CLUSTAL W (1.83) multiple sequence alignment M04C9.5_Cele YLMTKRLGDGTFGEVMLAKKI--------------------------------------- DDB0229430_Ddis YQFIKQVGDGAYGDVIKAIDV--------------------------------------- MAK_Hsap YTTMRQLGDGTYGSVLMGKSN--------------------------------------- ICK_Hsap YTTIRQLGDGTYGSVLLGRSI--------------------------------------- CG4588_Dmel YITLTQLGDGTYGTVVLGQRK--------------------------------------- ICK_Mmus YTTIKQLGDGTYGSVLLGRSI--------------------------------------- MAK_Mmus YTTMKQLGDGTYGSVLMGKSN--------------------------------------- IME2_Scer YQLIEKLGAGSFGCVTLAKAQFPLSN---------ILGKQHDIRGTLMDQPKNGHQNYIT MAK_Spur YQVTKQLGDGTYGSVILGCRF--------------------------------------- CC1G_11298_Ccin YTPIKVLGDGSFGTVWLCDWHTTLPPNTPLSPMQCGQG-----------------ARPEW AqueK132_Aque YTFLKVLGDGTFGVVSLAKEK--------------------------------------- MAK_d_Smoe YKVIKQLGDGTYGTVWKAVNK--------------------------------------- MAK_c_Smoe YKVIKQLGDGTYGTVWKAVNK--------------------------------------- MAK_e_Smoe YQVIKQVGDGTYGSVWKAIDR--------------------------------------- MAK_b_Smoe IDYSTRLGRGTGGTVREGINL--------------------------------------- MAK_a_Smoe YQVIKQVGDGTYGSVWKAIDR--------------------------------------- GK041_Glam YTVITELGSGNYGTVYKAREN--------------------------------------- GK039_Glam YTPVRRVGSGTYGDVLHAVD---------------------------------------- :* * * * M04C9.5_Cele DTGDRVAIKRMKKKFY-SWEEAMSLREVK-------------------SLKKL-NHPNII DDB0229430_Ddis KTGEIVAIKRMKKKFS-DWKECIQLREIK-------------------ALKKL-KHPNIV MAK_Hsap ESGELVAIKRMKRKFY-SWDECMNLREVK-------------------SLKKL-NHANVI ICK_Hsap ESGELIAIKKMKRKFY-SWEECMNLREVK-------------------SLKKL-NHANVV CG4588_Dmel DTGEKVAIKRMKRKYY-SWEEAMNLREVK-------------------SLKKL-SHPNIV ICK_Mmus ESGELIAIKKMKRKFY-SWEECMNLREVK-------------------SLKKL-NHANIV MAK_Mmus ESGELVAIKRMKRKFY-SWDECMNLREVK-------------------SLKKL-NHANVI IME2_Scer KTQGVVAIKTMMTKLH-TLQDYTRVREIK-------------------FILAIPANDHLI MAK_Spur DNGEKVAIKKMKKKFY-SWNECMELREVK-------------------SLKKL-NHANIV CC1G_11298_Ccin AGKRLVAVKRMKKRWEGGWDECQKLKELE-------------------SLRAIPFHPNII AqueK132_Aque ETGNMVAIKKMKQDFL-SWEECLKLKEVQVSELFVSPYIYKYGRNDVHALQRL-KHVNII MAK_d_Smoe VTNETVAIKKMKRKYL-SWDECMNLREVK-------------------SLRKL-NHPNIV MAK_c_Smoe VTNETVAIKKMKRKYL-SWDECMNLREVK-------------------SLRKL-NHPNIV MAK_e_Smoe CTNEFVAIKKMKTKFH-GWEECMNLREVK-------------------CLQRL-DHPNIV MAK_b_Smoe DTMEKVAIKEMVEHLN-LHEETKLV---Y------------------GLLQEC-QHENIV MAK_a_Smoe CTNEFVAIKKMKTKFH-GWEECMNLREVK-------------------CLQRL-DHPNIV GK041_Glam KKGTLVAIKHMKQKYK-SWSECVTLKEVK-------------------SLIRMKEHPNIV GK039_Glam TKGDFVAIKIMNSHTL-CVSDPLQLPEVA-------------------TLRRLPPHPNII :*:* * .: : : : ::: M04C9.5_Cele KLREVI--RENDILYFVFEFM----------------QE-NLYELMK-DRD----RYFPE DDB0229430_Ddis KLLEII--LERDELFFVFEYL----------------EN-NLYESIK-DRT----KLLPE MAK_Hsap KLKEVI--RENDHLYFIFEYM----------------KE-NLYQLMK-DRN----KLFPE ICK_Hsap KLKEVI--RENDHLYFIFEYM----------------KE-NLYQLIK-ERN----KLFPE CG4588_Dmel KLKEVI--RENDTLYFVFEYM----------------KE-NLYQMIK-DRD----THLPE ICK_Mmus KLKEVI--RENDHLYFIFEYM----------------KE-NLYQLIK-ERN----KLFPE MAK_Mmus KLKEVI--RENDHLYFVFEYM----------------KE-NLYQLMK-DRN----KLFPE IME2_Scer QIFEVFIDSENYQLHIVMECM----------------EQ-NLYQMMK-HRRR---RVFSI MAK_Spur KLKEVI--REDNILYFVFEYM----------------TE-NLYELMK-GRD----RLLPE CC1G_11298_Ccin PLYDFFLLPTSKELYFVFESM----------------EG-NLYHLIK-ARKG---RPLAG AqueK132_Aque KATEIF--RDNNTLYFVFEYM----------------RQ-NLYELIK-SRGS---NLFPE MAK_d_Smoe KLKEVI--RENNELFFVFEYMVLYFCFPFSATHFYLQEC-NLYQMMK-DRQ----KLFPE MAK_c_Smoe KLKEVI--RENNELFFVFEYMVLYFCFPFSATHVYLQEC-NLYQMMK-DRQ----KLFPE MAK_e_Smoe QLKEVI--WEHGELFLVFEYM----------------EC-NLYQVMK-DRS----KMLSE MAK_b_Smoe KLLDVG--SIGGKTYMVFEHM----------------FG-DLYKFKK-RLGMLMKRTLNR MAK_a_Smoe QLKEVI--WEHGELFLVFEYM----------------EC-NLYQVMK-DRS----KMLSE GK041_Glam KLMEVV--RQKEDLYFVFEYI----------------NSGNLFDFVVQQRSAG--IKISE GK039_Glam RLIRVV--VTRDHTHLIFEYA----------------GGGTLLNFLR-S-SG----PLKE . .:::* * . : M04C9.5_Cele SVIRNIIYQVLQGLAFMHKNGFFHRDMKPENIMCNG------------------------ DDB0229430_Ddis TTIRNIIYQILQALHFMHTNGFFHRDLKPENIMLV------------------------- MAK_Hsap SVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMG------------------------ ICK_Hsap SAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMG------------------------ CG4588_Dmel PELKSILFQVLTGLAFMHRHGFFHRDLKPENLLCSG------------------------ ICK_Mmus SAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMG------------------------ MAK_Mmus SVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMG------------------------ IME2_Scer PSLKSILSQILAGLKHIHEHNFFHRDLKPENILITPSTQYFEKEYMNQ----IG---YQD MAK_Spur PVIRNIVYQILQGMAYIHKNGFFHRDMKPENLLCCG------------------------ CC1G_11298_Ccin GLVSSIFQQITLGLDHIHTHGYFHRDMKPENVLVTTVGLF-DYTPVSPIAPPNAPKERDV AqueK132_Aque HVVRNISYQIIQAVSYMHSQGLFHRDLKPENILCQG------------------------ MAK_d_Smoe AKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVT------------------------- MAK_c_Smoe AKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVT------------------------- MAK_e_Smoe ERIRIWSFQVLRALDYMHQHGIFHRDLKPENLLVS------------------------- MAK_b_Smoe EEIKTIIEQILQALAYMHEHGIVHQDIKTANVLINKE----------------------- MAK_a_Smoe ERIRIWSFQVLRALDYMHQHGIFHRDLKPD------------------------------ GK041_Glam LVAKDLVRQILEGLEHIHRNNYMHRDLKCENILVSDDG--------------------TG GK039_Glam HMLRNIAFRILQGLYHIHTNSVIHRDLKLENILLTSETGD-----------------ANG :: .: .:* .. .*:*:* M04C9.5_Cele -TELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEILLRST-SYNSPIDMWALGCIMAEL DDB0229430_Ddis -GERLKIADFGLAREIESKPPFTDYISTRWYRAPEVLLRCT-YYNAPIDIWAVGAIMAEL MAK_Hsap -PELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSS-VYSSPIDVWAVGSIMAEL ICK_Hsap -PELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRST-NYSSPIDVWAVGCIMAEV CG4588_Dmel -PDLIKIADFGLAREIRSRPPFTDYVSTRWYRAPEVLLHST-NYGSTIDLWAMGCIMAEL ICK_Mmus -PELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRST-NYSSPIDIWAVGCIMAEV MAK_Mmus -PELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSS-VYSSPIDVWAVGSIMAEL IME2_Scer -NYVIKLADFGLARHVENKNPYTAYVSTRWYRSPEILLRSG-YYSKPLDIWAFGCVAVEV MAK_Spur -PELIKIADFGLARETRSRPPYTDYVSTRWYRAPEVLLRST-KYSSPIDMWAVGCIMAEL CC1G_11298_Ccin -VTIIKLADFGLARETRSRPPYTEYVSTRWYRAPEVLLLSR-EYSNPVDLWALGTIMAEL AqueK132_Aque -HELIKLADFGQAREIRSRPPYTDYVSTRWYRAPEVQLGSK-NYNSPIDIWAVACIMSEV MAK_d_Smoe -VDVIKIADFGLAREVRSRPPYTNYVSTRWYRAPEVLLQSS-LYNSAVDMWAMGAIMAEL MAK_c_Smoe -VDVIKIADFGLAREVRSRPPYTNYVSTRWYRAPEVLLQSS-LYNSAVDMWAMGAIMAEL MAK_e_Smoe -DEAIKVADFGLAREVYSVAPYTDYVATRWYRAPEVLLQAP-SYSYAIDIWAMGAIMAEL MAK_b_Smoe -GTKVKLCDFDHARRVTTPPRDPETIGTLAYNAPEIILGDTQELGSGVDVWGAGVILAEL MAK_a_Smoe ------------------------------------------------------------ GK041_Glam -TRCVKIADLGCAKSLLERPPHTVYVGTRWYRAVELFLKDS-SYSAKNDIWACACILCEI GK039_Glam DIVGVKIADFGLSRAQGSRQ-NTDYVSTRWYRAPELLLHYS-GYGPPIDIWAAGCCFAEL M04C9.5_Cele YILRPLFPGTSE---MDQLFKIISILGTPNKD-----------------EWPEGYQLASA DDB0229430_Ddis YSLKPMFPGSSE---IDQLFKICTIMGSPTSA-----------------TWIDGIKLANS MAK_Hsap YMLRPLFPGTSE---VDEIFKICQVLGTPKKS-----------------DWPEGYQLASS ICK_Hsap YTLRPLFPGASE---IDTIFKICQVLGTPKKT-----------------DWPEGYQLSSA CG4588_Dmel YTFRPLFPGSSE---VDQLFKICSVLGTPDKD-----------------DWPDGYRLASM ICK_Mmus YTLRPLFPGASE---IDTIFKICQVLGTPKKT-----------------DWPEGYQLSSA MAK_Mmus YTFRPLFPGTSE---VDEIFKICQVLGTPKKS-----------------DWPEGYQLASS IME2_Scer TVFRALFPGANE---IDQIWKILEVLGTPIKRSDFVN-TNHITAPPPGGFWDDASNLVHK MAK_Spur YTLRPLFPGSSE---VDEIFKITTVLGTPKKE-----------------EWVEGFRLASQ CC1G_11298_Ccin VNLRPLFPGSDQ---VDQVARVCEVLGDPAEDY--RDNGGNVV---GGGQWPHGVSLARD AqueK132_Aque YSGRPLFPGSGT---IDQVYKICGVLGTPTKA-----------------TWGEGVGLAVS MAK_d_Smoe FNLRPIFPGASE---ADEIYKICSVLGNPSQA-----------------TWPDGMKLAKC MAK_c_Smoe FNLRPIFPGASE---ADEIYKICSVLGNPSQA-----------------TWPDGMKLAKC MAK_e_Smoe FNLQPLFPGASE---ADEIYKICSVLGSPNYH-----------------TWPDGMQLAVR MAK_b_Smoe VLGYNPFSVVRESHAARELYRVVEEIKE-------------------------------- MAK_a_Smoe ------------------------------------------------------------ GK041_Glam LLMKPLFPGAND---IDMLNLITSTLGSPTRE-----------------DWPAGYALAER GK039_Glam LTGDPLFPGDTE---IQQLQLICAFLK-PLKP-----------------DACKGAMHA-- M04C9.5_Cele MNFRFQQVVAT-------PMEQVVNT---------ISKEGMKLMMDMMLWNPEKRPNANQ DDB0229430_Ddis MGFTFPNVQPPSIN----PLSTLLPN---------ANQDAIELITDLLQYDPLKRPTPLQ MAK_Hsap MNFRFPQCVPI-------NLKTLIPN---------ASNEAIQLMTEMLNWDPKKRPTASQ ICK_Hsap MNFRWPQCVPN-------NLKTLIPN---------ASSEAVQLLRDMLQWDPKKRPTASQ CG4588_Dmel IHFRYPDCIKV-------PLSSVVSR---------CSQNGLDLLEDMLAYDPDKRPTAQQ ICK_Mmus MNFLWPQCIPN-------NLKTLIPN---------ASSEAIQLLRDLLQWDPKKRPTASQ MAK_Mmus MNFRFPQCIPI-------NLKTLIPN---------ASSEAIQLMTEMLNWDPKKRPTASQ IME2_Scer LNLKLPYVEGS-------SLDHLLSS--------SQLSDLSEVVKKCLRWDPNERATAQE MAK_Spur MNFKFPQCVAM-------PLKTIIPN---------ASPESIHLIRDMLLWDPQKRPTAAQ CC1G_11298_Ccin VGFQFPRIEPK-------DIFSLFDA--------SVPRSLIQCIRDLLRWDPAKRLTSKQ AqueK132_Aque MSIRLPIMVPT-------PLSALVPT---------ASDDGISVMKEMLQWNPRRRPTAKQ MAK_d_Smoe MNFRFPQ--------------------------------------AMFAWDPLKRPTPSQ MAK_c_Smoe MNFRFPQFVPA-------NLSALVPS---------ASAEAIDLMKAMFAWDPLKRPTPSQ MAK_e_Smoe KGFRFPQFAPA-------GLQSLIPS---------ASPAAVDMISAMLCWDPNRRPTAYQ MAK_b_Smoe ------------------RLH---RE--------IGDEDILELLDNMLVWEPEERWSAER MAK_a_Smoe ------------------------------------------------------------ GK041_Glam IGYKFPRATQSRQE----KLRYLFPN---------VTEDCINLLSRMFEFDQNKRLSAQD GK039_Glam ----LPRFITENMTVSDADIYTLAEAREALRRELGCSHVLADLLAHMLAWNPEDRITAQR M04C9.5_Cele SLRYKYF DDB0229430_Ddis ALQHRYF MAK_Hsap ALKHPYF ICK_Hsap ALRYPYF CG4588_Dmel SLKYPYF ICK_Mmus ALRYPYF MAK_Mmus ALKHPYF IME2_Scer LCEMPFF MAK_Spur CLKYKYF CC1G_11298_Ccin CLDHLYL AqueK132_Aque VLMHKYF MAK_d_Smoe ALQHPFF MAK_c_Smoe ALQHPFF MAK_e_Smoe LRQHPFF MAK_b_Smoe ALSSSFF MAK_a_Smoe ------- GK041_Glam CLRHPWF GK039_Glam ALMHQFF