CLUSTAL W (1.83) multiple sequence alignment mkk-4_Cele LQDLGAIGNGNFGTVYKMRHKETGKLIAVKRIRCNN--IG---HREQIRLLREHDTIVKS VZC374L.1_Cele LRHLSQVGAGYYGTVHKMQHNESGRLIAVKKIRYN----N---ICDQTRLLKEHDTHMKS ZC449.6_Cele LQELELLGNGSFGVVRKMLHRPSNVEMAVKQISLINNGPDDAFNKSMQRFRLEVEATKAA Mkk4_Dmel LEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRST---VD---EKEQKQLLMDLEVVMKS MAP2K4_Mmus LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRST---VD---EKEQKQLLMDLDVVMRS MAP2K4_Hsap LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRST---VD---EKEQKQLLMDLDVVMRS MKK4_Spur LEDMGEIGRGAFGSVNKMWHKQSQSIMAVKRIRST---VD---EKDQKQLLMDLDVVKRS AqueK244_Aque ---VSEIGRGQFGQVNKMTHMVTGKVMAVKRIRVT---PD---QAKSKSLLMEWKVPKNS AqueK245_Aque LDVEEELGRGQYGQVNRMKHKPTGKIMAVKRIRAT---PD---QAENKRLLMDYNVAMRS AqueK246_Aque LQDIGSIGEGHFGVVSKMNHTTAKHIMAVKKIPMK----D---LRTSGGNVLELDVIKKV :* * :* * :* . :***:* . : .. mkk-4_Cele EKGPNIVKFYGAIFSEGDCWICMELMDISMDLLYKRVYMVKNSRLNENVVGHITVCTVDA VZC374L.1_Cele ENVPNIVKFFGACFSEGDCWICMELMDISIDFLYKRVYSVKKSRLNENIIGHITVCIVDA ZC449.6_Cele SNCDEIVRYYGITFNEGVAWMCMELMDLSLDKLYMIAHDIQKVEIPEQILGAVAVATIRA Mkk4_Dmel NECIYIVQFYGALFKEGDCWICMELMDTSLDKFYKYIYEKQQRHIPESILAKITVATVNA MAP2K4_Mmus SDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKA MAP2K4_Hsap SDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKA MKK4_Spur ANCVYIIKFFGALFKEGDCWICMELMDSSLDKFYRFVHEVQNTYIPENIMGKVAYATVKA AqueK244_Aque VECPYTILFYGAFFCENDVWICMELMDRSLEELYHLVYDKLKESIPEL--------TLKA AqueK245_Aque IDCPFTITFYGALFREGDVWICMELMDKSLDKLYQLVYKKLNEKIPEVIVGKMADSTLKA AqueK246_Aque KECPFIVHFYGCLLREGHVWICMELLDSSMAQVSEIVYNKMNERIPEDILGKMTVAVINA . : ::* : *. *:****:. *: . : . : * : * mkk-4_Cele LDYLKKELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEESFAKTHDAGCQPYLAPERI VZC374L.1_Cele LDYLKRKLNRIHRDVKPSNILINAAGDVKLCDFGICGDLVGSYAITVEAGCVQYLAPERI ZC449.6_Cele LEHLKTTHHIIHRDIKPSNILLDRHGCVKLCDFGICGYLQNSVAQSVDVGCRPYMAPERL Mkk4_Dmel LNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERI MAP2K4_Mmus LNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERI MAP2K4_Hsap LNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERI MKK4_Spur LNYLKETLKIIHRDVKPSNILLDRGGNIKLCDFGISGQLVDSIARTMDAGCKPYMAPERI AqueK244_Aque LTYLHDKLNVMHRDVKPSNILINQNGEIKLCDFGIAGELVDSLAKT-DIGCRPYLAPERI AqueK245_Aque LTYLHDELQVMHRDVKPSNILINKKGEIKLCDFGIAGELVNSLAKT-DIGCRPYLAPERI AqueK246_Aque LHFLQKELKIIHRDVKPSNILVSKVGEFKLCDFGISGKLVDSIARTMDVGCRPYMAPERI * .*: : :***:******: * .*******.* * * * : : ** *:****: mkk-4_Cele TS---SDKYDVRSDVWSLGITLYEIATGKFPYQ--EWN--SLFDQIATVVSGDPPILHPD VZC374L.1_Cele EN---MDKYDIRSDVWSLGITLYEIATGVYPYR--GWS--NQMEHIEIVVNGDSPILLQN ZC449.6_Cele APN--GDGYDIKSEVWSLGITMVEVANGKYPYD--GFMDAPILDQVRMVVYGDPPILDSD Mkk4_Dmel DPER-AKGYDVRSDVWSLGITLMEVATGNFPYR--KWD--SVFEQLCQVVQGEPPRLLTS MAP2K4_Mmus DPSASRQGYDVRSDVWSLGITLYELATGRFPYP--KWN--SVFDQLTQVVKGDPPQLSNS MAP2K4_Hsap DPSASRQGYDVRSDVWSLGITLYELATGRFPYP--KWN--SVFDQLTQVVKGDPPQLSNS MKK4_Spur DPFQSRPGYDIRSDVWSLGITMYEVATGEFPYP--KWN--SVFEQLSQVVKGDPPRLKHN AqueK244_Aque DEP--QHEYDHRSDVWSLGITMYEIAMGEFPYPVDTLR--SIFGLIEMIVKGSPPRLTSD AqueK245_Aque YGG--QHKYDHRSDVWSLGITLCELATGEFPYP--PYR--NLFEQIKLVVEGAPPQLPDD AqueK246_Aque DPARACLGYTIQSDVWSYGITLVELAQGSFPYK--KWN--TIFDQLNAVVSGDPPSLPPE * :*:*** ***: *:* * :** : : :* * .* * . mkk-4_Cele SDDFHYSLPLVKFINTCLTKDRRHRPKYDTLKSFDFY VZC374L.1_Cele MHNLHYTDPLCRFINTCLRKNKDDRPKYVNLKTFSFY ZC449.6_Cele ---HEVSMSMKRFIALCTIKDRNLRASFDDLKK---T Mkk4_Dmel YNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFI MAP2K4_Mmus -EEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI MAP2K4_Hsap -EEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI MKK4_Spur -DFYSYSEDFISFVNKCLTKDEKYRPKYKNLLEYKFI AqueK244_Aque ----RFSGEHKDFVAQCLTKSRDSRPRYKDLNAHSFI AqueK245_Aque ---GTFSEDFRDFVSKCLTKERDERPRYEVLNGHKFI AqueK246_Aque ----NFTRELREFTAACLVKDSDQRPNYVQLQEKEFF : * * *. *. : *