CLUSTAL W (1.83) multiple sequence alignment Cdk4_Dmel MSYVRQL--------------------------KRQKMSQAKK----------------- CDK6_Mmus MEKD--------------------------------SLSR-------------------- CDK4_Mmus MA---------------------------------------------------------- cdk-4_Cele MTIRHILAIRKKSLELPSDLKTFLRVLANCQHLKKNKKCRRTIFSVDFQNNQRQKPSNFH CDK4_Hsap MA---------------------------------------------------------- CDK6_Hsap MEKD--------------------------------GLCR-------------------- CDK4_Spur MASS--------------------------------APSR-------------------- * Cdk4_Dmel ---------------------------------FGDGDPFNYQELNIIGEGAYGTVYRAR CDK6_Mmus ------------------------------------A-DQQYECVAEIGEGAYGKVFKAR CDK4_Mmus --------------------------------------ATRYEPVAEIGVGAYGTVYKAR cdk-4_Cele FWTVIKKFSKKILKSFIIKFGNNGTIAVVFSIFPTGATPSLTFLFQALGKGAYGNVYRVR CDK4_Hsap --------------------------------------TSRYEPVAEIGVGAYGTVYKAR CDK6_Hsap ------------------------------------A-DQQYECVAEIGEGAYGKVFKAR CDK4_Spur ------------------------------------STPERYVQAAEIGSGAYGIVYKAR :* **** *::.* Cdk4_Dmel DVIT-GNIVALKKVRISLN---ENGVPMSTLREISLLKQLNASNHANIVKLYEVCQFLER CDK6_Mmus DLKNGGRFVALKRVRVQTS---EEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRT CDK4_Mmus DPHS-GHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLEAFEHPNVVRLMDVCATSRT cdk-4_Cele SLHD-GKDYALKQIMISSK---NEGIPQSVLREITVMKHLARKAHPNIISLKSVFHQLDP CDK4_Hsap DPHS-GHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRT CDK6_Hsap DLKNGGRFVALKRVRVQTG---EEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRT CDK4_Spur DTET-GHFVALKSVRIPIG---EEGMPVSTIREISLLRHLCQLDHPNIVKLLDVCDVMDV . *. *** : : *:* *.:**::::::* *.*:: * .* Cdk4_Dmel DG-QLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHRIIHRDLK CDK6_Mmus DR-ETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLK CDK4_Mmus DR-DIKVTLVFEHIDQDLRTYLDKAPPPGLPVETIKDLMRQFLSGLDFLHANCIVHRDLK cdk-4_Cele VRAILKINMIMERCDWDLHTFLRNIP-RGVPEQQAKHVTAQIVRALDFLHTHSIIHRDLK CDK4_Hsap DR-EIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLK CDK6_Hsap DR-ETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLK CDK4_Spur GRSEMMLTLVFELVDQDLAQYLEKCPPPGLSPCTIKFLMHQLLSGVEYLHSHRVTHRDLK : :::* : ** : . * *:. : : ::: .:::**:: : ***** Cdk4_Dmel PQNLLVSSQGHLKIADFGLAKTYGSEMKLTSVVVTLWYRAPEVLLAQPYNSTVDIWSAAC CDK6_Mmus PQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGC CDK4_Mmus PENILVTSNGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGC cdk-4_Cele PQNILLNRDQTVKLADFGLSKEYSNTTAFTTLVVTLWYRSPEVLLQSYYNSTVDMWALGC CDK4_Hsap PENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGC CDK6_Hsap PQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGC CDK4_Spur PQNILVASDKKLKLTDFGLSRVYSFQMALTPVVVTMWYRAPEVLLQASYATPVDMWSVGC *:*:*: :*::****:: *. :*.:***:***:***** * :.**:*: .* Cdk4_Dmel IIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKRPKDFCP CDK6_Mmus IFAEMFRRKPLFRGSSDVDQLGKILDIIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVT CDK4_Mmus IFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVSLPRGAFAPRGPRPVQSVVP cdk-4_Cele IVSEIYCRQPLFVGQNEAEQLTDIFKKMGTPVGKDWPSESVIARDSFPQYRPTNLKDLSP CDK4_Hsap IFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVP CDK6_Hsap IFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVT CDK4_Spur IFAELYRRRPLFRGQSDKDQLHKIFEVIGLPPEDQWP-DVALPWSSFRQTGQRSFLDLVQ *. *:: *:.** * .: :** *:. * * .:** :. * .. Cdk4_Dmel HLCKYADDLLNKMLSYDLHLRPSALACLEHDYFQQE------------------------ CDK6_Mmus DIDELGKDLLLKCLTFNPAKRISAYGALNHPYFQDLERYKDNL----------------- CDK4_Mmus EMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKEE----------------------- cdk-4_Cele QMSKQAIEFVQQCLRYDHSKRLSARGALSHPFLKPAVATKSRV----------------- CDK4_Hsap EMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE----------------------- CDK6_Hsap DIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENL----------------- CDK4_Spur EICNQGLDLLERMLCFNPDHRMTAEQGLLHGFFGDEEEDDEEDDDTEVEDDDDEEDEDDE .: : . ::: . * :: * :* * * :: Cdk4_Dmel --------------------------------------------PL CDK6_Mmus ------------------------------NSHLPSNQSTSELNTA CDK4_Mmus ------------------------------------------SDAE cdk-4_Cele ------------------------------L--------KQINFNK CDK4_Hsap ------------------------------------------GNPE CDK6_Hsap ------------------------------DSHLPPSQNTSELNTA CDK4_Spur GVDVSQEHSQSASTSSMSQATDDSGSHSQFFSDSSQSQDVTPTNKR