CLUSTAL W (1.83) multiple sequence alignment Cdk8_Dmel MQNVRAYPYQPATSNMNAYCLHNMQYQQQRLPFHQQQQQHHQQLQQQQSQFQPLRSHQLI CDK8_Mmus ------------------------------------------------------------ CDK19_Mmus ------------------------------------------------------------ F39H11.3_Cele MTLM-------------------------------------------------------- SSN3_Scer ------------------------------------------------------------ CDK19_Hsap ------------------------------------------------------------ CDK8_Hsap ------------------------------------------------------------ Cdk8_Ddis ------------------------------------------------------------ CDK8_Spur ------------------------------------------------------------ CC1G_07887_Ccin ------------------------------------------------------------ AqueK099_Aque ------------------------------------------------------------ CDK8_Smoe ------------------------------------------------------------ Cdk8_Dmel GGIFIYKQLWNLQTFVKMDYDFK------------------------------------- CDK8_Mmus -----------------MDYDFK------------------------------------- CDK19_Mmus -----------------MDYDFK------------------------------------- F39H11.3_Cele -----------------IDENFK------------------------------------- SSN3_Scer -----------------MYNGKDRAQNSYQPMYQRPMQVQGQQQAQSFVGKK--NTIGSV CDK19_Hsap -----------------MDYDFK------------------------------------- CDK8_Hsap -----------------MDYDFK------------------------------------- Cdk8_Ddis -----------------MNTHNQSS-------------------NQNGGGSGGGGGGGG- CDK8_Spur -----------------MDYEFK------------------------------------- CC1G_07887_Ccin -----------------MQQQQQQQ----------------------------------- AqueK099_Aque -----------------MDSGFI------------------------------------- CDK8_Smoe -----------------MADGI-------------------------------------- : Cdk8_Dmel --------------------MKTQIERTKVEDLFN---------------------YEGC CDK8_Mmus --------------------VKLSSERERVEDLFE---------------------YEGC CDK19_Mmus --------------------AKLAAERERVEDLFE---------------------YEGC F39H11.3_Cele --------------------KQLAQRRERVEDLFY---------------------FENS SSN3_Scer HGKAPMLMANNDVFTIGPY--RARKDRMRVSVLEK---------------------YEVI CDK19_Hsap --------------------AKLAAERERVEDLFE---------------------YEGC CDK8_Hsap --------------------VKLSSERERVEDLFE---------------------YEGC Cdk8_Ddis ----------S---STFSPIVLTSTYRLDVQEKYT---------------------F--S CDK8_Spur --------------------QQTSGVRESVEDLFD---------------------FEGC CC1G_07887_Ccin ---------------------QQVSLDEWVSNVMQHDPMRVYRARRDAHHRPVTSKYAIL AqueK099_Aque --------------------DALSQKREKVEDLFE---------------------YEGK CDK8_Smoe ------------------------AKRARPAWLQQ---------------------YELL : Cdk8_Dmel -KVGRGTYGHVYKAKWKET--S-D------------------------------------ CDK8_Mmus -KVGRGTYGHVYKAKRKDG--K-D------------------------------------ CDK19_Mmus -KVGRGTYGHVYKARRKDG--K-D------------------------------------ F39H11.3_Cele KEIGRGTYGLVYKAVPKKQNGQFP------------------------------------ SSN3_Scer GYIAAGTYGKVYKAKRQINSGTNSANGSSLNGTNAKIPQFDSTQPKSSSSMDMQANTNAL CDK19_Hsap -KVGRGTYGHVYKARRKDG--K-D------------------------------------ CDK8_Hsap -KVGRGTYGHVYKAKRKDG--K-D------------------------------------ Cdk8_Ddis YEIGSGTYGMVYKADDKKRPN--------------------------------------- CDK8_Spur -KVGRGTYGHVYKATTKKE----P------------------------------------ CC1G_07887_Ccin GFISSGTYGRVYKAQSINGG-E-------------------------------------- AqueK099_Aque -KIGRGTYGHVYKAKKRSG--D-D------------------------------------ CDK8_Smoe GKIGEGTYGLVYLAKSKLVSN--R------------------------------------ :. **** ** * Cdk8_Dmel --------------------------------------GKEYALKQ----------IDGT CDK8_Mmus --------------------------------------DKDYALKQ----------IEGT CDK19_Mmus --------------------------------------EKEYALKQ----------IEGT F39H11.3_Cele --------------------------------------NKEYALKM----------IEGQ SSN3_Scer RRNLLKDEGVTPGRIRTTREDVSPHYNSQKQTLIKKPLTVFYAIKKFKTEKDGVEQLHYT CDK19_Hsap --------------------------------------EKEYALKQ----------IEGT CDK8_Hsap --------------------------------------DKDYALKQ----------IEGT Cdk8_Ddis ---------------------------------------NKVAVKKFRS------TKEGE CDK8_Spur --------------------------------------KKEYALKQ----------IEGT CC1G_07887_Ccin ----------------------------------------LLAIKKFKPDKEG-DVVTYT AqueK099_Aque --------------------------------------PKEYALKQ----------IEGT CDK8_Smoe --------------------------------------GVKIAIKKFKQ------SKEGD *:* Cdk8_Dmel GLSMSACREIALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKAT CDK8_Mmus GISMSACREIALLRELKHPNVISLLKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKAN CDK19_Mmus GISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKAN F39H11.3_Cele GFSMSACREIALFRELRHPNLICLQRVFLTN-EKKVWLLLDYAEHDLWHVIKHHRTAKSK SSN3_Scer GISQSACREMALCRELHNKHLTTLVEIFLE--RKCVHMVYEYAEHDLLQIIHFHSHPE-- CDK19_Hsap GISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKAN CDK8_Hsap GISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKAN Cdk8_Ddis GLSLTAYREIGLLKELSNENIVKLLDVCLNPKDKLLYLIFDYAEFDLFGIIKYHRENG-- CDK8_Spur GISMSACREVALLRELRHPNVICLRRVFLSHSDRKVYLLCDFSEHDLWHIIKYHRANKAS CC1G_07887_Ccin GISQSAIREIALNREINHENVVALREVILE--DKSIYMVFEYAEHDFLQVIHHYYQTI-- AqueK099_Aque GISMSACREIALLRELKHSNVISLQRVFLSHADRKVWLLFDYAEHDLWHIIKYHRAVKGG CDK8_Smoe GVSPTAIREIMLLRECMHENVVKLVDVHINHADMSLYLAFEYAEHDLYEIIRHHREKL-- *.* :* **: * :* : :: * : : : : :::*.*: :*:.: Cdk8_Dmel KK-QVVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMG--------------- CDK8_Mmus KKP-VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMG--------------- CDK19_Mmus KKP-MQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMG--------------- F39H11.3_Cele KVP-IMVPRNMVKNILFQILSGMHYLHSNWVLHRDLKPANILLMG--------------- SSN3_Scer ---KRMIPPRMVRSIMWQLLDGVSYLHQNWVLHRDLKPANIMVTI--------------- CDK19_Hsap KKP-MQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMG--------------- CDK8_Hsap KKP-VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMG--------------- Cdk8_Ddis ----SHFSDATIKSLIWQVLNGIHYLHSNWVIHRDLKPSNILVMG--------------- CDK8_Spur KKGPTSVPPVMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGF CC1G_07887_Ccin ---RTSIPTAVLKSLIYQLFNGLIYLHASHILHRDLKPANILITS--------------- AqueK099_Aque KKPQVQVPKTMVKSLMYQILSGIHYLHSNWVLHRDLKPANILVMG--------------- CDK8_Smoe ---LFQINPYTVKSLLWQILNGINYLHSNWIIHRDLKPSNILVMGV-------------- . ::.:::*::.*: *** . ::******:**:: Cdk8_Dmel ------------------------------------------------------------ CDK8_Mmus ------------------------------------------------------------ CDK19_Mmus ------------------------------------------------------------ F39H11.3_Cele ------------------------------------------------------------ SSN3_Scer ------------------------------------------------------------ CDK19_Hsap ------------------------------------------------------------ CDK8_Hsap ------------------------------------------------------------ Cdk8_Ddis ------------------------------------------------------------ CDK8_Spur ARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHC CC1G_07887_Ccin ------------------------------------------------------------ AqueK099_Aque ------------------------------------------------------------ CDK8_Smoe ------------------------------------------------------------ Cdk8_Dmel ------------------------------------------------------------ CDK8_Mmus ------------------------------------------------------------ CDK19_Mmus ------------------------------------------------------------ F39H11.3_Cele ------------------------------------------------------------ SSN3_Scer ------------------------------------------------------------ CDK19_Hsap ------------------------------------------------------------ CDK8_Hsap ------------------------------------------------------------ Cdk8_Ddis ------------------------------------------------------------ CDK8_Spur RQEDIKTSNPYHHDQLDRIFNVMGFPQVPPVMVKSLLYQILDGIHYLHSNWVLHRDLKPA CC1G_07887_Ccin ------------------------------------------------------------ AqueK099_Aque ------------------------------------------------------------ CDK8_Smoe ------------------------------------------------------------ Cdk8_Dmel ------DGN--ERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTK CDK8_Mmus ------EGP--ERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTK CDK19_Mmus ------EGP--ERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTK F39H11.3_Cele ------DGPPDMRGRVKIADLGFSRIYANPLKPMAELDPVVVTFWYRAPELLLGAKHYTK SSN3_Scer ------D------GCVKIGDLGLARKFHNMLQTLYTGDKVVVTIWYRAPELLLGARHYTP CDK19_Hsap ------EGP--ERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTK CDK8_Hsap ------EGP--ERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTK Cdk8_Ddis ------EGK--ECGTVKIGDFGLARIFQSPLKPLNE-NGVVVTIWYRSPELLLGSKHYTR CDK8_Spur NILVMGEGS--ERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTK CC1G_07887_Ccin ------Q------GVVKIGDLGLARLCYEPLQPLFAGDKVVVTIWYRAPELLMGAKHYNK AqueK099_Aque ------DGP--ERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGAKHYTK CDK8_Smoe ----SGDGD--EQGLVKIGDFGLARIYQAPLKPLSD-NGVVVTIWYRAPELLLGAKHYTC : * ***.*:*::* *:.: : ****:***:****:*::**. Cdk8_Dmel AIDIWAIGCIFAELLTSEPIFHCRQE--DIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIK CDK8_Mmus AIDIWAIGCIFAELLTSEPIFHCRQE--DIKTSNPYHHDQLDRIFNVMGFPADKDWEDIK CDK19_Mmus AIDIWAIGCIFAELLTSEPIFHCRQE--DIKTSNPFHHDQLDRIFSVMGFPADKDWEDIR F39H11.3_Cele AIDVWAIGCIFAELLTAEPLFFCKEE--DIKAQNPYHYDQVKRIFHLLGYPSDADWPDMK SSN3_Scer AVDLWSVGCIFAELIGLQPIFKGEEAKLDSKKTVPFQVNQLQRILEVLGTPDQKIWPYLE CDK19_Hsap AIDIWAIGCIFAELLTSEPIFHCRQE--DIKTSNPFHHDQLDRIFSVMGFPADKDWEDIR CDK8_Hsap AIDIWAIGCIFAELLTSEPIFHCRQE--DIKTSNPYHHDQLDRIFNVMGFPADKDWEDIK Cdk8_Ddis AVDIWAIGCIFAELITTKPLFPGKEK--DPKIPSLFQDDQVEKIIRVLGKPTLDMWPDIK CDK8_Spur AIDIWAIGCIFAELLTSEPIFHCRQE--DIKTSNPYHHDQLDRIFNVMGFPQEKDWEDIK CC1G_07887_Ccin AIDCWAVGCVMAELASLRPIFKGEEAKLDSKKNVPFQRDQLIKIFEVLGTPDERDWPGVV AqueK099_Aque AIDIWAIGCIFAELLTFEPIFHCRQE--DVEASSPYHREQLERIFLVMGFPH-------- CDK8_Smoe AVDMWAVGCIFAELLTLKPLFQGA-E--DKTGPNPFQLDQLDKIFKVLGHPTTERWPMLS *:* *::**::*** .*:* * :: :*: :*: ::* * Cdk8_Dmel KMPEHHTLTKDFKRS-----TYSTCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRITS CDK8_Mmus KMPEHSTLMKDFRRN-----TYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITS CDK19_Mmus KMPEYPTLQKDFRRT-----TYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITS F39H11.3_Cele KMPDHQRLLSDARNEGTPIQTFPN-SLHRYFDKWKINSQSSPYRLLVKLLTVDPTKRVSC SSN3_Scer KYPEYDQITKFP--------KYRD-NLATWYH-SAGGRDKHALSLLYHLLNYDPIKRIDA CDK19_Hsap KMPEYPTLQKDFRRT-----TYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITS CDK8_Hsap KMPEHSTLMKDFRRN-----TYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITS Cdk8_Ddis HLPEWKRLSSM---E-----AFPN-SLAKC---VGIDENSQAYDLLSKMILYDPSKRITA CDK8_Spur KMPEHGNLMKDFRRS-----NYASCCLPKYMEKHKVPKDSKAFQLLSKLLTMDPTKRMTS CC1G_07887_Ccin DMPEYRNMKLLD--------HFSN-RLSDWCH--TRIRSPQGYDLLRQLFAYDPDNRLTA AqueK099_Aque ------------------------------------------------------------ CDK8_Smoe NLPHWLANRQLIQSR-----KYDNPGLHTV---VNLQPKGLAFDLLSRMLEYDPVKRITA Cdk8_Dmel EQAMQDQYFQEEP---QPTQ-DVFAGC-----PIPYPKREF------------------L CDK8_Mmus EQAMQDPYFLEDP---LPTS-DVFAGC-----QIPYPKREF------------------L CDK19_Mmus EQALQDPYFQEDP---LPTL-DVFAGC-----QIPYPKREF------------------L F39H11.3_Cele EEAMNDIYFRKMERPPRETD-DVFNKY-----PIPYAKKEQQMTVRASIVEYTANVPKIL SSN3_Scer FNALEHKYFTESD---IPVSENVFEGL-----TYKYPARRI------------------H CDK19_Hsap EQALQDPYFQEDP---LPTL-DVFAGC-----QIPYPKREF------------------L CDK8_Hsap EQAMQDPYFLEDP---LPTS-DVFAGC-----QIPYPKREF------------------L Cdk8_Ddis SEALDHPYFKELP---LPLP-NAFS-K-----PIPYPPRLP------------------I CDK8_Spur EQAMEDQYFKEQP---QHTA-DVFDGK-----PIPYPKREF------------------L CC1G_07887_Ccin EQAIQHKWFHEDP---LPTW-NAFQSL-A-QHQIP-PCRRI------------------T AqueK099_Aque ------------------------------------------------------------ CDK8_Smoe AQALDHEYFRSDP---LPGR-NALVYGQPGEKVVQYPARPV------------------D Cdk8_Dmel TDDDQ-EDKSDNKRQQ--QQQQQQQQQQ--QQ-----QQQQQQQQQ-----QQ-Q----- CDK8_Mmus TEEEP-DEKGDKKTQQ--QQQGNNH-------------------------TNGT------ CDK19_Mmus NEDEP-EEKGDKNQPQ--QQNPHQQPAA--PAQQTAAPPQAPPPQQSSAQTNGTAGGATA F39H11.3_Cele LQVAP-DQAQQQHQQQ--QVQMQQQPQM--GQQQMMGQPQMVQPQMGQPPMGGAHPGVVA SSN3_Scer TNDNDIMNLGSRTKNNT-QAS--GI-------------------------TA---GAAAN CDK19_Hsap NEDDP-EEKGDKNQQQ--QQNQHQQPTA--PPQQAAAPPQAPPPQQNSTQTNGTAGGAGA CDK8_Hsap TEEEP-DDKGDKKNQQ--QQQGNNH-------------------------TNGT------ Cdk8_Ddis NKKK-------------------------------------------------------- CDK8_Spur TDDDN-DDKSDNNKKS--SSSRNSSHMVDARRQRVA-TSMAGSTSQ-----QGSVGGTRT CC1G_07887_Ccin QDEA-PSMMPMATQQNTQQAMGGGH-------------------------IA---GGAGA AqueK099_Aque ------------------------------------------------------------ CDK8_Smoe SSTDF-EGSGSIQNTQ--MVRNRKRKQA--FF-----SP----------LQC---GGGSS Cdk8_Dmel --------------Q--------------------------------QMNAEPNAKRVRL CDK8_Mmus -------GHPGNQDS--------------------------------GHAQGPPLKKVRV CDK19_Mmus GGGGAGAGLQHSQDP--------------------------------GLNQVPPNKKPRI F39H11.3_Cele PDGHPHQMMQQQQHPQQHHVSFLNIQNEKLTFSVQMQYQGMHDPMQGGMDEGPQAKMMRM SSN3_Scer ALGGLG------------------------------------------------VNR-RI CDK19_Hsap GVGGTGAGLQHSQDS--------------------------------SLNQVPPNKKPRL CDK8_Hsap -------GHPGNQDS--------------------------------SHTQGPPLKKVRV Cdk8_Ddis ------------------------------------------------------------ CDK8_Spur -------GGS----S--------------------------------SHAQG--AKRLRV CC1G_07887_Ccin PFSKPG----------------------------------------------------ST AqueK099_Aque ------------------------------------------------------------ CDK8_Smoe FLM-----------V--------------------------------STFRGSQMSTSNS Cdk8_Dmel SGA------------GNQ-----QDFHHQ-----------------------Q------- CDK8_Mmus VPPTTTSGG----------LIMTSDYQRS-----------------------NPHAAYPN CDK19_Mmus GPSGANSGG----------PVMPSDYQHS-----------------------SSRLNYQS F39H11.3_Cele GNVPVGRYAPMPPPYGAP-----QDYHPQQGPPMVQMMQQPGPSGYYPQRPGQPTGAVPG SSN3_Scer LAAAAAAAA--------------------------------------------------- CDK19_Hsap GPSGANSGG----------PVMPSDYQHS-----------------------SSRLNYQS CDK8_Hsap VPPTTTSGG----------LIMTSDYQRS-----------------------NPHAAYPN Cdk8_Ddis ------------------------------------------------------------ CDK8_Spur ATTNSSSHG------GAQAGIMPQEYQQQ-----------------------QRMSGYQG CC1G_07887_Ccin ASFASLSGG--------------------------------------------------- AqueK099_Aque ------------------------------------------------------------ CDK8_Smoe LPASAASAA------A---ASATANAVRP-----------------------MHHQQMPL Cdk8_Dmel ------Q----------------------------------------------------- CDK8_Mmus P--GPST-SQ-----------------------------PQSSMGYSA------------ CDK19_Mmus S--VQGS-SQ-----------------------------SQSTLGYSS------------ F39H11.3_Cele P--GPQGYMN----PQMGMQMGMRAPGVPPQGYMPGRGMAPPQMGQQQ------------ SSN3_Scer ----------------------------------------------AV------------ CDK19_Hsap S--VQGS-SQ-----------------------------SQSTLGYSS------------ CDK8_Hsap P--GPST-SQ-----------------------------PQSSMGYSA------------ Cdk8_Ddis ------------------------------------------------------------ CDK8_Spur ANTTQGQ-SQ--------------------------NNKPQQGMMYSSSGSHHSNKMQHG CC1G_07887_Ccin ----------------------------------------------GP------------ AqueK099_Aque ------------------------------------------------------------ CDK8_Smoe V--GMQR-LQTASMGAFNVGAQPAMAGLAANMFVQRGQQLQQVAHHQQQ----------- Cdk8_Dmel --------QQQQ---------------QQQQQQQQQQQMMFNQQQNFQRFN CDK8_Mmus -------------------------------TSQQPPQ---Y--SHQTHRY CDK19_Mmus --------------------------------SQQSTQ---YHSSHQTHRY F39H11.3_Cele -----------------------------PGPNQQQQQ---Q--WQQQYHR SSN3_Scer -----------------------------SGNN------ASDEPSRKKNRR CDK19_Hsap -------------------------------SSQQSSQ---YHPSHQAHRY CDK8_Hsap -------------------------------TSQQPPQ---Y--SHQTHRY Cdk8_Ddis ----------------------------------------------REFDD CDK8_Spur QHHHHQQQQQQQQQQQHHQQHHQQQQQHQQQQQQQQQQHHQGHNQNQPRHY CC1G_07887_Ccin -----------------------------YAQSQGGTGGHTAHTRKKARMG AqueK099_Aque --------------------------------------------------X CDK8_Smoe --------QQQQ---------------QQQQHQHHQHQQHQVQKLRSFLRS