CLUSTAL W (1.83) multiple sequence alignment Cdk4_Dmel YQELNIIGEGAYGTVYRARDVIT-GNIVALKKVRISLN---ENGVPMSTLREISLLKQLN CDK6_Mmus YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTS---EEGMPLSTIREVAVLRHLE CDK4_Mmus YEPVAEIGVGAYGTVYKARDPHS-GHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLE cdk-4_Cele --LFQALGKGAYGNVYRVRSLHD-GKDYALKQIMISSK---NEGIPQSVLREITVMKHLA CDK4_Hsap YEPVAEIGVGAYGTVYKARDPHS-GHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE CDK6_Hsap YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTG---EEGMPLSTIREVAVLRHLE CDK4_Spur YVQAAEIGSGAYGIVYKARDTET-GHFVALKSVRIPIG---EEGMPVSTIREISLLRHLC :* **** *::.*. *. *** : : *:* *.:**::::::* Cdk4_Dmel ASNHANIVKLYEVCQFLERDG-QLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRE CDK6_Mmus TFEHPNVVRLFDVCTVSRTDR-ETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ CDK4_Mmus AFEHPNVVRLMDVCATSRTDR-DIKVTLVFEHIDQDLRTYLDKAPPPGLPVETIKDLMRQ cdk-4_Cele RKAHPNIISLKSVFHQLDPVRAILKINMIMERCDWDLHTFLRNIP-RGVPEQQAKHVTAQ CDK4_Hsap AFEHPNVVRLMDVCATSRTDR-EIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ CDK6_Hsap TFEHPNVVRLFDVCTVSRTDR-ETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ CDK4_Spur QLDHPNIVKLLDVCDVMDVGRSEMMLTLVFELVDQDLAQYLEKCPPPGLSPCTIKFLMHQ *.*:: * .* : :::* : ** : . * *:. : : : Cdk4_Dmel LLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKLTSVVVTLWYRAP CDK6_Mmus LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP CDK4_Mmus FLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSYQMALTPVVVTLWYRAP cdk-4_Cele IVRALDFLHTHSIIHRDLKPQNILLNRDQTVKLADFGLSKEYSNTTAFTTLVVTLWYRSP CDK4_Hsap FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAP CDK6_Hsap LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP CDK4_Spur LLSGVEYLHSHRVTHRDLKPQNILVASDKKLKLTDFGLSRVYSFQMALTPVVVTMWYRAP :: .:::**:: : ******:*:*: :*::****:: *. :*.:***:***:* Cdk4_Dmel EVLLAQPYNSTVDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTIS CDK6_Mmus EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDIIGLPGEEDWPRDVA CDK4_Mmus EVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVS cdk-4_Cele EVLLQSYYNSTVDMWALGCIVSEIYCRQPLFVGQNEAEQLTDIFKKMGTPVGKDWPSESV CDK4_Hsap EVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS CDK6_Hsap EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA CDK4_Spur EVLLQASYATPVDMWSVGCIFAELYRRRPLFRGQSDKDQLHKIFEVIGLPPEDQWP-DVA **** * :.**:*: .**. *:: *:.** * .: :** *:. * * .:** Cdk4_Dmel VALEHFPQRHPKRPKDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYF CDK6_Mmus LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYGALNHPYF CDK4_Mmus LPRGAFAPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL cdk-4_Cele IARDSFPQYRPTNLKDLSPQMSKQAIEFVQQCLRYDHSKRLSARGALSHPFL CDK4_Hsap LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL CDK6_Hsap LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF CDK4_Spur LPWSSFRQTGQRSFLDLVQEICNQGLDLLERMLCFNPDHRMTAEQGLLHGFF :. * .. .: : . ::: . * :: * :* * * ::