CLUSTAL W (1.83) multiple sequence alignment smi35A_Dmel YEILEVIGK-GSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADG Dyrk3_Dmel YEMLKIIGK-GSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYN DYRK4_Mmus YEVLEMIGK-GSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKDN DYRK3_Mmus YEVLKIIGK-GSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG DYRK2_Mmus YEVLKVIGK-GSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDN mbk-2_Cele YEVLKVIGK-GSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDG C36B7.2_Cele YTIDKVIGQ-GCYGVVGEATDGKTKQKVAIRMVS---KLAPRIYRETEMIMYISSIDPDH C36B7.1_Cele YSIDEVLSS-GYYAQVFRCTDKKTDKKVCIKLKN---RNLSTTYEETIILLRIHQLNRQN DYRK4_Hsap YEVLETIGK-GSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDN DYRK3_Hsap YEVLKIIGK-GSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG DYRK2_Hsap YEVLKVIGK-GSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDN Dyrk2_Ddis FEIVSILGQ-GSFCQVVKGYDYKTGEMVALKILRNQKRFHNQALTEIKILEYLKTNDPNS 5306_Tthe YEIKEFLGK-GSFGQVLKVFDHKRKEYAALKVIRNKQKFHEQALIELNILHYIKEKDYDN 5356_Tthe YELIEALGK-GSFGQVIKVFDHKRKEYSALKIIRNKKNFYNQAIVELNILKYIKDNDPQN 5655_Tthe YELLECLGK-GSFGSVVKVFDHKRKEFLALKVIRNKKKFHNQALIELNILSYIKEQDKDE DYRK2_Spur YEVLKILGK-GSFGQVVKVYDHKTNQHIAVKMVRNEKRFHRQAQEEIRILEHLRKQDKDN DYRK4_Spur YEILEVIGK-GSFGQVVKAFDHKLGEMIAIKIIRNKKRFHHQALIEVKILDALRRKDRDN CC1G_13957_Ccin YEVVDTLGK-GSFGQVLNCRDHCTGESVAVKIIRNKKRFHHQALVEIKILDNLRKWDADE AqueK112_Aque YEIREIIGK-GSFGQVVKVFDHKTNQHIALKIIRNKKRFHHQALVEVKILDSLRKRDRDN AqueK113_Aque YEVLKVLGK-GSFGQVLKAYDHKMQTHIALKVVRNEKRFHRQAQEEVKILEHLRRQDKDN DYRK2_b_Smoe YEILGKLGR-GSFGQVLKCTDHKYKVPRAIKIIRNKKQFTQQAFIEINLLEFLRNKAAEE DYRK2_a_Smoe YEILGKLGR-GSFGQVLKCTDHKYKVPRAIKIIRNKKQFTQQAFIEINLLEFLRNKAAEE GK034_Glam YELVSKLGS-GSFGKVYKALDHKEQQFVALKIIKNRKRFQRQGLVEVKILELLRDNDPNG GK033_Glam YKLLKMVGS-ATFSNVFSCLDLKDNVTYCLKIIKQEKEFFDQAIDEVHLLELLKDIDPNN GK032_Glam YEIYKTIFEDSAFSVTLKARDLKEGKDVCLKVVNNEKDTLDQCLNEIRLLTYINKHDPTG : : : . : . * .::: * :: : smi35A_Dmel --SHNVIHMLDYTYFRKHLCITFELMSLNLYELIKK-NN-----------YNGFSMSLIR Dyrk3_Dmel --TMNIIHMFDYFTFRNHTCITFELLSINLYELIKK-NG-----------FKGFSLQLVR DYRK4_Mmus --NHNVVHMKDFFYFRNHLCITFELLGINLYELMKN-NS-----------FHGFNLSIVR DYRK3_Mmus --SMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK-NK-----------FQGFSVQLVR DYRK2_Mmus --TMNVIHMLENFTFRNHICMTFELLSMNLYELIKK-NK-----------FQGFSLPLVR mbk-2_Cele --THNIIHMLDYFNFRNHKCITFELLSINLYELIKR-NK-----------FQGFSLMLVR C36B7.2_Cele --TFDCVRMLDYNVFRGFHYVVTDLFDTSVKKYIKE-HH-----------PNGIALENVA C36B7.1_Cele --NSNCVRMLDYDHFRGHHFIVLENYQTDLASYLCGRSK-----------LTP---REYI DYRK4_Hsap --TYNVVHMKDFFYFRNHFCITFELLGINLYELMKN-NN-----------FQGFSLSIVR DYRK3_Hsap --SMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK-NK-----------FQGFSVQLVR DYRK2_Hsap --TMNVIHMLENFTFRNHICMTFELLSMNLYELIKK-NK-----------FQGFSLPLVR Dyrk2_Ddis --TASIVHLNNYFYFRNHLILTFELLSMNLYDFLKV-NH-----------FQGYNLNLVR 5306_Tthe --QTNIVKIRDFVIFRNHVCLVFELLSINLYDLLRN-NK-----------FQGLSLELIR 5356_Tthe --QTNIVKIKDFVIFRSHVGLL-------------------------------------- 5655_Tthe --ATNIVRIKDFVIFRKHV----------------------------------------- DYRK2_Spur --NMNLIHMFESFSFRNHICITFELLSMNLYELIKK-NK-----------FQGFSLQLVR DYRK4_Spur --SHNVVHMREYFYYRNHLCITFELLGMNLYELIKK-NN-----------FQGFSVALIR CC1G_13957_Ccin --KHHVLKMTEHFYFRNHLCIATELLSINLYELIKA-NG-----------FVGFTTALIR AqueK112_Aque --QYNIIHMFDYFYFRNHLCITFELMGMNLYELIKK-NN-----------FQGFSISLIR AqueK113_Aque --AHNIIHMIDHFTFRNHVCITFELLSMNLYELIKK-NK-----------FQGFSLALVR DYRK2_b_Smoe GVDYNIVTIYESFEFRGHLCLSFAVHDISLFDMLKK-NH-----------FEGFNLSLVK DYRK2_a_Smoe GVDYNIVTIYESFEFRGHLCLSFAVHDISLFDMLKK-NH-----------FEGFNLSLVK GK034_Glam --DQCCVKVLSSFYFRSHLCIAFELLSINLYELLTK-KD-----------LKGLSLSLVR GK033_Glam --NINIIKIHDYFYFREHLLLKFTLLGEDLYTHFNR-REK-------KGQPNDYTIPVIR GK032_Glam --K-HFVRMTDYFYYGHRLIIIFELLTSNLFSYYSA-REAALPRTLLNPLATIFTMPRLQ : : . : smi35A_Dmel RFCNSIVKCLRLLYKENIIHCDLKPENILLKQRG------SSSIKVIDFGSSCYVDRK-I Dyrk3_Dmel KFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQG------RSGIKVIDFGSSCFENQR-I DYRK4_Mmus RFTFSILKCLHMLYVEKIIHCDLKPENIVLYQRG------QVTVKVIDFGSSCYEHQK-V DYRK3_Mmus KFAQSILQSLDALHKNKIIHCDLKPENILLKHHG------RSATKVIDFGSSCFEYQK-L DYRK2_Mmus KFAHSILQCLDALHKNRIIHCDLKPENILLKQQG------RSSIKVIDFGSSCYEHQR-V mbk-2_Cele KFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQG------RSGIKVIDFGSSCFDDQR-I C36B7.2_Cele AMGRKILKGLVFLHEHNIVHGDLKPENIMLNLAN------PNDVKLGDFGLSRFAKPYHD C36B7.1_Cele PMIKSIVHGLKFLHQNKIIHGDLKPANVLLNEWN------RNNLKLTDFGLSTFVNQGPF DYRK4_Hsap RFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKG------QASVKVIDFGSSCYEHQK-V DYRK3_Hsap KFAQSILQSLDALHKNKIIHCDLKPENILLKHHG------RSSTKVIDFGSSCFEYQK-L DYRK2_Hsap KFAHSILQCLDALHKNRIIHCDLKPENILLKQQG------RSGIKVIDFGSSCYEHQR-V Dyrk2_Ddis RFGAQILTSLRFLSKRNIIHADLKPENILLKSPT------KSGIKLIDFGSSCFENEQ-I 5306_Tthe RFAIQLLNAISFLKENRIIHCDLKPENVLLKQPN------KSGIKIADFGSSCFDDQV-M 5356_Tthe -----------FLTKANIIHCDLKPENILLKQEN------KSGIKIVDFGSSCFENQR-V 5655_Tthe -----ILNSINFLRKNRIIHCDLKPENILLKQAN------KSGVKLIDFGSSCFENER-L DYRK2_Spur KFAHSLLQCLEGLHRNKIIHCDLKPENILLKQQG------RSGIKVIDFGSSCYEHQR-I DYRK4_Spur RFAFSLLQCLRMLHKERIIHCDLKPENILLRQKG------QSTIKVIDFGSSCYEHQR-V CC1G_13957_Ccin RFTTQMLMSLSLMRHHRIVHCDLKPENVLLRHPA------KSAIKVIDFGSSCLEHEK-- AqueK112_Aque RFAYSMLQCLKILYRERIIHCDLKPENILLRLRG------QSSIKVIDFGSSCYEHQR-V AqueK113_Aque KFAHSILQCLDSLYRNRIIHCDLKPENILLKQPG------RSGIKVIDFGSSCYEYQR-V DYRK2_b_Smoe CFARQVLVSLQFLHRARIIHGDLKPENILLQQPA------SPKIKLIDFGSSCFEHER-I DYRK2_a_Smoe CFARQVLVSLQFLHRARIIHGDLKPENILLQQPA------SPKIKLIDFGSSCFEHER-I GK034_Glam KFSLQLLIAFAYARKLRIIHADVKPENILLREPD------KSSIKVIDWGSGAMVSET-I GK033_Glam DMARQVLKALDYIHRLGITHLDLKPENLLHGDKNFIGGVNEPSVTLVDFGSSSFIFDK-M GK032_Glam HIARQILESLDFLHRLNILHLDLKHENLLLVNED----DDSFDIRLVDIGSSAFLYDE-C : * *:* *:: : * * . smi35A_Dmel YTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVE--------QL Dyrk3_Dmel YTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESD--------QL DYRK4_Mmus YTYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYTGYPLFPGENEVE--------QL DYRK3_Mmus YTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD--------QL DYRK2_Mmus YTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGD--------QL mbk-2_Cele YTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDEND--------QL C36B7.2_Cele HVQCQSMFYRAPEAFVRGRYNGATDMWSFGCTVAEMVSGKIFLAGDNCDD--------QF C36B7.1_Cele FRDYQTLYYKAPEVFCQGKVSVEIDIWSLGCVAAEIVRGTPLFVGDNYFD--------QF DYRK4_Hsap YTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVE--------QL DYRK3_Hsap YTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD--------QL DYRK2_Hsap YTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGD--------QL Dyrk2_Ddis FTYIQSRFYRSPEVILGTKYDKSIDIWSLGCILVEIFTGVPLFPGSDEPE--------QL 5306_Tthe YTYIQSRYYRSPEVILGIPYGTEIDMWSFGCIIAELFLGYPIFPGEDENE--------QM 5356_Tthe YTYIQSRFYRAPEIILGLPYGKAIDMWSFGCIMAELYIGYPLFPGENEAE--------QF 5655_Tthe YTYIQSRYYRAPEVILGLPYDTSIDMWSFGCIMAELFIGYPIFPGEDEQE--------QI DYRK2_Spur YTYIQSRFYRAPEVILGGKYGMPIDMWSLGCILAELLTGYPLLPGEDEGD--------QL DYRK4_Spur YTYIQSRFYRSPEVILGLPYGLPIDMWSFGCILAELYTGYPLFPGENEVE--------QL CC1G_13957_Ccin ---------------------------------TELYTGFPIFPGENEQE--------QL AqueK112_Aque YTYIQSRFYRSPEVILGLPYSMAIDMWSLGCILAELYTGYPLFPGENEVE--------QL AqueK113_Aque YTYIQSRFYRAPEVILGGKYGMSIDMWSFGCILAELLTGYPLFPGEDEGD--------QL DYRK2_b_Smoe YTYIQSRFYRAPEVILGLPYDMMIDVWSFACILAELFTGYPLFPGEDEVE--------QL DYRK2_a_Smoe YTYIQSRFYRAPEVILGLPYDMMIDVWSFACILAELFTGYPLFPGEDEVE--------QL GK034_Glam YSYIQSRFYRAPEVILGLPYGQEIDIWSIGCVLCELYTGLPIFPGDDERD--------QL GK033_Glam HSYIQSRSYRAPEVILATPYDSRADIWSFGCVVCELLTGRVLFPNYSVAT--------IL GK032_Glam STYVQSRSYRCPEVILGLPYDGRADVWSLGPILTELITGKVMFPIPQKADEDHKPYASML *: * :: . : smi35A_Dmel ACIMEVLGLPPKVLISVARRRRLFFDS-RDAPRCITN----------------------- Dyrk3_Dmel ACIIEVLGMPNKNILA-------------------------------------------- DYRK4_Mmus ACIMEVLGLPPAHFTQTASRRQVFFDS-KGLPKNINN----------------------- DYRK3_Mmus ACMIELLGMPPQKLLEQSKRAKYFINS-KGLPRYCSVST--------------------- DYRK2_Mmus ACMIELLGMPSQKLLDASKRAKNFVSS-KGYPRYCTVTT--------------------- mbk-2_Cele ALIIELLGMPPPKSLETAKRARTFITS-KGYPRYCTATS--------------------- C36B7.2_Cele YLMQEVINIPPPVFFDTFYTNYYFFSTLKEAPKHIVI----------------------- C36B7.1_Cele ALIQEFFGKPSRKLFNTWGGIHQFYTE-YFFPRHCFEWL--------------------- DYRK4_Hsap ACIMEVLGLPPAGFIQTASRRQTFFDS-KGFPKNITN----------------------- DYRK3_Hsap ACMMELLGMPPPKLLEQSKRAKYFINS-KGIPRYCSVTT--------------------- DYRK2_Hsap ACMIELLGMPSQKLLDASKRAKNFVSS-KGYPRYCTVTT--------------------- Dyrk2_Ddis ACIMEVLGAPPKSVIDNSTRKDIFFED-DGTPKPVKNS---------------------- 5306_Tthe GYIMELLGAPDSEFLKKCSRKKYFFDQ-NDQPLQIPN----------------------- 5356_Tthe QMFMEILGIPEEEFVENCPRRNVFFEN-NKTPKVVKN----------------------- 5655_Tthe GYIWEIIGAPSKDFLQNCTRRKYFFNE-DYTPKLIPN----------------------- DYRK2_Spur ACMIEVMGMPSQNLIDTSKRSKNFINS-KGQPRYCTVTT--------------------- DYRK4_Spur ACIMEIFGLPPP------------------------------------------------ CC1G_13957_Ccin SCIMEVLGVPDKEYINRSSRKKLFFDT-NGAPRPVVN----------------------- AqueK112_Aque ACIIEIFGLPDPALLAEAQRKKLFFDS-RGNPRCVTN----------------------- AqueK113_Aque ACMMEVLGLPSQKMIESTKRGRTFFSS-KGHPRYTTVNI--------------------- DYRK2_b_Smoe AYMMEVLGTPPLSLISQAKRKKMFFDS-DNKPRIVPN----------------------- DYRK2_a_Smoe AYMMEVLGTPPLSLISQAKRKKMFFDS-DNKPRIVPN----------------------- GK034_Glam GKICELLGMPPNDMIFKSPRKNDFFVN-IGTGMGVAGVSEGGNPIFSGNLQQLSSVNEYL GK033_Glam SRICSLIGPIPRDMIMSGRMGQRVLTF-GLVPY--------------------------- GK032_Glam AKLIGIIGPIPRDMILAGRESHKLFTK-DLFLF-ET------------------------ : .:. smi35A_Dmel --------------------TKGRKR-S-----------PGSKS--------LAHILH-C Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus --------------------NRGGKR-Y-----------PDSKD--------LTMVVK-T DYRK3_Mmus ----QTD-GR--VVLLGGRSRRGKKRGP-----------PGSKD--------WATALKGC DYRK2_Mmus ----LSD-GS--VVLNGGRSRRGKLRGP-----------PESRE--------WGNALKGC mbk-2_Cele ----MPD-GS--VVLAGARSKRGKMRGP-----------PASRS--------WSTALKNM C36B7.2_Cele -----TDHGP---IVSFIYTKAADHRKI-----------PGATP--------IGSFFTKT C36B7.1_Cele ----NPFNGDRTMEIEPHYKLAHPSRKP-----------PLTSS--------LVSKLPGG DYRK4_Hsap --------------------NRGKKR-Y-----------PDSKD--------LTMVLK-T DYRK3_Hsap ----QAD-GR--VVLVGGRSRRGKKRGP-----------PGSKD--------WGTALKGC DYRK2_Hsap ----LSD-GS--VVLNGGRSRRGKLRGP-----------PESRE--------WGNALKGC Dyrk2_Ddis --------------------TTGELY-T-----------IGTKS--------FKDSIR-S 5306_Tthe --------------------SRGKIR-M-----------PNSKN--------WKSVIG-C 5356_Tthe --------------------SRGKIR-T-----------PATKH--------INYYLR-C 5655_Tthe --------------------SKGKIR-V-----------PNSKI--------LKAVLQ-T DYRK2_Spur ----LPD-GT--TVLNGGRSRRGKVRGP-----------PGSKD--------LVKALKGC DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin --------------------SKGRRR-R-----------PGSKT--------LAQVLR-C AqueK112_Aque --------------------SKGKKR-R-----------PGSKD--------LSSAIK-T AqueK113_Aque ----NPD-GT--ASYTGGRSRRGKFRGP-----------PGTKD--------MSRALKGC DYRK2_b_Smoe --------------------SSGTRH-F-----------PSTKD--------LRMVVG-C DYRK2_a_Smoe --------------------SSGTRH-F-----------PSTKD--------LRMVVG-C GK034_Glam QATGRGA-GG--SEVPGIRLR--TTH-K-----------VNSKT--------LSGVLN-A GK033_Glam --------------E-HDEKNRQHFYF-----------TPQQGLLEYWLFGERCANLT-D GK032_Glam ---------R--EAILGNRDKAEGLRHAEIKGEDYVYVLPKKTTIKAML--GWDSHPE-Y smi35A_Dmel QDRYFIDFLQRCLEWDPAERMTPDEAAHHEFL Dyrk3_Dmel SDPLFLNFIRGCLEWDADKRLTPSEALKHPWL DYRK4_Mmus YDSSFLDFLRRCLVWEPSLRMTPEQALKHAWI DYRK3_Mmus GDYLFIEFLKRCLQWDPSARLTPAQALRHPWI DYRK2_Mmus DDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL mbk-2_Cele GDELFVDFLKRCLDWDPETRMTPAQALKHKWL C36B7.2_Cele EQKPFNNFILKVFKWMPASRITAKQALDHPFF C36B7.1_Cele NQKFLARFLMRCFEWDPTERIKSSFILNHPFF DYRK4_Hsap YDTSFLDFLRRCLVWEPSLRMTPDQALKHAWI DYRK3_Hsap DDYLFIEFLKRCLHWDPSARLTPAQALRHPWI DYRK2_Hsap DDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL Dyrk2_Ddis GDEDFDNFILDCLKWEPSQRITAEQGLKHDWI 5306_Tthe TDDNFIDFIKKCLVWEPSQRLTPRDALLHPWI 5356_Tthe PDENFIDFVSKCFTWKNHERMSPAEALVHDWI 5655_Tthe ESEDFTDFLTKCFVWEPQKRLKPSDALMHPWI DYRK2_Spur DDPLFLDFLKRCLEWDPSSRMTPSQALRHSWL DYRK4_Spur -------------------------------H CC1G_13957_Ccin NDEEFIDFIAKCLVWDPERRMKPQAAMRHPFV AqueK112_Aque SDLLFLDFIRRCLVWSASERMKPEEALQHAWI AqueK113_Aque DDPQFLDFLRHCLEWDPAIRMTPPQALRHPWL DYRK2_b_Smoe SDKSFVNFLSCCLKWDKEQRMTPQQLLKHEWI DYRK2_a_Smoe SDKSFVNFLSCCLKWDKEQRMTPQQLLKHEWI GK034_Glam PD-DFISFISLFLQWDPQRRCTPEVAMSHPWI GK033_Glam EEVLFSDFCRQALIVDPIKRPTAAMLLEHPFI GK032_Glam CDDLFLDFIETIMRIDPRKRPTAAEALEHPWL