CLUSTAL W (1.83) multiple sequence alignment KSR2_Hsap LEI-GELIGKGRFGQVYHGRWHGEVAIRLIDIERDN--EDQLKAFKREVMAYRQTRHENV KSR1_Hsap VEL-GEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHN--QDHLKLFKKEVMNYRQTRHENV ksr-1_Cele FDKQAPIIGRGRFGKVLRGFHYGDVAVKVYTMEHISDASKKAEEFKLEVSAYKNTRHDNI KSR1_Spur ------------------------------------------------------------ KSR2_Spur LKY-GRCIEKGKLGSTYKGHWHGEVLIQT---RYSK--STDINDFLDEVAMLSKIRHENI KSR1_Mmus VEL-GEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHN--QDHLKLFKKEVMNYRQTRHENV KSR2_Mmus LEI-GELIGKGRFGQVYHGRWHGEVAIRLIDIERDN--EDQLKAFKREVMAYRQTRHENV ksr_Dmel LLL-LERIGQGRFGTVHRALWHGDVAVKLLNEDYLQ-DEHMLETFRSEVANFKNTRHENL AqueK675_Aque -----------------------------------R--QEDVRSFANEVNTLCCIRHENI AqueK676_Aque LKL-LEKLGSGPVAEVYKGYWHGEVAVKRFVLPNAT--PKQINKFREEVAVLKKIRHENL KSR2_Hsap VLFMGACMSPP---HLAIITSLCKG-RTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLH KSR1_Hsap VLFMGACMNPP---HLAIITSFCKG-RTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLH ksr-1_Cele ALFLGYFMSDG---QYGMVMSLSKGSQSLYTLLHVVREKLDLATTRKIAQQICQAVSYLH KSR1_Spur ---------------------LCKG-QTLYTHIHLRKDRFNINRTIQIATQITQGMSYLH KSR2_Spur ALFMGACVEPG---NLAVVNSIHKG-PSLYHHLHVQRRKLQTSSKMDIARQIGQAMGYLQ KSR1_Mmus VLFMGACMNPP---HLAIITSFCKG-RTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLH KSR2_Mmus VLFMGACMSPP---HLAIITSLCKG-RTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLH ksr_Dmel VLFMGACMNPP---YLAIVTSLCKG-NTLYTYIHQRREKFAMNRTLLIAQQIAQGMGYLH AqueK675_Aque QLFMGVCLDLPAGDTFGIIMSEVKG-DTLYNHIHKLGHNFTTPSKLKILRQISEGMEYLH AqueK676_Aque ALFMGVCLTTP---NLAIITSYCKG-YTLYKLLHYWSEAFSLERLANIGRQIAQAMGYLH ** :*: :: : * :* :.: **: KSR2_Hsap AKGILHKDLKSKNVFYDN----GKVVITDFGLFSISGVLQAGR--REDKLRIQNGWLCHL KSR1_Hsap AKGIVHKDLKSKNVFYDN----GKVVITDFGLFGISGVVREGR--RENQLKLSHDWLCYL ksr-1_Cele TKKILHKDLRSKNILLESK---NKVVITDFGILSMKRLAHPKQ--KSG-YLTSKFWTNYI KSR1_Spur HKGIVHKDLKSKNIFIEN----GKVVLTDFALFSIGRLSKQKT--RKDSLVIPDGWLCYL KSR2_Spur AKGIIVGHLSSRCVYLESK---VKLSVTRVDT---SDV--TCQ--RASHACLPRGKLQYL KSR1_Mmus AKGIVHKDLKSKNVFYDN----GKVVITDFGLFGISGVVREER--RENQLKLSHDWLCYL KSR2_Mmus AKGILHKDLKSKNVFYDN----GKVVITDFGLFSISGVLQAGR--RDDKLRIQNGWLCHL ksr_Dmel AREIIHKDLRTKNIFIEN----GKVIITDFGLFSSTKLLYC-----DMGLGVPHNWLCYL AqueK675_Aque AKGIQHGGLSSKLVTINHR----VCISLSFH------------NT--NNRQLEGCDLPYL AqueK676_Aque ARGIIHKGLNTKNIFLEKRDQKEKVIITDMGLSSLSSLLYDNTTSKGGVVTFPRAQLYSL : * * :: : : . : KSR2_Hsap APEIIRQLSPDTE---EDKLPFS--KHSDVFALGTIWYELHAREWPFKTQP------AEA KSR1_Hsap APEIVREMTPGKD---EDQLPFS--KAADVYAFGTVWYELQARDWPLKNQA------AEA ksr-1_Cele APELAMAMRTEYDEYECDDFPFS--ENSDVYAFGCVWFEMLTGALPYAGEL------PHQ KSR1_Spur APELITSLKINTDGTQDMELPFS--EKSDVYSFGTIWYELLAGEWPFHKQP------VET KSR2_Spur APELLAKARVVPPE-FITGNEQT--HSTDVYAFGTILFEIIAGRWPLQYAC------SES KSR1_Mmus APEIVREMIPGRD---EDQLPFS--KAADVYAFGTVWYELQARDWPFKHQP------AEA KSR2_Mmus APEIIRQLSPDTE---EDKLPFS--KHSDVFALGTIWYELHAREWPFKTQP------AEA ksr_Dmel APELIRALQPEKP--RGECLEFT--PYSDVYSFGTVWYELICGEFTFKDQP------AES AqueK675_Aque TPEEIRSITQLSNGYLFLPTKPT--PSTDIFAFGTIAYELTTLKLPFLNQS------LLD AqueK676_Aque APEIIRKISPTPVV-QIDQEPYSYNYATDVYAFGTILYELITKRFPFSTDSLGFAYEFEV :** : :*::::* : :*: . KSR2_Hsap IIWQMGT--GMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLM-------------- KSR1_Hsap SIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLM-------------- ksr-1_Cele ILFAKTQ--GIRPVLPNVKCTQELKELLVSCWNTAPQDRPTLTDINLKLTALPKKP-RV- KSR1_Spur VIWQVGK--GLKQPLNHLQASRDVKEILMMCWSYSPDSRPIFQHIKK------------- KSR2_Spur VIYQTCS--GRRDDFRNVTCSSTMKNLIQECWSQNPNERPSFQDIVKELKKNVSLG---- KSR1_Mmus LIWQIGSGEGVRRVLASVSLGKEVGEILSACWAFDLQERPSFSLLM-------------- KSR2_Mmus IIWQMGT--GMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLM-------------- ksr_Dmel IIWQVGR--GMKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFARLLS------------- AqueK675_Aque LIWSVGN--NGHQSLKLLP-RSCFRSVIHRCWSHT--RRTTFKDILSSI----------- AqueK676_Aque VIFLVGH--GHRQPFKG-ETPKKLKDIVWECWSHQPQDRPPFSDLQERLARLCRKHTPIT :: . : : . .:: ** *. : : KSR2_Hsap ------------DM KSR1_Hsap ------------DM ksr-1_Cele --------NRSPSF KSR1_Spur ------------TI KSR2_Spur -------NMKHSLS KSR1_Mmus ------------DM KSR2_Mmus ------------DM ksr_Dmel ------------LL AqueK675_Aque ------------QD AqueK676_Aque RSPSHPINLSKSVD