CLUSTAL W (1.83) multiple sequence alignment CG6114_Dmel MQKENN---------------------------------VTAENCQFVGPYRLEKTLGKG BRSK2_Mmus MTSTGKDGG-------------------------------GAQHAQYVGPYRLEKTLGKG BRSK1_Mmus MSSGSKEGGGGS-PAYHL---------------PH-PHPHPPQHAQYVGPYRLEKTLGKG sad-1_Cele MFEALKEVLGEI-NS-KLAA--VNNELSSKIMSENIVSTRPVAQAQYCGPYKLEKTLGKG BRSK1_Hsap MVAGLTLGKGPESPDGDVSVPERKDEVAGGGGEEE-EAEERGRHAQYVGPYRLEKTLGKG BRSK2_Hsap MTSTGKDG--------------------------------GAQHAQYVGPYRLEKTLGKG DDB0229364_Ddis M------------------------------------------EIHSVGPFIIGKTLGQG BRSK_Spur MSSG---------------------------------------DTQYVGPYKLEKTLGKG AqueK058_Aque MATDE-------------------------------------SNTRAVGPYLLQKTLGKG * . : **: : ****:* CG6114_Dmel QTGLVKLGVHCVIGKKVAIKIINREKLSE--SVLMKVEREIAIMKLIDHPHVLGLSDVYE BRSK2_Mmus QTGLVKLGIHCVTCQKVAIKIVNREKLSE--SVLMKVEREIAILKLIEHPHVLKLHDVYE BRSK1_Mmus QTGLVKLGVHCITGQKVAVKIVNREKLSE--SVLMKVEREIAILKLIEHPHVLKLHDVYE sad-1_Cele QTGLVKTGTHCITGRKVAIKIVNKEKLSE--SVLQKVEREIAIMKLIEHPHVLHLYDVYE BRSK1_Hsap QTGLVKLGVHCITGQKVAIKIVNREKLSE--SVLMKVEREIAILKLIEHPHVLKLHDVYE BRSK2_Hsap QTGLVKLGVHCVTCQKVAIKIVNREKLSE--SVLMKVEREIAILKLIEHPHVLKLHDVYE DDB0229364_Ddis TTGKVKLGFHKDTGFKVGIKIINKELLINKPSMRRKIEREIVLMKLIDHPNAMKMYEVYE BRSK_Spur QTGLVKLGVHCVSGKKVAIKIINKEKLSE--SVLMKVEREIAIMKLIEHPHVLGLYDVYE AqueK058_Aque QTGLVKLGVHCTTGKTVAVKIINREKLSK--SVLMKVEREIAIMKLIDHPHVLGLHDVYE ** ** * * .*.:**:*:* * : *: *:****.::***:**:.: : :*** CG6114_Dmel NKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPEN BRSK2_Mmus NKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPEN BRSK1_Mmus NKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPEN sad-1_Cele NKKYLYLLLEHVSGGELFDYLVRKGRLMSKEARKFFRQIISALDFCHAHNICHRDLKPEN BRSK1_Hsap NKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPEN BRSK2_Hsap NKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPEN DDB0229364_Ddis TSKYLFLILEYVEGGELFDYLVEKGGLESGEALFFFQQIIIGLEYCHSRNICHRDLKPEN BRSK_Spur NRKYLYLILEHVAGGELFDYLVKKGRLTPREARRFFRQIISAIDFCHSYSICHRDLKPEN AqueK058_Aque NNVHLYLVLEHVSGGELFDYLVRKGRLSEREARRFFKQIVSAVDFCHKHSVCHRDLKPEN . :*:*:**:* *********.** * ** **:**: .:::** .:********* CG6114_Dmel LLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVIL BRSK2_Mmus LLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVIL BRSK1_Mmus LLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVIL sad-1_Cele LLLDERNNIKVADFGMASLQVEGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVIL BRSK1_Hsap LLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVIL BRSK2_Hsap LLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVIL DDB0229364_Ddis LLLSGDKRIKIADFGMGSIVRKDMLLHTSCGSPHYASPEVVSGIDYDGQKADVWSCGVIL BRSK_Spur LLLDDKNNIRVADFGMASLQLDSSLLETSCGSPHYACPEVIRGEKYDGRKADVWSAGVIL AqueK058_Aque LLLDDQRNIKVADFGMASLQVTGTLLETSCGSPHYACPEVIRGENYDGRKADVWSLGVIL ***. ..*::*****.*: . :*.*********.***: * .***::**:** **** CG6114_Dmel YALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINR BRSK2_Mmus FALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQK BRSK1_Mmus FALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQK sad-1_Cele YALLVGALPFDDDNLRNLLEKVKRGVFHIPHFVPADVQSLLRAMIEVDPGKRYSLADVFK BRSK1_Hsap FALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQK BRSK2_Hsap FALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQK DDB0229364_Ddis YALLTGKLPFDDENIRRLLNKVKNGAFSMPPYIHKDAQDLLTKMLTVDPSKRISIKEIKE BRSK_Spur YALLVGALPFDDDNLRNLLEKVKRGVFHIPHFVPPDCQNLLRGMVEVNADKRLTLSQIQR AqueK058_Aque FALLVGSLPFDDDNLRVLLEKVKRGRFNIPTYVPAGAQELIRGMVDVNPKSRLTLDKVMR :***.* *****:*:* **:***.* * :* :: . *.*: *: *:. * :: .: . CG6114_Dmel HPWVTAGGKGE-LELE-LP-MMEVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQEL BRSK2_Mmus HIWYI-GGKNE-PEPE-QPI-PRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDL BRSK1_Mmus HPWYL-GGKHE-PDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHREL sad-1_Cele HPWVS-GTT-K-ADPELELPMSQVVQTHVIPGEDSIDPDVLRHMNCLGCFKDKQKLINEL BRSK1_Hsap HPWYL-GGKHE-PDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHREL BRSK2_Hsap HIWYI-GGKNE-PEPE-QPI-PRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDL DDB0229364_Ddis HPWFV-SNFNQ-FQKA-T-PV-EEINAEPLVDYSQIDEDIFRSLMALGVGT-IDEVKQQL BRSK_Spur HPWYV-GTRNE-NQPESDIPKKHHIKIPPILGDEDVDPDVIGSMTSLGCFKDRPKLLRNL AqueK058_Aque HAWFQ-GSFSLDGVIEPVLPMGEVVQTYPLLDRSDIDPDVFDGMTSLGCFRDKHKLMTNL * * . . : : :* *:: : .** .: :* CG6114_Dmel LSSSHNTEKVIYFLLLERKRRRPALEDDDEIAQKSRSELDAV-DPPRKRL---------- BRSK2_Mmus LSEEENQEKMIYFLLLDRKERYPSHEDEDLP---PR---NEI-DPPRKRV---------- BRSK1_Mmus RSEEENQEKMIYYLLLDRKERYPSCEDQDLP---PR---NDV-DPPRKRV---------- sad-1_Cele LSPKHNTEKMVYFLLLDRKRRRPAQEDDTEIVLR--GAAQNN-DPPKKRT---------- BRSK1_Hsap RSEEENQEKMIYYLLLDRKERYPSCEDQDLP---PR---NDV-DPPRKRV---------- BRSK2_Hsap LSEEENQEKMIYFLLLDRKERYPSQEDEDLP---PR---NEI-DPPRKRV---------- DDB0229364_Ddis VSNQK-SATLIYYRLLEERKKFDSDVNKYGYKPKE-TRRNSLSDMSLKKIFSGSNNNNNN BRSK_Spur LSPHHNSEKVIYSLLLDRKQRKPSFEDELEYR--TR--SDSA-DPPRKRV---------- AqueK058_Aque LAPEHNEEKIIYFLLLERKDKKPSLADEARVN--VG---QQR-DPPRKRV---------- : . .::* **:.: : : :. : * . *: CG6114_Dmel ------------------------------------------------------------ BRSK2_Mmus ------------------------------------------------------------ BRSK1_Mmus ------------------------------------------------------------ sad-1_Cele ------------------------------------------------------------ BRSK1_Hsap ------------------------------------------------------------ BRSK2_Hsap ------------------------------------------------------------ DDB0229364_Ddis NNNNNNNNNNNNNNNNNNNNNNNNNNNININNNNNNNNNNNNNNNNNNNNNNNNNNNNNN BRSK_Spur ------------------------------------------------------------ AqueK058_Aque ------------------------------------------------------------ CG6114_Dmel ---------DTCRIN------G--TNAP----SYG--QI----SEGS------------- BRSK2_Mmus ---------DSPMLN------RHGKRRPER-KSMEVLSVTD---GGS------------- BRSK1_Mmus ---------DSPMLS------RHGKRRPER-KSMEVLSITDAGSGGS------------- sad-1_Cele ---------DSSRTS------RY---------PMG--SI----ADGS------------- BRSK1_Hsap ---------DSPMLS------RHGKRRPER-KSMEVLSITDAGGGGS------------- BRSK2_Hsap ---------DSPMLN------RHGKRRPER-KSMEVLSVTD---GGS------------- DDB0229364_Ddis NNSAVGKSNDSSSQQPPHIQQPHSQQIPSNSTSQESMQISPSNSANNMAIQQPIINNNNN BRSK_Spur ---------DSYHR-----------RRSER-KSFD---MT---RDGS------------- AqueK058_Aque ---------DSQAVL--------------------------------------------- *: CG6114_Dmel ---------------------------PL----TPRRQAFNFRSYSSTRNHQRRSPTTV- BRSK2_Mmus ---------------------------PV-----PARRAIEMAQHGQ-RSRS-------- BRSK1_Mmus ---------------------------PV-----PTRRALEMAQHSQ-RSRS-------- sad-1_Cele ---------------------------PI-----NPRKTYGRNQKSG-RHSS-------- BRSK1_Hsap ---------------------------PV-----PTRRALEMAQHSQ-RSRS-------- BRSK2_Hsap ---------------------------PV-----PARRAIEMAQHGQ-RSRS-------- DDB0229364_Ddis NNNNNNNINNNINNNINNNINNNSNNVNRPTSEGLLKQALQ--QHHQQQQQQ-----FNG BRSK_Spur ---------------------------MS-----PARRAMSH-HNSG-RSRS-------- AqueK058_Aque ----------------------------------------PSSIQMQ-RVRS-------- : . CG6114_Dmel -TS--SV------RSSSYHSPTRCNSPMSSAQQQANAISRPSSPAAGTRHSTYGDRDRSG BRSK2_Mmus ---------------ISGASSGLSTSPLSSPRVT-------------------------- BRSK1_Mmus ---------------VSGASTGLSSSPLSSPRSPVFSF--SPEPGAG-------D----- sad-1_Cele ---------------LG-------GSPTESPRSSTRDLFG--SSSSGSYSARAGEDRDRG BRSK1_Hsap ---------------VSGASTGLSSSPLSSPRSPVFSF--SPEPGAG-------D----- BRSK2_Hsap ---------------ISGASSGLSTSPLSSPRVT-------------------------- DDB0229364_Ddis NNNNNTMNVQPLTMSASSSSSSSSTTPSLSPNSS-------------------------- BRSK_Spur ---------------VT-------SSPLASPTHS-------------------------- AqueK058_Aque ---------------QSIGSAGLDVSP--------------------------------- :* CG6114_Dmel HHSSVSRTPSHSSQKSIEGDVV-----VVR--EPRIERRDSLRQERGGGSPRDRGDC-GI BRSK2_Mmus ------------------------------------------------------------ BRSK1_Mmus -------------------------------------------EARGGGSPTSKTQ--TL sad-1_Cele RSASRSTNSYHYYTQPVDPQTLAEAARHVRDAQERRESR---DSGRGSSRKESKDRSDKS BRSK1_Hsap -------------------------------------------EARGGGSPTSKTQ--TL BRSK2_Hsap ------------------------------------------------------------ DDB0229364_Ddis ------------------------------------------------------------ BRSK_Spur ------------------------------------------------------------ AqueK058_Aque ------------------------------------------------------------ CG6114_Dmel PPGSPGGNSSGSTSASPSVHHRANSGPTIAII---VNP-----NGSPM---MNN-----S BRSK2_Mmus --------------PHPSPRGSPLPTPKGT----------------PVHT-PKESPAGTP BRSK1_Mmus PSRGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTP-----LHSPLHT-PRASPTGTP sad-1_Cele ASSSSCKNDASSTS------SVPHKYSPPSVMSESVVV-----SSSTMNS-TNSSTNSLI BRSK1_Hsap PSRGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTP-----LHSPLHT-PRASPTGTP BRSK2_Hsap --------------PHPSPRGSPLPTPKGT----------------PVHT-PKESPAGTP DDB0229364_Ddis ----------------------TTSSTSTSPQLSAIK---------PDHYQRRGSMT--A BRSK_Spur --------------PRQVCR----QH-SGSSLV----------STGSGST-PPASPTATS AqueK058_Aque --------------PPPRSRGTPSVPPSYTPPTGYYSYSSNQKEKGGGPS-RKISMAGHE : CG6114_Dmel SPG-MP----G-SPCNTPGGQLWKTRLTNIKNSFLGSPRFHRRKMQVSA-DEV-H-LTPE BRSK2_Mmus NPT-PP----S-SP--SVGGVPWRTRLNSIKNSFLGSPRFHRRKLQVPTPEEMSN-LTPE BRSK1_Mmus GTT-PP----P-SPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSS-LTPE sad-1_Cele AGN-S-------QTSIGSTSGPWRSKLNNIKNSFLGTPRFHRRKMSNGTAESDSEDSQMI BRSK1_Hsap GTT-PP----P-SPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSS-LTPE BRSK2_Hsap NPT-PP----S-SP--SVGGVPWRARLNSIKNSFLGSPRFHRRKLQVPTPEEMSN-LTPE DDB0229364_Ddis ST-NPATSPTMS-HRGKTS-SP-----------IE--ITSKVRKLKIS---ESQSN-TPN BRSK_Spur QQG---------QQQQGGQSTPWRARLNSLKNTILGSPRFHRRKMQPAEPDEL-S-LTPD AqueK058_Aque CQTLPPTVVTTTAAGETGGASPWKRRLSTTLKTIVSSPRFHRKRFEET-PSEG--G-AVG : : :::. . CG6114_Dmel SS--PELTKRSWFGNL---ITTEK--DETFTILVKGKPIAT--VKAH------------- BRSK2_Mmus SS--PELAKKSWFGNF---INLEK--EEQIFVVIKDKPLSS--IKAD------------- BRSK1_Mmus SS--PELAKRSWFGNF---ISLDK--EEQIFLVLKDKPLSS--IKAD------------- sad-1_Cele DT--TDLVKKSWFGSLASSMSVER--DDTHCVPVQGKTLNS--IKAE------------- BRSK1_Hsap SS--PELAKRSWFGNF---ISLDK--EEQIFLVLKDKPLSS--IKAD------------- BRSK2_Hsap SS--PELAKKSWFGNF---ISLEK--EEQIFVVIKDKPLSS--IKAD------------- DDB0229364_Ddis SPIIGSSPKKSWFSYF---FSKNS--SSNNLNAANGSAPSSPSLQSNGVGQLQTTQANYV BRSK_Spur NS--PEMSKKSWFSSF---MGAERAVDEELSIAVRDKSLSS--IKAE------------- AqueK058_Aque AS--PQTAKRSWFSNF---KVDKE--NEEVVVVYRDKTGAE--LKQL------------- . . *:***. : . .. .... :: CG6114_Dmel --------LIHAFL-----------------------SMAELSHSVVSPTSFRVEYKR-- BRSK2_Mmus --------IVHAFL-----------------------SIPSLSHSVISQTSFRAEYKA-- BRSK1_Mmus --------IVHAFL-----------------------SIPSLSHSVLSQTSFRAEYKA-- sad-1_Cele --------LIRAFL-----------------------QIHELSHSVVGQNCFRVEYKRGP BRSK1_Hsap --------IVHAFL-----------------------SIPSLSHSVLSQTSFRAEYKA-- BRSK2_Hsap --------IVHAFL-----------------------SIPSLSHSVISQTSFRAEYKA-- DDB0229364_Ddis IESKIDVNLIYVNLEKIIKKYGFELKYQQQQQQQNIKHCIVRSHHINSDGTPQFECEIE- BRSK_Spur --------LVQAFL-----------------------TIPDMSHSVHSTTSFKAEFKR-- AqueK058_Aque --------LLKAFT------------------------VVNVSSELIGDNLYKCKYQKST :: . * : . : : : CG6114_Dmel ---NGNGPVMFQRHVKFQVDISAIC-----------------------KQGDIADMLFAL BRSK2_Mmus ---TG-GPAVFQKPVKFQVDITYTEGGE----------------------AQKENGIYSV BRSK1_Mmus ---SG-GPSVFQKPVRFQVDISSSEGPEPSP-----R-----------RDGSSGGGIYSV sad-1_Cele ---TV-GGSVFSRGIKMNVDIIPSPQQV---------------------VIAGETPTYVV BRSK1_Hsap ---SG-GPSVFQKPVRFQVDISSSEGPEPSP-----R-----------RDGSGGGGIYSV BRSK2_Hsap ---TG-GPAVFQKPVKFQVDITYTEGGE----------------------AQKENGIYSV DDB0229364_Ddis ----I-KPSTFINPVSPSKQHHHHHHQQQQP-----QQQQMPPLNLNGGQNINHDQGFRV BRSK_Spur ---AG-SGAVFAKPIKFQVEILTPDGSE----------------------AAKENVVHIL AqueK058_Aque EAESK-GKTILKKKVKFTVAIIPVQRRRGSTVSADMQ-----------TNSVFDGQTHSM : . : . : CG6114_Dmel TFTLLSGNIRRFRRICEHIQSQVCSKRFP-GPSS--PPTVTSV-TQAVSES--SSCGSVS BRSK2_Mmus TFTLLSGPSRRFKRVVETIQAQLLSTHDQPSAQH--LSDTTNCMEVMTGRL--SKCGTPL BRSK1_Mmus TFTLISGPSRRFKRVVETIQAQLLSTHDQPSVQA--LAD--------------------- sad-1_Cele QFVLLAGPVRRFKRLVEHLSAILQNSTQQRADRQ--QQ-A--ALMVRPRRLSDSSVGSAC BRSK1_Hsap TFTLISGPSRRFKRVVETIQAQLLSTHDQPSVQA--LAD--------------------- BRSK2_Hsap TFTLLSGPSRRFKRVVETIQAQLLSTHDPPAAQH--LSDTTNCMEMMTGRL--SKCGSPL DDB0229364_Ddis SIIHKSGSQHKFNNFTSS------------------------------------------ BRSK_Spur HFLLISGPIRRFRRLVELIQARLTSSRVN-STES--LPGPI--------RS--SSTGSSS AqueK058_Aque TFEQTSGALRRFHRVCDKIQAVMAGDSLTGGVVRPKASSTASGSPIMMGEFVDSE----- : :* ::*... . CG6114_Dmel S----ERLSYKRQVI---ENDME---------N----DSIFSYKSGNGRR-ASTTN-N-N BRSK2_Mmus S----NFFDVIKQLF---SD----------------------EKNGQAAQ-APSTP-AKR BRSK1_Mmus ------------------------------------------EKNGAQTR-PAGTP-P-R sad-1_Cele SDSESNASSI--NMIARHSDKTETTSATSSDPYG-PSPSMRSVGSGTANSYKSPTP-HRR BRSK1_Hsap ------------------------------------------EKNGAQTR-PAGAP-P-R BRSK2_Hsap S----NFFDVIKQLF---SD----------------------EKNGQAAQ-APSTP-AKR DDB0229364_Ddis ------------------------------------------------------------ BRSK_Spur S----TSVDY-------------------------------------------AVS-P-R AqueK058_Aque -----------------------TRSGSSDDTLTLHSTNGVSHDSGKGSS-ASVDVFIHR CG6114_Dmel NANPV-------D---IPGSPIAVR-SN------SE-------TAEHERNR-E--LQSER BRSK2_Mmus SAHGP------------LGDSAAAG--PGGDTEYPM-------GKDMAKMG-P---P--- BRSK1_Mmus SLQPP------------PGRSD------------PD-------LSSSPRRG-P---PKDK sad-1_Cele NTTAVTASSSSASNRYGPSSSSSGSYSNNADYSYHPEYSQRSNGSSAPKNQYSPGSQRSF BRSK1_Hsap SLQPP------------PGRPD------------PE-------LSSSPRRG-P---PKDK BRSK2_Hsap SAHGP------------LGDSAAAGPGPGGDAEYPT-------GKDTAKMG-P---P--- DDB0229364_Ddis ------------------------------------------------------------ BRSK_Spur PINPA-----------------FSE--DDGDEVFSD-------GRSVSREG-LMADAAKD AqueK058_Aque ATNPVL-STGGS-SKVG---------G----ASRPS-I------LD-------------- CG6114_Dmel QATTMSGSAIA BRSK2_Mmus ----AARREQP BRSK1_Mmus KLLATNGTPLP sad-1_Cele AFSMFNKADKV BRSK1_Hsap KLLATNGTPLP BRSK2_Hsap ----TARREQP DDB0229364_Ddis ----LEQILTI BRSK_Spur RASSQVSNSIC AqueK058_Aque SSDSDDVLDED