CLUSTAL W (1.83) multiple sequence alignment MST4_Hsap FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSSYV MST3_Hsap FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSPYV MST4_Mmus FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSSYV MST3_Mmus FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSPYV gck-1_Cele FTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQVLSQC-DSQYV SPS1_Scer YSIQSCIGRGNFGDVYKAVDRVTQEIVAIKVVNLEHSDEDIELLAQEIFFLAEL-KSPLI KIC1_Scer FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNI CG5169_Dmel FTKQERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIDDIQQEIMVLSQC-DSPYV YSK1_Mmus FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSPYI YSK1_Hsap FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSPYI SvkA_Ddis YVRQEKIGKGSFGEVFKGINKKTNETIAIKTIDLEDAEDEIEDIQQEINVLSQC-ESPFV 17911_Tthe ------------------------------------------------------------ YSK_Spur ------------------------------------------------------------ CC1G_11537_Ccin YQRLETIGKGAYGSVHKGKHIPTGNVVALKIINLDTPDDDVADIQREVALLTQLRDAPNI CC1G_00304_Ccin YTLLEKLGTGSFGVVYKAIHNETKQIVAIKQIDLEDSDDDISEIQQEIASLAQC-DSEYV CC1G_13722_Ccin YVKQDRIGKGSFGEVYKGYDKRTQKTVAIKIIDLESAEDEIEDIQQEIQILSQL-DSPHV AqueK239_Aque FTRLKKIGKGSLGEVFKGIDIKSKEVLSFKIIELEEPEVEIDDIPREISVQPEC-DSPYI AqueK240_Aque FTRLEKIGKGSFGEVFKGIDNQNKEVLAFKIIDLEEAEDEIEDIQQEITILSQC-DSAHV AqueK241_Aque ------------------------------------------------------------ AqueK242_Aque FTKQEKIGSGNFGEVFKGVENRSNRVVAIKIIDLENADDEIEDVQQEITVLSQC-DSLYV YSK_Smoe FDNLQLIGKGSFGDVFKGFDKELNKEVAIKVIDLEEAEDEIDEIQKEISVLSQC-RSPYI GK082_Glam YKLLKILGSGGFGSVYLALDEKTMTYVAIKTVDLEQSLSELDVVQKEVTLMTRL-MSNYT MST4_Hsap TKYYGSYLKGSKLWIIMEYLGGGSALDLLR-AG---PFDEFQIATMLKEILKGLDYLHSE MST3_Hsap TKYYGSYLKDTKLWIIMEYLGGGSALDLLE-PG---PLDETQIATILREILKGLDYLHSE MST4_Mmus TKYYGSYLKGSKLWIIMEYLGGGSALDLLR-AG---PFDEFQIATMLKEILKGLDYLHSE MST3_Mmus TKYYGSYLKDTKLWIIMEYLGGGSALDLLE-PG---PLDEIQIATILREILKGLDYLHSE gck-1_Cele TKYFGSFLKGSKLWIIMEYLGGGSALDLTK-SG---KLDESHIAVILREILKGLEYLHSE SPS1_Scer TNYIATMLEDVSMWIVMEYCGGGSCSDLLK-RSYVNGLPEEKVSFIIHEVTLGLKYLHEQ KIC1_Scer TRYYGSYLKDTSLWIIMEHCAGGSLRSLLR-P---GKIDEKYIGVIMRELLVALKCIHKD CG5169_Dmel TKYYGSFLKGTKLWIIMEYLGGGSALDLMK-AG---SFEEMHIGIILREVLKGLDYLHSE YSK1_Mmus TRYFGSYLKSTKLWIIMEYLGGGSALDLLK-PG---PLEETYIATILREILKGLDYLHSE YSK1_Hsap TRYFGSYLKSTKLWIIMEYLGGGSALDLLK-PG---PLEETYIATILREILKGLDYLHSE SvkA_Ddis TKYFGSFLKGSKLWIIMEYLAGGSVLDLMK-PG---PFDEGYIAIILRELLKGLEYLHSE 17911_Tthe ----------------MEYCGGGSLAQLIKKKG---QFQEPYITIILKEILQALSYLHSN YSK_Spur ---LGATMQGTKLWIIMEYLGGGSALDLLK-SG---AMDEIYIATILREVIKGLDYLHCE CC1G_11537_Ccin TKYFGCYMDGPRVWIVMEYAQGGSVLTLMK-ASKDGCIEEKYTSVIIREVLVALSYLHKV CC1G_00304_Ccin TKYYGSFVVHYKLWIVMEYLAGGSCLDLLK-AG---PFSEAHIAVICRELLLGLDYLHAE CC1G_13722_Ccin TKYHGSYLKGSHLWIVMEYCSGGSCSDLMK-PG---VFREEYIAIIIRELLRGLEYLHTE AqueK239_Aque AKYYGSYVKETKLWIVMEYLGGGSALDLMQ-PG---PVEEVYIATILREVLHGLDYLHTQ AqueK240_Aque TRYYGSYLxxxxxxxxxxxxxxxxxxxxxx-xx---xxxxxxxxxxxxxxxxxxxxxxxx AqueK241_Aque ------------------------------------------------------------ AqueK242_Aque TRYFGSYLKGTKLWIVMEYLGGGSARDLMQ-PG---PLEETQIATILREVLKGLEYLHTE YSK_Smoe TEYYGSFLHGTKLWIVMEYMAGGSVSDLLE-TG--NPLDELSIACIIRDLLHALDYLHSE GK082_Glam IRYYRSWCTESTLNIAMEA-GLCSVADILSIVG---PLNEATACFIMYHLVKGVAYLHES MST4_Hsap KKIHRDIKAANVLLSEQG------------------------------------------ MST3_Hsap KKIHRDIKAANVLLSEHG------------------------------------------ MST4_Mmus KKIHRDIKAANVLLSEQG------------------------------------------ MST3_Mmus KKIHRDIKAANVLLSEHG------------------------------------------ gck-1_Cele RKIHRDIKAANVLVSEHG------------------------------------------ SPS1_Scer RKIHRDIKAANILLNEEG------------------------------------------ KIC1_Scer NVIHRDIKAANVLITNEG------------------------------------------ CG5169_Dmel RKLHRDIKAANVLLSEQG------------------------------------------ YSK1_Mmus RKIHRDIKAANVLLSEQG------------------------------------------ YSK1_Hsap RKIHRDIKAANVLLSEQG------------------------------------------ SvkA_Ddis GKIHRDIKAANVLLSASG------------------------------------------ 17911_Tthe QMVHRDIKSANILIQKDG------------------------------------------ YSK_Spur RKIHRDIKAANVLLSENG------------------------------------------ CC1G_11537_Ccin PVIHRDLKAANILVTATG------------------------------------------ CC1G_00304_Ccin GTIHRDIKAANVLLSSSG------------------------------------------ CC1G_13722_Ccin GKLHRDIKAANILLSANG------------------------------------------ AqueK239_Aque GKLHRDIKASNVLFSTTG------------------------------------------ AqueK240_Aque xxxxxxxxxxxxxxxxxx------------------------------------------ AqueK241_Aque ------------------------------------------------------------ AqueK242_Aque KKLHRDIKAANILLSDRG------------------------------------------ YSK_Smoe GKIHRDIKAANILLTANG------------------------------------------ GK082_Glam KVIHRDLKCANILVTDDSTSSTVAQQPDGLAKRLIDLILGKPVSPGLFSETSRPRSSHGS MST4_Hsap -----------------------DVKLADFGVAGQLTDTQ-IKRNTFVGTPFWMAPEVI- MST3_Hsap -----------------------EVKLADFGVAGQLTDTQ-IKRNTFVGTPFWMAPEVI- MST4_Mmus -----------------------DVKLADFGVAGQLTDTQ-IKRNTFVGTPFWMAPEVI- MST3_Mmus -----------------------EVKLADFGVAGQLTDTQ-IKRNTFVGTPFWMAPEVI- gck-1_Cele -----------------------DVKVADFGVAGQLTETV-KKRITFVGSPFWMAPELI- SPS1_Scer -----------------------MVKLGDFGVSGHIRST--LKRDTFVGTPYWMAPEVVC KIC1_Scer -----------------------NVKLCDFGVAAQVNQTS-LRRQTMAGTPYWMAPEVI- CG5169_Dmel -----------------------DVKLADFGVAGQLTNTT-SKRNTFVGTPFWMAPEVI- YSK1_Mmus -----------------------DVKLADFGVAGQLTDTQ-IKRNTFVGTPFWMAPEVI- YSK1_Hsap -----------------------DVKLADFGVAGQLTDTQ-IKRNTFVGTPFWMAPEVI- SvkA_Ddis -----------------------DVKLADFGVSGQLTDQM-TKRNTFVGTPFWMAPEVI- 17911_Tthe -----------------------KVKLCDFGVSSKITNNS-QKLQTFVGTPYYMAPEVI- YSK_Spur -----------------------DVKLADFGVAGQLTETQ-IKRNTFVGTPFWMAPEVI- CC1G_11537_Ccin -----------------------KVMICDFGVSALLTTVS-SKRTTLTGTPYWMAPEVI- CC1G_00304_Ccin -----------------------KVKLADFGVAAQLTNTL---RHTFVGTPFWMAPEVI- CC1G_13722_Ccin -----------------------EVKLADFGVSGQLSGTLSAKKNTFVGTPYWMSPEVI- AqueK239_Aque -----------------------QVKLTDFGVAGQLTDTM-NKRNTIVERPFWMAPEVI- AqueK240_Aque -----------------------xxxxxxxxxxxxxxxxx-xxxxxxxxxxxxxxxxxx- AqueK241_Aque ------------------------------------------------------------ AqueK242_Aque -----------------------EVKLADFGVAGQLTDTM--KKFTFVGTPFWMAPEVI- YSK_Smoe -----------------------DVKVADFGVSAQLTRTV-SKRKTFVGTPFWMAPEVI- GK082_Glam YISTIARSFSPRPNSDSAAALSLGIKLCDFGVSTTISSTM-SKRCSFVGTPYWLSPEAI- MST4_Hsap -QQS-AYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLV-GD---FTK MST3_Hsap -KQS-AYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLE-GN---YSK MST4_Mmus -QQS-AYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLI-GD---FTK MST3_Mmus -KQS-AYDSKADIWSLGITAIELAKGEPPHSELHPMKVLFLIPKNNPPTLE-GN---YSK gck-1_Cele -KQS-SYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPPVLQ-GS--QWSK SPS1_Scer CEVD-GYNEKADIWSLGITTYELLKGLPPLSKYDPMKVMTNLPKRKPPKLQ-GP---FSD KIC1_Scer -MEGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRLE-DR--SYST CG5169_Dmel -KQS-QYDAKADIWSLGITAIELAKGEPPNSELHPMRVLFLIPKNNPPQLT-GS---YTK YSK1_Mmus -KQS-AYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPTLE-GH---HSK YSK1_Hsap -KQS-AYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLE-GQ---HSK SvkA_Ddis -KQT-GYDSKADIWSMGITALEMAKGEPPRADLHPMRALFLIPKDPPPTLE-GN---FSK 17911_Tthe -QKS-EYDFKADIWSVGITAIEMATGHPPYYDKKPEIAMSRIVSEEPPSLS-KE--TSST YSK_Spur -KQS-AYDSKADMWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPKLE-GS---YTK CC1G_11537_Ccin -QGVSAYDTKADIWSLGIMIFEMIKGTPPHSNLDKFKVMDLIPRAKPPRLQ-ES--EGSK CC1G_00304_Ccin -RQA-GYDSKADMWSLGITAIEMAKGEPPLAEYHPMRVLFLIPKAKPPTLE-GP---FSA CC1G_13722_Ccin -KQS-GYDHKADIWSLGITAIELAKGEPPYAELHPMKVLFLIPKNPPPTLE-GN---FSK AqueK239_Aque -TRT-VYDTKADIWSLGITAIELAQGQPPHADLHPIRALFLIPKSNPPELL-GN---YSE AqueK240_Aque -xxx-xxxxKADVWSLGITAIELAQGQPPHADLHPMRVLFLIPKSNPPELL-GN---YSK AqueK241_Aque ---------KADVWSLGITAIELAQGQPPHADLHPMRVLFLIPK---PELL-GN---YSK AqueK242_Aque -RQS-AYDMKADIWSLGITAIELARGEPPNSDLHPMRVLFLIPKNSPPELT-GN---FSK YSK_Smoe -QNSDGYNEKADIWSLGITTIEMAKGEPPFADLHPMRVLFLIPKNNPPQLE-DH---FSR GK082_Glam -TKN-ECDSFSDIWAVGICLYELIFGHPPHHKLSPTKAMIEIARNSSSTSLFDDKVEISK *:*::** *: * ** . .: : . : MST4_Hsap SFKEFIDACLNKDPSFRPTAKELLKHKFI MST3_Hsap PLKEFVEACLNKEPSFRPTAKELLKHKFI MST4_Mmus SFKEFIDACLNKDPSFRPTAKELLKHKFI MST3_Mmus PLKEFVEACLNKEPSFRPTAKELLKHKFI gck-1_Cele PFKEFVEMCLNKDPENRPSASTLLKHQFI SPS1_Scer AAKDFVAGCLVKTPADRPSAYNLLSFEFV KIC1_Scer SLKEFIALCLDEDPKERLSADDLLKSKFI CG5169_Dmel SFKDFVEACLNKDPENRPTAKELLKYPFI YSK1_Mmus PFKEFVEACLNKDPRFRPTAKELLKHKFI YSK1_Hsap PFKEFVEACLNKDPRFRPTAKELLKHKFI SvkA_Ddis GFKEFCALCLNKDPNQRPTAKDLLKHKFI 17911_Tthe MLINFVNCCLKYNPEQRQSAKQLLSHSFI YSK_Spur NFKDFVEVCLNKDPRHRPTAKELLKHRFI CC1G_11537_Ccin DMRDFMSYCLKESPTERLPAEELLKTKWI CC1G_00304_Ccin AFKDFVTLCLTKDPKLRPSANELLQHRFI CC1G_13722_Ccin TFREFVSYCLQRDPKERPSAKELLKHKFV AqueK239_Aque SFKEFIAICLNKDPNNRPSARDLLHHKFM AqueK240_Aque SFKEFIALCLNKDPKNRPSARDLLRHKFI AqueK241_Aque SFKEFIALCLNKDPKNRPSARELLRHKFI AqueK242_Aque PFKEFVATCLNKDPSHRPTARELLKHRFL YSK_Smoe PMKEFVSLCLKKNPAERASAKELLKHRFV GK082_Glam TCRDFAACCLDRDKTNRWPASKLLTHKWF :* ** * .* ** :.