CLUSTAL W (1.83) multiple sequence alignment BCK1_Scer WMKGEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQ-------------------- SSK2_Scer WQKRNFIGGGTFGRVYSAVDLDNGEILAVKEINIQDSK---------------------- SSK22_Scer WQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTT---------------------- STE11_Scer WLKGACIGSGSFGSVYLGMNAHTGELMAVKQVEIKNNNIGVPTDNNKQANSDENNEQEEQ 6622_Tthe AQVGELIGQGAYGRVYKGFVKSTGKFIAIKEMKEEMMLG--------------------- 7147_Tthe YKKCELIDKGAYGKVYKGIDTITNQVVAIKYIEITGT-F--------------------- 11359_Tthe FKKGHIIDRGSYGEVYQCLEVNTGQLYAIKTIRKNKD-K--------------------- 15684_Tthe ---DKILGKGTFGTVVLGHNKNTGEIVAVKLIETQYD-R--------------------- 18758_Tthe WKSGDFIGAGSFGQVFTAMNCNTGEIFVVKKIMVHGQ-S--------------------- 23105_Tthe VELRELLGEGAYGKVYKGFIKKTGKFIAVKQLKLGLKDN--------------------- 29763_Tthe WQSGEVLGTGSFGQVILGMNIDTGEFMAVKQVHIGGYNQ--------------------- MEKKalpha_Ddis WQKGQILGRGGYGSVYLGLNKDTGELFAVKQLEIVDINSD-------------------- CC1G_12014_Ccin WIKGALIGAGSFGKVYLGMDASNGLLMAVKQVELPQGDG--------------------- CC1G_10524_Ccin WIRGELLGKGSYGRVYLALNATTGEVMAVKQVELPKTPSD-------------------- CC1G_13687_Ccin WQQGRFIGAGAFGSVYLAMNLDSGSLMAVKEIKFQELS---------------------- CC1G_10513_Ccin WVRGELIGKGTYGRVYLALNATTGEMIAVKQVELPQTPSD-------------------- GK078_Glam YSLGRIIGHGSFGQVYLALEHLTGKLLAVKEMVVKNCS---------------------- :. * :* * .. . .:* : BCK1_Scer --------------N--EAILSTVEALRSEVSTLKDLDHLNIVQYLGFENKN--NIYSLF SSK2_Scer ------------------SMQKIFPLIKEEMSVLEILNHPNIVSYYGVEVHR--DKVNIF SSK22_Scer ------------------TMKKIFPLIKEEMTVLEMLNHPNIVQYYGVEVHR--DKVNIF STE11_Scer QEKIEDVGAVSHPKTNQNIHRKMVDALQHEMNLLKELHHENIVTYYGASQEG--GNLNIF 6622_Tthe -----------------EDAHSLLESICKEIQLLKQLSHKNIVNYIGSKKQE--GSVYIY 7147_Tthe -----------------EEVKKEINSLKKEIVLLKKLNHQNIVKYYDFEISDDKSGVDII 11359_Tthe -----------------AVLEKEVQSLAKEIKEYKKLSHKNIVKYIDTELDEDEKGINII 15684_Tthe --------------------KQKYKSIIDEVKILKQMRHKNIVRYYGIQEHKAKDHIGIV 18758_Tthe -----------------KLDKEFLDEQEKELRIMQTLSHKHIIQYKGHERQQ--DCLCIF 23105_Tthe -----------------NKLQEKLEQYLQEIALLNHLEHPNIVKYYDCKHEE--DNILIY 29763_Tthe -----------------KDRQEKIQQIQSEIEALRNFSDKNIVRYIGIKKSE--TSINIF MEKKalpha_Ddis -----------------PKLKNMILSFSKEIEVMRSLRHDNIVRYLGTSLDQ--SFLSVF CC1G_12014_Ccin --------------PSQERKKSMLSALEREIELLKVLQHENIVQYLYSSSDD--EYLNIF CC1G_10524_Ccin --------------KMKPQQLDVMKALKFEGDTLKDLDHPNIVSYLGFEESQ--DYLSIF CC1G_13687_Ccin ------------------GLPNLYAQIKDELSVMEMLHHPNVVEYYGIEVHR--DKVYIF CC1G_10513_Ccin --------------RNDSRQNTVVQALKLESETLKDLDHPHIVQYLGFEETP--ANLSIF GK078_Glam --------------------REVLEAIDAETRILINLRHPNIVNIYDIEVSDDGNKLLIV * : . ::: . : BCK1_Scer LEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHSKGILHRDMK---------AD SSK2_Scer MEYCEGGSLAALLEHGRIEDEMVTQVYTLQLLEGLAYLHESGIVHRDVK---------PE SSK22_Scer MEYCEGGSLASLLDHGRIEDEMVTQVYTFELLEGLAYLHQSGVVHRDIK---------PE STE11_Scer LEYVPGGSVSSMLNNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIK---------GA 6622_Tthe MEYMPGGSISEMLKKYGGFDEEVIQKFVKQLLEGLIYLHSKGVIHRDLK---------GA 7147_Tthe LEYVPNGSLRMALNKQRCFDETKAAIYTKQVLEGLDYLHKNNIIHRDLK---------GA 11359_Tthe LEYVSGGSIRQMLDKFGKFNEKVISIYTNQVLQGLKYLHSNHVFHRDIK---------GG 15684_Tthe CEYVSGGSLWRLIQKFGKFSEPLIRKYTTDILYGLQYLHYHGITHRDIK---------GA 18758_Tthe LEYMSEGNIDQMLKKFGPLEEQTIKVYARQILSGIQYLHSQKVIHKDIK---------GA 23105_Tthe MEQMPGGSLSSMLEKFGRFEEALIKKFVKQIISGLAYLHSQGIVHRDIKLTYINKILQGA 29763_Tthe LEYVPGGSISSLLYRYGKFNETLIRKFTQQILKGLEYLHAHEIIHRDIK---------GA MEKKalpha_Ddis LEYIPGGSISSLLGKFGAFSENVIKVYTKQILQGLSFLHANSIIHRDIK---------GA CC1G_12014_Ccin LEYVPGGSVATLLSNYGAFEEPLVRNFVRQILQGLSYLHERDIIHRDIK---------GA CC1G_10524_Ccin LEYVPGGTVGSLLVKNGRLREEVTKSWLRQILQGLDYLHGKGILHRDLK---------AD CC1G_13687_Ccin EEYCQGGSLAALLEHGRIEDERILQLYTVQMLDGLSYLHSQGIVHRDIK---------PD CC1G_10513_Ccin LEYVPGGSIGSCLHKHGKFSENVTKSFTGQILSGLEYLHSKGILHRDLK---------AD GK078_Glam MDFIAGGSLASLSKSFKGIPEILCRRYARQILEAIKHMHRQNVAHLDLK---------CS : *.: * ::: .: .:* : * *:* BCK1_Scer NLLLDQDGICKISDFGISRKSKDI--YS-------------------------------N SSK2_Scer NILLDFNGVIKYVDFGAAKKIANN--GTRLASMNKIENADGEHEDVTHVSDSKAVKNNEN SSK22_Scer NILLDFNGIIKYVDFGTARTVVGS--RTRTVRNAA----------------VQDFGVETK STE11_Scer NILIDIKGCVKITDFGISKKLSPL--NK-----------------------------KQN 6622_Tthe NILSDGQGNVKLADFGAARNIENI-LQH-S-------------------------LSQSE 7147_Tthe NLLLDAEGRAKLTDFGTAKQIEFD-LRK-SQVK--E-------------------EDIAK 11359_Tthe NILIDTDGTIKLTDFGTLKLHKKD-AYI-NHSK-SQ----------------SQLSHNQL 15684_Tthe NILVDSDGVCKLADFGLAKSISQE-IDE-------------------------------G 18758_Tthe NILVGSDGIVKLSDFGCAKQLELT-LNS-----------------------------NKE 23105_Tthe NILTDGNGTVKLADFGAARYRDTI-CLP-T-------------------------ADGSE 29763_Tthe NVLVDKDGNCKLADFGSAKKIVEE----------------------------------KG MEKKalpha_Ddis NILIDTKGIVKLSDFGCSKSFSG--IV--------------------------------S CC1G_12014_Ccin NILVDNKGGVKISDFGISKKVDDN-LLG----------------------------GNRL CC1G_10524_Ccin NILVDHSGVCKISDFGISKKAGEI--NR-----------------------------A-K CC1G_13687_Ccin NILLDQLGRIKFVDFGAAKILAKN--QHTLQRSRRST-------DAA----FNAANGIGV CC1G_10513_Ccin NILVEMTGICKISDFGISKRTDDL--HG-------------------------------G GK078_Glam NIMIGGDGLVKLVDFGTATRLARDDIINELQRRKETE-ADPKKPG------L-PSEAAKK *:: * * *** BCK1_Scer SDMTMR-GTVFWMAPEMVDT-K-QGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVV---AA SSK2_Scer ALLDMM-GTPMYMAPESITGSTTKGKLGADDVWSLGCVVLEMITGRRPWANLDNE---WA SSK22_Scer SLNEMM-GTPMYMAPETISGSAVKGKLGADDVWALGCVVLEMATGRRPWSNLDNE---WA STE11_Scer KRASLQ-GSVFWMSPEVVKQT---ATTAKADIWSTGCVVIEMFTGKHPFPDFSQM---QA 6622_Tthe FCNSIK-GSLYWMAPELIKNE---KHGRRIDVWSLGCTVIEMASAQHPWENIKKF---SD 7147_Tthe MNKSLK-GTPNWMAPEVIERT---GHTTSADIWSIGCIVIEMITGKPPYPGLSAK---EV 11359_Tthe DYGTIQSQKPFWTAPEVLKNED--SHDASSDIWSVGCLVIEMITALPPYYNLNDKSS-QE 15684_Tthe QLKLPQ-GTPNWMAPEVCRS----GTCRFSDIWSLGCTVYEMITGKPPFSNFLAE---TI 18758_Tthe MNKTLK-GSVPWMSPEIVTQT---KYDTKADIWSFGCTILEMAQAEAPWSNYQFDNPIAA 23105_Tthe FCNSIK-GSLYWMAPELLNQE---SHGRKSDIWSLGCTMIEMATGKHPWPDCRTF---PQ 29763_Tthe HNDSIR-GTPYWMAPETIKQL---GSG------SIGCTVIEMATAKPPWADKSPI---QA MEKKalpha_Ddis QFKSMQ-GTPYWMAPEVIKQTG-HG--RSSDIWSLGCVIVEMATAQPPWSNITEL---AA CC1G_12014_Ccin HRPSLQ-GSVFWMAPEVVKQT---GHTKKADIWSVGCLVVEMLTGEHPWAQLTQM---QA CC1G_10524_Ccin AHTGMK-GTSFWMAPEILSPGE-KGYDVKVDIWSVGCVAVEMWTGKRPWYGHEWW---PV CC1G_13687_Ccin MSNGLT-GTPMYMSPEMIKNDR-RGRHGATDIWSLGCVILQCATGRKPWSNLDNE---WA CC1G_10513_Ccin AFTAMQ-GTVFWMAPEVINTQK-KGYNFKIDIWSVGCVVLEMWGGRRPWTGQEMV---TV GK078_Glam FNLGIK-GSPYWIAPECVRSTL-YD-IFKADIWSIGCLFIEMFTTYPPFFQFKQV---PA . : :** : ** : *: BCK1_Scer -MFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEI----------------------NP SSK2_Scer IMYHVAA-GHTPQFPTKD--EVSSAGMKFLERCLIQ----------------------NP SSK22_Scer IMYHVAA-GRIPQLPNRD--EMTAAGRALLGKVFGS----------------------RP STE11_Scer -IFKIGTN-TTPEIPSW----ATSEGKNFLRKAFEL----------------------DY 6622_Tthe -LANAVIEQQPIPIPQH----LSEECKDFISKCCT----------------------YDK 7147_Tthe -FTKIASG-----------------------GCLQ----------------------TDP 11359_Tthe -ITKYIMDGNIPNFPEK----LSEQCLEFLQKTLK----------------------VNP 15684_Tthe -ILRVGLLKQPPQFLENL--QISEKLSDFLLHCFQ----------------------IKP 18758_Tthe -IMKIGLSDEIPQIPET----ISPDLNQFIRKCLQ----------------------RDP 23105_Tthe -LALIVKTNQCPPIPEH----LSDECKDFIRQCCT----------------------FDK 29763_Tthe -MFYIANAQQPPPIPEH----LSPVCKDFISKCLKYQNQIELVDLTKTQQILFLQFRINP MEKKalpha_Ddis VMYHIASSNSIPNIPS----HMSQEAFDFLNLCFKR----------------------DP CC1G_12014_Ccin -IFKIGSS-ARPTIPSD----ISAEAQDFLQKTFEI----------------------NH CC1G_10524_Ccin -LMKVAEDKSPPPIPEDI--PMGHLAQSFHNQCFRP----------------------DP CC1G_13687_Ccin IMFHIGVSTQHPPLPEPG--QLSPLGIDFIKQCLTI----------------------DP CC1G_10513_Ccin -MFKLYEAKLPPPVPDDV--VLSELGDDFRRKCFAIFMTDG--------------ACSNP GK078_Glam LLYHIATITEPPGLPE----TMSDEGRDFLSKCLQI----------------------NP : BCK1_Scer EKRPTANELLSHPFS SSK2_Scer SKRASAVELLMDPWI SSK22_Scer H------------YE STE11_Scer QYRPSALELLQHPWL 6622_Tthe KMRPKSQQLFNHPFL 7147_Tthe KKRLTTSQLLKTPFI 11359_Tthe KERATVNELIQLKFI 15684_Tthe EERWNVDQLLQHPFI 18758_Tthe SKRPTATELLNDSFL 23105_Tthe KERPTADVLLKHPFL 29763_Tthe NDRYNVRQLLNHPFI MEKKalpha_Ddis KERPDANQLLKHPFI CC1G_12014_Ccin ELRPHAAELLQHPWL CC1G_10524_Ccin ADRPHASVMLKHPYL CC1G_13687_Ccin TFRPSAKELMDHPWM CC1G_10513_Ccin DERPPAAELRLHPYL GK078_Glam EARASVDDLLAHPWV :