CLUSTAL W (1.83) multiple sequence alignment TIE2_Hsap MDSLASLVLCGVSLLLSGTVE-GAMDLILINSLPLVSDAETSLTCIAS----GWRPH--- TIE1_Hsap MVWRVPPFLLP-ILFLASHVG-AAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWG TIE1_Mmus MVWWGSSLLLP-TLFLASHVG-ASVDLTLLANLRITDPQRFFLTCVSGEAGAGRSSD--- TIE2_Mmus MDSLAGLVLCGVSLLLYGVVE-GAMDLILINSLPLVSDAETSLTCIAS----GWHPH--- Tie_Spur MGWIRGPCLLLFALIIAQYSRTNGEEIVIINSTPLVTGAVTRLVCLDA---SGQLSA--- * * *:: . :: :: . :. *.*: . * . TIE2_Hsap EPITIGRDFEALMN-QHQDPLEVTQDVTREWAKKVV-WKREKASKINGAYFCEGRVRGEA TIE1_Hsap PPLLLEKDDRIVRT-PPGPPLRLARNGS----HQVTLRGFSKPSDLVGVFSCVGGAGARR TIE1_Mmus PPLLLEKDDRIVRTFPPGQPLYLARNGS----HQVTLRGFSKPSDLVGVFSCVGGAGARR TIE2_Mmus EPITIGRDFEALMN-QHQDPLEVTQDVTREWAKKVV-WKREKASKINGAYFCEGRVRGQA Tie_Spur DELSVQKVLPADEGL----PVPAAPSLVDPG-HLVADWNASWADSRYGVYSCHGLDE--A : : : *: : . : *. . ... *.: * * TIE2_Hsap IRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKE-EDAVIYKNGSF--IHSVPR TIE1_Hsap TRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQ-TDVIWKSNGSY--FYTLDW TIE1_Mmus TRVLYVHNSPGAHLFPDKVTHTVNKGDTAVLSAHVHKEKQ-TDVIWKNNGSY--FNTLDW TIE2_Mmus IRIRTMKMRQQASFLPATLTMTVDRGDNVNISFKKVLIKE-EDAVIYKNGSF--IHSVPR Tie_Spur HKVMTVKINRDAQIKPEHFTMTASPGDNITITMQITTRTRTPDYLIWAHDELPLPYNATR :: :: * : * .* *.. **. :: : .. * : :.. . TIE2_Hsap HEVPD-ILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTA TIE1_Hsap HEAQDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPG TIE1_Mmus QEADDGRFQLQLQNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCVKDCPG TIE2_Mmus HEVPD-ILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPDCSRPCTT Tie_Spur FGFKD---RYSIPAVGQEDAGIYQA-YPPDDPTQGGYMRLIVRGCPAERWGTGCTNECPT * : . .:*:*.* * . ..: ***** * * :**. * . *. TIE2_Hsap CMNNGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYG TIE1_Hsap CLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYG TIE1_Mmus CLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGTAGCRGLTFCLPDPYG TIE2_Mmus CKNNGVCHEDTGECICPPGFMGRTCEKACEPHTFGRTCKERCSGPEGCKSYVFCLPDPYG Tie_Spur CSNGGECDDVTGVCVCPPGFHGDTCEIGCGANLYGSSCEHMCTGN-SCEHMQFCLPDPYG * :.* *.: * *:***** * ** .* :* :*:. *.* .*. ******** TIE2_Hsap CSCATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIQ TIE1_Hsap CSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDR- TIE1_Mmus CSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDR- TIE2_Mmus CSCATGWRGLQCNEACPSGYYGPDCKLRCHCTNEEICDRFQGCLCSQGWQGLQCEKEGRP Tie_Spur CSCATGFAGLACDEACPDGHYGAGCLQTCHCENGGLCDPYAGCLCVGNWTGPTCEIKTCP ***.:*: * *:*** *.:*..* * * * ** : **:* .* * ** . TIE2_Hsap RMT--------------------------------------------------------- TIE1_Hsap --I--------------------------------------------------------- TIE1_Mmus --I--------------------------------------------------------- TIE2_Mmus RMT--------------------------------------------------------- Tie_Spur DGTIYGSLCADSGECQNGGTCDPCLGCLCTEDLAGPTCQEKAFYFNTSHDVAMVDETRVQ TIE2_Hsap ------------------------------------------------------------ TIE1_Hsap ------------------------------------------------------------ TIE1_Mmus ------------------------------------------------------------ TIE2_Mmus ------------------------------------------------------------ Tie_Spur LICGCTSAVPANQCPAFEIERFNPSNMIGMGEDYSFPTSTSLGLSFTPVGSIGNWNFRCR TIE2_Hsap ---------------------PKIVDLPDHIEVNSGKFNPI-CKASGWPLPTNEEMTLVK TIE1_Hsap ---------------------PQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRK TIE1_Mmus ---------------------PQILSMATEVEFNIGTMPRINCAAAGNPFPVRGSMKLRK TIE2_Mmus ---------------------PQIEDLPDHIEVNSGKFNPI-CKASGWPLPTSEEMTLVK Tie_Spur PVDFRGQDTSLTLKVNVTGDPPRIMEFWLAEVVNLDQRAKFHCRVEGLSYQ-DVNVTLVT *:* .: .* : * . * . .: * . TIE2_Hsap PDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKP TIE1_Hsap PDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVP TIE1_Mmus PDGTMLLSTKVIVEPDRTTAEFEVPSLTLGDSGFWECRVSTSGGQDSRRFKVNVKVPPVP TIE2_Mmus PDGTVLQPNDFNYTDRFSVAIFTVNRVLPPDSGVWVCSVNTVAGMVEKPFNISVKVLPEP Tie_Spur PSSHVIESGELVGPTSSPTFLFSIPGVTKGDEGTYHCIADGITGSDQQECSLEVFVQPVP *.. :: . . .. * : : *.* : * .. * .: .:.* * * * TIE2_Hsap LNAPNVIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVT-NE--IVTL TIE1_Hsap LAAPRLLTKQSRQLVVS-PLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSE--NVTL TIE1_Mmus LTAPRLLAKQSRQLVVS-PLVSFSGDGPISSVRLHYRPQDSTIAWSAIVVDPSE--NVTL TIE2_Mmus LHAPNVIDTGHNFAIINISSEPYFGDGPIKSKKLFYKPVN--QAWKYIEVT-NE--IFTL Tie_Spur VNSPIIVDTNSRAVEINLNIDEYTGDGPIQGVELQYKRVGG-DAWTPMTVSINEASAAVV : :* :: . . :. : *****. .* *: . * : * .* .: TIE2_Hsap NYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTASI-GLPPPRGL-NLLPKSQTTLNLT TIE1_Hsap MNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLE-GWHVEGTDRLRVS TIE1_Mmus MNLKPKTGYNVRVQLSRPGEGGEGGWGPSALMTTDCPEPLLQPWLE-SWHVEGPDRLRVS TIE2_Mmus NYLEPRTDYELCVQLARPGEGGEGHPGPVRRFTTASI-GLPPPRGL-SLLPKSQTALNLT Tie_Spur PNLVHNQDYEVRVVLWRRGSGGRGTYGPTTSLTTTCSRPTAEFWLRLTTPIEEWSSIELN * . *.: * * * *.**.* ** :** . : :.:. TIE2_Hsap WQ-PIFP--SSEDDFYVEVERRSVQ-KSDQQNIKVPGNLTS------------------- TIE1_Hsap WSLPLVPGPLVGDGFLLRLWDGTRG-QERRENVSSPQART-------------------- TIE1_Mmus WSLPSVP--LSGDGFLLRLWDGARG-QERRENISFPQART-------------------- TIE2_Mmus WQ-PIFT--NSEDEFYVEVERRSLQTTSDQQNIKVPGNLTS------------------- Tie_Spur WSQIRD-TGDELSGFRIEY-QKSGG-SVRTVEIPDSGTRTHKLTGLLANTHYTVILIPFN *. . * :. : :: . * TIE2_Hsap ------------------------------------------------------------ TIE1_Hsap ------------------------------------------------------------ TIE1_Mmus ------------------------------------------------------------ TIE2_Mmus ------------------------------------------------------------ Tie_Spur CGGDSVSTLSSATTRQGPPGPVGNFQLTVTSSDTITASWRIPEETRGDIVHYSIKVFEKV TIE2_Hsap ------------------------------------------------------------ TIE1_Hsap ------------------------------------------------------------ TIE1_Mmus ------------------------------------------------------------ TIE2_Mmus ------------------------------------------------------------ Tie_Spur DGVVSDTAHWDDTTQNTVSQIFNLKPYTSYVVEVYARTVLVGEISRKEVTTKETAPSGPP TIE2_Hsap ---------------------------------------------------------VLL TIE1_Hsap ---------------------------------------------------------ALL TIE1_Mmus ---------------------------------------------------------ALL TIE2_Mmus ---------------------------------------------------------VLL Tie_Spur STPSVIGQTMDTRMSFAWRPPPVDQRNGVIIVYEWNVMYVTTDGVYQSDVENVTETLATL . * TIE2_Hsap NNLHPREQYVVRARVNT-KAQGEWSEDLTAWTLSD------------------------- TIE1_Hsap TGLTPGTHYQLDVQLYHCTLLGPASPPA-HVLLPP------------------------- TIE1_Mmus TGLTPGTHYQLDVRLYHCTLLGPASPPA-HVHLPP------------------------- TIE2_Mmus SNLVPREQYTVRARVNT-KAQGEWSEELRAWTLSD------------------------- Tie_Spur TNLIPNRRYTFKVRAFTLEGPGPFTPSISHKTLTTEEAAKYLTTPPIAITVRGNPDLPNE ..* * :* . .: * : *. TIE2_Hsap ------------------------------------------------------------ TIE1_Hsap ------------------------------------------------------------ TIE1_Mmus ------------------------------------------------------------ TIE2_Mmus ------------------------------------------------------------ Tie_Spur TGGRTGPSISENKASGGISSNTVLALGLVCVSIIIIVAIVFGGWMYKKRKTAGSVEFVAS TIE2_Hsap ------------------------------------------------------------ TIE1_Hsap ------------------------------------------------------------ TIE1_Mmus ------------------------------------------------------------ TIE2_Mmus ------------------------------------------------------------ Tie_Spur IAGSEIGTYRFNEMQMRDIVDELSGFRIEYRKTGGSTMTVEIPDAGTRTHKLTGLLANTH TIE2_Hsap ------------------------ILPPQPE-NIKISNITHSSAVISWTILDGY--SISS TIE1_Hsap ------------------------SGPPAPR-HLHAQALSDSEIQLTWKHPEALPGPISK TIE1_Mmus ------------------------SGPPAPR-HLHAQALSDSEIQLMWQHPEAPSGPISK TIE2_Mmus ------------------------ILPPQPE-NIKISNITDSTAMVSWTIVDGY--SISS Tie_Spur YTVIMTPFSCGGDSVSVQSSAETRQGPPGPVGNLQLIVKSSDRITANWRIPEETRGVIQS ** * ::: : . * : *.. TIE2_Hsap ITIR--YKVQGKNED-QHVDVKIKNATITQYQLKGLEPETAYQVDIFAE----------- TIE1_Hsap YVVE--VQVAGGAGDPLWIDVDRPE--ETSTIIRGLNASTRYLFRMRAS----------- TIE1_Mmus YIVE--IQVAGGSGDPQWMDVDRPE--ETSIIVRGLNASTRYLFRVRAS----------- TIE2_Mmus IIIR--YKVQGKNED-QHIDVKIKNATVTQYQLKGLEPETTYHVDIFAE----------- Tie_Spur YFIRVFEKVDGVVSDTALLD-RRSD--NTVFQIFDLKPYTSYVVEVYATTKHPSEGEISR :. :* * * :* : * : .*:. * * . : * TIE2_Hsap ------------------------------------------------------------ TIE1_Hsap ------------------------------------------------------------ TIE1_Mmus ------------------------------------------------------------ TIE2_Mmus ------------------------------------------------------------ Tie_Spur KEVTTKETAPSGPPSTPSVIGQTMDTRMSFAWHPPPVDQRNGVIIVYEWNVMYVTTDGVY TIE2_Hsap --------------------------------NNIGSSNPAFSHELVTLP---------- TIE1_Hsap -------------------------------IQGLGDW--SNTVEESTLGNGLQA----- TIE1_Mmus -------------------------------VQGLGDW--SNTVEEATLGNGLQS----- TIE2_Mmus --------------------------------NNIGSSNPAFSHELRTLP---------- Tie_Spur QSDVENVTETLATLTNLIPNRRYTFKVRAFTLEGPGPFTPSISHN--TLTTEEAAKYLTT :. * : : : ** TIE2_Hsap ------------------------ESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLII TIE1_Hsap --------------------EGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTL TIE1_Mmus --------------------EGPVRESRAAEEGLDQQLVLAVVGSVSATCLTILAALLAL TIE2_Mmus ------------------------HSPGSADLGGGKMLLIAILGSAGMTCITVLLAFLIM Tie_Spur PPIAITARGNPDLPNETGGRTGPSISENKASGGISSNTVLA----LGLVCVSIIIIVAIV . *. * .. ::* . .*:::: . : TIE2_Hsap LQ---L-KR------------------------ANVQRRMAQAFQN-VREEPAVQFNSGT TIE1_Hsap VC---I-RR------------------------SCLHRRRTFTYQSGSGEETILQFSSGT TIE1_Mmus VC---I-RR------------------------SCLHRRRTFTYQSGSGEETILQFSSGT TIE2_Mmus LQ---L-KR------------------------ANVQRRMAQAFQN-VREEPAVQFNSGT Tie_Spur FGGWMYKKRKTAGSVEFVASIAGSEIGTYRFNEMLARQQSAQSATN-DYDENSRGLMLGA . :* ::: : : . :* : *: TIE2_Hsap LALNRKVKNNPDPTIYPVLDWNDIKFQD-VIGEGNFGQVLKARIKKDGLRMDAAIKRMKE TIE1_Hsap LTLTRRPKLQPEPLSYPVLEWEDITFED-LIGEGNFGQVIRAMIKKDGLKMNAAIKMLKE TIE1_Mmus LTLTRRPKPQPEPLSYPVLEWEDITFED-LIGEGNFGQVIRAMIKKDGLKMNAAIKMLKE TIE2_Mmus LALNRKAKNNPDPTIYPVLDWNDIKFQD-VIGEGNFGQVLKARIKKDGLRMDAAIKRMKE Tie_Spur MA--SPPGSPLPPIDYWRIPLDCLTLENFVIAEGNFGQVMKATVKKDGGVIEVAVKTLKD :: * * : : :.::: :*.*******::* :**** ::.*:* :*: TIE2_Hsap YASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRV TIE1_Hsap YASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRV TIE1_Mmus YASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRV TIE2_Mmus YASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRV Tie_Spur GTSEADRKDFMGELEIMCKVGTHPNIVNLVGACEHQGILYVATEYARYGNLLNFLRSSRT :*: *::** ****::**:* ****:**:***:::* **:* *** :****:***.**. TIE2_Hsap LETDPAFAIAN------STASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVG TIE1_Hsap LETDPAFAREH------GTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVG TIE1_Mmus LETDPAFAREH------GTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVG TIE2_Mmus LETDPAFAIAN------STASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVG Tie_Spur IEADSPFPSSPTSRFKVNVSTSLTAEQILGFAADVALGMQHLAQKGCVHRDLAARNILVC :*:*..*. ..:::*::.*:* **:*.* **::*::* :********:** TIE2_Hsap ENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVS TIE1_Hsap ENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVS TIE1_Mmus ENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVS TIE2_Mmus ENYIAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVS Tie_Spur DNYVCKVTDFGLSRSDEVYVKTTAGRLPVRWMAIESLNYSVYTTKSDV------------ :* .*::******.:*****.* ********************:*** TIE2_Hsap LGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLN TIE1_Hsap LGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLG TIE1_Mmus LGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLG TIE2_Mmus LGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLN Tie_Spur ------------------------------------------------------------ TIE2_Hsap RMLEERKTYVNTTLYEKFTYAGIDCSAEEAA TIE1_Hsap RMLEARKAYVNMSLFENFTYAGIDATAEE-A TIE1_Mmus RMLEARKAYVNMSLFENFTYAGIDATAEE-A TIE2_Mmus RMLEERKTYVNTTLYEKFTYAGIDCSAEEAA Tie_Spur -------------------------------