CLUSTAL W (1.83) multiple sequence alignment sek-1_Cele LVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRRSDCCPQM lic_Dmel LEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDCPYT MAP2K3_Mmus LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNTQEQKRLLMDLDINMRTVDCFYT MAP2K6_Mmus LEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFT MAP2K6_Hsap LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT MAP2K3_Hsap LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYT MEK3_Spur MIVIENLGRGAYGIVDKTRHEPTESIMAVKKMRAQVNSTEDKRILMDMDVAMRSSDCVYT : : :**:*.**:*:* :* : ::***:: :* .::::: ::* *: * sek-1_Cele VRFYGAMFREGDVWICMEVMDTSLDKFYRHAYK-IGKHIPEPFIGKMALSVIEGLNFMKE lic_Dmel VHFYGAMYREGDVWICMEVMSTSLDKFYPKVFL-HDLRMEESVLGKIAMSVVSALHYLHA MAP2K3_Mmus VTFYGALFREGDVWICMELMDTSLDKFYRKVLE-KNMKIPEDILGEIAVSIVRALEHLHS MAP2K6_Mmus VTFYGALFREGDVWICMELMDTSLDKFYKQVID-KGQTIPEDILGKIAVSIVKALEHLHS MAP2K6_Hsap VTFYGALFREGDVWICMELMDTSLDKFYKQVID-KGQTIPEDILGKIAVSIVKALEHLHS MAP2K3_Hsap VTFYGALFREGDVWICMELMDTSLDKFYRKVLD-KNMTIPEDILGEIAVSIVRALEHLHS MEK3_Spur VEFYGALFQEGDVWICMEVMDTCLDKLYKNKLKPQKIFVPENILSRISFSIVSALKYLQT * ****:::*********:*.*.***:* : : * .:..::.*:: .*..:: sek-1_Cele QLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPYMPPERIDGET-K lic_Dmel QLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDAGCKPYMAPERIDPQGNP MAP2K3_Mmus KLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQ MAP2K6_Mmus KLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQ MAP2K6_Hsap KLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQ MAP2K3_Hsap KLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQ MEK3_Spur RLKVIHRDVKPSNVLANHNGKIKLCDFGISGQLVNSMAKTQDAGSRQYMAPERIDPDMSA :*.:*********:* * *::*:******* *.:*:*** :**.: **.****: : sek-1_Cele SAYDVRADVWSLGITIIEIAVGTHPYANWKTPFEQLKQVVKEPPPKLPMESGFSVDCQYF lic_Dmel AQYDIRSDVWSLGIGMIEMATGRYPYDNWRTPFEQLRQVVEDSPPRLPEG-TFSPEFEDF MAP2K3_Mmus KGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPAD-QFSPEFVDF MAP2K6_Mmus KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-KFSADFVDF MAP2K6_Hsap KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-KFSAEFVDF MAP2K3_Hsap KGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPAD-RFSPEFVDF MEK3_Spur KGYDVKSDVWSFGITMIEIATNAYPYERWHDMFQQLTQVVKGTSPALPKE-KFSEDIQDF *.:::*:**:** :**:* .** * *:** ***: ..* ** ** : * sek-1_Cele VKRCLEKDYNERPKYPELLAMPFM lic_Dmel IAVCLQKEYMARPNYEQLLKHSFI MAP2K3_Mmus TSQCLRKNPAERMSYLELMEHPFF MAP2K6_Mmus TSQCLKKNSKERPTYPELMQHPFF MAP2K6_Hsap TSQCLKKNSKERPTYPELMQHPFF MAP2K3_Hsap TAQCLRKNPAERMSYLELMEHPFF MEK3_Spur INKCLKKNCTERPSYTRLLEHEFI **.*: * .* .*: *: