CLUSTAL W (1.83) multiple sequence alignment

Shk1_Ddis       ITTESILGDGSFGTVYKGRCRLKDVAVKVMLKQV-DQKTLTDFRKEVAIMSKIFHPNIVL
Shk2_Ddis       YNREAKLGSGAFGSVYKGIVRGKEVAIKKLTQTVFEENTMNEFKKEVSLMAKLRNPHLLL
Shk3_Ddis       INFEELIGTGSFGKVYKGRCRQKAVAVKLLHKQNFDAATLSAFRKEVHLMSKIYHPNICL
Shk4_Ddis       IDRTDFLGQGSFGSVYKGKCRGQEVAVKIPRKQKLSLYELTSFRHEVKIMSKIFHPNVVL
Shk5_Ddis       VK-TDLLGGGAYGKVYKATCRGKKVAVKVPKKQTLSESELKSFKNEVEIMKQIFHPNVVL
                      :* *::*.***.  * : **:*   :   .   :. *::** :* :: :*:: *

Shk1_Ddis       FLGACTSTPGKLMICTELM-KGNLESLLLDPMVK--LPLITR-MRMAKDAALGVLWLHSS
Shk2_Ddis       FMGACTA-PEDLSIVTELMPKGSVHSLLRAKEDTSDFITFKRAILIARDTVLGMTWLHAS
Shk3_Ddis       FMGACTI-PGRCVIVTELVPKGNLETLLHDQKIQ--LPLYLR-MRMARDAALGINWLHES
Shk4_Ddis       FLGACTQ-SGKMQIVTELC-QTDLEKLLHNDRTKKEFSLFRR-MQMAKDAALGMNWLHGI
Shk5_Ddis       CLGACTK-PGKVMIVSELM-QTDLEKLIHSSEVEP-PPLYER-MKMCLDAALGINWLHGI
                 :****  .    * :**  : .:..*:             * : :. *:.**: ***  

Shk1_Ddis       NPVFIHRDLKTSNLLVDANLTVKVCDFGLSQIKQRGENLKDGQDGAKGTPLWMAPEVLQG
Shk2_Ddis       N--ILHLDLKPANLLVDQNWVVKVADFGLSKYMKPDS--KDKLLGQAGSPLYMAPEMLVN
Shk3_Ddis       NPVFVHRDIKSSNLLVDENMRVKICDFGLSALKQKHKMLKD-QSSAKGTPLYMAPEVMMF
Shk4_Ddis       TR-IVHNDLKTANLLVDINLRVKVTDFGFSQIKE-GEEFQD--KAAKGTPLWMAPEVMMG
Shk5_Ddis       CN-IIHRDLKLANLMISKDKTVKIGDFGFSQVIKTGTTLSD-QKGPKGTALYMAPEVMMK
                   ::* *:* :**::. :  **: ***:*   :     .*   .  *:.*:****::  

Shk1_Ddis       RLFNEKADVYSFGLVLWQIFTRQELFPE-FDNFFKFVAAICEKQLRPSIPDDCPKSLKEL
Shk2_Ddis       QPYDGKVDVFSFSILLWELLTKQEPYNKLYSSYPQLVEGVVNKKNRPIIPDYFPTRLKDL
Shk3_Ddis       KEFNESSDVYSFGIVLWEILTRKEPFSH-HRELEKFREAVCVKHERPPIPNDCLDSLRRL
Shk4_Ddis       NPYNEKADVYSFGIILWEILTKEAPYSH-HKDYDIFFNAICNEKERPPIPADTLPSLRHL
Shk5_Ddis       HEFNEKADVYSFGLILYEMATCEELFPE-YSEIDPFYDAICNKKLRPPIPDSFPKSLKTL
                . :: . **:**.::*::: * :  : . . .   :  .:  :: ** **      *: *

Shk1_Ddis       IQKCWDPNPEVRPSFEGIVSE--L----E
Shk2_Ddis       LARCWDHYPSRRPSFAEISKQRILETILI
Shk3_Ddis       IEKCWDKEPISRPSFKEIISA--LDHVII
Shk4_Ddis       IQTCWDHNPQNRPSFSEILFR--LNEILI
Shk5_Ddis       IQKCWDHDPNKRPSFNEVTQR--MNEVLT
                :  ***  *  ****  :     :