CLUSTAL W (1.83) multiple sequence alignment KDR_Hsap MQSK-------------------------------------------------------- FLT4_Hsap MQRG-------------------------------------------------------- FLT1_Hsap MVSYWDT----------------------------------------------------- CG3277_Dmel MHHS-------------------------------------------------------- Pvr_Dmel MAML-------------------------------------------------------- KDR_Mmus MESK-------------------------------------------------------- FLT4_Mmus MQPG-------------------------------------------------------- FLT1_Mmus MVSCWDT----------------------------------------------------- VEGFR2_Spur MEKQVSSICRSANFHLRNVRRIRKYMSK-------------------------------Q VEGFR1_Spur MAFAESPEG-LATFQR-----------TTTRSNEEPPDEGGGFPARGSGKTKPQRGRGNP * KDR_Hsap ------------------------------VLLAVALWLCVE---TRAASVGLP------ FLT4_Hsap ------------------------------AALCLRLWLCLGL--LDGLVS--------- FLT1_Hsap ------------------------------GVLLCALLSCLL---LTGSSS--------- CG3277_Dmel ------------------------------TKVPSRIVLILLLVLVRNAVGQAPRENA-- Pvr_Dmel ------------------------------PR---LILLPLLLILRISWSDAVPLQQFSP KDR_Mmus ------------------------------ALLAVALWFCVE---TRAASVGLP------ FLT4_Mmus ------------------------------AALNLRLWLCLGL--LQGLAN--------- FLT1_Mmus ------------------------------AVLPYALLGCLL---LTGYGS--------- VEGFR2_Spur TTEQ-----------------------IIHALVTSRLDCCNAL------LVGVP------ VEGFR1_Spur DPAANSLLGELARVVGDGSIATITGQKARGERLATAQSLSLVE---LG-KTGLP------ KDR_Hsap ---------SVSL----------------------------------------------- FLT4_Hsap ---------GYSM----------------------------------------------- FLT1_Hsap ---------GSKL----------------------------------------------- CG3277_Dmel ------------------------------------------------------------ Pvr_Dmel DPDDSIENCGGEN----------------------------------------------- KDR_Mmus ---------GDFL----------------------------------------------- FLT4_Mmus ---------GYSM----------------------------------------------- FLT1_Mmus ---------GSKL----------------------------------------------- VEGFR2_Spur ---------SSAISRLQRVHNNAARVLTKAGKYARISHILRQLHWLPHNFYYSSILTVPV VEGFR1_Spur ---------LNKV----------------------------------------------- KDR_Hsap ---------------------------------------------------DLPRL---- FLT4_Hsap ---------------------------------------------------TPPTL---- FLT1_Hsap ---------------------------------------------------KDPEL---- CG3277_Dmel ---------------------------------------------------TNPTL---- Pvr_Dmel ---------------------------------------------------GAPLM---- KDR_Mmus ---------------------------------------------------HPPKL---- FLT4_Mmus ---------------------------------------------------TPPTL---- FLT1_Mmus ---------------------------------------------------KVPEL---- VEGFR2_Spur TCQNILVTVHPDTVQVTEGLSATLHCNYTVPIIDSSLDQLDQDLEPVQVSNQDPTITWLK VEGFR1_Spur ---------------------------------------------------GPPRL---- * : KDR_Hsap ------------------------------------------------------------ FLT4_Hsap ------------------------------------------------------------ FLT1_Hsap ------------------------------------------------------------ CG3277_Dmel ------------------------------------------------------------ Pvr_Dmel ------------------------------------------------------------ KDR_Mmus ------------------------------------------------------------ FLT4_Mmus ------------------------------------------------------------ FLT1_Mmus ------------------------------------------------------------ VEGFR2_Spur DGAVLRTYSGVGRNTVTQSDRIAIVAPTSLMISRAVDEDAGTYTCQIEQGALIGSASATL VEGFR1_Spur ------------------------------------------------------------ KDR_Hsap ----------SIQKD-ILTIKANTTLQITCRGQRDLDWLWPNNQSGS------EQRVEVT FLT4_Hsap ----------NITEE-SHVIDTGDSLSISCRGQHPLEWAWPGAQEAPATGDKDSEDTGVV FLT1_Hsap ----------SLKGT-QHIMQAGQTLHLQCRGEAAHKWSLPEMVSKE------SERLSIT CG3277_Dmel ------------------I-------------------------S--------------- Pvr_Dmel ----------TPCKS-AIILDAQTSTTLKCEDDEPMSWWTSQSQYVH------VKSFDNT KDR_Mmus ----------STQKD-ILTILANTTLQITCRGQRDLDWLWPNAQRDS------EERVLVT FLT4_Mmus ----------NITED-SYVIDTGDSLSISCRGQHPLEWTWPGAQEVLTTGGKDSEDTRVV FLT1_Mmus ----------SLKGT-QHVMQAGQTLFLKCRGEAAHSWSLPTTVSQE------DKRLSIT VEGFR2_Spur NVVGSTPDLLGHEGSYETSILEGETLRLQCKGSYPLSWTYYQGIDHS------KVFIRST VEGFR1_Spur ----------ETESS-TLLISQNNTLQLSCHGGFRLDWIYPYEIERT------RISIEQE KDR_Hsap E---C--SDGLFCKTLTIPKVIGNDTGAYKCFYRET--------------------DLAS FLT4_Hsap -RDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKAR--------------IEGTTAA FLT1_Hsap K-SACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTS--------------KKKETES CG3277_Dmel ----------------------------------LVRSSEKEPE--------------QM Pvr_Dmel E-----DPARPFGTSLHLIEVTADYVAAYYCVKTSKFSQIAKEEQSDEAMIELVNQGYAS KDR_Mmus E---CGGGDSIFCKTLTIPRVVGNDTGAYKCSYRDV--------------------DIAS FLT4_Mmus -HDCEGTEARPYCKVLLLAQTHANNTGSYHCYYKYIKAR--------------IEGTTAA FLT1_Mmus PPSACGRDNRQFCSTLTLDTAQANHTGLYTCRYLPTSTS--------------KKKKAES VEGFR2_Spur LTPILDSSSWNETSELLVVNATTTDTGYFTCTHTHD------------------SEDFSR VEGFR1_Spur HC--SACSPKRHRSVLTIASADVGDTGKYQCLYKKYDTK--------------INNETSA KDR_Hsap VIYVYVQ--DYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRF FLT4_Hsap SSYVFVR--DFEQPFINKP----DTLLV--NRKDAMWVPCLVSIPGLNVTLRSQ--SSVL FLT1_Hsap AIYIFIS--DTGRPFVEMYSEIPEIIHM--TEGRELVIPCRVTSPNITVTLKK-FPLDTL CG3277_Dmel ESHRYVT--GLSEPIAMEP----LTRM-----------------------------RLNP Pvr_Dmel SIYVYVN--DPDTKLVDSH----NVVTA--RQYTDVVIPCKPAMPDTEVLLETS--NGEM KDR_Mmus TVYVYVR--DYRSPFIASVSDQHGIVYITENKNKTVVIPCRGSISNLNVSLCARYPEKRF FLT4_Mmus STYVFVR--DFKHPFINKP----DTLLV--NRKDSMWVPCLVSIPGLNITLRSQ--SSAL FLT1_Mmus SIYIFVS--DAGSPFIEMHTDIPKLVHM--TEGRQLIIPCRVTSPNVTVTLKK-FPFDTL VEGFR2_Spur DIYVYVNASDANRLFLPSDTTT---ISV--YALDPFILPCRVTVPSTEVNLV--LPNGGV VEGFR1_Spur KVYVYIS--SPEHLFVPPEWTQ---NNI--YRGQPFVLPCRTTSPNLNVTLVQ-RGTGRD : :: . : KDR_Hsap VPDGNRISWDSKKGFTIPSYMI-SYAGMVFCEAKI----NDESYQSIMYIVVVVGYRIYD FLT4_Hsap WPDGQEVVWDDRRGMLVSTPLL-HDALYLQCETTW----GDQDFLSNPFLVHITGNELYD FLT1_Hsap IPDGKRIIWDSRKGFIISNATY-KEIGLLTCEATV----NGHLYKTN-YLTHRQTNTIID CG3277_Dmel NPDGEIT----------------------------------------------------- Pvr_Dmel HSSKSVGRYDPQRGFTIEIRSI-VDGGDYYCRPNPPFPHNEEEMTSIEVRFIGNGHIDKD KDR_Mmus VPDGNRISWDSEIGFTLPSYMI-SYAGMVFCEAKI----NDETYQSIMYIVVVVGYRIYD FLT4_Mmus HPDGQEVLWDDRRGMRVPTQLL-RDALYLQCETTW----GDQNFLSNLFVVHITGNELYD FLT1_Mmus TPDGQRITWDSRRGFIIANATY-KEIGLLNCEATV----NGHLYQTN-YLTHRQTNTILD VEGFR2_Spur VSRDELPSYDNKIGFSVSGVEADLYQGDVSCRATY----EGSTVEQTYFVQIIRKPTI-- VEGFR1_Spur ITDHRYHRYDPKKGFHISANHH-ELDGHVCCKAQN----GEHIDRSCFNLNFQEQAPVLE . KDR_Hsap VV------LSPSHGIELSVGEKLVLNCTARTELNVGI-DFNWEYPSSKHQHKKLVNRDLK FLT4_Hsap IQ------LLPRKSLELLVGEKLVLNCTVWAEFNSGV-TFDWDYPGKQAERGKWVPERRS FLT1_Hsap VQ------ISTPRPVKLLRGHTLVLNCTATTPLNTRV-QMTWSYPDEKNKRASV-RRRI- CG3277_Dmel ---------------------ELTTNVTLYMEKIPRL-QVRWQD---------------- Pvr_Dmel GKPLPKPVIRSSVEHHVFTDTNFTLDCEQSAYVESVY-GMEWFTPSRDENRIFASQSRTD KDR_Mmus VI------LSPPHEIELSAGEKLVLNCTARTELNVGL-DFTWHSPPSKSHHKKIVNRDVK FLT4_Mmus IQ------LYPKKSMELLVGEKLVLNCTVWAEFDSGV-TFDWDYPGKQAERAKWVPERRS FLT1_Mmus VQ------IRPPSPVRLLHGQTLVLNCTATTELNTRV-QMSWNYPGKATKRASI-RQRI- VEGFR2_Spur --------LNSTADIKIKEFTKLTLVCEGAQPL--------------------------- VEGFR1_Spur PR------VSISTTEVLEGWEGFSVSCEVSAPADSLLDDLSWDYPAEMIAERQDSNYKIV : KDR_Hsap TQ--------SGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGL----M------------ FLT4_Hsap QQ-----------THTELSSILTIHNVSQHDLGSYVCKANNGI----Q------------ FLT1_Hsap DQ--------SNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGP----S------------ CG3277_Dmel --------------------------------------------NLPQ------------ Pvr_Dmel PKT-------RNSTHQTGRSTLTVLNAQPSDTGLYKCVTTDNSNQNVQ------------ KDR_Mmus PF--------PGTVAKMFLSTLTIESVTKSDQGEYTCVASSGR----M------------ FLT4_Mmus QQ-----------THTELSSILTIHNVSQNDLGPYVCEANNGI----Q------------ FLT1_Mmus DR--------SHSHNNVFHSVLKINNVESRDKGLYTCRVKSGS----S------------ VEGFR2_Spur ------------------------------------------------------------ VEGFR1_Spur TDGSTESVRGSSLAMQKYVSTLNVVRAHSYDNGTYVCIATNFW----DSYFAEASINVIG KDR_Hsap ----------TKK-NSTFVRVHEKPFVAFGSGMESLVEAT-------------------- FLT4_Hsap ----------RFR-ESTEVIVHENPFISVEWLKGPILEAT-------------------- FLT1_Hsap ----------FKS-VNTSVHIYDKAFITVKHRKQQVLETV-------------------- CG3277_Dmel ----------GTS-YNVLVSAVNNSRC--------------------------------- Pvr_Dmel ----------RAT-YRIKVLKQNESYLNVGEPSGHYNVQE-------------------- KDR_Mmus ----------IKR-NRTFVRVHTKPFIAFGSGMKSLVEAT-------------------- FLT4_Mmus ----------RFR-ESTEVIVHEKPFISVEWLKGPVLEAT-------------------- FLT1_Mmus ----------FQS-FNTSVHVYEKGFISVKHRKQPVQETT-------------------- VEGFR2_Spur -------------------------------------IWVHELPDL-EVNIIVSTLR--R VEGFR1_Spur VTHLKRIGPPRIRSNTTERFLRENSTLEIRCTGGVALEWIY--PEAVRSRVSLGSQACPT KDR_Hsap ------------------------------------------------------------ FLT4_Hsap ------------------------------------------------------------ FLT1_Hsap ------------------------------------------------------------ CG3277_Dmel ------------------------------------------------------------ Pvr_Dmel ------------------------------------------------------------ KDR_Mmus ------------------------------------------------------------ FLT4_Mmus ------------------------------------------------------------ FLT1_Mmus ------------------------------------------------------------ VEGFR2_Spur PNGDVYYRSILDIDPAQYSNTGYFSCLFLRYIKSEDLSLRTSVYVFVSSDDETRI----- VEGFR1_Spur CDSNAHFTSTLTVRSARPQDSGQFQCIYSRYVDHINNATAAEINIFVAADNAQLHSKGPP KDR_Hsap ---------VGER-VRIPAKYLGYPPPEIKWYK-NGIPLE--S----NHT----IKAGHV FLT4_Hsap ---------AGDELVKLPVKLAAYPPPEFQWYK-DGKALS--G----RHS-------PHA FLT1_Hsap ---------AGKRSYRLSMKVKAFPSPEVVWLK-DGLPATEKS----ARY----LTRGYS CG3277_Dmel ---------------------------------------------------------PD- Pvr_Dmel ---------YANRTIQMTANFEGFPTPSFSWFKPDGTEVRQSE----NNFKILSTELSTM KDR_Mmus ---------VGSQ-VRIPVKYLSYPAPDIKWYR-NGRPIE--S----NYT----MIVGDE FLT4_Mmus ---------AGDELVKLPVKLAAYPPPEFQWYK-DRKAVT--G----RHN-------PHA FLT1_Mmus ---------AGRRSYRLSMKVKAFPSPEIVWLK-DGSPATLKS----ARY----LVHGYS VEGFR2_Spur -----------------------------FLPK-YATEHIEYNKSNPVT----------- VEGFR1_Spur IIYVNNSHIIQNEYQNLELRCTGSSTIDWSWPQ-DATERVEQRSIECPTC-PVALQSTST KDR_Hsap LTIMEVSERDTGNYTVILTNPISKEKQSHVVSL--------------------------- FLT4_Hsap LVLKEVTEASTGTYTLALWNSAAGLRRNISLEL--------------------------- FLT1_Hsap LIIKDVTEEDAGNYTILLSIKQSNVFKNLTATL--------------------------- CG3277_Dmel ------------------------------------------------------------ Pvr_Dmel LQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSV--------------------------- KDR_Mmus LTIMEVTERDAGNYTVILTNPISMEKQSHMVSL--------------------------- FLT4_Mmus LVLKEVTEASAGVYTLALWNSAAGLRQNISLEL--------------------------- FLT1_Mmus LIIKDVTTEDAGDYTILLGIKQSRLFKNLTATL--------------------------- VEGFR2_Spur ------------------------------------------------------------ VEGFR1_Spur LKVSNASYKDTGFYRCFYSRFSDRLTPETSAEVYAYITSDVDAMKLFTINGWYYWAKIIT KDR_Hsap -------------------------------VV----YVPPQIGEK-------------- FLT4_Hsap -------------------------------VV----NVPPQIHEK-------------- FLT1_Hsap -------------------------------IV----NVKPQIYEK-------------- CG3277_Dmel ------------------------------------------------------------ Pvr_Dmel -------------------------------M-----DAP-------------------- KDR_Mmus -------------------------------VV----NVPPQIGEK-------------- FLT4_Mmus -------------------------------VV----NVPPHIHEK-------------- FLT1_Mmus -------------------------------IV----NVKPQIYEK-------------- VEGFR2_Spur -----VPCRISDPSRLVTFKVFYKDTYKEYLTFYWTYTYDPKVGYLLEPERIDVEAISLI VEGFR1_Spur GSSYTIPCTVTDPRINVTLEYGNEILSEEGSVI----TYDPRVGFKVPGDYK-HTQYNDN KDR_Hsap ------------------------------------------SLISPV--DSYQYGTTQT FLT4_Hsap ------------------------------------------EASS---PSIYSRHSRQA FLT1_Hsap ------------------------------------------AVSSFPDPALYPLGSRQI CG3277_Dmel ------------------------------------------------------------ Pvr_Dmel -------------------------------------------ALKMS-DAYVQVGSVAR KDR_Mmus ------------------------------------------ALISPM--DSYQYGTMQT FLT4_Mmus ------------------------------------------EASS---PSIYSRHSRQT FLT1_Mmus ------------------------------------------SVSSLPSPPLYPLGSRQV VEGFR2_Spur FTCYAITANRTSNQTLPDNDRNLASMTMILDAGANEKPLLKLQVTQ-DKQEVIAYKEGFQ VEGFR1_Spur LICKARKG-------------NLTQIKKILLNFEPKAPVPAPQIQG---PIEQVKGYTFN KDR_Hsap LTC--TVY-------AIPPPHHIHWYWQLEE-ECANEP--SQA----------------- FLT4_Hsap LTC--TAY-------GVPLPLSIQWHWRPWT-PCKMFA--QRS----------------- FLT1_Hsap LTC--TAY-------GIPQP-TIKWFWHP----CNHNH--SEA----------------- CG3277_Dmel APC--SEY-------GIKEK-NASAETHSVNLPVNPNLNVESVDCNYMFGCQYQVIVETS Pvr_Dmel LEC--TVR-------SYPPA-IVTFFFRP----CSLEP--QWPTCSV----------LNQ KDR_Mmus LTC--TVY-------ANPPLHHIQWYWQLEE-ACSYRP--GQT----------------- FLT4_Mmus LTC--TAY-------GVPQPLSVQWHWRPWT-PCKTFA--QRS----------------- FLT1_Mmus LTC--TVY-------GIPRP-TITWLWHP----CHHNH--SKE----------------- VEGFR2_Spur LNCIGTVAAYLLSLEN-SVEYQPSFAWVR---PGGQRP--TELERK------------YD VEGFR1_Spur VTC--NVE-------S-PLGIQIRWKWDY---PGLHNP--NANPNNY----------RTE * . KDR_Hsap --VSV------TNPYPCEEWR----SVEDFQGGNKIEV---------------------- FLT4_Hsap --LRRRQQQ--DLMPQCRDWR----AVTTQDAVNPIES---------------------- FLT1_Hsap --R----------CDFCSNNEESFILDADSNMGNRIES---------------------- CG3277_Dmel NAMVRRSAR--VYIPQCLEGK----C-SCQLAPTPP------------------------ Pvr_Dmel NFSLPSEQE--KYQFQTRPRP----GKLSVERIYEV------------------------ KDR_Mmus ------------SPYACKEWR----HVEDFQGGNKIEV---------------------- FLT4_Mmus --LRRRQQR--DGMPQCRDWK----EVTTQDAVNPIES---------------------- FLT1_Mmus --R----------YDFCTENEESFILDPSSNLGNRIES---------------------- VEGFR2_Spur EFG-------FDTTTYDAQFI----KFMIVENATLEEDGTYTCYAENIGLALEEEITVQV VEGFR1_Spur KSSRELQAEVGDSTRAFRRFK----GTLTVFQASPIDNGTYTCTVINNNGNGSTTHAVSI KDR_Hsap ------------------------------------------------------NKNQFA FLT4_Hsap ------------------------------------------------------LDTWTE FLT1_Hsap ------------------------------------------------------ITQRMA CG3277_Dmel ------------------------------------------------------------ Pvr_Dmel ------------------------------------------------------------ KDR_Mmus ------------------------------------------------------TKNQYA FLT4_Mmus ------------------------------------------------------LDSWTE FLT1_Mmus ------------------------------------------------------ISQRMT VEGFR2_Spur HARGYAGISHRYNATDPSTNLTAIVNHPKCISFDVPAYPPPQVKLSPQRNWVLTM----- VEGFR1_Spur LDQGYIHMEPLKGELMQLVSGEEHAKDRDRIMVHLKYFPNADFTWFKDGIEVDALDQYLF KDR_Hsap LIEGKNK-TVSTLVIQAANVSALYKCEAVNKVGRGERV-I-S--FHVTRGPE-ITL---Q FLT4_Hsap FVEGKNK-TVSKLVIQNANVSAMYKCVVSNKVGQDERL-I-Y--FYVTTIPDGFTIE-SK FLT1_Hsap IIEGKNK-MASTLVVADSRISGIYICIASNKVGTVGRN-I-S--FYITDVPNGFHV---N CG3277_Dmel --------------KVLA--------VAK-------------ML-SNETISINLSILA-- Pvr_Dmel --------------SFLPTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFD KDR_Mmus LIEGKNK-TVSTLVIQAANVSALYKCEAINKAGRGERV-I-S--FHVIRGPE-ITV---Q FLT4_Mmus FVEGKNK-TVSKLVIQDANVSAMYKCVVVNKVGQDERL-I-Y--FYVTTIPDGFSIE-SE FLT1_Mmus VIEGTNK-TVSTLVVADSQTPGIYSCRAFNKIGTVERN-I-K--FYVTDVPNGFHV---S VEGFR2_Spur --DSSTKILSMCSPNVSEAHEGDYTVYVWNEYENATIS-F-F--FSVQDTAAGVSIS-TG VEGFR1_Spur KSRIKQDVAQVKLLNINAQHAGNYTLIGDNGDVQESVT-I-R--VVVHDVEEGLTIE-GQ . : KDR_Hsap PDMQPT-EQESVSLWCTADRSTFE-NLTWYKLGPQP-LPIHVGELPTPVCKNLDTL---W FLT4_Hsap PSEELL-EGQPVLLSCQADSYKYE-HLRWYRLNLST-LHDAHGNPLLLDCKNVHLFATPL FLT1_Hsap LEKMPT-EGEDLKLSCTVNKFLYR-DVTWILLRTVNNRTMHYSIS--------------- CG3277_Dmel ---------S-ELLRKEQDSHLHE-TLRTYKMQLN-EL---------------------- Pvr_Dmel KDHKIA-KEDNVNFTCEALAYHFDGNLKWFINGED-LK---ESDS--------------- KDR_Mmus PAAQPT-EQESVSLLCTADRNTFE-NLTWYKLGSQA-TSVHMGESLTPVCKNLDAL---W FLT4_Mmus PSEDPL-EGQSVRLSCRADNYTYE-HLRWYRLNLST-LHDAQGNPLLLDCKNVHLFATPL FLT1_Mmus LEKMPA-EGEDLKLSCVVNKFLYR-DITWILLRTVNNRTMHHSIS--------------- VEGFR2_Spur S-DIAY-ISDDLTLECHATVFFFT-EIKWVFISPNG-TDV-------------WLNSSAP VEGFR1_Spur EETTIVEEKGNLTLHCKSSSHIFD-NIKWLVVRSHG-STN-ESR---------LLRPREE : . : KDR_Hsap KLNATMFSNSTN-------------DILIMELKNASLQDQGDYVCLAQDRK-TKKRHCVV FLT4_Hsap AASLEEVAPGARH------------ATLSLSIPRVAPEHEGHYVCEVQDRR-SHDKHCHK FLT1_Hsap KQ--KMAITKEHS------------ITLNLTIMNVSLQDSGTYACRARNVY-TGEEILQK CG3277_Dmel --NFR-ATPKGFEGVMKLGLGTQLKEKASLSLQAVIIDPTG------------------- Pvr_Dmel -VHIE-TSHTKYS------------YKSTVHITTISDRDRGTYECRAYHNDKDAAYSSRE KDR_Mmus KLNGTMFSNSTN-------------DILIVAFQNASLQDQGDYVCSAQDKK-TKKRHCLV FLT4_Mmus EANLEEAEPGARH------------ATLSLNIPRVAPEDEGDYVCEVQDRR-SQDKHCHK FLT1_Mmus KQ--KMATTQDYS------------ITLNLVIKNVSLEDSGTYACRARNIY-TGEDILRK VEGFR2_Spur KYSFPL----Y-S------------LVSTLLVTNVSFSDAGSYVCVATNGS-NPNWEKNA VEGFR1_Spur RVTITSYSDGD-F------------NVTQLHIQDMGRSDDGIYICLAHSVLDSRDTKEVE : . * KDR_Hsap RQLTVLERVAPTITGNLEN----QTTSIG-ESIEVSCT-ASGNPPPQIMWFKDNETLVE- FLT4_Hsap KYLSVQALEAPRLTQNLTD----LLVNVS-DSLEMQCL-VAGAHAPSIVWYKDERLLEE- FLT1_Hsap KEITIRDQEAPYLLRNLSD----HTVAIS-SSTTLDCH-ANGVPEPQITWFKNNHKIQQ- CG3277_Dmel -------CEGPRSVT----KVPEQLHNC-------------------------------- Pvr_Dmel IDLYVHDPSAPQWTNGGQEGHSKIKRKLS-QTLELECA-STAVPVAIVRWFKDDKEVTE- KDR_Mmus KQLIILERMAPMITGNLEN----QTTTIG-ETIEVTCP-ASGNPTPHITWFKDNETLVE- FLT4_Mmus KYLSVQALEAPRLTQNLTD----LLVNVS-DSLEMRCP-VAGAHVPSIVWYKDERLLEK- FLT1_Mmus TEVLVRDSEAPHLLQNLSD----YEVSIS-GSTTLDCQ-ARGVPAPQITWFKNNHKIQQ- VEGFR2_Spur SQ-VISVRELPKLKIEIGD----SEVKAG-ENVTIRCFLVRGHPIPKVQLKKENVQVYL- VEGFR1_Spur AAVQVQAIRVPEMIMGLET----EEINKSLKDFTLECE-ASGFPTPKITWFKDGSKLEIK * KDR_Hsap DSGIVLKDGNR--NLTIRRVRKEDEGLYTCQACSVLGCAK-VEAFFIIEGAQ---EKTNL FLT4_Hsap KSGVDLADSNQ--KLSIQRVREEDAGRYLCSVCNAKGCVN-SSASVAVEGSE---DKGSM FLT1_Hsap EPGIILGPGSS--TLFIERVTEEDEGVYHCKATNQKGSVE-SSAYLTVQGTS---DKSNL CG3277_Dmel -----------------------DERHADCHYPSWPDYAASSSPKSQDNG---Q------ Pvr_Dmel SKLRHIIEKES--KLLITHLYPGDEGVYKCVVENRLDRIE-RSFTVVISD---L------ KDR_Mmus DSGIVLRDGNR--NLTIRRVRKEDGGLYTCQACNVLGCAR-AETLFIIEGAQ---EKTNL FLT4_Mmus ESGIDLADSNQ--RLSIQRVREEDAGRYLCSVCNAKGCVN-SSASVAVEGSE---DKGSM FLT1_Mmus EPGIILGPGNS--TLFIERVTEEDEGVYRCRATNQKGAVE-SAAYLTVQGTS---DKSNL VEGFR2_Spur WQGV----GN--ISYTLTA-DINAGGNYYCEALDANSTSE-YA-ELVIEQPP----PGIL VEGFR1_Spur DSTVVLPNDHAVSTLRRTRINMVDSGLYCCVASNAGGQVN-SSAVIIILEEPYMRVKEDV * . . KDR_Hsap EIIILVGTAVI------------------------------------------------- FLT4_Hsap EIVILVGTGVI------------------------------------------------- FLT1_Hsap ELITLTCTCVA------------------------------------------------- CG3277_Dmel ------------------------------------------------------------ Pvr_Dmel PGISMAWVWFG------------------------------------------------- KDR_Mmus EVIILVGTAVI------------------------------------------------- FLT4_Mmus EIVILIGTGVI------------------------------------------------- FLT1_Mmus ELITLTCTCVA------------------------------------------------- VEGFR2_Spur ERILPYLVSII------------------------------------------------- VEGFR1_Spur KLVAMGGTANITCHDGGNPKPTIVWYHQPKDQASEMRILPAQMYNSTEGVLVLHDVQKDQ KDR_Hsap -----------------------------------------AMFFWLL-----LVIILRT FLT4_Hsap -----------------------------------------AVFFWVL-----LLLIFCN FLT1_Hsap -----------------------------------------ATLFWLL-----LTLFIRK CG3277_Dmel ------------------------------------------------------------ Pvr_Dmel -----------------------------------------VILFLIL-----IGLCVFL KDR_Mmus -----------------------------------------AMFFWLL-----LVIVLRT FLT4_Mmus -----------------------------------------AVFFWVL-----LLLIFCN FLT1_Mmus -----------------------------------------ATLFWLL-----LTLFIRK VEGFR2_Spur -----------------------------------------CVIFLII-----LIYCMYK VEGFR1_Spur QGTYLCNATNRLGSSTRTVSIKLDMPRPILGPGDVKRNTALGVVFVLLLVVVALIIVIFK KDR_Hsap V----K--RANGGE--------LKTGYLSIVMDPD--------ELPLDEHCERLPYDASK FLT4_Hsap M----R--RPAHAD--------IKTGYLSIIMDPG--------EVPLEEQCEYLSYDASQ FLT1_Hsap M----K--RSS-SE--------IKTDYLSIIMDPD--------EVPLDEQCERLPYDASK CG3277_Dmel ----------------AAQAG-------A-DLHPD--------LRHLRHRKSQVLGLADI Pvr_Dmel AVRYQKEHKR-HLALKAAGLANFEEGAVG-HINPD---------LTLDEQAELLPYN-RE KDR_Mmus V----K--RANEGE--------LKTGYLSIVMDPD--------ELPLDERCERLPYDASK FLT4_Mmus M----K--RPAHAD--------IKTGYLSIIMDPG--------EVPLEEQCEYLSYDASQ FLT1_Mmus L----K--RSS-SE--------VKTDYLSIIMDPD--------EVPLDEQCERLPYDASK VEGFR2_Spur Y----R--RRP-KV--------RRASRLPPIEMPRFGSNRRSIYSVSDDPYENIAYN-QR VEGFR1_Spur I----KKLRPKYIA--------GGDDMLLPISFGQ--------YNDLLDICEHLPYD-SK . . : KDR_Hsap WEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSEL FLT4_Hsap WEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSEL FLT1_Hsap WEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTEL CG3277_Dmel FEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVKQLKPNPKADEVAEYLAEI Pvr_Dmel FEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSEL KDR_Mmus WEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSEL FLT4_Mmus WEFPRERLHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLKEGATASEHRALMSEL FLT1_Mmus WEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTEL VEGFR2_Spur WEFPRERLKLGGVIGKGAFGMVIKAVAVGIDGTENNITVAVKKLKSGATSLEKKALWAEL VEGFR1_Spur WEFPRERLKIGPVIGRGAFGRVMRSSAFGIDKVDTCTTVAVKMLKD-------------- :*..:. :::* :* **** * .. * .: **** :* KDR_Hsap KILIHIGHHLNVVNLLGACTKP--GGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGAR FLT4_Hsap KILIHIGNHLNVVNLLGACTKP--QGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPE FLT1_Hsap KILTHIGHHLNVVNLLGACTKQ--GGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALH CG3277_Dmel EMLKGVGTHHNVVSFLGCCTIK---PPYLMIMEYVNKGNLLSYLRTVRKEASKLRNRNAN Pvr_Dmel KIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTD KDR_Mmus KILIHIGHHLNVVNLLGACTKP--GGPLMVIVEFCKFGNLSTYLRGKRNEFVPYKSKGAR FLT4_Mmus KILIHIGNHLNVVNLLGACTKP--NGPLMVIVEFCKYGNLSNFLRVKRDTFNPYAEKSPE FLT1_Mmus KILTHIGHHLNVVNLLGACTKQ--GGPLMVIVEYCKYGNLSNYLKSKRDLFCLNKDAALH VEGFR2_Spur KMLGHIGKHLNVVNFLGACTQ---NGPVLAIVEFCCHGNLLDFLRSKRKYFSETPEGTGS VEGFR1_Spur ---------------------------LFVISEFCPFGNLSDYLKTKRKNYVAEPDLLAI : * *: **: :* *. KDR_Hsap F-RQG--KDYV------------G------------------A--IPVDLKRRLDSITSS FLT4_Hsap Q-RGR--FRAMV-----------E-----------------------LARLDRRRPG-SS FLT1_Hsap M-EPK--KEKME-----------P------------------G--LEQGKKPRLDSVTSS CG3277_Dmel Y-T------------------------------------------SCRPIMTRTNST-SS Pvr_Dmel HIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSD-ND KDR_Mmus F-RQG--KDYV------------G------------------E--LSVDLKRRLDSITSS FLT4_Mmus Q-RRR--FRAMV-----------E-----------------------GAKADRRRPG-SS FLT1_Mmus M-ELK--KESLE-----------P------------------G--LEQGQKPRLDSVSSS VEGFR2_Spur --------------------------------------------------QSHTG-H-SS VEGFR1_Spur -----------A-----------C-----------------------MGPVDRSS-R-GS : .. KDR_Hsap QSSASSGFVEEKS-------------L-S---DVEE------------------------ FLT4_Hsap DRVLFARFSKTEGG------------A-R---RASP------------------------ FLT1_Hsap ESFASSGFQEDKS-------------L-S---DVEE------------------------ CG3277_Dmel PKSQSVNYIELKAS-------------SQ-TIEMPQEDSTAHMNGIRQPHPSFAESKLVA Pvr_Dmel PRSGTRAGRTGSGTATYSYDRQMDTCATV-MTTVPEDDQIMS------------------ KDR_Mmus QSSASSGFVEEKS-------------L-S---DVEE------------------------ FLT4_Mmus DRALFTRFLMGKGS------------A-R---RAPL------------------------ FLT1_Mmus -SVTSSSFPEDRS-------------V-S---DVEG------------------------ VEGFR2_Spur STGASNTFQTSSGS---------ERRMKAVYDQIIP------------------------ VEGFR1_Spur SRGGGDGFMGARGG--------------S-TLEVGD------------------------ . KDR_Hsap ---------------------EEAPEDLY-KDFLTLEHLICYSFQVAKGMEFLASRKCIH FLT4_Hsap ---------------------DQEAEDLW-LSPLTMEDLVCYSFQVARGMEFLASRKCIH FLT1_Hsap ---------------------EEDSDGFY-KEPITMEDLISYSFQVARGMEFLSSRKCIH CG3277_Dmel LGLTSWAKSVNENLISATY-TIVEDEDAF-EYILDNKELHNFALQIANGMRFLEEQEITH Pvr_Dmel -----------NNSVQPAWRSNYKTDSTE-AMTVTTVDLISWAFQVARGMDYLSSKKVLH KDR_Mmus ---------------------EEASEELY-KDFLTLEHLICYSFQVAKGMEFLASRKCIH FLT4_Mmus ---------------------VQEAEDLW-LSPLTMEDLVCYSFQVARGMEFLASRKCIH FLT1_Mmus ---------------------DEDYSEIS-KQPLTMEDLISYSFQVARGMEFLSSRKCIH VEGFR2_Spur ---------------------EEVFSPLQ-DDPINSQDLLCYSFQVARGMEFLASKNVIH VEGFR1_Spur ---------------------DDVFEYMEKEQPLTLKDLICYSYQVARGMEFLTSKKCIH . : .* :: *:*.** :* .:: * KDR_Hsap RDLAARNILLSEKNVVKICDFGLARD-IYKDPDYVRKG-DARLPLKWMAPETIFDRVYTI FLT4_Hsap RDLAARNILLSESDVVKICDFGLARD-IYKDPDYVRKG-SARLPLKWMAPESIFDKVYTT FLT1_Hsap RDLAARNILLSENNVVKICDFGLARD-IYKNPDYVRKG-DTRLPLKWMAPESIFDKIYST CG3277_Dmel RDLAARNVLIDSNKTLKISDFGLSRHGIYT-----NTR-TRKLPLRWLSIEAIRENVYSS Pvr_Dmel GDLAARNILLCEDNVVKICDFGLARS-MYRGDNYKKSE-NGKLPIKWLALESLSDHVFST KDR_Mmus RDLAARNILLSEKNVVKICDFGLARD-IYKDPDYVRKG-DARLPLKWMAPETIFDRVYTI FLT4_Mmus RDLAARNILLSESDIVKICDFGLARD-IYKDPDYVRKG-SARLPLKWMAPESIFDKVYTT FLT1_Mmus RDLAARNILLSENNVVKICDFGLARD-IYKNPDYVRRG-DTRLPLKWMAPESIFDKVYST VEGFR2_Spur RDLAARNVLVTENYTLKICDFGLAKH-LYDDPDYVASGKQGRLPIKWMAPESIFDKVFTT VEGFR1_Spur RDLAARNVLLAENNIVKICDFGLARD-IYSDPDYVTQT-GGRLPIKWMAPESIFDKVFTI ******:*: .. :**.****:: :* :**::*:: *:: :.::: KDR_Hsap QSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWH FLT4_Hsap QSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWS FLT1_Hsap KSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWH CG3277_Dmel KSDIWAYGVVLWEIGTLGASPYPTISND-ELIPFLMAGNRLERPEICTPQVYTIMLQCWL Pvr_Dmel YSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWR KDR_Mmus QSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWH FLT4_Mmus QSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLKDGTRMRAPELATPAIRHIMQSCWS FLT1_Mmus KSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWH VEGFR2_Spur YSDVWAYAVFLWEVFSLGGSPYPGIQIDEKFYNKIKNGYRMNAPDYAPPGVYDTMLECWT VEGFR1_Spur YSDVWSFGVFMWECFALGGSPYPGVVVDEEFYNRLKSGYRMYTPDYAPIEIYHVMLDCWH **:*::.:.:** :*. *** : : .: : * *: *. : * .** KDR_Hsap GEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSME------EDSGLSLPTS- FLT4_Hsap GDPKARPAFSELVEILGDLLQGRGLQEEEEVCM-APRSSQSSE------EGSFSQVSTM- FLT1_Hsap RDPKERPRFAELVEKLGDLLQANVQQDGKDYI--PINAILTG--------NSGFTYSTP- CG3277_Dmel EEPEERPTFDALYKVLSPKT------TYVDINS----------------------LSDD- Pvr_Dmel KNPESRPLFAELEKRFANMLGEDVASHYLDLNN-PYM---QSN------IEYMKKQSTD- KDR_Mmus EDPNQRPSFSELVEHLGNLLQANAQQDGKDYIVLPMSETLSME------EDSGLSLPTS- FLT4_Mmus GDPKARPAFSDLVEILGDLLQGGGWQEEEEERM-ALHSSQSSE------EDGFMQASTT- FLT1_Mmus KDPKERPRFAELVEKLGDLLQANVQQDGKDYI--PLNAILTR--------NSGFTYSTP- VEGFR2_Spur PEPEARPSFSILAVRLGDMLEANVASDYIELNM-PFEQAN---------NEILQELPS-- VEGFR1_Spur TEPKERPHFSELVHKLGDQLAANVKQEYLDLDC-AYDEQVASRPISFYNEDEEEDASTSH :*. ** * * :. : . KDR_Hsap ----PVS-C-MEEEEV-CDPKFHYDNTAGI----------SQYLQNSKR----------- FLT4_Hsap ----ALH-I-AQADAEDSPPSLQR-HSLAA-----------RYYNWVSFPGCLARG---- FLT1_Hsap ----AFSED-FFKESI-SAPKFNSGSSDDV-----------RYVNAFKF----------- CG3277_Dmel ----YV------------------------------------------------------ Pvr_Dmel ----YLA---LMGSPDELAP-------AAP-----------RYVNGHIVP---------- KDR_Mmus ----PVS-C-MEEEEV-CDPKFHYDNTAGI----------SHYLQNSKR----------- FLT4_Mmus ----ALH-I-TEADADDSPPSMHC-HSLAA-----------RYYNCVSFPGRLARG---- FLT1_Mmus ----TFSED-LFKDGF-ADPHFHSGSSDDV-----------RYVNAFKF----------- VEGFR2_Spur -----PHEH---------TPL-------LQPHPPTHFKP--------------------- VEGFR1_Spur DGQVTLGEDALQVEADISLPSTS-GYQPNHPSTSSTFQLEDERPVCASLEGRTVSSIHAS KDR_Hsap -----------------KSRPVSVKTFEDIPLEEPEVKVIPDD-NQTDSGMVLASEELKT FLT4_Hsap ---------------AETRGSSRMKTFEEFPMT-PTTYKGSVD-NQTDSGMVLASEEFEQ FLT1_Hsap -----------------M-SLERIKTFEELL---PNATSMFDD-YQGDSSTLLASPMLKR CG3277_Dmel ------------------------------------------------------------ Pvr_Dmel -------------------DI----RIEELP---DDYMEMSRD-SDPDACTAIFSPTRLE KDR_Mmus -----------------KSRPVSVKTFEDIPLEEPEVKVIPDD-SQTDSGMVLASEELKT FLT4_Mmus ---------------TKTPGSSRMKTFEELPMT-PTTYKASMD-NQTDSGMVLASEEFEE FLT1_Mmus -----------------M-SLERIKTFEELS---PNSTSMFED-YQLDTSTLLGSPLLKR VEGFR2_Spur -------SP-ANSTP---NT-------------PPVT-----------THMV-PSDSGVS VEGFR1_Spur LTDISSSEPCDEEDDTGGESTKSSTTSARLPLHRPNSLSALDSLQQTMTNPVFHHHHHHH KDR_Hsap L-----------------EDRTKLSPSFG-G-------------------------MVPS FLT4_Hsap I-----------------ESRHRQESGFS-C-------------------------KGPG FLT1_Hsap FTWT--------------DSKPKASLKID-L-------------------------RVTS CG3277_Dmel ------------------------------------------------------------ Pvr_Dmel GESSDFPDFSSETTFNFPGARQSPTLSNN-LNSGSSKPLRKKNGMPTVDVADQAPEEIPM KDR_Mmus L-----------------EDRNKLSPSFG-G-------------------------MMPS FLT4_Mmus L-----------------ESRHRPEGSFS-C-------------------------KGPG FLT1_Mmus FTWT--------------ETKPKASMKID-L-------------------------RIAS VEGFR2_Spur A-----------------QDRDPSLPSNGMG-------------------------SQPF VEGFR1_Spur H-----------------SSNHHHHHNHG-N-------------------------NSTS KDR_Hsap KSRESV----ASEG--SNQTSGYQ---SG--------------YHSDDTDTTVYSSEEA- FLT4_Hsap QNVAVTRAHPDSQGRRRRPERGAR---G---------------------GQVFYNSEYG- FLT1_Hsap KSKESG----LSDV--SRPSFCHS---SC--------------GHVSEG-KRRFTYDHA- CG3277_Dmel ------------------------------------------------------------ Pvr_Dmel LHRSST----GSDG---SPEQGRR---FNQALKQQYVTPTPSPRHHVETKLNGEPSENYV KDR_Mmus KSRESV----ASEG--SNQTSGYQ---SG--------------YHSDDTDTTVYSSDEA- FLT4_Mmus QHMDIPRGHPDPQGRRRRPTQGAQ---G---------------------GKVFYNNEYG- FLT1_Mmus KSKEAG----LSDL--PRPSFCFS---SC--------------GHIRP-----VQDDES- VEGFR2_Spur LSKDAV----QNNT--TVQEINELEEEMN--------------SHEDDV----FLAPEA- VEGFR1_Spur KSEESV----SSDS--S---SGFR---SG--------------GYGSDV----NDEPPP- KDR_Hsap ELLKLI----------EIGVQTGS-TAQILQPD-----SGTTLSSPPV FLT4_Hsap ELSEPS-------------------EEDHCSPSA----RVTFFTDNSY FLT1_Hsap ELERKI----------A---------CCSPPPDY---NSVVLYSTPPI CG3277_Dmel ------------------------------FP---------PISENRE Pvr_Dmel NMKPPRKNIPGKTTTGGGGAAAGASTEAFSNPSYQPLSTVNEKEQRRY KDR_Mmus GLLKMV----------D----------AAVHAD-----SGTTLRSPPV FLT4_Mmus EVSQPC-------------------TEGDCCPSA----GSTFFADSSY FLT1_Mmus ELGKE-----------S---------CCSPPPDY---NSVVLYSSPPA VEGFR2_Spur TTNGLT----------GT--------------------H--TEAHLTV VEGFR1_Spur EYSKVM----------QVALH----------KET---SLFWPRGTNGQ