CLUSTAL W (1.83) multiple sequence alignment SNF1A_Dmel MPQM-----------RAAAAE--------------------------------------- AMPKa2_Mmus MAEK-------------------------------------------------------- AMPKa1_Mmus MRRL-----------SSWRKM--------------------------------------- SNF1_Scer MSSN-----------NNTNTA--------------------------------------- AMPKa2_Hsap MAEK-------------------------------------------------------- AMPKa1_Hsap MRRL-----------SSWRKM--------------------------------------- T01C8.1_Cele MFSH-----------QDRDRDRKEDGGGDGTEMKSKSRSQPSGLNRVKNLSRKLSAKSRK Snf1_Ddis MSSY-----------QQNPIG--------------------------------------- 1110_Tthe MVQQ-----------NESATE--------------------------------------- 11543_Tthe MAEP-----------DAPKAA--------------------------------------- 20428_Tthe MTST-----------NSG------------------------------------------ 21336_Tthe MSNK-----------QNIDKH--------------------------------------- 26498_Tthe MNQA-----------PE------------------------------------------- 4451_Tthe MSQV-----------RQNMQG--------------------------------------- 7432_Tthe MQQT-----------EQQHKQ--------------------------------------- 27742_Tthe MSQV-----------QQQAQS--------------------------------------- AMPK_Spur MTTI-------------------------------------------------------- aak-1_Cele MPPS-----------GRFDRT--------------------------------------- CC1G_10117_Ccin MDES-------------------------------------------------------- AqueK057_Aque MDSI-----------ME------------------------------------------- AMPK_f_Smoe MRFNLILTWGGFSSGMDRPIV--------------------------------------- AMPK_e_Smoe MSSR-----------G-------------------------------------------- AMPK_a_Smoe MDGK-------------------------------------------------------- AMPK_d_Smoe MDGK-----------A-------------------------------------------- AMPK_b-1_Smoe MDQQ-----------QEQQ----------------------------------------- AMPK_b-2_Smoe MDQQ-----------QQQQ----------------------------------------- AMPK_c_Smoe FSSG-----------MDRPIV--------------------------------------- GK014_Glam MSDQ-------------------------------------------------------- GK013_Glam MSST-----------TTG------------------------------------------ GK015_Glam MPKT-----------DKVADR--------------------------------------- : SNF1A_Dmel --------------------A----------------------VA--------------- AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus --------------------A----------------------T---------------- SNF1_Scer --------------------P----------------------ANANSSHHHHHHHHHHH AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap --------------------A----------------------T---------------- T01C8.1_Cele ERKDRDSTDNSSKMSSPGGET----------------------ST--------------- Snf1_Ddis --------------------S----------------------FGGLY------------ 1110_Tthe --------------------K----------------------STN-------------- 11543_Tthe --------------------S-EQQNQNGAKGESNAAVRGQSNSQH-------------- 20428_Tthe ------------------------------------------------------------ 21336_Tthe --------------------D-DQR------------VPS--QQDS-------------- 26498_Tthe ------------------------------------------------------------ 4451_Tthe ------------------------------------------------------------ 7432_Tthe --------------------N-QQRH-----------QLS--LSNS-------------- 27742_Tthe --------------------Q----------------------SNS-------------- AMPK_Spur ------------------------------------------------------------ aak-1_Cele --------------------I--------------------------------------- CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe --------------------A--------------------------------------- AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe --------------------A--------------------------------------- GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam --------------------AVDDA------------CPPD-ASRE-------------- SNF1A_Dmel ------------AG--------------------------------------------SA AMPKa2_Mmus -----------------------------------------------------------Q AMPKa1_Mmus ------------AE--------------------------------------------KQ SNF1_Scer HHGHGGSNSTLNNP--------------------------------------------KS AMPKa2_Hsap -----------------------------------------------------------Q AMPKa1_Hsap ------------AE--------------------------------------------KQ T01C8.1_Cele ------------KQ--------------------------------------------QQ Snf1_Ddis ------------GS--------------------------------------------GG 1110_Tthe ------------NNNVVLPLEENRERQNQTTQSTKNNESINANGIKIENPLIKNGIPVVP 11543_Tthe ------------NN--------------------------------------------HH 20428_Tthe ------------------------------------------------------------ 21336_Tthe ------------QQ---------------------------------------------H 26498_Tthe ------------------------------------------------------------ 4451_Tthe -----------------------------------------------------------S 7432_Tthe ------------PT--------------------------------------------NR 27742_Tthe ------------QQ--------------------------------------------LN AMPK_Spur ------------------------------------------------------------ aak-1_Cele ----------------------------------------------------------AL CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque -----------------------------------------------------------G AMPK_f_Smoe ----------------------------------------------------------RN AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ----------------------------------------------------------RN GK014_Glam ------------------------------------------------------------ GK013_Glam -------------S--------------------------------------------ST GK015_Glam ------------DQ--------------------------------------------DT SNF1A_Dmel NGQPLVKIGHYLL----------------------------------------------- AMPKa2_Mmus KHDGRVKIGHYVL----------------------------------------------- AMPKa1_Mmus KHDGRVKIGHYIL----------------------------------------------- SNF1_Scer SLADGAHIGNYQI----------------------------------------------- AMPKa2_Hsap KHDGRVKIGHYVL----------------------------------------------- AMPKa1_Hsap KHDGRVKIGHYIL----------------------------------------------- T01C8.1_Cele ELKAQIKIGHYIL----------------------------------------------- Snf1_Ddis IEKSSQIIGNYRL----------------------------------------------- 1110_Tthe EDKKSKSIGHYIL----------------------------------------------- 11543_Tthe QAHSIVTVGNFEI----------------------------------------------- 20428_Tthe ---NTLKIEHYLV----------------------------------------------- 21336_Tthe QKNQDQKTPAQIT----------------------------------------------- 26498_Tthe --GYFAIIGNYYV----------------------------------------------- 4451_Tthe QVEKEKTVGHYII----------------------------------------------- 7432_Tthe DSQQIKQIGNYILSKFLVKFQLSQNTNTNYLYQCKLQSIHRSIDIFYRIFYQMHFTHKFQ 27742_Tthe SIKKSKQLGNYVL----------------------------------------------- AMPK_Spur --NSGVKIGHYVL----------------------------------------------- aak-1_Cele AGTGHLKIGNFVI----------------------------------------------- CC1G_10117_Ccin QMFPPSKLGEYTV----------------------------------------------- AqueK057_Aque KTPQKLKIGRYIL----------------------------------------------- AMPK_f_Smoe FAARADLELRYRT----------------------------------------------- AMPK_e_Smoe -----SCSI--------------------------------------------------- AMPK_a_Smoe ----ANDFLNYKM----------------------------------------------- AMPK_d_Smoe -----NDFLNYKM----------------------------------------------- AMPK_b-1_Smoe -SARRTEFLHYKL----------------------------------------------- AMPK_b-2_Smoe -SARRTEFLHYKL----------------------------------------------- AMPK_c_Smoe FAARADLELRYRT----------------------------------------------- GK014_Glam -----EIIGDYLL----------------------------------------------- GK013_Glam VRVRVKRVSNYIT----------------------------------------------- GK015_Glam KKIRVKRVGNYII----------------------------------------------- SNF1A_Dmel ----GATLGTGTFGKVK------------------------------------------- AMPKa2_Mmus ----GDTLGVGTFGKVK------------------------------------------- AMPKa1_Mmus ----GDTLGVGTFGKVK------------------------------------------- SNF1_Scer ----VKTLGEGSFGKVK------------------------------------------- AMPKa2_Hsap ----GDTLGVGTFGKVK------------------------------------------- AMPKa1_Hsap ----GDTLGVGTFGKVK------------------------------------------- T01C8.1_Cele ----KETLGVGTFGKVK------------------------------------------- Snf1_Ddis ----DKTLGIGSFGKVK------------------------------------------- 1110_Tthe ----GKKLGEGTFGKVK------------------------------------------- 11543_Tthe ----GQTIGRGTFGKVK------------------------------------------- 20428_Tthe ----GKTLGCGASGKVKREQFRLFKLTFFRGVQFTLLINQSSLSSENAKIFSKKSEFKNI 21336_Tthe ----SETLGEGTFGKVK------------------------------------------- 26498_Tthe ----GKTIGRGTFGKVK------------------------------------------- 4451_Tthe ----GQNIGEGTFGKVK------------------------------------------- 7432_Tthe KNISDKTIGRGTFGKVK------------------------------------------- 27742_Tthe ----IKTLGEGAFGKVK------------------------------------------- AMPK_Spur ----GETIGMGTFGKVK------------------------------------------- aak-1_Cele ----KETIGKGAFGAVK------------------------------------------- CC1G_10117_Ccin ----IADIAEGTFGKVK------------------------------------------- AqueK057_Aque ----GETLGTGTFGKVK------------------------------------------- AMPK_f_Smoe ----ERRIGTGSFSTVV------------------------------------------- AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ----GKTLGIGSFGKVK------------------------------------------- AMPK_d_Smoe ----GKTLGIGSFGKVK------------------------------------------- AMPK_b-1_Smoe ----GKTLGIGSFGKVK------------------------------------------- AMPK_b-2_Smoe ----GKTLGIGSFGKVK------------------------------------------- AMPK_c_Smoe ----ERRIGTGSFSTVI------------------------------------------- GK014_Glam ----GRQLGTGTFGKVR------------------------------------------- GK013_Glam ----GKSLGVGTFGDVR------------------------------------------- GK015_Glam ----GKTIGEGSFSKVR------------------------------------------- SNF1A_Dmel -----IGEHQITR-------------------------------VKVA-----------V AMPKa2_Mmus -----IGEHQLTG-------------------------------HKVA-----------V AMPKa1_Mmus -----VGKHELTG-------------------------------HKVA-----------V SNF1_Scer -----LAYHTTTG-------------------------------QKVA-----------L AMPKa2_Hsap -----IGEHQLTG-------------------------------HKVA-----------V AMPKa1_Hsap -----VGKHELTG-------------------------------HKVA-----------V T01C8.1_Cele -----VGIHETTQ-------------------------------YKVA-----------V Snf1_Ddis -----LAEHIRTG-------------------------------VKVA-----------I 1110_Tthe -----LATHILTG-------------------------------EKVA-----------I 11543_Tthe -----LGIHKITN-------------------------------EKVA-----------V 20428_Tthe FCFIIVAKHDITG-------------------------------KEVA-----------I 21336_Tthe -----VATHILTG-------------------------------EKVA-----------I 26498_Tthe -----MGLHTYTMENIQLTFFTQVSINISKDNKQTLQLILNNENNKVA-----------I 4451_Tthe -----LGTHIETR-------------------------------EKVA-----------I 7432_Tthe -----LGVHTLTN-------------------------------EKVNIFSVNLSTAQTI 27742_Tthe -----LATHILTG-------------------------------EYVA-----------I AMPK_Spur -----MGEHLLTQ-------------------------------HKVA-----------I aak-1_Cele -----RGTHIQTG-------------------------------YDVA-----------I CC1G_10117_Ccin -----MAIHTVTG-------------------------------HKVA-----------M AqueK057_Aque -----IADHDLTG-------------------------------HKVA-----------V AMPK_f_Smoe -----LGEHRRSA-------------------------------RRVA-----------I AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe -----VAEHIPTG-------------------------------HKVA-----------I AMPK_d_Smoe -----VAEHIPTG-------------------------------HKVA-----------I AMPK_b-1_Smoe -----IGEHVLTG-------------------------------HKVA-----------I AMPK_b-2_Smoe -----IGEHVLTG-------------------------------HKVA-----------I AMPK_c_Smoe -----LGEHRRSA-------------------------------RRVA-----------I GK014_Glam -----VATHIPTN-------------------------------CTVA-----------I GK013_Glam -----LATHLITG-------------------------------ERVA-----------L GK015_Glam -----LGTHVLTN-------------------------------ERIA-----------L SNF1A_Dmel KILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKLYQ----------------------- AMPKa2_Mmus KILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ----------------------- AMPKa1_Mmus KILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ----------------------- SNF1_Scer KIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYD----------------------- AMPKa2_Hsap KILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ----------------------- AMPKa1_Hsap KILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ----------------------- T01C8.1_Cele KILNRQKIKSLDVVGKIRREIQNLSLFRHPHIIRLYQ----------------------- Snf1_Ddis KILNRTKIKNLKMDEKIRREIQNMKLFRHPHIIKLYE----------------------- 1110_Tthe KILEKDRIIDVSDVERVSREIHILKLLRHSNIIQLYE----------------------- 11543_Tthe KVLDKDKLIDSADKKRLQREISILRKIRHPNIIQLYE----------------------- 20428_Tthe KIINKKKMTVKKMSNKIKREIRLLRFFNHQNIIRLYE----------------------- 21336_Tthe KILEKEKIQDVSDVERVSREIHILKLLRHQNIIQLYE----------------------- 26498_Tthe KILDKDKIVDESDKIRVAREIQILRKIRHPNIIQLYEVNFQNLYFGIIQQFEQFIKYQDQ 4451_Tthe KILEKDKITEQADVERVAREIHILKILRHPNIIQLYE----------------------- 7432_Tthe KILEKRMIQGDQDMLSVQSEISILKSVNHPNISQLYQ----------------------- 27742_Tthe KILEKKKIIDVTDVERVQRELHILKMIRHPSLIQLYE----------------------- AMPK_Spur KILNRQKIKNLDVVSKIKREIQNMKLFRHPHIVKLYQ----------------------- aak-1_Cele KILNRGRMKGLGTVNKTRNEIDNLQKLTHPHITRLFR----------------------- CC1G_10117_Ccin KYISKAVIQREKTKTRVRREFEYLRTLRHPHIIKLYE----------------------- AqueK057_Aque KILNRNKIQHLDVADKITREIQILKLFRHPHIIKLYE----------------------- AMPK_f_Smoe KVMSRRNIIEGGMREKVAREVRTMALLRHPHIVRLYE----------------------- AMPK_e_Smoe -ILSRRGASRRTKPG--------------------------------------------- AMPK_a_Smoe KILNRRKIKAMDMEEKVRREIKILRLFMHPHIIRLYE----------------------- AMPK_d_Smoe KILNRRKIKAMDMEEKVRREIKILRLFMHPHIIRLYE----------------------- AMPK_b-1_Smoe KILNRRKIRAMDMEEKVRREIKILRLFMHPHIIRLYE----------------------- AMPK_b-2_Smoe KILNRRKIRAMDMEEKVRREIKILRLFMHPHIIRLYE----------------------- AMPK_c_Smoe KVMSRRNIIEGGMREKVAREVRTMALLRHPHIVRLYE----------------------- GK014_Glam KILSKSKITQMNMWSKVEREIMIMKMARHPHIINLYE----------------------- GK013_Glam KVLDKSRIQCEDDFKRIVREIQVLKLLDHSNIVRLLE----------------------- GK015_Glam KIIEKSKITEAADIERITREIQILKLLNHPNVIKLYE----------------------- :.: SNF1A_Dmel ---------VISTPSDIFMIMEYVSGGELFDYIV--K----------HGK---------- AMPKa2_Mmus ---------VISTPTDFFMVMEYVSGGELFDYIC--K----------HGR---------- AMPKa1_Mmus ---------VISTPSDIFMVMEYVSGGELFDYIC--K----------NGR---------- SNF1_Scer ---------VIKSKDEIIMVIEYA-GNELFDYIV--Q----------RDK---------- AMPKa2_Hsap ---------VISTPTDFFMVMEYVSGGELFDYIC--K----------HGR---------- AMPKa1_Hsap ---------VISTPSDIFMVMEYVSGGELFDYIC--K----------NGRKSDVPGVVKT T01C8.1_Cele ---------VISTPSDIFMIMEHVSGGELFDYIV--K----------HGR---------- Snf1_Ddis ---------VIETTTDIFMVMEYVTGGELFEYIV--K----------NGK---------- 1110_Tthe ---------IIETPKQLFLIMEYASGGELFDYIV--A----------NQR---------- 11543_Tthe ---------IIETPRQLYLFMEYAPNGELFDYIV--K----------RTR---------- 20428_Tthe ---------VLDTNTDIFVVTEYISGGDLYDVIA--S----------KGK---------- 21336_Tthe ---------IIETEKQLFLITEYASGGELFDYIV--K----------NTK---------- 26498_Tthe IVFNLLLKQIIESQTQLFLITEYAPNNELFDFIV--KRNSQLFIKNKHNR---------- 4451_Tthe ---------IIETQKQLYLIMEYAQGGELFDYIV--K----------NQK---------- 7432_Tthe ---------IIETNDCLYLVLEYAQNGELFDFIV--R----------KRR---------- 27742_Tthe ---------IIETPTHIFLVMEYCSKGEVFGYIQ--Q----------KQR---------- AMPK_Spur ---------VISTPTDIFMVMEYVAGGELFDYIV--K----------HGK---------- aak-1_Cele ---------VISTPSDIFLVMELVSGGELFSYIT--R----------KGA---------- CC1G_10117_Ccin ---------VISTPTDIIFVLEYA-GGELFNYIV--A----------NGR---------- AqueK057_Aque ---------VITTPKDIFMVMEYVSGGELFEYIV--K----------HGK---------- AMPK_f_Smoe ---------VFETPRDVLIVMEYAERGDLYEYLLVQR----------NQR---------- AMPK_e_Smoe ------------VSSSRFVLLRLV------------K----------KTE---------- AMPK_a_Smoe ---------VVETMNDIFVVMEYVKSGELFDYIV--E----------KGR---------- AMPK_d_Smoe ---------VVETANDIFVVMEYVKSGELFDYIV--E----------KGR---------- AMPK_b-1_Smoe ---------VVETSTDIFVVMEFVKSGELFDYIV--E----------NGR---------- AMPK_b-2_Smoe ---------VVETSTDIFVVMEFVKSGELFDYIV--E----------NGR---------- AMPK_c_Smoe ---------VFETPRDVLIVMEYAERGDLYEYLLVQR----------NQR---------- GK014_Glam ---------VIYREDDIYLVMEYAEGGELFSYIV--K----------HKR---------- GK013_Glam ---------VIDTPRHIYLVTEYVDNGELFNYVV--Q----------KQK---------- GK015_Glam ---------IVDTPRHVYIVQEYMNNGELFDYIV--A----------KGR---------- .. . . SNF1A_Dmel -----LQEH-QARRFFQQIISGVDYCHR-HMIVHRDLKPENLLLDH-NMHVKIADFGLSN AMPKa2_Mmus -----VEEV-EARRLFQQILSAVDYCHR-HMVVHRDLKPENVLLDA-QMNAKIADFGLSN AMPKa1_Mmus -----LDEK-ESRRLFQQILSGVDYCHR-HMVVHRDLKPENVLLDA-HMNAKIADFGLSN SNF1_Scer -----MSEQ-EARRFFQQIISAVEYCHR-HKIVHRDLKPENLLLDE-HLNVKIADFGLSN AMPKa2_Hsap -----VEEM-EARRLFQQILSAVDYCHR-HMVVHRDLKPENVLLDA-HMNAKIADFGLSN AMPKa1_Hsap GSTKELDEK-ESRRLFQQILSGVDYCHR-HMVVHRDLKPENVLLDA-HMNAKIADFGLSN T01C8.1_Cele -----LKTA-EARRFFQQIISGVDYCHR-HMVVHRDLKPENLLLDE-QNNVKIADFGLSN Snf1_Ddis -----LLED-ESRRLFQQMISGVDYCHH-HMVVHRDLKPENLLLDPINKCIKIADFGLSN 1110_Tthe -----VKER-EAARFFQQIISGIEYIHK-LNIVHRDMKPENLLLNH-DKSIKIVDFGLSN 11543_Tthe -----LSER-QASKFLQQIINGIEYMSK-IGVVHRDLKPENLLLDH-NYNIKIVDFGLSN 20428_Tthe -----LPEQ-EAKRYFKQIVAGVDYCHR-NLVAHRDLKLENILIDD-NNNIKIADFGLSN 21336_Tthe -----VQER-EASVFFQQIISGVEYIHK-LKIVHRDMKPENLLLSY-NKRIKIVDFGLSN 26498_Tthe -----LNER-QSARFLLQILSAVEYLHQ-NNIVHRDLKPENLLLDC-NNNIKVVDFGLSN 4451_Tthe -----INER-ESCKYIQQILSGVEYLHN-LNIAHRDLKPENLLLDH-QKNIKIVDFGLSN 7432_Tthe -----LTEQ-ETCLVFAQILNALEYLHD-LGISHRDLKPENLLFDY-KYELKLVDFGLSK 27742_Tthe -----LDEV-EASKFYQEILYGIEYLHK-LQVVHRDLKPENLLLDI-NHNIKIVDFGLSN AMPK_Spur -----LKEH-EARRFFQQIISGVDYCHR-HMIVHRDLKPENLLLDP-NLHVKIADFGLSN aak-1_Cele -----LPIR-ESRRYFQQIISGVSYCHN-HMIVHRDLKPENLLLDA-NKNIKIADFGLSN CC1G_10117_Ccin -----MSEA-QARRFFQQIISGIEYSHR-LKIVHRDLKPENVLLDD-DLNVKIADFGLSN AqueK057_Aque -----SSEN-ESRAFFQQIISGVDYCHR-HKVVHRDLKPENLLLDS-NNKVKIADFGLSN AMPK_f_Smoe -----LEEA-EARWFFQQLIAGVEYCHG-KSAIHRDIKVENLFLDS-QRHIKIGDFGLCN AMPK_e_Smoe -----YNSHTSPDHFWSGIL------SQ-KYGGHRDLKPENLLLDS-RCNVKIADFGLSN AMPK_a_Smoe -----LQED-EARRFNINMI---------------------------------------- AMPK_d_Smoe -----LQED-EARRFFQQIISGVEYCHR-NMVVHRDLKPENLLLDS-RCNVKIADFGLSN AMPK_b-1_Smoe -----LQED-EARCFFQQIISGVEYCHR-NMVVHRDLKPENLLLGS-KCSVKIADFGLSN AMPK_b-2_Smoe -----LQED-EARCFFQQIISGVEYCHR-NMVVHRDLKPENLLLGS-KCSVKIADFGLSN AMPK_c_Smoe -----LEEA-EARWFFQQLITGVEYCHS-KSAIHRDIKVENLFLDS-QRHIKIGDFGLCN GK014_Glam -----LDST-TARKFFQQIISALSYLHIKVSVTHRDLKPENILLTK-NKLIKLSDFGLSN GK013_Glam -----LSEE-EACKYFHQIVSALSYCHS-RKVCHRDMKLENVLLDS-SYNIKLIDFGLSN GK015_Glam -----LSEK-EACRFLCQLLNGLHFLHS-RRIVHRDLKPENLLLTA-NNDIKIIDFGLSN . :: SNF1A_Dmel M-MLDG-EFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVP AMPKa2_Mmus M-MSDG-EFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVP AMPKa1_Mmus M-MSDG-EFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVP SNF1_Scer I-MTDG-NFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIP AMPKa2_Hsap M-MSDG-EFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVP AMPKa1_Hsap M-MSDG-EFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVP T01C8.1_Cele I-MTDG-DFLRTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGTLPFDDEHVP Snf1_Ddis M-MQDG-DFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYAFLCAKLPFDDESIP 1110_Tthe T-YKKN-ELLKTACGSPCYAAPEMITGKRYNGLGVDIWSCGVILFALICGYLPFEDPVTA 11543_Tthe T-YKDN-EKLKTACGSPCYAAPEMVAGKPYNGLQTDIWSSGVILYAMLCGYLPFEDQNTS 20428_Tthe I-MNDG-KYLSTSCGSPNYAAPEVISGKLYCGTEVDTWSCGVILFALLGGYLPFDEEVIP 21336_Tthe T-YKKN-ELLKTACGSPCYAAPEMIAGKRYLGLGVDIWSCGVILFALVCGYLPFEDPNTS 26498_Tthe M-YEDG-QTLKTACGSPCYAAPEMVSGKRYEGLKTDIWSCGIILYAMLCGYLPFEDSNTT 4451_Tthe L-YKEG-ELLKTACGSPCYAAPEMIQGKKYEGLCVDIWSTGIIMFALICGYLPFEDQNTS 7432_Tthe I-CQEADQQLYTCCGSPCYASPETISSQPYVGRYVDLWSCGIILFAMLCGYLPFDDDNQA 27742_Tthe M-YKKN-ELLKTACGSPCYAAPEMIEGKKYESPQVDIWSSGVILFALLCGYLPFEDEDTR AMPK_Spur M-MTDG-EFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVP aak-1_Cele Y-MTDG-DLLSTACGSPNYAAPELISNKLYVGPEVDLWSCGVILYAMLCGTLPFDDQNVP CC1G_10117_Ccin E-ISDG-DFLTTSCGSPNYAAPEVIRGGVYAGPEIDVWSSGVILYVMLCGRLPFEDDDVQ AqueK057_Aque L-MKDG-EFLRTSCGSPNYAAPEVVSGKLYAGPEVDVWSCGIILYALLCGSLPFEDTNIS AMPK_f_Smoe T-MQEG-GFLRTSCGSTHYAAPELLLRRPYVGPEVDVWSCGVVLYVLLGGCYPFDDANTT AMPK_e_Smoe I-MRDG-HFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGSLPFDDENIP AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe I-MRDG-HFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGSLPFDDENIP AMPK_b-1_Smoe I-MRDG-HFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGSLPFDDENIP AMPK_b-2_Smoe I-MRDG-HFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGSLPFDDENIP AMPK_c_Smoe T-MQEG-GFLRTSCGSTHYAAPELLLRRPYVGPEVDVWSCGVVLYVLLGGCYPFDDANTT GK014_Glam V-MSEG-EFLKTSCGSPNYASPEVVAGTLYIGPATDIWSAGCVLYTLLVGRLPFDDHYMP GK013_Glam ILMSDE-AKFKTACGSPSYASPEMLSGKKYHGPSIDVWAIGIILFAMICGHLPFDHDNTE GK015_Glam I-FHD--TFMKTCCGSPAYAPPEMIQGKLYSGPSADLWSTGIILYAMLCGCLPFEGSTTQ SNF1A_Dmel TLFRKIKSGIFPIPEYLNK-QVVNLVCQMLQVDPLKRANIEEIKKHEWFQKDLPAYLFP- AMPKa2_Mmus TLFKKIRGGVFYIPDYLNR-SVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFP- AMPKa1_Mmus TLFKKICDGIFYTPQYLNP-SVISLLKHMLQVDPMKRAAIKDIREHEWFKQDLPKYLFP- SNF1_Scer VLFKNISNGVYTLPKFLSP-GAAGLIKRMLIVNPLNRISIHEIMQDDWFKVDLPEYLLP- AMPKa2_Hsap TLFKKIRGGVFYIPEYLNR-SVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFP- AMPKa1_Hsap TLFKKICDGIFYTPQYLNP-SVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFP- T01C8.1_Cele SLFRKIKSGVFPTPDFLER-PIVNLLHHMLCVDPMKRATIKDVIAHEWFQKDLPNYLFP- Snf1_Ddis MLFKKIREGVFSIPDFVSP-SCADLIKKMLVVDPVKRITIHEIRNHPWFQVKLPKYLSS- 1110_Tthe NLYKKITAGDFTVPKNVSN-EARDLLKSILNTDPQKRFTIEEIRNHPWCNQYKLNK-TP- 11543_Tthe VLYKKIMNQDPVLPSFLSS-NSKGILSGILTKDPEKRYNIQDIRLHPFCKEREPIL--Q- 20428_Tthe ALYKKIKA-------FFSP-EAHDIIKRMLRPNPIERIKFHELRLHPWLRENVPFYVEI- 21336_Tthe NLYKKILAGDYQIPKFVSS-EGRDLIKNILTTDPTKRFTISDIRKHPWFNQVKPNPMCE- 26498_Tthe DLYKKIINDPVKLPKFLTD-RSKSILNGILEKNPEKRLTIEAIRKHDFCILNSNQPILK- 4451_Tthe VLYKKIVSGEFSIPRWVST-EAKDLLNCILNTDPVKRYKINDIRNHKWYLLFKQNL---- 7432_Tthe SLFAKIISCEYYIPTDISP-EASYLIRGLLKKDPNQRLSIKDIKNSAFYQNYMQGTQVK- 27742_Tthe KLYDKILKGKYGIPSHVSP-DAKDLIEKILTVDPEKRMKFDQIKAHKWFNLYKRSYTIP- AMPK_Spur TLFRKIKGGHFTIPDHIERSQVKSLIQHMLQVDPLKRATIKDIREHDWFRIDMPQYLFP- aak-1_Cele TLFAKIKSGRYTVPYSMEK-QAADLISTMLQVDPVKRADVKRIVNHSWFRIDLPYYLFP- CC1G_10117_Ccin MLFHKISQGQFHCPSYLSK-DAQSLINSMLVVDPVKRATITDIINHPFFKVDLPRYLTP- AqueK057_Aque MLFRKIKSGQFYIPHYISK-GASDLLTQMLQVNPVKRITLPQIKEHTWFTTELPQYLFP- AMPK_f_Smoe TLYTKILSGTFNFPLFVPD-GPRDLISRMLTVDPRARITVAEIKEHAWFRINIPPHLSM- AMPK_e_Smoe NLFKKIKTGLYTLPSHLSP-GAKDLIPRMLLVEPMKRMTIPEIRQHPWFQAHLPRYLAV- AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe NLFKKIKTGLYTLPSHLSP-GAKDLIPRMLLVEPMKRMTIPEIRQHPWFQAHLPRYLAV- AMPK_b-1_Smoe NLFKKIKGGIYTLPSHLSS-GAKDLIPRMLLVDPMKRMTVAEIREHPWFQVNLPRYLAV- AMPK_b-2_Smoe NLFKKIKGGIYTLPSHLSS-GAKDLIPRMLLVDPMKRMTVAEIREHPWFQVNLPRYLAV- AMPK_c_Smoe TLYSKILSGTFNFPLFVPD-GPRDLISRMLTVDPRARITVAEIKEHAWFRINIPPHLSM- GK014_Glam ALFRKIKTGEYVIPDYVDS-GAADMLRGMMTVDVDKRFTIDIIRAHPWFTVNLPKHLLI- GK013_Glam TLYKKIISGVFHIPDHVSP-EAADLISKILVVDPDKRITLDEITKHPWYIQCYTGPEEP- GK015_Glam SLYIKILSGEFSTPSYLSQ-GAKDVLKALLTVNPDDRVTIEELITYPWIQKNWALNHDGR SNF1A_Dmel ---SSI-E------------------------------QDSN-----VIDTYAVAEVC-- AMPKa2_Mmus ---EDP-S------------------------------YDAN-----VIDDEAVKEVC-- AMPKa1_Mmus ---EDP-S------------------------------YSST-----MIDDEALKEVC-- SNF1_Scer -PDLKP-HPEEENENNDSKKDGS------S--------PDND-----EIDDNLVNILS-- AMPKa2_Hsap ---EDP-S------------------------------YDAN-----VIDDEAVKEVC-- AMPKa1_Hsap ---EDP-S------------------------------YSST-----MIDDEALKEVC-- T01C8.1_Cele ---PIN-E------------------------------SEAS-----IVDIEAVREVT-- Snf1_Ddis -PHTFL-S------------------------------KSIQ-----TINNSILNEMV-- 1110_Tthe -EGIIV-G------------------------------YNRI-----PVDMDILKQL--- 11543_Tthe --GIIV-G------------------------------VHEI-----PVDQNILKQLE-- 20428_Tthe -FNQNT-R------------------------------MESK-----KLNEDILRKL--- 21336_Tthe --GIIV-G------------------------------YNRI-----PIDFDIIQQL--- 26498_Tthe --GIIF-G------------------------------KDDI-----LVDPLILQIIK-- 4451_Tthe --------------------------------------SNGI-----YVNEAILQKL--- 7432_Tthe -PGIRL-G------------------------------IDFI-----YVDEAIIEKL--- 27742_Tthe -PGVIV-G------------------------------YNHM-----PIDYDIVKEL--- AMPK_Spur ---QND--------------------------------FDDS-----IVDVDAVKEVC-- aak-1_Cele ---ECE--------------------------------NESS-----IVDIDVVQSVAEK CC1G_10117_Ccin -LPPPP-GPVLGMLT-TLVAPPKQLDYEII--------DGLG-----RIEEDVVEQLAA- AqueK057_Aque ---LPG-L------------------------------TEHH-----QIDSAVLSEVC-- AMPK_f_Smoe -RSYYS--TV--------------LCFRM------------------LIDMDVLARVTQ- AMPK_e_Smoe -PPLDT-V------------------------------EQAK-----RIDEDILREVT-- AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe -PPLDT-V------------------------------EQAK-----RIDEDILREVT-- AMPK_b-1_Smoe -PPLDS-A------------------------------EQAK-----RIDEDIANEVA-- AMPK_b-2_Smoe -PPLDS-A------------------------------EQAK-----RIDEDIANEVA-- AMPK_c_Smoe -RSYYS--TV--------------LCFRMLVLEKESFPFFFS-----QIDMDVLARVTQ- GK014_Glam ---SFD--------------------------------SDPSDREEELRTTDQGQRIVDM GK013_Glam -NPE---L------------------------------KMSK-----VVDFRIIYTMV-- GK015_Glam SEPILTELP-----------------------------EISS-----DLNFGILLQM--- SNF1A_Dmel ---------------TKF------GVKETEVHNSLL---SGD---PHDQLAIAYHLIIDN AMPKa2_Mmus ---------------EKF------ECTESEVMNSLY---SGD---PQDQLAVAYHLIIDN AMPKa1_Mmus ---------------EKF------ECSEEEVLSCLY---NRN---HQDPLAVAYHLIIDN SNF1_Scer ---------------STM------GYEKDEIYESLE---SSEDTPAFNEIRDAYMLIKEN AMPKa2_Hsap ---------------EKF------ECTESEVMNSLY---SGD---PQDQLAVAYHLIIDN AMPKa1_Hsap ---------------EKF------ECSEEEVLSCLY---NRN---HQDPLAVAYHLIIDN T01C8.1_Cele ---------------ERY------HVAEEEVTSALL---GDD---PHHHLSIAYNLIVDN Snf1_Ddis ---------------QVY-----APIDRERIIEELQ---KSG---EVNDLIVSYHLLVDS 1110_Tthe ---------------ESF------SFNLDYAQKCID---A-N---KHNHVTTCYYLLLKK 11543_Tthe ----------------KY------QINVEQAEDMVK---R-N---KHNNITSVYNLLLLK 20428_Tthe ---------------AQMKNVNFHNLNEQTIRDAVI---K-R---DDYSFVIAYDLLLDD 21336_Tthe ---------------EKF------NIDKEFAKNCVE---A-N---KHNHITTSYYLLLRK 26498_Tthe ---------------NQY------GIDSEQARVMIQ---N-N---KHNQITATYYLLLNS 4451_Tthe ---------------KDF------NIDLDVARKCIE---S-N---KHNDITTTYYLLLNK 7432_Tthe ---------------SLF------GIEPSQARQSII---Q-N---HHNSITATYYLLKIK 27742_Tthe ---------------EQQ------GIDREELIKSLD---A-N---NHNNITTSYYLLLKK AMPK_Spur ---------------EKF------NVREGEVQNALM---CGD---PHDQLRIAYYLIIDN aak-1_Cele TPPEKIIYFFIFRHFLKF------DVKEEDVTGALL---AED---HHHFLCIAYRLEVNH CC1G_10117_Ccin ---------------RMI------GVSKDDIWECLR---RDDGA-QGNAVKVAYMLLRDK AqueK057_Aque ---------------QKL------SVKREEVLQALR---SGD---RGHHLAVAYELVQDN AMPK_f_Smoe -----------------L------GFERQLLIMDLL---NNESS---E------------ AMPK_e_Smoe ---------------K-L------GFDRNLLVDSLR---T-R---VANTATVTYYLMLDN AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ---------------K-L------GFDRNLLVDSLR---T-R---VANTATVTYYLMLDN AMPK_b-1_Smoe ---------------R-L------GFEKGQLIDSLR---N-R---VQNPATVTYYLMLDN AMPK_b-2_Smoe ---------------R-L------GFEKGQLIDSLR---N-R---VQNPATVTYYLMLDN AMPK_c_Smoe -----------------L------GFERQLLIMDLL---NNESS---E------------ GK014_Glam Y----------------N------ALNRQSTIDDIKRKFKAG---QTDSDTVCYQLIHDH GK013_Glam ---------------TKI-----SDWSATKIIRSLN---N-N---RHNQMTATYFLLCER GK015_Glam ---------------HRM------NLDAVECIRGLF---L-G---KHNASTATYTLLAEK SNF1A_Dmel KR------------------------FAD-DAAN--Q-----INEIN-----------NF AMPKa2_Mmus RR------------------------IMN-QAS-------------------------EF AMPKa1_Mmus RR------------------------IMN-EAK-------------------------DF SNF1_Scer KS------------------------LIK-DMKANKS-----VSDEL-----------DT AMPKa2_Hsap RR------------------------IMN-QAS-------------------------EF AMPKa1_Hsap RR------------------------IMN-EAK-------------------------DF T01C8.1_Cele KR------------------------IAD-ETAK---------LSIE-----------EF Snf1_Ddis KR------------------------GS-YE-N---E-----I---N-----------SP 1110_Tthe HI------------------------KNGGKSVA--D-----I-CSD-----------DF 11543_Tthe FI------------------------REGGKSNA--D-----L-QLM-----------KK 20428_Tthe YK------------------------KNNYYNKE--------N-NQ-------------- 21336_Tthe HI------------------------RNGGKSIA--D-----I-SSE-----------NF 26498_Tthe HI------------------------RNGGVSIA--D-----L-SRP-----------PP 4451_Tthe HV------------------------QQGGS-LE--D-----I-FPQ-----------NQ 7432_Tthe FQ------------------------RNYKQLKI--SKQKKEN-NQ--------QEQANN 27742_Tthe HM------------------------KEGGQSKA--D-----I-NSP-----------IF AMPK_Spur KR------------------------IMD-EASK---------TQMK-----------DF aak-1_Cele KR------------------------NAD-ESSQ---------KAME-----------DF CC1G_10117_Ccin NR------------------------LGK-DLAVFAE-----A--ER-----------DA AqueK057_Aque RL------------------------MQS-HTQP--------G-D-D-----------SH AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe RR------------------------RMS-HGY---L-----I---D-----------EF AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe RR------------------------RMS-HGY---L-----I---D-----------EF AMPK_b-1_Smoe RK------------------------RTGGNGN---E-----L---S-----------EV AMPK_b-2_Smoe RK------------------------RTGGNGN---E-----L---S-----------EV AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam IFDEIIARSFGIIGEPESNPAGANRSIFD-SSSL---------SALG-----------NV GK013_Glam DI------------------------QVNGYK-W------------------------NF GK015_Glam AE------------------------ATKKSN-P--K-----M-SMAAIIGINGYEKADF SNF1A_Dmel -------F---------------------------------------------------- AMPKa2_Mmus -------Y---------------------------------------------------- AMPKa1_Mmus -------Y---------------------------------------------------- SNF1_Scer -------F---------------------------------------------------- AMPKa2_Hsap -------Y---------------------------------------------------- AMPKa1_Hsap -------Y---------------------------------------------------- T01C8.1_Cele -------Y---------------------------------------------------- Snf1_Ddis -------NL--------------------------------------------------- 1110_Tthe -------DSSLLLP---NKRPAKKQYGSDLISTHEEK---ENQN----DTRCK------- 11543_Tthe -------ARS------DNLNVLKQQN-TTHLSSQQQE---QRQK----PNQIANQIVTPI 20428_Tthe ------------------------------------------------------------ 21336_Tthe -------DNTLLQP---NKPPQQNKH-ETILEDERQR---QSRK----NQRTK------- 26498_Tthe -------KKTLSLNQENNQKETNESS-SK-K--IQE------QNTILMENKDKNGLQ-QD 4451_Tthe --------PRQQQP---I---------QSQVSSRNTTSTTPNSS----AQTAT------- 7432_Tthe --------------------------DSQKVEQQKQQ---QQ------QQQLQQQ----Q 27742_Tthe -------DITLIEP---KKNNDQKY----------------------------------- AMPK_Spur -------Y---------------------------------------------------- aak-1_Cele -------WE--------------------------------------------------- CC1G_10117_Ccin -------Q---------------------------------------------------- AqueK057_Aque -------L---------------------------------------------------- AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe -------QE--------------------------------------------------- AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe -------QE--------------------------------------------------- AMPK_b-1_Smoe -------Q---------------------------------------------------- AMPK_b-2_Smoe -------QD--------------------------------------------------- AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ASGGSGDHE--------------------------------------------------- GK013_Glam -------D--------------------------EQ------------------------ GK015_Glam -------DN-----------------------LEVK------------------------ SNF1A_Dmel ----VAG-SPPPPPP--------------------------------------------- AMPKa2_Mmus ----LAS-SPPS-G---------------------------------------------- AMPKa1_Mmus ----LAT-SPPD------------------------------------------------ SNF1_Scer ----LSQ-SPPTFQQ--------------------------------------------- AMPKa2_Hsap ----LAS-SPPS-G---------------------------------------------- AMPKa1_Hsap ----LAT-SPPD------------------------------------------------ T01C8.1_Cele ----QV--TPNKGPG--------------------------------------------- Snf1_Ddis -------VSPITTPI--------------------------------------------- 1110_Tthe ------------------------------------------------------------ 11543_Tthe LQTVSTA-APPSVAATQSN-----N---------TQGQDNVTKFTIQHNQLYQIFQNYDS 20428_Tthe --NTFI-FRPVQE----------------------------------------------- 21336_Tthe ------------------------------------------------------------ 26498_Tthe KQSVNIN-YSERVSAMNKQAPNKSSTPIKKGVDNK--------PPLQNFEQYVALQQ-RI 4451_Tthe ------------------------------------------------------------ 7432_Tthe QQQIEITSSPKQNII--------------------------------------------- 27742_Tthe ------------------------------------------------------------ AMPK_Spur ----LAS-SPPPRE---------------------------------------------- aak-1_Cele -----IGKTMKMG----------------------------------------------- CC1G_10117_Ccin ----LAAQDPLTGLL--------------------------------------------- AqueK057_Aque ----LAT-SPITS----------------------------------------------- AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe -----EMASPQTGPV--------------------------------------------- AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe -----EMASPQTGPV--------------------------------------------- AMPK_b-1_Smoe ----VSRSRVKNGYH--------------------------------------------- AMPK_b-2_Smoe ----VARAFPQSFAP--------------------------------------------- AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam -----EDAMDPSGPV--------------------------------------------- GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel -------------------PPV-PQSSMDHQAPLATVTVGGGTSASSGTATPV-PPVAGG AMPKa2_Mmus -------------------SFM-DDSAM-----------------------HI-PP---- AMPKa1_Mmus -------------------SFL-DDHHL-------------------------------- SNF1_Scer -----------------QS------KS--HQKS------------------QV-DH---- AMPKa2_Hsap -------------------SFM-DDSAM-----------------------HI-PP---- AMPKa1_Hsap -------------------SFL-DDHHL-------------------------------- T01C8.1_Cele -------------------P---------------------------------------- Snf1_Ddis -----------------MSSAQ-KSPIM-----------------------FTTTT---- 1110_Tthe ------------------NSVL-NSRKES------------------------------- 11543_Tthe LKEKEDIKEFSP---AKNISYI-NPA---------------------------------- 20428_Tthe ------------------------------------------------------------ 21336_Tthe ------------------ETRI-------------------------------------- 26498_Tthe NKEKQ--KDSTPESKGKNGSYL-NSPLIQ------------------------------- 4451_Tthe ------------------GSFT-NQYNVN------------------------------- 7432_Tthe ---------------------------FS------------------------------- 27742_Tthe ------------------------------------------------------------ AMPK_Spur -------------------SYL-EVQGVEN----V----------------HT-LC---- aak-1_Cele -------------------------------------------------------S---- CC1G_10117_Ccin -----------------SP------TALSPAAT------------------EI-DS---- AqueK057_Aque -------------------SFIIVDTLLE------------------------------- AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe -----------------SAKQL-QSPFM-----------------------HI-QS---- AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe -----------------SAKQL-QSPFM-----------------------HI-QS---- AMPK_b-1_Smoe -----------------Q------------------------------------------ AMPK_b-2_Smoe -----------------QSRQM-G---------------------------RV-HS---- AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam -----------------ISQNP-FAPPE-----------------------AV-AP---- GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel TPSSTIPI-----------RP--------------------H------------PER--- AMPKa2_Mmus ------GL-----------KP--------------------H------------PER--- AMPKa1_Mmus -------T-----------RP--------------------H------------PER--- SNF1_Scer -----ETA-----------KQ--------------------H------------ARR--- AMPKa2_Hsap ------GL-----------KP--------------------H------------PER--- AMPKa1_Hsap -------T-----------RP--------------------H------------PER--- T01C8.1_Cele -------V-----------HR--------------------H------------PER--- Snf1_Ddis ------GF-----------NP--------------------S------------NSNSIS 1110_Tthe -------------------R---------------------------------------- 11543_Tthe --------------------P--------------------Q--------------A--- 20428_Tthe ------------------------------------------------------------ 21336_Tthe ------------------------------------------------------------ 26498_Tthe -------------------SP--------------------EQNSKNADARILKEDK--- 4451_Tthe -------------------Q---------------------------------------- 7432_Tthe -------------------NN--------------------------------------- 27742_Tthe ------------------------------------------------------------ AMPK_Spur ------AG-----------KP--------------------ES-----------DDR--- aak-1_Cele ------TS-----------LPVGATTKSE------------K------------SER--- CC1G_10117_Ccin -----NPFEAELNAEYEEEEEYL------------------S------------EDE--- AqueK057_Aque -------------------RD--------------------H------------SQK--- AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------QR-----------GP--------------------S------------PS---- AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------QR-----------GP--------------------S------------PS---- AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------TT---------------------------------S------------PL---- AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------AK-----------GPLLPSQEHEFSGLVFNTYVRTL------------PPT--- GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis NNNNNNNNNNNNTTNNNNNTTNNNNSIINNNNINNNNINNNNNNNNNNINNNNIINNNNN 1110_Tthe ------------------------------------------------------------ 11543_Tthe ------------------------------------------------------------ 20428_Tthe ------------------------------------------------------------ 21336_Tthe ------------------------------------------------------------ 26498_Tthe ------------------------------------------------------------ 4451_Tthe ------------------------------------------------------------ 7432_Tthe ------------------------------------------------------------ 27742_Tthe ------------------------------------------------------------ AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel ---------------------------------IAPMRDR---------Q------LA-- AMPKa2_Mmus ---------------------------------MPPLIAD-------S-P------KA-- AMPKa1_Mmus ---------------------------------VPFLVAE-------T-P------RA-- SNF1_Scer ---------------------------------MASAITQ-QRTYHQS-PFMDQYKEE-- AMPKa2_Hsap ---------------------------------MPPLIAD-------S-P------KA-- AMPKa1_Hsap ---------------------------------VPFLVAE-------T-P------RA-- T01C8.1_Cele ---------------------------------IAASVS----------S------KI-- Snf1_Ddis NNNNNNNNNNNNNNNNNNNNNNSSISGGTEVFSISPNLNN-------S-Y------NS-- 1110_Tthe ------------------------------------------------------------ 11543_Tthe ---------------------------------KPREYSH-------Q-P------REAE 20428_Tthe ------------------------------------------------------------ 21336_Tthe ------------------------------------------------------------ 26498_Tthe ---------------------------------QPFVVVK-------S-P------L--- 4451_Tthe ------------------------------------------------------------ 7432_Tthe ------------------------------------------------------------ 27742_Tthe ------------------------------------------------------------ AMPK_Spur ---------------------------------VKPALAN-------T-S------MT-- aak-1_Cele ---------------------------------NVAKVVGKF-----SAN------VG-- CC1G_10117_Ccin ---------------------------------LDSFIAA-------P-P------AT-- AqueK057_Aque ---------------------------------DS-LTNA-------S-P------V--- AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ---------------------------------LNPEA--SL-----SP-------NA-- GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe ------DHSYSYTNANNLNSKLCSSQ----------------------NSASKDVDNILN 11543_Tthe QQQNKEKHPNKYHS------------------------------------ASPTREHHIE 20428_Tthe ------------------------------------------------------------ 21336_Tthe --------SVS---------------------------------------ATKELDNQSQ 26498_Tthe ------------------------------------------------------KNKQIS 4451_Tthe ------SNNYPNSSTISQNQQ----VQNSQNSANYQNYNQQQNVSPVSVNPQQQYDPQTQ 7432_Tthe ---------------------------------------------------SPDQEKLIN 27742_Tthe --------SHNYLN--K----LIRDV----------------------KNTSEK------ AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe NNTAQLNQAN-QYKKEN------T---------NNT--------SM-------------- 11543_Tthe ------------E----------------------------------------------- 20428_Tthe ------------------------------------------------------------ 21336_Tthe Q---------------S------SN---QQTTITQN--------YEIQN----------T 26498_Tthe ------------YDES-E-----SS---NKSP---------------------------- 4451_Tthe Q---------------S------NDQIEAQKRIQQQ--------YQMQQ----------Q 7432_Tthe QNNQQNNQKQ-QNQ---NQNQGEQ----------NLNLGVA-HKPIISQQFHASLNQSNQ 27742_Tthe -KKMIQDQSG-IFDEKI------TN---TEKKGSGQ--------PLLQG----------A AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam -RKYA-EALNFELEE-DGRLIK-------------------------------------- GK015_Glam -KKIC-EEIGIEIDS-ENNILHAE---------NNTMVTIGKLKLEVSG----------D SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe ------------------------------------------------------------ 11543_Tthe ------------------------------------------------------------ 20428_Tthe ------------------------------------------------------------ 21336_Tthe SM---------------------------------------------------------- 26498_Tthe ------------------------------------------------------------ 4451_Tthe QQ---------------------------------------------------------- 7432_Tthe DINIQQYSSSSTQNLSESKSQKQNQEKQKQRIKTEPQQNNSKNQFQKVVAKNNQIAFLDL 27742_Tthe ------------------------------------------------------------ AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel ------------------------------------------------------MSV--- AMPKa2_Mmus ------------------------------------------------------RCP--- AMPKa1_Mmus ------------------------------------------------------RHT--- SNF1_Scer ------------------------------------------------------DST--- AMPKa2_Hsap ------------------------------------------------------RCP--- AMPKa1_Hsap ------------------------------------------------------RHT--- T01C8.1_Cele ------------------------------------------------------TPT--- Snf1_Ddis ------------------------------------------------------NSSGNS 1110_Tthe ------------------------------------------------------------ 11543_Tthe ------------------------------------------------------------ 20428_Tthe ------------------------------------------------------DCT--- 21336_Tthe ------------------------------------------------------------ 26498_Tthe ------------------------------------------------------------ 4451_Tthe ------------------------------------------------------------ 7432_Tthe YQKQIELNTSNEEYYNGSGVQNMRNAYVSALGNYQNQLLQISTEQESYNLNQVAQIA--- 27742_Tthe ------------------------------------------------------------ AMPK_Spur ------------------------------------------------------MNT--- aak-1_Cele ------------------------------------------------------RK---- CC1G_10117_Ccin ------------------------------------------------------DPT--- AqueK057_Aque ------------------------------------------------------SST--- AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------RKV--- GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel --------------------------------------------QT--SG---------- AMPKa2_Mmus --------------------------------------------LD--AL---------- AMPKa1_Mmus --------------------------------------------LD--EL---------- SNF1_Scer --------------------------------------------VS--IL---------- AMPKa2_Hsap --------------------------------------------LD--AL---------- AMPKa1_Hsap --------------------------------------------LD--EL---------- T01C8.1_Cele --------------------------------------------LD-------------- Snf1_Ddis NGSNSNNNSNNNTNNDNNNNNNNNNNNNNNNNNNNNNNNNNNNCID--SV---------- 1110_Tthe ----------------------------------------------------T------- 11543_Tthe ------------------------------------------------------------ 20428_Tthe --------------------------------------------VE--TNNAY------- 21336_Tthe ----------------------------------------------------N------- 26498_Tthe ----------------------------------------------------N------- 4451_Tthe ----------------------------------------------------QQQQQQQQ 7432_Tthe --------------------------------------------NL--QAQSP------- 27742_Tthe ----------------------------------------------------Y------- AMPK_Spur --------------------------------------------LE--NF---------- aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin --------------------------------------------FA--VL---------- AqueK057_Aque --------------------------------------------GG--GM---------- AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam --------------------------------------------DGAEAV---------- GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe ------------------------------------------------------------ 11543_Tthe ------------------------------------------------------------ 20428_Tthe ------------------------------------------------------------ 21336_Tthe ------------------------------------------------------------ 26498_Tthe ------------------------------------------------------------ 4451_Tthe YNPNLDQENQEAIKLQIAQFEQQQQQLIEQQQKELLLKQMQMEEEQKQKQIFLQQQQAAE 7432_Tthe ------------------------------------------------------------ 27742_Tthe ------------------------------------------------------------ AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe --------------------------------------------------ID-------- 11543_Tthe ------------------------------------------------------------ 20428_Tthe --------------------------------------------------ID-------- 21336_Tthe --------------------------------------------------MN-------- 26498_Tthe ------------------------------------------------------------ 4451_Tthe EQRRKKQQQEEQEMIRLQLLKQQQYEEELARQLQKQREEQLRIQLLEEEQQR-------- 7432_Tthe --------------------------------------------------YNTNLALIKT 27742_Tthe --------------------------------------------------IS-------- AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel -----------------------GG----------A------------------------ AMPKa2_Mmus -----------------------NTT---------------------------------- AMPKa1_Mmus -----------------------NPQ---------------------------------- SNF1_Scer -----------------------PTSLP-QIHRANMLAQ-GS------------------ AMPKa2_Hsap -----------------------NTT---------------------------------- AMPKa1_Hsap -----------------------NPQ---------------------------------- T01C8.1_Cele -----------------------NTE---------------------------------- Snf1_Ddis -----------------------NNS---------LNNE-NDVNNSNINNNNNNNSDDGS 1110_Tthe ----------------Q------------------------------------------- 11543_Tthe ----------------------N------------------------------------- 20428_Tthe -----------------Q----IFNQ---------------------------------- 21336_Tthe ----------------DL-KGTQ------------------------------------- 26498_Tthe ---------------------IS------------------------------------- 4451_Tthe ----------------AKAKLEE------------------------------------- 7432_Tthe VQFQKSNAQNQNQIVANSEN--ITPK---------------------------------- 27742_Tthe ----------------NSYTNKV------------------------------------- AMPK_Spur -----------------------NNQ---------S------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin -----------------------NSSLPEQLPEQHHLTS-YV------------------ AqueK057_Aque -----------------------TKH---------RSTS-LV------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam -----------------------SSN---------TDDGCYN------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel ----------------------------------------FP-----------------E AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ----------------------------------------PA----------------AS AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis NNNSYEGGGDVLLLSDLNGNNQLGGNDNGNVVNLNNNFQLLN----------------SL 1110_Tthe ----------------------------------------------------------KS 11543_Tthe ----------------------------------------------------------QN 20428_Tthe -----------------------------------------G----------------KL 21336_Tthe ----------------------------------------------------------NS 26498_Tthe ----------------------------------------------------------PN 4451_Tthe ----------------------------------------------------------QM 7432_Tthe -----------------------------------------NNNNNNNNNKQKNSENKQL 27742_Tthe ----------------------------------------------------------YD AMPK_Spur ----------------------------------------SE-----------------S aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ----------------------------------------SA----------------KR AqueK057_Aque ----------------------------------------IE----------------DS AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ----------------------------------------DQTKVASGGLTLAQFRDGLN GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel KTAR------GGTP---------------------------------------------- AMPKa2_Mmus --KP------KSLA---------------------------------------------- AMPKa1_Mmus --KS------KHQG---------------------------------------------- SNF1_Scer KISP------LVTK---------------------------------------------- AMPKa2_Hsap --KP------KSLA---------------------------------------------- AMPKa1_Hsap --KS------KHQG---------------------------------------------- T01C8.1_Cele --AS------GANR---------------------------------------------- Snf1_Ddis DLNS------DIQT---------------------------------------------- 1110_Tthe TANS------KYPSYKSSKRNSIQTNKLS------------------------------- 11543_Tthe QQKQ-------------------------------------------------------- 20428_Tthe EEVT------EEEE---------------------------------------------- 21336_Tthe LILS------QKNNLQRPVTN----QGINNSQLPNILNSNIIPQNVQNRKIGSRNAQN-- 26498_Tthe TNKS------KY------------------------------------------------ 4451_Tthe RQQALIEEQQKKKLLEEQQQFLLRKQKQDEEYEQNL---------------------KQQ 7432_Tthe EDLQ--------QN---------------------------------------------- 27742_Tthe NESQ------KTIKNRRGRQH--------------------------------------- AMPK_Spur QRRV------SATP---------------------------------------------- aak-1_Cele ILEG------LKKE---------------------------------------------- CC1G_10117_Ccin SARS------GEKK---------------------------------------------- AqueK057_Aque VPIR------LPRS---------------------------------------------- AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe --ND------ISRF---------------------------------------------- AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe --ND------ISRF---------------------------------------------- AMPK_b-1_Smoe --AR------CWNI---------------------------------------------- AMPK_b-2_Smoe --LE------VPRL---------------------------------------------- AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam GSLR------SEKV---------------------------------------------- GK013_Glam ------------------------------------------------------------ GK015_Glam ----------------KVGKH--------------------------------------- SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe ------------------------------------------------------------ 11543_Tthe ------------------------------------------------------------ 20428_Tthe ------------------------------------------------------------ 21336_Tthe -----------------------------------QGKIYEYPK---------------- 26498_Tthe ------------------------------------------------------------ 4451_Tthe QYLAQKQAQMQQQQQQYKQQLIQQQQQQQVPVTSNHSQKYQNPSPQQQAVTTYNEAMQIN 7432_Tthe ------------------------------------------------------------ 27742_Tthe ------------------------------------------------------------ AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe --------------------------YN-----------------------SENQYP--- 11543_Tthe ------------------------------------------------------------ 20428_Tthe ------------------------------------------------------------ 21336_Tthe ---PNSNNYFYDSQSP-SPIKPLYIAGN-----------------------QNGNDSNKS 26498_Tthe ------------------------------------------------------------ 4451_Tthe TYSPSSQ-HNYGQNQPPSFAQPFAYQNSNNLKLPEDNQFRESLSNNNNRQSAAPSFSNQT 7432_Tthe ------------------------------------------------------------ 27742_Tthe ------------------------------------------------------FYSNAS AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam --------------------------------------------------------KS-- GK015_Glam ------------------------------------------------------LHSNTS SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe ----------------------------------------------------NT---TKP 11543_Tthe ------------------------------------------------------------ 20428_Tthe ------------------------------------------------------------ 21336_Tthe EGYQNA----------------------------------------VNTINNGIFNSAIP 26498_Tthe ------------------------------------------------------------ 4451_Tthe D---SMIEINENNQAPCLNLEDFDQANSNTSLNANEQCEQVRKSIGENT--------PTP 7432_Tthe ------------------------------------------------------------ 27742_Tthe D---LA----------------------------------------INDNNTSF---TNP AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam D---AS----------------------------------------TKD----------- SNF1A_Dmel ------------------------------IKRAKWHLGIRS------------------ AMPKa2_Mmus ------------------------------VKKAKWHLGIRS------------------ AMPKa1_Mmus ------------------------------VRKAKWHLGIRS------------------ SNF1_Scer ------------------------------KSKTRWHFGIRS------------------ AMPKa2_Hsap ------------------------------VKKAKWHLGIRS------------------ AMPKa1_Hsap ------------------------------VRKAKWHLGIRS------------------ T01C8.1_Cele ------------------------------NKRAKWHLGIRS------------------ Snf1_Ddis ------------------------------QPHRKWYLGAIS------------------ 1110_Tthe VANNNYVFDGNQI--------------ANPNVHPYPQMNIHS------------------ 11543_Tthe ---------------------------------KTVELGIKD------------------ 20428_Tthe ------------------------------EILGQWTYGKIY------------------ 21336_Tthe ------------NSFKYPTHPSSMTASPRQAAQGRFESRMRQ------------------ 26498_Tthe ---------------------------------QDLQ----SSQKEKQSGEINFIKGYSL 4451_Tthe ------------KK--------------LEFNNQPNRLSIED------------------ 7432_Tthe ------------------------------NNQNSYQANLQQ------------------ 27742_Tthe ------------NST------------ISHIQNQSYHLSPSS------------------ AMPK_Spur ------------------------------VKRSKWHLGIRS------------------ aak-1_Cele ------------------------------QKKLTWNLGIRA------------------ CC1G_10117_Ccin ------------------------------QHRTKWHFGIRS------------------ AqueK057_Aque ------------------------------FKKPKWHLGIRS------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------TAERRWALGLQS------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------TAERRWALGLQS------------------ AMPK_b-1_Smoe ------------------------------GSERRWALGLQS------------------ AMPK_b-2_Smoe ------------------------------QAERRWALGLQS------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------DKKSMFYFGVTG------------------ GK013_Glam ----------------------------------------DS------------------ GK015_Glam ------------------------------------AV-AQD------------------ SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe -------------Q---------------------------------------------- 11543_Tthe -------------N---------------------------------------------- 20428_Tthe -------------S---------------------------------------------- 21336_Tthe -------------A---------------------------------------------- 26498_Tthe TESTVRKQNFFQEE---------------------------------------------- 4451_Tthe -------------QQKRSKKNSVSNSQEFKYFQKEQREEIYVANTKKSIDLTQSQRNSIQ 7432_Tthe -------------Q---------------------------------------------- 27742_Tthe -------------K---------------------------------------------- AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam -------------CNIA------------------------------------------- GK013_Glam -------------G---------------------------------------------- GK015_Glam -------------P---------------------------------------------- SNF1A_Dmel ---------QSKPND--------------------------------------------- AMPKa2_Mmus ---------QSKACD--------------------------------------------- AMPKa1_Mmus ---------QSRPND--------------------------------------------- SNF1_Scer ---------RSYPLD--------------------------------------------- AMPKa2_Hsap ---------QSKPYD--------------------------------------------- AMPKa1_Hsap ---------QSRPND--------------------------------------------- T01C8.1_Cele ---------QSRPED--------------------------------------------- Snf1_Ddis ---------QLPPHE--------------------------------------------- 1110_Tthe ----------TNQQS--------------------------------------------- 11543_Tthe ----------MVPEF--------------------------------------------- 20428_Tthe ----------NSART--------------------------------------------- 21336_Tthe ----------ANPNE--------------------------------------------- 26498_Tthe ----------EQINN--------------------------------------------- 4451_Tthe YNNFMAGEENPRPYD--------------------------------------------- 7432_Tthe ----------ASGNLISNIPLHVYHTNIQSKKTSQVDISTQKYFKYSLKKRNLCINEYSV 27742_Tthe ----------NQRNG--------------------Y------------------------ AMPK_Spur ---------QSRPHD--------------------------------------------- aak-1_Cele ---------CLDPVE--------------------------------------------- CC1G_10117_Ccin ---------RSPPME--------------------------------------------- AqueK057_Aque ---------QSHPQN--------------------------------------------- AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ---------RASPRD--------------------------------------------- AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ---------RASPRD--------------------------------------------- AMPK_b-1_Smoe ---------RAHPRE--------------------------------------------- AMPK_b-2_Smoe ---------RAHPRE--------------------------------------------- AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ---------VMPPPD--------------------------------------------- GK013_Glam ----------AKVED--------------------------------------------- GK015_Glam ----------ASDRG--------------------------------------------- SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe ------------------------------------------------------------ 11543_Tthe ------------------------------------------------------------ 20428_Tthe ------------------------------------------------------------ 21336_Tthe ------------------------------------------------------------ 26498_Tthe ------------------------------------------------------------ 4451_Tthe ------------------------------------------------------------ 7432_Tthe DNAKNYDQTPSPKDPPIFSVSQDTFYQKAQQIQQTKHQKDIQQPKVGNQLKKHSEHIKSN 27742_Tthe ------------------------------------------------------------ AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe ------------------------------------------------------------ 11543_Tthe ------------------------------------------------------------ 20428_Tthe ------------------------------------------------------------ 21336_Tthe ------------------------------------------------------------ 26498_Tthe ------------------------------------------------------------ 4451_Tthe ------------------------------------------------------------ 7432_Tthe VINNNSNHSLQKQIFYLNESDKKIETIKKIIDSVRSTKNSFNPPQQITPRMKIFSKIQNS 27742_Tthe ------------------------------------------------------------ AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe ------------------------------------------------------------ 11543_Tthe ------------------------------------------------------------ 20428_Tthe ------------------------------------------------------------ 21336_Tthe ------------------------------------------------------------ 26498_Tthe ------------------------------------------------------------ 4451_Tthe ------------------------------------------------------------ 7432_Tthe NNNTNQIHDIFSKRKSVPLYLSPQKEDVFSSSQNEAYRNIFQNNQMQSKQQQMIEESKLN 27742_Tthe -------------------------------------H---------------------- AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel ---------IMLEV--Y-RAMKAL--SY-------------------------------- AMPKa2_Mmus ---------IMAEV--Y-RAMKQL--GF-------------------------------- AMPKa1_Mmus ---------IMAEV--C-RAIKQL--DY-------------------------------- SNF1_Scer ---------VMGEI--Y-IALKNL--GA-------------------------------- AMPKa2_Hsap ---------IMAEV--Y-RAMKQL--DF-------------------------------- AMPKa1_Hsap ---------IMAEV--C-RAIKQL--DY-------------------------------- T01C8.1_Cele ---------IMFEV--F-RAMKQL--DM-------------------------------- Snf1_Ddis ---------IMGEI--Y-RALKKV--GF-------------------------------- 1110_Tthe ---------IQQQI--I-YQQQQL--QQ-------------------------------- 11543_Tthe ---------VDITH--I-QKASQA--DQKLASLLDNTQKLGNQG---------------- 20428_Tthe ---------IMKAI--Y-EVASQL--DI-------------------------------- 21336_Tthe ---------IQEPS----R-------HS-------------------------------- 26498_Tthe ---------ISATK--DKQNIQNI--DVEN--------QINNQQAYTSTFGSGFKLSEKG 4451_Tthe ---------HVLQP--E-PIPQSI--QN-------------------------------- 7432_Tthe QNNMSNQKQLSNKS--V-KTYKTLNPSM-------------------------------- 27742_Tthe ---------SVAPVNYS-QSQKAK--SY-------------------------------- AMPK_Spur ---------IMGEV--F-RAMKAL--NF-------------------------------- aak-1_Cele ---------TMKHV--F-LSLKSV--DM-------------------------------- CC1G_10117_Ccin ---------VMLEI--Y-RTLKTL--GM-------------------------------- AqueK057_Aque ---------IMQEI--M-KKLKAL--NF-------------------------------- AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ---------IMNEV--L-KVLQDM--EV-------------------------------- AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ---------IMNEV--L-KVLQDM--EV-------------------------------- AMPK_b-1_Smoe ---------IMNEV--L-KVLQEL--DV-------------------------------- AMPK_b-2_Smoe ---------IMNEV--L-KVLQEL--DV-------------------------------- AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ---------MMCLI--L-ETMREL--GF-------------------------------- GK013_Glam ---------TNADV--A-EAIEDS--HS-------------------------------- GK015_Glam ---------SQEKV--T-MKINEK--DV-------------------------------- SNF1A_Dmel EWKI-------------------------------------------------------- AMPKa2_Mmus EWKV-------------------------------------------------------- AMPKa1_Mmus EWKV-------------------------------------------------------- SNF1_Scer EWAK-------------------------------------------------------- AMPKa2_Hsap EWKV-------------------------------------------------------- AMPKa1_Hsap EWKV-------------------------------------------------------- T01C8.1_Cele EWKV-------------------------------------------------------- Snf1_Ddis EWKL-------------------------------------------------------- 1110_Tthe N----------------------------------------------------------- 11543_Tthe --------------------------------------NTN---IYLNPLQKRIPIDK-- 20428_Tthe VITI-------------------------------------------------------- 21336_Tthe S----------------------------------------------------------- 26498_Tthe S---------------PIRKVKLNNIQQQQFQQSLQKGDTNIQKCIIDKNEENIKLDKQK 4451_Tthe N----------------------------------------------------------- 7432_Tthe VWQA-------------------------------------------------------- 27742_Tthe S----------------------------------------------------------- AMPK_Spur EWKV-------------------------------------------------------- aak-1_Cele EWKV-------------------------------------------------------- CC1G_10117_Ccin EWKE-------------------------------------------------------- AqueK057_Aque DWKV-------------------------------------------------------- AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe LWKK-------------------------------------------------------- AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe LWKK-------------------------------------------------------- AMPK_b-1_Smoe SWKK-------------------------------------------------------- AMPK_b-2_Smoe SWKK-------------------------------------------------------- AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam KWRI-------------------------------------------------------- GK013_Glam D----------------------------------------------------------- GK015_Glam ELKRETAELAATVPVIPVGQAKI------------------------------------- SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe ------------------------------------------------------------ 11543_Tthe ------------------------------LKQTSYMLQSSYQKKQNNFVDANY------ 20428_Tthe ------------------------------------------------------------ 21336_Tthe -------------------------------------V---------------------- 26498_Tthe SQESENLLSEKSLSKNNEKSDDEQLAEKSPIKETKMQIEGENKIRNQNVVATETKSASLD 4451_Tthe ------------------------------------------------------------ 7432_Tthe ------------------------------------------------------------ 27742_Tthe ------------------------------------------------------------ AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ---------------------------------PGLGL---------------------- SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe ------------------------------------------------------------ 11543_Tthe --------------------ISNT-----QGSVP------------SQSKKQSIAKVNYL 20428_Tthe ------------------------------------------------------------ 21336_Tthe -------------------------------GNN-------------------------- 26498_Tthe KKQINKTNNQNQQKVNGVNNLYNIQISKLHYNKAGQKARNGQESTSEISANKSDNQVTLQ 4451_Tthe ------------------------------------------------------------ 7432_Tthe ------------------------------------------------------------ 27742_Tthe ------------------------------------------------------------ AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam -------------------------------GLN------------LPAG---------- SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe --------NYFQAN-------------------------SALTSGTQSPYKHSSQQYAPY 11543_Tthe NNSSMFEDPK-------------------------------------------------- 20428_Tthe ------------------------------------------------------------ 21336_Tthe --------TIVNQI-------------------------AGASTGSKQ-RQSKK------ 26498_Tthe NNSDIYQRTDA---------------------------------------NI-------- 4451_Tthe --------WNQHNQDNQNGTMSSNSSNYYKELQVVNQLLRD------------------S 7432_Tthe ------------------------------------------------------------ 27742_Tthe ------------------------------------------------------------ AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam --------PN-------------------------------------------------- GK015_Glam --------PV-----------------------------AGGGAVTT--RN--------- SNF1A_Dmel -I-NP---------------------------YH--VRV--R------------------ AMPKa2_Mmus -V-NA---------------------------YH--LRV--R------------------ AMPKa1_Mmus -V-NP---------------------------YY--LRV--R------------------ SNF1_Scer -P-SEED------------------------LWT--IKL--R------------------ AMPKa2_Hsap -V-NA---------------------------YH--LRV--R------------------ AMPKa1_Hsap -V-NP---------------------------YY--LRV--R------------------ T01C8.1_Cele -L-NP---------------------------YH--VIV--R------------------ Snf1_Ddis -T-GP---------------------------YQ--LRC--R------------------ 1110_Tthe AQNNH---------------------------YNYSNTG--A------------------ 11543_Tthe -DSQK---------------------------YK--VNS--S------------------ 20428_Tthe -KNSE---------------------------YR--IKC--H------------------ 21336_Tthe --------------------------------------Q--E------------------ 26498_Tthe -NVQN---------------------------YK--ISSASR------------------ 4451_Tthe QQGNT---------------------------H--HIRE--QSYSQERETKQHAQTNQAH 7432_Tthe --NEN---------------------------LQ--VKS--T------------------ 27742_Tthe ------------------------------------------------------------ AMPK_Spur -V-NP---------------------------FY--VRV--R------------------ aak-1_Cele -L-SM---------------------------YH--IIV--R------------------ CC1G_10117_Ccin -K-KNLGG-----------------------LGG--LKA--R------------------ AqueK057_Aque -V-NT---------------------------YH--IRC--R------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe -N-GN---------------------------YN--VKC--R------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe -N-GN---------------------------YN--VKC--R------------------ AMPK_b-1_Smoe -L-GH---------------------------YN--VKC--R------------------ AMPK_b-2_Smoe -L-GH---------------------------YN--VKC--R------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam -G-GLNASKYYDSNIGRDTVVLKTDTSKKRNNFC--VAF--K------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel -------------------------------------------------------RQ--- AMPKa2_Mmus -------------------------------------------------------RK--- AMPKa1_Mmus -------------------------------------------------------RK--- SNF1_Scer -------------------------------------------------------WK--- AMPKa2_Hsap -------------------------------------------------------RK--- AMPKa1_Hsap -------------------------------------------------------RK--- T01C8.1_Cele -------------------------------------------------------RK--- Snf1_Ddis -------------------------------------------------------MV--- 1110_Tthe -------------------------------------------------------RN--- 11543_Tthe -------------------------------------------------------FQ--- 20428_Tthe -------------------------------------------------------RK--- 21336_Tthe -------------------------------------------------------AV--- 26498_Tthe -------------------------------------------------------RG--- 4451_Tthe PHNSQQTQAQMLINSTIPKNTVSITSNHSISNNSQANQNNPQVQNGAAAAQQQFTSA--- 7432_Tthe -----------------------------------NS------------------ER--- 27742_Tthe ------------------------------------------------------------ AMPK_Spur -------------------------------------------------------RT--- aak-1_Cele -------------------------------------------------------SK--- CC1G_10117_Ccin -------------------------------------------------------RQHHH AqueK057_Aque -------------------------------------------------------YK--- AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe -------------------------------------------------------WN--- AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe -------------------------------------------------------WN--- AMPK_b-1_Smoe -------------------------------------------------------WT--- AMPK_b-2_Smoe -------------------------------------------------------WT--- AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam -------------------------------------------------------LV--- GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel --NV-K------------------------------------------------------ AMPKa2_Mmus --NP-V------------------------------------------------------ AMPKa1_Mmus --NP-V------------------------------------------------------ SNF1_Scer --YDIGNKT--------------------------------------------------- AMPKa2_Hsap --NP-V------------------------------------------------------ AMPKa1_Hsap --NP-V------------------------------------------------------ T01C8.1_Cele --PDAP------------------------------------------------------ Snf1_Ddis --N--------------------------------------------------------- 1110_Tthe --TPSQN-N------------------------------------------TIQISY--- 11543_Tthe --YANASKY--S----------------------------------------V------- 20428_Tthe --NPKKIQ---S----------------------------------------A---Y--- 21336_Tthe --QPLTS------------------------------------------------AA--- 26498_Tthe --NSSKE-E--S----------------------------------------V------- 4451_Tthe --SPVSG-T--HKQNMNSNVAQSFSNNSNVRGSQTIAINNNSNNNGDSSKFISPRQS--- 7432_Tthe --NPIVNL---K----------------------------------------Q------- 27742_Tthe ------------------------------------------------------------ AMPK_Spur --NP-L------------------------------------------------------ aak-1_Cele --PTPI------------------------------------------------------ CC1G_10117_Ccin HQYHHHERGRASIE------------------------------------------RARE AqueK057_Aque --KSAD------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe --SPAPCSR--E--------------------------------------------AV-- AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe --SPAPCSR--E--------------------------------------------AV-- AMPK_b-1_Smoe --FAPPSKA--PCS------------------------------------------LP-- AMPK_b-2_Smoe --FAPPSKA--PCS------------------------------------------LP-- AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam --N-PA------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer -----------------------------NT--NE------------------------- AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe ------------------------------------------------------------ 11543_Tthe ------------------------------------------------------------ 20428_Tthe ------------------------------NNHLETIKSESSSNLSTNYTNNGNLNNSHH 21336_Tthe ------------------------------------------------------------ 26498_Tthe ------------------------------------------------------------ 4451_Tthe ------------------------------------------------------------ 7432_Tthe ------------------------------KNSQQ------------------------- 27742_Tthe ------------------------------------------------------------ AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin YDG----------DGGVDLKAAAGIYCVETR--CR------------------------- AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe --GSPMVPGSPIHDNG---L-EKLVEQQQQQ--HK------------------------- AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe --GSPMVPGSPIHDNG---L-EKLVEQQQQQ--HK------------------------- AMPK_b-1_Smoe --GSPMI-SEPLHERI---AVAAATAAADIV--EQ------------------------- AMPK_b-2_Smoe --GSPMI-SEPLHERI---AVAAATAAADIV--EQ------------------------- AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel -----------------------T--GKFSKMSLQLY----QVDA----KSY-------- AMPKa2_Mmus -----------------------T--GNYVKMSLQLY----LVDS----RSY-------- AMPKa1_Mmus -----------------------T--STFSKMSLQLY----QVDS----RTY-------- SNF1_Scer ----------------------KI--PDLMKMVIQLF----QIET----NNY-------- AMPKa2_Hsap -----------------------T--GNYVKMSLQLY----LVDN----RSY-------- AMPKa1_Hsap -----------------------T--STYSKMSLQLY----QVDS----RTY-------- T01C8.1_Cele -----------------------A--ADPPKMSLQLY----QVDQ----RSY-------- Snf1_Ddis --------------------------GKPIKLVLQLF----RVAE----NRY-------- 1110_Tthe -----------------------------LNETL-----------------K-------- 11543_Tthe ------------------------------GDEYEFY----QIQK----QNV-------- 20428_Tthe HHHSYNNHYHHVNPQNQNFTGFQS--GSNVSMTNNFQ----HTQT----NSY-------- 21336_Tthe -----------------------------QNNSL-------------------------- 26498_Tthe ------------------------------TTQLQLQ----IIQQ----SENPQQINQIS 4451_Tthe -----------------------------MDGAL-----------------K-------- 7432_Tthe ----------------------NT--SQSQSQSLLNQ----QKDN----LLY-------- 27742_Tthe ------------------------------------------------------------ AMPK_Spur -----------------------T--GAQIKLGLQLY----QVDS----KSY-------- aak-1_Cele -----------------------N--PDPVKVSLQLF----ALDKKENNKGY-------- CC1G_10117_Ccin ----------------------VQ--DVVVLMNLQLY----MVDS----INY-------- AqueK057_Aque -----------------------E--SSVVKLDLQLY----QLDQ----RNF-------- AMPK_f_Smoe -------------------------------------------------VSF-------- AMPK_e_Smoe ----------------------IG--SSLVKFELQ-------VRE----EKY-------- AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ----------------------IG--SSLVKFELQLY----KVRE----EKY-------- AMPK_b-1_Smoe ----------------------GR--RNLVKFEVQLY----KMHE----EKY-------- AMPK_b-2_Smoe ----------------------GR--RNLVKFELQLY----KMHE----EKY-------- AMPK_c_Smoe -------------------------------------------------VSF-------- GK014_Glam -----------------------SAIQNDLIIGLTLYIAIDQSNH----ANY-------- GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel -----------------LLDFKSLT-NDEV------------------------------ AMPKa2_Mmus -----------------LLDFKSID-DEVV------------------------------ AMPKa1_Mmus -----------------LLDFRSID-DEIT------------------------------ SNF1_Scer -----------------LVDFKFDG-WESS------------------------------ AMPKa2_Hsap -----------------LLDFKSID-DEVV------------------------------ AMPKa1_Hsap -----------------LLDFRSID-DEIT------------------------------ T01C8.1_Cele -----------------LLDFKSLA-DEES------------------------------ Snf1_Ddis -----------------LLDIKKIE-GE-------------------------------- 1110_Tthe ----------------------SVD--NSILNKI-------------------------- 11543_Tthe -----------------YLNFKLKR-EDKLIMVNSVQTNSNY-NKSGLYQNSKKT--VQD 20428_Tthe -----------------LMPPQGNQFNNQMS----------------------------- 21336_Tthe ------------------------------------------------------------ 26498_Tthe NTNQSKIIVKIHQKTKSETGF-----SRKLMNINGINQKENVNNESEEISNM-KSPQLKS 4451_Tthe -----------------LLSNKQRD--ENVRQSANQSLTATNTPNSMNKKLKNNLNTLSV 7432_Tthe -----------------YPDFAQNI-NKKSNK---------------------------- 27742_Tthe ------------------------------------------------------------ AMPK_Spur -----------------LLDFKSLT-NPRD------------------------------ aak-1_Cele -----------------LLDFKGLT-EDEE------------------------------ CC1G_10117_Ccin -----------------LVDFHHKK-TYKA------------------------------ AqueK057_Aque -----------------LLDFKGVD-PSEE------------------------------ AMPK_f_Smoe -----------------LAVFT-------------------------------------- AMPK_e_Smoe -----------------LLDLQKLE-GP-------------------------------- AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe -----------------LLDLQKLE-GP-------------------------------- AMPK_b-1_Smoe -----------------LLDLQKLE-GP-------------------------------- AMPK_b-2_Smoe -----------------LLDLQKLE-GP-------------------------------- AMPK_c_Smoe -----------------LGAFT-------------------------------------- GK014_Glam -----------------VVDLRMIT-GE-------------------------------- GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe ---PQ------------------------------------------------------- 11543_Tthe SALNTTQDSPKNKQSQNAN-------------------------------NLSMLLQRNY 20428_Tthe ------------------------------------------------------------ 21336_Tthe ------------------------------------------------------------ 26498_Tthe SVAASSAHSQVNSQIKNTNEKIANLIRSANQKGGINAFQKDVSAQSQYKQYLP-VFFNNQ 4451_Tthe TTSSS------------------------------------------------------- 7432_Tthe ------------------------------------------------------------ 27742_Tthe ------------------------------------------------------------ AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ----H------------------------------------------------------- SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe ------YADSSF---------------------------------------------NNS 11543_Tthe QFPI----NVGNKNVVNSNNNS-------------QNNFSKTRYLSVQRQQQISKPQNAT 20428_Tthe ------------------------------------------------------------ 21336_Tthe ------------------------------------------------------------ 26498_Tthe QYSSSLNAPNTSNSIINNTINSSNINNNTIETEKQQQNQSSNNYYSKQ--------TLKT 4451_Tthe ------KQPS-A---------------------------------------------KQS 7432_Tthe --------------LQLIF----------------------------------------- 27742_Tthe ------------------------------------------------------------ AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ------KTEK-L---------------------------------------------VDT SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe PRA-------------------------------------------NGKDPMEKLRNKIK 11543_Tthe PTLEEKKNFRI---------------------SSYSIHMRGNSTQYN------------- 20428_Tthe ------------------------------------------------------------ 21336_Tthe ---------------------------------------------------------QTQ 26498_Tthe PCITEPTYHETNSIRQKLKIISQRNSTQGTSAQAFKVRIRKS------------------ 4451_Tthe PSP--------------------------------------------------------- 7432_Tthe ------------------------------------------------------------ 27742_Tthe ------------------------------------------------------------ AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam PTV-------------------------------------------K------------- SNF1A_Dmel -----------------------------------------E------------------ AMPKa2_Mmus -----------------------------------------E------------------ AMPKa1_Mmus -----------------------------------------E------------------ SNF1_Scer -----------------------------------------Y------------------ AMPKa2_Hsap -----------------------------------------E------------------ AMPKa1_Hsap -----------------------------------------E------------------ T01C8.1_Cele -----------------------------------------G------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe ETNQKRSIKNGSNNGINSSGNQNDCSFINNS--------------------------NES 11543_Tthe ---TRNSNDNVLNLSL---------------------------NQAATQNQS-KRASINS 20428_Tthe -----------------------------------------NV----------------- 21336_Tthe QTP--------------------------------------------------------- 26498_Tthe ----ATPELNNINSSINNN-----------S------------NQSNIQNTLFVNGSHNL 4451_Tthe -----------------------------------------------------------K 7432_Tthe ----------------------------NNSSNKSESNEKKQIN-----NIYFHH----- 27742_Tthe ------------------------------------------------------------ AMPK_Spur -----------------------------------------S------------------ aak-1_Cele -----------------------------------------A------------------ CC1G_10117_Ccin -----------------------------------------S------------------ AqueK057_Aque -----------------------------------------K------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe SRQQFNIPGTLGQRMRFANIKKNPNNMNANFT--NNQNMQSGH-------PQ-------- 11543_Tthe IKQQQPIPL-----------QEKLININLNFQGTNNTNT-------------KRLRKKII 20428_Tthe ------------------------------------------------------------ 21336_Tthe ------------------------------------------------------------ 26498_Tthe VSQQQ-----------------KRSNSNNNI--TNNQNSATGNSSNLQTSPEKKFKTKQI 4451_Tthe ------------------------------------------------------------ 7432_Tthe ------------------------------------------------------------ 27742_Tthe ------------------------------------------------------------ AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe ----------------------STLPSRGY---SQGRESKSHAS---QRQKQQQTGNKVR 11543_Tthe S-----------------MHDTSYNP---------------------------------- 20428_Tthe ------------------------------------------------------------ 21336_Tthe --------------------------TSQFSQNHWANRTRIHMRHISQAGK------RP- 26498_Tthe SRSSRRFVSAERENNQMIQQSLVDDP---------------------------------- 4451_Tthe --------------------------------------SKSKLQ---QQQQQMQQQNSMH 7432_Tthe ------------------------------------------------------------ 27742_Tthe ------------------------------------------------------------ AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam --------------------------------------TS-------------------- SNF1A_Dmel ---------------------------------QG------------------------- AMPKa2_Mmus ---------------------------------QR------------------------- AMPKa1_Mmus ---------------------------------AK------------------------- SNF1_Scer ---------------------------------GD------------------------- AMPKa2_Hsap ---------------------------------QR------------------------- AMPKa1_Hsap ---------------------------------AK------------------------- T01C8.1_Cele ---------------------------------SA------------------------- Snf1_Ddis ------------------------------------------------------------ 1110_Tthe GVTQERKG-V-S-----------------PIERERGKSTEPF------------------ 11543_Tthe ------------------------------------------------------------ 20428_Tthe ------------------------------------------------------------ 21336_Tthe -------GSIQQ-----------------AYEKERGKSTEPQID---------------- 26498_Tthe ------------------------------------------------------------ 4451_Tthe --------SSVNNHSNGYHSTLPSHNIKLTNKSQSSGTSNNNNQNSLQNSQLGQSKLVNN 7432_Tthe ------------------------------------------------------------ 27742_Tthe ------------------------------------------------------------ AMPK_Spur ---------------------------------GM------------------------- aak-1_Cele ---------------------------------V-------------------------- CC1G_10117_Ccin ---------------------------------TE------------------------- AqueK057_Aque ---------------------------------TE------------------------- AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam -------------------------------------SEAPEMT---------------- SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe --------------------DDCNTSGYRILGIDNCNTSLNTS----------------- 11543_Tthe ------------------------------------------TKQNSFNAGKMNKENSVA 20428_Tthe -------------------------------SN--------------------------- 21336_Tthe --------------------DSANTSGYKILNASILDQSLNGSLNNTFVLNQT------- 26498_Tthe ------------------------------------------TKNKFFRQ---------- 4451_Tthe TQTQQQNKPVSQSSSINSTQNAISVSNTQ------------------------------- 7432_Tthe -------------------------------QSNNCSSHIQAS----------------- 27742_Tthe ------------------------------------------------------------ AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam --------------------VEYDDGGLRICKDDIT------------------------ SNF1A_Dmel ------------------------------------DDV--------------------- AMPKa2_Mmus ------------------------------------SGSSTPQRSCSAA----------- AMPKa1_Mmus ------------------------------------SGTATPQRSGSIS----------- SNF1_Scer ------------------------------------D----------------------- AMPKa2_Hsap ------------------------------------SGSSTPQRSCSAA----------- AMPKa1_Hsap ------------------------------------SGTATPQRSGSVS----------- T01C8.1_Cele ------------------------------------SASS--SRHASMS----------- Snf1_Ddis ------------------------------------------------------------ 1110_Tthe --------------------GFHNNITINNP----T------------------------ 11543_Tthe SNSGSKQEIRIFNNMEFLSYGSVNN-NLNNH----S------------------------ 20428_Tthe ---------------------DFGQN-MESQSQSYAIGSNFNNMNYS--QSGYQF----D 21336_Tthe --------------------AFINGHNINNG----G------------------------ 26498_Tthe ----------------------------GSSSIQKN------------------------ 4451_Tthe -----------------------QSIS--------------------------------- 7432_Tthe --------------------NLYQS--IQTKQIQL-NSS--STKACSSSHQLFQSEKKQN 27742_Tthe ---------------------FHSNN-TNNH----I------------------------ AMPK_Spur ------------------------------------T----------------------- aak-1_Cele ------------------------------------PPSRCRSRAASVS----------- CC1G_10117_Ccin ------------------------------------PGAGKFD----MA----------- AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ---------------------------KEN------------------------------ SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ----------------------------------------GLHRAR---SSFD------- AMPKa1_Mmus ----------------------------------------NYRSCQ---RSDS------- SNF1_Scer ---------------------------------------------------TT------- AMPKa2_Hsap ----------------------------------------GLHRPR---SSFD------- AMPKa1_Hsap ----------------------------------------NYRSCQ---RSDS------- T01C8.1_Cele ----------------------------------------MPQKPAGIRGTRT------- Snf1_Ddis ------------------------------------------------------------ 1110_Tthe --L---------G--------------------L-------------------------- 11543_Tthe --LELEI---------------------------------------------------EN 20428_Tthe SGM---------N--------------------LNNGNTQNPNNSQ---NNALD------ 21336_Tthe --V---------GNKVQKANFNILQGITGFRTTA-------------------------- 26498_Tthe --IQNYLNIIEKNSASNMNNIHNTDKQNINVVIK-------------------KPENIDN 4451_Tthe --------------------------MSNNNTSS-------------------QQGYSQN 7432_Tthe QNI---------N--------------------KKKNQISNISKTQ---SSSS------- 27742_Tthe --I---------G--------------------N-------------------------- AMPK_Spur ----------------------------------------NFGS-------DD------- aak-1_Cele ----------------------------------------VTLAKS---KSDL------- CC1G_10117_Ccin ----------------------------------------HFEIPSD---SCS------- AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe N----------------------------------------------------------- 11543_Tthe NQKNLQQNYQTC--------------------------NGTRGNKIDVNNSLVLPKG--- 20428_Tthe ------------------------------------------------------------ 21336_Tthe N-S-GAQ----------------------------------------------------- 26498_Tthe NGQSFQSEMKKQ--------------------------DQTNNQTPSINKEVK------- 4451_Tthe NINSNNQQKNSKNNDISENLATEPNYTSKHVQQSSQSSNGQYQNSSNINNGQIKNHSLSI 7432_Tthe ------------------------------------------------------------ 27742_Tthe NNNNNNQNYNNS------------------------------------------------ AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus ------------------------------------------------------------ AMPKa1_Mmus ------------------------------------------------------------ SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ------------------------------------------------------------ AMPKa1_Hsap ------------------------------------------------------------ T01C8.1_Cele ------------------------------------------------------------ Snf1_Ddis ------------------------------------------------------------ 1110_Tthe ------------------------------------------------------------ 11543_Tthe ------IPRVHTDENDKNN----------------------------------------- 20428_Tthe ------------------------------------------------------------ 21336_Tthe ------------------------------------------------------------ 26498_Tthe ------EPKIRVISESPMCK---------------------------------------- 4451_Tthe SKQNAVSPRI---------ATENSDPYYRQHIYQNNSNSSSSKSYMNSSKISPSTTTNAS 7432_Tthe ------------------------------------------------------------ 27742_Tthe ------------------------------------------------------------ AMPK_Spur ------------------------------------------------------------ aak-1_Cele ------------------------------------------------------------ CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel ------------------------------------------------------------ AMPKa2_Mmus -------------------------------------------------SSTAEN----- AMPKa1_Mmus -------------------------------------------------DAEAQG----- SNF1_Scer -------------------------------------------------V---------- AMPKa2_Hsap -------------------------------------------------STTAES----- AMPKa1_Hsap -------------------------------------------------DAEAQG----- T01C8.1_Cele -------------------------------------------------SSMPQA----- Snf1_Ddis ------------------------------------------------------------ 1110_Tthe ------------------------------------------------------------ 11543_Tthe ------------------------------------------------------------ 20428_Tthe --------------------------------------------------TNNIP----- 21336_Tthe ------------------------------------------------------------ 26498_Tthe ------------------------------------------------------------ 4451_Tthe YQNKHLTVQSGIKVHRGPFNLRAITNKDPKYIVSELIKTLESFKMYYKPTSKFDI----- 7432_Tthe ----------------------------------------------------QLI----- 27742_Tthe ------------------------------------------------------------ AMPK_Spur -------------------------------------------------RMEVEE----- aak-1_Cele -------------------------------------------------NGNSSKVPMSP CC1G_10117_Ccin -------------------------------------------------ESERSV----- AqueK057_Aque ------------------------------------------------------------ AMPK_f_Smoe --------------------------------------------------RYVSI----- AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe --------------------------------------------------RYISI----- GK014_Glam ------------------------------------------------------------ GK013_Glam --------------------------------LENI------------------L----- GK015_Glam ---------------------GVVTTVQYEDLVVRLKQVFKELRIKADSEREGSF----- SNF1A_Dmel ------------------------------IME---------SL--T---PPP-LS-VS- AMPKa2_Mmus ----------------------HS--LSGSLTG---------SL--T---G---ST-LS- AMPKa1_Mmus ----------------------KP--SDVSLTS---------SV--T---SLD-SS-PV- SNF1_Scer --------------------------------S---------NI--------------S- AMPKa2_Hsap ----------------------HS--LSGSLTG---------SL--T---G---ST-LS- AMPKa1_Hsap ----------------------KS--SEVSLTS---------SV--T---SLD-SS-PV- T01C8.1_Cele ----------------------MS--MEASIEK--------MEV--H---DFS-DM-SC- Snf1_Ddis ------------------------------------------------------------ 1110_Tthe --------------------------------S-----------SLKN-NTTNS------ 11543_Tthe ------------------------------------------------------------ 20428_Tthe ----------------------KF--SKQDLVF---------TI--QI-YQMPSTS---- 21336_Tthe ---------------------------NNYLNA-----------SLNT-S-IDN------ 26498_Tthe -----------------------------------------------KDQHSNE------ 4451_Tthe ----------------------RV--EKDLVKF---------DISVNI-LHNVE------ 7432_Tthe ----------------------EQQQFQNQEQL---------AQ--NL-IQMTSSQYANP 27742_Tthe ---------------------------NNIYNN-----------ILQN-DYSSQ------ AMPK_Spur ----------------------PM--SPRSPT-----------T--P---TLP----QS- aak-1_Cele LSPMSPISPSVNIPKVRVDDADAS--LKSSLNSSIYMADIENSM--E---SLDEVS-TQ- CC1G_10117_Ccin ----------------------KE--KEGC--F---------GI--------------G- AqueK057_Aque ----------------------------VSI--------------------------LG- AMPK_f_Smoe ----------------------V-----------------------------------C- AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ----------------------L-----------------------------------C- GK014_Glam ------------------------------------------------------------ GK013_Glam ----------------------KI--QRED---------------------TQS------ GK015_Glam ----------------------KC--ERMNVQF---------SI--DI-YRIGSA--IS- SNF1A_Dmel --------------------------------------------G--------------- AMPKa2_Mmus --------------------------------------------S--------------- AMPKa1_Mmus --------------------------------------------D--------------- SNF1_Scer --------------------------------------------E--------------- AMPKa2_Hsap --------------------------------------------S--------------- AMPKa1_Hsap --------------------------------------------D--------------- T01C8.1_Cele --------------------------------------------D--------------- Snf1_Ddis ------------------------------------------------------------ 1110_Tthe ---------------------------------------NNYSFDLGNYAQLQLSQQQQI 11543_Tthe ------------------------------------------------------------ 20428_Tthe ------------------------------------IQSDQHIVDV-------------- 21336_Tthe ---------------------------------------RNNQIGF--------IQQNGN 26498_Tthe ---------------------------------------SKYYLGLKQ--QM-I------ 4451_Tthe ---------------------------------------NLFIIKF-------------- 7432_Tthe EIASKSYSFQKLNILNHTNSTCEDGSVMVIQPNEQLMNSQKYNEDI-------------- 27742_Tthe ---------------------------------------NPYLQQN-------------- AMPK_Spur --------------------------------------------P--------------- aak-1_Cele --------------------------------------------S--------------- CC1G_10117_Ccin --------------------------------------------G--------------- AqueK057_Aque --------------------------------------------G--------------- AMPK_f_Smoe --------------------------------------------S--------------- AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe --------------------------------------------S--------------- GK014_Glam ------------------------------------------------------------ GK013_Glam ---------------------------------------DRSLNDL-------------- GK015_Glam ---------------------------------------PQLGILM-------------- SNF1A_Dmel -----------------------------------VM----------------------- AMPKa2_Mmus -----------------------------------AS----------------------- AMPKa1_Mmus -----------------------------------VA----------------------- SNF1_Scer -----------------------------------D------------------------ AMPKa2_Hsap -----------------------------------VS----------------------- AMPKa1_Hsap -----------------------------------LT----------------------- T01C8.1_Cele -----------------------------------VTPPPS------------------- Snf1_Ddis ------------------------------------------------------------ 1110_Tthe QITQQL-----------------NSSFQH-------------N-GY-------------- 11543_Tthe ----------------------------Q-------------NKNGNNQN---------- 20428_Tthe ---I---------------------------------L---------------------- 21336_Tthe FKQNNL-----------------NSTAYH-------------NFNLGNKN---------- 26498_Tthe -----Q-----------------KEPLIC-------------NFSINNDS---------- 4451_Tthe ---T-------------------------------------------------------- 7432_Tthe ---RLNTSEEKLVSVSVHKHLNLQESVKRPQTNSQVSINPNKN-G-IDQLNIIQNFEKSS 27742_Tthe ---QQL-----------------QAALLH-------------Q----------------- AMPK_Spur -----------------------------------GS----------------------- aak-1_Cele -----------------------------------SE----------------------- CC1G_10117_Ccin -----------------------------------R------------------------ AqueK057_Aque -----------------------------------GS----------------------- AMPK_f_Smoe -----------------------------------L------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe -----------------------------------L------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ---A-------------------------------------------------------- GK015_Glam ---R-------------------------------------------------------- SNF1A_Dmel ---------------------------PL------------------------------- AMPKa2_Mmus ---------------------------PR------------------------------- AMPKa1_Mmus ---------------------------PR------------------------------- SNF1_Scer ------------------------------------------------------------ AMPKa2_Hsap ---------------------------PR------------------------------- AMPKa1_Hsap ---------------------------PR------------------------------- T01C8.1_Cele ---------------------------PG------------------------------- Snf1_Ddis ------------------------------------------------------------ 1110_Tthe ----------SNS------------------NINCN----IVP----------------- 11543_Tthe --KINAI-QINNSN----------------------NSNAISQRSKK--TDQSKSENIKL 20428_Tthe ------------------------------------------------------------ 21336_Tthe --KLNNILGVQNSNRVGTAVNYDYNATPSIANTNNN----IYKKNY-------------- 26498_Tthe --NINHH-LTNNDG------------------INSTIDDIVQQKSNQKLTSWPHSQNYYL 4451_Tthe ------------------------------------------------------------ 7432_Tthe PKNNNYS-QIENSQ-----------------KTNNNSQKILSQKHL-------------- 27742_Tthe ------------------------------------------------------------ AMPK_Spur ---------------------------PR------------------------------- aak-1_Cele ---------------------------PE------------------------------- CC1G_10117_Ccin ------------------------------------------------------------ AqueK057_Aque ---------------------------PQ------------------------------- AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam ------------------------------------------------------------ GK013_Glam ------------------------------------------------------------ GK015_Glam ------------------------------------------------------------ SNF1A_Dmel --------------------------------Q-----PTG------------------- AMPKa2_Mmus --------------------------------------L-G------------------- AMPKa1_Mmus --------------------------------------P-G------------------- SNF1_Scer --------------------------------E-----MST------------------- AMPKa2_Hsap --------------------------------------L-G------------------- AMPKa1_Hsap --------------------------------------P-G------------------- T01C8.1_Cele --------------------------------G-----AKL------------------- Snf1_Ddis ------------------------------------------------------------ 1110_Tthe ---------SSIQSSNTT--------KSSSQSH-----RRG---KSSPLQNILNKLEKNK 11543_Tthe NKILPFSIQ----TNQIANNSMVAGNINNLQIQQNLNQNSQGGGSSQ------------- 20428_Tthe ---------------------------------------NK------------------- 21336_Tthe ----PQ---TTFNSNNVS--------LNSSQIQ-----------S--------------- 26498_Tthe NAPVTHSNNKSY-LNNISNSSRISSQLNEQQLQS-----LQPPT--M------------- 4451_Tthe --------------------------------------RLI------------------- 7432_Tthe ---------------------------KVLNNQ-----LQN------------------- 27742_Tthe -------------NSN-----------NSSSQQ-----RKG---SSY------------- AMPK_Spur --------------------------------------CMQ------------------- aak-1_Cele --------------------------------A-----PIR------------------- CC1G_10117_Ccin --------------------------------E-----DEV------------------- AqueK057_Aque --------------------------------L-----PQR------------------- AMPK_f_Smoe --------------------------------T-----MQA------------------- AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ------------------------------------------------------------ AMPK_b-1_Smoe ------------------------------------------------------------ AMPK_b-2_Smoe ------------------------------------------------------------ AMPK_c_Smoe --------------------------------T-----MQA------------------- GK014_Glam ------------------------------------------------------------ GK013_Glam --------------------------------------SEQ------------------- GK015_Glam --------------------------------------RIS------------------- SNF1A_Dmel -------------HHTM---------------EFFE-MC-A----ALII----------- AMPKa2_Mmus -------------SHTM---------------DFFE-MC-A----SLIT----------- AMPKa1_Mmus -------------SHTI---------------EFFE-MC-A----NLIK----------- SNF1_Scer -------------FSAY---------------PFLH-LT-T----KLIM----------- AMPKa2_Hsap -------------SHTM---------------DFFE-MC-A----SLIT----------- AMPKa1_Hsap -------------SHTI---------------EFFE-MC-A----NLIK----------- T01C8.1_Cele -------------SQTM---------------QFFE-IC-A----ALIG----------- Snf1_Ddis ---------------IF---------------IFFD-IC-S----LMLE----------- 1110_Tthe NIQQGNNNNNYNLNNSFNLNNTYNGPAAYISSNYTTKNQ-N----QQ------------- 11543_Tthe --------SS-GRVPSY---------------KFRK-V---------------------- 20428_Tthe -------------GHPI---------------MFLE-FF-N----QFLT----------- 21336_Tthe --------NNDSLNTSI---------------NFNNTMYGS----VN------------- 26498_Tthe --------EN-SRSEHL---------------KFKA-VT-N----SLIS----------- 4451_Tthe -------------GDTH---------------KYNE-IC-N----NILN----------- 7432_Tthe -------------GMSQ---------------INTQ-LF-K----KYLTLNTNESKMFPQ 27742_Tthe --------NQYRINLRINNQK----P-------Y--QKK-T----TI------------- AMPK_Spur -------------HCTM---------------EFFE-MC-A----SLIA----------- aak-1_Cele -------------SQTM---------------EFFA-TC-H----IIMQ----------- CC1G_10117_Ccin -------------VSPF---------------VFMD-VA-C----RLIL----------- AqueK057_Aque -------------HYTM---------------EFFE-AC-S----RLIC----------- AMPK_f_Smoe -------------AVTY---------------YIIL-NC-D----RQIS----------- AMPK_e_Smoe ---------------FF---------------IFLD-FC-G----SFLA----------- AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe ---------------FF---------------IFLD-FC-G----SFLA----------- AMPK_b-1_Smoe ---------------FF---------------TFLD-FC-T----MFLA----------- AMPK_b-2_Smoe ---------------FF---------------TFLD-FC-S----MFLA----------- AMPK_c_Smoe -------------AVTY---------------YIIL-NC-D----RQIS----------- GK014_Glam ---------------LN---------------LFLH-YA-QRIGQAITE----------- GK013_Glam -------------GY-------------------------------GP------------ GK015_Glam -------------GDGA---------------IYKE-IG-Q----IVF------------ SNF1A_Dmel -------------------------------------------------------Q---- AMPKa2_Mmus -------------------------------------------------------A---- AMPKa1_Mmus -------------------------------------------------------I---- SNF1_Scer -------------------------------------------------------EL-A- AMPKa2_Hsap -------------------------------------------------------T---- AMPKa1_Hsap -------------------------------------------------------I---- T01C8.1_Cele -------------------------------------------------------T---- Snf1_Ddis -------------------------------------------------------E---- 1110_Tthe ----------------------------------------------------------Y- 11543_Tthe ------------------------KPNQYEDQF---------------------NL-TA- 20428_Tthe -------------------------------------------------------LVNK- 21336_Tthe ----------------------------------------------------------P- 26498_Tthe NSYSLVNVQKYKVRKSKINSGLHNISNSIMSVN---------------------NAISN- 4451_Tthe ----------------------------YVQSS---------------------TNHES- 7432_Tthe QLPQSTKSVSGQLQQQQWQNKTQQQSPIHNNFFQEKKPKKQLTAQQKQLLINNKTQVQK- 27742_Tthe ----------------------------------------------------------L- AMPK_Spur -------------------------------------------------------T---- aak-1_Cele -------------------------------------------------------A---- CC1G_10117_Ccin -------------------------------------------------------EL-AG AqueK057_Aque -------------------------------------------------------S---- AMPK_f_Smoe ------------------------------------------------------------ AMPK_e_Smoe -------------------------------------------------------E---- AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe -------------------------------------------------------E---- AMPK_b-1_Smoe -------------------------------------------------------E---- AMPK_b-2_Smoe -------------------------------------------------------E---- AMPK_c_Smoe ------------------------------------------------------------ GK014_Glam -------------------------------------------------------H---- GK013_Glam ----------------------------------------------------------G- GK015_Glam ----------------------------------------------------------K- SNF1A_Dmel --------------------------------LAR AMPKa2_Mmus --------------------------------LAR AMPKa1_Mmus --------------------------------LAQ SNF1_Scer -----------------------------VNSQSN AMPKa2_Hsap --------------------------------LAR AMPKa1_Hsap --------------------------------LAQ T01C8.1_Cele --------------------------------LAR Snf1_Ddis --------------------------------LNL 1110_Tthe -----------------------------NRKQIY 11543_Tthe -----------------------------SNEVND 20428_Tthe -----------------------------KLNPIH 21336_Tthe -----------------------------KKRQIF 26498_Tthe -----------------------------HTKDKI 4451_Tthe -----------------------------SSQVFR 7432_Tthe -----------------------------RFLFDQ 27742_Tthe -----------------------------PIQQKK AMPK_Spur --------------------------------LAR aak-1_Cele -------------------------------LLAE CC1G_10117_Ccin GGELVEGRGRGVVTEEVGCGGSRREKETGLRGDAM AqueK057_Aque --------------------------------LAQ AMPK_f_Smoe -------------------------------AGFA AMPK_e_Smoe -------------------------------LRVL AMPK_a_Smoe -------------------------------FWKH AMPK_d_Smoe -------------------------------LRVL AMPK_b-1_Smoe -------------------------------LRVL AMPK_b-2_Smoe -------------------------------LRVL AMPK_c_Smoe -------------------------------AGFA GK014_Glam -------------------------------FRAG GK013_Glam -----------------------------RSRLQK GK015_Glam -----------------------------GLKLKG