CLUSTAL W (1.83) multiple sequence alignment IRAK-Un_aw_Smoe ------------GSTFKGIL-SD--GVLVAVKKLERSSF----------------Q--SR IRAK-Un_co_Smoe ------------------------------------------------------------ IRAK-Un_ax_Smoe -------GRGGFASVYKGVI----DNHFVAVKYLTSSDL--------------SDK--AR IRAK-Un_br-2_Smoe ------------------------------------------------------------ IRAK-Un_bw_Smoe ------------------------------------------------------------ IRAK-Un_ca_Smoe ------------------------------------------------------------ IRAK-Un_am-2_Smoe FSKERLLGTGGFGEVYKGTL-DD--GVVVAIKLAKLGN----------------IK--GR IRAK-Un_da_Smoe FSERNIIGEGGYGIVYKGAV-S--DGTMVACKYLTNK-D----------------Q--AE IRAK-Un_dg_Smoe FS--NLIGQGSTNRVYKGIL-SD--GMEVAVKKLKQDVSE-------------CSD--VE IRAK-Un_dj_Smoe ----------------------------VVIKSVE------------------SR----- IRAK-Un_dm_Smoe EAIGIKIAEGGFGYVYRGTL-IN--RQEVAIKVRSSTS----------------SQ--GL IRAK-Un_ag_Smoe YAVLDPIGSGAYSDVYHGKRRDD--GLHVALKEVHDGK-S-------------SSR---- IRAK-Un_dq_Smoe YAVLDPIGSGAYSDVYHGKRRDD--GLHVALKEVHDGK-S-------------SSR---- IRAK-Un_dh_Smoe FSK--CLGQGGYGSVYRGSL-ED--GNQVAVKKLQGS-----------------NQ--TS IRAK-Un_dp_Smoe FSENRRLGDGGFGTVYAGTL-GG-GGDVVAVKLLHRSP----------------QQ--AS IRAK-Un_bk-2_Smoe FNPVNLIKAGHTGDLYRGIL-DG--GLLVVVKRVDVTS-L-------------KK----- IRAK-Un_bk-1_Smoe FNPVNLIKAGHTGDLYRGIL-DG--GLLVVVKRVDVTS-L-------------KK----- IRAK-Un_ck_Smoe FNETNKIGQGGYGSVYYGYF-RD---QKLAVKRMNM-------------------Q--AT IRAK-Un_cn_Smoe ------------GNVFRGTL-QD--GRVVVIKKKVS------------------------ IRAK-Un_bg_Smoe FSKECEVGCGGFGRVYRGNL-ED--GRTVAIKQASAKS----------------KQ--GQ IRAK-Un_cj_Smoe FNETNKIGQGGYGSVYYGYF-RD---QKLAVKRMNM-------------------Q--AT IRAK-Un_v-2_Smoe FSPAQMLGHGGHGTVYKGKL-PD--GRDVAVKRINHIS----------------SH--GI IRAK-Un_de_Smoe FT--TLVGSGAFGPVYKATP-SPSSPTRLAVKVLSSTS----------------KQ--GE IRAK-Un_dk_Smoe FDDSHLLGKGGFGAVYDAVL-P--DGSHLAVKRLRNEN----------------VA--ND IRAK-Un_bv_Smoe PPEHNLLGTGGFGKVYRGIL-PG-ENSPVAIKKMVRDS----------------HQ--GE IRAK-Un_ay-2_Smoe ------------------------DSHVVAVKYLTSSDL--------------SEK--AR IRAK-Un_ay-1_Smoe ------------------------DSHVVAVKYLTSSDL--------------SEK--AR IRAK-Un_df_Smoe FSENNKIGEGSYGHVYKGTL-HR---TNVAVKVLRHDS----------------WQ--GP IRAK-Un_bt_Smoe ------------------------------------------------------------ IRAK-Un_r_Smoe ------------------------------------------------------------ IRAK-Un_bb_Smoe ------------------------DGSEVAVKQLDLHS----------------KQ--GQ IRAK-Un_v-1_Smoe FSPAQMLGHGGHGTVYKGKL-PD--GRDVAVKRINHIS----------------SH--GI IRAK-Un_bx-1_Smoe FSDSHKLGQGGFGSVFKGTL-KN--GQHIAVKKLDTAS----------------LQ--GE LRR10a_d-2_Smoe FSRDAVIAMSRTGVFYKATL-RD--GSVLAVKKLRRAAM--------------HSA--GE IRAK-Un_cz_Smoe ------------GSTFKGIL-SD--GVLVAVKKLERSSF----------------Q--SR IRAK-Un_e_Smoe ----------------------------VAIKRSKSSA----------------NFGVMD IRAK-Un_dn_Smoe FSEENQLGQGGFGVVYKANL-K--DGTQVAVKKLSLHS----------------KQ--GK IRAK-Un_do_Smoe FHSLIGQGRGAASAVYRAKF-KD--GLVAAVKRFHAAP---------------QPQ--SE IRAK-Un_br-1_Smoe ------------------------------------------------------------ IRAK-Un_av-2_Smoe --------------VYKGRL-DQ--NRWIAVKKFPKTAWP------------------DA IRAK-Un_av-1_Smoe --------------VYKGRL-DQ--NRWIAVKKFPKTAWP------------------DA IRAK-Un_bx-2_Smoe FSDSHKLGQGGFGSVFKGTL-KN--GQHIAVKKLDTAS----------------LQ--GE IRAK-Un_am-1_Smoe FSKERLLGTGGFGEVYKGTL-DD--GVVVAIKLAKLGN----------------IK--GR IRAK-Un_bj-2_Smoe ------------------------------------------------------------ IRAK-Un_bj-1_Smoe ------------------------------------------------------------ RKF3_a-2_Smoe FSSKNFIGEGGYGRVYRGVL-AKRGNSEVAVKVMKASS----------------KE--NN IRAK-Un_bo-2_Smoe FNPSNLIGRGRFGLVYKGLL-ED--GTIVAIKTRAS-------------------A--PT IRAK-Un_dc_Smoe FSENNKIGEGSYGHVYKGTL-HR---TNVAVKVLRHDS----------------WQ--GP IRAK-Un_k-2_Smoe FSISNKIGEGGYGAVYYGEI-RD---QKLAIKKMNM-------------------Q--AT IRAK-Un_bo-1_Smoe FNPSNLIGRGRFGLVYKGLL-ED--GTIVAIKTRAS-------------------A--PT IRAK-Un_cb_Smoe YRIVGVLGSGGVGVTYEAET-EQ--GDAVAIKAMSLRNMK-------------GWK--DL IRAK-Un_cs_Smoe ------------------------------------------------------------ IRAK-Un_cu_Smoe FSSSNFIKAGHSGDLYRGVL-DG--GVLVVVKRIEVAK-M-------------KK----- IRAK-Un_t_Smoe FSSSNFIKAGHSGDLYRGVL-DG--GVLVVVKRIEVAK-M-------------KK----- IRAK-Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bp-1_Smoe FAPENKLGQGGFGSVYKGVL-P--NGTIVAMKELSSKS----------------NQ--GT IRAK-Un_bp-2_Smoe FAPENKLGQGGFGSVYKGVL-P--NGTIVAMKELSSKS----------------NQ--GT IRAK-Un_k-1_Smoe FSISKKIGEGGYGAVYYGEI-RD---QKLAIKKMNM-------------------Q--AT IRAK-Un_bd_Smoe FSK--CLGQGGYGSVYRGSL-ED--GNQVAVKKLQGS-----------------NQ--NS IRAK-Un_h_Smoe FQQMPLLGAGGAGKVYKAVL-E--GGMEVAVKRIPIQPPEPPSSSDASRSSGKGSF--GK IRAK_Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bf_Smoe FHAANKLGEGGSAVVYKGII-Q--TIGPVAIKFLQIKAH---------------SI--SN IRAK-Un_ap-1_Smoe FHKDNLVGRGGFASVYKGVI----DNHFVAVKYLTSSDL--------------SDK--AR IRAK-Un_ap-2_Smoe FHKDNLVGRGGFASVYKGVI----DNHFVAVKYLTSSDL--------------SDK--AR IRAK-Un_aw_Smoe KEFLAEM------------------NRIARLR-HP----SLV------------------ IRAK-Un_co_Smoe ------------------------------------------------------------ IRAK-Un_ax_Smoe RDFENEV------------------STICLLQ-HK----NVV------------------ IRAK-Un_br-2_Smoe ------------------------------------------------------------ IRAK-Un_bw_Smoe -----------------------------SVR-HQ----NLV------------------ IRAK-Un_ca_Smoe ------------------------------------------------------------ IRAK-Un_am-2_Smoe DQVINEV------------------RVLSQVN-HR----NLV------------------ IRAK-Un_da_Smoe KEFLVEV------------------ETIGRVR-HK----NLV------------------ IRAK-Un_dg_Smoe ASFRFQM------------------ELLSRVH-HQ----HLA------------------ IRAK-Un_dj_Smoe EMFDAEV------------------AMLAGLG-HSSSANRFV------------------ IRAK-Un_dm_Smoe REFTAEL------------------TLLSKIR-HP----NLV------------------ IRAK-Un_ag_Smoe -EL-AAL------------------QLLTNS---S----HVV------------------ IRAK-Un_dq_Smoe -EL-AAL------------------QLLTNS---S----HVV------------------ IRAK-Un_dh_Smoe RDFYAEL------------------ASLARTN-HL----NLV------------------ IRAK-Un_dp_Smoe PQFMAEI------------------DILSRFK-HP----NLV------------------ IRAK-Un_bk-2_Smoe DFLLSEL------------------EFFSKAS-HT----RLV------------------ IRAK-Un_bk-1_Smoe DFLLSEL------------------EFFSKAS-HT----RLV------------------ IRAK-Un_ck_Smoe KEFLSEL------------------KILSRVH-HS----NLVFSQALYFQLTPTIIFLLQ IRAK-Un_cn_Smoe ---ELEL------------------DILLRIR-SA----SIV------------------ IRAK-Un_bg_Smoe REFRNEI------------------QLLSRLH-HR----HLV------------------ IRAK-Un_cj_Smoe KEFLSEL------------------KILSRVH-HS----NLVFSQALYFQLTPTIIFLLQ IRAK-Un_v-2_Smoe EQVLNEV------------------KVLLSVS-HP----NLV------------------ IRAK-Un_de_Smoe REFQTEV------------------SLLGRLH-HK----NLV------------------ IRAK-Un_dk_Smoe PSFEAEI------------------STLGLIK-HR----NLV------------------ IRAK-Un_bv_Smoe REFLAEL------------------QIISKRS-HR----NLV------------------ IRAK-Un_ay-2_Smoe LDFENEV------------------STICLLQ-HK----NVV------------------ IRAK-Un_ay-1_Smoe LDFENEV------------------STISLLQ-HK----NVV------------------ IRAK-Un_df_Smoe QEFEQEVRKLTRISKISNEHGKIKVEVLSRLH-HP----HIV------------------ IRAK-Un_bt_Smoe ------------------------------------------------------------ IRAK-Un_r_Smoe KSLVKEL------------------SLLARLH-HA----YLV------------------ IRAK-Un_bb_Smoe REFVNEL------------------SIITSIQ-HK----NLA------------------ IRAK-Un_v-1_Smoe EQVLNEV------------------KVLLSVS-HP----NLV------------------ IRAK-Un_bx-1_Smoe REFMNEL------------------SIMGSMASSP----FVV------------------ LRR10a_d-2_Smoe KHFRSEM------------------EALAKVR-HR----NLV------------------ IRAK-Un_cz_Smoe KEFLAEM------------------NRIARLR-HP----SLV------------------ IRAK-Un_e_Smoe EQFLNEI------------------TILSQVN-HR----NLV------------------ IRAK-Un_dn_Smoe QEFVNEL------------------NIITGIR-HR----NLA------------------ IRAK-Un_do_Smoe EEFKNEA------------------HFLGRLH-HR----HLV------------------ IRAK-Un_br-1_Smoe ------------------------------------------------------------ IRAK-Un_av-2_Smoe RQFMDEA------------------FGVGQVR-HE----RLV------------------ IRAK-Un_av-1_Smoe RQFMDEA------------------FGVGQVR-HE----RLV------------------ IRAK-Un_bx-2_Smoe REFMNEL------------------SIMGSMASSP----FVV------------------ IRAK-Un_am-1_Smoe DQVINEV------------------RVLSQVN-HR----NLV------------------ IRAK-Un_bj-2_Smoe ------------------------------LK-HD----NLV------------------ IRAK-Un_bj-1_Smoe ------------------------------LK-HD----NLV------------------ RKF3_a-2_Smoe AEFLNEV------------------EVINRVR-HR----NLL------------------ IRAK-Un_bo-2_Smoe QEFVTEV------------------VNLSQLR-HK----NVV------------------ IRAK-Un_dc_Smoe QEFEQEVRKLTRISKISNKHGKIKVEVLSRLH-HP----HIV------------------ IRAK-Un_k-2_Smoe REFMSEL------------------KVLTHVH-HT----NLV------------------ IRAK-Un_bo-1_Smoe QEFVTEV------------------VNLSQLR-HK----NVV------------------ IRAK-Un_cb_Smoe DLFEREA------------------RVLKSLQ-HS----GIP------------------ IRAK-Un_cs_Smoe -------------------------------P-HP----NIV------------------ IRAK-Un_cu_Smoe DLLTLEL------------------EVFGKAS-HT----RLV------------------ IRAK-Un_t_Smoe DLLTLEL------------------EVFGKAS-HT----RLV------------------ IRAK-Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bp-1_Smoe REFLNEV------------------TVISAVQ-HR----NLV------------------ IRAK-Un_bp-2_Smoe REFLNEV------------------TVISAVQ-HR----NLV------------------ IRAK-Un_k-1_Smoe REFMSEL------------------KVLTHVH-HT----NLV------------------ IRAK-Un_bd_Smoe RDFYAEV------------------ASLARTN-HL----NLV------------------ IRAK-Un_h_Smoe RHTVAEM------------------ETLGKIR-HV----NLA------------------ IRAK_Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bf_Smoe EEFINEV------------------STISYLQ-HK----NLI------------------ IRAK-Un_ap-1_Smoe RDFENEV------------------SAICLLQ-HK----NVV------------------ IRAK-Un_ap-2_Smoe RDFENEV------------------STICLLQ-HK----NVV------------------ IRAK-Un_aw_Smoe -AVIGCCYD-H-----------------GERYIAYEYIANGPLDLWLHDPV--------- IRAK-Un_co_Smoe ------------------------------------------------------------ IRAK-Un_ax_Smoe -KLFGFCSE-K-----------------EHKLIVCEFIENGNLSEALFSSPD-------- IRAK-Un_br-2_Smoe ------------------------------------------------------------ IRAK-Un_bw_Smoe -KLQGYGAH-G-----------------QHYYRVCG--ISGSLLR---SM---------- IRAK-Un_ca_Smoe ------------------------------------------------------------ IRAK-Un_am-2_Smoe -RIWGCCVD-TG-----------------EPLVVYEYIPNGTLYEWLHVG--R------- IRAK-Un_da_Smoe -KLLGFCAE-G-----------------DHRILVYEYVNNGNLDEWLHGKTS-------- IRAK-Un_dg_Smoe -NLVGICDE-K-----------------QERMLLFQYAPNGTLFENLHTG---------- IRAK-Un_dj_Smoe -QIIGICSS-SSAGGGGGGGGDCADGHAQRMLLVLRQMPNGDLASALRRGDEFK---SSD IRAK-Un_dm_Smoe -PLLGYCTE-GQ-----------------HEMLVYPYMSNGTLQDRLYGE--A------- IRAK-Un_ag_Smoe -QLLDHVW------------------LHPGVLLVLEFL-PGSLAEVIEERKE-------- IRAK-Un_dq_Smoe -QLLDHVW------------------LHPGVLLVLEFL-PGSLAEVIEERKE-------- IRAK-Un_dh_Smoe -KFIGFCAE-GP----------------RKRLLVYEFVANGSLEKWIFVDGGGDDDSS-- IRAK-Un_dp_Smoe -QLLGCSTD-GQ-----------------SLLLVYEFVGNGTLADHLHTK--K------- IRAK-Un_bk-2_Smoe -PLLGHCLE-R----------------ENEKFLVYKYMQHGDLARALHRKIVPS------ IRAK-Un_bk-1_Smoe -PLLGHCLE-R----------------ENEKFLVYKYMQHGDLARALHRKIVPS------ IRAK-Un_ck_Smoe VQLIGYCTV--E-----------------SLFLVYEFVDNGTLAQHLHST---------- IRAK-Un_cn_Smoe -NLVGFSSD-A-----------------QQKCLVFDYMHLGRLSRRLFDD---------- IRAK-Un_bg_Smoe -RLLGFCQS-GK-----------------NQ----------------------------- IRAK-Un_cj_Smoe VQLIGYCTV--E-----------------SLFLVYEFVDNGTLAQHLHSA---------- IRAK-Un_v-2_Smoe -QLLGCCLE-VY-----------------DPLLVYEFVPNGTLAEHLQRE--R------- IRAK-Un_de_Smoe -NLVGYCTD-RR-----------------ERMLVYEYMSNGSLEKLLYND--K------- IRAK-Un_dk_Smoe -SLKGFYCS-A-----------------QEKLLFYDYMPCGSLHDVLHGGGVA------- IRAK-Un_bv_Smoe -PLRGWHCA-RD---------------HRELVLVYDYMPQGSVESALFHKGD-------- IRAK-Un_ay-2_Smoe -RLFGFCSE-K-----------------EHKLIVCELVENGNLSDALFELLTRV---S-- IRAK-Un_ay-1_Smoe -KLFGFCSE-K-----------------EHKLIVCELVENGNLSDALFEIMKRV---S-- IRAK-Un_df_Smoe -LLLGGNP---E-----------------KKCLVYEYLENGSLEDRLFCK---------- IRAK-Un_bt_Smoe ------------------------------------------------------------ IRAK-Un_r_Smoe -NLVGYCAQ--------------------EQLLAFEFMENGSLFDCLFKK--P------- IRAK-Un_bb_Smoe -KLRGYCLD-R-----------------DDRILVYEFLENKSLDQLLFESAT-------- IRAK-Un_v-1_Smoe -QLLGCCLE-VY-----------------DPLLVYEFVPNGTLAEHLQRE--R------- IRAK-Un_bx-1_Smoe -GLIGFCAE-T-----------------KRKMLVYEFMANRSLQEVLFDE---------- LRR10a_d-2_Smoe -PLLGYCIA-G-----------------NERLLVYKHMPCGNLYNRLHTAAAST---P-- IRAK-Un_cz_Smoe -AVIGCCYD-H-----------------GERYIAYEYIANGPLDLWLHDPV--------- IRAK-Un_e_Smoe -KLKGWCMD-TR-------------R-NAPPLLVYEYVTNGTLLEHLQCK--R------- IRAK-Un_dn_Smoe -MLHGYCVE-A-----------------NERLLVYEFLENGSLDSALFQSS--------- IRAK-Un_do_Smoe -SLRGFCMR-KN-----------------ERFLVYDFMENGSLKERLHLHHRG------- IRAK-Un_br-1_Smoe ------------------------------------------------------------ IRAK-Un_av-2_Smoe -NLIGCCCE-G-----------------DERLLVAEYMPNDTLTKHLFHW---------- IRAK-Un_av-1_Smoe -NLIGCCCE-G-----------------DERLLVAEYMPNDTLTKHLFHW---------- IRAK-Un_bx-2_Smoe -GLIGFCAD-S-----------------KRKMLVYEFMANRSLQEILFDE---------- IRAK-Un_am-1_Smoe -RIWGCCVD-TG-----------------EPLVVYEYIPNGTLYEWLHVG--R------- IRAK-Un_bj-2_Smoe -KLKGFCCVQG----------------GLQCYLVYDFVPNGSLFEHLHGPS--------- IRAK-Un_bj-1_Smoe -KLKGFCCVQG----------------GLQCYLVYDFVPNGSLFEHLHGPS--------- RKF3_a-2_Smoe -SVRGACVH-AN-------------GPDSQHILVYDYMPNGCLKTYLSS----------- IRAK-Un_bo-2_Smoe -SLLGFCQE-H-----------------DHQMLVYDYLPNGSVSSHLCDPNG-------- IRAK-Un_dc_Smoe -LLLGGNP---E-----------------KKCLVYEYLENGSLEDRLFCK---------- IRAK-Un_k-2_Smoe -QLIGYCTV--D-----------------SLFLVYEYVDNGTLSHHLRGS---------- IRAK-Un_bo-1_Smoe -SLLGFCQE-H-----------------DHQMLVYDYLPNGSVSSHLCDPNG-------- IRAK-Un_cb_Smoe -EYIDFFEI-EN--------------EKDKGFYIVQKVAKGKSLAKLVEEGW-------- IRAK-Un_cs_Smoe -RLLGFCTS-P-----------------FLHALVMPLEKRGCLKGMVLD----------- IRAK-Un_cu_Smoe -PLLGHCLE-M----------------DELKFLVYKYMPNGDLGQALHKKVVPS------ IRAK-Un_t_Smoe -PLLGHCLE-M----------------DELKFLVYKYMPNGDLGQALHKKVVPS------ IRAK-Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bp-1_Smoe -KLHGCCIE-G-----------------SHRILIYEFLENNSLHQALLKPKE-------- IRAK-Un_bp-2_Smoe -KLHGCCIE-G-----------------SHRILIYEFLENNSLHQALLKPKE-------- IRAK-Un_k-1_Smoe -QLIGYCTV--D-----------------SLFLVYEYVDNGTLSHHLRGS---------- IRAK-Un_bd_Smoe -KFIGFCAE-GP----------------RKRLLVYEFVPNGSLEKWIFGDDGGD-DSS-- IRAK-Un_h_Smoe -WLYAYILK-P-----------------DAHLLLYQYMPRGSLQDVLARVRD-------- IRAK_Un_dd_Smoe -----------------------------------EFVPNGTLAEHLQRE--R------- IRAK-Un_bf_Smoe -RLVGFCCE-G-----------------EHRLLVYEFLENNSLALAILSGPN-------- IRAK-Un_ap-1_Smoe -KLFGFCSE-K-----------------EHKLIVCEFIENGNLSDALFRSPD-------- IRAK-Un_ap-2_Smoe -KLFGFCSE-K-----------------EHKLTVCEFIENGNLSDALFRSPD-------- IRAK-Un_aw_Smoe -------------RRGTLD-WRTRMQIAVTAAQGIAYLHDQV-KPHVIHRDIKASSILLD IRAK-Un_co_Smoe -------------------------------------------SPPIYHRDVKSSNILLD IRAK-Un_ax_Smoe -------------KGLELN-WTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLA IRAK-Un_br-2_Smoe ------------------------------------------------------------ IRAK-Un_bw_Smoe -------------KQQALR-WERRWRIAADIARGLDYLHGGC-KDQVLHLDIKPQNILLD IRAK-Un_ca_Smoe ----------------------------REIARGICFLHEEC-STRVLHLAINPQNTLLA IRAK-Un_am-2_Smoe ---------------GFLD-WRSRLRIALQTAEGLAYLHSAA-YPPIYHRDVKSSNILLD IRAK-Un_da_Smoe -------------RFKTPS-WDSRMKIILGTAKGLAYMHEAI-EPKIVHRDIKASNILLD IRAK-Un_dg_Smoe --------------DENLS-WKQRMRIIVGAAYGLAYLHHLC-NPPVIHGDLRSRNILLT IRAK-Un_dj_Smoe GETSESSDSSSAGSAKPLD-WITRFKIAIGVAEALAFLHHDC-SPAVIHRDLKSSSVFLD IRAK-Un_dm_Smoe ------------ATRKPLD-WQTRLSIAIGAARGLNFLHTSG-PRPIIHRDVKSSNILLD IRAK-Un_ag_Smoe ---------------IPFQEFEAR-NWMEQILKAVAECH----SAGILHRDLKPSNLLIS IRAK-Un_dq_Smoe ---------------IPFQEFEAR-NWMEQILKAVAECH----SAGILHRDLKPSNLLIS IRAK-Un_dh_Smoe --------SQQQDGSGGLS-WDFKFRIAVGTAQGLCYLHEEC-AEKIIHLDLKPENVLVD IRAK-Un_dp_Smoe ---------------SRLP-WLTRLAIAIDIAQVLAYLHSY----SILHRDVKSTNVLLD IRAK-Un_bk-2_Smoe ---------PPKDILQSLD-WITRLKIAIGAAEGLSYLHHEC-SPALVHRDIKATSILLD IRAK-Un_bk-1_Smoe ---------PPKDILQSLD-WITRLKIAIGAAEGLSYLHHEC-SPALVHRDIKATSILLD IRAK-Un_ck_Smoe -------------TRPPLS-WSSRIQIAMDAARGLEYIHEHA-KPTYIHRDIKSTNILID IRAK-Un_cn_Smoe -------------TLPPIS-WGNRLRIALQISRAVEYLHTYA-EPHIVHLNISAENVLLD IRAK-Un_bg_Smoe ------------------------------------------------------------ IRAK-Un_cj_Smoe -------------TRPPLS-WSSRIQIAMDAARGLEYIHEHT-KPTYIHRDIKSTNILID IRAK-Un_v-2_Smoe --------------GDGLD-WFTRVAIAAEAAQGIAYLHSRS--PPIYHRDVKSTNILLD IRAK-Un_de_Smoe --------------REALS-WSERVQIAKDVSRGIEYLHDGA-VPPVIHRDIKSANILLD IRAK-Un_dk_Smoe ----------SASPSTLLS-WMARLRIAVGTARGLLYLHEGC-SPRIIHRDVKSSNILLD IRAK-Un_bv_Smoe --------------ALLLL-WDARLRILSGLAAALIYLHEDW-EQQVIHRDVKCSNVMLD IRAK-Un_ay-2_Smoe --------SISVRNDLQLD-WTARYNICVGVAQGLAYLHGETSQVTIVHRDIKALNILLA IRAK-Un_ay-1_Smoe --------SISVWKDLQLD-WTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLA IRAK-Un_df_Smoe ------------DDSPPIS-CLTRYQIAVEVGTALLFLHKAK-PQPIVLRDLKPSNILLD IRAK-Un_bt_Smoe --------------------------------RGLKYLHEIV-SPLIIHRDFKSSNILLA IRAK-Un_r_Smoe --------------EIRLD-WFLRIRIAAQAARGLEYLHIYA-SPQILHRDVKAANILLD IRAK-Un_bb_Smoe --------------GIFLD-WPTRFQIVLGVANGLAYLHEGS-QKQIIHRDIKASNILLD IRAK-Un_v-1_Smoe --------------GDGLD-WFTRVAIAAEAAQGIAYLHSRS--PPIYHRDVKSTNILLD IRAK-Un_bx-1_Smoe ------------KHSVVLQ-WERRAKIVADVARALAFLHGKC-EPPIVHGDVKPSNVLLG LRR10a_d-2_Smoe ------GDSSSGSTSGRLD-WAARLKVAVGTARGLAWLHHSC-NPRLVHKGITSASILLD IRAK-Un_cz_Smoe -------------RRGTLD-WRTRMQIAVTAAQGIAYLHDQV-KPHVIHRDIKASSILLD IRAK-Un_e_Smoe -------------GVVPLG-WEQRLQIVIETAEALAYLHSVA-APPIYHRDVKSSNILLD IRAK-Un_dn_Smoe ---------------SALN-WQSRFQITIGIARGLAYLHEES-HFQIIHRDIKASNVLLD IRAK-Un_do_Smoe ------------RSNGTLS-WQRRLQIAIEVATGMEYVHCYC-EPPLCHGNLKSSNILLD IRAK-Un_br-1_Smoe ------------------------------------------------------------ IRAK-Un_av-2_Smoe -------------EKQPMQ-WSMRLRVALYIAQALEHCSN---NNRRLYHDLNAYRVLFD IRAK-Un_av-1_Smoe -------------EKQPMQ-WSMRLRVALYIAQALEHCSN---NNRRLYHDLNAYRVLFD IRAK-Un_bx-2_Smoe ------------KHSVVLQ-WERRAKIVADVARALAFLHGKC-EPPIVHGDVKPSNVLLG IRAK-Un_am-1_Smoe ---------------GFLD-WRSRLRIALQTAEGLAYLHSAA-YPPIYHRDVKSSNILLD IRAK-Un_bj-2_Smoe --------------VSPLD-WGTRVQIAHGVAKGLDYLHRNG-EQVI----VWASNVLLD IRAK-Un_bj-1_Smoe --------------VSPLD-WGTRVQIAHGVAKGLDYLHRNG-EQVI----VWASNVLLD RKF3_a-2_Smoe ---------------GTLS-WQQRRKIAIGIAVGINYLHNEV-EPSIIHRDIKPSNILLD IRAK-Un_bo-2_Smoe ------------NPTGELD-FKQRVAIALGAARGLEYLHSGN--PPRVHQDFKTSNVLLD IRAK-Un_dc_Smoe ------------DDSPPIS-CLTRYQIAVEVGTALLFLHKAK-PQPIVLRDLKPSNILLD IRAK-Un_k-2_Smoe -------------APSRLT-WNQRIQIALDAARGLEYIHEHT-KPTYIHRDVKSPNILID IRAK-Un_bo-1_Smoe ------------NPTGELD-FKQRVAIALGAARGLEYLHSGN--PPRVHQDFKTSNVLLD IRAK-Un_cb_Smoe ----------------RVS-EQEVKDIAIEILDVLKYLGS-L-RPPVIHRDIKPDNIILD IRAK-Un_cs_Smoe ---------------GSLG-WKQRVKIIKGLALALDHLH--------------------- IRAK-Un_cu_Smoe ---------PPADILQSLD-WITRLKIAIGVAEGLSYLHHEC-VPPLVHRDVQASSILLD IRAK-Un_t_Smoe ---------PPADILQSLD-WITRLKIAIGVAEGLSYLHHEC-VPPLVHRDVQASSILLD IRAK-Un_dd_Smoe ----------------------------------------------IIRRDLRPHNILLT IRAK-Un_bp-1_Smoe -------------RVIHFD-WPTRFNICVGIARGIAYLHEES-LPRIVHRDIKASNVLLD IRAK-Un_bp-2_Smoe -------------RVIHFD-WPTRFNICVGIARGIAYLHEES-LPRIVHRDIKASNVLLD IRAK-Un_k-1_Smoe -------------APSRLT-WNQRIQIALDAARGLEYIHEHT-KPTYIHRDVKSPNILID IRAK-Un_bd_Smoe --------SQQQDGSGGLS-WDCKFRIAVGTAQGLCYLHEEC-ADRIIHLDLKPENVLVD IRAK-Un_h_Smoe -------------GAMELE-WSARQRIATGMVRGLKYLHYDC-SPKILHRDLKTSNILLD IRAK_Un_dd_Smoe --------------GDGLD-WFTRVAIAADAAQGIAYLHSRS--PPIYHRDVKSTNILLD IRAK-Un_bf_Smoe --------------KLYIP-WAKRYEICLGVARGIAYLHEES-RTRIVHRDIKASNILLD IRAK-Un_ap-1_Smoe -------------KGLELN-WTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLA IRAK-Un_ap-2_Smoe -------------KGLELN-WTARYNICVGVAQGLAYLHGETSQATIVHRDIKALSILLA IRAK-Un_aw_Smoe DKF--------------------HGRVMGVGLASVVPWEA---AYER------------- IRAK-Un_co_Smoe EKL--------------------TANVADFGISKVVPIDST------------------- IRAK-Un_ax_Smoe SNL--------------------EAKISDFGLARLIQEDR---SYIS------------- IRAK-Un_br-2_Smoe ------------------------------------------------------------ IRAK-Un_bw_Smoe ASF--------------------GAKICDFGLERVDHEK----NSVS------------- IRAK-Un_ca_Smoe ENF--------------------GVKIADVGLS--------------------------- IRAK-Un_am-2_Smoe NSL--------------------VARVCDFGLSRLAEPDL---SHVS------------- IRAK-Un_da_Smoe SHW--------------------NAKVSDFGLAKFLGCEK---THVM------------- IRAK-Un_dg_Smoe EDF--------------------AAKVWAMVVPIAGSSE-------L------------- IRAK-Un_dj_Smoe EGY--------------------EVRLGSF------------------------------ IRAK-Un_dm_Smoe DSM--------------------NARVADFGFSRFAPQE--DDSLVS------------- IRAK-Un_ag_Smoe SDG--------------------VLKVADFGTALVLPVEN---VEEALKS---------- IRAK-Un_dq_Smoe SDG--------------------VLKVADFGTALVLPVEN---VEEAVKDSSSGKKKLKG IRAK-Un_dh_Smoe IGF--------------------VPKIADFGLSKLMNREV---TYL-------------- IRAK-Un_dp_Smoe EGF--------------------HAKLGDFGLSKAAAAAAAVEGHVS------------- IRAK-Un_bk-2_Smoe DKF--------------------EVRL--------------------------------- IRAK-Un_bk-1_Smoe DKF--------------------EVRL--------------------------------- IRAK-Un_ck_Smoe KNF--------------------HAKVADFGLSKLTETGM---TSIS------------- IRAK-Un_cn_Smoe GSW--------------------NAKLSGFGR---------------------------- IRAK-Un_bg_Smoe ------------------------------------------------------------ IRAK-Un_cj_Smoe KNL--------------------HAKVADFGLSKLTETGM---TSIS------------- IRAK-Un_v-2_Smoe GEF--------------------NTKVGDFGLSRTALTEA---SHVS------------- IRAK-Un_de_Smoe NSM--------------------TARVADFGLSKEVS-P--V--VPT------------- IRAK-Un_dk_Smoe SDM--------------------EPHIADFGLARLVENNA---THLT------------- IRAK-Un_bv_Smoe EEF--------------------RARLGDFGLARTASHDV---SSRT------------- IRAK-Un_ay-2_Smoe SDL--------------------KPKISDFGLARLIQQSR---SYIS------------- IRAK-Un_ay-1_Smoe SDL--------------------KPKISDFGLARLIQQSR---SYTS------------- IRAK-Un_df_Smoe KNY--------------------NSKISDVGLARFMPGDE---TSVR------------- IRAK-Un_bt_Smoe DKF--------------------NTKVSDFGLAKLGLDKA-------------------- IRAK-Un_r_Smoe KDW--------------------NAHLSDFGFSLSPS-G--NTTQL-------------- IRAK-Un_bb_Smoe HKL--------------------HPKISDFEISKL------------------------- IRAK-Un_v-1_Smoe GEF--------------------NTKVGDFGLSRTALTEA---SHVS------------- IRAK-Un_bx-1_Smoe ADF--------------------GAKLADFGLARVKTQES---AAVD------------- LRR10a_d-2_Smoe EDL--------------------EPRITDFGLARLIVTGR---GRPG------------- IRAK-Un_cz_Smoe DKF--------------------HGRVMGVGLASVVPWEA---AYER------------- IRAK-Un_e_Smoe DSL--------------------SAKVADFGISKLVGTGDAATTHVS------------- IRAK-Un_dn_Smoe AKL--------------------QPKISDFGLSKLFDLDG---KHVV------------- IRAK-Un_do_Smoe ENF--------------------VAKV--------------------------------- IRAK-Un_br-1_Smoe ------------------------------------------------------------ IRAK-Un_av-2_Smoe QVLFNPFRSLLVYALTAAVLQDGDPRLSCFGLMKNSRDG--------------------- IRAK-Un_av-1_Smoe QVLFNPFRSLLVYALTAAVLQDGDPRLSCFGLMKNSRDG--------------------- IRAK-Un_bx-2_Smoe ADF--------------------GAKLADFGLARVKTQES---AAVD------------- IRAK-Un_am-1_Smoe NSL--------------------VARVCDFGLSRLAEPDL---SHVS------------- IRAK-Un_bj-2_Smoe ESY--------------------NALVSSWGHNKVLADEL---VYAN------------- IRAK-Un_bj-1_Smoe ESY--------------------NALVSSWGHNKVLADEL---VYAN------------- RKF3_a-2_Smoe EDL--------------------NARVADFGLAKISPEGM---SHLT------------- IRAK-Un_bo-2_Smoe ENL--------------------VAKVTDVGLSKLLVTSH---NAMP------------- IRAK-Un_dc_Smoe KNY--------------------NSKISDVGLARFM------------------------ IRAK-Un_k-2_Smoe KRL--------------------RAKVADFGLTKLTESGA---GSVS------------- IRAK-Un_bo-1_Smoe ENL--------------------VAKVTDVGLSKLLVTSH---NAMP------------- IRAK-Un_cb_Smoe EATG-------------------KVKVVDFGAVQDTTSSA---TF--------------- IRAK-Un_cs_Smoe ------------------------------------------------------------ IRAK-Un_cu_Smoe DKF--------------------EVRL--------------------------------- IRAK-Un_t_Smoe DKF--------------------EVRL--------------------------------- IRAK-Un_dd_Smoe HDY--------------------APMVGDFGLARWHT----------------------- IRAK-Un_bp-1_Smoe KTL--------------------NPKIADFGLAKLFKDHQ---THVS------------- IRAK-Un_bp-2_Smoe KTL--------------------NPKIADFGLAKLFKDHQ---THVS------------- IRAK-Un_k-1_Smoe KRL--------------------RAKVADFGLTKLTESGA---GSVS------------- IRAK-Un_bd_Smoe IGF--------------------VPKIADFGLSKLMNREV---TYL-------------- IRAK-Un_h_Smoe EEL--------------------EAHLGDFGLAKALPDGM---THVT------------- IRAK_Un_dd_Smoe D----------------------------------------------------------- IRAK-Un_bf_Smoe KEF--------------------NARVSDFGLARLLKDGD---THLS------------- IRAK-Un_ap-1_Smoe SNL--------------------EAKISDFGLARLIQEDR---SYIS------------- IRAK-Un_ap-2_Smoe SNL--------------------EAKISDFGLARLIQEDR---SYIN------------- IRAK-Un_aw_Smoe ------------------------------------------------------------ IRAK-Un_co_Smoe ------------------------------------------------------------ IRAK-Un_ax_Smoe ------------------------------------------------------------ IRAK-Un_br-2_Smoe ------------------------------------------------------------ IRAK-Un_bw_Smoe ------------------------------------------------------------ IRAK-Un_ca_Smoe ------------------------------------------------------------ IRAK-Un_am-2_Smoe ------------------------------------------------------------ IRAK-Un_da_Smoe ------------------------------------------------------------ IRAK-Un_dg_Smoe ------------------------------------------------------------ IRAK-Un_dj_Smoe ------------------------------------------------------------ IRAK-Un_dm_Smoe ------------------------------------------------------------ IRAK-Un_ag_Smoe -------------------------------AATSSEQQPETMVPAQIRGSKSYDRLEIE IRAK-Un_dq_Smoe GAEFDRFGSGKKLDSEEIEAWLQGGSFKLKSAATSSEQQPETMVPAQIRGSKSYDRLEIE IRAK-Un_dh_Smoe ------------------------------------------------------------ IRAK-Un_dp_Smoe ------------------------------------------------------------ IRAK-Un_bk-2_Smoe ------------------------------------------------------------ IRAK-Un_bk-1_Smoe ------------------------------------------------------------ IRAK-Un_ck_Smoe ------------------------------------------------------------ IRAK-Un_cn_Smoe ------------------------------------------------------------ IRAK-Un_bg_Smoe ------------------------------------------------------------ IRAK-Un_cj_Smoe ------------------------------------------------------------ IRAK-Un_v-2_Smoe ------------------------------------------------------------ IRAK-Un_de_Smoe ------------------------------------------------------------ IRAK-Un_dk_Smoe ------------------------------------------------------------ IRAK-Un_bv_Smoe ------------------------------------------------------------ IRAK-Un_ay-2_Smoe ------------------------------------------------------------ IRAK-Un_ay-1_Smoe ------------------------------------------------------------ IRAK-Un_df_Smoe ------------------------------------------------------------ IRAK-Un_bt_Smoe ------------------------------------------------------------ IRAK-Un_r_Smoe ------------------------------------------------------------ IRAK-Un_bb_Smoe ------------------------------------------------------------ IRAK-Un_v-1_Smoe ------------------------------------------------------------ IRAK-Un_bx-1_Smoe ------------------------------------------------------------ LRR10a_d-2_Smoe ------------------------------------------------------------ IRAK-Un_cz_Smoe ------------------------------------------------------------ IRAK-Un_e_Smoe ------------------------------------------------------------ IRAK-Un_dn_Smoe ------------------------------------------------------------ IRAK-Un_do_Smoe ------------------------------------------------------------ IRAK-Un_br-1_Smoe ------------------------------------------------------------ IRAK-Un_av-2_Smoe ------------------------------------------------------------ IRAK-Un_av-1_Smoe ------------------------------------------------------------ IRAK-Un_bx-2_Smoe ------------------------------------------------------------ IRAK-Un_am-1_Smoe ------------------------------------------------------------ IRAK-Un_bj-2_Smoe ------------------------------------------------------------ IRAK-Un_bj-1_Smoe ------------------------------------------------------------ RKF3_a-2_Smoe ------------------------------------------------------------ IRAK-Un_bo-2_Smoe ------------------------------------------------------------ IRAK-Un_dc_Smoe ------------------------------------------------------------ IRAK-Un_k-2_Smoe ------------------------------------------------------------ IRAK-Un_bo-1_Smoe ------------------------------------------------------------ IRAK-Un_cb_Smoe ------------------------------------------------------------ IRAK-Un_cs_Smoe ------------------------------------------------------------ IRAK-Un_cu_Smoe ------------------------------------------------------------ IRAK-Un_t_Smoe ------------------------------------------------------------ IRAK-Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bp-1_Smoe ------------------------------------------------------------ IRAK-Un_bp-2_Smoe ------------------------------------------------------------ IRAK-Un_k-1_Smoe ------------------------------------------------------------ IRAK-Un_bd_Smoe ------------------------------------------------------------ IRAK-Un_h_Smoe ------------------------------------------------------------ IRAK_Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bf_Smoe ------------------------------------------------------------ IRAK-Un_ap-1_Smoe ------------------------------------------------------------ IRAK-Un_ap-2_Smoe ------------------------------------------------------------ IRAK-Un_aw_Smoe ------------------------------------------------------------ IRAK-Un_co_Smoe ------------------------------------------------------------ IRAK-Un_ax_Smoe ------------------------------------------------------------ IRAK-Un_br-2_Smoe ------------------------------------------------------------ IRAK-Un_bw_Smoe ------------------------------------------------------------ IRAK-Un_ca_Smoe ------------------------------------------------------------ IRAK-Un_am-2_Smoe ------------------------------------------------------------ IRAK-Un_da_Smoe ------------------------------------------------------------ IRAK-Un_dg_Smoe ------------------------------------------------------------ IRAK-Un_dj_Smoe ------------------------------------------------------------ IRAK-Un_dm_Smoe ------------------------------------------------------------ IRAK-Un_ag_Smoe DSGT-------------------------------------------------------- IRAK-Un_dq_Smoe DSGT-------------------------------------------------------- IRAK-Un_dh_Smoe ------------------------------------------------------------ IRAK-Un_dp_Smoe ------------------------------------------------------------ IRAK-Un_bk-2_Smoe ------------------------------------------------------------ IRAK-Un_bk-1_Smoe ------------------------------------------------------------ IRAK-Un_ck_Smoe ------------------------------------------------------------ IRAK-Un_cn_Smoe ------------------------------------------------------------ IRAK-Un_bg_Smoe ------------------------------------------------------------ IRAK-Un_cj_Smoe ------------------------------------------------------------ IRAK-Un_v-2_Smoe ------------------------------------------------------------ IRAK-Un_de_Smoe ------------------------------------------------------------ IRAK-Un_dk_Smoe ------------------------------------------------------------ IRAK-Un_bv_Smoe ------------------------------------------------------------ IRAK-Un_ay-2_Smoe ------------------------------------------------------------ IRAK-Un_ay-1_Smoe ------------------------------------------------------------ IRAK-Un_df_Smoe ------------------------------------------------------------ IRAK-Un_bt_Smoe ------------------------------------------------------------ IRAK-Un_r_Smoe ------------------------------------------------------------ IRAK-Un_bb_Smoe ------------------------------------------------------------ IRAK-Un_v-1_Smoe ------------------------------------------------------------ IRAK-Un_bx-1_Smoe ---ERERNDDFGKLSRGGAATPSSIGGGQDDDEEWSKLSQSAYGTEADTWSKISPSEIDC LRR10a_d-2_Smoe ------------------------------------------------------------ IRAK-Un_cz_Smoe ------------------------------------------------------------ IRAK-Un_e_Smoe ------------------------------------------------------------ IRAK-Un_dn_Smoe ------------------------------------------------------------ IRAK-Un_do_Smoe ------------------------------------------------------------ IRAK-Un_br-1_Smoe ------------------------------------------------------------ IRAK-Un_av-2_Smoe ------------------------------------------------------------ IRAK-Un_av-1_Smoe ------------------------------------------------------------ IRAK-Un_bx-2_Smoe ---ERERNDDFGKVSRGGAATPSSIGGGQDDDEEWSKLSQSAYGTEADTWSKISPSEIDC IRAK-Un_am-1_Smoe ------------------------------------------------------------ IRAK-Un_bj-2_Smoe ------------------------------------------------------------ IRAK-Un_bj-1_Smoe ------------------------------------------------------------ RKF3_a-2_Smoe ------------------------------------------------------------ IRAK-Un_bo-2_Smoe ------------------------------------------------------------ IRAK-Un_dc_Smoe ------------------------------------------------------------ IRAK-Un_k-2_Smoe ------------------------------------------------------------ IRAK-Un_bo-1_Smoe ------------------------------------------------------------ IRAK-Un_cb_Smoe ------------------------------------------------------------ IRAK-Un_cs_Smoe ------------------------------------------------------------ IRAK-Un_cu_Smoe ------------------------------------------------------------ IRAK-Un_t_Smoe ------------------------------------------------------------ IRAK-Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bp-1_Smoe ------------------------------------------------------------ IRAK-Un_bp-2_Smoe ------------------------------------------------------------ IRAK-Un_k-1_Smoe ------------------------------------------------------------ IRAK-Un_bd_Smoe ------------------------------------------------------------ IRAK-Un_h_Smoe ------------------------------------------------------------ IRAK_Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bf_Smoe ------------------------------------------------------------ IRAK-Un_ap-1_Smoe ------------------------------------------------------------ IRAK-Un_ap-2_Smoe ------------------------------------------------------------ IRAK-Un_aw_Smoe ------------------------------------------------------------ IRAK-Un_co_Smoe ------------------------------------------------------------ IRAK-Un_ax_Smoe ------------------------------------------------------------ IRAK-Un_br-2_Smoe ------------------------------------------------------------ IRAK-Un_bw_Smoe ------------------------------------------------------------ IRAK-Un_ca_Smoe ------------------------------------------------------------ IRAK-Un_am-2_Smoe ------------------------------------------------------------ IRAK-Un_da_Smoe ------------------------------------------------------------ IRAK-Un_dg_Smoe ------------------------------------------------------------ IRAK-Un_dj_Smoe ------------------------------------------------------------ IRAK-Un_dm_Smoe ------------------------------------------------------------ IRAK-Un_ag_Smoe ------------------------------------------------------------ IRAK-Un_dq_Smoe ------------------------------------------------------------ IRAK-Un_dh_Smoe ------------------------------------------------------------ IRAK-Un_dp_Smoe ------------------------------------------------------------ IRAK-Un_bk-2_Smoe ------------------------------------------------------------ IRAK-Un_bk-1_Smoe ------------------------------------------------------------ IRAK-Un_ck_Smoe ------------------------------------------------------------ IRAK-Un_cn_Smoe ------------------------------------------------------------ IRAK-Un_bg_Smoe ------------------------------------------------------------ IRAK-Un_cj_Smoe ------------------------------------------------------------ IRAK-Un_v-2_Smoe ------------------------------------------------------------ IRAK-Un_de_Smoe ------------------------------------------------------------ IRAK-Un_dk_Smoe ------------------------------------------------------------ IRAK-Un_bv_Smoe ------------------------------------------------------------ IRAK-Un_ay-2_Smoe ------------------------------------------------------------ IRAK-Un_ay-1_Smoe ------------------------------------------------------------ IRAK-Un_df_Smoe ------------------------------------------------------------ IRAK-Un_bt_Smoe ------------------------------------------------------------ IRAK-Un_r_Smoe ------------------------------------------------------------ IRAK-Un_bb_Smoe ------------------------------------------------------------ IRAK-Un_v-1_Smoe ------------------------------------------------------------ IRAK-Un_bx-1_Smoe RSEISFDGTGQGQAGIKNFLGRKKPWGQRKASASPSSGNGKNSNNGSRDWWWKQESSGQQ LRR10a_d-2_Smoe ------------------------------------------------------------ IRAK-Un_cz_Smoe ------------------------------------------------------------ IRAK-Un_e_Smoe ------------------------------------------------------------ IRAK-Un_dn_Smoe ------------------------------------------------------------ IRAK-Un_do_Smoe ------------------------------------------------------------ IRAK-Un_br-1_Smoe ------------------------------------------------------------ IRAK-Un_av-2_Smoe ------------------------------------------------------------ IRAK-Un_av-1_Smoe ------------------------------------------------------------ IRAK-Un_bx-2_Smoe RSEISFDGTGQGQAGIKNFLGRKKPWGQRKASASPSSGNGKNTNNGSRDWWWKQESSGQQ IRAK-Un_am-1_Smoe ------------------------------------------------------------ IRAK-Un_bj-2_Smoe ------------------------------------------------------------ IRAK-Un_bj-1_Smoe ------------------------------------------------------------ RKF3_a-2_Smoe ------------------------------------------------------------ IRAK-Un_bo-2_Smoe ------------------------------------------------------------ IRAK-Un_dc_Smoe ------------------------------------------------------------ IRAK-Un_k-2_Smoe ------------------------------------------------------------ IRAK-Un_bo-1_Smoe ------------------------------------------------------------ IRAK-Un_cb_Smoe ------------------------------------------------------------ IRAK-Un_cs_Smoe ------------------------------------------------------------ IRAK-Un_cu_Smoe ------------------------------------------------------------ IRAK-Un_t_Smoe ------------------------------------------------------------ IRAK-Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bp-1_Smoe ------------------------------------------------------------ IRAK-Un_bp-2_Smoe ------------------------------------------------------------ IRAK-Un_k-1_Smoe ------------------------------------------------------------ IRAK-Un_bd_Smoe ------------------------------------------------------------ IRAK-Un_h_Smoe ------------------------------------------------------------ IRAK_Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bf_Smoe ------------------------------------------------------------ IRAK-Un_ap-1_Smoe ------------------------------------------------------------ IRAK-Un_ap-2_Smoe ------------------------------------------------------------ IRAK-Un_aw_Smoe ------------------------------------------------------------ IRAK-Un_co_Smoe ------------------------------------------------------------ IRAK-Un_ax_Smoe ------------------------------------------------------------ IRAK-Un_br-2_Smoe ------------------------------------------------------------ IRAK-Un_bw_Smoe ------------------------------------------------------------ IRAK-Un_ca_Smoe ------------------------------------------------------------ IRAK-Un_am-2_Smoe ------------------------------------------------------------ IRAK-Un_da_Smoe ------------------------------------------------------------ IRAK-Un_dg_Smoe ------------------------------------------------------------ IRAK-Un_dj_Smoe ------------------------------------------------------------ IRAK-Un_dm_Smoe ------------------------------------------------------------ IRAK-Un_ag_Smoe ------------------------------------------------------------ IRAK-Un_dq_Smoe ------------------------------------------------------------ IRAK-Un_dh_Smoe ------------------------------------------------------------ IRAK-Un_dp_Smoe ------------------------------------------------------------ IRAK-Un_bk-2_Smoe ------------------------------------------------------------ IRAK-Un_bk-1_Smoe ------------------------------------------------------------ IRAK-Un_ck_Smoe ------------------------------------------------------------ IRAK-Un_cn_Smoe ------------------------------------------------------------ IRAK-Un_bg_Smoe ------------------------------------------------------------ IRAK-Un_cj_Smoe ------------------------------------------------------------ IRAK-Un_v-2_Smoe ------------------------------------------------------------ IRAK-Un_de_Smoe ------------------------------------------------------------ IRAK-Un_dk_Smoe ------------------------------------------------------------ IRAK-Un_bv_Smoe ------------------------------------------------------------ IRAK-Un_ay-2_Smoe ------------------------------------------------------------ IRAK-Un_ay-1_Smoe ------------------------------------------------------------ IRAK-Un_df_Smoe ------------------------------------------------------------ IRAK-Un_bt_Smoe ------------------------------------------------------------ IRAK-Un_r_Smoe ------------------------------------------------------------ IRAK-Un_bb_Smoe ------------------------------------------------------------ IRAK-Un_v-1_Smoe ------------------------------------------------------------ IRAK-Un_bx-1_Smoe GGGGGEFSIREYIVDWVSCENRRGRSRTREWPWNAASSGTAGAAAAGTSSEGKNNVKKKK LRR10a_d-2_Smoe ------------------------------------------------------------ IRAK-Un_cz_Smoe ------------------------------------------------------------ IRAK-Un_e_Smoe ------------------------------------------------------------ IRAK-Un_dn_Smoe ------------------------------------------------------------ IRAK-Un_do_Smoe ------------------------------------------------------------ IRAK-Un_br-1_Smoe ------------------------------------------------------------ IRAK-Un_av-2_Smoe ------------------------------------------------------------ IRAK-Un_av-1_Smoe ------------------------------------------------------------ IRAK-Un_bx-2_Smoe GGGGGEFSIREYIVDWVSCENRRGRSRTREWPWNAASSGTAGAAAAGTSSEGKNNVKKKK IRAK-Un_am-1_Smoe ------------------------------------------------------------ IRAK-Un_bj-2_Smoe ------------------------------------------------------------ IRAK-Un_bj-1_Smoe ------------------------------------------------------------ RKF3_a-2_Smoe ------------------------------------------------------------ IRAK-Un_bo-2_Smoe ------------------------------------------------------------ IRAK-Un_dc_Smoe ------------------------------------------------------------ IRAK-Un_k-2_Smoe ------------------------------------------------------------ IRAK-Un_bo-1_Smoe ------------------------------------------------------------ IRAK-Un_cb_Smoe ------------------------------------------------------------ IRAK-Un_cs_Smoe ------------------------------------------------------------ IRAK-Un_cu_Smoe ------------------------------------------------------------ IRAK-Un_t_Smoe ------------------------------------------------------------ IRAK-Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bp-1_Smoe ------------------------------------------------------------ IRAK-Un_bp-2_Smoe ------------------------------------------------------------ IRAK-Un_k-1_Smoe ------------------------------------------------------------ IRAK-Un_bd_Smoe ------------------------------------------------------------ IRAK-Un_h_Smoe ------------------------------------------------------------ IRAK_Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bf_Smoe ------------------------------------------------------------ IRAK-Un_ap-1_Smoe ------------------------------------------------------------ IRAK-Un_ap-2_Smoe ------------------------------------------------------------ IRAK-Un_aw_Smoe ------------------------------------------------------------ IRAK-Un_co_Smoe ------------------------------------------------------------ IRAK-Un_ax_Smoe ------------------------------------------------------------ IRAK-Un_br-2_Smoe ------------------------------------------------------------ IRAK-Un_bw_Smoe ------------------------------------------------------------ IRAK-Un_ca_Smoe ------------------------------------------------------------ IRAK-Un_am-2_Smoe ------------------------------------------------------------ IRAK-Un_da_Smoe ------------------------------------------------------------ IRAK-Un_dg_Smoe ------------------------------------------------------------ IRAK-Un_dj_Smoe ------------------------------------------------------------ IRAK-Un_dm_Smoe ------------------------------------------------------------ IRAK-Un_ag_Smoe ------------------------------------------------------------ IRAK-Un_dq_Smoe ------------------------------------------------------------ IRAK-Un_dh_Smoe ------------------------------------------------------------ IRAK-Un_dp_Smoe ------------------------------------------------------------ IRAK-Un_bk-2_Smoe ------------------------------------------------------------ IRAK-Un_bk-1_Smoe ------------------------------------------------------------ IRAK-Un_ck_Smoe ------------------------------------------------------------ IRAK-Un_cn_Smoe ------------------------------------------------------------ IRAK-Un_bg_Smoe ------------------------------------------------------------ IRAK-Un_cj_Smoe ------------------------------------------------------------ IRAK-Un_v-2_Smoe ------------------------------------------------------------ IRAK-Un_de_Smoe ------------------------------------------------------------ IRAK-Un_dk_Smoe ------------------------------------------------------------ IRAK-Un_bv_Smoe ------------------------------------------------------------ IRAK-Un_ay-2_Smoe ------------------------------------------------------------ IRAK-Un_ay-1_Smoe ------------------------------------------------------------ IRAK-Un_df_Smoe ------------------------------------------------------------ IRAK-Un_bt_Smoe ------------------------------------------------------------ IRAK-Un_r_Smoe ------------------------------------------------------------ IRAK-Un_bb_Smoe ------------------------------------------------------------ IRAK-Un_v-1_Smoe ------------------------------------------------------------ IRAK-Un_bx-1_Smoe KQARSGSLEWWAECDDDDELAKRIKAEQKRKKNREWWSGEMQRGKEWWSGELTSNETNNN LRR10a_d-2_Smoe ------------------------------------------------------------ IRAK-Un_cz_Smoe ------------------------------------------------------------ IRAK-Un_e_Smoe ------------------------------------------------------------ IRAK-Un_dn_Smoe ------------------------------------------------------------ IRAK-Un_do_Smoe ------------------------------------------------------------ IRAK-Un_br-1_Smoe ------------------------------------------------------------ IRAK-Un_av-2_Smoe ------------------------------------------------------------ IRAK-Un_av-1_Smoe ------------------------------------------------------------ IRAK-Un_bx-2_Smoe KQARSGSLEWWAECDDDDELAKRIKAEQKRKKNREWWSGEMQRGKEWWSGELTSNETN-N IRAK-Un_am-1_Smoe ------------------------------------------------------------ IRAK-Un_bj-2_Smoe ------------------------------------------------------------ IRAK-Un_bj-1_Smoe ------------------------------------------------------------ RKF3_a-2_Smoe ------------------------------------------------------------ IRAK-Un_bo-2_Smoe ------------------------------------------------------------ IRAK-Un_dc_Smoe ------------------------------------------------------------ IRAK-Un_k-2_Smoe ------------------------------------------------------------ IRAK-Un_bo-1_Smoe ------------------------------------------------------------ IRAK-Un_cb_Smoe ------------------------------------------------------------ IRAK-Un_cs_Smoe ------------------------------------------------------------ IRAK-Un_cu_Smoe ------------------------------------------------------------ IRAK-Un_t_Smoe ------------------------------------------------------------ IRAK-Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bp-1_Smoe ------------------------------------------------------------ IRAK-Un_bp-2_Smoe ------------------------------------------------------------ IRAK-Un_k-1_Smoe ------------------------------------------------------------ IRAK-Un_bd_Smoe ------------------------------------------------------------ IRAK-Un_h_Smoe ------------------------------------------------------------ IRAK_Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bf_Smoe ------------------------------------------------------------ IRAK-Un_ap-1_Smoe ------------------------------------------------------------ IRAK-Un_ap-2_Smoe ------------------------------------------------------------ IRAK-Un_aw_Smoe ------------------------------------------------------------ IRAK-Un_co_Smoe ------------------------------------------------------------ IRAK-Un_ax_Smoe ------------------------------------------------------------ IRAK-Un_br-2_Smoe ------------------------------------------------------------ IRAK-Un_bw_Smoe ------------------------------------------------------------ IRAK-Un_ca_Smoe ------------------------------------------------------------ IRAK-Un_am-2_Smoe ------------------------------------------------------------ IRAK-Un_da_Smoe ------------------------------------------------------------ IRAK-Un_dg_Smoe ------------------------------------------------------------ IRAK-Un_dj_Smoe ------------------------------------------------------------ IRAK-Un_dm_Smoe ------------------------------------------------------------ IRAK-Un_ag_Smoe -------------------------------------------EVSPR------------ IRAK-Un_dq_Smoe -------------------------------------------EVSPRVSDAEEEEDVLS IRAK-Un_dh_Smoe ------------------------------------------------------------ IRAK-Un_dp_Smoe ------------------------------------------------------------ IRAK-Un_bk-2_Smoe ------------------------------------------------------------ IRAK-Un_bk-1_Smoe ------------------------------------------------------------ IRAK-Un_ck_Smoe ------------------------------------------------------------ IRAK-Un_cn_Smoe ------------------------------------------------------------ IRAK-Un_bg_Smoe ------------------------------------------------------------ IRAK-Un_cj_Smoe ------------------------------------------------------------ IRAK-Un_v-2_Smoe ------------------------------------------------------------ IRAK-Un_de_Smoe ------------------------------------------------------------ IRAK-Un_dk_Smoe ------------------------------------------------------------ IRAK-Un_bv_Smoe ------------------------------------------------------------ IRAK-Un_ay-2_Smoe ------------------------------------------------------------ IRAK-Un_ay-1_Smoe ------------------------------------------------------------ IRAK-Un_df_Smoe ------------------------------------------------------------ IRAK-Un_bt_Smoe ------------------------------------------------------------ IRAK-Un_r_Smoe ------------------------------------------------------------ IRAK-Un_bb_Smoe ------------------------------------------------------------ IRAK-Un_v-1_Smoe ------------------------------------------------------------ IRAK-Un_bx-1_Smoe NRKGGRLFETWSRESLSGELTRRRRRERSRSHSRDWWSGDLVSR---------------- LRR10a_d-2_Smoe ------------------------------------------------------------ IRAK-Un_cz_Smoe ------------------------------------------------------------ IRAK-Un_e_Smoe ------------------------------------------------------------ IRAK-Un_dn_Smoe ------------------------------------------------------------ IRAK-Un_do_Smoe ------------------------------------------------------------ IRAK-Un_br-1_Smoe ------------------------------------------------------------ IRAK-Un_av-2_Smoe ------------------------------------------------------------ IRAK-Un_av-1_Smoe ------------------------------------------------------------ IRAK-Un_bx-2_Smoe NRKGGRLFETWSRESLSGELTRRRRRERSRSHSRDWWSGDLVSR---------------- IRAK-Un_am-1_Smoe ------------------------------------------------------------ IRAK-Un_bj-2_Smoe ------------------------------------------------------------ IRAK-Un_bj-1_Smoe ------------------------------------------------------------ RKF3_a-2_Smoe ------------------------------------------------------------ IRAK-Un_bo-2_Smoe ------------------------------------------------------------ IRAK-Un_dc_Smoe ------------------------------------------------------------ IRAK-Un_k-2_Smoe ------------------------------------------------------------ IRAK-Un_bo-1_Smoe ------------------------------------------------------------ IRAK-Un_cb_Smoe ------------------------------------------------------------ IRAK-Un_cs_Smoe ------------------------------------------------------------ IRAK-Un_cu_Smoe ------------------------------------------------------------ IRAK-Un_t_Smoe ------------------------------------------------------------ IRAK-Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bp-1_Smoe ------------------------------------------------------------ IRAK-Un_bp-2_Smoe ------------------------------------------------------------ IRAK-Un_k-1_Smoe ------------------------------------------------------------ IRAK-Un_bd_Smoe ------------------------------------------------------------ IRAK-Un_h_Smoe ------------------------------------------------------------ IRAK_Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bf_Smoe ------------------------------------------------------------ IRAK-Un_ap-1_Smoe ------------------------------------------------------------ IRAK-Un_ap-2_Smoe ------------------------------------------------------------ IRAK-Un_aw_Smoe -----------------------------------------------------------T IRAK-Un_co_Smoe ------------------------------------------------------------ IRAK-Un_ax_Smoe -----------------------------------------------------------T IRAK-Un_br-2_Smoe ------------------------------------------------------------ IRAK-Un_bw_Smoe -----------------------------------------------------------T IRAK-Un_ca_Smoe ------------------------------------------------------------ IRAK-Un_am-2_Smoe ----------------------------------------------------------T- IRAK-Un_da_Smoe -----------------------------------------------------------T IRAK-Un_dg_Smoe -----------------------------------------------------------A IRAK-Un_dj_Smoe ------------------------------------------------------------ IRAK-Un_dm_Smoe ----------------------------------------------------------V- IRAK-Un_ag_Smoe ----VSDAEEEEDGARSRNDRYSDGEWEKTSNKDSDWYKSSKMWWCSSQVGNDDFRGEMT IRAK-Un_dq_Smoe FSLSQ----------------------------------SSKMWWCSSQVGNDDFRGEMT IRAK-Un_dh_Smoe ---------------------------------------------------------QMT IRAK-Un_dp_Smoe ----------------------------------------------------------I- IRAK-Un_bk-2_Smoe ------------------------------------------------------------ IRAK-Un_bk-1_Smoe ------------------------------------------------------------ IRAK-Un_ck_Smoe -------------------------------------------------------LTQPT IRAK-Un_cn_Smoe ------------------------------------------------------------ IRAK-Un_bg_Smoe ------------------------------------------------------------ IRAK-Un_cj_Smoe -------------------------------------------------------LTQPT IRAK-Un_v-2_Smoe ----------------------------------------------------------T- IRAK-Un_de_Smoe ----------------------------------------------------------S- IRAK-Un_dk_Smoe -----------------------------------------------------------T IRAK-Un_bv_Smoe -----------------------------------------------------------T IRAK-Un_ay-2_Smoe -----------------------------------------------------------T IRAK-Un_ay-1_Smoe -----------------------------------------------------------T IRAK-Un_df_Smoe ----------------------------------------------------------ST IRAK-Un_bt_Smoe ------------------------------------------------------------ IRAK-Un_r_Smoe ----------------------------------------------------------A- IRAK-Un_bb_Smoe ------------------------------------------------------------ IRAK-Un_v-1_Smoe ----------------------------------------------------------T- IRAK-Un_bx-1_Smoe -------------------------------------------------------VSSTP LRR10a_d-2_Smoe -----------------------------------------------------------G IRAK-Un_cz_Smoe -----------------------------------------------------------T IRAK-Un_e_Smoe ----------------------------------------------------------TL IRAK-Un_dn_Smoe -----------------------------------------------------------S IRAK-Un_do_Smoe ------------------------------------------------------------ IRAK-Un_br-1_Smoe ------------------------------------------------------------ IRAK-Un_av-2_Smoe -----------------------------------------------------------K IRAK-Un_av-1_Smoe -----------------------------------------------------------K IRAK-Un_bx-2_Smoe -------------------------------------------------------VSSTP IRAK-Un_am-1_Smoe ----------------------------------------------------------T- IRAK-Un_bj-2_Smoe -----------------------------------------------------------I IRAK-Un_bj-1_Smoe -----------------------------------------------------------I RKF3_a-2_Smoe -----------------------------------------------------------T IRAK-Un_bo-2_Smoe -----------------------------------------------------------S IRAK-Un_dc_Smoe ------------------------------------------------------------ IRAK-Un_k-2_Smoe -------------------------------------------------------LTQPT IRAK-Un_bo-1_Smoe -----------------------------------------------------------S IRAK-Un_cb_Smoe ---------------------------------------------------------IGS IRAK-Un_cs_Smoe ------------------------------------------------------------ IRAK-Un_cu_Smoe ------------------------------------------------------------ IRAK-Un_t_Smoe ------------------------------------------------------------ IRAK-Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bp-1_Smoe -----------------------------------------------------------T IRAK-Un_bp-2_Smoe -----------------------------------------------------------T IRAK-Un_k-1_Smoe -------------------------------------------------------LTQPT IRAK-Un_bd_Smoe ---------------------------------------------------------QMT IRAK-Un_h_Smoe -----------------------------------------------------------T IRAK_Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bf_Smoe -----------------------------------------------------------T IRAK-Un_ap-1_Smoe -----------------------------------------------------------T IRAK-Un_ap-2_Smoe -----------------------------------------------------------T IRAK-Un_aw_Smoe V----VAGTH-GYLAPEF-V-------------YRNE---LTTKSDVYSFGVLMLELISG IRAK-Un_co_Smoe ------------------------------------------------------------ IRAK-Un_ax_Smoe R----AAGTV-GYLALEY-A-------------LSGQ---FTEKADVYSFGILVLEILSG IRAK-Un_br-2_Smoe ---------A-AYAAPEL-L-------------QRGTQSLPSPKSNVWSFGVVLLEILTG IRAK-Un_bw_Smoe V----MRGTP-GYMAP-------------------------------------------- IRAK-Un_ca_Smoe ------------------------------------------------------------ IRAK-Un_am-2_Smoe C----AQGTL-GYLDPEY-Y-------------RKYQ---LTDKSDVYSFGVVLLELV-- IRAK-Un_da_Smoe R----VMGTF-GYVAPEY-A-------------NTGL---LNERSDVYSFGVLLMEVVTG IRAK-Un_dg_Smoe L----VRKTG-GYVDPEI-V-------------HRGV---YSRAGDVFSFGVLLLEVLSG IRAK-Un_dj_Smoe ------------------------------------------------------------ IRAK-Un_dm_Smoe E----VRGTT-GYLDPEY-Y-------------MTQV---LTTKSDVFSFGVVLLEIVCG IRAK-Un_ag_Smoe D----CVGTR-WYKAPEL-L-------------YGST--SYNFAVDLWAVGCILGELIQG IRAK-Un_dq_Smoe D----CVGTR-WYKAPEL-L-------------YGST--SYNFAVDLWAVGCILGELIQG IRAK-Un_dh_Smoe S----MRGTP-GYLAPEY-L-------------QVGT---ITEKSDVFSFGVLLLEIITG IRAK-Un_dp_Smoe G----AQGTA-GYLDPEY-H-------------QCYA---LTDKSDVYSFGVLLMELITA IRAK-Un_bk-2_Smoe ------------------------------------------------------------ IRAK-Un_bk-1_Smoe ------------------------------------------------------------ IRAK-Un_ck_Smoe R----LVGTF-GYMSPEY-A-------------RYGD---VSPFLDVYSFGVVLFEI--- IRAK-Un_cn_Smoe ------------------------------------------------------------ IRAK-Un_bg_Smoe ------------------------------------------------------------ IRAK-Un_cj_Smoe R----LVGTF-GYMSPEY-A-------------RYGD---VSPFLDVYSFGVVLFEI--- IRAK-Un_v-2_Smoe A----PQGTP-GYVDPDY-H-------------QSFQ---LSDKSDVYSFGVVLVEMI-- IRAK-Un_de_Smoe G----IKGTF-GYTDPEY-I-------------FTKV---FNEKSDVYSFGVLLFELMSG IRAK-Un_dk_Smoe G----IAGTL-GYIAPEV-V-------------STCR---LSEKTDVYSFGIVLLELLTG IRAK-Un_bv_Smoe T----LAGTL-GYIAPEV-G-------------VTYK---FTPASDVYSYGVVTLEVVTG IRAK-Un_ay-2_Smoe R----AAGTA-GYLAPEY-A-------------LYGQ---LTVKADVYSFGILVLEIISG IRAK-Un_ay-1_Smoe R----AAGTA-GYLAPEY-A-------------LSGQ---LTEKADVYSFGILVLEIISG IRAK-Un_df_Smoe S----PVGTF-AYIDPEY-Q-------------REGS---FNAKSDVFAFGIILLQLL-- IRAK-Un_bt_Smoe -----GLGTQ-GYVAP-------------------------------------------- IRAK-Un_r_Smoe T----MVGTP-GYMDPEY-F-------------QTAK---FTTKSDVYSFGVVLLELLTG IRAK-Un_bb_Smoe ------------------------------------------------------------ IRAK-Un_v-1_Smoe A----PQGTP-GYVDPDY-H-------------QSFQ---LSDKSDVYSFGVVLVEMI-- IRAK-Un_bx-1_Smoe S----MRGTV-CYVAPEY-G-------------GGGV---LTEKSDVYSFGVLLLVVVSG LRR10a_d-2_Smoe AGGKSNSDEDGFYVPPEDYSTTYSLSRATSMSAASTT---ATPKGDVYAFGVVLLELVTG IRAK-Un_cz_Smoe V----VAGTH-GYLAPEF-V-------------YRNE---LTTKSDVYSFGVLMLELISG IRAK-Un_e_Smoe R----IQGTP-GYCDPEL-M-------------TTFR---LTDKSDVYSFGVVLLELVTG IRAK-Un_dn_Smoe K----VAGTF-GYMAPEY-A-------------VHRR---LSPKADVFSFGVPVLVILSG IRAK-Un_do_Smoe ------------------------------------------------------------ IRAK-Un_br-1_Smoe ---------A-AYAAPEL-L-------------QRGAQSLPSPKSNVWSFGVVLLEILTG IRAK-Un_av-2_Smoe S----YSTNL-AYTPPEY-L-------------RTGR---VTPESVIYSYGTVLLDLLSG IRAK-Un_av-1_Smoe S----YSTNL-AYTPPEY-L-------------RTGR---VTPESVIYSYGTVLLDLLSG IRAK-Un_bx-2_Smoe S----MRGTV-CYVAPEY-G-------------GGGV---LTEKSDVYSFGVLLLVVVSG IRAK-Un_am-1_Smoe C----AQGTL-GYLDPEY-Y-------------RKYQ---LTDKSDVYSFGVVLLELV-- IRAK-Un_bj-2_Smoe K----TSAML-GYLAPEY-G-------------VIGH---LHEKSDVYAFGILLLELLTG IRAK-Un_bj-1_Smoe K----TSAML-GYLAPEY-G-------------VIGH---LHEKSDVYAFGILLLELLTG RKF3_a-2_Smoe R----VAGTP-IYMAVEY-A-------------LYGQ---CSDKVDVYSFGVLLLELMSG IRAK-Un_bo-2_Smoe A-----NGSSSHFADPAAVY-------------NTYR---VDPKSDVYSYGVFLLELISG IRAK-Un_dc_Smoe ------------------------------------------------------------ IRAK-Un_k-2_Smoe R----LVGTF-GYMPPEY-A-------------RFGD---VSPKIDVYSFGVVLYEI--- IRAK-Un_bo-1_Smoe A-----NGSSSHFADPAAVY-------------NTYR---VDPKSDVYSYGVFLLELISG IRAK-Un_cb_Smoe T----VVGTY-GYMAPEQ-F-------------Q-NR---ATLQTDLYGLGGTLLFMLSG IRAK-Un_cs_Smoe ------------------------------------------------------------ IRAK-Un_cu_Smoe ------------------------------------------------------------ IRAK-Un_t_Smoe ------------------------------------------------------------ IRAK-Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bp-1_Smoe R----VAGTI-GYLSPEY-A-------------MRGQ---LTEKADVYSFGVLVLEIVSG IRAK-Un_bp-2_Smoe R----VAGTI-GYLSPEY-A-------------MRGQ---LTEKADVYSFGVLVLEVVSG IRAK-Un_k-1_Smoe R----LVGTF-GYMPPEY-A-------------RFGD---VSPKIDVYSFGVVLYEI--- IRAK-Un_bd_Smoe S----MRGTP-GYLAPEY-L-------------QVGT---ITEKSDVFSFGVLLLEIITG IRAK-Un_h_Smoe Q----VAGTI-GYIAPEY-H-------------QTCK---FTVSSDVYSMGIVLGVLISG IRAK_Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bf_Smoe R----VAGTF-GYLAPEY-A-------------LRGK---LTEKADVYSFGILLLEILSG IRAK-Un_ap-1_Smoe R----AAGTV-GYLAPEY-A-------------LSGQ---LTEKADVYSFGILVLEILSG IRAK-Un_ap-2_Smoe R----ATGTV-GYLAPEY-A-------------LSGQ---LTEKADVYSFEILVLEILSG IRAK-Un_aw_Smoe R---------------------------------------K------------------- IRAK-Un_co_Smoe ------------------------------------------------------------ IRAK-Un_ax_Smoe ------------------------------------------------------------ IRAK-Un_br-2_Smoe RQNRDEMFAVEEQDLVGWTAPYLANDKKLFLVVDPELKGMF------------------- IRAK-Un_bw_Smoe ------------------------------------------------------------ IRAK-Un_ca_Smoe ------------------------------------------------------------ IRAK-Un_am-2_Smoe ------------------------------------------------------------ IRAK-Un_da_Smoe R---------------------------------------D------------------- IRAK-Un_dg_Smoe KQA--------------------------------------------------------- IRAK-Un_dj_Smoe ------------------------------------------------------------ IRAK-Un_dm_Smoe R---------------------------------------E------------------- IRAK-Un_ag_Smoe EP---------------------------------------LFPGAS-DIDQLS------ IRAK-Un_dq_Smoe EP---------------------------------------LFPGAS-DIDQLS------ IRAK-Un_dh_Smoe C---------------------------------------RNKYMSS-DYLRSFSL---- IRAK-Un_dp_Smoe K----------------------------------------------------------- IRAK-Un_bk-2_Smoe ------------------------------------------------------------ IRAK-Un_bk-1_Smoe ------------------------------------------------------------ IRAK-Un_ck_Smoe ------------------------------------------------------------ IRAK-Un_cn_Smoe ------------------------------------------------------------ IRAK-Un_bg_Smoe ------------------------------------------------------------ IRAK-Un_cj_Smoe ------------------------------------------------------------ IRAK-Un_v-2_Smoe ------------------------------------------------------------ IRAK-Un_de_Smoe R---------------------------------------HPQHGLM-DYVQMASL---- IRAK-Un_dk_Smoe R---------------------------------------K------------------- IRAK-Un_bv_Smoe ------------------------------------------------------------ IRAK-Un_ay-2_Smoe ------------------------------------------------------------ IRAK-Un_ay-1_Smoe ------------------------------------------------------------ IRAK-Un_df_Smoe ------------------------------------------------------------ IRAK-Un_bt_Smoe ------------------------------------------------------------ IRAK-Un_r_Smoe ------------------------------------------------------------ IRAK-Un_bb_Smoe ------------------------------------------------------------ IRAK-Un_v-1_Smoe ------------------------------------------------------------ IRAK-Un_bx-1_Smoe R---------------------------------------RP------------------ LRR10a_d-2_Smoe R---------------------------------------R------------------- IRAK-Un_cz_Smoe R---------------------------------------K------------------- IRAK-Un_e_Smoe Q---------------------------------------K------------------- IRAK-Un_dn_Smoe ------------------------------------------------------------ IRAK-Un_do_Smoe ------------------------------------------------------------ IRAK-Un_br-1_Smoe RQNRDEMFAVEEQDLVGWTAPYLANDKKLFLVVDPELKGMF------------------- IRAK-Un_av-2_Smoe KHIPPSHA------------LDLIRGKNILMLMDSYLEGQF------------------- IRAK-Un_av-1_Smoe KHIPPSHA------------LDLIRGKNILMLMDSYLEGQF------------------- IRAK-Un_bx-2_Smoe R---------------------------------------RP------------------ IRAK-Un_am-1_Smoe ------------------------------------------------------------ IRAK-Un_bj-2_Smoe R---------------------------------------KPM----------------- IRAK-Un_bj-1_Smoe R---------------------------------------KPM----------------- RKF3_a-2_Smoe ------------------------------------------------------------ IRAK-Un_bo-2_Smoe ------------------------------------------------------------ IRAK-Un_dc_Smoe ------------------------------------------------------------ IRAK-Un_k-2_Smoe ------------------------------------------------------------ IRAK-Un_bo-1_Smoe ------------------------------------------------------------ IRAK-Un_cb_Smoe RS---------------------------------------PATFPQ-KRLR-------- IRAK-Un_cs_Smoe ------------------------------------------------------------ IRAK-Un_cu_Smoe ------------------------------------------------------------ IRAK-Un_t_Smoe ------------------------------------------------------------ IRAK-Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bp-1_Smoe ------------------------------------------------------------ IRAK-Un_bp-2_Smoe ------------------------------------------------------------ IRAK-Un_k-1_Smoe ------------------------------------------------------------ IRAK-Un_bd_Smoe ------------------------------------------------------------ IRAK-Un_h_Smoe R---------------------------------------EPTDEFFKDF----PGGIVP IRAK_Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bf_Smoe ------------------------------------------------------------ IRAK-Un_ap-1_Smoe ------------------------------------------------------------ IRAK-Un_ap-2_Smoe ------------------------------------------------------------ IRAK-Un_aw_Smoe ------------------------------------------------------------ IRAK-Un_co_Smoe ------------------------------------------------------------ IRAK-Un_ax_Smoe ------------------------------------------------------------ IRAK-Un_br-2_Smoe ------------------------------------------------------------ IRAK-Un_bw_Smoe ------------------------------------------------------------ IRAK-Un_ca_Smoe ------------------------------------------------------------ IRAK-Un_am-2_Smoe ------------------------------------------------------------ IRAK-Un_da_Smoe ------------------------------------------------------------ IRAK-Un_dg_Smoe ------------------------------------------------------------ IRAK-Un_dj_Smoe ------------------------------------------------------------ IRAK-Un_dm_Smoe ------------------------------------------------------------ IRAK-Un_ag_Smoe ------RVVRVLGVPNETIWPG-------------ISSLPDYDKICFNDDRPPVTLARIL IRAK-Un_dq_Smoe ------RVVRVLGVPNETIWPG-------------ISSLPDYDKICFNDDRPPVTLARIL IRAK-Un_dh_Smoe --GDFSRQKSFTKSIS-----KTRKNLCDGGSSGGVA--------------------DKY IRAK-Un_dp_Smoe ------------------------------------------------------------ IRAK-Un_bk-2_Smoe ------------------------------------------------------------ IRAK-Un_bk-1_Smoe ------------------------------------------------------------ IRAK-Un_ck_Smoe ------------------------------------------------------------ IRAK-Un_cn_Smoe ------------------------------------------------------------ IRAK-Un_bg_Smoe ------------------------------------------------------------ IRAK-Un_cj_Smoe ------------------------------------------------------------ IRAK-Un_v-2_Smoe ------------------------------------------------------------ IRAK-Un_de_Smoe --GVDEENSDWIELLD-----SRL------------N--------------------GNC IRAK-Un_dk_Smoe ------------------------------------------------------------ IRAK-Un_bv_Smoe ------------------------------------------------------------ IRAK-Un_ay-2_Smoe ------------------------------------------------------------ IRAK-Un_ay-1_Smoe ------------------------------------------------------------ IRAK-Un_df_Smoe ------------------------------------------------------------ IRAK-Un_bt_Smoe ------------------------------------------------------------ IRAK-Un_r_Smoe ------------------------------------------------------------ IRAK-Un_bb_Smoe ------------------------------------------------------------ IRAK-Un_v-1_Smoe ------------------------------------------------------------ IRAK-Un_bx-1_Smoe ------------------------------------------------------------ LRR10a_d-2_Smoe ------------------------------------------------------------ IRAK-Un_cz_Smoe ------------------------------------------------------------ IRAK-Un_e_Smoe ------------------------------------------------------------ IRAK-Un_dn_Smoe ------------------------------------------------------------ IRAK-Un_do_Smoe ------------------------------------------------------------ IRAK-Un_br-1_Smoe ------------------------------------------------------------ IRAK-Un_av-2_Smoe ------------------------------------------------------------ IRAK-Un_av-1_Smoe ------------------------------------------------------------ IRAK-Un_bx-2_Smoe ------------------------------------------------------------ IRAK-Un_am-1_Smoe ------------------------------------------------------------ IRAK-Un_bj-2_Smoe ------------------------------------------------------------ IRAK-Un_bj-1_Smoe ------------------------------------------------------------ RKF3_a-2_Smoe ------------------------------------------------------------ IRAK-Un_bo-2_Smoe ------------------------------------------------------------ IRAK-Un_dc_Smoe ------------------------------------------------------------ IRAK-Un_k-2_Smoe ------------------------------------------------------------ IRAK-Un_bo-1_Smoe ------------------------------------------------------------ IRAK-Un_cb_Smoe -----------------------------------------------------VDFQN-F IRAK-Un_cs_Smoe ------------------------------------------------------------ IRAK-Un_cu_Smoe ------------------------------------------------------------ IRAK-Un_t_Smoe ------------------------------------------------------------ IRAK-Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bp-1_Smoe ------------------------------------------------------------ IRAK-Un_bp-2_Smoe ------------------------------------------------------------ IRAK-Un_k-1_Smoe ------------------------------------------------------------ IRAK-Un_bd_Smoe ------------------------------------------------------------ IRAK-Un_h_Smoe WMCYLVQSGQELRGID-----PTL------------LKPAARGGGEGGGDDTLGQTPGFA IRAK_Un_dd_Smoe ------------------------------------------------------------ IRAK-Un_bf_Smoe ------------------------------------------------------------ IRAK-Un_ap-1_Smoe ------------------------------------------------------------ IRAK-Un_ap-2_Smoe ------------------------------------------------------------ IRAK-Un_aw_Smoe --------------------------------------P IRAK-Un_co_Smoe --------------------------------------R IRAK-Un_ax_Smoe --------------------------------------R IRAK-Un_br-2_Smoe PAR---SVSLFAKLAAQCLQRDPAARP-SMDQ--VVQSL IRAK-Un_bw_Smoe --------------------------------------E IRAK-Un_ca_Smoe --------------------------------------R IRAK-Un_am-2_Smoe --------------------------------------T IRAK-Un_da_Smoe --------------------------------------P IRAK-Un_dg_Smoe ----------------------------------FSEET IRAK-Un_dj_Smoe --------------------------------------G IRAK-Un_dm_Smoe --------------------------------------P IRAK-Un_ag_Smoe -PR---ASGEALRLIEKLLVYDPASRL-SASQALSHEFF IRAK-Un_dq_Smoe -PR---ASGEALRLIEKLLVYDPASRL-SASQALSHEFF IRAK-Un_dh_Smoe Q---AAGMERLKAVAYLCVQDDPDMRP-SMST---ALKM IRAK-Un_dp_Smoe --------------------------------------P IRAK-Un_bk-2_Smoe --------------------------------------G IRAK-Un_bk-1_Smoe --------------------------------------G IRAK-Un_ck_Smoe --------------------------------------I IRAK-Un_cn_Smoe --------------------------------------A IRAK-Un_bg_Smoe --------------------------------------V IRAK-Un_cj_Smoe --------------------------------------I IRAK-Un_v-2_Smoe --------------------------------------T IRAK-Un_de_Smoe NLQ---ELAKLASIAHRCVRKDPETRP-PMRE--IVQWL IRAK-Un_dk_Smoe --------------------------------------P IRAK-Un_bv_Smoe --------------------------------------R IRAK-Un_ay-2_Smoe --------------------------------------R IRAK-Un_ay-1_Smoe --------------------------------------R IRAK-Un_df_Smoe --------------------------------------T IRAK-Un_bt_Smoe --------------------------------------E IRAK-Un_r_Smoe --------------------------------------R IRAK-Un_bb_Smoe --------------------------------------F IRAK-Un_v-1_Smoe --------------------------------------T IRAK-Un_bx-1_Smoe -------------------------------------LQ LRR10a_d-2_Smoe --------------------------------------P IRAK-Un_cz_Smoe --------------------------------------P IRAK-Un_e_Smoe --------------------------------------P IRAK-Un_dn_Smoe --------------------------------------R IRAK-Un_do_Smoe --------------------------------------S IRAK-Un_br-1_Smoe PAR---SVSLFAKLAAQCLQRDPAARP-SMDQ--VVQSL IRAK-Un_av-2_Smoe SND---DGTELVRLASRCLQYEPRERP-TAKM--LVQAL IRAK-Un_av-1_Smoe SND---DGTELVRLASRCLQYEPRERP-TAKM--LVQAL IRAK-Un_bx-2_Smoe -------------------------------------LQ IRAK-Un_am-1_Smoe --------------------------------------T IRAK-Un_bj-2_Smoe ------------------------------------YAD IRAK-Un_bj-1_Smoe ------------------------------------YAD RKF3_a-2_Smoe --------------------------------------R IRAK-Un_bo-2_Smoe --------------------------------------R IRAK-Un_dc_Smoe --------------------------------------P IRAK-Un_k-2_Smoe --------------------------------------I IRAK-Un_bo-1_Smoe --------------------------------------R IRAK-Un_cb_Smoe -VS---ASPSMTRVVEKLLEPAPEDRYQSADE--VIRAL IRAK-Un_cs_Smoe --------------------------------------D IRAK-Un_cu_Smoe --------------------------------------G IRAK-Un_t_Smoe --------------------------------------G IRAK-Un_dd_Smoe --------------------------------------S IRAK-Un_bp-1_Smoe --------------------------------------R IRAK-Un_bp-2_Smoe --------------------------------------R IRAK-Un_k-1_Smoe --------------------------------------I IRAK-Un_bd_Smoe --------------------------------------C IRAK-Un_h_Smoe NLDEITEMKRAMRIACLCTKLNPQDRP-STKD---VLVM IRAK_Un_dd_Smoe --------------------------------------E IRAK-Un_bf_Smoe --------------------------------------R IRAK-Un_ap-1_Smoe --------------------------------------R IRAK-Un_ap-2_Smoe --------------------------------------R