CLUSTAL W (1.83) multiple sequence alignment TAK1_Hsap IEVEEVVGRGAFGVVCKA-KWRAK------DVAIKQIES--ESE---------------R Takl2_Dmel IQTKELIGTGFYGSVYRA-VWRNR------EIALKRIRE--GCE---------------D Takl1_Dmel KLSEKFLGAGSGGAVRKA-TFQNQ------EIAVKIFDFLEETI---------------K Tak1_Dmel ITLREKVGHGSYGVVCKA-VWRDK------LVAVKEFFA--SAE---------------Q mom-4_Cele NLNSHYLGKGTYGLVEKT-RYRKTRQDDFRPAAIKYSSQL---H---------------M TAK1_Mmus IEVEEVVGRGAFGVVCKA-KWRAK------DVAIKQIES--ESE---------------R Y105C5A.24_Cele ELNSHFLGKGTFGVVEKT-KYRKTR-----D----------------------------- TAK1_Spur IDFEKVVGKGAFGVVSKA-SWRGM------NVAVKMIES--EEE---------------I AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------LGSGAFGCVYQA-KWRSR------PVAVKYFNS--KTIG-------------DD AqueK669_Aque KPENTLIGVGASGRVRFA-THKGR------DVAVKYFRS--VS---------------EK AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ---EGLVGHGAFGSVFRA-NIRGC-----GPYAIKKLHN--RSEMQSEMEGTLFFEPLHQ AqueK672_Aque --------KGSFGSIRHAATLEGK------DVAIKYFTS--RD---------------IK AqueK673_Aque ------LGSGAFGSVYKA-KWRSR------QVAVKYFNS--KTIG-------------DD AqueK674_Aque --------QGAYGRVCRA-THEGK------DVAVKYFKS--VE---------------EK TAK1_Hsap KAFIVELRQLSR---VNHPNIVKLYGACLN----PVCLVMEYAEGGSLYNVLHGAEP-LP Takl2_Dmel KKIEREIYQLTK---ASHVNIVELYGTSRH--EGCALLLMEFVDGGSLSSFLHAKS--KP Takl1_Dmel KNAEREITHLSE---IDHENVIRVIGRASN--GKKDYLLMEYLEEGSLHNYLYGDD--KW Tak1_Dmel KDIEKEVKQLSR---VKHPNIIALHGISSY--QQATYLIMEFAEGGSLHNFLHGKV--KP mom-4_Cele ATLIREAKVMWDL--RNHPNIIKIYGLYKSP-RNGQGVVMEYMDCGSMADLLYDRT--HI TAK1_Mmus KAFIVELRQLSR---VNHPNIVKLYGACLN----PVCLVMEYAEGGSLYNVLHGAEP-LP Y105C5A.24_Cele -------------------DTYRIYGMYESH-RNGQGLVMEYMDCGCVADLIYDRK--NI TAK1_Spur KAFRVEVMQLSR---VDHPNIVKLYGACTT--Q-PVCLVMEFAEGGSLYNVLHSSQP-QP AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque PCFEREIEALTHLQSLKHPNIIRMFARGTE--GPQTFIVMEVAL-FSLDKIIHDLKK-EY AqueK669_Aque EEFEQEVLNSKAL--QNHDNIVAILGTGPN----KLFIVREFAP-YSLNRVLHGSYPHRY AqueK670_Aque ---------MNT---LRHPNVVLLLAASPS--PPKLAIVMEYVGGGSLYSHLHIDK---T AqueK671_Aque ESFMLELQSLVK---YKHRNVLSLIAISDD--GPRPCLVYEYMENGSLADCLLGKK--NV AqueK672_Aque GGYNDELTILNAL--QTHDNIVVLLGAGLSPMTKEPFVVMEFAP-YSLNRVLHGYP--RY AqueK673_Aque PSFEREIEALTHLQSLKHPNIIRMFARGTE--GPQTFMVMEIAL-FSLDKIIHELKK-EY AqueK674_Aque RGYKQELVFLKCL--QEHENIVILYGTGSSPKTKEPYIVMEFAP-YSLERVLHGSHPHRY TAK1_Hsap YYTAAHAMSWCLQCSQGVAYLHSMQ-PKALIHRDLKPPNLLLVAGGT--VLKICDFGTAC Takl2_Dmel SYSHAHAFNWAHQIAQGIAYLHGMQ-PKAVIHRDIKPLNTLLCEKGL--KLKICDFGTVV Takl1_Dmel EYTVEQAVRWALQCAKALAYLHSLD--RPIVHRDIKPQNMLLYNQHE--DLKICDFGLAT Tak1_Dmel AYSLAHAMSWARQCAEGLAYLHAMT-PKPLIHRDVKPLNLLLTNKGR--NLKICDFGTVA mom-4_Cele NYTIDHVASWMFQLSSAVDFFHSN----SQVHRDLKLQNMLLSDRYR--TMKLCDFGTFT TAK1_Mmus YYTAAHAMSWCLQCSQGVAYLHSMQ-PKALIHRDLKPPNLLLVAGGT--VLKICDFGTAC Y105C5A.24_Cele EYKMDHVASWMYQLSSAVNFFHSK----DQIHRDLKLQNMLLSHHHR--TLKICDFGTFT TAK1_Spur IYKAAHAMSWALQCAKGVDYLHSMK-PKKLIHRDLKPANLLLMSGGT--VLKICDFGTAC AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque DYNFNHFMSWTLQLALALECCHHN----SIIHRDINPTNLLLFDDGR--HLKICDFVTAK AqueK669_Aque TYEYDHVMHWARQIAVGLEYLHSV----RIIYRGVEPSNLLLFGNGS--LLKLCDFSHIP AqueK670_Aque IFSVDVIAQLLADITRGLQYLHSI----NILHRDLKSKNVLLTNPPPLCKAKLCDFGLAR AqueK671_Aque HLDWKLRLEIASQVADALNFLHRVNEPQSLIHGDVKSSNILLD-RHL--TPKLSDFGLAR AqueK672_Aque TYKNDHVMHWARQTALGLEYIHSK----RILYRDVKSSNLLLFGNGS--HLKLCDFGISC AqueK673_Aque DYNFNHFMSWTLQLALALECCHHN----SIIHRDIKPPNMLLFDDGR--CLKICDFGTAK AqueK674_Aque RYGVDHVMHWSRQTAVGLKHIHSK----RILHRDIKSSNLLLFGNGS--RLKLCDFGTCR TAK1_Hsap DI----------QTHMTNNKGSAAWMAPEVF----------------------EG---SN Takl2_Dmel DL----------SQSISCNAGTCRYKAPEVRELFDFKSNRIIINQPTGFQKVLQG---NK Takl1_Dmel DM----------SNNKTDMQGTLRYMAPEAI----------------------KH---LK Tak1_Dmel DK----------STMMTNNRGSAAWMAPEVF----------------------EG---SK mom-4_Cele SM----------HQSMTSNRGTPITMAPEVF----------------------RC---EQ TAK1_Mmus DI----------QTHMTNNKGSAAWMAPEVF----------------------EG---SN Y105C5A.24_Cele SI----------HQSMTSNRGSPITMAPEIF----------------------RC---EP TAK1_Spur DF----------QTYMTNNKGSAAWMAPEVF----------------------EG---RT AqueK667_Aque -----------------------RYTAPEVL----------------------RG---TS AqueK668_Aque LLDD--------AAFTDTFIGTPYYLAPEVV----------------------E------ AqueK669_Aque DA---------------LLCGPVRYIAPEVF----------------------LDVNSIS AqueK670_Aque MRLE--------SATMTGNVGTVHWTAPEVL----------------------NC---GR AqueK671_Aque ESLNRPTHVTTVSANSRVAMGTVAYMAPEFL----------------------RN---SK AqueK672_Aque NIET--------DATYTSGVGTPRYMAPEVI----------------------KG---TT AqueK673_Aque LLDA--------T-SADTFIGTPYYLAPEVI----------------------EG----K AqueK674_Aque NLET--------NLLYTASIGTVRYMAPEVI----------------------KG---DP *** TAK1_Hsap YS-EKCDVFSWGIILWEVITRRKPFDEI-GG-P--AFRIMWAVHN-GTRPPLI---KNLP Takl2_Dmel PD-EKCDVYSWAITFWEILSRKEPFEQY-NT----LFELYMAINE-GKRAR--------- Takl1_Dmel YT-AKCDVYSFGIMLWELMTRQLPYSHL-EN-PNSQYAIMKAISS-GEKLPMEAVRSDCP Tak1_Dmel YT-EKCDIFSWAIVLWEVLSRKQPFKGI-DN----AYTIQWKIYK-GERPPLL---TTCP mom-4_Cele YN-MKSDIYSIGIIMWQIIARNHPYRRD-LS----VPGLLYNVATANLRPQE----LECN TAK1_Mmus YS-EKCDVFSWGIILWEVITRRKPFDEI-GG-P--AFRIMWAVHN-GTRPPLI---KNLP Y105C5A.24_Cele YN-MKADIFSIGIIMWQMIARDHPYTMN-MP----ITPFLYNVATRNLRPHE----IECN TAK1_Spur YS-EKCDIFSWGVILWEVISRRKPFDDI-GG-P--AFRIMWAVHN-GRRPPLI---RNIP AqueK667_Aque YSTEKRDIFNFAITLWEMLARQEPVVTE-DD-TETIFEGLNQMAN-GRRPPLL---VGHP AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque YPLEKRDIFDFAITLWEMLARQE------------------------------------- AqueK670_Aque YH-FSADVYSFGMVLYEMVTRSIPFSHL-PP-P--A-VIVAVLIR-RERPSLS---SDCH AqueK671_Aque PS-SKTDVYAFGVVILELFTG--------------------------------------- AqueK672_Aque YD-TKCDIFSFAITLWEMLARQIPTIEGLDD-NSNIYAVFYAMAQLEKRPPLL---VGHP AqueK673_Aque HS-NKCDVYSFAVTLWEMITRHKPTLDLNQEGQPHPYNVFRTIGK-GARMPTI---IGIP AqueK674_Aque YT-TKCDIFSFAITLWEMLARQVPTIES-V--SANSYAILYQMVQ-GKRPPLL---VGHP TAK1_Hsap KPIESLMTRCWSKDPSQRPSMEEIV----------------------------------- Takl2_Dmel -------------------------D---------------------------------- Takl1_Dmel EGIKQLMECCMDINPEKRPSMKEIEK---------------------------------- Tak1_Dmel KRIEDLMTACWKTVPEDRPSMQ-------------------------------------- mom-4_Cele PILSEFYKKCWNDNADIRPTSSECVE---------------------------------- TAK1_Mmus KPIESLMTRCWSKDPSQRPSMEEIV----------------------------------- Y105C5A.24_Cele PILSNFYKRCWSDNPASRPTSADCVE---------------------------------- TAK1_Spur KPLDKL------------------------------------------------------ AqueK667_Aque SFVNELLQKCWNQDPGVRLTSTELVE---------------------------------- AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque QTFRTLFEKCTSWDPVDRPSLLSILR---------------------------------- AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque SFVNELLQKCWDQDPRLRPTSTELAE---------------------------------- AqueK673_Aque KFLWELVTKCWAQQPVDRLSFDEIVRKLKGVPYK-------------------------- AqueK674_Aque PFVNELLEKCWDQDPAVRLTSNDLVDKFNKICEHFTFGEPLTVQEDSDDEDDDEDEEDED TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque ------------------------------------------------------------ AqueK673_Aque -----------------------------------------------------------F AqueK674_Aque ESEVTEVPPPSPPLALQRTQSDMSYVKSKMAAMSTTGSTSDPPGDANNDDTGNGTTVQSQ TAK1_Hsap ----KI Takl2_Dmel ----RI Takl1_Dmel ----FL Tak1_Dmel ----YI mom-4_Cele ----YF TAK1_Mmus ----KI Y105C5A.24_Cele ----YF TAK1_Spur -----M AqueK667_Aque ----KF AqueK668_Aque -----G AqueK669_Aque -----P AqueK670_Aque --DLML AqueK671_Aque -----Q AqueK672_Aque ----EL AqueK673_Aque KNEPLL AqueK674_Aque LSEPYE