CLUSTAL W (1.83) multiple sequence alignment Cdk8_Dmel ---EGCKVGRGTYGHVYKAKWKET--S-DGKEYALKQ----------IDGTGLSMSACRE CDK8_Mmus FEYEGCKVGRGTYGHVYKAKRKDG--K-DDKDYALKQ----------IEGTGISMSACRE CDK19_Mmus FEYEGCKVGRGTYGHVYKARRKDG--K-DEKEYALKQ----------IEGTGISMSACRE F39H11.3_Cele FENSK-EIGRGTYGLVYKAVPKKQNGQFPNKEYALKM----------IEGQGFSMSACRE SSN3_Scer YEVIG-YIAAGTYGKVYKAKRQIIKKP-LTVFYAIKKFKTEKDGVEQLHYTGISQSACRE CDK19_Hsap FEYEGCKVGRGTYGHVYKARRKDG--K-DEKEYALKQ----------IEGTGISMSACRE CDK8_Hsap FEYEGCKVGRGTYGHVYKAKRKDG--K-DDKDYALKQ----------IEGTGISMSACRE Cdk8_Ddis FSY---EIGSGTYGMVYKADDKKRPN----NKVAVKKFRS------TKEGEGLSLTAYRE CDK8_Spur ------KVGRGTYGHVYKATTKKE----PKKEYALKQ----------IEGTGISMSACRE CC1G_07887_Ccin YAILG-FISSGTYGRVYKAQSINGGE-----LLAIKKFKPDKEG-DVVTYTGISQSAIRE AqueK099_Aque MD-SGF---------ID------------------------------------ALSQK-- CDK8_Smoe YELLG-KIGEGTYGLVYLAKSKLVSN--RGVKIAIKKFKQ------SKEGDGVSPTAIRE : : : Cdk8_Dmel IALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKK-QVVVPR CDK8_Mmus IALLRELKHPNVISLLKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKK-PVQLPR CDK19_Mmus IALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKK-PMQLPR F39H11.3_Cele IALFRELRHPNLICLQRVFLTN-EKKVWLLLDYAEHDLWHVIKHHRTAKSKKV-PIMVPR SSN3_Scer MALCRELHNKHLTTLVEIFLE--RKCVHMVYEYAEHDLLQIIHFHSHPE-----KRMIPP CDK19_Hsap IALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKK-PMQLPR CDK8_Hsap IALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKK-PVQLPR Cdk8_Ddis IGLLKELSNENIVKLLDVCLNPKDKLLYLIFDYAEFDLFGIIKYHRENG------SHFSD CDK8_Spur VALLRELRHPNVICLRRVFLSHSDRKVYLLCDFSEHDLWHIIKYHRANKASKKGPTSVPP CC1G_07887_Ccin IALNREINHENVVALREVILE--DKSIYMVFEYAEHDFLQVIHHYYQTI-----RTSIPT AqueK099_Aque -----------------------------------REKVEDLKYHRAVKGGKKPQVQVPK CDK8_Smoe IMLLRECMHENVVKLVDVHINHADMSLYLAFEYAEHDLYEIIRHHREKL-----LFQINP : ::.: . Cdk8_Dmel GMVKSLLYQILDGIHYLHSNWVLHRDLKPANILV-------------------------- CDK8_Mmus GMVKSLLYQILDGIHYLHANWVLHRDLKPANILV-------------------------- CDK19_Mmus SMVKSLLYQILDGIHYLHANWVLHRDLKPANILV-------------------------- F39H11.3_Cele NMVKNILFQILSGMHYLHSNWVLHRDLKPANILL-------------------------- SSN3_Scer RMVRSIMWQLLDGVSYLHQNWVLHRDLKPANIMV-------------------------- CDK19_Hsap SMVKSLLYQILDGIHYLHANWVLHRDLKPANILV-------------------------- CDK8_Hsap GMVKSLLYQILDGIHYLHANWVLHRDLKPANILV-------------------------- Cdk8_Ddis ATIKSLIWQVLNGIHYLHSNWVIHRDLKPSNILV-------------------------- CDK8_Spur VMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGFARLFNSPLK CC1G_07887_Ccin AVLKSLIYQLFNGLIYLHASHILHRDLKPANILI-------------------------- AqueK099_Aque TMVKSLMYQILSGIHYLHSNWVLHRDLKPANILV-------------------------- CDK8_Smoe YTVKSLLWQILNGINYLHSNWIIHRDLKPSNILV-------------------------- ::.:::*::.*: *** . ::******:**:: Cdk8_Dmel ------------------------------------------------------------ CDK8_Mmus ------------------------------------------------------------ CDK19_Mmus ------------------------------------------------------------ F39H11.3_Cele ------------------------------------------------------------ SSN3_Scer ------------------------------------------------------------ CDK19_Hsap ------------------------------------------------------------ CDK8_Hsap ------------------------------------------------------------ Cdk8_Ddis ------------------------------------------------------------ CDK8_Spur PLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSN CC1G_07887_Ccin ------------------------------------------------------------ AqueK099_Aque ------------------------------------------------------------ CDK8_Smoe ------------------------------------------------------------ Cdk8_Dmel -------------------------------------------------------MG--- CDK8_Mmus -------------------------------------------------------MG--- CDK19_Mmus -------------------------------------------------------MG--- F39H11.3_Cele -------------------------------------------------------MG--- SSN3_Scer -------------------------------------------------------TI--- CDK19_Hsap -------------------------------------------------------MG--- CDK8_Hsap -------------------------------------------------------MG--- Cdk8_Ddis -------------------------------------------------------MG--- CDK8_Spur PYHHDQLDRIFNVMGFPQVPPVMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMG--- CC1G_07887_Ccin -------------------------------------------------------TS--- AqueK099_Aque -------------------------------------------------------MG--- CDK8_Smoe -------------------------------------------------------MGVSG Cdk8_Dmel DGN--ERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWA CDK8_Mmus EGP--ERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWA CDK19_Mmus EGP--ERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWA F39H11.3_Cele DGPPDMRGRVKIADLGFSRIYANPLKPMAELDPVVVTFWYRAPELLLGAKHYTKAIDVWA SSN3_Scer D------GCVKIGDLGLARKFHNMLQTLYTGDKVVVTIWYRAPELLLGARHYTPAVDLWS CDK19_Hsap EGP--ERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWA CDK8_Hsap EGP--ERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWA Cdk8_Ddis EGK--ECGTVKIGDFGLARIFQSPLKPLNE-NGVVVTIWYRSPELLLGSKHYTRAVDIWA CDK8_Spur EGS--ERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWA CC1G_07887_Ccin Q------GVVKIGDLGLARLCYEPLQPLFAGDKVVVTIWYRAPELLMGAKHYNKAIDCWA AqueK099_Aque DGP--ERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGAKHYTKAIDIWA CDK8_Smoe DGD--EQGLVKIGDFGLARIYQAPLKPLSD-NGVVVTIWYRAPELLLGAKHYTCAVDMWA : * ***.*:*::* *:.: : ****:***:****:*::**. *:* *: Cdk8_Dmel IGCIFAELLTSEPIFHCRQE--DIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHH CDK8_Mmus IGCIFAELLTSEPIFHCRQE--DIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHS CDK19_Mmus IGCIFAELLTSEPIFHCRQE--DIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYP F39H11.3_Cele IGCIFAELLTAEPLFFCKEE--DIKAQNPYHYDQVKRIFHLLGYPSDADWPDMKKMPDHQ SSN3_Scer VGCIFAELIGLQPIFKGEEAKLDSKKTVPFQVNQLQRILEVLGTPDQKIWPYLEKYPEYD CDK19_Hsap IGCIFAELLTSEPIFHCRQE--DIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYP CDK8_Hsap IGCIFAELLTSEPIFHCRQE--DIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHS Cdk8_Ddis IGCIFAELITTKPLFPGKEK--DPKIPSLFQDDQVEKIIRVLGKPTLDMWPDIKHLPEWK CDK8_Spur IGCIFAELLTSEPIFHCRQE--DIKTSNPYHHDQLDRIFNVMGFPQEKDWEDIKKMPEHG CC1G_07887_Ccin VGCVMAELASLRPIFKGEEAKLDSKKNVPFQRDQLIKIFEVLGTPDERDWPGVVDMPEYR AqueK099_Aque IGCIFAELLTFEPIFHCRQE--DVEASSPYHREQLERIFLVMGFPHDRDWDDMKHMPEYS CDK8_Smoe VGCIFAELLTLKPLFQGA-E--DKTGPNPFQLDQLDKIFKVLGHPTTERWPMLSNLPHWL :**::*** .*:* * :: :*: :*: ::* * * : . *. Cdk8_Dmel TLTKDFKRS-----TYSTCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRITSEQAMQD CDK8_Mmus TLMKDFRRN-----TYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQD CDK19_Mmus TLQKDFRRT-----TYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQD F39H11.3_Cele RLLSDARNEGTPIQTFPN-SLHRYFDKWKINSQSSPYRLLVKLLTVDPTKRVSCEEAMND SSN3_Scer QITKFP--------KYRD-NLATWYH-SAGGRDKHALSLLYHLLNYDPIKRIDAFNALEH CDK19_Hsap TLQKDFRRT-----TYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQD CDK8_Hsap TLMKDFRRN-----TYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQD Cdk8_Ddis RLSSM---E-----AFPN-SLAKC---VGIDENSQAYDLLSKMILYDPSKRITASEALDH CDK8_Spur NLMKDFRRS-----NYASCCLPKYMEKHKVPKDSKAFQLLSKLLTMDPTKRMTSEQAMED CC1G_07887_Ccin NMKLLD--------HFSN-RLSDWCH-T-RIRSPQGYDLLRQLFAYDPDNRLTAEQAIQH AqueK099_Aque TLMRDFGRQK---ANFANCASQKYMDKHNVKHDTSAFKLLTKFLVMDPNKRITSDQAMLD CDK8_Smoe ANRQLIQSR-----KYDNPGLHTV---VNLQPKGLAFDLLSRMLEYDPVKRITAAQALDH : . ** ::: ** :*: . :*: . Cdk8_Dmel QYF CDK8_Mmus PYF CDK19_Mmus PYF F39H11.3_Cele IYF SSN3_Scer KYF CDK19_Hsap PYF CDK8_Hsap PYF Cdk8_Ddis PYF CDK8_Spur QYF CC1G_07887_Ccin KWF AqueK099_Aque TYF CDK8_Smoe EYF :*