CLUSTAL W (1.83) multiple sequence alignment cdc2c_Dmel MTT--ILDNFQRAEKIGEGTYGIVYKARSNSTG---QDVALKKIRLEGETEGVPSTAIRE CDK2_Mmus ------MENFQKVEKIGEGTYGVVYKAKNKLTG---EVVALKKIRLDTETEGVPSTAIRE CDC28_Scer MSG--ELANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIRE CDK2_Hsap ------MENFQKVEKIGEGTYGVVYKARNKLTG---EVVALKKIRLDTETEGVPSTAIRE CDK3_Hsap ------MDMFQKVEKIGEGTYGVVYKAKNRETG---QLVALKKIRLDLEMEGVPSTAIRE Cdc2_Ddis MESDGGLSRYQKLEKLGEGTYGKVYKAKEKATG---RMVALKKIRL--EDDGVPSTALRE CDK2_Spur ------MNNFEKIEKIGEGTYGVVYKARDLKSG---KTVALKKIRLDTESEGVPSTAIRE AqueK096_Aque ------MDGYERLEKIGEGTYGVVYKARQATHGN--RVVALKKIRLDAECEGVPSTAIRE : ::: **:****** **** . * . ******** * :******:** cdc2c_Dmel ISLLKNLKHPNVVQLFDVVISG-NNLYMIFEYLNMDLKKLMDKKKDV--FTPQLIKSYMH CDK2_Mmus ISLLKELNHPNIVKLLDVIHTE-NKLYLVFEFLHQDLKKFMDASALT-GIPLPLIKSYLF CDC28_Scer ISLLKELKDDNIVRLYDIVHSDAHKLYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMM CDK2_Hsap ISLLKELNHPNIVKLLDVIHTE-NKLYLVFEFLHQDLKKFMDASALT-GIPLPLIKSYLF CDK3_Hsap ISLLKELKHPNIVRLLDVVHNE-RKLYLVFEFLSQDLKKYMDSTPGS-ELPLHLIKSYLF Cdc2_Ddis ISLLKEVPHPNVVSLFDVLHCQ-NRLYLVFEYLDQDLKKYMDSVPA---LCPQLIKSYLY CDK2_Spur IALLKELDHKNIVKLHDVVHSD-KKLYLVFEFMNQDLKKYMDVAPPS-GLPPGLVKSYLQ AqueK096_Aque ISILKELDHVNIVSLLDVLYCD-RKLFMVFEFLDYDLKKYMDRHAPT-GIP-----TARA *::**:: . *:* * *:: ..*:::**:: ***: *: : . cdc2c_Dmel QILDAVGFCHTNRILHRDLKPQNLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYR CDK2_Mmus QLLQGLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEVVTLWYR CDC28_Scer QLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYR CDK2_Hsap QLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYR CDK3_Hsap QLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYR Cdc2_Ddis QLLKGLAYSHGHRILHRDLKPQNLLIDRQGALKLADFGLARAVSIPVRVYTHEIVTLWYR CDK2_Spur QLLQGIAFCHAHRVLHRDLKPQNLLIDADGRIKLADFGLARAFGVPVRTYTHEVVTLWYR AqueK096_Aque KLLEGVAYCHAHRVLHRDLKPQNLLISSDGRIKLADFGLARAFGVPVRTYTHEVVTLWYR :: ..:.:.* :*::**********:. * :**.*******..:*:*.****:****** cdc2c_Dmel APEILLGTKFYSTGVDIWSLGCIFSEM--------------------------------- CDK2_Mmus APEILLGCKYYSTAVDIWSLGCIFAEMHLVCTQHHAKCCGEHRRNGRHSLCPLCSYLEVA CDC28_Scer APEVLLGGKQYSTGVDTWSIGCIFAEM--------------------------------- CDK2_Hsap APEILLGCKYYSTAVDIWSLGCIFAEMHLVGTQHHARCCGEHRRNGRQSLCPLCSYLEVA CDK3_Hsap APEILLGSKFYTTAVDIWSIGCIFAEM--------------------------------- Cdc2_Ddis APEVLLGSKSYSVPVDMWSVGCIFGEM--------------------------------- CDK2_Spur APEILLGCRYYSTAVDIWSLGCIFVEM--------------------------------- AqueK096_Aque SPELLLGSQYYSTPVDIWSIGCIFAEM--------------------------------- :**:*** : *:. ** **:**** ** cdc2c_Dmel ---------------IMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPDFKTKFP CDK2_Mmus ASQGGGMTAVSAPHPVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP CDC28_Scer ---------------CNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPDFKPSFP CDK2_Hsap ASQGWGMTAVSTPYPVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP CDK3_Hsap ---------------VTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFP Cdc2_Ddis ---------------LNKKPLFSGDCEIDQIFRIFRVLGTPDDSIWPGVTKLPEYVSTFP CDK2_Spur ---------------ITRRALFPGDSEIDQLFRIFRTMGTPDEKLWPGVTSLPDYKTSFP AqueK096_Aque ---------------VTKRPLFPGDSEIDQLFRIFRTLGTPDESVWPGISSFPDYKSSFP ::.:*.**.****:::*** :.**.: **.: :*:: .** cdc2c_Dmel RWEGTNMPQ--PITEHEAHELIMSMLCYDPNLRISAKDALQHAYFRNVQHVDHVALPVDP CDK2_Mmus KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK-PV------- CDC28_Scer QWRRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQE------------- CDK2_Hsap KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK-PV------- CDK3_Hsap KWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQY--- Cdc2_Ddis NWPGQPYNKIFPRCEPLALDLIAKMLQYEPSKRISAKEALLHPYFGDLDTS--------- CDK2_Spur RWTPQDFTKIVPMLNKDGKDLLKSMLCYEPDKRISAKTGLSHPYFKDVKMVPP------- AqueK096_Aque KWPRQNLQRIVKSLDTLGINLLEQMLCYEPCKRITAINGMRHPFFS-------------- .* . : . .*: .:* *:* **:* . *.:* cdc2c_Dmel NAGSASRLT-RLV CDK2_Mmus --------PHLRL CDC28_Scer ------------S CDK2_Hsap --------PHLRL CDK3_Hsap ------VLQRFRH Cdc2_Ddis -----------FF CDK2_Spur --------PRLPT AqueK096_Aque ------------E