CLUSTAL W (1.83) multiple sequence alignment cdc2_Dmel M----------------------------------------------------------- CDC2_Mmus M----------------------------------------------------------- K03E5.3_Cele MSREIRSLESI------------------------------------------------- cdk-1_Cele MDPIREG-EVA------------------------------------------------- CDC2_Hsap M----------------------------------------------------------- 21071_Tthe MQMDNQE----------------------------------------------------- 21599_Tthe MNNNT------------------------------------------------------- 23583_Tthe MDVQQK------------------------------------------------------ 25533_Tthe MATNILQSQVS------------------------------------------------- 25907_Tthe MLTY-------------------------------------------------------- 26482_Tthe MFQNTNF-NCNQEGQSQRINSNVQGSSGKERRQQNQSQKMNNQQKNEQRSKQKNRRSSRK 6129_Tthe MMDIEFQ----------------------------------------------------- 6298_Tthe MENLEN------------------------------------------------------ 9560_Tthe MAFVIDK-DSK------------------------------------------------- CDC2_Spur M----------------------------------------------------------- n1179_Tthe FGQCRFI----------------------------------------------------- CC1G_02703_Ccin ------------------------------------------------------------ AqueK094_Aque MS---------------------------------------------------------- CDC2-2_Smoe ------------------------------------------------------------ CDC2-1_Smoe ------------------------------------------------------------ GK021_Glam MIFPDLR----------------------------------------------------- GK020_Glam MSVSAA------------------------------------------------------ GK022_Glam MATH-------------------------------------------------------- cdc2_Dmel -------------------------------------------ED-FE-KIEKIGEGTYG CDC2_Mmus -------------------------------------------ED-YI-KIEKIGEGTYG K03E5.3_Cele ------------ISDARENTHEKMLIRKQRDMTTDIAPERDLQGR-FC-SLRRIGEGTYG cdk-1_Cele ----------------------------------HEGDSVYTLND-FT-KLEKIGEGTYG CDC2_Hsap -------------------------------------------ED-YT-KIEKIGEGTYG 21071_Tthe -----------------------------------QNQVEKFIGK-YE-VLNVIGKGTYG 21599_Tthe ----------------------------------------FGSDR-YE-KLLKVGEGTYG 23583_Tthe --------------------------------------RKVYNQK-YL-RIKKINEGSFG 25533_Tthe ------------L--GHQ--------------EDKKQCFNEIPDR-FK-CLQKIGEGTYG 25907_Tthe ---------------------------------------QNFQTR-YV-QLEKLGEGTYG 26482_Tthe SQSKNSNNNATQIE--QQ-NQQ-----------QELINNQRV-ESAQN-SNKKIGQSTNS 6129_Tthe ------------------------------------TKVERLEDK-FQ-KIKMLGEGTYG 6298_Tthe --------------------------------------LETIEDR-YQ-KIKKIGEGTYG 9560_Tthe --------------------------------NFHIEAAQPELER-YQ-RTEKIGEGTYG CDC2_Spur -------------------------------------------ED-FM-KIEKLGEGTYG n1179_Tthe -------------------------------------------GE-FT-QIHQLGEGTFG CC1G_02703_Ccin ------------------------------------------------------MAGTYG AqueK094_Aque ------------------------------------------VDD-YT-KLEKIGEGTYG CDC2-2_Smoe ----------------------------------------------YE-KVEKIGEGTYG CDC2-1_Smoe ----------------------------------------------YE-KVEKIGEGTYG GK021_Glam -------------------------------------PDESGAKE-YTDLVTLIGSGTYG GK020_Glam -------------------------------------PSATSIDR-YR-RITKLGEGTYG GK022_Glam ----------------------------------------PLPKD-YE-FISQIGEGTYG .: . cdc2_Dmel V----------------------------------------------------------- CDC2_Mmus V----------------------------------------------------------- K03E5.3_Cele V----------------------------------------------------------- cdk-1_Cele V----------------------------------------------------------- CDC2_Hsap V----------------------------------------------------------- 21071_Tthe E----------------------------------------------------------- 21599_Tthe E----------------------------------------------------------- 23583_Tthe K----------------------------------------------------------- 25533_Tthe I----------------------------------------------------------- 25907_Tthe V----------------------------------------------------------- 26482_Tthe TLSSSIQSSPSSYTSQFPSISEITQLTVLKGNSNNYTNKTNFLSSPNENSYQDSPAQNQQ 6129_Tthe H----------------------------------------------------------- 6298_Tthe K----------------------------------------------------------- 9560_Tthe I----------------------------------------------------------- CDC2_Spur V----------------------------------------------------------- n1179_Tthe K----------------------------------------------------------- CC1G_02703_Ccin V----------------------------------------------------------- AqueK094_Aque V----------------------------------------------------------- CDC2-2_Smoe V----------------------------------------------------------- CDC2-1_Smoe V----------------------------------------------------------- GK021_Glam D----------------------------------------------------------- GK020_Glam E----------------------------------------------------------- GK022_Glam T----------------------------------------------------------- cdc2_Dmel ------------------------------------------------------------ CDC2_Mmus ------------------------------------------------------------ K03E5.3_Cele ------------------------------------------------------------ cdk-1_Cele ------------------------------------------------------------ CDC2_Hsap ------------------------------------------------------------ 21071_Tthe ------------------------------------------------------------ 21599_Tthe ------------------------------------------------------------ 23583_Tthe ------------------------------------------------------------ 25533_Tthe ------------------------------------------------------------ 25907_Tthe ------------------------------------------------------------ 26482_Tthe QRSVSPVKEERKYDSDDQENNPSLANLQTSNTNNSINNIQNNNNMNIHINQMNQSIASNN 6129_Tthe ------------------------------------------------------------ 6298_Tthe ------------------------------------------------------------ 9560_Tthe ------------------------------------------------------------ CDC2_Spur ------------------------------------------------------------ n1179_Tthe ------------------------------------------------------------ CC1G_02703_Ccin ------------------------------------------------------------ AqueK094_Aque ------------------------------------------------------------ CDC2-2_Smoe ------------------------------------------------------------ CDC2-1_Smoe ------------------------------------------------------------ GK021_Glam ------------------------------------------------------------ GK020_Glam ------------------------------------------------------------ GK022_Glam ------------------------------------------------------------ cdc2_Dmel ------------------------------------------------------------ CDC2_Mmus ------------------------------------------------------------ K03E5.3_Cele ------------------------------------------------------------ cdk-1_Cele ------------------------------------------------------------ CDC2_Hsap ------------------------------------------------------------ 21071_Tthe ------------------------------------------------------------ 21599_Tthe ------------------------------------------------------------ 23583_Tthe ------------------------------------------------------------ 25533_Tthe ------------------------------------------------------------ 25907_Tthe ------------------------------------------------------------ 26482_Tthe NLGISNFMNGNSSQSNHLSHIHQHHSHNLQQMCCPLNNSSNLNSMISSNNFDINNTSSCH 6129_Tthe ------------------------------------------------------------ 6298_Tthe ------------------------------------------------------------ 9560_Tthe ------------------------------------------------------------ CDC2_Spur ------------------------------------------------------------ n1179_Tthe ------------------------------------------------------------ CC1G_02703_Ccin ------------------------------------------------------------ AqueK094_Aque ------------------------------------------------------------ CDC2-2_Smoe ------------------------------------------------------------ CDC2-1_Smoe ------------------------------------------------------------ GK021_Glam ------------------------------------------------------------ GK020_Glam ------------------------------------------------------------ GK022_Glam ------------------------------------------------------------ cdc2_Dmel ------------------------------------------------------------ CDC2_Mmus ------------------------------------------------------------ K03E5.3_Cele ------------------------------------------------------------ cdk-1_Cele ------------------------------------------------------------ CDC2_Hsap ------------------------------------------------------------ 21071_Tthe ------------------------------------------------------------ 21599_Tthe ------------------------------------------------------------ 23583_Tthe ------------------------------------------------------------ 25533_Tthe ------------------------------------------------------------ 25907_Tthe ------------------------------------------------------------ 26482_Tthe EKSSSKQRNVNGKGKKYGYKHGQMNLNCDQNSLNGKEQHKTCQINCEQALCQNNKSLRNL 6129_Tthe ------------------------------------------------------------ 6298_Tthe ------------------------------------------------------------ 9560_Tthe ------------------------------------------------------------ CDC2_Spur ------------------------------------------------------------ n1179_Tthe ------------------------------------------------------------ CC1G_02703_Ccin ------------------------------------------------------------ AqueK094_Aque ------------------------------------------------------------ CDC2-2_Smoe ------------------------------------------------------------ CDC2-1_Smoe ------------------------------------------------------------ GK021_Glam ------------------------------------------------------------ GK020_Glam ------------------------------------------------------------ GK022_Glam ------------------------------------------------------------ cdc2_Dmel ------------------------------------------------------------ CDC2_Mmus ------------------------------------------------------------ K03E5.3_Cele ------------------------------------------------------------ cdk-1_Cele ------------------------------------------------------------ CDC2_Hsap ------------------------------------------------------------ 21071_Tthe ------------------------------------------------------------ 21599_Tthe ------------------------------------------------------------ 23583_Tthe ------------------------------------------------------------ 25533_Tthe ------------------------------------------------------------ 25907_Tthe ------------------------------------------------------------ 26482_Tthe SNLLKSLKFSPLLAQQQQVTQSLMTLPFELHFIICSYLSPKDIYLRLANVNQYFRKMCKD 6129_Tthe ------------------------------------------------------------ 6298_Tthe ------------------------------------------------------------ 9560_Tthe ------------------------------------------------------------ CDC2_Spur ------------------------------------------------------------ n1179_Tthe ------------------------------------------------------------ CC1G_02703_Ccin ------------------------------------------------------------ AqueK094_Aque ------------------------------------------------------------ CDC2-2_Smoe ------------------------------------------------------------ CDC2-1_Smoe ------------------------------------------------------------ GK021_Glam ------------------------------------------------------------ GK020_Glam ------------------------------------------------------------ GK022_Glam ------------------------------------------------------------ cdc2_Dmel ---------------------------------VYKGRN-RLTGQIVAMKK----IRLE- CDC2_Mmus ---------------------------------VYKGRH-RVTGQIVAMKK----IRLE- K03E5.3_Cele ---------------------------------VFKAIH-VRDNVKCALKM----IRTD- cdk-1_Cele ---------------------------------VYKGKN-RRTNAMVAMKK----IRLE- CDC2_Hsap ---------------------------------VYKGRH-KTTGQVVAMKK----IRLE- 21071_Tthe ---------------------------------VFRARD-QETHEIVALKK----TITK- 21599_Tthe ---------------------------------VYKAKD-IQSSEIVALKK----IKLE- 23583_Tthe ---------------------------------IILCELVDQKGQYCVLKK----FKVT- 25533_Tthe ---------------------------------VYKGFD-TQTNTQVAIKK----VKLD- 25907_Tthe ---------------------------------VFKAQD-MQTQQLVAIKQ----IRIDP 26482_Tthe TRLWSYIQKFQTLTINDKYQKNIPVVERRSKGRLFSAVS-RLDHNQFMIRNVNIMISNA- 6129_Tthe ---------------------------------VTKCQD-KQTKEVVAVKK----IKLEI 6298_Tthe ---------------------------------VFQAKD-LKTDQIVALKK----VKND- 9560_Tthe ---------------------------------VYKAID-MQTNDIIALKK----IRLE- CDC2_Spur ---------------------------------VYKGKH-KRTGKIVALKK----IRLE- n1179_Tthe ---------------------------------VYKAQD-KKNNEIVAVKQ----VKIH- CC1G_02703_Ccin ---------------------------------VYKARD-TSTNTIVALKK----IRLE- AqueK094_Aque ---------------------------------VYKARH-KVTGKTVALKK----IRLE- CDC2-2_Smoe ---------------------------------VYKARD-RITNETIALKK----IRLD- CDC2-1_Smoe ---------------------------------VYKARD-RITNETIALKK----IRLD- GK021_Glam ---------------------------------VYRCQH-KQTKTWYAIKR----IKEG- GK020_Glam ---------------------------------VYKAID-TVTNETVAIKR----IRLE- GK022_Glam ---------------------------------VSKCS---LHGQLLAVKR----IKMDS : :: cdc2_Dmel SD---DEGVPSTAIREISLLKELK----------------HENIVCLEDVLME------- CDC2_Mmus SE---EEGVPSTAIREISLLKELR----------------HPNIVSLQDVLMQ------- K03E5.3_Cele RD---EEGIPSTCLREISCIKDLQ----------------HDNIVTLFDIIYASHFLNYN cdk-1_Cele SE---DEGVPSTAVREISLLKELQ----------------HPNVVGLEAVIMQ------- CDC2_Hsap SE---EEGVPSTAIREISLLKELR----------------HPNIVSLQDVLMQ------- 21071_Tthe LE---NDGIPSSALREISLLKEIN----------------HENVVVLKDIIIQ------- 21599_Tthe NE---DEGVPSTALREISILKELQ---------------PHPNIVCMHEVIYQP------ 23583_Tthe Q----QSAIDELSIKEIYYMKKLD----------------HPNLVKSDDIFKIK------ 25533_Tthe QE---QEGIPQSALREICILKDLS---------------DHQNIVKLRDVIYQI------ 25907_Tthe NE---DEGVPSTTLREISILKKLK----------------HKNIVKLLDVYVFP------ 26482_Tthe GQ---DDGVPTSILRELSYLQALD----------------HPNITKIHEVDIK------- 6129_Tthe FQ---GDGFPSSSMREISTLKKM----------------KHENIVILKDVQFQF------ 6298_Tthe YEEIGDEGIPSTALREISCLKALD----------------HPNVVKLVDVVYIM------ 9560_Tthe HE---DEGVPSTAIREISLLKEID----------------HPNVIKLRDLVYG------- CDC2_Spur SE---EEGVPSTAIREISLLKELY----------------HPNIVMLEDVLME------- n1179_Tthe DE---REGFPVTSVREIKLLSELQ---------------NHPNIVQFKEVVVGQ------ CC1G_02703_Ccin AE---DEGVPSTAIREISLLKELK----------------DDNIVKLLDIVHA------- AqueK094_Aque NE---EEGVPSTAIREISILKEVQ----------------HTNVVKLEDIIHQ------- CDC2-2_Smoe QE---DEGVPSTAIREISLLKEMQ----------------HGNIVRLQDVVHC------- CDC2-1_Smoe QE---DEGVPSTAIREISLLKEMQ----------------HGNIVRLQDVVHC------- GK021_Glam KES--KMGLTGDKFMEILAFRELS----------------HPNILSCKSIFFH------- GK020_Glam HE---EEGVPGTAIREVSLLKELQ----------------HRNIIELKSVIHH------- GK022_Glam -S---SKGVPATTLREVAILKALNAKQRELVEQGKLESLSQANVVNLLDVVYD------- .. . *: : : . *: : cdc2_Dmel ---------ENRIYLIFEFLSMDLKKYMDSLPV----------D--KHMESELVRSYLYQ CDC2_Mmus ---------DSRLYLIFEFLSMDLKKYLDSIPP----------G--QFMDSSLVKSYLHQ K03E5.3_Cele NIFFEKFSSNSKLYMVFEFIDRDLKNLLEMLEP----------T-NSVLPPNYVKSFMWQ cdk-1_Cele ---------ENRLFLIFEFLSFDLKRYMDQLGK----------D--EYLPLETLKSYTFQ CDC2_Hsap ---------DSRLYLIFEFLSMDLKKYLDSIPP----------G--QYMDSSLVKSYLYQ 21071_Tthe ---------NNLLYLVFEFCESDLKKFLDSK---------------TKVAGQFLDALTIK 21599_Tthe --------QEKKLYLVFEFVDQDLKKFLDQYRK----------DKKLQLRPYQIKLMMYQ 23583_Tthe --------KSYNGQDFFEQLYMHLPYYLEMSEV-----------PRENLSVEAIKILIKQ 25533_Tthe --------EESKLFLVFEYVDYDLKKYLETMK---------------HLTQHDIKLIMYQ 25907_Tthe --------EAQKVSLVFEYYPQDLRGYLKQLQQ----------KNQKEIPLSFYQNQFRQ 26482_Tthe ---------NVIVQIVTKRQEYNLKEYTRRYISQVQDDSKGLTRPQYKIPLIKVKEIAYQ 6129_Tthe --------DENSLLMVFECLECDLKQYLENEF---------------PIQPIKIKQIMKQ 6298_Tthe --------KKNKLYLVFEYIDYDLKAYQKKIG---------------KIPEQTVKSYMHQ 9560_Tthe ---------ENKLYLIFDYLDHDLKKYLELN--------------GGPLPPAVVKDYLFQ CDC2_Spur ---------PNRLYLVFEYLTMDLKKYMESLK-----------G--KQMDPALVKSYLHQ n1179_Tthe --------NQNSIFLIFEYCQMDIANLIFRMD-----------QEREYFSESEIKCIILQ CC1G_02703_Ccin ---------DQKLYLVFEFLDVDLKRFIETGNQ----------N-RSPITPALVKKFTHQ AqueK094_Aque ---------DLKLYLVFEFMCMDLKKYLDSLPA----------G--KFMEPDLVKSYTYQ CDC2-2_Smoe ---------EKKLYLVFEYLDLDLKKHMDNSP-------------DFAKSPRMIKTFLYQ CDC2-1_Smoe ---------EKKLYLVFEYLDLDLKKHMDNSP-------------DFAKSPRMIKTFLYQ GK021_Glam ---------GARLCFALELCNTSLKSILNSG---------------HSLTAEDRRTAYYQ GK020_Glam ---------NHRLHLIFEYAENDLKKYMDKNP---------------DVSMRVIKSFLYQ GK022_Glam ---------LSNIFLVFEYCHVDLDQYLKHN----------------VLSPYQIKKFMYQ . : : cdc2_Dmel ITSAILFCHRRRVLHRDLKPQNLLIDKS----------------------GLIKVADFGL CDC2_Mmus ILQGIVFCHSRRVLHRDLKPQNLLIDDK----------------------GTIKLADFGL K03E5.3_Cele LLSALSYCHLRRIVHRDLKPQNILVSDS----------------------GVIKIADFGL cdk-1_Cele ILQAMCFCHQRRVIHRDLKPQNLLVDNN----------------------GAIKLADFGL CDC2_Hsap ILQGIVFCHSRRVLHRDLKPQNLLIDDK----------------------GTIKLADFGL 21071_Tthe IIRGVAACHTRRIMHRDLKPQNILIDKN----------------------------DFGL 21599_Tthe ILNGLNFCHSRRIIHRDLKPQNILIDAK----------------------GNIKIADFGL 23583_Tthe LIEAVHFLHQKKIIHRDIKPSNIFLDKT----------------------GKLLLGDMGI 25533_Tthe LLNGLDFCHQRRIIHRDIKPQNILIDKA----------------------GNVKIADFGL 25907_Tthe IIEGVDYCHSQGILHRDLKPQNILVSST----------------------GEIKIADFGL 26482_Tthe ILEGLNYLHHQGIMHRNLKIDNILLDK-----------------------DVVKISDFGL 6129_Tthe ILQGVDYCHQMQIMHRDLKPQNILVSTKAN------------------NTMSVKISDFGL 6298_Tthe ILKGIEHCHSRRIFHRDLKPQNILVNNK----------------------GDIKIADFGL 9560_Tthe LILGIAVCHANRIVHRDLKPQNILINKK----------------------GSVQLADFGL CDC2_Spur MVDGILFCHSRRILHRDLKPQNLLIDNN----------------------GTIKLADFGL n1179_Tthe LLNGVQHMHKQYQMHRDIKLSNVLINDK----------------------GVVKIADFGL CC1G_02703_Ccin LNSGLLYCHSHRILHRDLKPQNLLIDKH----------------------NNLKLADFGL AqueK094_Aque ILKGIVFCHGRRIIHRDLKPQNLLIDNN----------------------GGIKIADFGL CDC2-2_Smoe MIRGLAYCHSHRVLHRDLKPQNLLIDRR---------------------TNALKLADFGL CDC2-1_Smoe MIRGLAYCHSHRVLHRDLKPQNLLIDRR---------------------TNALKLADFGL GK021_Glam ILLGLEYLHRNHISHFDLKPDNILIKDNN-------------------GSSVFKITDFGL GK020_Glam LINGVNFCHSRRCLHRDLKPQNLLLSVSDA-----------------SETPVLKIGDFGL GK022_Glam LLQGLSLVHKNEILHRDIKPNNILLAFRGDAGEQLAANASVTTPNPDADNCVLKITDFGL : .: * * ::* .*::: *:*: cdc2_Dmel GRS---FGIP-VRIYTH-----------EIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIF CDC2_Mmus ARA---FGIP-IRVYTH-----------EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIF K03E5.3_Cele ARN---FSFP-SRNYTH-----------EVVTLWYRPPEILLGSQRYSTSLDMWSLGCIF cdk-1_Cele ARA---IGIP-IRVYTH-----------EVVTLWYRAPEILMGAQRYSMGVDMWSIGCIF CDC2_Hsap ARA---FGIP-IRVYTH-----------EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIF 21071_Tthe SRT---FCMP-IRPYTK-----------EVVTLWYRPPEILLGALDYCTPIDMWSVGCIM 21599_Tthe ARA---FGVP-IKTLTH-----------EVETLWYRAPEILLGQKAYSLGVDIWSLGCIF 23583_Tthe SRD---FPENKDQELTG-----------NTITRLYRPPEILFGCKKYNETVDLWSLGCTI 25533_Tthe AKT---FQVP-SKTLTH-----------EVETLWYRPPEILLGVKTYSLAIDMWSIGCVF 25907_Tthe ARA---FNYP-LKELTK-----------DIVTLWYRSTELLLGESQYDIAIDMWSVGCIL 26482_Tthe SRL---VSIP-HIPYTPEDPKERERSGREARRLWYRAPELLLRKSIYTFEIDMWSFGCLL 6129_Tthe AKT---FTTP-LDKYTK-----------EIATLWYRAPEVMLGDEHYSITIDIWAVGCIF 6298_Tthe GKI---FGIP-LNTITH-----------EVETLWYRAPEILLGDKLYSLPVDVWSIGCIF 9560_Tthe ARA---FGLP-LKTYTH-----------EVVTLWYRPPEILLGQKQYSTPVDIWSIGCIF CDC2_Spur ARA---FGIP-VRVYTH-----------EVVTLWYRAPEVLLGSTRYACPIDMWSLGCIF n1179_Tthe ARE---YNKP-NKPYTP-----------KVVTLWYRSPELLLEMEQYTTSIDIW------ CC1G_02703_Ccin ARA---FGIP-MRTYTH-----------EVVTLWYRAPEVLLGSRHYSTAIDMWSVGCIF AqueK094_Aque GRA---FGIP-VRAYTH-----------EVVTLWYRAPEVLLGCPRYSCPLDIWSIGCIF CDC2-2_Smoe ARA---FGIP-VRTFTH-----------EVVTLWYRAPEILLGSRHYSTPVDMWSVGCIF CDC2-1_Smoe ARA---FGIP-VRTFTH-----------EVVTLWYRAPEILLGSRHYSTPVDMWSVGCIF GK021_Glam SLITGRFRGP-SIVYTGPG---------FRWTPIYRPPEVFGSTLEVGQSSDMWSIGLTF GK020_Glam ARA---FGIP-IRQFTH-----------EIITLWYRPPEILLGSRHYSTSVDIWSIACIW GK022_Glam ARS---YGIN-VTSISA-----------NVVSLWYRAPELVLASKTYSTAVDMWSMGCIM . : **..*:. *:* cdc2_Dmel AEMA--TR-KPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNTFPCWSTNQLTN CDC2_Mmus AELA--TK-KPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLAS K03E5.3_Cele SEIA--SN-KPLFPGECEISQLFKIFEIVGTPNIKSWPGVDSFPHYKAVFPQWPV-NLKK cdk-1_Cele AEMA--TK-KPLFQGDSEIDELFRIFRVLGTPTELEWNGVESLPDYKATFPKWRENFLRD CDC2_Hsap AELA--TK-KPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLAS 21071_Tthe ---------------------------ILGTPTENDWPGIKDLTDYKPTFPRFRPQKLSE 21599_Tthe HEMV--EK-RALFMGDSEIDQIFKIFQYHGTPTEQTWPALKECPYFKPIYPRFKTADPKT 23583_Tthe AEFFMDHK-KYFFQGKSEIDQLCKVFEIRGSANEQNWPGCTELPYYM-DFGELNQKDLSS 25533_Tthe YELM--EK-KPLFISDSEIEAIFKIFQFHGTPNSETFQGLEDYPYFKSTFPRFHAQDPFI 25907_Tthe AEFV--TF-KPLFMGDSQIDQLFKIFQFSGTPNGVIWPNVKKYIDFKQTFPKFLPSNTLR 26482_Tthe AEIV--LN-EPLFAGDSEIEQLFKVFKFIGSPDSETLMSMCDNPDYQQTFPKWKMINLSH 6129_Tthe IELI--TK-RPPFHAQSQIDQLFQIFQIFGTPNEQTYPGISKLPDYNEKFPKFQAQGIQK 6298_Tthe AELI--IG-HPLFHGDSEIDQIFKIFQFFGTPKSSKLEGTYNLKYWSNLFPRFKSQKDEI 9560_Tthe SEMA--QK-IPLFIGDSEIDQIFKIFRIMGTPSESTWPGVTQLPDFKNTFPRWNPIPLQK CDC2_Spur AEMV--TK-RPLFHGDSEIDQLFRIFRTLGTPTDDIWPGVTQLQDYKSTFPMWTKPNIKG n1179_Tthe ------------------------------------------------------------ CC1G_02703_Ccin AEMA--MQGAPLFPGDSEIDQIFKIFRLLGTPNEDIWPGVSTLPDYKPTFPNWSRQDLAK AqueK094_Aque AEMS--NK-KPFFQGDSEIDQLFRIFRILGTPSDAIWPSVTTMPNFKSTFPKWTGKSLSQ CDC2-2_Smoe AEMI--NQ-RPLFPGDSEIDELFKIFRILGTPNEETWPGVTSLPDFKSAFPKWLPKDLAT CDC2-1_Smoe AEMI--NQ-RPLFPGDSEIDELFKIFRILGTPNEETWPGVTSLPDFKSAFPKWLPKDLAT GK021_Glam FEMI--IQ-TAVIQAE-ESRIPAKIADLLGRLPNDTDPGVTD---WHGSFINLCGKDYSP GK020_Glam AEML--MK-TPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTALPDWKQSFPKFRGKTLKR GK022_Glam YFLA--NK-RALFQVRKDADLLQLAFSYFYVDS-SSISDLISLPNWNMYVGENQVIDLAA cdc2_Dmel Q-------------------------------LK-NLDANGIDLIQKMLIYDPVHRISAK CDC2_Mmus H-------------------------------VK-NLDENGLDLLSKMLVYDPAKRISGK K03E5.3_Cele LE-ET-----------------------------SCLTGNGLDVLREILRYPPERRLTAK cdk-1_Cele KF-YD-----------------------KKTGKH-LLDDTAFSLLEGLLIYDPSLRLNAK CDC2_Hsap H-------------------------------VK-NLDENGLDLLSKMLIYDPAKRISGK 21071_Tthe MI-ENIY--------------------KKYNQN-SEVDIAAVDLLQRLLCYDPIKRITAK 21599_Tthe YF-K-------------------------------NFCDKGFDLIQQMIALDPAKRISVK 23583_Tthe L-------------------------------LP-KAPKECIEIIDSLLQLCPQKRAKIE 25533_Tthe VF-K-------------------------------NLENDARDLLMQMIALNPLDRISVK 25907_Tthe ID-PRF--------------------------KE-QIRNEGIELIESLLQIVPEKRLNSD 26482_Tthe IC-EQNQSEEFKQLKTTMIPNRQNGFQKLKNLGT-ILGMQGMQLLNSLLQLNPYKRISSQ 6129_Tthe L-----------------------------LPS-NFNDPEALDLLSNLLVLDPSRRIFSK 6298_Tthe LK-PI-----------------------------IETDPQAADLLVKLIDIEPAKRISVS 9560_Tthe Q-------------------------------CP-NICPKGIDLLTKMLQLDPTKRITAE CDC2_Spur A-------------------------------VK-GMDEGGLDLLEQMLIYDPAKRITAK n1179_Tthe ------------------------------------------------------------ CC1G_02703_Ccin A-------------------------------VP-TLDEAGIDMLKRTLTYDSAKRLSAK AqueK094_Aque L-------------------------------CP-HLDSIGCDLLMQMVIYNPGKRISAK CDC2-2_Smoe L-------------------------------VP-GLEHAGVDLLSKMLCLDPSSRITAR CDC2-1_Smoe L-------------------------------VP-GLEHAGVDLLSKMLCLDPSSRITAR GK021_Glam PT-QPYM--------------------HTLFER-HGVRPEEKQFIAKFLQYSPEARITAA GK020_Glam V-------------------------------LGALLDDEGLDLLTAMLEMDPVKRISAK GK022_Glam LNAPG-R--------------------KPREVD-INIDDVGKDLFYKLLMLNPSKRISCD cdc2_Dmel DILEHPYFNGFQS----------------------------------------------- CDC2_Mmus MALKHPYFDDLDN----------------------------------------------- K03E5.3_Cele GALSHRYFLQNGFTQNRPSV-------TDLMKDIR------------------------- cdk-1_Cele KALVHPYFDNMDTSKLPAG----------------------------------------- CDC2_Hsap MALNHPYFNDLDN----------------------------------------------- 21071_Tthe SALNHIKIQLDS------------------------------------------------ 21599_Tthe DALRHPYFEDLSREDIAK------------------------------------------ 23583_Tthe DIIQNKWLQSTTEQGFQEL----------------------------------------- 25533_Tthe QALLHPYFDSLTESEKTAY----------------------------------------- 25907_Tthe EALKAPFFKL-------------------------------------------------- 26482_Tthe EALNHPFFDEIRQQRTLMNIPMQIDETININKCCSQVVPSCYFQFSLPYCHLSTIYQTMV 6129_Tthe EALKHPYFNG-------------------------------------------------- 6298_Tthe QALKHPYFDNIQSPL--------------------------------------------- 9560_Tthe EALDHPYFDDLDKSN--------------------------------------------- CDC2_Spur ASMRHPYFDNILPLSD-------------------------------------------- n1179_Tthe ------------------------------------------------------------ CC1G_02703_Ccin RALVHPYFADYNN----------------------------------------------- AqueK094_Aque RAMEHPYFQGLRKS---------------------------------------------- CDC2-2_Smoe AALEHDYFKDAASAGVDPS----------------------------------------- CDC2-1_Smoe AALEHDYFKDAASAGVDPST-------VIPRLGIK------------------------- GK021_Glam DALQDPFLANCNKSCNILD----------------------------------------- GK020_Glam NALEHPYFSHND------------------------------------------------ GK022_Glam EALQHPWFDDLK------------------------------------------------ cdc2_Dmel ------------------------------------------------------------ CDC2_Mmus ------------------------------------------------------------ K03E5.3_Cele ------------------------------------------------------------ cdk-1_Cele ------------------------------------------------------------ CDC2_Hsap ------------------------------------------------------------ 21071_Tthe ------------------------------------------------------------ 21599_Tthe ------------------------------------------------------------ 23583_Tthe ------------------------------------------------------------ 25533_Tthe ------------------------------------------------------------ 25907_Tthe ------------------------------------------------------------ 26482_Tthe KQEKIETLIKPDYMKDQALITENMRIILIDWLTDVSVHFEAQDETLHYCISYIDRALGIM 6129_Tthe ------------------------------------------------------------ 6298_Tthe ------------------------------------------------------------ 9560_Tthe ------------------------------------------------------------ CDC2_Spur ------------------------------------------------------------ n1179_Tthe ------------------------------------------------------------ CC1G_02703_Ccin ------------------------------------------------------------ AqueK094_Aque ------------------------------------------------------------ CDC2-2_Smoe ------------------------------------------------------------ CDC2-1_Smoe -----------------------------KWD---------------------------- GK021_Glam ------------------------------------------------------------ GK020_Glam ------------------------------------------------------------ GK022_Glam ------------------------------------------------------------ cdc2_Dmel ------------------------------------------------------------ CDC2_Mmus ------------------------------------------------------------ K03E5.3_Cele ------------------------------------------------------------ cdk-1_Cele ------------------------------------------------------------ CDC2_Hsap ------------------------------------------------------------ 21071_Tthe ------------------------------------------------------------ 21599_Tthe ------------------------------------------------------------ 23583_Tthe ------------------------------------------------------------ 25533_Tthe ------------------------------------------------------------ 25907_Tthe ------------------------------------------------------------ 26482_Tthe NIDKQKLQLVGVSCMKIADVFNERSREYYKQENAIEYAYITAEEYNAAQLIAMEKKILKV 6129_Tthe ------------------------------------------------------------ 6298_Tthe ------------------------------------------------------------ 9560_Tthe ------------------------------------------------------------ CDC2_Spur ------------------------------------------------------------ n1179_Tthe ------------------------------------------------------------ CC1G_02703_Ccin ------------------------------------------------------------ AqueK094_Aque ------------------------------------------------------------ CDC2-2_Smoe ------------------------------------------------------------ CDC2-1_Smoe -ID--------------------------------------------------------- GK021_Glam ------------------------------------------------------------ GK020_Glam ------------------------------------------------------------ GK022_Glam ------------------------------------------------------------ cdc2_Dmel ------------------------------------------------------------ CDC2_Mmus ------------------------------------------------------------ K03E5.3_Cele --A---Q------NR-T------------------------------------------- cdk-1_Cele ------------------------------------------------------------ CDC2_Hsap ------------------------------------------------------------ 21071_Tthe ------------------------------------------------------------ 21599_Tthe ------------------------------------------------------------ 23583_Tthe --K---Q-F-AE-NN-IQ------------------------------------------ 25533_Tthe --N---Q----------------------------------------------------- 25907_Tthe ------------------------------------------------------------ 26482_Tthe LSF---Q------LN-TPNMMYFLKIMCTLFDTDSQVSVIAMFLADLLLMSYEALRFKPS 6129_Tthe ------------------------------------------------------------ 6298_Tthe ------------------------------------------------------------ 9560_Tthe ------------------------------------------------------------ CDC2_Spur ------------------------------------------------------------ n1179_Tthe ------------------------------------------------------------ CC1G_02703_Ccin ------------------------------------------------------------ AqueK094_Aque ------------------------------------------------------------ CDC2-2_Smoe ------------------------------------------------------------ CDC2-1_Smoe --V---QTMHMDQAKVIT------------------------------------------ GK021_Glam --RDRYE------RN-L------------------------------------------- GK020_Glam ------------------------------------------------------------ GK022_Glam ------------------------------------------------------------ cdc2_Dmel ------------------------------------------------------------ CDC2_Mmus ------------------------------------------------------------ K03E5.3_Cele -----------------PPL---------------------------------------- cdk-1_Cele ------------------------------------------------------------ CDC2_Hsap ------------------------------------------------------------ 21071_Tthe ------------------------------------------------------------ 21599_Tthe -----------------F-E---------------------------------------- 23583_Tthe -----------------SNI---------------------------------------- 25533_Tthe -----------------Y-N---------------------------------------- 25907_Tthe ------------------------------------------------------------ 26482_Tthe LLASCCIFLSFLTNERELPT------QEKLNEVRSLLDHYTINEFKEAAEFVRKFWHYYR 6129_Tthe ------------------------------------------------------------ 6298_Tthe ------------------------------------------------------------ 9560_Tthe ------------------------------------------------------------ CDC2_Spur ------------------------------------------------------------ n1179_Tthe ------------------------------------------------------------ CC1G_02703_Ccin ------------------------------------------------------------ AqueK094_Aque ------------------------------------------------------------ CDC2-2_Smoe ------------------------------------------------------------ CDC2-1_Smoe -----------------LEF---------------------------------------- GK021_Glam -----------------PPLQRVMYGP--------------------------------- GK020_Glam ------------------------------------------------------------ GK022_Glam ------------------------------------------------------------ cdc2_Dmel --------------------------------------GLVRN CDC2_Mmus --------------------------------------QIKKM K03E5.3_Cele ---------------------------------LNNHQEKSIF cdk-1_Cele ----------------------------------NYRGELELF CDC2_Hsap --------------------------------------QIKKM 21071_Tthe ------------------------------------SLFIQLN 21599_Tthe ------------------------------------PNQVHMY 23583_Tthe ---------------------------------HKILHPPERF 25533_Tthe ---------------------------------TNQYMKFFSI 25907_Tthe -----------------------------------------TQ 26482_Tthe SDPNTLNFQSVYNKYAVVYGLEARLINAPIIEQAQYSQWIYTK 6129_Tthe ------------------------------------------V 6298_Tthe ------------------------------------NSQIFNF 9560_Tthe --------------------------------------YKLLD CDC2_Spur ------------------------------------RLQPIRS n1179_Tthe ------------------------------------------- CC1G_02703_Ccin ---------------------------------------NYKA AqueK094_Aque ---------------------------------------ILPL CDC2-2_Smoe ---------------------------------TVSVQKGCKC CDC2-1_Smoe ---------------------------------TSSSKLPFHR GK021_Glam ---------------------------------FDEKIGSNDM GK020_Glam ----------------------------------------FDP GK022_Glam -----------------------------------------KG