Smoe ------------------------------------------------------------ GK068_Glam ---------M--------------------T-ILDNKEFQYNKTLGSTEVKSETKVVVAT TTK_Hsap ES-------FSG----------------------------------------------SL MPS1_Scer ------YAERRSKRFLI-SNR-----------------------TTKLGPAKRAMTLT-- CG7643_Dmel -----------------------------------------------------------L TTK_Mmus EP-------FSS----------------------------------------------SL TtkA_Ddis TPASSRHLSNRSSIVPT-PNS-----------------------STKLSESIKTIGLRSV TTK_Spur PS----HNASEEKISPHVPSSMEYVDTTISFR------------------------RPEV CC1G_03033_Ccin EPED-------EPLE---PSA-IPLRSSLNPRQRKELNINAQAASLAQSGSNRPR--RSA TTK_a_Smoe ----------HDKVV---TES-----------------------K--------------- TTK_b_Smoe ------------------------------------------------------------ GK068_Glam TP-------PSEVLTPLVPTSS-----------------------TPQSAAVQKK----- TTK_Hsap GHLQNRNNSCDSRGQTTKARFLYGE----NMP-PQDAEIGYRNSLRQ--TNKTKQSCPFG MPS1_Scer -----------------------NIF-DEDVPN--------------------------- CG7643_Dmel GRFNDMGINCSSQGSP-------------------------------------------- TTK_Mmus GNVQNRSISCESRGQAGAARVLYGE----NLP-PQDAEVRHQNPFKQ--THAAKRSCPFG TtkA_Ddis QPRRVIHKQTTTNFNTTTTTIPENSY-DDDADQPMDHDGNNNNNFRIHSNNNNNSSANSS TTK_Spur GSRISSHPKCDSDHESDTMPINAGS----RFSGLQTPDVANKFGVFG--SSRRKRSGNIG CC1G_03033_Ccin SLSDALYPHDDYQLQVAAPPTHGHSRPGTS------------LGLNAES--GPRR----V TTK_a_Smoe ------------------------------------------------------------ TTK_b_Smoe ------------------------------------------------------------ GK068_Glam -------------------------------------------------PSQSLRKGIFG TTK_Hsap ---RVPVNLLNSP-----------------DCDVKTDDSV------------------V- MPS1_Scer -----------SPNQPINARETVELPL--EDSHQTNFKERREN----------------- CG7643_Dmel ------------------------------------------------------------ TTK_Mmus ---RVPVNLLNSP-----------------DFYVKTDSSA------------------V- TtkA_Ddis YNK----SENDEDDQDEED---EEEEDEDEDDDEEDEEEYEDNNNNNNNNNNNNNNNNNN TTK_Spur MPMRVSRTSLPQL---KKE---SKDDDDDDDDDDDDDDDI------------------RP CC1G_03033_Ccin YPEERERQELEAHKKLRRE---HEDDRQS-----------------PSPTHGHPQHQR-- TTK_a_Smoe ------------------------------------------------------------ TTK_b_Smoe ------------------------------------------------------------ GK068_Glam ---QTDINYNTTI-----------------DFQ--------------------------- TTK_Hsap ------------------------------------------------------------ MPS1_Scer -TDYDSI-DFGDLNPIQYIK----KHNLPT------------------------------ CG7643_Dmel ------------------------------------------------------------ TTK_Mmus ------------------------------------------------------------ TtkA_Ddis NNNNNNN-NYFKYNRQQYIL----NNDSDT------------------------------ TTK_Spur LKCSPQETKPGPLAPI-----TEKTNESDSGVQTTPRDLTQTDRNPFTFKERTIEMGAES CC1G_03033_Ccin -----------------LVANGHRRRDSD------------------------------- TTK_a_Smoe --------------------------ESD------------------------------- TTK_b_Smoe ------------------------------------------------------------ GK068_Glam ------------------------SGDAANT----------------------------- TTK_Hsap ------------------------------------------PCFMKRQTSRSECRDLVV MPS1_Scer ----------------------------------SDLPL--------------------- CG7643_Dmel -----VANSEKQVAKKTAPTLQ-AAPSATERRPLQETETPLRNELPSTSKTK-PDADFIT TTK_Mmus ------------------------------------------TQLTTRKGSG-PDRDAIL TtkA_Ddis ----------------------------------STNPN--------------------- TTK_Spur TVPGQLANSMQRH-DPLMSVQQMAHPQMPVQPQWQQQ--QPQHSVPQMSMPH-VDVQRMQ CC1G_03033_Ccin ------------------------------------------------------------ TTK_a_Smoe ------------------------------------------------------------ TTK_b_Smoe ------------------------------------------------------------ GK068_Glam NIP--LPPVTGQVLEK-LPTKQVVYPCAPQVPDL-------------------------- TTK_Hsap PGSKP-----SGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKTESSLLA MPS1_Scer ------------------------------------------------------------ CG7643_Dmel PQVRTIGSTLAGKSRSAVSNDFRAQKVLFQTPMTVS-RAAPV-ASDSISFS--LCDTI-- TTK_Mmus PGSRP-----RGSDSYELRGLKPIQTIYLKDSLVSNEKSSEL-MSDLIALKSKTDSS-LT TtkA_Ddis ------------------------------SPASSNSSVNDIINSISITDDSKLDYENNV TTK_Spur PLQ----------------------QQL-------------------------------- CC1G_03033_Ccin --------------------------------------------------TLR------G TTK_a_Smoe --------------------------------------------------SSR------G TTK_b_Smoe ------------------------------------------------------------ GK068_Glam ------------------------------------------------------------ TTK_Hsap KL-EETKEYQEPEVPE------SNQKQWQSKRKSECIN--------QNP----AAS-SNH MPS1_Scer ---ISQIYFDKQRE-E-----NRQAAL-RKHSSRELLYKSRSSSSSLSS----NNLLANK CG7643_Dmel --------TESPDIPEPPKKAEPPKSQHPSKKSLDHVF--------RES----D-----K TTK_Mmus KL-EETK----PEIAE------RRPMQWQSTRKPECVF--------QNP----AAF-APL TtkA_Ddis KL-QQQQQQQQQQQ-Q-----QQQQQQ-QQQQQQQYIQQQQQQQPKIHP----QRF-SLQ TTK_Spur -------------------------------------F--------QQ------------ CC1G_03033_Ccin -LAPPN----------------SA---------GTVGSPTVMDMPNGRPSPTGHRF-PHG TTK_a_Smoe ------------------------------------------------------------ TTK_b_Smoe ------------------------------------------------------------ GK068_Glam -----------------------------------------------QP----VNTGSQQ TTK_Hsap WQIPELARKVNTEQKHTTFEQPVFS---VSKQSPPISTSKWFDPKSICKTPSSNTLDDYM MPS1_Scer DN---------SITS----NNGSQP---RRKVSTGSSSS--------------KSSIEIR CG7643_Dmel DNVPD-----------------KVD---------------NVEPKE-------------- TTK_Mmus RHVPDVTPK-------------------ADKESPPISVPKWLDPKSACETPSSSSLDDYM TtkA_Ddis NNTPTTTT---TTTAATNVQNPSSS---SSYISPPLSSQ--------------SSELQHQ TTK_Spur ---P------------------TPA---------------GMQPNY-------------- CC1G_03033_Ccin RSSPAATV--------RGRQSPQTV---KGRVSPPATKGR-------------VSPANAG TTK_a_Smoe ------------------------------------------------------------ TTK_b_Smoe ------------------------------------------------------------ GK068_Glam YRIPMVSLTSQ-NVTYTTSNQPTMAGESRAAITAPSTRQ--------------NSDGTVA TTK_Hsap SC--FRTPVVKNDFPPACQ-LSTPYGQ--------------------------------- MPS1_Scer RA--LKENIDTSNNSNFNS-PIHKIYKGISRNKDSDSEKRE------VLRN------ISI CG7643_Dmel ------------------------------------------------------------ TTK_Mmus KC--FKTPVVKNDFPPACP-SSTPYSQ--------------------------------- TtkA_Ddis RR--HSIQAQRANKPPVIP-PPSKLHQNNLQQQQQQQQQQQQQQQQQQQQQLLLQQQALL TTK_Spur ------------------------------------------------------------ CC1G_03033_Ccin NRLGVSRDAGKHRRSPTAPEPPTTSGQIGGHEQPPGSKTWGGSEREDEFDPASSGEK-DR TTK_a_Smoe ------------------------------------------------------------ TTK_b_Smoe ------------------------------------------------------------ GK068_Glam RV--HDIDD--PDYTKAL------------------------------------------ TTK_Hsap ----------------PACFQQQQHQI----------------------LATPLQNLQ-- MPS1_Scer -NANHADNLLQQENKRLKRSL--------DDAITNENINSKNL-EVFYHR--PAPKPPVT CG7643_Dmel --------------------------L----------------------VSIPAVAVP-- TTK_Mmus ----------------LARLQQQQQQG----------------------LSTPLQSLQ-- TtkA_Ddis QQQQQQQILLQQQQQQQQQQQ--------QQQQQQKQ-QEQQLKKTNMQP--PPPKQPQP TTK_Spur --------------------------Q----------------------LPAPQMVAP-- CC1G_03033_Ccin EKERERQ-LEAQRERRERREQQQQQQPPPQPPPQQLQ-PYAQVPQAIAQPAAPAPQPP-- TTK_a_Smoe ------------------------------------------------------------ TTK_b_Smoe ------------------------------------------------------------ GK068_Glam -------------------------KF----------------------LEKYMSSLA-- TTK_Hsap --------------------VLA--SSSANECISVKGRIYSILKQIGSGGSSKVFQVLNE MPS1_Scer KK-----------VEIVEPAKSA-SLSNNRNIITVNDSQYEKIELLGRGGSSRVYKVKGS CG7643_Dmel --------------------PEQ-PSHKTSNILKIKNHEYTIDKKLGCGGSSSVFLARRS TTK_Mmus --------------------ISG--SSSINECISVNGRIYSILKQIGSGGSSKVFQVLNE TtkA_Ddis QTQTQQQQKNINNSEIVDKEKSFEVAKSWSEVAMVNGKPYLRIEFIGKGGSGKVYKVLSG TTK_Spur --------------------V---PQPKSKNLIQVNGKGYSIIRLIGKGGSSKVFQVLSE CC1G_03033_Ccin --------------------IPA--PNQLNRHIVVNKKAYARIDIIGKGGSSRVFRVLNH TTK_a_Smoe ------------------------KTRENANFVWVNNKRYQKLGKIGSGGSSHVFKVIAQ TTK_b_Smoe -------------------------------FVWVNNKRYQKLGKIGSGGSSHVFKVIAQ GK068_Glam --------------------LLF--RKIPVQILYINKKVHLVIEQIGAGGYGHVYKALQP :: : :* ** . *: . TTK_Hsap K-KQIYAIKYVNLEEA-------DNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEIT--- MPS1_Scer G-NRVYALKRVSFDAF-------DDSSIDGFKGEIELLEKLKDQ-KRVIQLLDYEMGD-- CG7643_Dmel DSGNEFALKVVDLQ-A-------DPQVVQGYLNETKLLAKLQGN-VCVVALYDYQLVRE- TTK_Mmus K-KQINAIKYVNLEDA-------DSQTIESYRNEIAFLNKLQQHSDKIIRLYDYEIT--- TtkA_Ddis D-LKIYALKYVCLS---------DPNEIEAQLNEIEMLKRLRKQ-VNIIQLIDYEVNMA- TTK_Spur DSKKLWALKYVKLDFA-------DEMAMQSYMNEITLLARLKTF-KRIIHLHDYELT--- CC1G_03033_Ccin A-NELYAIKRVSLDKT-------DAETMSGYMNEIALLKRLEGN-SRIIRLIDSEVKPGP TTK_a_Smoe D-CTIYALKRIILKGR-------DHQTACGFHQEIEYLERLKGK-NHIIQLIDYEVTDKT TTK_b_Smoe D-CTIYGLKRIILKGR-------DHQTACGFHQEIEYLERLKGK-NHIIQLIDYEVTDKT GK068_Glam S-GKLCAIKLLWSQKGNNYNEKEEKTNYKAMIDEIEIMKRLKGK-GICLDLVDCQVVTKH .:* : . : . * : :*. : * * :: TTK_Hsap ---------------DQYIYMVMECGNIDLNSWLKKKKS---------------IDPWER MPS1_Scer ----------------GLLYLIMECGDHDLSQILNQRSGM-P------------LDFNFV CG7643_Dmel ---------------ESKLYMVMEKGDCDLNKILQSYTTN--------------LPLYSL TTK_Mmus ---------------EQYIYMVMECGNIDLNSWLKKKKS---------------INPWER TtkA_Ddis ---------------KNYILLVLEFGEIDLSKLLQRLQTPNG------------TNVNFI TTK_Spur ---------------EDYIYLVMECGSIDLATFLKKNKDN--------------LSPHHM CC1G_03033_Ccin ------------GGSKGHLLLVMECGEIDLAKLLQEQMKE-P------------LNMVWV TTK_a_Smoe IFRSDSAAAHGEILNDVRIYMVLEYGEIDLARILERKKSEDGQ-----------LDENWL TTK_b_Smoe IFRSDSAATHGEILNDVRIYMVLEYGEIDLARILERKKSEDGQ-----------LDENWL GK068_Glam N----------P-FLRRYALIVMELGDTDLRSFMKEFKSVKRDRVVGPLHPCNLLPESKI :::* *. ** :: TTK_Hsap KSYW-----------------KNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGI MPS1_Scer RFYT-----------------KEMLLCIKVVHDAGIVHSDLKPANFVLVKGILKIIDFGI CG7643_Dmel MNIL-----------------YQMLQAVNYIHQHGVIHSDLKPANFLMVSGRLKLIDFGI TTK_Mmus KSYW-----------------KNMLEAVHIIHQHGIVHSDLKPANFVIVDGMLKLIDFGI TtkA_Ddis RIYW-----------------QQMLQAVHTIHEEKIIHGDLKPANFVSVQGSLKLIDFGI TTK_Spur WCYW-----------------QEMLEAVDVIHKEGIVHSDLKPANFIFVEASLKLIDFGI CC1G_03033_Ccin SYYW-----------------QQMLQAVHVIHEEKIVHSDLKPANFVLVKGQLKLIDFGI TTK_a_Smoe RLHW-----------------EHILKAVNTIHEERIVHADLKPANFLLVQGALKLIDFGI TTK_b_Smoe RLHWEVKHSSSSSSFKLVFHSQHILKAVNTIHEERIVHADLKPANFLLVQGALKLIDFGI GK068_Glam LSLL-----------------YDMITVLHRMHMQGYIHCDLKPQNFMFYKGRLRLIDFGI .:: :. :* :* **** **: .. *::***** TTK_Hsap ANQMQP-DTTSVVKDSQVGTVNYMPPEAIKDMSSSR-----ENGKSKSKISPKSDVWSLG MPS1_Scer ANAVPE-HTVNIYRETQIGTPNYMAPEALVAMNYTQN-SENQHEGNKWKVGRPSDMWSCG CG7643_Dmel ASNIAV-DSTSIIKFSQAGTFNYISPEALTDTSTGNSP-MRRADQPKIKISTKSDVWSLG TTK_Mmus ANQMQP-DTTSIVKDSQVGTVNYMAPEAIRDMSSSR-----ENSKIRTKVSPRSDVWSLG TtkA_Ddis AKAIQSDDTTNIVRESQIGTINYISPEALIDTSQG-------GPKQCMKLGRASDIWSLG TTK_Spur ANAIQN-DHTSVVKESQVGTLNYMSPEAIQDTSPVNEVNEYGHKKPRLKINCKSDVWSLG CC1G_03033_Ccin ANAIAN-DTTNIQRDHQIGTVNYMSPEAIELPD----------GMRRLKVGRPSDVWSLG TTK_a_Smoe AKAIQN-DTTNIVRESQVGTLNYMSPEAFLMNSR--------DEQGTVKCGRASDIWSLG TTK_b_Smoe AKAIQN-DTTNIVRESQVGTLNYMSPEAFLMNSR--------DEQGTVKCGRASDIWSLG GK068_Glam SKAMQQ-DTTCAVTDTIAGTPKYMAPEIMLTIGRT-------MDNKKTELHRVADVWSIG :. : . . ** :*:.** : . : :*:** * TTK_Hsap CILYYMTYGKTPFQQI-------------------------------------------- MPS1_Scer CIIYQMIYGKPPYGSF-------------------------------------------- CG7643_Dmel CILYLLLYQKTPFGHI-------------------------------------------- TTK_Mmus CILYYMTYGRTPFQHI-------------------------------------------- TtkA_Ddis CILYEMAFGYPPFKSF-------------------------------------------- TTK_Spur CILYSMVYGRTPFQHIVHRLLKMQAICNPDHFIDFQPIENELLLDVMKINCKSDVWSLGC CC1G_03033_Ccin IILYQMVYGHPPFQHL-------------------------------------------- TTK_a_Smoe CILYQMVYGRTPFSHL-------------------------------------------- TTK_b_Smoe CILYQMVYGRTPFSHL-------------------------------------------- GK068_Glam CILFEMAAGYHPLDRYVDN----------------------------------------- *:: : * TTK_Hsap ---------------INQISKLHAIIDPNHEIEFPDIP---------------------- MPS1_Scer ---------------Q-GQNRLLAIMNPDVKIPFPEHTSNNE------------------ CG7643_Dmel ---------------RNVYAKMSAITTPGTSIEYPAIPPY-------------------- TTK_Mmus ---------------INQVSKLHAIINPAHEIEFPEIS---------------------- TtkA_Ddis ---------------SNIISKYQAIINPHHKIEFPVHP---------------------- TTK_Spur ILYSMVYGRTPFQHIVHRLLKMQAICNPDHFIDFQPIE---------------------- CC1G_03033_Ccin ---------------S-VYQKMKAIPDLSHVIEYPEYTVPSIPAKTSSNGTVEPPKRLEH TTK_a_Smoe ---------------S-FYQKIREITNENHVINFPPVS---------------------- TTK_b_Smoe ---------------S-FYQKIREITNENHVINFPPVS---------------------- GK068_Glam ----------------HPLALLNTVAEKRYVIEADDLH---------------------- : * TTK_Hsap -----EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPV---N---QMAKGTTEEM MPS1_Scer ---KIPKSAIELMKACLYRNPDKRWTVDKVLSSTFLQPFMISGS------I--------- CG7643_Dmel ----YPIMLVHMAKNCLQLNPKKRPSCTELLQYPFHMIIPLQN---L---QI-------- TTK_Mmus -----EKDLRDVLKCCLVRNPKERISIPELLTHPYVQIQPHPG---S---QMARGATDEM TtkA_Ddis -----NENLLKVLKLCLIRNPHERPTIPTLLNHDFLK----------------------- TTK_Spur -----NELLLDVMKKCLTRDVKRRPSIEELLNHPYVKKPFPAAE--K---STASLTTEHI CC1G_03033_Ccin LKRRVRADVIRGIKSCLCRNPKERATIPELLEQPWLGLTGNEPEPVRPRIEDMLGEKETL TTK_a_Smoe -----NPLIVDVMKSCLMWDKDKRPRIPQLLEHAFLKPRPPPPP------DDHHYLREAL TTK_b_Smoe -----NPLIVDVMKSCLMWDKDKRPRIPQLLEHAFLKPRPPPPS------DDHHYLREAL GK068_Glam ----VSPELRELILLCLEHSPKDRITMEGIFAHACLKNQFSQN-------E--------- ** . . * :: TTK_Hsap KYVLGQLV--GLNSPNSILK-------AAKTLYEHYSGGESHNSSS-------------- MPS1_Scer ------------------------MEDLIRNAVRYGSEKPHISQDDLNDVVD-------- CG7643_Dmel ------------------------------------------------------------ TTK_Mmus KYVLGQLV--GLNSPNSILK-------TAKTLYERYNCGEGQDSSS-------------- TtkA_Ddis ------------------------------------------------------------ TTK_Spur SALVSQLSQSQINSPRSIAR-------LAQGVVEQISRGQQIDISS-----AVKGNAQQQ CC1G_03033_Ccin ---IN---------PYYMAQ-------LMQYCVKLAREDKPMDAET-L-QKD-------- TTK_a_Smoe ---LESF------QAYVSARGSMELTELIRKAIK-----PPLDG--GHEMLD-------- TTK_b_Smoe ---LESF------QAYVLARGSMELTELIRKAIK-----PPLDG--GHEKLD-------- GK068_Glam ------------------------------------------------------------ TTK_Hsap ------------------------------------------------------------ MPS1_Scer ------------------------------------------------------------ CG7643_Dmel ------------------------------------------------------------ TTK_Mmus ------------------------------------------------------------ TtkA_Ddis ------------------------------------------------------------ TTK_Spur QIPQAPSQYQYPHQPHPQPHAHQHQHHHQQGQVSGHDGGYRSQQRAPLRVINSSDMASHH CC1G_03033_Ccin ------------------------------------------------------------ TTK_a_Smoe ------------------------------------------------------------ TTK_b_Smoe ------------------------------------------------------------ GK068_Glam ------------------------------------------------------------ TTK_Hsap --------------SKTF-----------EKKRGKK MPS1_Scer TVLRKF-------------------------ADYKI CG7643_Dmel -----------------P-----------SRTANSN TTK_Mmus --------------SKTF-----------DKKRERK TtkA_Ddis -----------------------------------I TTK_Spur SLLKPLSLAPKYDISSSQ-----------ENGQMNT CC1G_03033_Ccin AEV-----------RELV-----------VPMLADN TTK_a_Smoe EVLLPF--------ARLYVKRAGKAALCELLTSVTM TTK_b_Smoe EVLLPF--------ARLYVKRVGKAALCELLTSVTM GK068_Glam -----------------------------VSEFQRS