CLUSTAL W (1.83) multiple sequence alignment p38g_Hsap YRDLQPVGSGAYGAVCSAV-DG---RTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR p38d_Hsap YVSPTHVGSGAYGSVCSAI-DK---RSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ p38b_Hsap LQGLRPVGSGAYGSVCSAY-DA---RLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK p38a_Hsap YQNLSPVGSGAYGSVCAAF-DT---KTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK P38c_Dmel YEFVRFLGGGSFGQVAKVR-LR---GTENYFAMKRLMRPFEREEDAKGTYREIRLLKHMN Mpk2_Dmel YQDLQPVGSGAYGQVSKAV-VR---GTNMHVAIKKLARPFQSAVHAKRTYRELRLLKHMD p38b_Dmel YQNLQPVGQGAYGQVCKAV-VR---GTSTKVAIKKLARPFQSAVHAKRTYRELRLLKHMD p38g_Mmus YQDLQPVGSGAYGAVCSAV-DS---RTGNKVAIKKLYRPFQSELFAKRAYRELRLLKHMR p38d_Mmus YLAPAHVGSGAYGAVCSAI-DK---RTGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMH p38b_Mmus LQGLRPVGSGAYGSVCSAY-DA---RLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK p38a_Mmus YQNLSPVGSGAYGSVCAAF-DT---KTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK pmk-3_Cele PNSIEYLGGGSFGNVIKTSAVCRDG-LRRYVAIKKMREPFFDPHHARRIFRETKLLQLMR pmk-2_Cele YNSLKPLGEGAYGVVCTAE-YE---PTGDRVAIKKFFRPFQSTIHAKRTYRELKLLRTLQ pmk-1_Cele YINLTPIGTGAYGTVCAAE-CT---RSGTRVAIKKFNRPFQSIIHARRTYRELRLLRCMC HOG1_Scer YNDLNPVGMGAFGLVCSAT-DT---LTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLR p38_Spur YVRLEPVGSGAYGQVCSTE-AEDTRQKGLRVAIKKLSRPFQTVIHAKRTYRELRLLKHMR AqueK129_Aque YREIASIGTGAYGTVCSAT-DT---HYNIKVALKKLARPFQNHVHAKRTYRELRLLKHMK AqueK130_Aque YQDMSPIGIGGFSTVCCAV-DS---ETGEKVALKKLARPFQSPVHAKRAYREIKLLKMLT AqueK131_Aque YQELTPINSGAYGQVCSAL-DT---KYGIRVAIKKLYAPFEHRHNAKKAYREMRILSHLK :. *.:. * . .*:*:: ** *: :** :* : p38g_Hsap H--ENVIGLLDVFTPD---ETLDDFTDFYLVMPFMGTDLGKLMKH------EKLGEDRIQ p38d_Hsap H--ENVIGLLDVFTPA---SSLRNFYDFYLVMPFMQTDLQKIMGM-------EFSEEKIQ p38b_Hsap H--ENVIGLLDVFTPA---TSIEDFSEVYLVTTLMGADLNNIVKC------QALSDEHVQ p38a_Hsap H--ENVIGLLDVFTPA---RSLEEFNDVYLVTHLMGADLNNIVKC------QKLTDDHVQ P38c_Dmel H--RNVISLLNVFHPP--AHNMMEFQQVYLVTHLMDADLHRYSRS------KRMSDQEIR Mpk2_Dmel H--ENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIRM------QHLSDDHVQ p38b_Dmel H--ENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIRT------QKLSDDHVQ p38g_Mmus H--ENVIGLLDVFTPD---ESLDDFTDFYLVMPFMGTDLGKLMKH------ETLSEDRIQ p38d_Mmus H--ENVIGLLDVFTPA---SSLRSFHDFYLVMPFMQTDLQKIMGM-------EFSEDKVQ p38b_Mmus H--ENVIGLLDVFTPA---TSIEDFSEVYLVTTLMGADLNNIVKC------QALSDEHVQ p38a_Mmus H--ENVIGLLDVFTPA---RSLEEFNDVYLVTHLMGADLNNIVKC------QKLTDDHVQ pmk-3_Cele H--DNIICALDIYTPD---EE-NDFRDVYVVTEFAGRSLYQILKQQRDYGRRVLTDEHIK pmk-2_Cele H--DNVLEMIDVFTPD---PDASSLNNVYFVSVLMGSDLQNIMKI------QRLTDEQIQ pmk-1_Cele H--ENIIDLLDVFTPN---ENVNDIEDVYFVSMLMGADLSNILKI------QRLNDDHIQ HOG1_Scer H--ENLICLQDIFL--------SPLEDIYFVTELQGTDLHRLLQT------RPLEKQFVQ p38_Spur H--ENVISLLDCFTPD---R--VNFSDVYMVTHLMGADLNNIIKC------QKLSDDHVQ AqueK129_Aque H--ENIIGLLDVFTPA---ENYENFQDVYLVMHLMGSDINNILKQ------QALTDEHVQ AqueK130_Aque RSNANVVELLDVFTPN---DSLDSFNDIYLVTCFMQSDLDNAIKI------QPITDDQVQ AqueK131_Aque H--ENCIGLLDVFSPC---EDIEEFSDFYMVMHLMSMDLAKLLKENRT--SQILSEDHIK : * : : : : :.*.* : .: . : .: :: p38g_Hsap FLVYQMLKGLRY-----------------------------IHAAGIIHRDLKPGNLAVN p38d_Hsap YLVYQMLKGLKY-----------------------------IHSAGVVHRDLKPGNLAVN p38b_Hsap FLVYQLLRGLKY-----------------------------IHSAGIIHRDLKPSNVAVN p38a_Hsap FLIYQILRGLKY-----------------------------IHSADIIHRDLKPSNLAVN P38c_Dmel IILYQILRGLKY-----------------------------IHSAGVVHRDLKPCNIAVN Mpk2_Dmel FLVYQILRGLKY-----------------------------IHSAGVIHRDLKPSNIAVN p38b_Dmel FLVYQILRGLKY-----------------------------IHSAGVIHRDLKPSNIAVN p38g_Mmus FLVYQMLKGLKY-----------------------------IHAAGVIHRDLKPGNLAVN p38d_Mmus YLVYQMLKGLKY-----------------------------IHSAGIVHRDLKPGNLAVN p38b_Mmus FLVYQLLRGLKY-----------------------------IHSAGIIHRDLKPSNVAVN p38a_Mmus FLIYQILRGLKY-----------------------------IHSADIIHRDLKPSNLAVN pmk-3_Cele FIIYQIIRALKY-----------------------------IHSANIIHRDLKPGNLALT pmk-2_Cele LLIYQVLRGLKYMSHQNFNSTIILKKLMHPFQRRNTRFRLYIHSAGIIHRDLKPSNIAVN pmk-1_Cele FLVYQILRGLKY-----------------------------IHSADIIHRDLKPSNIAVN HOG1_Scer YFLYQILRGLKY-----------------------------VHSAGVIHRDLKPSNILIN p38_Spur FLIYQVLRGLKY-----------------------------IHSAGVIHRDLKPSNIAVN AqueK129_Aque FLVYQILRGLKY-----------------------------VHSAGIVHRDLKPSNIAVN AqueK130_Aque LLVYQILRGLKY-----------------------------IHSAGVIHRDIKPSNIGVS AqueK131_Aque FLLYQILCGLKY-----------------------------VHSAGIIHRDLKPSNIAVN ::**:: .*:* :*:*.::***:** *: :. p38g_Hsap EDCEL-----------------KILDFGLARQ---ADSEMTGYVVTRWYRAPEVILN-WM p38d_Hsap EDCEL-----------------KILDFGLARH---ADAEMTGYVVTRWYRAPEVILS-WM p38b_Hsap EDCEL-----------------RILDFGLARQ---ADEEMTGYVATRWYRAPEIMLN-WM p38a_Hsap EDCEL-----------------KILDFGLARH---TDDEMTGYVATRWYRAPEIMLN-WM P38c_Dmel GNSEV-----------------RILDFGLSRM---CADKMTDHVGTMWYLAPEIIFL-RG Mpk2_Dmel EDCEL-----------------RILDFGLARP---TENEMTGYVATRWYRAPEIMLN-WM p38b_Dmel EDCEL-----------------RILDFGLARP---AESEMTGYVATRWYRAPEIMLN-WM p38g_Mmus EDCEL-----------------KILDFGLARQ---ADSEMTGYVVTRWYRAPEVILN-WM p38d_Mmus EDCEL-----------------KILDFGLARH---TDTEMTGYVVTRWYRAPEVILS-WM p38b_Mmus EDCEL-----------------RILDFGLARQ---ADEEMTGYVATRWYRAPEIMLN-WM p38a_Mmus EDCEL-----------------KILDFGLARH---TDDEMTGYVATRWYRAPEIMLN-WM pmk-3_Cele DDSDL-----------------MILDFGLARSLEKKDTSLTQYVQTRWYRSPEVIYWKID pmk-2_Cele ERCEVKVFLSFSQLSFLILSFFKILDFGLARA---QDAEMTGYVATRWYRAPEIMLN-WM pmk-1_Cele EDCEL-----------------KILDFGLARQ---TDSEMTGYVATRWYRAPEIMLN-WM HOG1_Scer ENCDL-----------------KICDFGLARI---QDPQMTGYVSTRYYRAPEIMLT-WQ p38_Spur EDCEL-----------------RILDFGLARS---TDDEMTGYVATRWYRAPEIMLN-WM AqueK129_Aque EDCEL-----------------RILDFGLARA---TDQEMTGYVATRYWRAPEIMLN-WM AqueK130_Aque SDLEI-----------------KILDFGLGRK---KKGEMTGYVTTRFWRAPEVLLQ-WM AqueK131_Aque PTCDL-----------------RILDFGLARQ---TDRDMTGYVSTRHYRAPEIMLS-WE :: * ****.* .:* :* * : :**:: p38g_Hsap RYTQ-TVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDE--- p38d_Hsap HYNQ-TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA--- p38b_Hsap HYNQ-TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEH--- p38a_Hsap HYNQ-TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES--- P38c_Dmel QYTK-AIDVWSVGCILAELITDRVLFRGENYVSQIRCLINIMGTPTREFITGISMER--- Mpk2_Dmel HYDQ-TVDIWSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSES--- p38b_Dmel HYNQ-TADIWSVGCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISSES--- p38g_Mmus RYTQ-TVDIWSVGCIMAEMITGKILFKGNDHLDQLKEIMKITGTPPPEFVQKLQSAE--- p38d_Mmus HYNQ-TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGAEFVQKLKDKA--- p38b_Mmus HYNQ-TVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEH--- p38a_Mmus HYNQ-TVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRMPSHE--- pmk-3_Cele SYTN-LADMWSLGCIAAELLTGEPLFPGDEPNAQYQRITQLCGSPDEELLTKIENDNSSA pmk-2_Cele HYTQ-TVDVWSVGCILAELVSGRPLFPGDDHIDQLTKIMSVVGTPKEEFWSKIQSEE--- pmk-1_Cele HYTQ-TVDVWSVGCILAELITGKTLFPGSDHIDQLTRIMSVTGTPDEEFLKKISSEE--- HOG1_Scer KYDV-EVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSEN--- p38_Spur HYTE-KVDIWSVGCIMAELLTQKTLFPGCDHIDQLNKIIAITGKPDETFLQKIASES--- AqueK129_Aque HYGKEGFDMWSVGCIMAELLTGQVLFPGSDHIDQLTKILQIVGTPDQEFVTKITSDT--- AqueK130_Aque HYDQ-KVDIWSVGCILAELLTGRVLFFGKNYRDHLNTILQICGTPDEEMMSKIDSDD--- AqueK131_Aque NYGK-QVDVWSVGCIMAELLGSKVLFPGDNQIDQLHKIFEIMGTPSQSLIDKIPHQK--- * *:** *** **:: . ** * : : : : * * . : p38g_Hsap AKNYMKGLPELEKKDFASILTNASPL--AVNLLEKMLVLDAEQRVTAGEALAHPYF p38d_Hsap AKSYIQSLPQTPRKDFTQLFPRASPQ--AADLLEKMLELDVDKRLTAAQALTHPFF p38b_Hsap ARTYIQSLPPMPQKDLSSIFRGANPL--AIDLLGRMLVLDSDQRVSAAEALAHAYF p38a_Hsap ARNYIQSLTQMPKMNFANVFIGANPL--AVDLLEKMLVLDSDKRITAAQALAHAYF P38c_Dmel SRNYLEGYPLRQRCDFHHLFMGYDVQ--AIDLMEKMLEMVPEKRITAAEAMLHPYL Mpk2_Dmel ARSYIQSLPPMKGRSFKNVFKNANPL--AIDLLEKMLELDAEKRITAEEALSHPYL p38b_Dmel ARNYIRSLPVMPRRNFRDIFRGANPL--AIDLLEKMLELDADKRITAEQALAHPYM p38g_Mmus AKNYMEGLPELEKKDFASVLTNASPQ--AVNLLERMLVLDAEQRVTAAEALTHPYF p38d_Mmus AKSYIQSLPQSPKKDFTQLFPRASPQ--AADLLDKMLELDVDKRLTAAQALAHPFF p38b_Mmus ARTYIQSLPPMPQKDLSSVFHGANPL--AIDLLGRMLVLDSDQRVSAAEALAHAYF p38a_Mmus ARNYIQSLAQMPKMNFANVFIGANPL--AVDLLEKMLVLDSDKRITAAQALAHAYF pmk-3_Cele IKAVIQSYTTHKRRNFRDVFSAHNPSEDFIDLLEKLLVLDPEKRITVEEAIQHPYL pmk-2_Cele ARNYIKNRSPIIRQDFVTLFPMASPY--ALELLEMMLILDPDRRISVSSALRHDYL pmk-1_Cele ARNYIRNLPKMTRRDFKRLFAQATPQ--AIDLLEKMLHLDPDRRPTAKEAMEHEYL HOG1_Scer TLKFVTSLPHRDPIPFSERFKTVEPD--AVDLLEKMLVFDPKKRITAADALAHPYS p38_Spur AKTYLMSMAAYPKRDFSTIFLGASRK--AVDLLEKMLQLDEDRRLSAEQALQHPYL AqueK129_Aque ARSYIESLPKYPKKDFHTFFQGANPL--AIDLLQMLLTIDPDKRITAEQALLHPYM AqueK130_Aque ARTYIRSLPTFAKKNFKEYFTGANPL--AVDLLEKLLHLDPDRRPSAAEALEHPYF AqueK131_Aque TKLYLQSLKVIKPKNLKNLLEIHNND--ALDLLKKLLTLDPERRITVEEALSHPYL : . : : :*: :* : .:* :. .*: * :