CLUSTAL W (1.83) multiple sequence alignment LZK_Hsap ISELQWLGSGAQGAVFLGKFRAEE-----------------VAIKKVRE----------- CG8789_Dmel ITELEWLGSGAQGAVFSGRLKNET-----------------VAVKKVKE----------- LZK_Mmus ISELQWLGSGAQGAVFLGKFRAEE-----------------VAIKKVRE----------- DLK_Mmus ILDLQWVGSGAQGAVFLGRFHGEE-----------------VAVKKVRD----------- F33E2.2_Cele ISELEWLGSGSQGAVFRGQLENRT-----------------VAVKKVNQ----------- DLK_Hsap ILDLQWVGSGAQGAVFLGRFHGEE-----------------VAVKKVRD----------- LZK_Spur IRNLQWLGSGAQGAVFLGWYRTEP-----------------VAVKKVRD----------- AqueK651_Aque ------------------------------------------------------------ AqueK652_Aque LEFYEKLGGGAAGSVYRAKWKSKD---------------KIVAVKKLL------------ AqueK653_Aque ---------------YSGSFRRTK-----------------VGVKCLRKVR--------- AqueK654_Aque IYRHDVLGRGSYGYVCRAKADQLD-----------------CAAKMINPIFFEIGGSPGR AqueK655_Aque IRELSYIGKGGQGAVFSGKYRDNE-----------------VAVKKVND----------- AqueK656_Aque LQILDELGHGRFGKIFLAGTVNVSLKDLKLNEDTDRNKSILVAMKQLKP----------- AqueK657_Aque --------SKLYAVKLIFNFTD-----------------DDYSSSVLS------------ LZK_b-1_Smoe LEEIRELGSGTFGTVYHGKWRGTD-----------------VAIKRIKASCFF--GPP-- LZK_b-2_Smoe LEEIRELGSGTFGTVYHGKWRGTD-----------------VAIKRIKASCFF--GPP-- LZK_a-2_Smoe LEEIRELGSGTYGTVYHGKWRGTD-----------------VAIKRIKASCFE--GRP-- LZK_a-1_Smoe LEEIRELGSGTYGTVYHGKWRGTD-----------------VAIKRIKASCFE--GRP-- LZK_Hsap ------------QNETDIKHLRKL-KHPNIIAFKG------------VCTQAPC------ CG8789_Dmel ------------LKETDIKHLRKL-DHENIIKFKG------------VCTQSPV------ LZK_Mmus ------------QNETDIKHLRKL-KHPNIIAFKG------------VCTQAPC------ DLK_Mmus ------------LKETDIKHLRKL-KHPNIITFKG------------VCTQAPC------ F33E2.2_Cele ------------LKETEIKHLRHL-RHQNIIEFLG------------VCSKSPC------ DLK_Hsap ------------LKETDIKHLRKL-KHPNIITFKG------------VCTQAPC------ LZK_Spur ------------EKETDIKHLRKL-NHPNIVTIKG------------VCTLAPC------ AqueK651_Aque ------------------------------------------------------------ AqueK652_Aque ------------ELEKEAEVLSSL-SHRNVVQFFG------------AVITKPN------ AqueK653_Aque -S--------FEDYRKAMSLNSKL-HHPNIVLFIG------------ATTV-ED------ AqueK654_Aque EELENPERAITGRFLAECELLRSLPSHPNIVQFIG------------VCRIAEEM----- AqueK655_Aque ------------PKQTELKILRKL-SHPNIVKCLG------------VCNKPPC------ AqueK656_Aque --EAS--PELRDAFNQEIKFMSHL-QHANVVRLLA------------VSLTDES------ AqueK657_Aque -----------NHFENEWLLLSSLPPHPQIIKYWCQFVSVIPMEFVECCPQEVCKSFPKD LZK_b-1_Smoe --SEQ--DRLKDDFWSEACILAHL-HHPNVVAFYG------------VVPDSPGG----- LZK_b-2_Smoe --SEQ--DRLKDDFWSEACILAHL-HHPNVVAFYG------------VVPDSPGG----- LZK_a-2_Smoe --VER--DRLILDFWREAGTLSKL-HHPNVVAFYG------------VVPDGPGG----- LZK_a-1_Smoe --VER--DRLILDFWREAGTLSKL-HHPNVVAFYG------------VVPDGPGG----- LZK_Hsap ----------YCIIMEYCAHGQLYEVLRA-----------G--------------RKITP CG8789_Dmel ----------FCIIMEFCPYGPLQNILKE-----------E--------------QVMLP LZK_Mmus ----------YCIIMEYCAHGQLYEVLRA-----------G--------------RKITP DLK_Mmus ----------YCILMEFCAQGQLYEVLRA-----------G--------------RPVTP F33E2.2_Cele ----------YCIVMEYCSKGQLCTVLKS-----------R--------------NTITR DLK_Hsap ----------YCILMEFCAQGQLYEVLRA-----------G--------------RPVTP LZK_Spur ----------FCILMEYCPFGQLYEVLRD-----------G--------------REIPP AqueK651_Aque ------------------------------------------------------------ AqueK652_Aque ----------YCLVTEYAELGSLYEYLR--S---------N---------------TIDF AqueK653_Aque ----------YIIVTEFSSFKALNIHLE--E------------------------APLSR AqueK654_Aque ----RGGEYGPVLLTELMST-TLWDYVSSKS---------RDFTPKSRDRAPIRPDYIPR AqueK655_Aque ----------YCIVMEYCRLGNLFDYIRKT----------S--------------TKIMP AqueK656_Aque ----------PFIVIEYMENGDLHQFLRQLELQPNSATVSS--------------DHISP AqueK657_Aque KHFTRK---GQFIVLDYHPQ-TLQEFLTKEE---------N--------------KPVDF LZK_b-1_Smoe ---------TLATVTEFMVNGSLKQVLHKK----------E--------------RILDR LZK_b-2_Smoe ---------TLATVTEFMVNGSLKQVLHKK----------E--------------RILDR LZK_a-2_Smoe ---------TLATVTEYMVNGSLKQVLQKK----------D--------------RTIDR LZK_a-1_Smoe ---------TLATVTEYMVNGSLKQVLQKK----------D--------------RTIDR LZK_Hsap RLLVDWSTGIASGMNYLHLH---KIIHRDLKSPNVLVTHTD------AVKISDFGTSKEL CG8789_Dmel SRLVSWSKQIALGMQYLHSH---KIIHRDLKSPNILISTNE------VVKISDFGTSREW LZK_Mmus RLLVDWSTGIASGMNYLHLH---KIIHRDLKSPNVLVTHTD------AVKISDFGTSKEL DLK_Mmus SLLVDWSMGIAGGMNYLHLH---KIIHRDLKSPNMLITYDD------VVKISDFGTSKEL F33E2.2_Cele ELFAQWVKEIADGMHYLHQN---KVIHRDLKSPNILISAED------SIKICDFGTSHMQ DLK_Hsap SLLVDWSMGIAGGMNYLHLH---KIIHRDLKSPNMLITYDD------VVKISDFGTSKEL LZK_Spur QLMIDWSKQIAQGMHYLHIH---KIIHRDLKSPNVLVANND------ILKISDFGTSREW AqueK651_Aque ---------VACALNYLHLFKPHPIIHRDISSGNVLLQPTSHMGIGWRAKVSDYGSANLQ AqueK652_Aque NQIRLWAKQIAMGMNYLHFEAPIPVIHRDLKSRNVVIAQD------LTAKICDFGSSKF- AqueK653_Aque NHILSLAKDVACGLAYLHLH-PTPITHGSLSSHTVLLEPKGNG---WKGKITDIGFFPYM AqueK654_Aque TTQVKIMKDIAVALSFLHDR---DILHRDLSSKNVLMK-DD------APKISDLGMAKLR AqueK655_Aque FDVIQWSREICTGMQFLHSK---KLIHRDLKSLNVLVSDNH------SMKITDFGVSRTL AqueK656_Aque VILLYITVQIASGMRYLANK---RFVHRDLAARNILVGRDF------VTKISDFGMSRSL AqueK657_Aque KIILSISSQILSAASYLESN---MICHLDLKLANCLVRGEEED--NPHIVLCDFGSAVQF LZK_b-1_Smoe RRRLLVAMDAAFGMEYLHDK---KIIHFDLKGENLLVNMRDSQ--KPVCKVGDLGLSKIK LZK_b-2_Smoe RRRLLVAMDAAFGMEYLHDK---KIIHFDLKGENLLVNMRDSQ--KPVCKVGDLGLSKIK LZK_a-2_Smoe RKRLLIATDAAFGMEYLHGK---NIVHFDLKCENLLVNMRDPH--RPVCKVGDLGLSKVK LZK_a-1_Smoe RKRLLIATDAAFGMEYLHGK---NIVHFDLKCENLLVNMRDPH--RPVCKVGDLGLSKVK . :* . * .: . :: : * * LZK_Hsap SD-KSTK-------MSFAGTVAWMAPEVIRNEP------------------------VSE CG8789_Dmel NE-ISTK-------MSFAGTVAWMAPEVIRNEP------------------------CSE LZK_Mmus SD-KSTK-------MSFAGTVAWMAPEVIRNEP------------------------VSE DLK_Mmus SD-KSTK-------MSFAGTVAWMAPEVIRNEP------------------------VSE F33E2.2_Cele KKMDSTM-------MSFCGTVSWMAPEMIKKQP------------------------CNE DLK_Hsap SD-KSTK-------MSFAGTVAWMAPEVIRNEP------------------------VSE LZK_Spur NE-KSTK-------MSFAGTVAWMAPEVIRNEP------------------------CSE AqueK651_Aque N-LI-AT-------TENPGNQIYSAPEAGNPRE------------------------HSP AqueK652_Aque HK-HTTQ-------MSLVGTFPWMAPE--------------------------------- AqueK653_Aque A-TP---------------LSAYAAPEAMDSDS------------------------LSP AqueK654_Aque DV-TKSL-------TTCPGTPIFMAPEALLNNP-----------------------AYST AqueK655_Aque DH-QFTK-------MTVIGSVAWMAPELIRSEP------------------------CSE AqueK656_Aque YE-SSYYCV----AGQLILPIRWMSTETYYGQ-------------------------FSV AqueK657_Aque SD-STMS-TQWCHGLSLGGNRAHLCPELLSQYYSYKTSTSRLQQPSAAPISLAQRLLCYK LZK_b-1_Smoe HK-TMVT-------GGVRGTLPWMAPELLNGRS----------------------ISVSE LZK_b-2_Smoe HK-TMVT-------GGVRGTLPWMAPELLNGRS----------------------ISVSE LZK_a-2_Smoe RQ-TMVS-------GGVRGTLPWMAPELLSTSS----------------------CMVSE LZK_a-1_Smoe RQ-TMVS-------GGVRGTLPWMAPELLSTSS----------------------CMVSE ..* LZK_Hsap K-VDIWSFGVVLWEL--LT-GEIPYKDVDSSAIIWGVGS---NSLHLPVPSTCPDGFKIL CG8789_Dmel K-VDIWSYGVVLWEM--LT-CEIPYKDVDSSAIIWGVGN---NSLKLLVPSTCPEGFKLL LZK_Mmus K-VDIWSFGVVLWEL--LT-GEIPYKDVDSSAIIWGVGS---NSLHLPVPSTCPDGFKIL DLK_Mmus K-VDIWSFGVVLWEL--LT-GEIPYKDVDSSAIIWGVGS---NSLHLPVPSSCPDGFKIL F33E2.2_Cele K-VDVYSFGVVLWEM--LT-RETPYANIAQMAIIFGVGT---NILSLPMPEEAPKGLVLL DLK_Hsap K-VDIWSFGVVLWEL--LT-GEIPYKDVDSSAIIWGVGS---NSLHLPVPSSCPDGFKIL LZK_Spur K-VDVWSFGVVLWEL--LT-GEMPYKDVDSSAIIWGVGS---NSLQLPIPSTCPEGFKLL AqueK651_Aque A-MDVFSYGVLLIE---------------------------------------------- AqueK652_Aque ------------------------------------------------------------ AqueK653_Aque S-LDIYGYGVLLIEM--YC-RKAL-----------GTS--GSER-DKQLQHINWPQFVTL AqueK654_Aque K-LDIFSWGVISLQV--MS-GQE------------------------------------- AqueK655_Aque K-VDIWSFGVCLWEL--LT-REEPYKDLNHGAVIYGVGS---TTLSLPIPTGCPSDLKSL AqueK656_Aque K-SDSWAFGVTVWEVFMLC-RSLPYSHLQDDEVIADAVK-GEEREVLQKPESCPTEVYAV AqueK657_Aque G-QPSFAVGVLLYEV--GSCGEHPLPDYPLNYMKEGVVTYGESDIAELPGAYCHQQYFDL LZK_b-1_Smoe K-VDVFSFGIVMWEL--LT-GEEPYADLHYGAIIGGIVS---NQLRPQVPSSCDPEWQSL LZK_b-2_Smoe KVVDVFSFGIVMWEL--LT-GEEPYADLHYGAIIGGIVS---NQLRPQVPSSCDPEWQSL LZK_a-2_Smoe R-VDVFSFGIVMWEL--LT-GEEPYANMHYGAIIGGIVS---NTLRPPIPNWCEPAWRSL LZK_a-1_Smoe R-VDVFSFGIVMWEL--LT-GEEPYANMHYGAIIGGIVS---NTLRPPIPNWCEPAWRSL LZK_Hsap MKQTWQSKPRNRPSFRQTLMH--L CG8789_Dmel VKLCWKSKPRNRPSFRQILSH--L LZK_Mmus MKQTWQSKPRNRPSFRQTLMH--L DLK_Mmus LRQCWNSKPRNRPSFRQILLH--L F33E2.2_Cele IKQCLSQKGRNRPSFSHIRQH-WE DLK_Hsap LRQCWNSKPRNRPSFRQILLH--L LZK_Spur MMQCWSAKTRNRPSFRQILMHIDI AqueK651_Aque -----------------------M AqueK652_Aque -----------------------H AqueK653_Aque IQSCLSVEPADRPLVNDI-----L AqueK654_Aque -----------------------P AqueK655_Aque LQKCWQQKPKSRPSFSQIIEE--L AqueK656_Aque LRRCFVHSPQVRADFEEIYSRLFV AqueK657_Aque LKSLIACDPKQRPNLEHTL----D LZK_b-1_Smoe MERCWADDPAVRPTFPAIVGE--L LZK_b-2_Smoe MERCWADDPAVRPTFPAIVGE--L LZK_a-2_Smoe MERCWDADPSARPSFAEIASE--L LZK_a-1_Smoe MERCWDADPSARPSFAEIASE--L