CLUSTAL W (1.83) multiple sequence alignment gish_Dmel FRVGKKIGCGNFGELRLGKNLY-----------------NNEHVAIKMEPMKSKAPQLHL Y106G6E.6_Cele FKVGKKIGCGNFGELRLGKNLY-----------------NNEHVAIKLEPMKSKAPQLHL YCK1_Scer YKIGKKIGEGSFGVLFEGTNMI-----------------NGVPVAIKFEPRKTEAPQLRD YCK2_Scer YKIGKKIGEGSFGVLFEGTNMI-----------------NGLPVAIKFEPRKTEAPQLKD YCK3_Scer YAVGPKIGEGSFGVIFEGENILHSCQAQTGSKRDSSIIMANEPVAIKFEPRHSDAPQLRD CK1g_Spur FRVGKKIGCGNFGELRLGKNLY-----------------NNEHVAIKLEPMRSRAPQLHL CK1g1_Mmus FRVGKKIGCGNFGELRLGKNLY-----------------TNEYVAIKLEPIKSRAPQLHL CK1g2_Mmus FRVGKKIGCGNFGELRLGKNLY-----------------TNEYVAIKLEPIKSRAPQLHL CK1g3_Mmus FRVGKKIGCGNFGELRLGKNLY-----------------TNEYVAIKLEPMKSRAPQLHL CK1g1_Hsap FRVGKKIGCGNFGELRLGKNLY-----------------TNEYVAIKLEPIKSRAPQLHL CK1g2_Hsap FRVGKKIGCGNFGELRLGKNLY-----------------TNEYVAIKLEPIKSRAPQLHL CK1g3_Hsap FRVGKKIGCGNFGELRLGKNLY-----------------TNEYVAIKLEPMKSRAPQLHL CC1G_07108_Ccin ------------------------------------------------------------ CC1G_01170_Ccin YRVGKKIGEGSFGVIFEGTNLL-----------------NSQTVAIKFEPRKAEAPQLRD AqueK090_Aque FRVGKKIGCGNFGELRLGKNLY-----------------NNEHVAIKLEPMKSRAPQLHL gish_Dmel EYRFYKLLGS-----------------------------HAEGVPEVYYFGPCGKYNALV Y106G6E.6_Cele EYRFYKLLGQ------------------------------AEGLPQVHYFGPCGKYNALV YCK1_Scer EYKTYKILNG------------------------------TPNIPYAYYFGQEGLHNILV YCK2_Scer EYRTYKILAG------------------------------TPGIPQEYYFGQEGLHNILV YCK3_Scer EFRAYRILNG------------------------------CVGIPHAYYFGQEGMHNILI CK1g_Spur EYRFYKMLGQ------------------------------SEGIPQVHYFGPCGKYNAMV CK1g1_Mmus EYRFYKQLGS-----------------------------AGEGLPQVYYFGPCGKYNAMV CK1g2_Mmus EYRFYKQLSTTGEADSGT-GPALLGQ--QWLRTPSMDVSFAEGVPQVYYFGPCGKYNAMV CK1g3_Mmus EYRFYKQLGS------------------------------GDGIPQVYYFGPCGKYNAMV CK1g1_Hsap EYRFYKQLGS-----------------------------AGEGLPQVYYFGPCGKYNAMV CK1g2_Hsap EYRFYKQLSATGTGRPAGGAGAAQGQGGGCRRTPVRLSSAAEGVPQVYYFGPCGKYNAMV CK1g3_Hsap EYRFYKQLGS------------------------------GDGIPQVYYFGPCGKYNAMV CC1G_07108_Ccin -------MNG------------------------------TLGVPQVHYFGQEGLHNVLV CC1G_01170_Ccin ECRSYRILAG------------------------------CTGIPQIYHFGQEGLHNILV AqueK090_Aque EYRFYRTLGN------------------------------AVGIPQVYYFGPCGKYNAMV : .:* ::** * :* :: gish_Dmel MELLGPSLEDLFDICGRRFTLKSVLLIAIQLLHRIEYVHSRHLIYRDVKPENFLIGR--- Y106G6E.6_Cele MELLGHSLEDLFDLCDRHFSLKTVAMVAMQLIRRFEYVHTKHLFYGDVKPENFLIGR--- YCK1_Scer IDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGR--- YCK2_Scer IDLLGPSLEDLFDWCGRRFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGR--- YCK3_Scer IDLLGPSLEDLFEWCGRKFSVKTTCMVAKQMIDRVRAIHDHDLIYRDIKPDNFLISQYQR CK1g_Spur MELLGPSLEDLFDLCNRQFSLKTVLLLSTQLLHRIEYVHSKHLIYRDVKPENFLIGR--- CK1g1_Mmus LELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGR--- CK1g2_Mmus LELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGR--- CK1g3_Mmus LELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGR--- CK1g1_Hsap LELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGR--- CK1g2_Hsap LELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGR--- CK1g3_Hsap LELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGR--- CC1G_07108_Ccin IDLLGPNLEDLFDMCGRKFSIKTVCMAAKQMITRVQAVHEKSLIYRDIKPDNFLIGV--- CC1G_01170_Ccin IDLLGPSLEDLFDMCGRKFSIKTVCMAAKQMITRVQTIHEKNLIYRDIKPDNFLIGR--- AqueK090_Aque LELLGPSLEDLFDLCNRKFSLKTVLMIAIQLITRIEYVHTKHLIYRDVKPENFLMGR--- ::*** .*****: *.* *::*:. : *:: .. :* : *:* *:**:***:. gish_Dmel -------------TSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYMSIN Y106G6E.6_Cele -------------YSTRKQHVLHIIDFGLAKEYIDCDTGKHIAYREHKSLTGTARYMSIN YCK1_Scer -------------PGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSIN YCK2_Scer -------------PGQPDANKVHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSIN YCK3_Scer ISPEGKVIKSCASSSNNDPNLIYMVDFGMAKQYRDPRTKQHIPYRERKSLSGTARYMSIN CK1g_Spur -------------SSSKTQNTIHIIDFGLAKEYIDPETNKHIPYREHKSLTGTARYMSIN CK1g1_Mmus -------------QGNKKEHVIHIIDFGLAKEYVDPETKKHIPYREHKSLTGTARYMSIN CK1g2_Mmus -------------PGSKRQHSIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSIN CK1g3_Mmus -------------PGNKAQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSIN CK1g1_Hsap -------------QGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSIN CK1g2_Hsap -------------PGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSIN CK1g3_Hsap -------------PGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSIN CC1G_07108_Ccin -------------PGSKTANVIHIIDFGMAKHYRDPKTKVHIPYRERKSLSGTARYMSIN CC1G_01170_Ccin -------------PGTKGANVIHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSIN AqueK090_Aque -------------YGTPNQNIVNIIDFGLAKEYIDPDTTKHIPYREHKSLTGTARYMSIN . : : ::***:**.* * * **.***:***:********* gish_Dmel THMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRAT-PIEVLC- Y106G6E.6_Cele THLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRQT-AVEVLC- YCK1_Scer THLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKRST-NVYDLA- YCK2_Scer THLGREQSRRDDMEAMGHVFFYFLRGQLPWQGLKAPNNKQKYEKIGEKKRLT-NVYDLA- YCK3_Scer THFGREQSRRDDLESLGHVFFYFLRGSLPWQGLKAPNNKLKYEKIGMTKQKLNPDDLLLN CK1g_Spur THLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKE-------------------- CK1g1_Mmus THLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNT-PIEALC- CK1g2_Mmus THLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRAT-PIEVLC- CK1g3_Mmus THLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRAT-PIEVLC- CK1g1_Hsap THLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNT-PIEALC- CK1g2_Hsap THLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRAT-PIEVLC- CK1g3_Hsap THLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRAT-PIEVLC- CC1G_07108_Ccin THLGREQSRRDDLESLGHVFMYFLRGGLPWQGLRAATNKQKYEKIGEKKQTT-PIAELC- CC1G_01170_Ccin THLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYEKIGEKKQTT-PIKELC- AqueK090_Aque THLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGETKRST-PI----- **:*:*******:*::**:*:***** ******:* . * gish_Dmel DGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFDRKGYTDEGEF Y106G6E.6_Cele EGFPDEFAQYLRYARRLDF---------------------------F YCK1_Scer QGLPVQFGRYLEIVRSLSFEECPDY--E------------------- YCK2_Scer QGLPIQFGRYLEIVRNLSFEETPDY--E------------------- YCK3_Scer NAIPYQFATYLKYARSLKFDEDPDY--D------------------- CK1g_Spur ----------------------------------------------R CK1g1_Mmus ENFPEEMATYLRYVRRLDFFEKPDYEY-------------------L CK1g2_Mmus ESFPEEMATYLRYVRRLDFFEKPDYDY-------------------L CK1g3_Mmus ENFPEEMATYLRYVRRLDFFEKPDYDY-------------------L CK1g1_Hsap ENFPEEMATYLRYVRRLDFFEKPDYEY-------------------L CK1g2_Hsap ENFPEEMATYLRYVRRLDFFEKPDYDY-------------------L CK1g3_Hsap ENFP-EMATYLRYVRRLDFFEKPDYDY-------------------L CC1G_07108_Ccin EGFPEEFTIYMNYVRKLGFEETPDYDFL------------------- CC1G_01170_Ccin EGFPEEFGIYLNYVRKLGFEETPDYDFL------------------- AqueK090_Aque ----------------------------------------------E