CLUSTAL W (1.83) multiple sequence alignment BIKE_Hsap MKKFSRMPKSE---GGSGGGAAGGG---AGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLE AAK1_Hsap MKKFFDSRREQ---GGSGLGS--GS---SGGGG--STSGLGSGYIG-RVFGIGRQQVTVD BIKE_Mmus MKKFSRMPKSE---GSGGG-AAAGG---AAGGG--LGGGFASSSMGVRVFAVGRYQVTLE AAK1_Mmus MKKFFDSRREQ---GSSGLGS--GS---SGGGG--SSSGLGSGYIG-RVFGIGRQQVTVD sel-5_Cele MPLGLFSSGKA--QVLCD-EKIP-----GGKKK-EPKQLSENKCKG-VTLKLDHTRVTIE DDB0229347_Ddis MNRFLEFSNNFLEVAGNTINNISSKSITDNVGN--VWGNITGGRVG-QVYDINGRRVTEV DDB0229350_Ddis MG----------------------------------------NNQG-KTLKIGSYHLNFV Nak_Dmel MKKILSKFERN---ENSRLEN--PP---NSSSS--SSSNEKNSFVG-KVFTVGRVTVTVE AKL1_Scer MSITNGTSRSV---SAM------------------GHPAVERYTPG-HIVCVGTHKVEVV ARK1_Scer MNQP----------------------------------QIGTYNVG-TQLTVGSHQVEII PRK1_Scer MNTP----------------------------------QISLYEPG-TILTVGSHHAKII AAK1_Spur MV---------------------------------------------------------- AqueK170_Aque MAELVRKRS-S---G---------------------RQRLRQGYVG-KTFTLDGRQYIVE * BIKE_Hsap ESLAEGGFSTVFLVRTH---------------GGIRCALKRMYVN-NMPDLNVCKREITI AAK1_Hsap EVLAEGGFAIVFLVRTS---------------NGMKCALKRMFVN-NEHDLQVCKREIQI BIKE_Mmus ESLAEGGFSTVFLVRTH---------------SGIRCALKRMYVN-NTPDLNICKREITI AAK1_Mmus EVLAEGGFALVFLVRTS---------------NGVKCALKRMFVN-NEHDLQVCKREIQI sel-5_Cele KQIAEGGFAIVYVASDRK---------------NNKFALKRQFTKDNEKQLEACCREHSF DDB0229347_Ddis KLVAEGGFGFVYLVRDDY--------------N-NMYALKRMFIQ-ERERLEAMKNEIDV DDB0229350_Ddis KQIAEGGFSYVFLVKDSN--------------TSKHYALKRILIR-DEDELKGVKHEISI Nak_Dmel DVLAEGGFAMVFLARGNGGG----------SSSATKYALKRMYVN-NEHDLNVAKREIQI AKL1_Scer NYLAEGGFAQIYVVKFLEYLNEFDNTASVPLKIGDVACLKRVLVQ-DENGLNEMRNEVEV ARK1_Scer KYLTSGGFAQVYSALINPPD---------PHSNSSVACLKRVIVP-DKPSLNTLRAEVDA PRK1_Scer KYLTSGGFAQVYTAEISPPD---------PYSNANIACLKRVIVP-HKQGLNTLRAEVDA AAK1_Spur ------------------------------------------------------------ AqueK170_Aque DVIAEGGYAIVLEVKCTA-------------GTNERLALKRVAVN-SEQDLYLCRQEIAI BIKE_Hsap MKELSGHKNIVGYLDCAVNSI-SD--NVWEVLILMEYCRAGQVVNQMNKKLQ--TGFTEP AAK1_Hsap MRDLSGHKNIVGYIDSSINNV-SSG-DVWEVLILMDFCRGGQVVNLMNQRLQ--TGFTEN BIKE_Mmus MKELSGHKNIVGYLDCAVNSI-SD--NVWEVLILMEYCRAGQVVNQMNKKLQ--TGFTES AAK1_Mmus MRDLSGHKNIVGYIDSSINNV-SSG-DVWEVLILMDFCRGGQVVNLMNQRLQ--TGFTEN sel-5_Cele LKQCIGHKNIVEFVDSYTNCL-GN--GIWECMLLTEYHQ-KNVLQLMNERISQNQYLTND DDB0229347_Ddis MQKLRNNPNIVKLEGFKINEN-RNT-RETEVLMLMEYCSGGSVLDIMNARGEF-TRLEER DDB0229350_Ddis MKRLTKHKNIVKILDYHKVS---DK-NNTEMFILMEYCSGGHLVEIMQKRLSSGSKFTDQ Nak_Dmel ASNLSGHKNIIGYVDSSITPT-GN--GVCEVLLLMPYCKH-HMLAMMNARLH--VGFTEP AKL1_Scer MKKLKGAPNIVQYFDSNASRR-RDGVQGFEVLLLMELCPNKSLLDYMNQRLS--TKLTEA ARK1_Scer MRLLKNNRYVVSYIDSHAAKAMLHN-GSYEVFVLMEYCERGGLIDFMNTRLQ--NRLHEF PRK1_Scer MKLLRNNKHVVSYIDSHAARS-VNG-IAYEVFVLMEFCERGGLIDFMNTRLQ--NRLQES AAK1_Spur --------------------------------------TDGHVVQQMNERLS--VGFTEQ AqueK170_Aque LKALSDSPNSVTYLASQINKL-SR--EVYEVLILMQLYGGQTGLQLIRQYHGQGKRLPEA : :. : : BIKE_Hsap EVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLND--GGNYVLCDFGSATNKFLNPQ- AAK1_Hsap EVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHD--RGHYVLCDFGSATNKFQNPQ- BIKE_Mmus EVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLND--AGNYVLCDFGSATNKFLNPQ- AAK1_Mmus EVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHD--RGHYVLCDFGSATNKFQNPQ- sel-5_Cele EILSIFTDLCEAVSFIHNRPQPIIHRDLKVENVLISSHKPPHYVLCDFGSATTQILSVE- DDB0229347_Ddis EILAIFSDVCNGVLAMHQQQPPIAHRDLKIENVLYCE-HSNRYKLCDFGSSTIKTFNT-A DDB0229350_Ddis EILKIFQDICESVAYMHSQQPLIIHRDLKVENVLLDE-ESGIYKLCDFGSATEEITRMKN Nak_Dmel EVLNIFCDIAEAVSRLHYCQTPIIHRDLKVENILQTD--AGNFVLCDFGSATAKTLNPQ- AKL1_Scer EIVKIMYDVALSISQMHYLPVSLIHRDIKIENVLVDA--KNNFKLADFGSTSTCFPIVTT ARK1_Scer EILQIMSQVTQGVAAMHALQPPLIHRDIKIENVLISA--NNEYKLCDFGSVCGIIRPPRN PRK1_Scer EILEIMSQTVQGITAMHALQPPLIHRDIKIENVLISH--DGLYKVCDFGSVSGVIRPPRN AAK1_Spur EVLRIFCNVCEAVSRLHHCQTPIIHRDLKVENILLHR--SGNYMLCDFGSATGRVLDPK- AqueK170_Aque LILKIFTDVCLAVSRLHHRTKPIIHRDLKVTLLQM---------------------DPK- :: *: : .: :* : ***:*: : BIKE_Hsap KDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGES- AAK1_Hsap TEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGES- BIKE_Mmus KDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGES- AAK1_Mmus AEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGES- sel-5_Cele KYGVEYVKSEVERNTTMCYRSPEMIDFYSGLEIGLKSDIWALGVLLYRLCFFCVPFEES- DDB0229347_Ddis T-ERGKAEDDINMFTTLFYRAPEMVDLYRGQIIDEKVDVWALGCLLFKMAFYVDPFDGG- DDB0229350_Ddis KTEMQNAEDDISRHTTLQYRAPEIVDFYRSPVINEKIDIWALGCLLYKLLFYVTPFEDSG Nak_Dmel QHGVTVVQEEIQKYTTLSYRAPEMIDLYGGKSITTKADIWALGCMLYKLCFFSLPFGES- AKL1_Scer HQDIALLTQNIYVHTTPQYRSPEMIDLYRCLPINEKSDIWALGVFLYKLLFFTTPFEMTG ARK1_Scer SQELSYVQQDILKNTTAQYRSPEMIDTFRGLPIDEKSDIWALGIFLYKLCYYTTPFEKGG PRK1_Scer TQEFNYVQHDILTNTTAQYRSPEMIDLYRGLPIDEKSDIWALGVFLYKICYYTTPFEKSG AAK1_Spur VHSINDIKDEIEKYTTVSYRSPEMIDLYSEKTITTKADIWALGCMLYKLCFFTLPFGES- AqueK170_Aque EVGVGECQDQLQKFTTLAYRAPEMVDLYSGYTISTKSDIWALGCLLYKFCFFDTPFGEQ- :: ** **:**::: : * * *:**** :*::: :: ** BIKE_Hsap QVAICDGNFTIPD-NSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFAFKFAKKDCPVSNI AAK1_Hsap QVAICDGNFTIPD-NSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNV BIKE_Mmus QVAICDGSFTIPD-NSRYSHNVHCLIRFMLEPDPECRPDIFQVSYFAFKFAKKDCPVSNI AAK1_Mmus QVAICDGSFTIPD-NSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPVPNV sel-5_Cele PLAIQSVNYQFPS-VPNIPDEIKVLIYMLLDIDVNRRPSIYQTSVLAFEANHRKPLSEEI DDB0229347_Ddis SLQIINNNYKIPD-NSKYSNNFHKLIQFILVADPTQRPSINDLLNYLNEIRGSSRRGL-- DDB0229350_Ddis SLGILNSNYTIPP-NHTHSNDLISLIKIMLNPDPINRPNIFEITNQLNLLRNQ-QPLFPS Nak_Dmel TLAIQNGQFSIPD-SSKYSKGMHQLIKYMLEPDMEKRPNIWQVCEVAFRLAGKDNPVQNL AKL1_Scer QFAILHSKYEFPV-N-KYSSKLINLIIIMLAENPNLRPNIYQVLYHLCEILNVEVPIEDK ARK1_Scer DLAILSGKFEFPL-YPNYSEQLKGLIRDILVQDPRHRPNVYQLLKRISIMQNVPCPINDI PRK1_Scer EAGILHARYQYPS-FPQYSDRLKNLIRLMLMEAPSQRPNICQVLEEVSRLQNKPCPIRNF AAK1_Spur SLAIQSGNFTIPD-NTKYSREMHALIRYMLEVDAEKRPDIFQVSHVAFKAASSETPIQNL AqueK170_Aque TLAIMRGTFSFPADASNYSNGLLGLIKYTLNTDPNKRPDIFQVSWVAYKLAGKDCPIVNV * : * . . ** * **.: : BIKE_Hsap NNS------------------------------------------------------SIP AAK1_Hsap QNS------------------------------------------------------PIP BIKE_Mmus NNS------------------------------------------------------FLP AAK1_Mmus QNS------------------------------------------------------PIP sel-5_Cele QNKKCTDAV---------PSLKSCIQLMRDGSNP---RNKRDSSPRN------------- DDB0229347_Ddis ---QT--------------------FSSNNNNSN----NNSNNNSNNNSNNNSVNNSSNS DDB0229350_Ddis HKSNI--------------------LLSYNENNN---INNNNNNINNNNNNNIVNGKNIP Nak_Dmel HKT------------------------------------------------------PIP AKL1_Scer YAEGAYNFSKYTQFQNKLQNVQ--LQMYQLQQKKIMQNNKLSDSEENLLNDMFLSSFEIS ARK1_Scer QVV------------------------------------------------------QAP PRK1_Scer YLL------------------------------------------------------RAM AAK1_Spur HKS------------------------------------------------------PVP AqueK170_Aque FNS------------------------------------------------------PIP BIKE_Hsap SAL--PEPMTASEAA-ARKSQI-KARITD---TI--GPTE-TSI------------APRQ AAK1_Hsap AKL--PEPVKASEAA-AKKTQP-KARLTD---PI--PTTE-TSI------------APRQ BIKE_Mmus STL--PEPMTATEAA-ARKSQM-KARITD---TI--GPTE-TSI------------APRQ AAK1_Mmus AKL--PEPVKASEAA-VKKTQP-KARLTD---PI--PTTE-TSI------------APRQ sel-5_Cele -PE--APPIQSSSKM-ASLSQQ-VPSISNISMPSGSGTVE-TSV------------APRL DDB0229347_Ddis IN--RPIRTSS---------------------------------------------SSNS DDB0229350_Ddis KP--LPKVVSQTTPT--------------------P--TP-PPP------------APSQ Nak_Dmel NFDLLVVPPFESEAKRISAAAS-KAAKAQ-NVSV--VEAG-TSV------------APRS AKL1_Scer S--KLPMNA--SDGH-AAVSRIPSQNVGQE-L----EEEK-ESQSDQRKSTLSEDKSSRT ARK1_Scer SSH--LNLTELHQLS-A-------TQ------NI--L---SLNS------------P--- PRK1_Scer NQN--ANTQLAGEPS-STTYV-PTQK----FIPV--QSLQSINQ------------PPNM AAK1_Spur DGNKLPLPLTESEQR-QQHSRS-KTNNQN-RTPAGPMEVS-TSV------------TPRQ AqueK170_Aque SVL--DMPMQLVKPK-ATKTLS-VSETTD-SNST-------------------------- BIKE_Hsap RPKA-NS-AT-------------TATP-SVLTIQSSATPVKVLA-P----GEFGN---HR AAK1_Hsap RPKA-GQ-T--------------QPNP-GILPIQPALTPRKRAT-VQPPPQAAGS---SN BIKE_Mmus RPKA-NS-T--------------AATS-SVLTIQSSATPVKVPA-P----GEFSN---HK AAK1_Mmus RPKA-GQ-T--------------QPNP-GILPIQPALTPRKRAT-VQPLPQAAGP---SN sel-5_Cele RPKA-TT-V--------------VPNVPSISPVPPVGLPHLRLPSKGSTDETDGS---QV DDB0229347_Ddis TPNF-N-SPNTNNNNYNNNNNNS--KN-YGN--TPNST---------------------- DDB0229350_Ddis SPSP-SPSPTVVNNIENNSNGLEHSNS-NGNISQPSPTPPKRRATPGTTPS-LQP---VS Nak_Dmel RPKG-SS-SVH------------GGNP-LGLGLPPSPSPRQNITSPQPQPQPVVEQFQAN AKL1_Scer TSNA-NS-SGT------------ANNPQEINTIQSPGIEDK----------SIFE---NK ARK1_Scer --TTMEN-T--------------MPN--ATFQISMADNTTTA-Q-M-------------- PRK1_Scer MPVTHVS-T--------------TPNL-GTFPISINDNNKTEVT-AHAGLQVGSH---SN AAK1_Spur RPKA-SQ-QGV------------APAAGGISLPTPSSITRQRSS-KQGQPPTTGP---TV AqueK170_Aque ---------P-------------TPSP-SVM---------KRTTS-Q-QPT--------- BIKE_Hsap PK---------------------------------------------------------- AAK1_Hsap QP---------------------------------------------------------- BIKE_Mmus PK---------------------------------------------------------- AAK1_Mmus QP---------------------------------------------------------- sel-5_Cele R----------------------------------------------------------- DDB0229347_Ddis -PPNAKKNIFDILGDDT-TSSTSNSNNSPSVSRNNINNNSNNFNNNNNNNNNNNNNNNNN DDB0229350_Ddis FPPNNSNNSFDDPFRDSPRT---------NLSNNPFNVNSNDNSNSSN-----NNNNNNN Nak_Dmel FP---------------------------------------------------------- AKL1_Scer TP---------------------------------------------------------- ARK1_Scer ------------------------------------------------------------ PRK1_Scer L----------------------------------------------------------- AAK1_Spur AA---------------------------------------------------------- AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap ------------------------------------G------AL-----------RPGN AAK1_Hsap ------------------------------------G------LL-----------ASVP BIKE_Mmus ------------------------------------G------AL-----------RPGN AAK1_Mmus ------------------------------------G------LL-----------PSVS sel-5_Cele ------------------------------------K------VPIDFHHRQSFSGEEQL DDB0229347_Ddis NNNNNNNNTNNNNSNNNN--------YNNNN----------------------------- DDB0229350_Ddis NNNNNNNNNGNNITNEEILNIITQLTNNDQTNTFDSGLLLKLKSM-----------KPGK Nak_Dmel ------------------------------------A------MP-----------PAVP AKL1_Scer ------------------------------------G------EL---------YYPSVS ARK1_Scer ------------------------------------------------------------ PRK1_Scer ------------------------------------------------------------ AAK1_Spur ------------------------------------A------AQ------------RLS AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap GPEILLGQGPPQQP-------------PQQHRVLQ----QL---QQGDWRLQQ---LHL- AAK1_Hsap QPK---PQAPPSQPLPQ-TQAKQPQAPPTPQQTPS----TQ---AQGLPAQAQ---ATP- BIKE_Mmus GSEVLMVQGPPQQP-------------PQQHRVLQ----QL---QQGDWRLQQ---LHL- AAK1_Mmus QPK---AQATPSQPLQS-SQPKQPQAPPTPQQTPA----TQ---TQGLPTQAQ---ATP- sel-5_Cele KPA---AEADSAGPLSC-PLIKPTDLGFTDLDKPA-------LPRDRAQTD---GKRRL- DDB0229347_Ddis ------------------------------------------------------------ DDB0229350_Ddis GTMHIIVKRPLKEP-------------LVCFKSLLLVHALL---SEGNNIQFK---SD-- Nak_Dmel PPP---QAVTPAAPAAS-KLFES-SGYPDPFNEPA----AAVIPTEFLPAAEEPNKEEV- AKL1_Scer E---------LDTYLDK-ELVKQSSDPTISEQSPR----LN---TQSLPQRQK---STSS ARK1_Scer --------------------------------HPN----RK---PSQIAYDAS---FSN- PRK1_Scer -----------T--------------------SPL----MK---TKSVPLSDE---FAS- AAK1_Spur PPQV-QAQQAIQQQ-------------QQQQQQQQ----QQ---QQQLLQEQQ---LAQ- AqueK170_Aque ---ITL---------TSISSRERPRSRPISSISPA----SS---SSY------------- BIKE_Hsap ------------------------------------Q---HRH----------------- AAK1_Hsap ------------------------------------Q---HQQ----------------- BIKE_Mmus ----------------------------------------HRH----------------- AAK1_Mmus ------------------------------------Q---HQQ----------------- sel-5_Cele ------------------------------------P---HES----------------- DDB0229347_Ddis ------------------------------------------------------------ DDB0229350_Ddis ------------------------------------V---HDSKDL-------------- Nak_Dmel ------------------------------------P---QDL----------------- AKL1_Scer YSSGGRSMKSTSYGAATIGSDEALANEKTAGINKMKQ---HKSNNPFPKMNVAYHSTNEL ARK1_Scer -------------------------------------SAKGSQ----------------- PRK1_Scer ------------------------------------LYYKELH----------------- AAK1_Spur -----------------------------------QQ---NKQ----------------- AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap ------PHQQQQQ---------------QQQQQQQQQ----------------------- AAK1_Hsap ------QLFLKQQ---------------QQQQQPP---PAQ---------------QQPA BIKE_Mmus ------PHHHHQQ---------------QQQQQQQQQ----------------------- AAK1_Mmus ------QHLLKQQ---------------QQQQQQPQQPTAP---------------PQPA sel-5_Cele ------DIIFQQQ---------------HRRNVSD--TSQI---------------SRSA DDB0229347_Ddis ------NKFDEFE----------------------------------------------- DDB0229350_Ddis ---FN-NLYLGWS---------------KQKDRYLQ------------------------ Nak_Dmel ------NVIAGTPTKSMLTPPKPSGGGGHRRNVS--DTSAF---------------NK-- AKL1_Scer SNDAS-NFFLEEQ---------------QQGQRYQQAQ-NQT------GT---QGNTFPD ARK1_Scer ------PL-FDKS----------------------------------------------- PRK1_Scer ------P--FQKS---------------QTFK---------------------------- AAK1_Spur ----RLLALAQQQ---------------QQQQQQQQQQ--QQLAYNNAQAQAAYGPQQPQ AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap ----QQQ--QQQQQQQQQQ----------------------------------------- AAK1_Hsap GTFYQQQQA------QTQQ----------------------------------------- BIKE_Mmus ----QQQ--LQQQQQQQQQ----------------------------------------- AAK1_Mmus GTFYQQQQQQQQQQAQTQQ----------------------------------------- sel-5_Cele FKPYSSQQT--TSKTSSQV----------------------------------------- DDB0229347_Ddis ------------------------------------------------------------ DDB0229350_Ddis ------------------------------------------------------------ Nak_Dmel -TFA-------------------------------------------------------- AKL1_Scer ESQYQSRVEQQQQQQDQPKGPANYSQRNFYTGRDRSNKPMQLGGTIAGDSGNRRVNFQNI ARK1_Scer ---------------Q-NM----------------------------------------- PRK1_Scer ----SVES------FQSPQ----------------------------------------- AAK1_Spur QVAYAGQQG------FQQP----------------------------------------- AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap --------HHHHH----------------------------------------------- AAK1_Hsap --------FQAVHPATQKPAIA----------------------QFPVVSQG-------- BIKE_Mmus ------------------------------------------------------------ AAK1_Mmus --------FQAVHPAAQQPVTA----------------------QFPVGSQG-------- sel-5_Cele --------VRSVEDMSQ------------------------------------------- DDB0229347_Ddis ------------------------------------------------------------ DDB0229350_Ddis ------------------------------------------------------------ Nak_Dmel ------------------------------------------------------------ AKL1_Scer SQNYATNSQSGYLPSQNSPAIP---------------------MVRPVISMN-------- ARK1_Scer --------YHALDPPLVEPLAS----------------------SV--SN---------- PRK1_Scer --------RKSMPPLSLTPVNN----------------------DI-------------- AAK1_Spur --------YQQPQPTPQQPAFGQHGAFTRPQQLTYEQQQASIQAQYAQQQAALQQQQQQA AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap ---------HHHLLQDAYMQQY----QHA----------TQ-----------QQQML--- AAK1_Hsap -------GSQQQLMQNFYQQQQ----QQQ----------QQQQQQQLATALHQQQLMTQQ BIKE_Mmus ------------LLQNAYLQQY----QHA----------MH-----------QQHIL--- AAK1_Mmus -------GAQQQLMQNFYHQQQ----QQQ----------QQ-----------QQQLMAQQ sel-5_Cele ------------------------------------------------------------ DDB0229347_Ddis ------------------------------------------------------------ DDB0229350_Ddis ---------LGELLSHYSLLL--------------------------------------- Nak_Dmel ------------------------------------------------------------ AKL1_Scer -------QQQAQQIQAQQLQAQ----QMQ----------AKQQMQAKQQMQVQQQLQVQQ ARK1_Scer ----------------------------NDNELKANSATKL-----------KQAIVSEA PRK1_Scer -------------------------------FDRVSAINRP-----------NNYVDSET AAK1_Spur ALQQQQQAALQQQQQAAYQQQQQALLQQQ----------QQQQQQQQAAYLSQQAALEQQ AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap ---QQQFLM-------------HSVYQPQP--------SASQ--YPTMMPQYQQAFFQQQ AAK1_Hsap AALQQKPTM-------------AAGQQPQP--------QPAA--APQPAPAQE--P-AIQ BIKE_Mmus ---QQQFLM-------------HSVYQPQP--------PASQ--YPAMMQQYQQAFLQQQ AAK1_Mmus AALQQKTAV--------------VVPQSQA--------QPAT--APQAAAAQE--PGQIQ sel-5_Cele ------------------------------------------------------------ DDB0229347_Ddis ------------------------------------------------------------ DDB0229350_Ddis ---YKFILFHQKNYMIDGSFAFEEMKWGIPESLDSNNHPISINTIKALFDIMDHLFLVQN Nak_Dmel ------------------------------------------------------------ AKL1_Scer ------------------------------------------------------------ ARK1_Scer HTFRQNNSI--------------D------------------------------------ PRK1_Scer QTIDN---M--------------A------------------------------------ AAK1_Spur AVLQQQQLAYQQQQQLAAQQQQYQASSP-P--------PFSQ--QPQFIPSEQQALYQQQ AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap MLA-Q------------------------------------------------------- AAK1_Hsap APV-R------------------------------------------------------- BIKE_Mmus MLA-R------------------------------------------------------- AAK1_Mmus APV-R------------------------------------------------------- sel-5_Cele ------------------------------------------------------------ DDB0229347_Ddis ----------------SWGNTPLQHP----SPSNSNS-N--VIIN--------------- DDB0229350_Ddis NLSDYCINNICSSNSSGSGNVPISLLQHCVNILNSSSYSIFCFISGSIDVLSKQFSDVDM Nak_Dmel ------------------------------------------------------------ AKL1_Scer ------------------------------------------------------------ ARK1_Scer --------------------FPL------------------------------------- PRK1_Scer --------------------VPN------------------------------------- AAK1_Spur QAALQ------------------------------------------------------- AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap --------HQPSQ---------------QQASPEYLTSPQEF------------------ AAK1_Hsap --------QQPKV---------------QTTPPP-AVQGQKVG-SLTPPSSPKTQRAGHR BIKE_Mmus --------HQQPA---------------QQVSPEYLTSPQEF------------------ AAK1_Mmus --------QQPKV---------------QTTPPP-TIQGQKVG-SLTPPSSPKTQRAGHR sel-5_Cele --------RQNGG---------------S------------------------------- DDB0229347_Ddis ------------------------------------------------------------ DDB0229350_Ddis KLISCVNQFQSMY---------------TRLRE---------Q-YTKLAQ------VP-- Nak_Dmel ---------------------------------------NET------------------ AKL1_Scer ---------QMQI---------------QNAN---------------------------- ARK1_Scer ------------QNIIPQYEDSSSSSDESYS----------------------------- PRK1_Scer ------------LKLSPTITSKSLSSTKEIAAPD-NINGSKIVRSL--SSKLKKVITGES AAK1_Spur --------QQQQQ---------------AQQQQQFLQAQ-----------A--------- AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap ---SPALVSYTSSLPAQVGT---------------------IMD-SSYS-ANRSVADKEA AAK1_Hsap RILSDVTHSAVFGVPASKSTQLLQ--------A-------AAAE-ASLN-KSKSATTTPS BIKE_Mmus ---SPALVSYASSLPAQVGT---------------------IVD-SSYG-ANRSVAEKEA AAK1_Mmus RILSDVTHSAVFGVPASKSTQLLQ--------A-------AAAE-ASLN-KSKSATTTPS sel-5_Cele ------------------------------------------------------------ DDB0229347_Ddis ------------------------------------------------------------ DDB0229350_Ddis -CFSDI---FFPTLPN----TAPT--------F-------TIVRSNSFNRLNSSLSDLNL Nak_Dmel ---SQFLAPFNNNL------AA-MGDGQQTLASAASNPGIYASS-TANS-AAVSIS---- AKL1_Scer ----------------NNGT---------------------------YV-SDRTNHTTED ARK1_Scer -----------GDVDELKKTRSLG--------S--------------------------- PRK1_Scer RGNSPIKSRQNTGDSIRSAFGKLR--------H-------GFTG-NSVN-NSRSAS---- AAK1_Spur ----QALA--QAQAAGAVGT---------------------LVE-VDAA-DH--VSPVQD AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap IANFTNQKNISNPPDMSGWNPFGE--D-------------NFSKLTEEELLDREFDLLRS AAK1_Hsap GSPRTSQQNVYNPSEGSTWNPFDD--D-------------NFSKLTAEELLNKDFAKLGE BIKE_Mmus VANFTNQKTISHPPDMSGWNPFGE--D-------------NFSKLTEEELLDREFDLLRS AAK1_Mmus GSPRTSQQNVSNASEGSTWNPFDD--D-------------NFSKLTAEELLNKDFAKLGE sel-5_Cele ----------------GEWNPFLV--APFSNNSISRKDGQESAFMMDDSHFGMVFDEIRR DDB0229347_Ddis -------NTNS-----SGKNNQNKSNS-------------GNGNF--------------- DDB0229350_Ddis -NNNNNNNNNS-----NNSNNSNN--S-------------NSGNLSGNASLNSSFDNINS Nak_Dmel --ELMKPGQTAVEKRVEAWNPFEE--E------------QPFSQMTEDHIFEAEFDKIRQ AKL1_Scer MRNAQ----GGEPPILAG-NSANE--PMHS-------------S-SKNEALLIELSPLKE ARK1_Scer ------------------------------------------------------------ PRK1_Scer ------------------------------------------------------------ AAK1_Spur LA--------------SPTNPFSP--Q-----SAMLA--SQLPAPPDDEDLDSEFDQLRK AqueK170_Aque ----VSEQ---------------------------------------------------- BIKE_Hsap NRLEERASSD---KNVDS-LSAPHNHPPEDPFGSVPFISHSGSPEKKA--EHSSIN---- AAK1_Hsap GKHPEKLGGS-----AES-LIPGFQSTQGDAFATTSFS--AGTAEKRK--GGQTV----- BIKE_Mmus NRLGASTPSD---KTVDL-PPAPHSRPPEEPFASVPFISHSGSPEKKT--TEHSPN---- AAK1_Mmus GKLPEKLGGS-----AES-LIPGFQPTQGDAFTTPSFS--AGTAEKRK--GGQAV----- sel-5_Cele KEIPAELD--SETS----------SIDSRDPFGAAPFDQLTVSTSSSA--QPVSLPPATD DDB0229347_Ddis ------FDND---FEFEG-FVSPTTNGSTNFEVNTTNTNVSLNSSTHS--SSSFNN---- DDB0229350_Ddis SNP---FSTE---PTFNP-FSATTTNTSESGFGNFGLSEPTSNPSPRY--QQSNNN---- Nak_Dmel RGSQGTAPGAVPPPPIAAAVSPYPSQVSEDPFGSAPFSLPPGLREKAS--SLRKTG---- AKL1_Scer DAGKQS-FQDT---------NEPQTGGIEDAGGS-------------------------- ARK1_Scer ------------------------------------------------------------ PRK1_Scer ------------------------------------------------------------ AAK1_Spur VSPETATN--VAQPQIQGISNPP---HTTDVFGAVPFNLREGRPQSGGAAEMEQIA---- AqueK170_Aque ---------------------------------------------KKP--P--------- BIKE_Hsap -----------------------QENGTANPIKNG--K---------------------- AAK1_Hsap ------------------------------------------------------------ BIKE_Mmus -----------------------QKSITANLTKNG--G---------------------- AAK1_Mmus ------------------------------------------------------------ sel-5_Cele EDDERQLLSETDEEEKYEIDEKEEIQTKKDETINE--E---------------------- DDB0229347_Ddis -----------------------SSNNNNTNNSSV--S---------------------- DDB0229350_Ddis -----------------------NNNNNNNNGTPI--S---------------------- Nak_Dmel -----------------------AKFIGVSSGGTGGGV---------------------- AKL1_Scer -----------------------------------------------------------G ARK1_Scer ------------------------------------------------------------ PRK1_Scer ------------------------------------------------------------ AAK1_Spur -----------------------SGTGSQQTLVQG--HVMESSPPLVGGEGEARKGGHMD AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap ---TSPASKDQR------------------------TGKK-TS----------------- AAK1_Hsap ------------------------------------------------------------ BIKE_Mmus ---SSPLCKDQR------------------------AGKK-TS----------------- AAK1_Mmus ------------------------------------------------------------ sel-5_Cele ---DSEI-DEQR------------------------MNDRRRY----------------- DDB0229347_Ddis ---VG--SSI-------------------------------------------------- DDB0229350_Ddis ---LTPGSLS-------------------------------------------------- Nak_Dmel ---ATPIG--LVAGGANTATSSNSSKWMLSPTLEVSSEEK-TSLISKLKTDSECGIPGAV AKL1_Scer TI----------------------------------KGSN-NN----------------- ARK1_Scer ------------------------------------------------------------ PRK1_Scer ------FDN--------------------------------------------------- AAK1_Spur VFGATPFG-------------LSGGGQAAQPSQ--------------------------- AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap -----------------------VQGQVQKGNDESE---SDF------------------ AAK1_Hsap -----------------------------------D---SGLPLL--------------- BIKE_Mmus -------------------ENPVIRGQVQKGHDDSE---SDF------------------ AAK1_Mmus -----------------------------------D---SGIPLL--------------- sel-5_Cele -------------------SYENIDG----VGDDAS---SD------------------- DDB0229347_Ddis ------------------------------------------------------------ DDB0229350_Ddis ------------------------------------------------------------ Nak_Dmel GGAGEGVSGYVKLPVEDRNKYEKLRSKDQPTSDDSD---SEASEFFQQDSDEGGGGIFRQ AKL1_Scer -------------------------RNGVLNLSLN------------------------- ARK1_Scer ---------------------YSTRGNIKKNQSVKESLTS-------------------- PRK1_Scer ---------------------NNVNGNGNNT---NRRLVS-------------------- AAK1_Spur ----------------------TTQQQQQRHMSPQE------------------------ AqueK170_Aque -------------------------------NNMVQ---SS------------------- BIKE_Hsap ------------------------------------------------------------ AAK1_Hsap ------------------------------------------------------------ BIKE_Mmus ------------------------------------------------------------ AAK1_Mmus ------------------------------------------------------------ sel-5_Cele ------------------------------------------------------------ DDB0229347_Ddis ------------------------------------------------------------ DDB0229350_Ddis ------------------------------------------------------------ Nak_Dmel MQMVTSNLPETIHKIQQVAYHKVDKTAHLPIVKKLRDKTKKPTTAAHQAAQQLNLMAAAV AKL1_Scer ---------------------------------------------------EMDLS---- ARK1_Scer ------------------------------------------------------------ PRK1_Scer ------------------------------------------------------------ AAK1_Spur ----------------------------------------------------ADLLGAMA AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap -----------------------------------------------------------E AAK1_Hsap ----------------------------------------------------------SV BIKE_Mmus -----------------------------------------------------------E AAK1_Mmus ----------------------------------------------------------SV sel-5_Cele ------------------------------------------------------------ DDB0229347_Ddis ------------------------------------------------------------ DDB0229350_Ddis ------------------------------------------------------------ Nak_Dmel AAQAEEAAK------------------------------------------------AAE AKL1_Scer ---------------------------RDDTGAAVSSFSSSSSSAS-------------I ARK1_Scer ---------------------------------------SSLPG---------------T PRK1_Scer ---------------------------------------SS--T---------------S AAK1_Spur TEPQPESASTPRIRVGFEDDFVREGKQEGRSER---LTSTGSSSGGFNLERSIRELDEFG AqueK170_Aque -----------------------------------------------------------F BIKE_Hsap SDPP----------SPKSS-EEEEQDDEEVLQGEQGD--FNDDD--------T-----EP AAK1_Hsap SDPF----------IPLQV-PDAPEK---LIEGL-------------------------- BIKE_Mmus SDPP----------SPKSS-EEEQEDED--AQGEHGD--FNDDD--------T-----EP AAK1_Mmus SDPF----------IPLQV-PDAPEK---LIEGL-------------------------- sel-5_Cele SRGK----------TDRDD-SEEEEDDDS-RR--GGDTSHDEDS--------QNTVGSED DDB0229347_Ddis ------------------------------------------------------------ DDB0229350_Ddis ------------------------------------------------------------ Nak_Dmel SDGD----------SIGSA-SD--------LRAEDDD-LFDENP--------R-----QT AKL1_Scer QQAKLSGRKGSSKR-NNYS-TDELG-DSM-VSSESID--IDLDD--------A-----RR ARK1_Scer SFTP----------TSTKVNLK-------------------------------------- PRK1_Scer SFPK----------FNSDTKRKEESDKNQRL----------------------------- AAK1_Spur AKPF--GSVRQHRGSESSS-D----HEGERLSSSLRD--FSYDTFDSDSIDIR-----KD AqueK170_Aque KDPL----------P--------------------------------------------- BIKE_Hsap ENLGHRPLLMDSEDE----------------------EEEEKHSSD-SDY----EQAKAK AAK1_Hsap ------------------------------------------------------------ BIKE_Mmus ENLGHRPLLMDSEDE----------------------EEDDKHSSD-SEC----EQAKTK AAK1_Mmus ------------------------------------------------------------ sel-5_Cele GEGGSRPLLEDDGLE----------------------D-DDDHELI-SSF----SSS--- DDB0229347_Ddis NNSGTRLMNNSSGSLP------QSRQ--SSFN-----------STP-QQ-Q----QQQFN DDB0229350_Ddis PVIGAK-----KPPLPPNIHHLQQQQHPQQQQQQQQQQQQQQQQQQ-QQQQ----QQQQQ Nak_Dmel QAKQRRPLPTEMDGI----------------------SESVKTCSS-SAYHAECESVTTH AKL1_Scer GKTAERRPLHNERGH----------------------K-DQARSSDASKS----NQFKSK ARK1_Scer ------------------------------------------------------------ PRK1_Scer ------------------------------------------------------------ AAK1_Spur EEHAHRGLLDQEESS----------------------EDESDD----------------- AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap YSDMSSVYRDR-SGSGPTQDLNTILLTSA--------QLSSDVAVETPK--QEFDV-FGA AAK1_Hsap --------------KSP----DTSLLLPDLLPMTDPFGSTSDA--VIEK--ADVAV-ESL BIKE_Mmus RGDTSSLRRDK-PGVAP----DTALLTPA--------RSPADA--LTPS--QEFDV-FGA AAK1_Mmus --------------KSP----DTSLLLPDLLPMTDPFGSTSDA--VIDK--ADVAV-ESL sel-5_Cele ------------------------------------------------------------ DDB0229347_Ddis SSTNSGSYNNL-TSS--------------------------------------------- DDB0229350_Ddis HPQQQGLRFPH-SASLEDAR---------------------------------------- Nak_Dmel EDDVRSRVVVKVRMRKKD----RALVTAT-----GDPSAPSEE--LSPTSSDLLHK-FGD AKL1_Scer --DFSSV------------------------------------STRQPR--QSLDLNFQE ARK1_Scer ------------------------------------------------------------ PRK1_Scer ------------------------------------------------------------ AAK1_Spur -----------------------------------------------DSDHHDFDE-VGA AqueK170_Aque ------------------------------PPPT-------------------------- BIKE_Hsap VPFFAVRAQQP--QQEKN-EKNLPQHRFPAA-----------GLEQEEFDVFTKAPFSKK AAK1_Hsap IPGLEPPV---------------------------------------------------- BIKE_Mmus VPFFAAPAPQS--LQHRGDGKNLSQHAFP---------------EQEDFDVFTKAPFNKK AAK1_Mmus IPGLEPPV---------------------------------------------------- sel-5_Cele -----------ST-------------NYPPLFIGTST----PHTQNPITNP--------- DDB0229347_Ddis ------------------------------------------------------------ DDB0229350_Ddis ------------------------------------------------------------ Nak_Dmel RPLLLDDELDYGSGESKS------STESPVAPI----LPTNPDVQESEEDVFALAPFKLP AKL1_Scer VNLS-------------------------------------------------------- ARK1_Scer ------------------------------------------------------------ PRK1_Scer ------------------------------EKRRSMPPSILSDFDQHERNNS-----RTG AAK1_Spur QPLIGDDGHGLSDAELASL-NL--HEDLPSQKVRKSEPPVAQLIDMTDDDPFSQAPFKAK AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap VNVQECHAVGP---EAHTIPGYPK------------------------------------ AAK1_Hsap ------------------------------------------------------------ BIKE_Mmus VSVQDWPAVGP---DARPLPARPR------------------------------------ AAK1_Mmus ------------------------------------------------------------ sel-5_Cele -----------F----LRDELTPKMIITAPLPTAKNNLDDDWDLGDRWTDRRDTVFERP- DDB0229347_Ddis ------------------------------------------------------------ DDB0229350_Ddis ------------------------------------------------------------ Nak_Dmel VGVPLKRKTKP---KAKPKPSEPEMWTSTPVKSAAV--------GDPS-----TNF---- AKL1_Scer ------------------------------------------------------------ ARK1_Scer ------H----------------------------------------------------- PRK1_Scer SRDY-YR----------------------------------------------------- AAK1_Spur TGS-LKRATEPVGMCALTPPISPPMQEEDPFGEAPF--------N-PR-----SGFERET AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap ------------------------------------------------------------ AAK1_Hsap ------------------------------------------------------------ BIKE_Mmus ------------------------------------------------------------ AAK1_Mmus ------------------------------------------------------------ sel-5_Cele -----ASEHQNVFAPATLPRQATPLVCRFKPDLPTAAPVSIIPSMSNT------------ DDB0229347_Ddis ------------------------------------------------------------ DDB0229350_Ddis ------------------------------------------------------------ Nak_Dmel ----------------------------------ASFPAQ-LTPTNNVGNSA-------- AKL1_Scer ----------SPTLTQEHR----------------------------------------- ARK1_Scer ------------------------------------------------------------ PRK1_Scer ------------------------------------------------------------ AAK1_Spur SKSSVGSTGS---------------------DVFSKAPFL-VSSKKRQGTGSEVRRAKTQ AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap --SVD--VF--GSTPFQPFL-----TSTSKSES----NEDLFGLVPFDEITG--SQQ--- AAK1_Hsap ------------------------------------------------------------ BIKE_Mmus --SVD--IF--GSTPFQPFS-----VSASKSES----KEDVFGLVPFEEITG--SQQ--Q AAK1_Mmus ------------------------------------------------------------ sel-5_Cele ----------------------------SFPEA----VRDS-DTVPCEPII--GTLI--S DDB0229347_Ddis ---------------FNNLN-----ISTSS------------------------------ DDB0229350_Ddis ---------------LYTLI-----LTPSS------------------------------ Nak_Dmel --QLD--EF--NEPIFNPFQ-----ENAQNTQSGETNQCDLFGLEPFPQVIR--TIE--- AKL1_Scer ---------NK------------------------------------------------- ARK1_Scer -----------ENSPFKSTF-----VNT-IDNS----KDDLN-KPSYEDLDV--SKQNLK PRK1_Scer -----------SHSPVKKTQ-----ASA-KTTS----KPTLI--PDNGNVNI--N-QEKK AAK1_Spur HVSGEQTALGNPTPPISPTELGAQGVSSKMSKQ----EPDMFGAVPFHAVASHGSDL--E AqueK170_Aque ---------------------------------------DL------------------- BIKE_Hsap QKVKQRS-------LQK----LSSRQRR-TKQDMSKSNGKRHHGTPTS------------ AAK1_Hsap --------------PQR----LPSQTE--------------------------------- BIKE_Mmus QKVKQRS-------LQK----LSSRQRR-TKQDVSKSNGKRHHGTPTS------------ AAK1_Mmus --------------AQR----LPSQTE--------------------------------- sel-5_Cele V--GAPTDPPPPPLPKKPTEASPTQET------------------TAT------------ DDB0229347_Ddis ------------------------------SASIS-SSGGVSNNSDNS------------ DDB0229350_Ddis ------------------------------SPPLSPSTGPTTAAQQQQQQQQSQHTFDNF Nak_Dmel QNPQHHQ-------IHQ----FPSHNNN---NNVIKVPASVSVALPAS------------ AKL1_Scer -------NDSPAPNSHHSYRVSPHAST--------------------------------- ARK1_Scer NSIQQRM-------IDK----LNSSEESFN-----------------A------------ PRK1_Scer ESIQRRV-------HNL----LKSSDDPVTYKSASGYGKYTDIGTETS------------ AAK1_Spur MSSKEDA----------------------------QQPGPASHKRPHV------------ AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap ---TK-K--TLKPT---------------YRTPERARR------HKK-VGRRDSQSSNE- AAK1_Hsap -----------------------------------------------------SVTSNR- BIKE_Mmus ---AK-K--TLKPP---------------YRTPERARR------HKK-VGRRDSQSSNE- AAK1_Mmus -----------------------------------------------------SVTSNR- sel-5_Cele ---IP-VALGKKEK---------------LLKKE-KKK------EKK-DGKKDKLKLEE- DDB0229347_Ddis ---WN-V--TLTPS---------------QSNKNSTGNLKPLNNNNNNNNNNNNRF--AN DDB0229350_Ddis NINGH-A--PPVPQ---------------STQPSFQPHVSF-APNVNINNNNNSHVSAPH Nak_Dmel ---VP-V--SVSVNSSAPQLVTINHSIIINKTPEPPMN------YNN-NNNNQTAKSSG- AKL1_Scer -----------------------------------------------------AITENK- ARK1_Scer ---RKMS--KVKL----------------------------------------------- PRK1_Scer ---NRHS--SVRIT---------------PITEEKFKK---------------------- AAK1_Spur ---VS-TAVGVRRS---------------SRTSSGGRR-------RR-SGSNSSRSSRR- AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap -FL--------TISDSKEN--ISVA-LTD---GK-DRGNVLQP-EESLLDPFGAKPFHSP AAK1_Hsap -TDSL------TGEDSLLD--CSL--LSN-------------P-TTDLLEEFAPTAIS-- BIKE_Mmus -FL--------TISDSKEN--ISVA-LTD---GK-DRASVLPS-DESLLDPFGAKPFHPP AAK1_Mmus -TDSL------TGEDSLLD--CSL--LSN-------------P-TAGLLEEFAPIALS-- sel-5_Cele -YR--------EKGSSEPETDGSEA-EIW---TN-DGATTFSN-KKKKKSTF-------- DDB0229347_Ddis NTNSSRDYSFDF----SSP--N--T-SNN----N-DFGSFVQPSSSSSLNT---THFSKP DDB0229350_Ddis SLNSSS----------SSI--S--S-ISN----P-NLGGIAQKGSGNSLMP---PPLYKP Nak_Dmel -TSSVYVNVPSFSSMSTSS--C--S-INQ---PQSSPAAVIPV-QAPLPVPV-PAPVSVP AKL1_Scer -RHST------GHE-------LST--RS-------------------------------- ARK1_Scer ------------HEKGEID--KPTMLKSSGPISK-DKK---------------------- PRK1_Scer -----------TLKDGVLD--IKT--KSN---GK-DKS---------------------- AAK1_Spur -SS-----------SSSAS--NSLK--SS---PGSQP--RLRG-SQDSLDAFGSRPFSLA AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap -------------------------------------DLS------------------WH AAK1_Hsap -----------------------------------------------------------A BIKE_Mmus -------------------------------------DL-------------------WH AAK1_Mmus -----------------------------------------------------------A sel-5_Cele ------------------------------------------------------------ DDB0229347_Ddis -------------------------------------NYNVNLN---------------- DDB0229350_Ddis -------------------------------------AARGHRRSQSSNGDEVRRRNLLQ Nak_Dmel AVPVPIPAVVTHLRPLLPIADNAYVQISQDRCSDFTPDDE------------------EE AKL1_Scer ------------------------------------------------NGKHETHRTG-- ARK1_Scer ------------------------------------------------------------ PRK1_Scer ------------------------------------------------------------ AAK1_Spur -------------------------------------DD--------------------- AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap PPHQGLSD--IRADH--------------------NTVLPGRPRQNSLHGSFHSADVLKM AAK1_Hsap PVHKAAED----------------------------------SNLISGFDVPEGSDKVAE BIKE_Mmus QPHQGLSD--ICVDH--------------------TTILPGRPRQNSVHGSFHSAETLRM AAK1_Mmus PTHKAAED----------------------------------SNLISGFGVAEGSEKVAE sel-5_Cele ----------------GLRSS---------------------------------HPSIVA DDB0229347_Ddis ---QTTSMTNNYNNN--------------------NY--------NNNNNSNNNN----- DDB0229350_Ddis ---QQLEQNRDFLNH--------------------NRLLNKQSRMNNPNNLFDEGDS--- Nak_Dmel PVVLRDAD--VVADGIGIPTPAKPKKEKSNLA---VRVLPGKLTQKVKGHSYKKVS---A AKL1_Scer ------------------------------------------------------------ ARK1_Scer --------------------------------------TKPTPPPKPSHL---KPKPP-- PRK1_Scer --------------------------------------RPPRPPPKPLHL---RTEIQKI AAK1_Spur ---------------------GQPKPVDTKLTFEDTFGRKLTPPQS--HKQLVLPLTKAV AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap DD--FG-AVPFTELVVQSITP---------------------------------H---QS AAK1_Hsap DE--FD-PIP--VLITKNPQG---------------------------------G---HS BIKE_Mmus DD--FG-AVPFTELVVQSVTP--------------------------------------- AAK1_Mmus DE--FD-PIP--VLITKNTQG---------------------------------G---HS sel-5_Cele NDLQFSSPMP--PVVKKSSK--------------------------------------DK DDB0229347_Ddis ------------------------------------------------------------ DDB0229350_Ddis ---------------------------------GFG------------------------ Nak_Dmel AA--LG-ST--SSLSSGSKQKHQRLQYQSHDDDDDEQDQDE------N-RGAGGGRNFQS AKL1_Scer -----------------SKQRHDLERYRHSKDK-------------------------DS ARK1_Scer -----------------PKPL---------------------------------L----- PRK1_Scer RN--FS-RLQSKKLPIERISS---------------------------------E---AT AAK1_Spur DD--FG-AQPFTSPDSPA-AP---PAGFDVDVDPFGAAPFKPPAISGPVKRQG-AR--RA AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap Q---QSQPVELD-----PFG---------------------------------------- AAK1_Hsap RNSSGSSESSLPN-LARSLL---------------------------------------- BIKE_Mmus Q---QSQPVELD-----PFG---------------------------------------- AAK1_Mmus RNSSGSSESSLPN-LARSLL---------------------------------------- sel-5_Cele KSSLTGKNASFVN-TSFQPE---------------------------------------- DDB0229347_Ddis -----------------NNS---------------------------------------- DDB0229350_Ddis -----------------DGE---------------------------------------- Nak_Dmel NTIQNSAKTGFSN-MSFEDFPSDQEMDRLSRTIPFEVVRNEKMLLEAEKKFGS------L AKL1_Scer -NSSITISTSTPSEMRKSF-------ARARQSLDLERVRREAMASSASSSGGSNGKRRSF ARK1_Scer ------------------L----------------------------------------A PRK1_Scer E---TIVDVNVD-----DL-------------------------------------EADF AAK1_Spur RESPGDEKSPEKM-SLASRQ---------------------------------------- AqueK170_Aque ------------------F----------------------------------------- BIKE_Hsap AAPFPSKQ AAK1_Hsap LVDQLIDL BIKE_Mmus AAPFPSKQ AAK1_Mmus LVDQLIDL sel-5_Cele DHDDPTDL DDB0229347_Ddis KVFDFGIL DDB0229350_Ddis EEDEGLLN Nak_Dmel KRRNNLFS AKL1_Scer FSVFRSEK ARK1_Scer GRKLSLDK PRK1_Scer RKRFPSKV AAK1_Spur RRSFQTDL AqueK170_Aque ---GQAPF