CLUSTAL W (1.83) multiple sequence alignment HH498_Hsap IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRAN-TYCS------------KSDVDMFCRE HH498_Mmus IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRAN-TYCS------------KSDVDMFCRE C24A1.3_Cele IEFQESIGSGSFGKVYKGTYRGKLVAVKRYRAM-AFGC------------KSETDMLCRE HH498_Ddis FKTARKIGAGAFGDVYLVEWRNKNVAVKRVKIE-KILESGKS-------YQWIRDKFILE TNNI3K_Spur IEFLETIGSGSFGNVYKGYCRGKIVAIKRYRSS-AFSA------------KSDVDMFCRE AqueK135_Aque TMTEVVLGKGGWGEVKVVHFRGLKVAAKCLYE--VIIS------------PYNIGTFSRE AqueK499_Aque KETGKELGRGAYGVVTEVIVSGTTCAAKKLHD--VIVQ------------DFTLRRFGDE AqueK622_Aque ------------------------------------------------------------ AqueK623_Aque KETGKELGRGAYGVVTEVIVSGTTCAAKKLHP--AIIQ------------GYTLKRFCDE AqueK624_Aque ------------------------------------------------------------ AqueK625_Aque ------------------------------------------------------------ AqueK626_Aque TMTEVVLGKGGWGEVKVADFRGLKVAAKCLYE--VIIS------------PYNIGTFSRE AqueK627_Aque TMTEVVLGKGGWGEVKVAGFRGLKVAAKCLYE--VIIS------------PYNIGTFSRE AqueK628_Aque ------------------------------------------------------------ AqueK629_Aque ------------------------------------------------------------ AqueK630_Aque ------------------------------------------------------------ AqueK631_Aque ------------------------------------------------------------ AqueK632_Aque ------------------------------------------------------------ AqueK633_Aque KINKP--------------------------D--EDSK------------QAFLVKLSHE AqueK634_Aque ------------------------------------------------------------ AqueK635_Aque ---GEELGRGAYGVVLEVKVSGFSCAGKKLHD--AIAG------------EFLVKSFVNE AqueK636_Aque ILTKEELGRGSYAAVTVGIFRGLRVAVKSLHN--IIIS------------DFNLALFSRE AqueK637_Aque TLTKEELGRGSYAVVTVGIFRGLRVAVKSLHK--IIIS------------DYNRGIFSRE AqueK638_Aque KETGKELGRGAYGVVTEVIVSGTTCAAKKLHD--AIVQ------------SFTLRRFGDE AqueK639_Aque IYFKESLGSGAYGSVYRAKCDHLVCAAKVLHP--MFFASSDP------AVKDTIAKFKSE AqueK640_Aque IMEEKKLGEGAYGVVKLANYHGLTVAVKKLLP--SFFPTDVVVNKLDEEAQIILESFFNE AqueK641_Aque IYNEQRLGSGAFGAVCKAKCDRLPCAAKFLHP--TFSLQSD---------SWVAEKFVQE AqueK642_Aque -----------------------------------------------------LKKFNEE AqueK643_Aque TMTEVVLGKGGWGEVKVAGFRGLKVAAKCLYE--VIIS------------PYNIGTFSRE AqueK644_Aque TMTEVVLGKGGWGEVKVAGFRGLKVAAKCLYE--VIIS------------PYNIGTFSRE AqueK645_Aque TLMEEELGRGSYAVVTVGIFRGLKVAVKSLHN--IIIS------------DVNLALFSRE AqueK646_Aque --------------VYLGTFRSIDVVVKKINRPPDVWE------------CCTRKTFQKE AqueK647_Aque TMTEVVLGKGGWGEVKVAGFRSVKVAAKCLYD--VIIS------------PYNIGIFSRE AqueK648_Aque KETGKELGRGAYGVVTEVIVSGTTCAAKKLHD--AIVQ------------EDTLRRFGDE AqueK649_Aque AANGKLLGNGSYGVVQTVKYKGKELACKTYRD--YLINSAD---------HNMRGAFLKE HH498_Hsap VSILCQLNH-PCVIQFVGACLNDPSQF-AIVTQYISGGSLFSLLHE-------------- HH498_Mmus VSILCQLNH-PCVVQFVGACLDDPSQF-AIVTQYISGGSLFSLLHE-------------- C24A1.3_Cele VSILSRLAH-PNVVAFVGTSLDDPSQF-AIITEFVENGSLFRRENG-------------- HH498_Ddis AVLMVKLSNFSSFVKLYATCIE-E-KELLLVLEFCDNGSLYTILNTIPIGGAGANNNNNN TNNI3K_Spur VSILCRLDS-PYVIRFVGACIEDPSHF-AIVTQYVAGGSLFSLLHV-------------- AqueK135_Aque MNIASKIRH-PNLLQFIGATT---EGNAIILTELMPTS-LRMEL---------------- AqueK499_Aque VLLHSQQRH-PNIVQLIGVYYPPHSQLPMLVMEYLPLS-LTQCL---------------- AqueK622_Aque ------------------------------------------------------------ AqueK623_Aque VLLHSQQRH-PNIVLLIGVYYPRRSKLPMLVMEYLPLS-LTQCL---------------- AqueK624_Aque ------------------------------------------------------------ AqueK625_Aque ------------------------------------------------------------ AqueK626_Aque MNIASKIRH-PNLLQFIGATT---EGNPIILTELMPTS-LRKEL---------------- AqueK627_Aque MNIASKIRH-PNLLQFIGATT---EGNPIILTELMPTS-LRKEL---------------- AqueK628_Aque ----------------------------------MPTS-LRKEL---------------- AqueK629_Aque -------HH-PNIVNFLGVYYAPHSTLPTLVMEYLPRT-LTSCL---------------- AqueK630_Aque -------RH-PNIVLLIGVYYPPRSQLPMLVMEYLPLS-LTQCL---------------- AqueK631_Aque ------------------------------------------------------------ AqueK632_Aque ------------------------------------------------------------ AqueK633_Aque IILHSRQRH-PNIVQLLGVGHPD----LTIVTEYFPLG-LSVLL---------------- AqueK634_Aque -------------------TT---EGNPIILTELMPTS-LRKEL---------------- AqueK635_Aque CVNHSHLRH-PNIVQLMGVYFPPDSTIPILVMERLQVS-LAQCL---------------- AqueK636_Aque MDIASRVRH-PNLVQFIGATK---VDNPLILTELMSTS-LNQEL---------------- AqueK637_Aque MNIASQVRH-PNLVQFIGATK---VGNPLILTELMSTN-LYQEL---------------- AqueK638_Aque VLLHSQQRH-PNIVQLIGVYYPPRSQLPMLVMEYLPLS-LTQCL---------------- AqueK639_Aque CELLSSLQH-PNIVQFLGEFTNS-AGETALVMELMDES-LTSFI---------------- AqueK640_Aque CNKLSQIRH-PNVIQLLGITLDKETNLPAIVMELMHES-LTQLL---------------- AqueK641_Aque CSFLASLRH-PHIVQFLGLHTDPKSGSIALLLELMDEN-MTTFL---------------- AqueK642_Aque ILLHSQQRH-PNIVQLIGVYYPPRSKVPMLVMEYLPFT-LRESL---------------- AqueK643_Aque MNIASKIRH-PNLLQFIEATT---EGNPIILTELMLTS-LRKEL---------------- AqueK644_Aque MNIASKIRH-PNLLQFIGATT---EGNPIILTELMPTS-LRKEL---------------- AqueK645_Aque MSIASQIRH-PNLVQFIGATK---VGNPLILTELMSTS-LYKKL---------------- AqueK646_Aque VEQLSRLQC-PYVVQFMGAIMVPSSGLYCLVMEYMPNNDLHTLMHV-------------- AqueK647_Aque MNIASKIRH-PNLLQFIGATT---EGNPIILTELMPTS-LRKEL---------------- AqueK648_Aque VLLHSQQRH-PNIVQLIGVYYPPHSQLPMLVMEYLPLS-LTQCL---------------- AqueK649_Aque CHNAMRLNH-PNVVRSCGFYFPQEAIFPSLVMELLPHC-LNKIL---------------- HH498_Hsap QK---R--I-LDLQSKLIIAVDVAKGMEYLHNL-TQPIIHRDLNSHNILLYED------- HH498_Mmus QK---R--I-LDLQSKLIIAVDVAKGMEYLHSL-TQPIIHRDLNSHNILLYED------- C24A1.3_Cele ER---KNYRVMDPAFRLRISLDVARGMRYLHESAAKPVIHRDLNSHNILIHAD------- HH498_Ddis NN--NNDII-QSLPSINTLSLNIANGMNYLHSLK-PQIIHRDLTSQNILIDRN------- TNNI3K_Spur QK---R--N-IDLQSKMTIAVDVAHGMDYLHNL-PHPIIHRDLNSHNILLDEF------- AqueK135_Aque ES-----GG-VAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVL----------- AqueK499_Aque ER-----EE-LPLQMKYSILLDVAKGLCYLHGK-RPPIVHRDLTANNVLLTSS------- AqueK622_Aque ------------------------------------------------------------ AqueK623_Aque ER-----EE-LPLQMKYSILLDVAKGLCYLHGK-RPPIVHRDLTANNVLLTSS------- AqueK624_Aque -----------------------------------HPILHRDVSSANVLLQPMI-----G AqueK625_Aque -------------------------------------IIHRDVSSANVLLEN-------- AqueK626_Aque ES-----GG-VAYPAILSISLDVACALNYLHLFKPHPILHR------------------- AqueK627_Aque ES-----GG-VAYPAILSISLDVACALNYLHLFKPHPILHR------------------- AqueK628_Aque ES-----VG-LAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGG--LG AqueK629_Aque ES-----NS-LKIQMKYAILLDVAKGLIYLHQK-NPCVIHRDLTANNVLLTHN------- AqueK630_Aque ER-----EE-LPLQMKYSILLDVAKGLCYLHGK-RPPIVHRDLTANNVLLTSS------- AqueK631_Aque RR-----NR-LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTR---PA AqueK632_Aque -----------------------MLGLCYLHGK-RPPIVHCDLTANNVLLTSS------- AqueK633_Aque DD---KRHK-IPDWMKSRLMLDISQGLRYLHSQ-TKPIIHFGLTSNNILLTEH------- AqueK634_Aque ES-----GG-VAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMG-----G AqueK635_Aque IE-----AT-LPLKLKYSILLDIANGLNYFHHR-TPPIIHRDLTAQNVLLTKS------- AqueK636_Aque HR-----NQ-LTNQQILSIAQDVALGLNYLHLFKPQAIIHRDISSPNVLLKPCTG---PA AqueK637_Aque QR-----NR-LTNHQIHSIAQDVALALNYLHLFKPLPIIHRDVSSPNVLLKPCTG---PG AqueK638_Aque ER-----EE-LPLQMKYSILLDVAKGLCYLHGK-RPPIVHRDLTANNVLLTSS------- AqueK639_Aque DGYHPQDNP-VPMHLMIDFSHDISLALYYLHN---NGIIHRDLSSNNVLLLGR------- AqueK640_Aque RR---T-ST-LPLFVEVNITHDIAKALSYLHGAFHPPIVHRDLSSNNILISRD------- AqueK641_Aque QK--RADQL-LPLHLLLDFAHDITLAMLYLHN---NGIVHRDLSSNNVLLLGQ------- AqueK642_Aque EH-----HK-LPLQMKYSILSDVAKGLCYLHGK-RPAIVHRDLTANNVLLTPL------- AqueK643_Aque ES-----GG-VAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQYVG-----N AqueK644_Aque ES-----GG-VAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQITG-----G AqueK645_Aque QD-----TE-LTKQQIMSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTG---PA AqueK646_Aque KK-----TQ-LSKLEKTQIIRDIAAGMAYLHSF---PIIHRNLIPSNVLIGE-------- AqueK647_Aque ET-----GG-VAYPAILSISLDVGCALNYLHLFKPHPILHRDVSSANVLLQLMGGGGYGY AqueK648_Aque ER---A-EE-LPLQMKYSILLDVAKGLCYLHGK-RPPIVHRDLTANNVLLTSS------- AqueK649_Aque EQ-----GM-VPYHYKPFVLADVANGLSYLHS---QNIMHRDLTANNVLLTEK------- HH498_Hsap -GHAVVADFGESRFLQSLD-----E--DNM--TKQPGNLRWMAPEVFT----------QC HH498_Mmus -GHAVVADFGESRFLQSLD-----E--DNM--TKQPGNLRWMAPEVFT----------QC C24A1.3_Cele -GRSVVADFGESRFVCQRE-----D--ENL--TKQPGNLRWMAPEVFS----------QS HH498_Ddis -GIAKIADFGISRFKNDIG-----D--KTM--T-SIGNPRFRSPEVTKG----------- TNNI3K_Spur -GHAEVADFGESRFVKSMH-----E--DNM--TKQPGNLRWMAPEVFS----------QN AqueK135_Aque ------------------------------------------------------------ AqueK499_Aque -YSAKISDLGVSRLADTFK-----K--HHL--TTAPGNAMVMPPEALED----------N AqueK622_Aque --------------------------------------PLYAAPEAANP----------- AqueK623_Aque -YSAKISDLGVSRLADTFK-----M--HEL--TTAPGNAMVMPPEALKD----------N AqueK624_Aque VWRAKVSDYGSANLQ--H-------SI-IR--SVNPGGPLYAAPEAANP----------- AqueK625_Aque KWKTKISDFGSAKFA--R-------A--AV--TEAPGAAVYSAPESIRT----------- AqueK626_Aque ------------------------------------------------------------ AqueK627_Aque ------------------------------------------------------------ AqueK628_Aque GWKAKVSDYGSANLQ--H-------LI-IR--SVNPGGPLYAAPEAGNP----------- AqueK629_Aque LLQAKISDLGVSRKWA--------D--TML--TKAPGNTMVMPPEALKD----------N AqueK630_Aque -YSAKISDLGVSRLVDTFK-----K--HHL--TMAPGNAMVMPPEALKD----------N AqueK631_Aque GFEAKVADYGTAKLV--Q-------VDSTG--TVMPGNVAYAAPEARDP----------- AqueK632_Aque -YSAKISDLGVSRLADTFK-----N--HHL--TTVPGNAMVMPPENLED----------N AqueK633_Aque -FQAKIADLATSRAFFD---------PSLT--NLDYGSFIFMPPELFSPDDR-----EEQ AqueK634_Aque VWRAKVSDYGSANLQ--P-------LI-GR--TTNPGNPVYSAPEAGNP----------- AqueK635_Aque -FTAKIADLGVSRIIDPGR-----P--RSH--TDVPGNPAVMPPEAFDD----------Q AqueK636_Aque GYEAKVSDYGTAKVV--Q-------AENTG--TVMPGNVAYAAPEAPIP----------- AqueK637_Aque GYEAKVANYGAAKLQ--Q-------GTSTG--TVMPGNTAYAAPEARDP----------- AqueK638_Aque -YSAKISDLGVSRLADTFK-----K--HHL--TTAPGNAMVMPPEALKD----------I AqueK639_Aque -IRAKITDLGVSKLHDAA--------GQHM--TQCPGAPVYMPPEALS----------QG AqueK640_Aque -YRAKVTDLGVSKVESSSF-----FQRMAN--TPAPGTMAYMAPEVRHI----------P AqueK641_Aque -RLAKVGDFGMSKLLFGTKCDSFLPRSISL--TQVPGCPVYMPPEAWL----------TP AqueK642_Aque -YSAKISDLGVSRLIDKFK-----S-HQQL--TQVPGNAIVMPPEALAT----------K AqueK643_Aque SWRAKVSDYGTVSLQ--P-------L--TK--TSNPGNPVYSAPESPYP----------- AqueK644_Aque TWKAKVSDYGTVSLQ--P-------L--AR--TSNPGNPVYSAPESPYP----------- AqueK645_Aque GYEAKVADYGTAKLQ--Q-------GTSTG--TVMPGNPAYAAPEARDP----------- AqueK646_Aque KMNAKVSDFGLYNTKVQTN---FYADLRKLCLKDGNKRPYYRAPEIIEK----------- AqueK647_Aque GWRAKVSDHGTVCLQ--S-------L--TS--TRNPGNLVYSAPESFNP----------- AqueK648_Aque -YSAKISDLGVSRLADTFK---------DL--TKAPGNAIVMPPEALKD----------N AqueK649_Aque -WTAKIADFGQAKVVKNK-------DFIKH--TSAPGTPVYMPPEARPISQGATIPDLQQ HH498_Hsap TRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADM-AYH-----HIRPPIG-----Y HH498_Mmus TRYTIKADVFSYALCLWELLTGEIPFAHLKPAAAAADM-AYH-----HIRPPIG-----Y C24A1.3_Cele GKYDRKVDVFSFALVIWEIHTAELPFSHLKPAAAAAEM-TYK-----RGRPTLPN-QPTA HH498_Ddis QKYSEKVDVFGFGMILYEMFTRRVPFHDYEQIAASFKI-AN------AERPPLPQ-T-I- TNNI3K_Spur TQYSIKADIFSYALCIWELLSGELPFAHLKPAAAAAEM-AYR-----STRPPIA-----I AqueK135_Aque ------------------------------------------------------------ AqueK499_Aque PVYDHKLDVFSYGCLILHVLTGQFPEPTNQFVPKPGKKKSFKKVPEWDRRSNYIK-D-IP AqueK622_Aque REHSPSMDVFSYGVLLLEMITRRIPLPE-------------------------------- AqueK623_Aque PVYDHKLDVFSYGCLILHVLTGQF------------------------------------ AqueK624_Aque REHSPSMDVFSYGVLLLEMI---------------------------------------- AqueK625_Aque RKQTTKMDSYSYGVLLCEMITCHFPNAE--KFE-T------------------VK---V- AqueK626_Aque ------------------------------------------------------------ AqueK627_Aque ------------------------------------------------------------ AqueK628_Aque REHSPSMDVFSYGVLLLEMITRRIPLPE-------------------------------- AqueK629_Aque PVYDHKLDVFSYGCLILHVLTGQF------------------------------------ AqueK630_Aque PVYDHKLDVFSYGCLILHVLTGQF------------------------------------ AqueK631_Aque DQHSPAMDVYSYSVLLMEMTLGSPPEMTMAEREVQ------------------AG-S-V- AqueK632_Aque PVYDHKLDVFSYGCLILHVLSGRFPQPTDQFIQKPGRAKSFKKVQEWDRRSKYIE-Q-IP AqueK633_Aque RKYDVKFDVFSFGCIMIHILSQQY------------------------------------ AqueK634_Aque REHSPSMDVFSYGVLLLEMITRRIPLPE--ERVGL------------------ID-G-I- AqueK635_Aque -PYDYKLDVFSYGCLI-------------------------------------------- AqueK636_Aque DQHSPAMDVYSYSVLLME------------------------------------------ AqueK637_Aque DQHSPAMDVYSYSVLLMEMNLRCP------------------------------------ AqueK638_Aque PVYDHKLDVFSYGCLILHVLTGQF------------------------------------ AqueK639_Aque TNYSEKLDVFSFGVLLIQMASCRF------------------------------------ AqueK640_Aque ADCSPAMDVFALGVIVI------------------------------------------- AqueK641_Aque PVYTEKLDMFSMGVLFLQMVTCREPNP--------------------------------- AqueK642_Aque PVYNEKVDVFTYGCLILHVLTCQFPEPTDAFVQYFMFWQ--SKVAEWDRRSKYIQ-K-IP AqueK643_Aque NQHSPAMDVFSYGVLLIEMVVCEFPDVG--KRVAQ------------------IK-A-I- AqueK644_Aque NQHSPAMDVFSYGVLLIEMVVCEFPDVG--KRVAQ------------------IK-A-I- AqueK645_Aque DQHSPAMDVYSYSVLLMEMNLRCPPEMTTAERARQ------------------SG-S-V- AqueK646_Aque NDFSTASDVYSFGIMLHELATQKRPFSDVDPCSNAMVW-V-MKLLM-GARPV-IP-S-Y- AqueK647_Aque REHSPAMDVFSYGVLLLEMVVCQFQDVE--KRVAQ------------------IK-A-I- AqueK648_Aque PVYDHKLDVFSYGCLILHVLTGQFPEPTNQFVRIPGK-EHFMRVPEWKRRSNYIE-D-IP AqueK649_Aque LEYSYTIDVFSFGVLILHMYLNKIPRIIDETVSDTRNPQLFYRRPPLDYFSQDIETA-IP HH498_Hsap SIPKPISSLLIRGWNACPEGRPEFSEVVMKL---------EECL HH498_Mmus SIPKPISSLLMRGWNACPEGRPEFSEVVRKL---------EECL C24A1.3_Cele QFPAHILSLIPQAWHPESSSRPDFVEIVA-------------LL HH498_Ddis --DHRWSNLIQICWDQNPNNRPSFDQIL--------------TI TNNI3K_Spur TIPKSIVNILQMMWSPNPEERPTFAQ-----------------I AqueK135_Aque -------------------------------------------L AqueK499_Aque K-EKELFPLAKQCLNDVPSDRPEMINSCEF----------VEQV AqueK622_Aque -------------------------------------------E AqueK623_Aque -------------------------------------------P AqueK624_Aque -------------------------------------------T AqueK625_Aque -SSPQLYELIVLCINEEPDKRPTMSEII-------------LKL AqueK626_Aque -------------------------------------------D AqueK627_Aque -------------------------------------------D AqueK628_Aque -------------------------------------------E AqueK629_Aque -------------------------------------------P AqueK630_Aque -------------------------------------------P AqueK631_Aque -SWSDMKSLIQIGINASPRARLTMAQAK-------------SFM AqueK632_Aque K-ENELVPLAQKCLNDDPKYRPDMTELAQ-----------KLSK AqueK633_Aque -------------------------------------------P AqueK634_Aque -RRASFRSLVERCLIVEYRHRPTMNDIKTEL--------NDTVY AqueK635_Aque -------------------------------------------I AqueK636_Aque -------------------------------------------M AqueK637_Aque -------------------------------------------P AqueK638_Aque -------------------------------------------P AqueK639_Aque -------------------------------------------P AqueK640_Aque -------------------------------------------Q AqueK641_Aque -------------------------------------------G AqueK642_Aque EDEKDFLPLAKQCLQDNPSTRPDMSQVLQ-----------SVEE AqueK643_Aque -KRLALKNLIERCLMQNYKDRPTMSDII-------------KEL AqueK644_Aque -KRPTLKNLIECCLIENYKDRLAMSDII-------------KEL AqueK645_Aque -SWSDMKSLIQRGLKIDPRARPTMAQVL-------------ESL AqueK646_Aque -LEPSCKQMMARLWHADPSMRPTFKEFLV-----------KCEE AqueK647_Aque -KRPTLKNLIERCLIENYKDRPTIPVLVPGSELLSFQGYKTSWL AqueK648_Aque K-ENELLSLARDCLNDVPTDRPEMIE---------------SYP AqueK649_Aque R-EHPFRSLVERCLKDSPSRRPSAS-----------------EL