CLUSTAL W (1.83) multiple sequence alignment mnb_Dmel YEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENK DYRK1B_Mmus YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK DYRK1A_Mmus YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK mbk-1_Cele ILSDTPVGKGSFGQVTKAYDTLNKEEVAIKIIKNKKTFFDQAQIEIHLLELTNAHDKDNK DYRK1B_Hsap YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK DYRK1A_Hsap YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK Dyrk1_Ddis FEIISSLGKGSFGQVVKAFDSVLKEYVAIKIIKNKVPFYNQALIEIRLLELMNNKDPEDQ DYRK1_Spur YEIDSLIGKGSFGQVAKAYDHQEQEYVAIKIIKNKKPFLNQAQIEVRLLELMNKHDADSK AqueK110_Aque ------------------------------------------------------------ AqueK111_Aque YEIDSLIGKGSFGQVVKAFDLEEREWVAIKVIKNKRAFYQQALIEKRLLELLNSRDPEGK GK031_Glam YCAERPLGQGSFGRVVLAKDTVNNAYVAIKIMKAGKLFTHKGREEAEIMSLLSDEDPPIS mnb_Dmel YYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLST DYRK1B_Mmus YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT DYRK1A_Mmus YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT mbk-1_Cele YNIVTLKGHFVHRAHLCLVFELLSYNLYDLLKNTSFRGVSLNLARKFAQQLGKTLLFLSS DYRK1B_Hsap YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT DYRK1A_Hsap YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT Dyrk1_Ddis YKIIKLKHHFKFRNHLCIVTELLSYNLYDLLRNTHFHGVSLNLIKKFAHQILTALFFMST DYRK1_Spur YYIVKLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT AqueK110_Aque ------------------------------------------------------------ AqueK111_Aque YYIVSLKRSFTFRGHLCFVFELLSYNLYELLRNTNFRGVSLNLTRKFAQQLCTALLFLST GK031_Glam CKF---IESFMQGNHYCIVMEALGSNLYHLLKSTKMQGFPLQTIRVWARKYLTSFKKLQH mnb_Dmel PELNIIHCDLKPENILL--CNPKRSAIKIVDFGSSCQLGQ-RIYHYIQSRFYRSPEVLLG DYRK1B_Mmus PELSIIHCDLKPENILL--CNPKRSAIKIVDFGSSCQLGQ-RIYQYIQSRFYRSPEVLLG DYRK1A_Mmus PELSIIHCDLKPENILL--CNPKRSAIKIVDFGSSCQLGQ-RIYQYIQSRFYRSPEVLLG mbk-1_Cele PELSIIHCDLKPENVLL--VNAKRSQIRVIDFGSSCQTGH-RIYQYIQSRFYRSPEVLLG DYRK1B_Hsap PELSIIHCDLKPENILL--CNPKRSAIKIVDFGSSCQLGQ-RIYQYIQSRFYRSPEVLLG DYRK1A_Hsap PELSIIHCDLKPENILL--CNPKRSAIKIVDFGSSCQLGQ-RIYQYIQSRFYRSPEVLLG Dyrk1_Ddis PEVDVIHCDLKPENILL--RNPKRSAIKIIDFGSSCHSNE-RMYKYIQSRFYRSPEILLE DYRK1_Spur PELNIIHCDLKPENILL--CNPKRSAIKIIDFGSSCQLGQ-RIYQYIQSRFYRSPEVLLG AqueK110_Aque ------------------------------------------------------------ AqueK111_Aque HDINVIHCDLKPENILL--CNPKRSAIRIVDFGSSCQVGS-RMFQYIQSRFYRSPEVLLG GK031_Glam ESIRIIHTDCKPENTLIPFNNTCVEDIRIVDFGSAVRYPEGQMFLYIQSRYYRAPEVLLL mnb_Dmel IQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYL----------- DYRK1B_Mmus TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPPAPMLEQ-APKARKY DYRK1A_Mmus MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQ-APKARKF mbk-1_Cele IAYDTKIDMWSLGCILVEMHTGEPLFAGSSEVDQMMKIVEVLGMPPKEMLDI-GPKTHKY DYRK1B_Hsap TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQ-APKARKY DYRK1A_Hsap MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQ-APKARKF Dyrk1_Ddis LEYSFSIDMWSLGCILVEMHVGEPLFSGQNEQDQLTKIIEVLDLPPSHMIDS-SPKAKKF DYRK1_Spur ISYDMAIDMWSLGCILVEMHTGEPLFSGSNELDQMNKIIEVLGMPPNHIIEQ-APKAHKY AqueK110_Aque -------------------------------------------------------RRDRF AqueK111_Aque IPYDLAIDMWSLGCILVEMHTGEPLFSGKDEIDQMSKIVEVLGIPPPHVLER-SARRDRF GK031_Glam QPYDYQIDIWSIAAILFEMHTGKVLFPAKSSEILCYMMVDILGYPPKEMIMDEEQKQ--- mnb_Dmel ------------------------------------------------------------ DYRK1B_Mmus FERLP-GGGWTLRRTKELRK--------D-YQGPGTRRLQEVLGVQTGGPGG-------- DYRK1A_Mmus FEKLP-DGTWSLKKTKDGKR--------E-YKPPGTRKLHNILGVETGGPGG-------- mbk-1_Cele FDKTE-DGIYYCKKTRDGYR--------HTYKAPGARKLHEILGVTSGGPGG-------- DYRK1B_Hsap FERLP-GGGWTLRRTKELRK--------D-YQGPGTRRLQEVLGVQTGGPGG-------- DYRK1A_Hsap FEKLP-DGTWNLKKTKDGKR--------E-YKPPGTRKLHNILGVETGGPGG-------- Dyrk1_Ddis FTKDPINSTYQLKKNEKLKT--------N-V-EFCKKKLSEIIGVETGGPQS-------- DYRK1_Spur FIKT--EKTWVLKRSRDGKK----------YKSPRTRKLQDILGVELGGPGG-------- AqueK110_Aque FERES-GGTWVLKRQRDGRK--------DHHRRPGSRSLYEVLGGDKGGPGG-------- AqueK111_Aque FERES-GGTWVLKRQRDGRK--------DHHRRPGSRSLYEILGGDKGGPGG-------- GK031_Glam ISNSLK-RYFKMRKQEDAELFHLNENAFPHQVVPDSYLLNKSVIEMAEAQKERIFGRPLR mnb_Dmel ------------------YLKFKDLILRMLDFDPKTRVTPYYALQHNFF DYRK1B_Mmus ------RRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFF DYRK1A_Mmus ------RRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF mbk-1_Cele ------RRLGEPGHSVEDYSKFKDLIKRMLQFDPKQRISPYYVVRHPFL DYRK1B_Hsap ------RRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFF DYRK1A_Hsap ------RRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF Dyrk1_Ddis ------RRKNEPGHALVDYLKFLDLIEKMLIYDPQKRITPLEALQHSFF DYRK1_Spur ------RRAGEPGHTVSDPHKFKDPILRMLEYDPASRIKPYYALQHSFF AqueK110_Aque ------LRKGDSGHTPNDYYKFRDLVLQMLDYDPETRIKPLAALKHPFF AqueK111_Aque ------LRKGDSGHTPNDYYKFRDLVLQMLDYDPETRIKPLAALKHPFF GK031_Glam ELIRNPVMTQYEGHTSADYEEFEEFLSKILVYDPKRRWTIDEALNSRFL .* : : ::* ::* * .:. *: