CLUSTAL W (1.83) multiple sequence alignment HSER_Hsap_RGC LKIDDDK----------------------------------R---R-------------- CG10738_Dmel_RGC TT---------------------------------------------------------- CG9783_Dmel_RGC TTANGKS----------------------------------GSS-------ATG------ Gyc32E_Dmel_RGC QSIL------------------VV-----------------GEPN--------------- Gyc76C_Dmel_RGC LEIEGLLWKIDPNEIKGYSGNEIV-----------------SSPSK--VSLMSA------ CG4224_Dmel_RGC Q----------------------------------------------------------- CG3216_Dmel_RGC P----------------------------------------------------------- KSGC_Mmus_RGC SLVK-------------------R------------------------------------ HSER_Mmus_RGC LKIDDDR----------------------------------R---R-------------- CYGX_Mmus_RGC RSVVD------------------G-----------------G-SPR---SVTQG------ CYGF_Mmus_RGC FQIISEV---------------QS-----------------GRSPR--LSFSSG------ CYGD_Mmus_RGC RSAS-------------------------------------------------------- ANPb_Mmus_RGC GSRLTLS---------------L-------------------RG------SSYG------ ANPa_Mmus_RGC GSRLTLS---------------G-------------------RG------SNYG------ odr-1_Cele_RGC FGSYALV---------------GT------------------------------------ gcy-9_Cele_RGC SKQNGLI---------------AA-----------------K------------------ gcy-8_Cele_RGC SRNHAIV---------------GT------------------------------------ gcy-7_Cele_RGC ----------------------------------QINSKQKGKGEHSVRSLQSGTSTLSS gcy-6_Cele_RGC ----------------------------------E------------------------- gcy-5_Cele_RGC QM--------------------------------FE------------------------ gcy-4_Cele_RGC SKSGDTM---------------TSEFKETYTIQYLE------------------------ gcy-3_Cele_RGC ----------------------------------FE------------------------ gcy-27_Cele_RGC FGSYALI---------------GT------------------------------------ gcy-25_Cele_RGC ------------------------------------------------------------ gcy-23_Cele_RGC VKHHAVV---------------GT------------------------------------ gcy-22_Cele_RGC ----------------------------------N------------------------- gcy-21_Cele_RGC EG---------------------------------------------------------- gcy-20_Cele_RGC ----------------------------------H------------------------- gcy-2_Cele_RGC ----------------------------------YE------------------------ gcy-19_Cele_RGC -----------------------------------D------------------------ gcy-18_Cele_RGC QKQHAII---------------GV------------------------------------ gcy-17_Cele_RGC ----------------------------------L------------------------- gcy-15_Cele_RGC EG---------------------------------------------------------- gcy-14_Cele_RGC ----------------------------------Q------------------------- gcy-13_Cele_RGC ----------------------------------YM------------------------ gcy-12_Cele_RGC YEVRRVV---------------GG-----------------VN-NE-----STA------ gcy-11_Cele_RGC ------------------------------------------------------------ gcy-1_Cele_RGC ----------------------------------YE------------------------ daf-11_Cele_RGC MEEKQRL---------------QS------------------------------------ C04H5.4_Cele_RGC ------------------------------------------------------------ CYGF_Hsap_RGC FQITSEV---------------QS-----------------GRSPR--LSFSSG------ ANPb_Hsap_RGC GSRLTLS---------------L-------------------RG------SSYG------ ANPa_Hsap_RGC GSRLTLS---------------G-------------------RG------SNYG------ CYGD_Hsap_RGC ARSMS------------------------------------------------------- T01A4.1_Cele_RGC AQN--------------------------------------------------------- Npr1_Spur_RGC ------------------------------------------------------------ Npr2_Spur_RGC ------------------------------------------------------------ Gcy3_Spur_RGC ------------------------------------------------------------ Npr3_Spur_RGC ------------------------------------------------------------ Npr4_Spur_RGC ------------------------------------------------------------ Gcy1_Spur_RGC ------------------------------------------------------------ Gcy2_Spur_RGC ------------------------------------------------------------ Npr5_Spur_RGC ------------------------------------------------------------ AqueK220_Aque_RGC ------------------------------------------------------------ AqueK221_Aque_RGC ------------------------------------------------------------ AqueK222_Aque_RGC ------------------------------------------------------------ HSER_Hsap_RGC -----------DTIQR------------------LRQCKYDKKR--V-ILKDLKH----- CG10738_Dmel_RGC --------------IF------------------TPIGLYKGQL--Y-AIKKVRK----- CG9783_Dmel_RGC ----SLAR--HNPAHL------------------DMRARYNGDL--V-QLKEVNING--- Gyc32E_Dmel_RGC ------------KRSF------------------TNIALFRGNI--V-AMKKIHK----- Gyc76C_Dmel_RGC ----QSYGSRWTNQFV------------------TSTGRLRGAV--V-RIKELKFP---- CG4224_Dmel_RGC --------------IF------------------IPVGMFRKSK--V-AIKPVEVD---N CG3216_Dmel_RGC -------------QVY------------------TTIGQFKGER--V-AIKKVNV----- KSGC_Mmus_RGC --------HQDEELFF------------------APVGLYQGNQ--V-ALCYIGDEA--- HSER_Mmus_RGC -----------DTIQR------------------VRQCKYDKKK--V-ILKDLKH----- CYGX_Mmus_RGC ----SARSLP-AFLEH------------------TNVALYQGEW--V-WLKKFEAGV--- CYGF_Mmus_RGC ----SLT--P-ATYEN------------------SNIAIYEGDW--V-WLKKFPPGDFGD CYGD_Mmus_RGC ----DIRSVPSQPQES------------------TNVGLYEGDW--V-WLKKFPGEH--- ANPb_Mmus_RGC ----SLMTAHGKYQIF------------------ANTGHFKGNV--V-AIKHVNK----- ANPa_Mmus_RGC ----SLLTTEGQFQVF------------------AKTAYYKGNL--V-AVKRVNR----- odr-1_Cele_RGC ---------------------------------------QRAE-----YVQFKQI----- gcy-9_Cele_RGC ------------------------------------QAVSNGVK--L-AIKRYQ-Q---V gcy-8_Cele_RGC ---------------------------------------NTHA----IYHKYVQR----- gcy-7_Cele_RGC RTTVSFKTESRNFLFF------------------SLQRESDYEP--V-VAKKHA-Y---R gcy-6_Cele_RGC -----------------------------------------MER--V-AAKKHS-I---R gcy-5_Cele_RGC -----------------------------------------KDL--V-LTTKHH------ gcy-4_Cele_RGC -----------------------------------------NDL--V-LTTAHQ------ gcy-3_Cele_RGC -----------------------------------------KDM--V-LTMKFQ------ gcy-27_Cele_RGC ---------------------------------------QRAE-----FIQFRQI----- gcy-25_Cele_RGC -------------------------------------------K--V-SVKRHV-Q---R gcy-23_Cele_RGC ---------------------------------------NTHA----SFHLYPQR----- gcy-22_Cele_RGC -----------------------------------------NDS--V-VARKHN-F---- gcy-21_Cele_RGC ------------------------------------------RT--V-ALKRIYR----- gcy-20_Cele_RGC -----------------------------------------QEV--V-AAKKHD-L---- gcy-2_Cele_RGC -----------------------------------------KEM--V-LTAKYQ------ gcy-19_Cele_RGC -----------------------------------------KEP--V-LSTAHP------ gcy-18_Cele_RGC ---------------------------------------NTHT----TYHRYKQR----- gcy-17_Cele_RGC -----------------------------------------LKVRQI-GVLTPT-S---M gcy-15_Cele_RGC ------------------------------------------RT--V-ALKRIYR----- gcy-14_Cele_RGC -----------------------------------------QDI--L-AAMKHD-L---- gcy-13_Cele_RGC -----------------------------------------NEP--V-LARKYQ-L---- gcy-12_Cele_RGC ----SLMQ--SDVMQFAKTKTPWWSKAPVQGTGMRGLASYKGTL--V-GLKDLMYG---R gcy-11_Cele_RGC ----------------------------------------ENTL--V-TVRKIN-----K gcy-1_Cele_RGC -----------------------------------------KEM--V-LTAKYQ------ daf-11_Cele_RGC -----LAR--T-----------------------KHIATVDQVY--VLADKYVMR----- C04H5.4_Cele_RGC ------------------------------------------------------------ CYGF_Hsap_RGC ----SLT--P-ATYEN------------------SNIAIYEGDW--V-WLKKFSLGDFGD ANPb_Hsap_RGC ----SLMTAHGKYQIF------------------ANTGHFKGNV--V-AIKHVNK----- ANPa_Hsap_RGC ----SLLTTEGQFQVF------------------AKTAYYKGNL--V-AVKRVNR----- CYGD_Hsap_RGC ----DIRSGPSQHLDS------------------PNIGVYEGDR--V-WLKKFPGDQ--- T01A4.1_Cele_RGC -----------NTQIY------------------TKTAIFKGVV--V-AIKKLNIDPKKY Npr1_Spur_RGC -----------------------------------------GNV--I-AIKRVNR----- Npr2_Spur_RGC -----------------------------------------GRL--V-VIRRIEK----- Gcy3_Spur_RGC -------------------------------------------L--V-AIKKIHK----- Npr3_Spur_RGC ------------------------------------------------------------ Npr4_Spur_RGC ----------------------------------------NGQT--V-AVKMIAK----- Gcy1_Spur_RGC ------------------------------------------------------------ Gcy2_Spur_RGC ------------------------------------------------------------ Npr5_Spur_RGC ------------------------------------------------------------ AqueK220_Aque_RGC ------------------------------------------------------------ AqueK221_Aque_RGC ------------------------------------------KI--V-KVHKMK-M---- AqueK222_Aque_RGC -----------------------------------------GKT--V-AIKKLNYR---S HSER_Hsap_RGC NDG-NFTEKQKIELNKL-LQIDYYNLTKFYGTVKLD----------TMIF-GVIEYCERG CG10738_Dmel_RGC KSV-DITREMKKELKLL-RDARHDNICAFIGACTDP----------PNIC-IISEYCTRG CG9783_Dmel_RGC -SA-ELRTKAMDLLVMA-HGLRHENINPLIGWLSDP----------NRTA-MVFDYCSRG Gyc32E_Dmel_RGC KSV-DITRSIRKELKLM-REVRHENIINFIGASTDH----------GSVI-IFTTYCARG Gyc76C_Dmel_RGC RKR-DISREIMKEMRLL-RELRHDNINSFIGASVEP----------TRIL-LVTDYCAKG CG4224_Dmel_RGC VQG-LLTRSLMLELKRM-KDLQHDHLVKFYGACLDQ----------RRSF-LLTEYCPKG CG3216_Dmel_RGC KKV-DLTPQLLWEIKQA-RDVSHENTVRFVGACIDLP--------RPTVL-ILTEYCSRG KSGC_Mmus_RGC EAW-VKKPTVRREVCLM-CELKHENIVPFFGVCTEP----------PNIC-IVTQYCKKG HSER_Mmus_RGC SDG-NFSEKQKIDLNKL-LQSDYYNLTKFYGTVKLD----------TRIF-GVVEYCERG CYGX_Mmus_RGC -AP-DLRPSSLSFLRKL-REMRHENVTAFLGLFVGP----------GVSA-MVLEHCARG CYGF_Mmus_RGC -IK-SIKSSASDVFEMM-KDLRHENVNPLLGFFYDS----------GMFA-IVSEFCSRR CYGD_Mmus_RGC -HM-AIRPATKTAFSKL-RELRHENVALYLGLFLAGTADSPATPGEGILA-VVSEHCARG ANPb_Mmus_RGC KRI-ELTRQVLFELKHM-RDVQFNHLTRFIGACIDP----------PNIC-IVTEYCPRG ANPa_Mmus_RGC KRI-ELTRKVLFELKHM-RDVQNEHLTRFVGACTDP----------PNIC-ILTEYCPRG odr-1_Cele_RGC RKI-NFPETTLDYLYSL-KQLQHDNLAKFYGIQVNDD--------IMTMT-ILHTLVERG gcy-9_Cele_RGC RNI-TFPKSELRLLKEL-KICENDNLNKFYGISFNQQ---------NEFI-VMWVLCSRG gcy-8_Cele_RGC RPI-VFNRAD------K-TLIxHDNINPFLGMVWNER---------EEML-LVWKFCSRG gcy-7_Cele_RGC PRLD-D--DKCTFMRSL-RNLDQDNLNRFIGLCLDG----------PQML-SVWRFCSRG gcy-6_Cele_RGC MVFDNKTCATMRQVVEM-RLIDHANLNKFIGMSLDA----------PQLY-SVWRFCSRG gcy-5_Cele_RGC -SM-QMNKEEKEKFVKL-RKLEHDNLNKFIGLSIDG----------PQFV-AVWKMCSRG gcy-4_Cele_RGC -VQ-ELSQAEMMKFVKL-RKLDHENLNKFIGLSIDG----------SRFV-SVWKMCSRG gcy-3_Cele_RGC -YM-NLNKADMDKFVKL-RKLDHENLNKFIGLSIDS----------SQFI-SVTKLCSRG gcy-27_Cele_RGC KHI-DITNASLDFLYNL-KQLKHDNLANFYGIQLNDD--------LNTMT-ILHALVERG gcy-25_Cele_RGC RAI-TFSRQEMEMLNQL-KYMSHTNINPFTGICFNQG---------SELI-VMWQFTTRY gcy-23_Cele_RGC RPI-VFNRQDLQLLNQM-KQAVHDNLNPFLGMSFNEK---------EEMV-VLWKFCSRG gcy-22_Cele_RGC -RA-TFTKNDRAMFRKM-RNVDNDNLCKFIGLSLDS----------PTLI-SIWRYCSRG gcy-21_Cele_RGC SDV-EFTRSIRLEIAKL-QESVNSNVIEFVGMVVQSP----------DVF-VVYELAQRG gcy-20_Cele_RGC -LV-LFDANQKSEFRQM-RNFDNDNLNKFIGLCLDG----------PQLL-SLWRFCSRG gcy-2_Cele_RGC -YT-HLTKADKERFVKM-RKLDHENINRFIGLSIDS----------AHFI-AVTKLCSRG gcy-19_Cele_RGC -AS-NLIRTDYDTFVRL-RKLDHENVNKFVGMSIDG----------PEYL-AVWKLCMRG gcy-18_Cele_RGC RPI-KFIKEDMQLLTQM-KQAVHDNLNPFLGAAFNEK---------EEML-VLWKFCSRG gcy-17_Cele_RGC PYL-KPKLSYFSSMHHM-RSLDHDNLNKFIGLCLNS----------QQLL-SIWRYCSRG gcy-15_Cele_RGC SDV-EFTRSNRLEIAKL-QESVNSNVIEFVGMVVQSP----------DVF-VVYELAQRG gcy-14_Cele_RGC -IL-QFDAEQKAEFRQM-RNFDNDNLNKFIGLCLDG----------PQLF-SLWRFCSRG gcy-13_Cele_RGC -RV-PIFKQDRSELRML-RSIEHDNVNRFIGLSIDG----------PVYM-SFWRYCSRG gcy-12_Cele_RGC KPK-DLTREAKKELRAM-RQLAHPNVNNFLGIIVCQ----------YSVT-VVREYCSKG gcy-11_Cele_RGC TQL-KLTREMKQEIDLL-MNETHENLNRFFGLINES----------DLIF-TIHSYGPRK gcy-1_Cele_RGC -YT-HLTKADKERFVKM-RKLDHENINRFIGLSIDS----------AHFI-SVTKLCSRG daf-11_Cele_RGC DKL-RYDKIDINLLYQMKSHLQHDNLNSFVGITIDKA---------SHMY-IIWNQCFRG C04H5.4_Cele_RGC ------------------KQAVHDNINPFIGVSFNEK---------SELL-LLWKFCSRG CYGF_Hsap_RGC -LK-SIKSRASDVFEMM-KDLRHENINPLLGFFYDS----------GMFA-IVTEFCSRG ANPb_Hsap_RGC KRI-ELTRQVLFELKHM-RDVQFNHLTRFIGACIDP----------PNIC-IVTEYCPRG ANPa_Hsap_RGC KRI-ELTRKVLFELKHM-RDVQNEHLTRFVGACTDP----------PNIC-ILTEYCPRG CYGD_Hsap_RGC -HI-AIRPATKTAFSKL-QELRHENVALYLGLFLARGAEGPAALWEGNLA-VVSEHCTRG T01A4.1_Cele_RGC PRL-DLSRAQLMELKKM-KDLQHDHITRFTGACIDF----------PHYC-VVTEYCPKG Npr1_Spur_RGC QRV-ELNRNVLMEIKHV-RDLQHDHVIKFIGACIDA----------PNIS-IMTEYCPKG Npr2_Spur_RGC TKL-DLTREVLKELNYM-RQVEHNNLVRFVGACVDA----------PNIS-IISEYCPKG Gcy3_Spur_RGC RHV-DLTRSVRKELKII-RDLRHPHLNQFIGACVDP----------PNIC-TITEYCPKG Npr3_Spur_RGC ----------------M-RNLEHTNVVRFVGACVDP----------PDQA-ILTEYCPRG Npr4_Spur_RGC NSF-TLDKRIRKEVKQV-RDLQHSNLCKFAGGCIEVP----------NVS-IITEYCPKG Gcy1_Spur_RGC -------RAVRTELKIM-RDMRHDNICPFIGACIDR----------PHIS-ILMHYCAKG Gcy2_Spur_RGC ------------------------------------------------------------ Npr5_Spur_RGC -------KAIKRELKEM-RWLVHDNINRFLGLCFPST-------SGDMFY-HVSEFSPKG AqueK220_Aque_RGC ------------KILTI-LDFKHDNICPFVGGILQG----------SLITGLMYEYCTRG AqueK221_Aque_RGC NIS-TLDLNLRKTMLQI-LNFDHENICPFIGCILQG----------PTIVGMMHEYCSHG AqueK222_Aque_RGC REL-QLTKTLRKEVMQI-RSLDHANVCRFIGATLRSS---------ENVI-ILTEYCPKG HSER_Hsap_RGC SLREVLNDTISYPDGTF--MDWEFKISVLYDIA-------KGMSYLHS-SKTEVHGRLKS CG10738_Dmel_RGC SLKDILEN-----EDVK--LDNMFIASMVADII-------RGVIYLHD-SPIRFHGALCT CG9783_Dmel_RGC SLQDVLIM-----DEIK--LDWSFRLSLLTDLV-------RGMRYLHT-SPLRVHGALTS Gyc32E_Dmel_RGC SLEDVLAN-----EDLH--LDHMFISSLVSDIL-------KGMIYLHD-SEIISHGNLRS Gyc76C_Dmel_RGC SLYDIIEN-----EDIK--LDDLFIASLIHDLI-------KGMIYIHN-SQLVYHGNLKS CG4224_Dmel_RGC SLQDILEN-----EQFQ--LDWMFRLSLMHDIV-------RGMQFLHS-SDIRSHGNLKS CG3216_Dmel_RGC SLKDVLEN-----EAIE--LDWNFRMSLIHDIV-------KGMNYLHN-SDVAAHGKLRS KSGC_Mmus_RGC SLQDVMRN-----SDHE--IDWIFKLSFAYDIV-------NGLLFLHG-SPLRSHGNLKP HSER_Mmus_RGC SLREVLNDTISYPDGTF--MDWEFKISVLNDIA-------KGMSYLHS-SKIEVHGRLKS CYGX_Mmus_RGC SLEDLLQN-----ENLR--LDWTFKASLLLDLI-------RGLRYLHH-RRF-PHGRLKS CYGF_Mmus_RGC SLEDILTN-----DDVK--LDWMFKSSLLLDLI-------KGMKYLHH-REF-IHGRLKS CYGD_Mmus_RGC SLHDLLAQ-----REIK--LDWMFKSSLLLDLI-------KGMRYLHH-RGV-AHGRLKS ANPb_Mmus_RGC SLQDILEN-----DSIN--LDWMFRYSLINDLV-------KGMAFLHN-SIISSHGSLKS ANPa_Mmus_RGC SLQDILEN-----ESIT--LDWMFRYSLTNDIV-------KGMLFLHN-GAIGSHGNLKS odr-1_Cele_RGC TLEEFCLD-----RDFG--MDDTFKSAFMRDIL-------KGLQYLHK-SSIGYHGHLQA gcy-9_Cele_RGC SLEDILFN-----DELK--LGRNFQVSFAKDVV-------KGLNFLHT-SPLLHHGMLCL gcy-8_Cele_RGC TLQDIIYN-----ESIQ--LDTKFHGAFIRDIL-------AGLEYLHA-SQIGYHGSLTP gcy-7_Cele_RGC SIADVILK-----ATIQ--MDNFFIYSLIKDMV-------HGLVFLHG-SMVGYHGMLTS gcy-6_Cele_RGC SLADVIRK-----ASMQ--MDGFFIYSLMKDII-------NGLTWIHE-SSHEFHGMLTS gcy-5_Cele_RGC SLQDIIAR-----GNFS--MDGFFMFCIITDIA-------EGMNFLHK-SFLHLHGNLRS gcy-4_Cele_RGC SLQDIISK-----GSFS--MDYFFMFCMIRDIA-------EGLHYIHK-SFLRHHGNLRS gcy-3_Cele_RGC SLLDILYK-----GNFS--MDFFFMYCIIKDVA-------EGMSYLHK-SFLRLHGNLRS gcy-27_Cele_RGC TLEEFCLD-----RDFG--MDETFKSAFMRDIL-------KGLQYLHL-SPVAYHGHLHA gcy-25_Cele_RGC SLEDLIFV-----KEQK--FGRNFQSTFIKHIV-------HGINYIHN-SSIKVHGALYL gcy-23_Cele_RGC TIQDMIYN-----QEVS--LDSKFHGAFIRDIT-------LGLEYLHS-SIIGYHGSLTP gcy-22_Cele_RGC SLQDVIAK-----GSLQ--MDWFFKYSLMRDVA-------DAIYYLHH-SPIGPHGWLSS gcy-21_Cele_RGC SLKDILDN-----DDMP--LDDVFRSQMTKDII-------AGLEYLHS-SPIGCHGRLKS gcy-20_Cele_RGC SLSDVISK-----SSMQ--MDSFFMFSLIRDIS-------NGLYFIHS-SFLKCHGQLTS gcy-2_Cele_RGC SLQDILSR-----GNFS--MDYFFMFCIIRDVA-------KGLEYLHK-TFLRLHGNLRS gcy-19_Cele_RGC SLQDIIGQ-----GNFS--IDPFFMFCVIRDMA-------EGLKYLHN-SFLHVHANLRS gcy-18_Cele_RGC TIQDIIYN-----ANVV--LDEKFHGAFVRDIT-------LGLEYLHA-SPIGYHGSLTP gcy-17_Cele_RGC SLADVISR-----SSMQ--MDSFFMLSLIRDIA-------NGLGFIHT-SMLHFHGYLSS gcy-15_Cele_RGC SLKDILDN-----DDMP--LDDVFRSQMTKDII-------AGLEYLHS-SPVGCHGRLKS gcy-14_Cele_RGC SLSDVISK-----SSMQ--MDSFFMFSLIRDIS-------NGLLFIHN-SFLKCHGHLTS gcy-13_Cele_RGC SIKDVIAK-----SSIN--MDGFFIYCLIKDIASVSRHENPGLQYIHH-SPIKQHGSLTS gcy-12_Cele_RGC SLHDILRN-----ENLK--LDHMYVASFVDDLV-------KGMVYIHD-SELKMHGNLKS gcy-11_Cele_RGC SLMDLLRN-----DDLR--LDRMFKVSFVEDVV-------KGLQFLHEGSKIGYHGNLKS gcy-1_Cele_RGC SLQDILSR-----GNFS--MDYFFMFCIIRDVA-------KGLEYLHK-TFLRLHGNLRS daf-11_Cele_RGC SLHDHIFT-----KERQRGTATRFEGLFLRDIL-------KGLEYIHA-SAIDFHGNLTL C04H5.4_Cele_RGC TLQDVIYC-----EKFA--MDEKFQGAFVRDIT-------MGLEYLHS-SPIGYHGGLAC CYGF_Hsap_RGC SLEDILTN-----QDVK--LDWMFKSSLLLDLI-------KGMKYLHH-REF-VHGRLKS ANPb_Hsap_RGC SLQDILEN-----DSIN--LDWMFRYSLINDLV-------KGMAFLHN-SIISSHGSLKS ANPa_Hsap_RGC SLQDILEN-----ESIT--LDWMFRYSLTNDIV-------KGMLFLHN-GAICSHGNLKS CYGD_Hsap_RGC SLQDLLAQ-----REIK--LDWMFKSSLLLDLI-------KGIRYLHH-RGV-AHGRLKS T01A4.1_Cele_RGC SLEDILEN-----EKIE--LDKLMKYSLLHDLV-------KGLFFLHN-SEIRSHGRLKS Npr1_Spur_RGC SLQDILEN-----DSIE--LDELFKYSLMYDIV-------KGMLYLHN-SVIQTHGNLKS Npr2_Spur_RGC SLQDIVEN-----DALK--LDNMFKNSLITDVM-------RGLHYLHS-SVIMLHSRLSS Gcy3_Spur_RGC SLQDILEN-----DEVK--LDSMFIASLIGDIL-------KGLSCLHA-SETHSHGNLKS Npr3_Spur_RGC SLQDILEN-----DQLK--LDLMFRQSLLMDAV-------RGLNYIHD-SVIGVHGRLTS Npr4_Spur_RGC ALSDVLLN-----EDVP--LNWSFRFSFCMDVA-------RGMHYMHN-NKL-YHGKLTS Gcy1_Spur_RGC SLQDILEN-----DDIK--LDSMFLSSLIADLV-------KGIVYLHS-SEIKSHGHLKS Gcy2_Spur_RGC ---DILEN-----DDIK--LDEMFIASLVSDIV-------KGMRHLHS-TEIRTHGNLKS Npr5_Spur_RGC SLKSILAN-----DDVN--LDLSFKASFIRDLA-------RGMQFLHA-SEIKNHGVLSS AqueK220_Aque_RGC SLYDLLTN-----PHIG--FNKSFRQSFAIDCS-------EGLAYLHG-RKA-IHGRLTS AqueK221_Aque_RGC SLYEVLRN-----PNIV--FDKQFRVLFATDII-------KGLTYLHS-HKL-THGRLSS AqueK222_Aque_RGC SLNDVLQN-----DDIP--LNWGFRFSFVTDIS-------RGLAYLHS-KRI-VHHRLMS . . . .: :* * * HSER_Hsap_RGC TNCVVDSRMVVKITDFGCNSILP------------------------------------- CG10738_Dmel_RGC SNCLVDSRWVVKLTDFGLFAFKQGIEDSST-------------------------D---M CG9783_Dmel_RGC RNCVVDARWVLKITDYGLNSFYESQGLP-P------------------------------ Gyc32E_Dmel_RGC SNCLIDSRWVCQISDFGLHELKAGQEEPNK------------------------------ Gyc76C_Dmel_RGC SNCVVTSRWMLQVTDFGLHELRQCAENES------------------------------I CG4224_Dmel_RGC SNCVVDSRFVLKITDFGLHTLRRTRFDLES-------------------------DGGNC CG3216_Dmel_RGC CNCLIDGRFVLKISDFGLRTLTTPSDFV-R------------------------------ KSGC_Mmus_RGC SNCLVDSHMQLKLSGFGLWEFKHGSTWRS--------------------------Y---N HSER_Mmus_RGC TNCVVDSRMVVKITDFGCNSILP------------------------------------- CYGX_Mmus_RGC RNCVVDTRFVLKITDHGYAEFLESHCSS-R------------------------------ CYGF_Mmus_RGC RNCVVDGRFVLKVTDYGFNDILEMLRLS-E------------------------------ CYGD_Mmus_RGC RNCVVDGRFVLKVTDHGHGRLLEAQRVL-P------------------------------ ANPb_Mmus_RGC SNCVVDSRFVLKITDYGLASFRSTAEPD-D------------------------------ ANPa_Mmus_RGC SNCVVDGRFVLKITDYGLESFRDPE-PE-Q------------------------------ odr-1_Cele_RGC STCLIDINWVLKLTLYGVSNFMSDQLDAEN-----I---------------K-VPE---Q gcy-9_Cele_RGC QNCLVDSNWTVKLTNFATEAVIFEKLDHNE-----LRP-----FINTDSESADDVS---D gcy-8_Cele_RGC WSCLIDRNWMIKLTDYGIADPLERWEKSQSISRDGL---------------T-SDD---D gcy-7_Cele_RGC KCCLIDDRWQVKISNYGLQDLRSPE----------------------------------- gcy-6_Cele_RGC KNCLLNDRWQLKITDFGLRIFRTHD----------------------------------- gcy-5_Cele_RGC ATCLVNDSWQVKLTDFGLGALLEEH----------------------------------- gcy-4_Cele_RGC ATCLVNDSWQVKLADFGLQFLQDEEE---------------------------------- gcy-3_Cele_RGC ATCLVNDSWQVKLAEFGFDQLLEEI----------------------------------- gcy-27_Cele_RGC ATCLIDINWVLKIALYGVTNFVCDNFDAEN-----I---------------T-MPD---R gcy-25_Cele_RGC SNCVVDSYWVVKLTDFGIKGILKERTNHKE-----L---------------APS-S---A gcy-23_Cele_RGC WSCLIDRNWMIKLTDYGIANPLERWEKLGLISTETL---------------K-EGD---D gcy-22_Cele_RGC STCLVDERWQVKVSFFGLSAIKQYE----------------------------------- gcy-21_Cele_RGC TNCLIDARWMVRLSSFGLRELRGEETWQQE------------------------------ gcy-20_Cele_RGC RCCLIDDRWQIKISGFGLKSVRTFE----------------------------------- gcy-2_Cele_RGC ATCLVNDSWQVKLAEYGMDNLVEEQ----------------------------------- gcy-19_Cele_RGC GTVLVNESWQAKLTDFGLGTLAEEK----------------------------------- gcy-18_Cele_RGC WCCLIDRNWMVKLSDYGIANPLERWEKQGAIEIAAA---------------K-DSD---D gcy-17_Cele_RGC RSCLIDDRWQVKISDFGLNEVRGMD----------------------------------- gcy-15_Cele_RGC TNCLIDARWMVRLSSFGLRELRGEETWQQE------------------------------ gcy-14_Cele_RGC RCCLIDDRWQIKISGYGLKSVRTFE----------------------------------- gcy-13_Cele_RGC ECCYINDRWQVKIGSYGLSFMQGVE----------------------------------- gcy-12_Cele_RGC TNCLITSRWTLQIADFGLRELREGIMYDSS------------------------------ gcy-11_Cele_RGC SNCIVDAYWRIKLSNYGMEQIRVEEPESKP-----DVFYDLVIF--SNKYN-SKTK---N gcy-1_Cele_RGC ATCLVNDSWQVKLAEYGMDNLVEEQ----------------------------------- daf-11_Cele_RGC HNCMLDSHWIVKLSGFGVNRLLVKWKTSGQ-----I---------------F--TE---- C04H5.4_Cele_RGC WSVLIDKNWMLKLTDYAVCDPLKRWEKHGRIN---C---------------K-VDN---E CYGF_Hsap_RGC RNCVVDGRFVLKVTDYGFNDILEMLRLS-E------------------------------ ANPb_Hsap_RGC SNCVVDSRFVLKITDYGLASFRSTAEPD-D------------------------------ ANPa_Hsap_RGC SNCVVDGRFVLKITDYGLESFRDLD-PE-Q------------------------------ CYGD_Hsap_RGC RNCIVDGRFVLKITDHGHGRLLEAQKVL-P------------------------------ T01A4.1_Cele_RGC SNCVVDSRFVLKVTDFGLHRLHCLEEINLE-------------------------E---I Npr1_Spur_RGC SNCVVDSRFVLKITDFGLTSFREPD-PS-S------------------------------ Npr2_Spur_RGC SNCVVDSRFVLKLTDYGLTKFRDTDSNE-R------------------------------ Gcy3_Spur_RGC SNLVVDSRWVLKITDFGLHQFRSGSRPPE------------------------------I Npr3_Spur_RGC SNCVVDGRFVLKITDFGIPSFRNSNKYE-------------------------------- Npr4_Spur_RGC SNCVVDDRWVVKIADYGLTTFRNQEGSQ-S-------------------------N---A Gcy1_Spur_RGC SNCVVDNRWVLQITDYGLNEFKKGQKQD-V-------------------------D---L Gcy2_Spur_RGC SNCVVDSRWVLKITDFGLVHFKVGQQPPD------------------------------M Npr5_Spur_RGC STCYVDSRWVLKISGFGLLSFNILKEDVMK-------------------------Q---- AqueK220_Aque_RGC NNCVIDQHWNLKLT---------------------------------------------- AqueK221_Aque_RGC VTCVIGNLWKLKLTDY-------------------------------------------- AqueK222_Aque_RGC TNCVIDDRWVVKITDYG------------------------------------------- : :: HSER_Hsap_RGC --------PKKDLWTAPEHLR----------QAN-----------------ISQKGDVYS CG10738_Dmel_RGC QHMS--AKCLKLLYRAPELLR----------QGPS------------SLVMGTQRGDAYS CG9783_Dmel_RGC R--T--RSAKELLWTAPELLR----------NMKLH----QHHHQHGRIQLGTQLGDVYS Gyc32E_Dmel_RGC S--E--LELKRALCMAPELLR----------DAYR-------------PGRGSQKGDVYS Gyc76C_Dmel_RGC -GEH--QHYRNQLWRAPELLR----------NHI----------------HGSQKGDVYA CG4224_Dmel_RGC N-SH--AYWSKLLWTAPELLR----------VEHN------------RPPEGTQKGDVYA CG3216_Dmel_RGC D--Q--NYYLKLLWIAPELLP----------LTTIP-----------GCCPATQRGDVYS KSGC_Mmus_RGC Q-EA--TDHSELYWTAPELLR----------LRES-------------PCSGTPQGDVYS HSER_Mmus_RGC --------PKKDLWTAPEHLR----------QAT-----------------ISQKGDVYS CYGX_Mmus_RGC P--Q--PAPEELLWTAPELLR----------GPG----------------KATFKGDVFS CYGF_Mmus_RGC E--E--PSEEELLWTAPELLR----------APGGI-------------RLGSFAGDVYS CYGD_Mmus_RGC E--P--PSAEDQLWTAPELLR----------DPSLE-------------RRGTLAGDVFS ANPb_Mmus_RGC S-H---ALYAKKLWTAPELLS----------GNP-------------LPTTGMQKADVYS ANPa_Mmus_RGC G-H---TLFAKKLWTAPELLR----------MAS-------------PPARGSQAGDVYS odr-1_Cele_RGC AAHM--ITYPQYVCFPPEHIR----------EYDDSGK--Q----PPRVVRGSPKGDIYC gcy-9_Cele_RGC PTKD--FARKKYLQQAPEIIR----------EIVTTKT----------IPEGSQSADIYA gcy-8_Cele_RGC KSQA--TQATSILYESPEMLK----------NREKNRVRRVDQDWMRQTQTRRQLGDVYA gcy-7_Cele_RGC ---M--YEKKDLLWSAPELLR----------AEDI---------------KGSKEGDVYS gcy-6_Cele_RGC ---Q--YNKSDRLWTSPELLR----------TDDI---------------LGSREGDIYS gcy-5_Cele_RGC ---T--PSKKRLLWAAPEVLR----------GSLT-------------IHQMDPSADVYS gcy-4_Cele_RGC ---K--PFKKNMLWAAPEVIR----------GSLS-------------IEQMDSSADIYS gcy-3_Cele_RGC ---T--PTKRRLLWAAPEVLR----------GSLT-------------VSQMDPSADVFS gcy-27_Cele_RGC SDYT--ISYAQYVCFPPEHIR----------EYDATGK--L----PTRFVRGSKQGDIYC gcy-25_Cele_RGC FDVD--AIHYKYLQLAPEHIS----------AILEKLE----------EPRGTVEGDIYQ gcy-23_Cele_RGC KSGS--AQKTSLLYQPPEMLK----------NKESNRTRRMDQSWVKQSQARRQMGDIYA gcy-22_Cele_RGC ---V--KEQRDFLHTAPEHIR----------DTNL---------------PITKEMDIYS gcy-21_Cele_RGC -DDV--QEGKDQLWTSPELLR----------WSTGLSQ---------CGVLLVQKSDVYS gcy-20_Cele_RGC ---N--PKKEDLLWASPEYLR----------NEDQ---------------ERLPEGDIYS gcy-2_Cele_RGC ---T--PPKKRLLWVAPEVLR----------GSLS-------------VSQMEPSADIYS gcy-19_Cele_RGC ---K--PMKRRQLWMAPEVIR----------GTLL-------------PHQIEKSADIYS gcy-18_Cele_RGC KSQA--SQATSIIYMAPELLK----------NRETNKRRGMDQSWVKQSMLRRQAGDIYS gcy-17_Cele_RGC ---K--LSTENMLWWAPEVLR----------GLE----------------QRSKEADIYS gcy-15_Cele_RGC -DDV--QEGKDQLWTSPELLR----------WSTGLSQ---------CGVLLVQKSDVYS gcy-14_Cele_RGC ---N--PKKEDLLWTPPENLR----------NENE---------------ERLPEGDIYS gcy-13_Cele_RGC ---K--RTEDGLLHTAPEVLR----------EGLT---------------SGTQAGDVYS gcy-12_Cele_RGC ---Y--NIWENFLWTAPEAMT----------INGSL-A---------ISNPPTPKADAYS gcy-11_Cele_RGC P-IK--KFSTDLLWFAPEIIR----------RYAVKHD---------LSKLELAKADIYS gcy-1_Cele_RGC ---T--PPKKRLLWVAPEVLR----------GSLS-------------VSQMEPSADIYS daf-11_Cele_RGC -DHTPVIKSEELHYFDPAMKKIWKNYADRNERALITPQ-------------FGKKCDMYS C04H5.4_Cele_RGC AEKQ--WQKMASLYVPPEIRT----------ANEKNRLKRMDQKWQGQTILKRQQSDIYA CYGF_Hsap_RGC E--E--SSMEELLWTAPELLR----------APRGS-------------RLGSFAGDVYS ANPb_Hsap_RGC S-H---ALYAKKLWTAPELLS----------GNP-------------LPTTGMQKADVYS ANPa_Hsap_RGC G-H---TVYAKKLWTAPELLR----------MAS-------------PPVRGSQAGDVYS CYGD_Hsap_RGC E--P--PRAEDQLWTAPELLR----------DPALE-------------RRGTLAGDVFS T01A4.1_Cele_RGC G-EH--AYYKKMLWTAPELLR----------DSN-------------APPMGTQKGDIYS Npr1_Spur_RGC --S---TYFAGRLWTAPELLR----------LPE-------------IPSGGTQKGDVYS Npr2_Spur_RGC Q-TS--KNEQKMLWQAPETLR----------SAN-------------Q--QPTQKGDIYS Gcy3_Spur_RGC -GEH--AKYEKLLWRAPELLR----------DPAP-------------RPEGTQKGDMYS Npr3_Spur_RGC ---D---NNYKLLWRAPERLR----------DPF-------------S--PPSKEGDLYA Npr4_Spur_RGC G-GY--RSKAMQVYLPPENRS----------NTY---------------TLVTQATDVYS Gcy1_Spur_RGC -GDH--AKLARQLWTSPEHLR----------QEGS------------MPTAGSPQGDIYS Gcy2_Spur_RGC -GEH--AYYQDLLWKAPEVWE----------------------------PQGTQKGDVYS Npr5_Spur_RGC KDPE--VKFSKMLWTAPEHLR----------GEML-------------PSKGSQKGDVYS AqueK220_Aque_RGC ------------------------------------------------------------ AqueK221_Aque_RGC ------------------------------------------------------------ AqueK222_Aque_RGC ------------------------------------------------------------ HSER_Hsap_RGC YGIIAQEIILRKETFYTLS--CR-D-------------RN-EKIFR--V-ENS----NGM CG10738_Dmel_RGC FGILLYEMHVRRGPFGETG----LT-------------PM-QCLQK--V-LQPQD---YL CG9783_Dmel_RGC FGIIMQEVVVRGEPYCMLS----LS-------------PE-EIIVK--I-KK-----P-P Gyc32E_Dmel_RGC FGILLYEMIGRKGPWGDTA----YS-------------KE-EIIQF--V-KCPEM--LQH Gyc76C_Dmel_RGC FAIIMYEIFSRKGPFGQIN----FE-------------PK-EIVDY--V-KKLPL--KGE CG4224_Dmel_RGC FGIIVHEITTRQGPFYLGRCAYEKS-------------PQ-EIIEL--V-KGYNP-HRMQ CG3216_Dmel_RGC FGIILEEIVNRGGPYQEAR--QQMD-------------VH-TILHK--V-RQ-------C KSGC_Mmus_RGC FAILLRDLIHQQAHGPFED--LEAA-------------PE-EIISR--I-KDPR----AP HSER_Mmus_RGC FAIIAQEIILRKETFYTLS--CR-D-------------HN-EKIFR--V-EN-----SYG CYGX_Mmus_RGC LAIILQEVLTRDPPYCSWG----LS-------------AE-EIIRK--V-AS-----P-P CYGF_Mmus_RGC FAIIMQEVMVRGAPFCMMD----LP-------------AK-EIIDR--L-KM-----P-P CYGD_Mmus_RGC LAIIMQEVVCRSTPYAMLE----LT-------------PE-EVIQR--V-RS-----P-P ANPb_Mmus_RGC FAIILQEIALRSGPFYLEG--LDLS-------------PK-EIVQK--V-RN-----GQR ANPa_Mmus_RGC FGIILQEIALRSGVFYVEG--LDLS-------------PK-EIIER--V-TR-----GEQ odr-1_Cele_RGC VGMIFYMMVEREDPYHLIH--SVER-------------PNATLIKQ--I-LN-----E-- gcy-9_Cele_RGC LGMVLYQILFRVEPFHERN--KSIN----------------KLMET--L-AMAN---DDD gcy-8_Cele_RGC FGLVMYEIIFRALPFPEG---TN---------------QS-ELVEW--L-RD------GS gcy-7_Cele_RGC LGIICAELITRKGVFNMED--RKED-------------PE-EIIYL--L-KK-----GGL gcy-6_Cele_RGC FGIISAELITRSSVFDLEN--RKED-------------AE-EIIYM--L-KK-----GGL gcy-5_Cele_RGC FAIIASEILTKREAWDISN--RKEG-------------AD-EILYM--V-KK-----GGN gcy-4_Cele_RGC FAIVASEILTKREAWDLSR--R----------------KE-EIKYA--V-KK-----GGQ gcy-3_Cele_RGC FAIIASEILTRKEAWDLKE--RKEG-------------YD-EIIYR--V-KK-----GGS gcy-27_Cele_RGC VGMIFYMMIEREDPYRLIH--SVER-------------PGSGLMME--I-LD-----H-- gcy-25_Cele_RGC LAMCIYQILFYMRPFAERQ--ESIKVY----SGEIFLKLP-ELAHL--L-S--S---QST gcy-23_Cele_RGC FGMVMHEILFRALPFPNG---TN---------------VS-EVMDY--I-RD------GT gcy-22_Cele_RGC FAIICSELITKKSAWDLEN--ETFD-------------IE-ELVYK--I-KK-----GGR gcy-21_Cele_RGC LAIVLYELFGRLGPWGDEP--ME---------------PR-EIVSL--V-KRE--ALAGK gcy-20_Cele_RGC FGIICAEILTRSSAFDLEN--RKEK-------------PD-VIIYQ--V-KK-----GGH gcy-2_Cele_RGC FAIIASEILTKKEAWDILD--RKED----------------------------------- gcy-19_Cele_RGC LAVIASEVLTRKEAWNMAE--RKDT-------------VD-EIVYR--I-KK-----GGP gcy-18_Cele_RGC FGMVMYEILFRSLPFRDN---TN---------------IS-ELVDY--L-AD------GS gcy-17_Cele_RGC FGIICSEVITRSSAFDLEN--RKEK-------------PE-EIIYQ--L-KK-----GGF gcy-15_Cele_RGC LAIVLYELFGRLGPWGDEP--ME---------------PR-EIVSL--V-KRE--ALAGK gcy-14_Cele_RGC FGIICSEILTRSSAFDLEN--RKEK-------------PD-VIIYQ--V-KK-----GGH gcy-13_Cele_RGC FSIVCSELVGHSSAWNLEN--RKEE-------------AD-EIIFM--V-KR-----GGR gcy-12_Cele_RGC FGIIFHEIFTREGPYKIYV--QRGDVNGEAAPKKDSVECR-ALVEK--TVRRV----YSD gcy-11_Cele_RGC LAIVLYEIYGRQGPFGDDL--LD---------------SD-EIIEQ--L-KFP----DGG gcy-1_Cele_RGC FAIIASEILTKKEAWDILD--RKED-------------CE-EIVYN--V-KK-----GGL daf-11_Cele_RGC FGVILHEIILKKKFVEQLF--DS---------------PR-EEDDSVLI-DDENDAIASR C04H5.4_Cele_RGC FGVIIYEILFRSLPYDEK---VD---------------LT-ELAQK--A-AE------GD CYGF_Hsap_RGC FAIIMQEVMVRGTPFCMMD----LP-------------AQ-EIINR--L-KK-----P-P ANPb_Hsap_RGC FGIILQEIALRSGPFYLEG--LDLS-------------PK-EIVQK--V-RN-----GQR ANPa_Hsap_RGC FGIILQEIALRSGVFHVEG--LDLS-------------PK-EIIER--V-TR-----GEQ CYGD_Hsap_RGC LAIIMQEVVCRSAPYAMLE----LT-------------PE-EVVQR--V-RS-----P-P T01A4.1_Cele_RGC FAIILHEMMFRKGVFALEN--EDLS-------------PN-EIVQR--V-RKPVS--EDQ Npr1_Spur_RGC FGIILQEIMYREGVFYIKD--VDLM-------------PE-EIVKK--V-AN-----GYK Npr2_Spur_RGC VGIIMQEIVTRARPFEEER--SSME-------------ID-EIVKK--L-TE-----TSS Gcy3_Spur_RGC LGIILYEMATRQGPYG-------------------------------------------- Npr3_Spur_RGC LGIIMLEIGTRCGPFDEER--KVMD-------------TN-GILEI--L-KST----SSQ Npr4_Spur_RGC YGVILVEIASRNEVIPEDD--YPL---------------D----------------EAWR Gcy1_Spur_RGC FAIILTELYSRQEPFHENE----MD-------------LA-DIIAR--V-KIG-----EV Gcy2_Spur_RGC FGIILYEIAHRQGPFGNCE----LS-------------PK-EIYEK--V-KTLG----ET Npr5_Spur_RGC FAIILQEIVTRSHPFYLSG--YT---------------SR-EIIRR--V-IR-----RDE AqueK220_Aque_RGC ------------------------------------------------------------ AqueK221_Aque_RGC ------------------------------------------------------------ AqueK222_Aque_RGC ------------------------------------------------------------ HSER_Hsap_RGC KPFRPDL-FLET-----A----EEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAK-IFG CG10738_Dmel_RGC NPYRPSL-QPLE-----------TAFDCVSECLRECWAERPEDRPD-------------- CG9783_Dmel_RGC PLIRPSV-SKG------------AAPPEAINIMRQCWAEQPDMRPDFNSVYE-------- Gyc32E_Dmel_RGC GVFRPAL-THTH----------LDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHL------ Gyc76C_Dmel_RGC DPFRPEV-ESIIE----A----ESCPDYVLACIRDCWAEDPEERPE-------------- CG4224_Dmel_RGC KPFRPEL-EPN-----------GDTKADINGIIRRCWAEDPAERPDFNTLKS-------- CG3216_Dmel_RGC NGFRPLI-RER------------ECPPDLLELMEKCWADNQEERPTFSTIRSNIRT-IMK KSGC_Mmus_RGC VPLRPSL-LED------------KGDGRIVALVRECWDESPELRPIFPSIKKT------- HSER_Mmus_RGC KPFRPDL-FLET-----A----DEKELEVYLLVKSCWEEDPEKRPDFKKIESTLAK-IFG CYGX_Mmus_RGC PLCRPLV-SPD------------QGPLECIQLMQLCWEEAPDDRPSLDQIYTQF------ CYGF_Mmus_RGC PVYRPVV-SPE------------YAPAECLQLMKQCWAEASEQRPTFDEIFNQF------ CYGD_Mmus_RGC PLCRPLV-SMD------------QAPMECIQLMTQCWAEHPELRPSMDLTFD-L------ ANPb_Mmus_RGC PYFRPSI-DRT------------QLNEELVLLMERCWAQDPTERPDFGQIKGFI------ ANPa_Mmus_RGC PPFRPSM-DLQ------------SHLEELGQLMQRCWAEDPQERPPFQQIRLAL------ odr-1_Cele_RGC -NHMPRI-TDDYR----Q-------ENMLLEMCKECWDRNPDKRPTIKKLIES------- gcy-9_Cele_RGC QLIRPTF-PSSNT----G----EGYNLQLLSCIEACWLEIPEMRPPIKKVRTMVNANLKS gcy-8_Cele_RGC KVVKPTI-PQNKV----L-------NMDLSALIQDCWNTTPEMRPSLRRIKLNV------ gcy-7_Cele_RGC KSPRPDL-EYDHT---------IEINPALLHLVRDCFTERPSERPSIETVRSQLRG-MNS gcy-6_Cele_RGC QSPRPSL-EHDES---------IEINPALLHLVRDCWTERPSERPDIKQVASQLRS-MNT gcy-5_Cele_RGC RTIRPEL-ILD-----------AEVSPRLTTLVKDCWSEQPEDRPKAEQICKLLSE-MTP gcy-4_Cele_RGC FVLRPDL-HID-----------IEVNQTLLALVKDCWCENPEERPSAENVCKVLFD-MTP gcy-3_Cele_RGC FPIRPDI-ITDV----------PDVNPTLIALVKDCWAEAPEDRPTAENICEQLRD-LMP gcy-27_Cele_RGC -NLMPFI-SNNET----Q-------EDTLLDKCKECWNRDPEKRPTIENLRNA------- gcy-25_Cele_RGC APLHPKV-PE-------G----NSFTMRLLSIIQQCWLYKPAARPALIKITDAVNREFGQ gcy-23_Cele_RGC KTFRPTV-HDRTQ----I-------HPDLVALLLDCWNENPEVRPSIRRVRLNT------ gcy-22_Cele_RGC SPPRPSL-ETED-----------EHNGSMSLLVRDCWNENPDQRPTSEQIKTLMKS-MNH gcy-21_Cele_RGC KPFRPDM-AVLKE----S-------PRIVQETVVAAWTEDPLNRPSLHQIKR-------- gcy-20_Cele_RGC NPTRPSL-DTGET---------VVINPALLHLVRDCWTERPSERPSIEQVRSHLNG-MKD gcy-2_Cele_RGC -------------------------CEALIALVKDCWAEVPEDRPTAENICSQMKG-LVS gcy-19_Cele_RGC NAPRPEL-DMDG----------VEINHNLLILIRDCWSEEPADRPSADVICNLLKN-MMP gcy-18_Cele_RGC KTVSPEI-QNQMG----L-------HPDLNALLRDCWSENPEIRPSIRRVRLN------- gcy-17_Cele_RGC NAIRPSL-LTDEA---------LEINPALVHLIRDCWTEKPSERPPIDQVRSLLRG-MND gcy-15_Cele_RGC KPFRPDM-AVLKE----S-------PRIVQETVVAAWTEDPLNRPSLHQIKR-------- gcy-14_Cele_RGC NPMRPSL-DTGET---------VEINPALLHLIRDCWTERPSERPSIEQVRGHLNG-MRD gcy-13_Cele_RGC TPFRPSL-DDVD----------DDINPAMLHLIRDCWDEDPKQRPNIDMVNKLMKN-MNS gcy-12_Cele_RGC PYFRPDT-SD-------L-----EVQNYVKEVMAACWHHDPYQRPEFKTIKNKLK----- gcy-11_Cele_RGC ALTRPDI-HL-------I----TKAPYPLASVVEKCWVEDPASRPSIQKVREL------- gcy-1_Cele_RGC FPIRPEI-ITDI----------HDVNPALIALVKDCWAEVPEDRPTAENICSQMKG-LVS daf-11_Cele_RGC FP-LPIIIPEGIE----M-------HNDLIKMLENCFGS---VRPDIALA-R-------- C04H5.4_Cele_RGC KIQKPSI-QRNKK----L-------NPDLIALLQGIVF-------------VSL------ CYGF_Hsap_RGC PVYRPVV-PPE------------HAPPECLQLMKQCWAEAAEQRPTFDEIFNQF------ ANPb_Hsap_RGC PYFRPSI-DRT------------QLNEELVLLMERCWAQDPAERPDFGQIKGFI------ ANPa_Hsap_RGC PPFRPSL-ALQ------------SHLEELGLLMQRCWAEDPQERPPFQQIRLTL------ CYGD_Hsap_RGC PLCRPLV-SMD------------QAPVECILLMKQCWAEQPELRPSMDHTFD-L------ T01A4.1_Cele_RGC EPLRPWV-SETGEGEG-D----DALNDTLLSLMVACWSEDPHERPEVSSVRKAVR----- Npr1_Spur_RGC PAFRPTI-DRV------------TCSQEMMTLITNCWKEDSTIRPDYSQLRGT------- Npr2_Spur_RGC PPFRPEI-DPQ------------LCTDEIRSIIQACWEEMPENRPATTDLLSS------- Gcy3_Spur_RGC ------------------------------------------------------------ Npr3_Spur_RGC PPFRPSV-PEA------------VWNPVIKDLMKRCWAENPGDRPTASALQTAL------ Npr4_Spur_RGC -PPLPDL-EIGDTTDDER----CPCPADYLSLIERCWNINPAQRPHFSQIRQT------- Gcy1_Spur_RGC PPYRPIL-NAVN----------AAAPDCVLSAIRACWPEDPDDRPNIMAVRTMLAP-L-- Gcy2_Spur_RGC IPLRPNV-MEIE-----------NGHECLLTVMQECWVEDPEARPDFKTIAN-------- Npr5_Spur_RGC PPCRPKI-NEDEF----ETSDMATIFTAIYELMKVCWEELPEDRPDFTAIRA-------- AqueK220_Aque_RGC ------------------------------------------------------------ AqueK221_Aque_RGC ------------------------------------------------------------ AqueK222_Aque_RGC ------------------------------------------------------------ HSER_Hsap_RGC LFHD-------QKNES-YM CG10738_Dmel_RGC ------------------F CG9783_Dmel_RGC -----------------RF Gyc32E_Dmel_RGC -----------------KE Gyc76C_Dmel_RGC ------------------F CG4224_Dmel_RGC ------------------M CG3216_Dmel_RGC GFCE-------NLMDD-LL KSGC_Mmus_RGC ------------------L HSER_Mmus_RGC LFHD-------QKNES-YM CYGX_Mmus_RGC -----------------KS CYGF_Mmus_RGC -----------------KT CYGD_Mmus_RGC -----------------FK ANPb_Mmus_RGC -----------------RR ANPa_Mmus_RGC -----------------RK odr-1_Cele_RGC ---------------I-ST gcy-9_Cele_RGC TGKGSLVDQMMKMMEE-YT gcy-8_Cele_RGC --------------ET-YL gcy-7_Cele_RGC SR-------NDNLMDH-VF gcy-6_Cele_RGC NR-------NDNLMDH-VF gcy-5_Cele_RGC RG-------NTNLMDH-VF gcy-4_Cele_RGC NT-------EDNLMDHVFS gcy-3_Cele_RGC KT-------KSNLMDH-VF gcy-27_Cele_RGC ---------------I-AI gcy-25_Cele_RGC DVKGTLIDQMI-EMID-EY gcy-23_Cele_RGC --------------EN-YL gcy-22_Cele_RGC NR-------SSNLMDH-VF gcy-21_Cele_RGC -----------------KL gcy-20_Cele_RGC GR-------KTNLMDH-VF gcy-2_Cele_RGC KQ-------KTNLMDH-VF gcy-19_Cele_RGC -K-------KGNLMDH-VF gcy-18_Cele_RGC ---------------T-EM gcy-17_Cele_RGC GK-------KGNLMDH-VF gcy-15_Cele_RGC -----------------KL gcy-14_Cele_RGC GR-------KSNLMDH-VF gcy-13_Cele_RGC GRSG-----SANLMDHVFS gcy-12_Cele_RGC ---------------P-LF gcy-11_Cele_RGC ------------------L gcy-1_Cele_RGC KQ-------KTNLMDH-VF daf-11_Cele_RGC -----------------KI C04H5.4_Cele_RGC --------------AA-SL CYGF_Hsap_RGC -----------------KT ANPb_Hsap_RGC -----------------RR ANPa_Hsap_RGC -----------------RK CYGD_Hsap_RGC -----------------FK T01A4.1_Cele_RGC -----------------SL Npr1_Spur_RGC ------------------M Npr2_Spur_RGC ------------------M Gcy3_Spur_RGC ------------------K Npr3_Spur_RGC ------------------K Npr4_Spur_RGC ------------------L Gcy1_Spur_RGC -------------QKG-LK Gcy2_Spur_RGC -----------------KL Npr5_Spur_RGC -----------------KL AqueK220_Aque_RGC ------------------D AqueK221_Aque_RGC ------------------G AqueK222_Aque_RGC ------------------I