CLUSTAL W (1.83) multiple sequence alignment IRAKg_e-1_Smoe --FKDKLGAGAFGTVYKGVL--ADGTSLVAVKSLMM-ATHAEKQFKAEVATLGKIHHINL IRAKg_d-2_Smoe --FYDRLGSGGFGTVYKGRL--PNG-TLVAVKELEM-AMQADKQFQAEVKTLGKIHHINL IRAKg_r-1_Smoe --FRDELGSGGFGSVYRGNI--PEKGGIVAVKKITT-VNQAKKQFKAEVSTIGRVHHVNL IRAKg_d-1_Smoe --FYDRLGSGGFGTVYKGRL--PNG-TLVAVKELEM-AMQADKQFQAEVKTLGKIHHINL IRAKg_f_Smoe --FKDKLGTGGFGTVFKGLL--PDG-IIVAVKNIEM-EIQAEKQFQAEVTTLGNIHHINL IRAKg_e-2_Smoe --FKDKLGAGAFGTVYKGVL--ADGTSLVAVKSLMM-ATHAEKQFKAEVATLGKIHHINL IRAKg_o_Smoe ----------------------------------------------AEVSTIGRVHHVNL IRAKg_v_Smoe --FSDKIGAGILGSVYKGVF--PDSETVVAVKKLE-IN-TSDRDFRNCVSEIGFLSHDSL IRAKg_s_Smoe ---------------------------------------------------LGRVHHVNL IRAKg_q_Smoe ---------------------------------------------------LGRVHHVNL IRAKg_a-1_Smoe YNFQTRIGEGGFGPVYKGSLALPVSKTAIAVKKLEG-IFQGEKEFRTEVATIGSTHHMNL IRAKg_a-2_Smoe YNFQTRIGEGGFGPVYKGSIALPVSKTAIAVKKLEG-IFQGEKEFRTEVATIGSTHHMNL IRAKg_g_Smoe ---------------------------------------------------LGKIHHISL IRAKg_u-2_Smoe NHFSCKLGAGGFGSVYKGVL--PDM-TVVAVKTLEGAASHGEKQFKAEVATLGRVHHVNL IRAKg_p_Smoe --FRNELGSGGFESVYRGNI--PEKGGIVAVKKITT-VNQAEKQCKAEVSTIGRVHHVNL IRAKg_b_Smoe ----DKLGSGGFGTVYKGRL--PNG-TLVAVKELEM-AMQADKQFQAEVKTLGKIHHINL IRAKg_n-2_Smoe ----DKLGSGGFGTVYKGRL--LNG-TLVAVKELEM-AMQADKQFQTEVETLGKIHHINL IRAKg_k-1_Smoe ------------------------------------------------------------ IRAKg_n-1_Smoe ----DKLGSGGFGTVYKGRL--LNG-TLVAVKELQM-AMQADKQFQTEVETLGKIHHINL IRAKg_h_Smoe ----DKLGSGGFGTVYKGRL--PNG-TLVAVKELEI-AMQADKQFQAEVKTLGKIHHINL IRAKg_k-2_Smoe ------------------------------------------------------------ IRAKg_r-2_Smoe --FRDELGSGGFGSVYRGNI--PEKGGIVAVKKITT-VNQAKKQFKAEVSTIGRVHHVNL IRAKg_m-1_Smoe --FEETLGSGGYGTVYRGEI--PEKGGIVAVKVIKA-VTHAEKQFKAEVNTIGKVHHVNL IRAKg_u-1_Smoe NHFSCKLGAGGFGSVYKGVL--PDM-TVVAVKTLEGAASHGEKQFKAEVATLGRVHHVNL IRAKg_c_Smoe --FKDKLGTGGFGTVFKGLL--PDG-IIVAVKNIEM-EIQAEKQFQAEVTTLGKIHHINL IRAKg_o-1_Smoe --FRHKLGSGGFGSVYKGVL--PDK-TVVAVKTLEV-ATHGENQFKAEVATLGTIHHVNL IRAKg_m-2_Smoe --FEETLGSGGYGTVYRGEI--PEKGGIVAVKVIKA-VTHAEKQFKAEVNTIGKVHHVNL IRAKg_o-2_Smoe --FRHKLGSGGFGSVYKGVL--PDK-TVVAVKTLEV-ATHGENQFKAEVATLGTIHHVNL IRAKg_e-1_Smoe VRMLGYCAEGS--HRLLVYEYMENSSLEKVLS-QV--------------PKTLCEWKTRL IRAKg_d-2_Smoe VRLLGYCYEDN--RKLLVYEYMPNGSLEKLLFLND--------------TEHFCGWASRF IRAKg_r-1_Smoe VRLLGYCAEGD--HHLLVYEFMPNGSLDHHLSASSSF---------AASQEIFSTWETRH IRAKg_d-1_Smoe VRLLGYCYEDN--RKLLVYEYMPNSSLEKLLFLND--------------TEHFCGWASRF IRAKg_f_Smoe VRLLG------------------------------------------------------- IRAKg_e-2_Smoe VRMLGYCAEGS--HRLLVYEYMANSSLEKVLS-QV--------------PQTLCEWKTRL IRAKg_o_Smoe VRLLGYCAEGG--CHLLVYEFMPNGSLDHHLSASSSF---------AASQEIFSTWETQH IRAKg_v_Smoe VQLHGFCADCGPDNKMLVYEFLSNGSLDKLLFEDS--------------EDNRLDWKFRF IRAKg_s_Smoe VKLLGYCAEGS--HRLLVYEFLSNGSLDQDLST---------------------KLVCRF IRAKg_q_Smoe VKLLGYCAEGS--HRLLVYEFLSNGSLDQECID---------------------LWGTRF IRAKg_a-1_Smoe MRLVGFCAEGA-ATRLLVYEFLPNGSLDRFLFQPLAPGEDED--DSYQEARPSLDWPTRF IRAKg_a-2_Smoe MRLVGFCAEGA-ETRLLVYEFLPNGSLDRFLFQPLAPGEDED--DSYQGARPSLDWPTRF IRAKg_g_Smoe VRMLGYCAEGS--HRLLVYEYMANSLQVDEASSQI--------------PQTLCKWKTRL IRAKg_u-2_Smoe VKLLGYCAEGS--HRLLVYEFLSNGSLDQECID---------------------LWGTRY IRAKg_p_Smoe VRLLGYCAEGD--RHLLVYQFMTNGSLDHHLSASSSS---------AASQEIFSTSETQH IRAKg_b_Smoe VRLLGYCYEDN--RKLLVYEYMPNGSLDKLLFL--------------------DSWASRF IRAKg_n-2_Smoe VRLLGYCYEDN--RKLLVYEYMPNGSLEKLLFLDD--------------AKHFCSWANRF IRAKg_k-1_Smoe ----------------LVYEFIERGSLDRTLFNRD------------AENSVVLSWSQRF IRAKg_n-1_Smoe VRLLGYCYEDN--RKLLVYEYMPNGSLEKLLFLDD--------------AKHFCSWASRF IRAKg_h_Smoe VRLLG--------------------------------------------------WASRF IRAKg_k-2_Smoe ----------------LVYEFVERGSLDRTLFNRD------------AENSVVLSWSQRF IRAKg_r-2_Smoe VRLLGYCAEGD--HHLLVYEFMPNGSLDHHLSASSSF---------AASQEIFSTWETRH IRAKg_m-1_Smoe VRLLGYCVEGV--HRLLVYEFMPNGSLDNYLSSNS--------------GSSDSSWQTRF IRAKg_u-1_Smoe VKLLGYCAEGS--HRLLVYEFLSNGSLDQECSD---------------------LWGTRY IRAKg_c_Smoe VRLLGYCAEGS--HRLLVYEYMQNGSLEKSIISNED------------IDESLCDWKTRF IRAKg_o-1_Smoe VKLLGYCVEGS--HRVLVYEYMTNGSLDKVLTSIRAPWKTRYCHRKSQSPKVKLTLLFRY IRAKg_m-2_Smoe VRLLGYCVEGV--HRLLVYEFMPNGSLDNYLSSNS--------------GSSDSSWQTRF IRAKg_o-2_Smoe VKLLGYCVEGS--HRVLVYEYMTNGSLDKVLTSIRAPWKTRYCHRKSQSPKVKLTLLFRY IRAKg_e-1_Smoe AIALGISRGITYLHEQCQECIIHCDIKPQNILLDDNFRPKVSDFGLAKLMKRESSANVTT IRAKg_d-2_Smoe NIALGIARGITYLHDECQECILHCDIKPQNILLDESFIPKVADFGLAKLMKRERELSVTT IRAKg_r-1_Smoe SIALGIAKGLTYLHEKCGERIVHCDIKPQNVLLNESFRPKVSDFGLARMMTKE-SMSITT IRAKg_d-1_Smoe NIALGIARGITYLHDECQECILHCDIKPQNILLDESFIPKVADFGLAKLMKRERALSVTT IRAKg_f_Smoe ------------------------------------------------------------ IRAKg_e-2_Smoe AIALGISRGITYLHEQCQECIIHCDIKPQNILLDDNFRPKVSDFGLAKLMKRESSANVTT IRAKg_o_Smoe SIALGIAKGLTYLHEKCGERIVHCDIKPQNVLLD-------------------------- IRAKg_v_Smoe DTALSIARGVAHLHQQ-QVPVIHGNLKTENILLDKNFQPKISDTGLGLLVDRRKIKTALS IRAKg_s_Smoe SIALGVAKRITYLHKECYDCILR-DIKPQNILLHENFCPKVSDFGLAKLIDKERALDVTT IRAKg_q_Smoe SIALGVAKGITYLHE-CYDCILR-DIKPQNILLDENFCPKVLDFGLAKLIDKERALDVTT IRAKg_a-1_Smoe KIALGTARALAYLHEECREPIVHCDLKPENILLDDSFAPKVSDFGLARLIDEGNARNLTT IRAKg_a-2_Smoe KIALGTARALAYLHEECREPIVHCDLKPENILLDDSFAPKVSDFGLARLIDEGNARNLTT IRAKg_g_Smoe AIALSISRGITYLHQQCQECIIHCDVKPQNILFDDNFHPKVSDFGLAKLMKRESSANVTT IRAKg_u-2_Smoe SIALGVAKGITYLHEECYDCVLHCDIKPQNVLLDENFCPKVSDFGLAKLIDKERALDVTT IRAKg_p_Smoe SIALGIAKGLTYLLWRAHRPLRYQATK------RAAGRPKVADFGLARMMRKE-SMSVTT IRAKg_b_Smoe NIALGIARGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRERALSVTT IRAKg_n-2_Smoe SIALGIARGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRERALSVTT IRAKg_k-1_Smoe GIALGTAKGLAYLHEDCRHRIIHCDIKPENILLDAEMKPKIADFGLAKLLGREFSRVVTS IRAKg_n-1_Smoe SIALGIARGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRERALSVTT IRAKg_h_Smoe NIALGIARGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLM---------- IRAKg_k-2_Smoe GIALGTAKGLAYLHEDCRHRIIHCDIKPENILLDAEMKPKIADFGLAKLLGREFSRVVTS IRAKg_r-2_Smoe SIALGIAKGLTYLHEKCGERIVHCDIKPQNVLLNESFRPKVSDFGLARMMTKE-SMSITT IRAKg_m-1_Smoe SIALGIAKGIAYLHEECQECIIHCDIKPQNILLDDQMSPKIADFGLAKLTKREHSMSVTT IRAKg_u-1_Smoe SIALGVAKGITYLHEECYDCILHCDIKPQNVLLDENFCPKVSDFGLAKLTDKERALDVTT IRAKg_c_Smoe SIAVGIARGITYLHEQCQECIVHCDIKPQNILLDEKFCPKVSDFGLAKLASRERTINVTT IRAKg_o-1_Smoe SIAMGIARGITYLHEECYECILHCDIKPQNILLDQNLCPKVADFGLAKLTKREMALNVTT IRAKg_m-2_Smoe SIALGIAKGIAYLHEECQECIIHCDIKPQNILLDDQMSPKIADFGLAKLTKREHSMSVTT IRAKg_o-2_Smoe SIAMGIARGITYLHEECYECILHCDIKPQNILLDQNLCPKVADFGLAKLTKKEMALNVTT IRAKg_e-1_Smoe ARGTRGYMAPEWISNVAITPKVDVYSFGMVLLELMSGR---------------------- IRAKg_d-2_Smoe VRGTRGYLAPEWISNLPITTKVDVYSFGMVLLEIISGREKYLMTISAINSENNRWCLSDW IRAKg_r-1_Smoe VQGTRGYLAPEWLESQSITPKADVYSFGMLLLDILGGK---------------------- IRAKg_d-1_Smoe VRGTRGYLAPEWISDLPITTKADVYSFGMVLLEIISGREKYLMTISAINSENNRWCLSDW IRAKg_f_Smoe ------------------------------------------------------------ IRAKg_e-2_Smoe ARGTRGYMAPEWISNVAITPKVDVYSFGMVLLELMSGR---------------------- IRAKg_o_Smoe -------------------------------------E---------------------- IRAKg_v_Smoe SGRVHGYFSPEWIADSPLTTKTDVYGFGMILLEIIGGR---------------------- IRAKg_s_Smoe IRGTRGYMAPEWVGDRPITSKVDVYIYGMVLLELLS-G---------------------- IRAKg_q_Smoe IRGTRGYMAPVWVGDRPITSKVDVYSYGMVLLELLS-G---------------------- IRAKg_a-1_Smoe VRGTRGYMAPEWLANMPITAKSDVYSYGMVLLELVGG----------------------- IRAKg_a-2_Smoe VRGTRGYMAPEWLANMPITAKSDVYSYGMVVLELVGG----------------------- IRAKg_g_Smoe ARDTRGYMAPEWISMVAIAPKVDVYSFGMVL----------------------------- IRAKg_u-2_Smoe IRGTRGYMAPEWVGDRPITSKVDVYSYGMVLLELLS-G---------------------- IRAKg_p_Smoe VQGTRGYLAPEWLESQSITPKANVYSFGMLLLDILSGK---------------------- IRAKg_b_Smoe VRGTRGYLAPEWISNLPITTKVDVYSFGMVLLEIISGREKYLMTISAINSENNRWCLSDW IRAKg_n-2_Smoe VRGTRGYLAPEWISNLPITTKVDVYSFGMVLLEIISGR---------------------- IRAKg_k-1_Smoe MRGTRGYLAPEWLSNMPITPKADVYSYGMTLLEIISG----------------------- IRAKg_n-1_Smoe VRGTRGYLAPEWISNLPITTKVDVYSFGMVLLEIISGREKYIMTISAINSENSRWCLSDW IRAKg_h_Smoe ------------------------------------------------------------ IRAKg_k-2_Smoe MRGTRGYLAPEWLSNMPITPKADVYSYGMTLLEIISG----------------------- IRAKg_r-2_Smoe VQGTRGYLAPEWLESQSITPKADVYSFGMLLLDILGGK---------------------- IRAKg_m-1_Smoe VRGTRGYLAPEWLDGLSVTPKIDVYSFGMLLFDILSGT---------------------- IRAKg_u-1_Smoe IRGTRGYMAPEWVGDRPITSKVDVYSYGMVLLELLS-G---------------------- IRAKg_c_Smoe VQGTRGYMAPEWVRNVTITPKVDVYSYGMVLFELLS------------------------ IRAKg_o-1_Smoe IRGTRGYLAPEWISNRPITTKVDVYSYGMVLLELLSGH---------------------- IRAKg_m-2_Smoe VRGTRGYLAPEWLDGLSVTPKIDVYSFGMLLFDILSGT---------------------- IRAKg_o-2_Smoe IRGTRGYLAPEWISNRPITTKVDVYSYGMVLLELLSGH---------------------- IRAKg_e-1_Smoe ------------------------------------------------------- IRAKg_d-2_Smoe AYNMYQAGDLESIIDKKLVREDVDLVQFKRLLKVALWCIQHDANARPSMGKVVQM IRAKg_r-1_Smoe ------------------------------------------------------- IRAKg_d-1_Smoe AYNMYQAGDLESIVDKKLVREEVDLVQFKRLLKVALWCIQHDANARPSMGKVVQM IRAKg_f_Smoe ------------------------------------------------------Y IRAKg_e-2_Smoe ------------------------------------------------------- IRAKg_o_Smoe ------------------------------------------------------- IRAKg_v_Smoe ------------------------------------------------------- IRAKg_s_Smoe ------------------------------------------------------- IRAKg_q_Smoe ------------------------------------------------------- IRAKg_a-1_Smoe ------------------------------------------------------R IRAKg_a-2_Smoe ------------------------------------------------------R IRAKg_g_Smoe ------------------------------------------------------- IRAKg_u-2_Smoe ------------------------------------------------------- IRAKg_p_Smoe ------------------------------------------------------- IRAKg_b_Smoe AYNMYQAGDLESIVDKKLVQEEVNVVQFKRLLKVALWCIQHDANARPSMGKVVQM IRAKg_n-2_Smoe ------------------------------------------------------E IRAKg_k-1_Smoe ------------------------------------------------------R IRAKg_n-1_Smoe AYNMYQAGDMESIVDKKLVGEEVDFVQFKRLLKVALWCIQHDAHARPSMGKVVQM IRAKg_h_Smoe ------------------------------------------------------K IRAKg_k-2_Smoe ------------------------------------------------------R IRAKg_r-2_Smoe ------------------------------------------------------- IRAKg_m-1_Smoe ------------------------------------------------------N IRAKg_u-1_Smoe ------------------------------------------------------- IRAKg_c_Smoe ------------------------------------------------------G IRAKg_o-1_Smoe ------------------------------------------------------- IRAKg_m-2_Smoe ------------------------------------------------------N IRAKg_o-2_Smoe -------------------------------------------------------