CLUSTAL W (1.83) multiple sequence alignment CR4L_e-1_Smoe MDRCSGFQAILENSISLGRNSGRKNRALAKKWGLVCRFLVVSLLIPAARSLGSMSGIAPT CR4L_e-2_Smoe MDRCSGFQAILENSVSLGRNSGRKNRALAKKWGLVCRFLVVSLLIPAARSLGSMSGIAPT CR4L_b_Smoe MGALS------------------------K------------------------------ CR4L_d_Smoe MTF--------------GGKSSPPSLTYSRTILF-VFFLEFLSSAKMVLGLGGMCSIAAS CR4L_a-1_Smoe MVHLS------------------------CK----------------------------- CR4L_a-2_Smoe MVHLS------------------------CK----------------------------- CR4L_c_Smoe MGALS------------------------K------------------------------ * CR4L_e-1_Smoe YPEA--RICGIVPGLAGSIISCAGSNNSASPPLSYGDASFVGISGGNGFFCALREWTRQP CR4L_e-2_Smoe YPEA--RICGIVPGLAGSIISCAGSNNSASPPLSYGDASFVGISGGNGFFCALREWTRQP CR4L_b_Smoe ------------------------------------------------------------ CR4L_d_Smoe YGEDDPLFCAVEATF-EQQVFCWGRNESLEWP-STGPA-MLGLSGGMGFMCGIAAGSQRP CR4L_a-1_Smoe ------------------------------------------------------------ CR4L_a-2_Smoe ------------------------------------------------------------ CR4L_c_Smoe ------------------------------------------------------------ CR4L_e-1_Smoe FCWDAMNFSSR----SRLSSASYSQIAVGDSHVCGIRSIDGGVDCWRGIGIAAPTNLANL CR4L_e-2_Smoe FCWDSMNFSSR----SRLSSASYSQIAVGDSHVCGIRSIDGGVDCWRGIGMAAPTNLANL CR4L_b_Smoe ------------------------------------------------------------ CR4L_d_Smoe FCWRK-NLTSINIVPEQFQNTSYDSIAAGDGHVCAARSQDALVDCWNGDDSLNVPRGVTL CR4L_a-1_Smoe ------------------------------------------------------------ CR4L_a-2_Smoe ------------------------------------------------------------ CR4L_c_Smoe ------------------------------------------------------------ CR4L_e-1_Smoe TSITSGSNFSCGIVASN-GSVVCWGDESIQRRFQPSQGSFSSVQAGGQHVCGLYSSFGTV CR4L_e-2_Smoe TSITSGSNFSCGIVASN-GSVVCWGDESIQRRFQPSQGSFSSVQAGGQHACGLYSSFGTV CR4L_b_Smoe ------------------------------------------------------------ CR4L_d_Smoe RSLVAGRRFVCGIETGDGGTARCWGDANLAATAPPGDVEFESLSAGGEHACGIVRKSREI CR4L_a-1_Smoe ------------------------------------------------------------ CR4L_a-2_Smoe ------------------------------------------------------------ CR4L_c_Smoe ------------------------------------------------------------ CR4L_e-1_Smoe SYCWGDNTYGQLDFPPSVEFFAFALGQRHSCGLDRSTRQALCWGDNSTSQLAAPAGVRFD CR4L_e-2_Smoe SYCWGDNTYGQLDFPPSVEFFAFALGQRHSCGLDRSTRQALCWGDNSTSQLAAPAGVRFD CR4L_b_Smoe ------------------------------------------------------------ CR4L_d_Smoe -RCWGDNRLGQTDAPRGIPFVVLSLGLNHGCAVRQDTHGVMCWGRGFN-ASAAPDRTEFL CR4L_a-1_Smoe ------------------------------------------------------------ CR4L_a-2_Smoe ------------------------------------------------------------ CR4L_c_Smoe ------------------------------------------------------------ CR4L_e-1_Smoe SIAAGDFYTCGVRSGDLGVTCWGSV---SIGLSQSLPGSCSSGQCAAESYALVNATGNSS CR4L_e-2_Smoe SIAAGDFYTCGVRSGDLGVTCWGSV---SIGLSQSLPGSCSSGQCAAESYALVNVTGNSS CR4L_b_Smoe -------LWCLGPRRCQ------------------------------------------- CR4L_d_Smoe ALASSRVVTCGVREDNLLVVCWGNGTEFAPPLQLSSPGVCTAAPCSAGEFSF-NASSLGV CR4L_a-1_Smoe --TESAVITCKAHKDDI------------------------------------------- CR4L_a-2_Smoe --TESAVITCKAHKDDI------------------------------------------- CR4L_c_Smoe -------LWCLGPRRCQ------------------------------------------- * CR4L_e-1_Smoe VCGG-----FNHVCVSCT-RCPEGAIEEVPCGITGGDRQCSS---------------SPP CR4L_e-2_Smoe VCGG-----FNHVCVSCT-RCPEGAIEEVPCGITGGDRQCSL---------------SPP CR4L_b_Smoe ------------------------------------------------------------ CR4L_d_Smoe VTAGLCSSSTQQVCAPCASDCSNGSFVSAPCGAND-NRRCTDCSLCETSLCRGLCHLSPA CR4L_a-1_Smoe ------------------------------------------------------------ CR4L_a-2_Smoe ------------------------------------------------------------ CR4L_c_Smoe ------------------------------------------------------------ CR4L_e-1_Smoe PPALAPPPPPPGR-SRRRRLSNVEIVSVVLGSTGMLLGLVA-IAFCSWSRLRKR----SE CR4L_e-2_Smoe PPPLAPPPPPPGR-SRRRRLSNVEIVSVVLGSTGMLLGLVA-IAFCSWSRLRKR----SE CR4L_b_Smoe ------------------------------------------------------------ CR4L_d_Smoe PESSA-----VGVEERRHRAVSLAAVLGAAISGGVVVAVIGLLAWCCLQRRRGRWWRNSG CR4L_a-1_Smoe ------------------------------------------------------------ CR4L_a-2_Smoe ------------------------------------------------------------ CR4L_c_Smoe ------------------------------------------------------------ CR4L_e-1_Smoe SGRIHHSV-NANNGSVTI--SQQQQLRRQRSGASYVTGSRRSLGR-AETFTLEELAAATD CR4L_e-2_Smoe SGRIHHSV-NANNGSVTI--SQQQQLRRQRSGASYVTGSRRSLGR-AETFTLEELAAATD CR4L_b_Smoe -----------------------------------------DRVRLLTIYKFRDLELATG CR4L_d_Smoe SGRSGDGAYGHQNGGTGTGTSGGMQLQSVGSGGIP----CVKPPE-ALRYRLSELRDATG CR4L_a-1_Smoe -----------------------------------------EPAK-LKTFRYKDLEAATG CR4L_a-2_Smoe -----------------------------------------EPAK-LKTFRYKDLEAATG CR4L_c_Smoe -----------------------------------------DRVRLLTIYKFRDLELATG . . : :* **. CR4L_e-1_Smoe NFSDDNRIGTGSFGTVYRGVLPDGREVAIKRGGVGSSGMDAIAKKKFQDKESAFQSELEF CR4L_e-2_Smoe NFSDDNRIGTGSFGTVYRGVLPDGREVAIKRGGVGSSGMDAIAKKKFQDKESAFQSELEF CR4L_b_Smoe NFAEENLLGRGSYGSVYKAVLKNGQLAAVKRATCT--------TANPS-----TSKERFI CR4L_d_Smoe NFKEVNELGRGSYGFVYKAVLGDGQLVAVKRANAA--------QRIHGS-SRDFDAELEI CR4L_a-1_Smoe GFAREFLLGKGSYGWVYKGCLRDGKLVAVKRSSLA--------RKNSQD-DNPLDNELEI CR4L_a-2_Smoe GFAREFLLGKGSYGWVYKGCLRDGKLVAVKRSSLA--------RKNSQD-DNPLDNELEI CR4L_c_Smoe NFAEENLLGRGSYGSVYKAVLKNGQLAAVKRATCT--------TANPS-----TSKERFI .* :* **:* **:. * :*: .*:**. . * : CR4L_e-1_Smoe LTRLHHRHLVTLVGFCAEDDERLLVYDFMPNGTVHDHLHGRKEEEHQERQEGGEIVPQQQ CR4L_e-2_Smoe LTRLHHRHLVTLVGFCAEDDERLLVYDFMPNGTQQERIFAI------------------- CR4L_b_Smoe LSQIECPHVVNLLGFCERNDEVLLVVEFMANGSLHDVLHSKLS----------------- CR4L_d_Smoe LCKLRHANIVNLVGYCGEMGERLLIYEFMPHGTLRDHLHGGL------------------ CR4L_a-1_Smoe LSKIRSTRLVNLVGYSRDNKETVLVVDYMANGTLHDILHCRN------------------ CR4L_a-2_Smoe LSKIRSTRLVNLVGYSRDNKETVLVVDYMANGTLHDILHCRN------------------ CR4L_c_Smoe LSQIECPHVVNLLGFCERNDEVLLVVEFMANGSLHDVLHSKLS----------------- * ::. .:*.*:*:. * :*: ::*.:*: :: :. CR4L_e-1_Smoe ERIFAINLNSWQMRIGIALQAARGIEYLHTYAVPPIIHRDIKSSNILIDAECSARVSDFG CR4L_e-2_Smoe ------NLNSWQMRIGIALQAARGIEYLHTYAVPPIIHRDIKSSNILIDAECSARVSDFG CR4L_b_Smoe -----SSSLSWSRRVRIAVQTARALHALHS-STPQIIHRDVKSSNVLIDANWNARLGDFG CR4L_d_Smoe ------SPLGWGLRLRVAAQAARGLEFLHK-E--DVIHRDVKSANILLDAEWSARVAP-- CR4L_a-1_Smoe ------EPLSWSIRVQVALQIAKGLRALHS-ASPPVIHRDIKSSNVLIDADWNARLADFG CR4L_a-2_Smoe ------EPLSWSIRVQVALQIAKGLRALHS-ASPPVIHRDIKSSNVLIDADWNARLADFG CR4L_c_Smoe -----SSSLSWSRRVRIAVQTARALHALHS-STPQIIHRDVKSSNVLIDANWNARLGDFG . .* *: :* * *:.:. **. :****:**:*:*:**: .**:. CR4L_e-1_Smoe LSLMGPSDGESHLSLTAAGTVGYMDPEYYRLQQLTTKSDVYSFGVVLLEILTGKRAIIVE CR4L_e-2_Smoe LSLMGPSDGESHLSLTAAGTVGYMDPEYYRLQQLTTKSDVYSFGVVLLEILTGKRAIIVE CR4L_b_Smoe LALRGDTKDI---MCTPAGTLGYVDPRYDKPEKVGPKIDVFSFGVLLLELISGRQVIDDR CR4L_d_Smoe ------------------PDAGYRDPEYSTAPRMTAADDVYGFGVVLLELLSGRKAYDCE CR4L_a-1_Smoe LALRGRIEDVIRLSTPPAGTMGYLDPGYVSPGHLSTKTDVFSFGILLLEIMSGRNAIDVQ CR4L_a-2_Smoe LALRGRIEDVIRLSTPPAGTMGYLDPGYVSPGHLSTKTDVFSFGILLLEIMSGRNAIDVQ CR4L_c_Smoe LALRGDTKDI---MCTPAGTLGYVDPRYDKPEKVGPKIDVFSFGVLLLELISGRQVIDDR ** ** * :: . **:.**::***:::*:.. . CR4L_e-1_Smoe NRLKLRQNPQLPVNVVDFAVPFILAGQVISILDPRIGLPEEADEMEAVLIVAELAEECVR CR4L_e-2_Smoe NRLKLRQNPQLPVNVVDFAVPFILAGQVISILDPRIGVPEEADEMEAVLIVAELAEECVR CR4L_b_Smoe ---------MSPVRMVDWALPLIKQGRALAICDPRVRIPEG--EAAGIKRMAVLAARCVR CR4L_d_Smoe ---------FEPAGVAEWAGPLIRTGRWAEVVDRAVEGPRS---VEPVARLAEIAEKCVR CR4L_a-1_Smoe ---------YYPPNIVDWALPLIKQGKGAAICDPKSKHPTN---AEALNEMAGVAARCVR CR4L_a-2_Smoe ---------YYPPNIVDWALPLIKQGKGAAICDPKSKHPTN---AEALNEMAGVAARCVR CR4L_c_Smoe ---------MSPVRMVDWALPLIKQGRALAICDPRVRIPEG--EAAGIKRMAVLAARCVR * :.::* *:* *: : * * : :* :* .*** CR4L_e-1_Smoe LEGKERPSMGEIVSRLESAVAVL----------------------------------NRS CR4L_e-2_Smoe LEGKERPSMGEIVSRLESAVAVL----------------------------------NRS CR4L_b_Smoe RE-SKRPCMGDIVLTLSPPSPLA-------------GSRQMLGTG----------TWHRA CR4L_d_Smoe VRAEERPPMGQVAVWLEQIAQ--------------------------------------- CR4L_a-1_Smoe LSSSRRPTMAEVVKELREISKRIQMPIWNSIVKPLKSSLDLAAEGYDQWKLYKRSSLLEV CR4L_a-2_Smoe LSSSRRPTMAEVVKELREISKRIQMPIWNSIVKPLKSSLDLAAEGYDQWKLYKRSSLLEV CR4L_c_Smoe RE-SKRPCMGDIVLTLCQIQRDR----------------FHT---------------SRS ..** *.::. * CR4L_e-1_Smoe ERRRK---------------------KKQELRSSSNSSSSG------------------- CR4L_e-2_Smoe ERRRK---------------------KQQELRSSSNSSSSG------------------- CR4L_b_Smoe PKRFASPHGIYARVIGKCICHIIFVLPHTLYQASSDSDSDCHIGRKNFFEILLRLD---- CR4L_d_Smoe --------------------------------------GSG------------------- CR4L_a-1_Smoe KRKLE---------------------SKKIVNSSSASSSSAASREGSSCSSLAIGDDPCM CR4L_a-2_Smoe KRKLE---------------------SKKIVNSSSASSSSAASREGSSCSSLAIGDDPCM CR4L_c_Smoe SRKMVIKR----AILSC-PKDTAVISFDERFSSSSKSKSKWSLQQGGEQQKVIKVD---- .. CR4L_e-1_Smoe ------------------------------------------------------------ CR4L_e-2_Smoe ------------------------------------------------------------ CR4L_b_Smoe -EAVHSPGDQPRRNGMRPHVITLQSDGQHIHWDGMGPHAILQAFAPPPAEPLPQFPPHNV CR4L_d_Smoe ------------------------------------------------------------ CR4L_a-1_Smoe DPIVKAPGTRRARVRMI------------------------------YAED--KLKL--- CR4L_a-2_Smoe DPIVKAPGTRRARVRMI------------------------------YAED--KLKL--- CR4L_c_Smoe ---------------V------------------------------PYRKL--EFPP--- CR4L_e-1_Smoe -------------------QL CR4L_e-2_Smoe -------------------QL CR4L_b_Smoe SNNQTVFFCV--------NNL CR4L_d_Smoe -------------------SL CR4L_a-1_Smoe DVNKTSKNRSNGPKMGDFLLA CR4L_a-2_Smoe DVNKTSKNRSNGPKMGDFLLT CR4L_c_Smoe PINQPVTLRS--------SHI