CLUSTAL W (1.83) multiple sequence alignment dco_Dmel ------------------------------------------------------------ F46F2.2_Cele MSNDAAAAATWHNNTSTPMDTTEPATNSHNPGETAVIGGPEALLLPSGSGPEEMNRHPLL HRR25_Scer ------------------------------------------------------------ CK1_Ddis ------------------------------------------------------------ CK1_C2d_Ddis ------------------------------------------------------------ CK1d_Spur ------------------------------------------------------------ CK1d_Mmus ------------------------------------------------------------ CK1e_Mmus ------------------------------------------------------------ CK1d_Hsap ------------------------------------------------------------ CK1e_Hsap ------------------------------------------------------------ CC1G_04803_Ccin ------------------------------------------------------------ CC1G_06627_Ccin MAESA------------------------------------------------------- AqueK089_Aque MNCGLC------------------------------ISGKESF----------------- GK019_Glam ------------------------------------------------------------ dco_Dmel ------------------------------------------------------------ F46F2.2_Cele MAQAHGEHHQPRLLHNFPVIPPPIQQHQQPPLLQQAQPSQIPHPTQPQIDPTMFTQQSGF HRR25_Scer ------------------------------------------------------------ CK1_Ddis ------------------------------------------------------------ CK1_C2d_Ddis ------------------------------------------------------------ CK1d_Spur ------------------------------------------------------------ CK1d_Mmus ------------------------------------------------------------ CK1e_Mmus ------------------------------------------------------------ CK1d_Hsap ------------------------------------------------------------ CK1e_Hsap ------------------------------------------------------------ CC1G_04803_Ccin ------------------------------------------------------------ CC1G_06627_Ccin ------------------------------------------------------------ AqueK089_Aque ----------------FPLFP--------------------------------------- GK019_Glam ------------------------------------------------------------ dco_Dmel -----------------------------------------------------------M F46F2.2_Cele NWPPIDPNTIAALAQAQLASSHAQFVSLALTLDPTLLSHFLATQQIPPVPQPLVHKKAEM HRR25_Scer -----------------------------------------------------------M CK1_Ddis -----------------------------------------------------------M CK1_C2d_Ddis -----------------------------------------------------------M CK1d_Spur -----------------------------------------------------------M CK1d_Mmus -----------------------------------------------------------M CK1e_Mmus -----------------------------------------------------------M CK1d_Hsap -----------------------------------------------------------M CK1e_Hsap -----------------------------------------------------------M CC1G_04803_Ccin -----------------------------------------------------------M CC1G_06627_Ccin ---------------------------------------------------------HRL AqueK089_Aque -----------------LSSNRSSFVSPSQTG--------------------WCLPLIKM GK019_Glam -----------------------------------------------------------M : dco_Dmel -ELR-VGNKYRLGRKIGSGSFGDIYLGTTINTGEEVAIKLECIRTKH----P-QLHIESK F46F2.2_Cele -ELR-VGNRFRLGRKIGSGSFGDIYLGQNIQTNEEVAVKLECVKSKH----P-QLHIESR HRR25_Scer -DLR-VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIKLESIRSRH----P-QLDYESR CK1_Ddis -DLR-IGGKYRISRKIGGGSFGEIYLGTNISTNEEVAIKLEPAKAIH----P-QLLFESK CK1_C2d_Ddis -DLR-IGGKYRISRKIGGGSFGEIYLGTNISTNEEVAIKLEPAKAIH----P-QLLFESK CK1d_Spur -ELR-VGNKYRLGRKIGSGSFGDIYLGTNITNGEEVAIKLECLKTKH----P-QLHIESK CK1d_Mmus -ELR-VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKH----P-QLHIESK CK1e_Mmus -ELR-VGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKH----P-QLHIESK CK1d_Hsap -ELR-VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKH----P-QLHIESK CK1e_Hsap -ELR-VGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKH----P-QLHIESK CC1G_04803_Ccin -VLTTYAGKYRFEEEIANGGCGTVFLGVHTTAGKQVAIKLEPTHPDHHPSHPSPLKTESK CC1G_06627_Ccin -DLR-VGGKYRLGKKIGSGSFGDIYLGINIISGEEVAIKLESVKAKH----P-QLEYESK AqueK089_Aque -ELR-VGGKYRLGRKIGSGSFGDIYLGTNIATKEEVAIKLECVKTKH----P-QLHIEAK GK019_Glam TDLR-IAGKYQLHYRIGRGAFGELYRGVNLATGEDVAIKLEPIDAKP----P-QLLYESK * . :::: .*. *. * :: * ::**:*** . * * *:: dco_Dmel FYKTMQGGIGIPRIIWCGSEGDYNVMVMELLGPSLEDLFNFCSRRFSLKTVLLLADQMIS F46F2.2_Cele LYRIMLGGIGIPEIRWCGQEGDYNVMVMELLGPSLEDLFNFCQRKFSLKTVLLLADQMLS HRR25_Scer VYRYLSGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFC CK1_Ddis LYKIFQGGIGIPAVKWFGFDGDYNIMVMDLLGPSLEDLFNYCGRKFSLKTVLMLGDQMLR CK1_C2d_Ddis LYKIFQGGIGIPAVKWFGFDGDYNIMVMDLLGPSLEDLFNYCGRKFSLKTVLMLGDQMLR CK1d_Spur FYKMMQGGVGIPTVKWCGAEGDYNVMVMELLGPSLEDLFNFCSREFSLKTVLLLADQLIS CK1d_Mmus IYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMIS CK1e_Mmus FYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMIS CK1d_Hsap IYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMIS CK1e_Hsap FYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMIS CC1G_04803_Ccin IYKSLSGGEGVPWIIWSGRQGDYNVMVTDLLGPSLEDLFKMCNRHFSMKTVLLLADQLIS CC1G_06627_Ccin VYKTLAGGVGVPFVRWFGTECDYNAMVLDLLGPSLEDLFNFCNRKFSLKTVLLLADQLIS AqueK089_Aque FYKMMQSGVGIPSIKWCGTEGDYNVLVMELLGPSLEDLFNFCSRKFSLKTVLLLADQLIN GK019_Glam LYKILVGGVGIPYIYHYAPEGEYNVLVMDLLGPSLEDLFTACNRHFSLKTVLMLADQMIT .*: : .* *:* : . : :** :* :**********. * *.**:***::*. *:: dco_Dmel RIDYIHSRDFIHRDIKPDNFLMGLGKK--------------------------------- F46F2.2_Cele RVEFIHCRDYIHRDIKPDNFLMGLGKR--------------------------------- HRR25_Scer RIQYIHGRSFIHRDIKPDNFLMGVGRR--------------------------------- CK1_Ddis RIEFIHSNNFIHRDIKPDNFLMGIGKR--------------------------------- CK1_C2d_Ddis RIEFIHSNNFIHRDIKPDNFLMGIGKR--------------------------------- CK1d_Spur RIEYVHSKNFIHRDIKPDNFLMGLGKK--------------------------------- CK1d_Mmus RIEYIHSKNFIHRDVKPDNFLMGLGKK--------------------------------- CK1e_Mmus RIEYIHSKNFIHRDVKPDNFLMGLGKK--------------------------------- CK1d_Hsap RIEYIHSKNFIHRDVKPDNFLMGLGKK--------------------------------- CK1e_Hsap RIEYIHSKNFIHRDVKPDNFLMGLGKK--------------------------------- CC1G_04803_Ccin RIEFVHSHSIVHRDIKPANFVMSVAPQTPCSCSTSHSNANSTAPSPTSPSSSLPDPVEGD CC1G_06627_Ccin RIEYIHSRNFIHRDIKPDNFLMGIGKR--------------------------------- AqueK089_Aque RIEYIHSKNFIHRDVKPDNFLMGLGKK--------------------------------- GK019_Glam RVEFLHLKNFLHRDIKPDNFLIGLGRR--------------------------------- *::::* .. :***:** **::.:. : dco_Dmel ---------------------GNLVYIIDFGLAKKFRDARSLKHIPYRENKN---LTGTA F46F2.2_Cele ---------------------GNLVYIIDFGLAKRYRDSK-HQHIAYRENKN---LTGTA HRR25_Scer ---------------------GSTVHVIDFGLSKKYRDFNTHRHIPYRENKS---LTGTA CK1_Ddis ---------------------GHVVNLIDFGLAKRYRDPKTHQHIPYREHKN---LTGTA CK1_C2d_Ddis ---------------------GHVVNLIDFGLAKRYRDPKTHQHIPYREHKN---LTGTA CK1d_Spur ---------------------GNMVYIIDFGLAKRYKDPRTKLHIAYRENKN---LTGTA CK1d_Mmus ---------------------GNLVYIIDFGLAKKYRDARTHQHIPYRENKN---LTGTA CK1e_Mmus ---------------------GNLVYIIDFGLAKKYRDARTHQHIPYRENKN---LTGTA CK1d_Hsap ---------------------GNLVYIIDFGLAKKYRDARTHQHIPYRENKN---LTGTA CK1e_Hsap ---------------------GNLVYIIDFGLAKKYRDARTHQHIPYRENKN---LTGTA CC1G_04803_Ccin VVKPVRSRLPSPPASSRPCPHHPLVHIIDFGLAKKFRDSVSQIHIPFSQHPTGLHGVGTS CC1G_06627_Ccin ---------------------GNQVNVIDFGLAKKFRDPKTHLHIPYRENKN---LTGTA AqueK089_Aque ---------------------GNLVYIIDFGLAKKYRDTRTHQHIPYRENKN---LTGTA GK019_Glam ---------------------KTTVYIIDFGLAKRYMVGNT--HIPYREHKS---LTGTA * :*****:*:: **.: :: . .**: dco_Dmel RYASINTHLGIEQSRRDDLESLGYVLMYFNLGALPWQGLKAANKR--------------- F46F2.2_Cele RYASINTHRGIEQSRRDDIESLGYVFMYFNRGTLPWQGLKAVTKR--------------- HRR25_Scer RYASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKK--------------- CK1_Ddis RYASLNTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAYTKR--------------- CK1_C2d_Ddis RYASLNTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAYTKR--------------- CK1d_Spur RYASINTHLGIEQSRRDDLESLGYMLMYFNRGSLPWQGLKAATKK--------------- CK1d_Mmus RYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKR--------------- CK1e_Mmus RYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKR--------------- CK1d_Hsap RYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKR--------------- CK1e_Hsap RYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKR--------------- CC1G_04803_Ccin LFASINTHLGMEASRRDDLESLAYMLIYFLRGTLPWRKMRAPSNLPSSILAAISNSEERR CC1G_06627_Ccin RYTSINTHLGVEQARRDDLESLAYVLMYFLRGALPWQGLKAATKK--------------- AqueK089_Aque RYASINTHLGIEQSRRDDLESLGYMLMYFNLGNLPWQGLKAATKK--------------- GK019_Glam RYCSINTHLGLEQSRRDDLEALAYVFLYFLRGFLPWQGLKANTKR--------------- : *:*** *:* :****:*:*.*:::** * ***: ::* .: dco_Dmel ----------QKYERISEKKLSTSIVVLCKGFPSEFVNYLNFCRQMHFDQRPDYCHLRKL F46F2.2_Cele ----------QKYELISEKKISTRVDDLCAGYPEAFAQYLNYCRSLGFEEQPDYGYLRNL HRR25_Scer ----------QKYDRIMEKKLNVSVETLCSGLPLEFQEYMAYCKNLKFDEKPDYLFLARL CK1_Ddis ----------DKYEKICDKKAQTKIDTLCQGFPSEFATFLNYTRFLKFEDKPDFLYLRKL CK1_C2d_Ddis ----------DKYEKICDKKAQTKIDTLCQGFPSEFATFLNYTRFLKFEDKPDFLYLRKL CK1d_Spur ----------QKYEKISEKKMSTPIEVLCKGYSPEFATYLNHTRNLRFDEKPDYSFLRQL CK1d_Mmus ----------QKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQL CK1e_Mmus ----------QKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQL CK1d_Hsap ----------QKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQL CK1e_Hsap ----------QKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQL CC1G_04803_Ccin EAQEHYNPVSATWDLIRDSKLEHE-ATLTEGLPEEFHVLYTYARNLEFDDLPDYEGLRNC CC1G_06627_Ccin ----------QKYDRIMEKKMTTPTDLLCRGFPNEFGIFLNYTRALRFDDKPDYSYLRKL AqueK089_Aque ----------QKYEKISEKKLSTPVEVLCRGYPGEFATYLNFCRGLKFEDKPDYTYLRQL GK019_Glam ----------QKYEKILEKKLSSPIESLTRGQPTEFAAYLHYTRALRFDDRPDYAYLRKI .:: * :.* * * . * . : : *:: **: * . dco_Dmel FRNLFHRLGFTYDYVFDWNLLKFGGPRN----P--------------------------- F46F2.2_Cele FRTLFHRQQFCYDYVFDWNTYNKRYQIN-------------------------------- HRR25_Scer FKDLSIKLEYHNDHLFDWTMLRYTKAMVEKQRDL---LIEK--GDL-NANSNAASASNST CK1_Ddis LREMFVREGYRYDYMFDWVIVRKLREKPPLERPL------------------------SN CK1_C2d_Ddis LREMFVREGYRYDYMFDWVIVRKLREKPPLERPL------------------------SN CK1d_Spur FRNLFHRLGYTYDYVFDWNMLKFSDVPGRGGKP--------------------------H CK1d_Mmus FRNLFHRQGFSYDYVFDWNMLKFGASRA----A--------------------------- CK1e_Mmus FRNLFHRQGFSYDYVFDWNMLKFGAARN----P--------------------------- CK1d_Hsap FRNLFHRQGFSYDYVFDWNMLKFGASRA----A--------------------------- CK1e_Hsap FRNLFHRQGFSYDYVFDWNMLKFGAARN----P--------------------------- CC1G_04803_Ccin FRGLAARLGIEYDGVFDWSVKGPGEGGSKG--P--------------------------- CC1G_06627_Ccin FRDLFVREGYQYDYVFDWSVQRGAQEDQAA------------------------SSSKVP AqueK089_Aque FRNLFHRLGYTYDYVFDWNTAGIPTSDH----M--------------------------- GK019_Glam FRELFVREGFSYDYVFDWTLLGIDVDKYHENKLRGKELNPNADGKKKGSDSGAENGDDDA :: : : * :*** dco_Dmel QAI--------------------------------------------------------- F46F2.2_Cele --V--------------------------------------------------------- HRR25_Scer DNK--------------------------------------------------------- CK1_Ddis DNK--------------------------------------------------------- CK1_C2d_Ddis DNK--------------------------------------------------------- CK1d_Spur PTK--------------------------------------------------------- CK1d_Mmus DDA--------------------------------------------------------- CK1e_Mmus EDV--------------------------------------------------------- CK1d_Hsap DDA--------------------------------------------------------- CK1e_Hsap EDV--------------------------------------------------------- CC1G_04803_Ccin GIA--------------------------------------------------------- CC1G_06627_Ccin ------------------------------------------------------------ AqueK089_Aque SSAPSHGMAVGYRDGLHPSSGPLQYSHMATPSSRQAIATTTPMSRPHPTMTSPMHPSNFN GK019_Glam DDK--------------------------------------------------------- dco_Dmel --------------Q-------------------------QAQDGADGQAGHDAVAAAAA F46F2.2_Cele --------------D-------------------------INCIIS-------------- HRR25_Scer --------------SETFNKIKLLAMKKFPTHFHYYKNEDKHNPSPEE------------ CK1_Ddis --------------Q-------------------------IQQQIQQQ------------ CK1_C2d_Ddis --------------Q-------------------------IQQQIQQQ------------ CK1d_Spur --------------E-------------------------AERRDREE------------ CK1d_Mmus --------------E-------------------------RERRD--R------------ CK1e_Mmus --------------D-------------------------RERREHER------------ CK1d_Hsap --------------E-------------------------RERRD--R------------ CK1e_Hsap --------------D-------------------------RERREHER------------ CC1G_04803_Ccin --------------S-------------------------KKIR-RGR------------ CC1G_06627_Ccin ------------------------------------------------------------ AqueK089_Aque DNTECARTIVPMMRT-------------------------RSRSD--K------------ GK019_Glam --------------D------------------------DKD----DK------------ dco_Dmel VAAAAAASSHQQQQHKVNAALGGGGGS-----------AA--QQQLQGG---Q------T F46F2.2_Cele ---------FSSLCSISSLISHFLPPFC------DT------------------------ HRR25_Scer ---------IKQQTILNNNAASSLPEEL------LNA-LDKGMENLRQQQPQQ------Q CK1_Ddis ---------QQAQQQLQQQAQQQQQQT---------T--T--TTTTSS----S------Q CK1_C2d_Ddis ---------QQAQQQLQQQAQQQQQQT---------T--T--TTTTSS----S------Q CK1d_Spur ---------HERHHHPRSSTTRALAGT-----------AA--TVRLRNQ---E------P CK1d_Mmus ---------EERLRHSRNPATRGLPST------------A--SGRLRGT---Q------E CK1e_Mmus ---------EERMGQLRGSATRALPPGP------PTG-AT--ANRLRSA---A------E CK1d_Hsap ---------EERLRHSRNPATRGLPST------------A--SGRLRGT---Q------E CK1e_Hsap ---------EERMGQLRGSATRALPPGP------PTG-AT--ANRLRSA---A------E CC1G_04803_Ccin ---------QCL------------------------------------------------ CC1G_06627_Ccin ----------------------------------------VGRRKVVQE----------- AqueK089_Aque ---------EKQGITGHSSGAGGMPSSMLQASGGAVGGLS--DDRLVGS---MDYHHSHH GK019_Glam ---------GEK---------------------------------KKKDKDKD------- dco_Dmel LAML--GGNGGGNGSQLIGGNGL------NMDDSMAATNSSRPP------------YD-- F46F2.2_Cele -----------------------------I-HVSFASSFSPPSCLFFSSVFFCCFLKN-- HRR25_Scer VQSSQPQ--------------PQPQQLQQQ-PNGQRPNYYPEPL------------LQQQ CK1_Ddis PSNV--K--------------NI------S-TVSNIAT------------------TT-- CK1_C2d_Ddis PSNV--K--------------NI------S-TVSNIAT------------------TT-- CK1d_Spur AAVV--N--------------PV--------AVGGFHATSPRPV------------SR-- CK1d_Mmus VAPP--T--------------PL------T-PTSHTANTSPRPV------------SG-- CK1e_Mmus PVAS--T--------------PA------S-RIQQTGNTSPRAI------------SR-- CK1d_Hsap VAPP--T--------------PL------T-PTSHTANTSPRPV------------SG-- CK1e_Hsap PVAS--T--------------PA------S-RIQPAGNTSPRAI------------SR-- CC1G_04803_Ccin -------------------------------------ACDARAK------------A--- CC1G_06627_Ccin ------------------------------------------------------------ AqueK089_Aque VQPP--P--------------PQ------P-EF-----LHPSPM---------ERMTT-- GK019_Glam ------------------------------------------------------------ dco_Dmel -----TPERRPS--IRMRQGG--GGGGGG----------------------VGVGGM--- F46F2.2_Cele ----NNNNNNLFLVFHLQRFL--PFL--S---------VHFPRSV--------------- HRR25_Scer QRDSQEQQQQVP--MATTRATQYPPQINSNNFNTNQASVPPQMRSNP--Q---------- CK1_Ddis ----TDEQ--FR---QLLSTP--SYNNVDSDQSPQQTTTTTSSSN-P--NQTTFYRQNKV CK1_C2d_Ddis ----TDEQ--FR---QLLSTP--SYNNVDSDQSPQQTTTTTSSSN-P--NQTTFYRQNKV CK1d_Spur ----AEQQRTNN--RRLVRGL--ATGPPSSDPVQRGDYGRLATPYSAFNG-ATSTGMKSA CK1d_Mmus ----MERERKVS--MRLHRGA--PVNVSSSDLTGRQDTSRMSTSQIP--G---------- CK1e_Mmus ----ADRERKVS--MRLHRGA--PANVSSSDLTGRQEVSRLAAS---------------- CK1d_Hsap ----MERERKVS--MRLHRGA--PVNISSSDLTGRQDTSRMSTSQIP--G---------- CK1e_Hsap ----VDRERKVS--MRLHRGA--PANVSSSDLTGRQEVSRIPAS---------------- CC1G_04803_Ccin ------------------------------------------------------------ CC1G_06627_Ccin ----ADEDHRAS--DRMLRSH--TRQAQ-----QAGGSGMPQAR---------------- AqueK089_Aque ----RSHARQLX--XXXTRSH--ARQLRSSSRPSDKDLRDPATAQNT--Q---------- GK019_Glam DDDSEDGAKRSE--RRSRRGS--M-------RGEDHSTKDEKRKKTD--S---------- dco_Dmel --PSGGGGGGVGNAK F46F2.2_Cele IDLCLSFFGCIFLLF HRR25_Scer -QPPQDKPAGQSIWL CK1_Ddis VVPQSSSTTTKPPAK CK1_C2d_Ddis VVPQSSSTTTKPPAK CK1d_Spur DEGAARTSSSRYIRK CK1d_Mmus -R-VASSGLQSVVHR CK1e_Mmus ----QTSVPFDHLGK CK1d_Hsap -R-VASSGLQSVVHR CK1e_Hsap ----QTSVPFDHLGK CC1G_04803_Ccin -----KAEEAERRKS CC1G_06627_Ccin -----AGRGRDAEVW AqueK089_Aque -MSAASRFKSAFSKK GK019_Glam -HR-NSKRFGGDFHF