CLUSTAL W (1.83) multiple sequence alignment RSK4_Hsap FELLKV--LGQGSFGKVFLVRKKTGPDAGQLYAMKVLKK--ASLKVRD---RVRTKMERD RSK4~b_Hsap YELKED--IGVGSYSV---CKRCIHATTNMEFAVKIIDK--SKR---------DPSEEIE RSK3_Hsap FELLKV--LGQGSYGKVFLVRKVKGSDAGQLYAMKVLKK--ATLKVRD---RVRSKMERD RSK3~b_Hsap YEIKED--IGVGSYSV---CKRCVHKATDTEYAVKIIDK--SKR---------DPSEEIE RSK2_Hsap FELLKV--LGQGSFGKVFLVKKISGSDARQLYAMKVLKK--ATLKVRD---RVRTKMERD RSK2~b_Hsap YEVKED--IGVGSYSV---CKRCIHKATNMEFAVKIIDK--SKR---------DPTEEIE RSK1_Hsap FELLKV--LGQGSFGKVFLVRKVTRPDSGHLYAMKVLKK--ATLKVRD---RVRTKMERD RSK1~b_Hsap YVVKET--IGVGSYSE---CKRCVHKATNMEYAVKVIDK--SKR---------DPSEEIE S6k_Dmel YNLLQE--LGRGTFSV---CRLCEHRASKKHYAVKVIEK--AAVAAASTSTSADCWEEVE S6k~b_Dmel FELLRV--LGEGSFGKVFLVRKIIGKDAGTLYAMKVLKK--ATLKVKD---RVRSTNERK RSK1_Mmus FELLKV--LGQGSFGKVFLVRKVTRPDSGHLYAMKVLKK--ATLKVRD---RVRTKMERD RSK1~b_Mmus YVVKET--IGVGSYSV---CKRCVHKATNMEYAVKVIDK--SKR---------DPSEEIE RSK2_Mmus FELLKV--LGQGSFGKVFLVKKISGSDARQLYAMKVLKK--ATLKVRD---RVRTKMERD RSK2~b_Mmus YEVKED--IGVGSYSV---CKRCIHKATNMEFAVKIIDK--SKR---------DPTEEIE RSK3_Mmus FELLKV--LGQGSYGKVFLVRKVTGSDAGQLYAMKVLKK--ATLKVRD---RVRSKMERD RSK3~b_Mmus YEIKED--IGVGSYSV---CKRCVHKATDAEYAVKIIDK--SKR---------DPSEEIE RSK4_Mmus FDLLKV--LGQGSFGKVFLVRKKTGPDAGQLYAMKVLRK--ASLKVRD---RVRTKMERD RSK4~b_Mmus YELKED--IGIGSYSV---CKRCIHSASNVEFAVKIIDK--NKR---------DPSEEIE T01H8.1a_Cele FELLKV--LGQGSFGKVFLVRKVRGRDSGHVYAMKVLKK--ATLKVRD---RQRTKLERN T01H8.1a~b_Cele YEILEK--IGNGAHSV---VHKCQMKATRRKYAVKIVKK--AVF---------DATEEVD RSK1_Spur YDLQED--IGLGSYSV---CKRCTHKATGQDYAVKIIKK--NTK---------DVREEIE RSK2_Spur ------------------------------------------------------------ AqueK025_Aque FELVKV--LGQGSFGKVFLVRRLVGHDAGKLYAMKVLKK--ATLKVRD---RIRTKMERD AqueK025~b_Aque YDIKEDMLLGYGSYSR---CVRCIHRATNQEFAVKIISKEKSTR---------DVDEEIE RSK4_Hsap ILV-E-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSK-EVLFTEEDVKFYLAEL RSK4~b_Hsap ILMRY-GQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILK-QKCFSEREASDILYVI RSK3_Hsap ILA-E-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAEL RSK3~b_Hsap ILLRY-GQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILR-QRYFSEREASDVLCTI RSK2_Hsap ILV-E-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAEL RSK2~b_Hsap ILLRY-GQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILR-QKFFSEREASAVLFTI RSK1_Hsap ILA-D-VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAEL RSK1~b_Hsap ILLRY-GQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILR-QKFFSEREASFVLHTI S6k_Dmel IMLRY-GNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILA-VGQMCESEASAVLRTI S6k~b_Dmel ILA-D-VGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAEL RSK1_Mmus ILA-D-VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAEL RSK1~b_Mmus ILLRY-GQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILR-QKFFSEREASFVLHTI RSK2_Mmus ILV-E-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAEL RSK2~b_Mmus ILLRY-GQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILR-QKFFSEREASAVLFTI RSK3_Mmus ILA-E-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAEL RSK3~b_Mmus ILLRY-GQHPNIITLKDVYDDGKYVYLVMELMRGGELLDRILR-QRCFSEREASDVLYTI RSK4_Mmus ILV-E-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSK-EVLFTEEDVKFYLAEL RSK4~b_Mmus ILMRY-GQHPNIISLKEVFDDGKYVYLVTDLMKGGELLDRILK-KKCFSEQEASNVLYVI T01H8.1a_Cele ILA-H-ISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEDDVKFYLAEL T01H8.1a~b_Cele ILLRH-SHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANL RSK1_Spur ILLRY-GHHSNVITLRDVFDDGQNVYMVMELMRGGELLDRLLK-QKFLSEREACEIMLTV RSK2_Spur ------------------------------------------------------------ AqueK025_Aque ILA-D-VRHPFVVALEYAFQTEGKLYLVLEFLRGGDLFTRLSK-EVMFTEEDVKFYLAEL AqueK025~b_Aque ILLRYAPQHENIIKLRDVYDDGTYIYMVMELMRGGELLDKIIS-QKFFSEKEAAAVLAIL RSK4_Hsap ALALDHLHQLGIVYRDLKPENILL-DEIG---HIKLTDFGLSKESVDQEKKAYSFCGTVE RSK4~b_Hsap SKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTAN RSK3_Hsap ALALDHLHSLGIIYRDLKPENILL-DEEG---HIKITDFGLSKEAIDHDKRAYSFCGTIE RSK3~b_Hsap TKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTAN RSK2_Hsap ALALDHLHSLGIIYRDLKPENILL-DEEG---HIKLTDFGLSKESIDHEKKAYSFCGTVE RSK2~b_Hsap TKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTAN RSK1_Hsap ALGLDHLHSLGIIYRDLKPENILL-DEEG---HIKLTDFGLSKEAIDHEKKAYSFCGTVE RSK1~b_Hsap GKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTAN S6k_Dmel ASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTAN S6k~b_Dmel ALAMNHLHTLGIIYRDLKPENILL-DEHG---HIALTDFGLSKQPLDG-SKTYSFCGTVE RSK1_Mmus ALGLDHLHSLGIIYRDLKPENILL-DEEG---HIKLTDFGLSKEAIDHEKKAYSFCGTVE RSK1~b_Mmus SKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTAN RSK2_Mmus ALALDHLHSLGIIYRDLKPENILL-DEEG---HIKLTDFGLSKESIDHEKKAYSFCGTVE RSK2~b_Mmus TKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTAN RSK3_Mmus ALALDHLHGLGIIYRDLKPENILL-DEEG---HIKITDFGLSKEATDHDKRAYSFCGTIE RSK3~b_Mmus ARTMDYLHSQGVVHRDLKPSNILYMDESGNPESIRICDFGFAKQLRAENGLLMTPCYTAN RSK4_Mmus ALALDHLHRLGIVYRDLKPENILL-DEIG---HIKLTDFGLSKESVDQEKKAYSFCGTVE RSK4~b_Mmus TKTVECLHSQGVVHRDLKPSNILYMDESAHPDSIKICDFGFAKQLRGENGLLLTPCYTAN T01H8.1a_Cele TLALEHLHSLGIVYRDLKPENILL-DADG---HIKVTDFGLSKEAIDSEKKTYSFCGTVE T01H8.1a~b_Cele LNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQ RSK1_Spur TRTMDFLHQQKVVHRDLKPSNILYADETYSPGTLRIADFGFAKQMRADNGMLMTPCYTAN RSK2_Spur ------------------------------------------------------------ AqueK025_Aque ALALHHLHGLGIVYRDLKPENILL-DADG---HIKLTDFGLSKESVD-DKKTFSFCGTVE AqueK025~b_Aque TDTVSYLHLKGVVHRDLKPSNILYADPSCSPRSLRIADFGFAKQLRAENGLLMTPCYTAN RSK4_Hsap YMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMIL----KAKL-G-- RSK4~b_Hsap FVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPN-DTPEEILLRIGNGKF-SLS RSK3_Hsap YMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL----KAKL-G-- RSK3~b_Hsap FVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPD-DTPEEILARIGSGKY-ALS RSK2_Hsap YMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMIL----KAKL-G-- RSK2~b_Hsap FVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPD-DTPEEILARIGSGKF-SLS RSK1_Hsap YMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLIL----KAKL-G-- RSK1~b_Hsap FVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPS-DTPEEILTRIGSGKF-TLS S6k_Dmel FVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPN-DSPDVILKRIGSGQI-DFT S6k~b_Dmel YMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQIL----RSKL-G-- RSK1_Mmus YMAPEVVNRQGHTHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLIL----KAKL-G-- RSK1~b_Mmus FVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPS-DTPEEILTRIGSGKF-TLS RSK2_Mmus YMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMIL----KAKL-G-- RSK2~b_Mmus FVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPD-DTPEEILARIGSGKF-SLS RSK3_Mmus YMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL----KAKL-G-- RSK3~b_Mmus FVAPEVLKRQGYDAACDVWSLGILLYTMLAGFTPFANGPD-DTPEEILARIGSGKY-ALS RSK4_Mmus YMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMIL----KAKL-G-- RSK4~b_Mmus FVAPEVLTQQGYDAACDIWSLGVLLYTMLAGYTPFSNGPN-DTPEEILLRIGNGRF-SLS T01H8.1a_Cele YMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQIL----KAKL-S-- T01H8.1a~b_Cele FVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMGPN-DTPDQILQRVGDGKI-SMT RSK1_Spur FVAPEVLKKQGYDAACDIWSLGVILYTMLAGFTPFVHKPD-DSSKVILARIQEGKYLTMN RSK2_Spur ------VNDRGHSQISNYFSLSTVQYEMLTGALPFQGQHRKETMALIL----KAKL-G-- AqueK025_Aque YMAPEVVNRKGHDITADWWSFGVLMYEMLTGSLPFQGENRKATMNMIL----KAKL-G-- AqueK025~b_Aque YVAPEVLKKQGYDAAIDIWSLGVLLYTMLAGECPFAAGPD-DGPDKILSRISEGKI-NLT : :*: : :* . : . **:* ** ** .: RSK4_Hsap --MPQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF RSK4~b_Hsap GGNWDNISDGAKDLLSHMLHMDPHQRYTA-----EQILKHSWI RSK3_Hsap --MPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF RSK3~b_Hsap GGNWDSISDAAKDVVSKMLHVDPHQRLTA-----MQVLKHPWV RSK2_Hsap --MPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF RSK2~b_Hsap GGYWNSVSDTAKDLVSKMLHVDPHQRLTA-----ALVLRHPWI RSK1_Hsap --MPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFY RSK1~b_Hsap GGNWNTVSETAKDLVSKMLHVDPHQRLTA-----KQVLQHPWV S6k_Dmel SSRWALISVPAKELLRQMLHIVPENRPTA-----ARILEHDWL S6k~b_Dmel --MPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFF RSK1_Mmus --MPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFY RSK1~b_Mmus GGNWNTVSETAKDLVSKMLHVDPHQRLTA-----KQVLQHPWI RSK2_Mmus --MPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF RSK2~b_Mmus GGYWNSVSDTAKDLVSKMLHVDPHQRLTA-----ALVLRHPWI RSK3_Mmus --MPQFLSAEAQSLLRALFKRNPCNRLGAGVDGVEEIKRHPFF RSK3~b_Mmus GGNWDSISDAAKDVVSKMLHVDPQQRLTA-----VQVLKHPWI RSK4_Mmus --MPQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEVKRHAFF RSK4~b_Mmus GGIWDNISRGAKDLLSHMLHMDPHQRYTA-----EQVLKHPWI T01H8.1a_Cele --MPHFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFF T01H8.1a~b_Cele HPVWDTISDEAKDLVRKMLDVDPNRRVTA-----KQALQHKWI RSK1_Spur GGNWDNISDRAKDLISRMLHVDPFQRPST-----KQVLQHTWF RSK2_Spur --MPQFLSAEAQSLLRMLFKRNPQNRLGAGPNGINDIKSHAFF AqueK025_Aque --MPQFLSPEAQSLLRVLFKRNPLNRLCYGTNGIDNIKAHPFF AqueK025~b_Aque GGNWDTVSAAAKDLVLRMLHVDPQQRCTA-----AQILQHPWI :: *:.:: ::. . .* * :