CLUSTAL W (1.83) multiple sequence alignment MAST2_Hsap FETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPF MAST4_Hsap FETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPF MAST1_Hsap FDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPF MAST3_Hsap FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPF kin-4_Cele FDTIRLVSNGAYGAVYLVRHRETRQRFALKKMNKQTLMLRNQVDQVFAERDILTMADNPF 9978_Tthe FEFIKMLGKGAYGGVYLVKKKNTNDLFAMKVIDCSGKLDKKYLETLQSEKNVFEVITGDW 15619_Tthe FEFKRLLGVGAFGAVWLVNKKTTKDEYALKIIDCSQQMDRNQQDNLRAETNVFAILTGDH 19957_Tthe FEFVRHLGAGAYGGVYLVKKKSSGDLFAMKVIDCSGKLDKKYLESLQSERNVFEIITGDY MAST2_Spur FENIKIISNGAYGAVYLVRHKASLQRFAMKKICKQNIALRNQREQVFAERDILTFAENPF MAST1_Mmus FDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPF MAST2_Mmus FETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPF MAST3_Mmus FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPF MAST4_Mmus FETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPF DDB0185113_Ddis FEFIKPITKGGYGKVFLAKKIRTGDIYAIKRLKKSDMIKKNQLDHVKVERNILAYTSNPF DDB0216386_Ddis YYFIKPISKGGYGQVFLAITKS-NKFFAIKSINKRDTIGKHMVKELMVERNILVQYQNQS DDB0220700_Ddis FNFLKVISKGGFGKVYLAENKITKKTVAIKVIKKSDTIKKMMVDQVNIEKTILSNYKCNF DDB0220701_Ddis FEIIKPISRGAFGRVYLAQKKKTGDLYAIKVLKKLDTIRKNMVNHVIVERNILAMVQNEF DDB0229452_Ddis YKHVECIGKGGYGVVCKFINKKTNEIRAIKTIRKDYSA--------LKEINTLKELGGQF CG6498_Dmel FDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDILSFADNPF AqueK009_Aque FDVIKIISNGAYGAVYLVRHKQTRMRFAMKKVNKKRMIMKKQVQSVFNERDILTFSENPF MAST_c-2_Smoe FEIIKPISRGAFGRVFLARKRTTGDLFAIKVLRKADMIRKNAVESVHAERNILIHAKNPF MAST_b-2_Smoe FEIIKPISRGAFGRVFLARKKTTGDLFAVKVLRKSDMIRKNAVRSVQAERNILISARNPF MAST_b-1_Smoe FEIIKPISRGAFGRVFLARKKTTGDLFAVKVLRKSDMIRKNAVRSVQAERNILISARNPF MAST_c-1_Smoe FEIIKPISRGAFGRVFLARKRTTGDLFAIKVLRKADMIRKNAVESVHAERNILIHAKNPF : . : *.:* * *:* : * : MAST2_Hsap VVSMFCSFDT--KRHLCMVMEYVEGGDCATLLKNIG-ALPVDMVRLYFAETVLALEYLHN MAST4_Hsap VVSMYCSFET--RRHLCMVMEYVEGGDCATLMKNMG-PLPVDMARMYFAETVLALEYLHN MAST1_Hsap VVGMFCSFET--RRHLCMVMEYVEGGDCATLLKNIG-ALPVEMARMYFAETVLALEYLHN MAST3_Hsap VVSMFCSFET--RRHLCMVMEYVEGGDCATLLKNMG-PLPVDMARLYFAETVLALEYLHN kin-4_Cele VVSFYGSFET--RQYLCMLMEYVEGGDCAALLKSAG-TLPVELVRLYVAETILAIEYLHS 9978_Tthe VVKAFYSFVH--ENYLCFVLEYMMGGDFNKILSLYT-ALDQWIVEIYIAELVLAIEYLHS 15619_Tthe VVKALYSFQY--DNYLCFVLDYMSGGDFGQILRWYG-RLDESIAKFYLAEIILAIEYLHS 19957_Tthe VVKAFYSFVH--ETYLCFVLEYMVGGDFTHILEMYT-ALQEWIVQIYMAELILAVEYLHS MAST2_Spur VVALYCSFET--KKYLCMVMEYVEGGDVATLIKHIG-PLPLETARLYFAEAVLAIEYLHS MAST1_Mmus VVGMFCSFET--RRHLCMVMEYVEGGDCATLLKNIG-ALPVEMARMYFAETVLALEYLHN MAST2_Mmus VVSMFCSFET--KRHLCMVMEYVEGGDCATLLKNIG-ALPVDMVRLYFAETVLALEYLHN MAST3_Mmus VVGMFCSFET--RRHLCMVMEYVEGGDCATLLKNMG-PLPVDMARMYFAETVLALEYLHN MAST4_Mmus VVSMYCSFET--RRHLCMVMEYVEGGDCATLMKNMG-PLPVDMARMYFAETVLALEYLHN DDB0185113_Ddis VVKMYYSFQT--KEYYYLVMEYLQGGDCFSLLQMLG-SMDENMAKMIIAETVLALEYLHS DDB0216386_Ddis IVKLFECFQT--KKKLYMVMEFLHGGDCASLLHSLN-TLEEREAKNIIAQIVNGLEFIHS DDB0220700_Ddis IVELFSSFQT--DKKLFFVMEFLNGGDCASLLRSFNNNMPEDLTKNIIAQIIICLEYLHN DDB0220701_Ddis VVKLFYAFQS--TDKLYLVMEYLIGGDCASLLRALG-CFEEHMAKHYIAETVLCLEYLHK DDB0229452_Ddis TVNIFHTFLSPCKEKVLIEMEYLSGGDCAFHLNDVGVGFPEELAKQYTAETVLCLDFIHE CG6498_Dmel VVSMYCSFET--KKHLCLVMEYVEGGDCGTLLKNIG-PLPADMARFYFAETVLAVEYLHS AqueK009_Aque VVGLWCTFQT--RQHLYMVMEYVEGGDVAALLKGVG-YLTLELATMYFSETVLALEYIHS MAST_c-2_Smoe LVRFFYSFTC--KENLYLVMEYLNGGDMYSMLRNLG-CLDEDMARYYIAELVLALEYLHS MAST_b-2_Smoe VVRFFYSFTC--SENLYLVMEYLNGGDLYSLLMSMG-CLEEDMARVYIAELVLALEYLHS MAST_b-1_Smoe VVRFFYSFTC--SENLYLVMEYLNGGDLYSLLMSMG-CLEEDMARVYIAELVLALEYLHS MAST_c-1_Smoe LVRFFYSFTC--KENLYLVMEYLNGGDMYSMLRNLG-CLDEDMARYYIAELVLALEYLHS * * : :::: *** : : . :: : ::::*. MAST2_Hsap YGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIE-------------- MAST4_Hsap YGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIE-------------- MAST1_Hsap YGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIE-------------- MAST3_Hsap YGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIE-------------- kin-4_Cele YGIVHRDLKPDNLLITAMGHIKLTDFGLSKIGLMNRTTLVAEGYDA-------------- 9978_Tthe MDIVHRDLKPDNMLIDTTGHLKLADFGLSEVGFKTKLNKH-INKTDEDPSQQ-------- 15619_Tthe KGIIHRDLKPENVLLDKNGHIKLADFGLSEVGLTNKLNKKVIDETDPEVKK--------- 19957_Tthe QGIVHRDLKPDNILLDSKGHVKLADFGLSEVGFNQKLNRT-EKQKV-------------- MAST2_Spur YGIVHRDIKPDNMLITSTGHIKLTDFGLSKIGIMSLTTNLYEGNID-------------- MAST1_Mmus YGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIE-------------- MAST2_Mmus YGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIE-------------- MAST3_Mmus YGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIE-------------- MAST4_Mmus YGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIE-------------- DDB0185113_Ddis HGIVHRDVKPDNLLIDKKGHIKLTDFGLSKVGLLDRQTVVPPSYFSPTLS-GKNNQSSSS DDB0216386_Ddis CGIIHRDLKVENLIFDKNGIIKIVDFGFSEVGFTGNS----------------------- DDB0220700_Ddis HGIIHRDLKPDNILIDSNGHIKLADFGLSKFDFVDESCNIKILKN--------------- DDB0220701_Ddis SAIVHRDLKPDNMLIDGLGHIKLTDFGLSKIGIIDDKKMEDSGNTNTN------------ DDB0229452_Ddis KSIIHCDIKPNNMVIDSDGHIKLLDFGNAKK----------------------------- CG6498_Dmel YGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYID-------------- AqueK009_Aque HGIIHRDLKPDNLLITSEGHIKLTDFGLSKIGLTNYAAHVIEDAWA-------------- MAST_c-2_Smoe LAVIHRDLKPDNILIAHDGHIRLTDFGLSKVGLINSTDDLSAPASRGA------------ MAST_b-2_Smoe LGVVHRDLKPGNILIAHDGHIKLTDFGLSRMGLINSTDDLAI------------------ MAST_b-1_Smoe LGVVHRDLKPGNILIAHDGHIKLTDFGLSRMGLINSTDDLAI------------------ MAST_c-1_Smoe LAVIHRDLKPDNILIAHDGHIRLTDFGLSKVGLINSTDDLSAPASRGA------------ ::* *:* *::. * ::: *** :. MAST2_Hsap ------------------------------------------------------------ MAST4_Hsap ------------------------------------------------------------ MAST1_Hsap ------------------------------------------------------------ MAST3_Hsap ------------------------------------------------------------ kin-4_Cele ------------------------------------------------------------ 9978_Tthe ------GAGELVGINI-D-----EANKEN--------------------EFK--I----- 15619_Tthe -------------QKM-Y-----EQLRQD--------------------FGI-------- 19957_Tthe ------------AVDI-F-----GSKKDN--------------------ESKYKTEYQLL MAST2_Spur ------------------------------------------------------------ MAST1_Mmus ------------------------------------------------------------ MAST2_Mmus ------------------------------------------------------------ MAST3_Mmus ------------------------------------------------------------ MAST4_Mmus ------------------------------------------------------------ DDB0185113_Ddis SSVSNIGGSNTIGS------------------NISSTNNN-NNNNNTTGA---------- DDB0216386_Ddis ------------------------------------------------------------ DDB0220700_Ddis ------------------------------------------------------------ DDB0220701_Ddis -------------THFNFSTSPTNTSMMDDSST--TGN-PNGNGNTSLNS---------- DDB0229452_Ddis ------------------------------------------------------------ CG6498_Dmel ------------------------------------------------------------ AqueK009_Aque ------------------------------------------------------------ MAST_c-2_Smoe -------------A------------------V--------------------------- MAST_b-2_Smoe ------------------------------------------------------------ MAST_b-1_Smoe ------------------------------------------------------------ MAST_c-1_Smoe -------------T------------------V--------------------------- MAST2_Hsap ------------------------------------------------------------ MAST4_Hsap ------------------------------------------------------------ MAST1_Hsap ------------------------------------------------------------ MAST3_Hsap ------------------------------------------------------------ kin-4_Cele ------------------------------------------------------------ 9978_Tthe ----------------------------EIQVEG-------------------------- 15619_Tthe EGLKN---ENFIVQLKQNPGCD----LQNSI----------------------------- 19957_Tthe KGVKKENKKDIID--------SKDEELQQKLAEE-------------------------- MAST2_Spur ------------------------------------------------------------ MAST1_Mmus ------------------------------------------------------------ MAST2_Mmus ------------------------------------------------------------ MAST3_Mmus ------------------------------------------------------------ MAST4_Mmus ------------------------------------------------------------ DDB0185113_Ddis --------------------------T---MVGGH---VINTETPIPSNTAIPAKKEKKL DDB0216386_Ddis ------------------------------------------------------------ DDB0220700_Ddis ------------------------------SFTLY---N--------------------- DDB0220701_Ddis --------------------------SQTNILSPYPQRK--------------------- DDB0229452_Ddis ------------------------------------------------------------ CG6498_Dmel ------------------------------------------------------------ AqueK009_Aque ------------------------------------------------------------ MAST_c-2_Smoe ------------------------------AVEKH---D--------------------- MAST_b-2_Smoe --------------------------------------A--------------------- MAST_b-1_Smoe --------------------------------------A--------------------- MAST_c-1_Smoe ------------------------------AAEKH---D--------------------- MAST2_Hsap ------------------------------------------------------------ MAST4_Hsap ------------------------------------------------------------ MAST1_Hsap ------------------------------------------------------------ MAST3_Hsap ------------------------------------------------------------ kin-4_Cele ------------------------------------------------------------ 9978_Tthe ------------------------------------------------------------ 15619_Tthe ------------------------------------------------------------ 19957_Tthe ------------------------------------------------------------ MAST2_Spur ------------------------------------------------------------ MAST1_Mmus ------------------------------------------------------------ MAST2_Mmus ------------------------------------------------------------ MAST3_Mmus ------------------------------------------------------------ MAST4_Mmus ------------------------------------------------------------ DDB0185113_Ddis LSLAQSKSLFSASSSPSIPSLNLLNSDKPISPMMMGVKGFIPPPPINQQPISNIPTTTTT DDB0216386_Ddis ------------------------------------------------------------ DDB0220700_Ddis ------------------------------------------------------------ DDB0220701_Ddis ------------------------------------------------------------ DDB0229452_Ddis ------------------------------------------------------------ CG6498_Dmel ------------------------------------------------------------ AqueK009_Aque ------------------------------------------------------------ MAST_c-2_Smoe ------------------------------------------------------------ MAST_b-2_Smoe ------------------------------------------------------------ MAST_b-1_Smoe ------------------------------------------------------------ MAST_c-1_Smoe ------------------------------------------------------------ MAST2_Hsap ---------KDARE---------------FLDKQVCGTPEYIAPEVILRQGY-GKPVDWW MAST4_Hsap ---------KDARE---------------FLDKQVCGTPEYIAPEVILRQGY-GKPVDWW MAST1_Hsap ---------KDARE---------------FLDKQVCGTPEYIAPEVILRQGY-GKPVDWW MAST3_Hsap ---------KDARE---------------FIDKQVCGTPEYIAPEVIFRQGY-GKPVDWW kin-4_Cele -------V-VETQQ---------------FQDKQLCGTPEYIAPEVILRRGY-GKPVDWW 9978_Tthe -------M-INNEK---------------EQQKRIVGTPDYIAPEIITGESTNNKSLDWW 15619_Tthe ---------RPGGI---------------MKKNRVVGTPDYIPPEVINGESTNNQSIDWW 19957_Tthe -------Q-LQNIV---------------QQKKRIIGTPDYIAPEIINGESSSNPSLDWW MAST2_Spur ---------RDTKQ---------------FQDQQVCGTPQYIAPEVILRQGY-GKPVDWW MAST1_Mmus ---------KDARE---------------FLDKQVCGTPEYIAPEVILRQGY-GKPVDWW MAST2_Mmus ---------KDARE---------------FLDKQVCGTPEYIAPEVILRQGY-GKPVDWW MAST3_Mmus ---------KDARE---------------FVDKQVCGTPEYIAPEVIFRQGY-GKPVDWW MAST4_Mmus ---------KDARE---------------FLDKQVCGTPEYIAPEVILRQGY-GKPVDWW DDB0185113_Ddis TTTTTTGQQSQQQSQQQQQTTPPLPPHNIHRKLSCVGTPDYLAPEILLGIGH-GASADWF DDB0216386_Ddis --------IKNG-N---------------KKNNKCLGTPYYMSPEVINKRGY-GKTIDWW DDB0220700_Ddis --------TNNNNT---------------TENQKILGTPYYIPPEVILGKGY-GKTIDWW DDB0220701_Ddis ------NTLKTPLK---------------KPVKKVVGTPDYLSPEILLGTGH-GQTVDWW DDB0229452_Ddis --------FNQKKP---------------TSNDGILGSPRYISPEVLLFEPQ-SPAVDYW CG6498_Dmel ---------SETRQ---------------FSDKQVYGTPEYIAPEVILRQGY-GKPVDWW AqueK009_Aque ---------KD-YQ---------------FVDQEVYGTPDYIAPEVILGMPY-GFPVDWW MAST_c-2_Smoe ------SSDSSTKK---------------GRQQKTVGTPDYLAPEILLGTAH-GYPADWW MAST_b-2_Smoe ------MNDD-REH---------------NQLKSAVGTPDYLAPEILLGTEH-DHAADWW MAST_b-1_Smoe ------MNDD-REH---------------NQLKSAVGTPDYLAPEILLGTEH-DHAADWW MAST_c-1_Smoe ------SSDSSTKK---------------GRQQKTVGTPDYLAPEILLGTAH-GYPADWW *:* *:.**:: . . *:: MAST2_Hsap AMGIILYEFLVGCVPFFGDTPEE---------------LFGQVISDE--IVWPEG----- MAST4_Hsap AMGIILYEFLVGCVPFFGDTPEE---------------LFGQVISDE--INWPEK----- MAST1_Hsap AMGIILYEFLVGCVPFFGDTPEE---------------LFGQVISDD--ILWPEG----- MAST3_Hsap AMGVVLYEFLVGCVPFFGDTPEE---------------LFGQVVSDE--IMWPEG----- kin-4_Cele ALGIILYEFLVGIVPFFGETPEA---------------LFSKVISED--VEYPEE----- 9978_Tthe SMGVIMYEFLVGLPPFNADSVEE---------------IFDNIKNLR--MEWPEIGDIND 15619_Tthe SLGVMVYEFIAGIPPFNDESVEK---------------IFSNIKKGH--IEWPDVG---Y 19957_Tthe SVGVIMYELLVGIPPFNDSTREK---------------VFENIVNRR--IEFPPTGDPNE MAST2_Spur SMGVVLYEILVGCPPFFGETPEE---------------LFAQTINVM--IEWPDG----- MAST1_Mmus AMGIILYEFLVGCVPFFGDTPEE---------------LFGQVISDD--ILWPEG----- MAST2_Mmus AMGIILYEFLVGCVPFFGDTPEE---------------LFGQVISDE--IVWPEG----- MAST3_Mmus AMGVILYEFLVGCVPFFGDTPEE---------------LFGQVVSDE--IMWPEG----- MAST4_Mmus AMGIILYEFLVGCVPFFGDTPEE---------------LFGQVISDE--INWPEK----- DDB0185113_Ddis SLGVILYEFLCGVSPFNGSSVQE---------------TFQNILQR--NISWPE------ DDB0216386_Ddis ALGIIIFELLSGETPFVGDNQNM---------------IFEKITNYTNEINFPS------ DDB0220700_Ddis SLGIILYEFLIGYPPFQEDEPNESINPKSDNDEKNVRIIFNKITNHKKKLYFPK------ DDB0220701_Ddis ALGIILYEFLTGSPPFNDDTPEL---------------IFQHILHRDREMEWPE------ DDB0229452_Ddis SLGIVMFELITGTTPFIGETPEE---------------IFESILSRN--TECI------- CG6498_Dmel SMGIILYEFLIGCVPFFGETTEE---------------LFAHTVNDD--IEWPDS----- AqueK009_Aque SMGVILYEMMMGVTPFVSSTIQD---------------LFEEITNENLHISFPEE----- MAST_c-2_Smoe SVGVILFEFLTGIPPFNAEDPQM---------------IFENILNR--NIPWPNI----- MAST_b-2_Smoe SVGIILYEFLTGVPPFNAEHPQI---------------IFDNILNK--KISWPRV----- MAST_b-1_Smoe SVGIILYEFLTGVPPFNAEHPQI---------------IFDNILNK--KISWPRV----- MAST_c-1_Smoe SVGVILFEFLTGIPPFNAEDPQM---------------IFENILNR--NIPWPNI----- ::*::::*:: * ** . : * MAST2_Hsap -DE-ALPPDAQDLTSKLLHQNPLERLGT---GSAYEVKQHPFF MAST4_Hsap -D----------------------------------------E MAST1_Hsap -DE-ALPTEAQLLISSLLQTNPLVRLGA---GGAFEVKQHSFF MAST3_Hsap -DE-ALPADAQDLITRLLRQSPLDRLGT---GGTHEVKQHPFF kin-4_Cele -DE-ALPPEAADLCRRLLEKNPAERLGTL--NGAAQLMAHEFF 9978_Tthe G-D-KISPEAYDLIKRLLNPNYKERLGA---KGVKEIKEHAFF 15619_Tthe GED-EMTPEAQDLIKKLLNHDYKKRLGA---NGSQEIKQHKFF 19957_Tthe DEN-CISEEAQDLMEKLLTLDHKQRLGA---RGADEIKKHPFF MAST2_Spur -DD-ALSDEAMELINGFLQQDPLFRLGT---GGSEDVKGHRFF MAST1_Mmus -DE-ALPTDAQLLISSLLQTNPLVRLGA---GGAFEVKQHSFF MAST2_Mmus -DD-ALPPDAQDLTSKLLHQNPLERLGT---SSAYEVKQHPFF MAST3_Mmus -DE-ALPLDAQDLITRLLRQSPMDRLGT---GGTHEVKQHPFF MAST4_Mmus -D----------------------------------------E DDB0185113_Ddis ----DMSPEARDLIDKLLALDPRQRLGF---NGAEEIKSHPFF DDB0216386_Ddis ----YFSEVAIDLIQKLLQVDPLKRLGA---NGADEVKRHPFF DDB0220700_Ddis ----KLYPVAIDLIEKLLDPNPSVRLGA---NGVDEVKCHPFF DDB0220701_Ddis ----EISSEAKDLILKLLNPDPYKRLGA---NGAYEVKTHPFF DDB0229452_Ddis ----EIQKDAKDLIIKLLDPNPSTRIGS------KDIKNHPYF CG6498_Dmel -EDWPVQAEAKDIISQLLQQNPRDRLGTQ--SGALEMKEHEYF AqueK009_Aque -D--EIPDDAQDLVRQLMCFDPMYRLGSTAREGVSGVKSHPFF MAST_c-2_Smoe -PG-DMSFEAADFIDKLLAEDPNHRLGA---KGAAEVKAHPFF MAST_b-2_Smoe -PE-DVSYDACDLINRLLTDDPKRRLGY---RGAGEVKAHPFF MAST_b-1_Smoe -PE-DVSYDAYDLINRLLTDDPKRRLGY---RGAGEVKAHPFF MAST_c-1_Smoe -PG-DMSFEAADFIDKLLAEDPNHRLGA---KGAAEVKAHPFF