CLUSTAL W (1.83) multiple sequence alignment TGFbR1_Hsap IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA BMPR1B_Mmus IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA BMPR1A_Mmus IQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA ALK7_Mmus IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA ALK4_Mmus IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA ALK2_Mmus ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIA ALK1_Mmus VALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIA daf-1_Cele IRLTGRVGSGRFGNVSRGDYRGEAVAVKVFNALDEPAFHKETEIFETRMLRHPNVLRYIG BMPR1A_Hsap IQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA BMPR1B_Hsap IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA ALK7_Hsap IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA ALK4_Hsap IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA tkv_Dmel IQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFIA SAX_Dmel VTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIG BABO_Dmel VQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIA TGFBR1_Mmus IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA sma-6_Cele LTIIKTIGQGRYGEVRKALYRGSYVAVKTFYTTDEDSWKNERDVYQTNMINHENILQFVA ALK2_Hsap ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIA ALK1_Hsap VALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIA TGFbR1_Spur IVIQDCIGKGRYGEVYRGKWRGESVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA ALK2_Spur INLLQQVGKGRYGEVWMGTWQGDTVAVKIFSSIDEKSWFRETEIYNTVMLRHENILAFFA BMPR1_Spur VQLIRKIGKGRYGEVWKAKWRGENVAVKIYFTAEEASWFRETDIYQTVLMRHTSILSFIA AqueK680_Aque ILLGESIGGGRFGQVYVGHYQGERYAVKKFFSKDEQSWFHESDIYNSVNLRHDNILTCFA AqueK681_Aque ITIHEHLGRGTYGSISRCTYRGNTFAVKRFTTINESSFRRELGIYSF-SLTQTNILTYIA AqueK682_Aque VTKISVIGQGRFGKVWRCSYEEKHIAMKVFKNMHMAVFKREVEIYDTYMLYHENILRFIG : :* * :*.: : *:* : . : .* ::. : : .:* .. TGFbR1_Hsap ADNKD-NGTWTQLWLVSDYHEHGSLFDYLNR-YT-VTVEGMIKLALSTASGLAHLHMEIV BMPR1B_Mmus ADIKG-TGSWTQLYLITDYHENGSLYDYLKS-TT-LDAKSMLKLAYSSVSGLCHLHTEIF BMPR1A_Mmus ADIKG-TGSWTQLYLITDYHENGSLYDFLKC-AT-LDTRALLKLAYSAACGLCHLHTEIY ALK7_Mmus ADNKD-NGTWTQLWLVSEYHEQGSLYDYLNR-NI-VTVAGMVKLALSIASGLAHLHMEIV ALK4_Mmus ADNKD-NGTWTQLWLVSDYHEHGSLFDYLNR-YT-VTIEGMIKLALSAASGLAHLHMEIV ALK2_Mmus SDMTS-RHSSTQLWLITHYHEMGSLYDYLQL-TT-LDTVSCLRIVLSIASGLAHLHIEIF ALK1_Mmus SDMTS-RNSSTQLWLITHYHEHGSLYDFLQR-QT-LEPQLALRLAVSAACGLAHLHVEIF daf-1_Cele SDRVD-TGFVTELWLVTEYHPSGSLHDFLLE-NT-VNIETYYNLMRSTASGLAFLHNQIG BMPR1A_Hsap ADIKG-TGSWTQLYLITDYHENGSLYDFLKC-AT-LDTRALLKLAYSAACGLCHLHTEIY BMPR1B_Hsap ADIKG-TGSWTQLYLITDYHENGSLYDYLKS-TT-LDAKSMLKLAYSSVSGLCHLHTEIF ALK7_Hsap ADNKD-NGTWTQLWLVSEYHEQGSLYDYLNR-NI-VTVAGMIKLALSIASGLAHLHMEIV ALK4_Hsap ADNKD-NGTWTQLWLVSDYHEHGSLFDYLNR-YT-VTIEGMIKLALSAASGLAHLHMEIV tkv_Dmel ADIKG-NGSWTQMLLITDYHEMGSLHDYLSM-SV-INPQKLQLLAFSLASGLAHLHDEIF SAX_Dmel SDMTS-RNSCTQLWLMTHYYPLGSLFDHLNR-NA-LSHNDMVWICLSIANGLVHLHTEIF BABO_Dmel ADNKD-NGTWTQLWLVTDYHENGSLFDYLTT-HP-VDTNTMLNMSLSIATGLAHLHMDIV TGFBR1_Mmus ADNKD-NGTWTQLWLVSDYHEHGSLFDYLNR-YT-VTVEGMIKLALSTASGLAHLHMEIV sma-6_Cele ADIWSEEDSMTKMLLITDYHELGSLSDYLCREET-LTTDEALRLIHSCICGIEHLHAAVH ALK2_Hsap SDMTS-RHSSTQLWLITHYHEMGSLYDYLQL-TT-LDTVSCLRIVLSIASGLAHLHIEIF ALK1_Hsap SDMTS-RNSSTQLWLITHYHEHGSLYDFLQR-QT-LEPHLALRLAVSAACGLAHLHVEIF TGFbR1_Spur ADNKD-NGTWTQLILVSDYHENGSLFDYLNS-HV-IDVPGMLRMALSIATGLAHLHMEIM ALK2_Spur SDMTS-RQSCTQLWLIMEYHERGSLYDYLNR-HV-LDARQMCRLALTACSGLVHLHTEIT BMPR1_Spur ADIRG-SGAYTQLFLITEYHEWGSLYDFLNV-NI-LDSQSMLRLAYSAANGLAHLHTEIC AqueK680_Aque TDMLS-NNGVTELWLITQYHPRGSLFEELNR-GG-LTPETTLKFIHSTCRGLAYLHLEIT AqueK681_Aque ADMIT-IDGVMECWLILQYCPRGSLYMELTS-SP-PSLETGVRMVYSACMGLSYLHSSLQ AqueK682_Aque HDQIE-FADTIELRLYTEYHENGTLQDYLKS-KPVFHFPECHQMAVSLSSGLTYLHKTIV * : * .* *:* * : : *: .** : TGFbR1_Hsap --GTQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSAT-DTID-IAPNHRVGT BMPR1B_Mmus --STQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDT-NEVD-IPPNTRVGT BMPR1A_Mmus --GTQ--GKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDT-NEVD-IPLNTRVGT ALK7_Mmus --GTQ--GKPAIAHRDIKSKNILVKKCDTCAIADLGLAVKHDSIM-NTID-IPQNPKVGT ALK4_Mmus --GTQ--GKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVT-DTID-IAPNQRVGT ALK2_Mmus --GTQ--GKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQST-NQLD-VGNNPRVGT ALK1_Mmus --GTQ--GKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSS-DYLD-IGNNPRVGT daf-1_Cele --GSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSLSKPEDAASDII-ANENYKCGT BMPR1A_Hsap --GTQ--GKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDT-NEVD-VPLNTRVGT BMPR1B_Hsap --STQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDT-NEVD-IPPNTRVGT ALK7_Hsap --GTQ--GKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSIL-NTID-IPQNPKVGT ALK4_Hsap --GTQ--GKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVT-DTID-IAPNQRVGT tkv_Dmel --GTP--GKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSEL-DVIH-IAQNPRVGT SAX_Dmel --GKQ--GKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVT-GQLD-LGNNPKVGT BABO_Dmel --GTR--GKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKN-DSVD-IPSTHRVGT TGFBR1_Mmus --GTQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSAT-DTID-IAPNHRVGT sma-6_Cele --GTGSFRKPEIAHRDIKSKNIIVKRPNVCCIADLGLALRYQND--KILP-EKFNVQVGT ALK2_Hsap --GTQ--GKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQST-NQLD-VGNNPRVGT ALK1_Hsap --GTQ--GKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGS-DYLD-IGNNPRVGT TGFbR1_Spur --GMQ--GKPAIAHRDIKSKNILVKRNGQCAIADLGLAVRHDSVT-DTVD-IFPNNRIGT ALK2_Spur --CNN--SKPAIAHRDIKTKNILVKRNLTCCIADLGLAVLHTQRE-DNID-MGTNTRVGT BMPR1_Spur --GMQ--GKPAIAHRDVKSSNIMVRKNGTCMIADMSLAARFLSEG-NEID-LGQNTRLGT AqueK680_Aque --GTQ--GKPSVAHRDIKSKNILVKNDSTCCIADFGLAVNYL-------N-FNNNVQQGT AqueK681_Aque GYGPI--AKPRIAHRDIKSKNILMKTAETCCIADFGLSIADSED-F---QS-FICLKQGT AqueK682_Aque --AGK--IKPGIAHRDLKSSNILVKTDYTLCIADLGLAIKQSESG-DGVDQIPANKLSGT *. :****.*: *::: *.*:.*: ** TGFbR1_Hsap KRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI--G--------------- BMPR1B_Mmus KRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEIARRCVS--G--------------- BMPR1A_Mmus KRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCIT--G--------------- ALK7_Mmus KRYMAPEMLDDTMNLSIFESFKRADIYSVGLVYWEIARRCSV--G--------------- ALK4_Mmus KRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNS--G--------------- ALK2_Mmus KRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS--N--------------- ALK1_Mmus KRYMAPEVLDEHIRTDCFESYKWTDIWAFGLVLWEIARRTII--N--------------- daf-1_Cele VRYLAPEILNSTMQFTVFESYQCADVYSFSLVMWETLCRCED--G--------------- BMPR1A_Hsap KRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCIT--G--------------- BMPR1B_Hsap KRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVS--G--------------- ALK7_Hsap KRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSV--G--------------- ALK4_Hsap KRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNS--G--------------- tkv_Dmel RRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTK------------ SAX_Dmel KRYMAPEVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTIS--C--------------- BABO_Dmel KRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNM--G--------------- TGFBR1_Mmus KRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI--G--------------- sma-6_Cele KRYMAPELISNKLNPKDFSQFKMADIYSMALVMWEVAIRVEV--NTCEEVLTVDETSPDH ALK2_Hsap KRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS--N--------------- ALK1_Hsap KRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIV--N--------------- TGFbR1_Spur KRYMAPEVLDDTINMNHFDSFKRADVYSFGLVLWEIGRRCQV--F--------------- ALK2_Spur KRYMAPELLEETMDVRCFESFKRVDVYAFGLVMWEIARRCEV--G--------------- BMPR1_Spur TRYLPPEVLDNVLMSNTFDAFKMADMYSFGMVLWEIARRC-------------------- AqueK680_Aque KRYMPPEVIKGTIDVHSFESFLRADIYSFGLVMWEVCTRCHL--E--------------- AqueK681_Aque NRYMAPEILNETIDVKDFVSFLRADVYSFALVAWEVFNRCNIEQG--------------- AqueK682_Aque KRYMSPEILNESLDYGRFICYAQSDIYSFSLIIWEIFNCCEI--D--------------- **:.**::. : * *:::..:: ** TGFbR1_Hsap --------------------------------GIHE---DYQLPYYDLVPSDPSVEEMRK BMPR1B_Mmus --------------------------------GIVE---EYQLPYHDLVPSDPSYEDMRE BMPR1A_Mmus --------------------------------GIVE---EYQLPYYNMVPSDPSYEDMRE ALK7_Mmus --------------------------------GVVE---EYQLPYYDMVPSDPSIEEMRK ALK4_Mmus --------------------------------GVHE---DYQLPYYDLVPSDPSIEEMRK ALK2_Mmus --------------------------------GIVE---DYKPPFYDVVPNDPSFEDMRK ALK1_Mmus --------------------------------GIVE---DYRPPFYDMVPNDPSFEDMKK daf-1_Cele --------------------------------DVLPREAATVIPYIEWTDRDPQDAQMFD BMPR1A_Hsap --------------------------------GIVE---EYQLPYYNMVPSDPSYEDMRE BMPR1B_Hsap --------------------------------GIVE---EYQLPYHDLVPSDPSYEDMRE ALK7_Hsap --------------------------------GIVE---EYQLPYYDMVPSDPSIEEMRK ALK4_Hsap --------------------------------GVHE---EYQLPYYDLVPSDPSIEEMRK tkv_Dmel -------------------------------TTTCE---DYALPYHDVVPSDPTFEDMHA SAX_Dmel --------------------------------GIAE---EYKVPFYDVVPMDPSFEDMRK BABO_Dmel --------------------------------MIYD---EYQLPYYDVVQPDPSIEEMKK TGFBR1_Mmus --------------------------------GIHE---DYQLPYYDLVPSDPSVEEMRK sma-6_Cele SASSGIGESVSSSGNISRMHLQKTNVEGHSTSLKAK---QHVPPFDGIVHNDPNFDEMND ALK2_Hsap --------------------------------GIVE---DYKPPFYDVVPNDPSFEDMRK ALK1_Hsap --------------------------------GIVE---DYRPPFYDVVPNDPSFEDMKK TGFbR1_Spur --------------------------------GIYE---EFCLPYHPWVPMDPPIDDMRR ALK2_Spur --------------------------------GMVA---DYKPPFFEYVPSDPSFDDMRK BMPR1_Spur ------------------------------------------------------------ AqueK680_Aque --------------------------------GPLA---DYALPFQSQVPPDPTLDDMTE AqueK681_Aque --------------------------------GIAR---EYQLPYSDHLPNNSSIEDCRR AqueK682_Aque --------------------------------GVPR---SYQLPYCEWVPTDPDIDQMKQ TGFbR1_Hsap VVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTA-LRIKKT--L BMPR1B_Mmus IVCMKKLRPSFPNRWSSDECLRQMGKLMTECWAQNPASRLTA-LRVKKT--L BMPR1A_Mmus VVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTA-LRIKKT--L ALK7_Mmus VVCDQKLRPNLPNQWQSCEALRVMGRIMRECWYANGAARLTA-LRVKKT--I ALK4_Mmus VVCDQKLRPNVPNWWQSYEALRVMGKMMRECWYANGAARLTA-LRIKKT--L ALK2_Mmus VVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTA-LRIKKT--L ALK1_Mmus VVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTA-LRIKKT--L daf-1_Cele VVCTRRLRPTENPLWKDHPEMK-----------------------------H BMPR1A_Hsap VVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTA-LRIKKT--L BMPR1B_Hsap IVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTA-LRVKKT--L ALK7_Hsap VVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTA-LRIKKT--I ALK4_Hsap VVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTA-LRIKKT--L tkv_Dmel VVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTA-LRVKKT--L SAX_Dmel VVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPA-LRIKKT--I BABO_Dmel VVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTA-LRIKKT--L TGFBR1_Mmus VVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTA-LRIKKT--L sma-6_Cele VICVRRIRPPPDLAWKNVPALNELSKLMEDSWHSIPHFRHSA-LKLKKEMAE ALK2_Hsap VVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTA-LRIKKT--L ALK1_Hsap VVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTA-LRIKKT--L TGFbR1_Spur IVCIEKRRPPVPNRWNSHKIMESYAKVMKECWYQNGAARLTA-LRIKKT--L ALK2_Spur VACIEKLRPNIPNRWTNNTVLTSMAKLMKECWCPTASARHTS-LRVKKT--L BMPR1_Spur ---------------------------------------------------- AqueK680_Aque FIVGKEVIPEIPETWSNNELLRGMSRVMYECWYHQPTARPSA-YYIRK---K AqueK681_Aque VVVEEGTRP-VTSEWSKTRFLEKLSVTIKELWAERGSERPSIELLRKKI--E AqueK682_Aque CVCVNNRRPTIPDSWTESETLSPIAKLLDSSWATQASSRISA-LRISK---I