CLUSTAL W (1.83) multiple sequence alignment mnb_Dmel MHHHS------------------------------------------------------- DYRK1B_Mmus MAVPP------------------------------------------------------- DYRK1A_Mmus MHTGGE----------------------TSACKPSSVRLAPSFSFH-------------- mbk-1_Cele MFPTLSS------------------VVESAACRVACPRLSPLTTLFRALSFTCDLSSVFL DYRK1B_Hsap MAVPP------------------------------------------------------- DYRK1A_Hsap MHTGGE----------------------TSACKPSSVRLAPSFSFH-------------- Dyrk1_Ddis MDSD-------------------------------------------------------- DYRK1_Spur MTIDHVRHYRLYMQHLKDRKRRSLNGCDDVYCL--TEQLNGDMSVH-------------- AqueK110_Aque ------------------------------------------------------------ AqueK111_Aque MDGSSS----------------------DS------------------------------ GK031_Glam M----------------------------------------------------------- mnb_Dmel -------------------------------------------SPSS------------- DYRK1B_Mmus -----------------------------------------GHGPFSGF----P---GPQ DYRK1A_Mmus ------------------------------AAGLQMAAQMPHSHQYSDRRQ-------PS mbk-1_Cele FASPMNFYRFINNCSGTTCFFLENMNTADVPDNLQSWGQQPSSS-YSNTQQHSQMTNLPP DYRK1B_Hsap -----------------------------------------GHGPFSGF----P---GPQ DYRK1A_Hsap ------------------------------AAGLQMAGQMPHSHQYSDRRQ-------PN Dyrk1_Ddis ------------------------------------------------------------ DYRK1_Spur ------------------------------CSSTQLNGQPAATHPASGSQETPT---GPN AqueK110_Aque ------------------------------------------------------------ AqueK111_Aque ------------------------------------SLQQHHSHSSSD------------ GK031_Glam ------------------------------------------------------------ mnb_Dmel ------------------------------------------SSEVRAMQARIP------ DYRK1B_Mmus -------------------------------------EHTQVLPDVRLLPRRLP------ DYRK1A_Mmus ISDQQVS-ALP------------------YSDQIQQPLTNQVMPDIVMLQRRMP------ mbk-1_Cele INHNNLCDTEPMNEDFQLQDVQADELQKQQKQQEQ-QHIQQQNAQRFIAQSRQPHSNILR DYRK1B_Hsap -------------------------------------EHTQVLPDVRLLPRRLP------ DYRK1A_Hsap ISDQQVS-ALS------------------YSDQIQQPLTNQVMPDIVMLQRRMP------ Dyrk1_Ddis ------------------------------------------------------------ DYRK1_Spur VA-------------------------------HREPILQQQAEEMAAMQSRIP------ AqueK110_Aque ------------------------------------------------------------ AqueK111_Aque ------------------------------------------------------------ GK031_Glam ------------------------------------------------------------ mnb_Dmel ------------------------------------------------------------ DYRK1B_Mmus ------------------------------------------------------------ DYRK1A_Mmus ------------------------------------------------------------ mbk-1_Cele FPQPPITSIKTNSHAFYPQQEVTQVRPKKHRVSMTNAEAALTPGMPPEKQAAKKRNIGQF DYRK1B_Hsap ------------------------------------------------------------ DYRK1A_Hsap ------------------------------------------------------------ Dyrk1_Ddis ------------------------------------------------------------ DYRK1_Spur ------------------------------------------------------------ AqueK110_Aque ------------------------------------------------------------ AqueK111_Aque ------------------------------------------------------------ GK031_Glam ------------------------------------------------------------ mnb_Dmel -------------------------NHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKR DYRK1B_Mmus -------------------------LAFRDAASAPLRKLSVDLIKTYKHINEVYYAKKKR DYRK1A_Mmus -------------------------QTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKR mbk-1_Cele STDTVPAGIGMIGIPFESTSKPLQIQQFRNPQDAPVRKLTSDLIKTYKAINESFYLRKQV DYRK1B_Hsap -------------------------LAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKR DYRK1A_Hsap -------------------------QTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKR Dyrk1_Ddis ---------------------------AKSRNDAPIIKLSIDLIKTYKHINQVYYTAKAK DYRK1_Spur -------------------------HTFRDATHAPLRKLSIDLIKTYKHINEVYYAKKKR AqueK110_Aque ------------------------------------------------------------ AqueK111_Aque ---------------------------PRQQHVSVVKKLTVDLIKTYRTINEVYYKKRRI GK031_Glam -------------------------------SGRPIIALTLDIEKTYRGIHGLTS---KL mnb_Dmel RAQQTQGDDDSSNK---------------------------------------------- DYRK1B_Mmus RAQQAPPQ-DSSTK---------------------------------------------- DYRK1A_Mmus RHQQGQGD-DSSHK---------------------------------------------- mbk-1_Cele RRDRHKSQ-DAGKPKGS------------------------------------------- DYRK1B_Hsap RAQQAPPQ-DSSNK---------------------------------------------- DYRK1A_Hsap RHQQGQGD-DSSHK---------------------------------------------- Dyrk1_Ddis KKQQAQQQA-QQQA-QQLQQQAQQQQHQLQQQQQLLQQQQQQQQQQQQQQQQQQQQQQQQ DYRK1_Spur RALPAQGD-DTSHK---------------------------------------------- AqueK110_Aque ------------------------------------------------------------ AqueK111_Aque SDRTDQSNGAGASS---------------------------------------------- GK031_Glam RTGVNQPQ-MASMR---------------------------------------------- mnb_Dmel ------------------------------------------------------------ DYRK1B_Mmus ------------------------------------------------------------ DYRK1A_Mmus ------------------------------------------------------------ mbk-1_Cele ------------------------------------------------------------ DYRK1B_Hsap ------------------------------------------------------------ DYRK1A_Hsap ------------------------------------------------------------ Dyrk1_Ddis QQQQQQYQQQHNNNINNNNNNSNINNKNNNNNNTNFNTSNNNNNTNNNSNNNSNNNNSNN DYRK1_Spur ------------------------------------------------------------ AqueK110_Aque ------------------------------------------------------------ AqueK111_Aque ------------------------------------------------------------ GK031_Glam ------------------------------------------------------------ mnb_Dmel ------------------------------------------------------------ DYRK1B_Mmus ------------------------------------------------------------ DYRK1A_Mmus ------------------------------------------------------------ mbk-1_Cele -------------------------------------------------KDGSGASLTDT DYRK1B_Hsap ------------------------------------------------------------ DYRK1A_Hsap ------------------------------------------------------------ Dyrk1_Ddis NNNNNNINNINNININNKNNNNNNNNNNNINNINNNNNKNNNNNNNNNNNDDN------- DYRK1_Spur ------------------------------------------------------------ AqueK110_Aque ------------------------------------------------------------ AqueK111_Aque ------------------------------------------------------------ GK031_Glam ------------------------------------------------------------ mnb_Dmel ------------------------------------------------------------ DYRK1B_Mmus ------------------------------------------------------------ DYRK1A_Mmus ------------------------------------------------------------ mbk-1_Cele FSIHNAIPITSSDNH--------------------------------------------- DYRK1B_Hsap ------------------------------------------------------------ DYRK1A_Hsap ------------------------------------------------------------ Dyrk1_Ddis --------------NNINNNNSNNNNNNNNNNNNNNNNNNNNNNNNNSNNNNNNNNLNNN DYRK1_Spur ------------------------------------------------------------ AqueK110_Aque ------------------------------------------------------------ AqueK111_Aque ------------------------------------------------------------ GK031_Glam ------------------------------------------------------------ mnb_Dmel ----------------------------------------------KERKLYNDGYDDDN DYRK1B_Mmus ----------------------------------------------KEKKVLNHGYDDDN DYRK1A_Mmus ----------------------------------------------KERKVYNDGYDDDN mbk-1_Cele -----YQQDAHQNAPPLLDTNAPPTSTMVVPMRTETDLQQQQRQKSSRGGPYNNGYDDQN DYRK1B_Hsap ----------------------------------------------KEKKVLNHGYDDDN DYRK1A_Hsap ----------------------------------------------KERKVYNDGYDDDN Dyrk1_Ddis NSNNNYN-------------------------NNTTTTSSSNNNNNNKQSKYNDGYDDEN DYRK1_Spur ----------------------------------------------KEKRLYNDGYDDDN AqueK110_Aque ------------------------------------------------------------ AqueK111_Aque ----------------------------------------------SRRSIKSEQYDDEN GK031_Glam ----------------------------------------------PQ--------TDDR mnb_Dmel HDYIIKNGEKFLDRYEI--DSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQI DYRK1B_Mmus HDYIVRSGERWLERYEI--DSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQI DYRK1A_Mmus YDYIVKNGEKWMDRYEI--DSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI mbk-1_Cele YDYILKNGEIFDKRYVILSDTPVGKGSFGQVTKAYDTLNKEEVAIKIIKNKKTFFDQAQI DYRK1B_Hsap HDYIVRSGERWLERYEI--DSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQI DYRK1A_Hsap YDYIVKNGEKWMDRYEI--DSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI Dyrk1_Ddis ADYIVRIGEVFVDRFEI--ISSLGKGSFGQVVKAFDSVLKEYVAIKIIKNKVPFYNQALI DYRK1_Spur YDYIIKNGEKWNDRYEI--DSLIGKGSFGQVAKAYDHQEQEYVAIKIIKNKKPFLNQAQI AqueK110_Aque ------------------------------------------------------------ AqueK111_Aque HDYKVKPGERWLDRYEI--DSLIGKGSFGQVVKAFDLEEREWVAIKVIKNKRAFYQQALI GK031_Glam GYLIVRINDCFNGRYCA--ERPLGQGSFGRVVLAKDTVNNAYVAIKIMKAGKLFTHKGRE mnb_Dmel EVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLT DYRK1B_Mmus ELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLT DYRK1A_Mmus EVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLT mbk-1_Cele EIHLLELTNAHDKDNKYNIVTLKGHFVHRAHLCLVFELLSYNLYDLLKNTSFRGVSLNLA DYRK1B_Hsap ELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLT DYRK1A_Hsap EVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLT Dyrk1_Ddis EIRLLELMNNKDPEDQYKIIKLKHHFKFRNHLCIVTELLSYNLYDLLRNTHFHGVSLNLI DYRK1_Spur EVRLLELMNKHDADSKYYIVKLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLT AqueK110_Aque ------------------------------------------------------------ AqueK111_Aque EKRLLELLNSRDPEGKYYIVSLKRSFTFRGHLCFVFELLSYNLYELLRNTNFRGVSLNLT GK031_Glam EAEIMSLLSDEDPPISCKF---IESFMQGNHYCIVMEALGSNLYHLLKSTKMQGFPLQTI mnb_Dmel RKFAQQLCTALLFLSTPELNIIHCDLKPENILL--CNPKRSAIKIVDFGSSCQLGQ-RIY DYRK1B_Mmus RKLAQQLCTALLFLATPELSIIHCDLKPENILL--CNPKRSAIKIVDFGSSCQLGQ-RIY DYRK1A_Mmus RKFAQQMCTALLFLATPELSIIHCDLKPENILL--CNPKRSAIKIVDFGSSCQLGQ-RIY mbk-1_Cele RKFAQQLGKTLLFLSSPELSIIHCDLKPENVLL--VNAKRSQIRVIDFGSSCQTGH-RIY DYRK1B_Hsap RKLAQQLCTALLFLATPELSIIHCDLKPENILL--CNPKRSAIKIVDFGSSCQLGQ-RIY DYRK1A_Hsap RKFAQQMCTALLFLATPELSIIHCDLKPENILL--CNPKRSAIKIVDFGSSCQLGQ-RIY Dyrk1_Ddis KKFAHQILTALFFMSTPEVDVIHCDLKPENILL--RNPKRSAIKIIDFGSSCHSNE-RMY DYRK1_Spur RKFAQQMCTALLFLATPELNIIHCDLKPENILL--CNPKRSAIKIIDFGSSCQLGQ-RIY AqueK110_Aque ------------------------------------------------------------ AqueK111_Aque RKFAQQLCTALLFLSTHDINVIHCDLKPENILL--CNPKRSAIRIVDFGSSCQVGS-RMF GK031_Glam RVWARKYLTSFKKLQHESIRIIHTDCKPENTLIPFNNTCVEDIRIVDFGSAVRYPEGQMF mnb_Dmel HYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGM DYRK1B_Mmus QYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGI DYRK1A_Mmus QYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGI mbk-1_Cele QYIQSRFYRSPEVLLGIAYDTKIDMWSLGCILVEMHTGEPLFAGSSEVDQMMKIVEVLGM DYRK1B_Hsap QYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGI DYRK1A_Hsap QYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGI Dyrk1_Ddis KYIQSRFYRSPEILLELEYSFSIDMWSLGCILVEMHVGEPLFSGQNEQDQLTKIIEVLDL DYRK1_Spur QYIQSRFYRSPEVLLGISYDMAIDMWSLGCILVEMHTGEPLFSGSNELDQMNKIIEVLGM AqueK110_Aque --------------------------------------------------MSKIVEVLGI AqueK111_Aque QYIQSRFYRSPEVLLGIPYDLAIDMWSLGCILVEMHTGEPLFSGKDEIDQMSKIVEVLGI GK031_Glam LYIQSRYYRAPEVLLLQPYDYQIDIWSIAAILFEMHTGKVLFPAKSSEILCYMMVDILGY ::::*. mnb_Dmel PPKYLLD-QAHK-----TRKFFDKIVADGSYVLKKNQNGRK--YKPPGSRKLHDILGVET DYRK1B_Mmus PPAPMLE-QAPK-----ARKYFERL-PGGGWTLRRTKELRKD-YQGPGTRRLQEVLGVQT DYRK1A_Mmus PPAHILD-QAPK-----ARKFFEKL-PDGTWSLKKTKDGKRE-YKPPGTRKLHNILGVET mbk-1_Cele PPKEMLD-IGPK-----THKYFDKT-EDGIYYCKKTRDGYRHTYKAPGARKLHEILGVTS DYRK1B_Hsap PPAAMLD-QAPK-----ARKYFERL-PGGGWTLRRTKELRKD-YQGPGTRRLQEVLGVQT DYRK1A_Hsap PPAHILD-QAPK-----ARKFFEKL-PDGTWNLKKTKDGKRE-YKPPGTRKLHNILGVET Dyrk1_Ddis PPSHMID-SSPK-----AKKFFTKDPINSTYQLKKNEKLKT--NVEFCKKKLSEIIGVET DYRK1_Spur PPNHIIE-QAPK-----AHKYFIKT--EKTWVLKRSRDGKK--YKSPRTRKLQDILGVEL AqueK110_Aque PPPHVLE-RSAR-----RDRFFERE-SGGTWVLKRQRDGRKDHHRRPGSRSLYEVLGGDK AqueK111_Aque PPPHVLE-RSAR-----RDRFFERE-SGGTWVLKRQRDGRKDHHRRPGSRSLYEILGGDK GK031_Glam PPKEMIMDEEQKQISNSLKRYFKMRKQEDAELFHLNENAFP-HQVVPDSYLLNKSVIEMA ** :: : ::* : .. * . : mnb_Dmel GGPGGR--------------RLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHN DYRK1B_Mmus GGPGGR--------------RAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHG DYRK1A_Mmus GGPGGR--------------RAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHS mbk-1_Cele GGPGGR--------------RLGEPGHSVEDYSKFKDLIKRMLQFDPKQRISPYYVVRHP DYRK1B_Hsap GGPGGR--------------RAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHG DYRK1A_Hsap GGPGGR--------------RAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHS Dyrk1_Ddis GGPQSR--------------RKNEPGHALVDYLKFLDLIEKMLIYDPQKRITPLEALQHS DYRK1_Spur GGPGGR--------------RAGEPGHTVSDPHKFKDPILRMLEYDPASRIKPYYALQHS AqueK110_Aque GGPGGL--------------RKGDSGHTPNDYYKFRDLVLQMLDYDPETRIKPLAALKHP AqueK111_Aque GGPGGL--------------RKGDSGHTPNDYYKFRDLVLQMLDYDPETRIKPLAALKHP GK031_Glam EAQKERIFGRPLRELIRNPVMTQYEGHTSADYEEFEEFLSKILVYDPKRRWTIDEALNSR . **: * .* : : ::* ::* * .:. mnb_Dmel FFKRTADEATNTSGAGA---TANAGAGGS-GSSGAGGSS--------------------- DYRK1B_Mmus FFRRTADEATNTGPAGSSASTSPAP-LDT-CPSSSTASS--------------------- DYRK1A_Mmus FFKKTADEGTNTSN---SVSTSPAM-EQS-QSSGTTSST--------------------- mbk-1_Cele FLKQKEERVPSQPPVSHSNLQQQQQ-LYIQQPSSQMSQV--------------------- DYRK1B_Hsap FFRRTADEATNTGPAGSSASTSPAP-LDT-CPSSSTASS--------------------- DYRK1A_Hsap FFKKTADEGTNTSN---SVSTSPAM-EQS-QSSGTTSST--------------------- Dyrk1_Ddis FFLTDE-TSQPPQQQSQQQSQQQSQ-QQS-QQQSQQQ----------------------- DYRK1_Spur FFKRTADGSTNTSN---STSASPAM-DQA-GSPPAEHSS--------------------- AqueK110_Aque FFRKEARLSQSSENGSQYSSTTPTQ-TIG-LTSSSSQPIDSFVISQEIVAMETNHTHPPP AqueK111_Aque FFRKEARLSQSSENGSQYSSTTPTQ-TIG-LTSSSSQPIDSFVISQEIVAMETNHTHPPP GK031_Glam F----------------------------------------------------------- * mnb_Dmel -----------------------GGGVGGGLGASNSSSGAVSSSSAAAPTAATAAATAAG DYRK1B_Mmus -----------------------ISSSGGSSGSSNDN------RA-------YRYS---- DYRK1A_Mmus -----------------------SSSSGGSSGTSNSG------RARSDPTHQ-------- mbk-1_Cele -----------------------MESPSVGSVYVEDN------GM-------YRQA---- DYRK1B_Hsap -----------------------ISSSGGSSGSSSDN------RT-------YRYS---- DYRK1A_Hsap -----------------------SSSSGGSSGTSNSG------RARSDPTHQ-------- Dyrk1_Ddis -------------------------SQ--------QR------RQS-NTD--NNFS---- DYRK1_Spur -----------------------GSSSGGATGGSNNGSGTGG-RAQSDPTHQNSTS---- AqueK110_Aque GLGELIPGRHIHLQNLSPPETHDASLYGGNNGRGVVG------SSGTLGS--GTFS---- AqueK111_Aque GLGELIPGRHIHLQNLSPPETHDTSLYGGNNGRGVVG------SSGTLGS--GTFS---- GK031_Glam ------------------------------------------------------------ mnb_Dmel SSGSGSSVGGG-S-SAAQQ------QQ---------------------AMPLPL-PLPLP DYRK1B_Mmus ----NRYCGG---P--GPP------ITDC-------------------EMNSPQVLPSQP DYRK1A_Mmus ----HRHSGGH--FAAAVQ------AMDC-------------------ETHSPQVRQQFP mbk-1_Cele -------PGSSANPISVTSSFDEGDAMEVDAGRRRFSAHQQNYHNPNYQYSQPQQQQQQQ DYRK1B_Hsap ----NRYCGG---P--GPP------ITDC-------------------EMNSPQVPPSQP DYRK1A_Hsap ----HRHSGGH--FTAAVQ------AMDC-------------------ETHSPQVRQQFP Dyrk1_Ddis ----NNN--------P---------IN--------------NYNSPSS--KSPHQQLQQ- DYRK1_Spur ----NHALGHQ-HPGSSAG------AMDY-------------------ESMSSHSSLT-- AqueK110_Aque ----N--SGS---FGSAM---------D---------------------IGQPQQPVA-- AqueK111_Aque ----N--SGS---FGSAM---------D---------------------IGQPQQPVA-- GK031_Glam ------------------------------------------------------------ mnb_Dmel LP-PLAGPGGASDGQCHGLLMHSVAANAMNNFSALSLQSNAHPPPSLANSHHSTNSLGSL DYRK1B_Mmus LR-PWAG---------------------------------GDV----------------- DYRK1A_Mmus APLGWSG---------------------------------TEAPTQVTVETHPVQ--ETT mbk-1_Cele YQ-QTQ---------------------------------------RTQLEQQQK---QAQ DYRK1B_Hsap LR-PWAG---------------------------------GDV----------------- DYRK1A_Hsap APLGWSG---------------------------------TEAPTQVTVETHPVQ--ETT Dyrk1_Ddis ------------------------------------------------------------ DYRK1_Spur -S-GMSS---------------------------------GDVA---------------- AqueK110_Aque ----------------------------------------------MTM----------- AqueK111_Aque ----------------------------------------------MTM----------- GK031_Glam ------------------------------------------------------------ mnb_Dmel NHISPGSTGCHNNNSNSSNNNTRHSRLYGSNMVNMVGHHNSGSSNNHNSISYPHAMECDP DYRK1B_Mmus ---------------------P---------------HKTHQA----------------- DYRK1A_Mmus FHVAPQQNALHHHHGNSSHHHHHHHHH---------HHHHGQQALGNRT--RPRVYNS-- mbk-1_Cele LQQQLQQQQMQQQQ--QQQQQRQHMPQ---------AQSSSQQHLQSRA--RPRQQDQ-- DYRK1B_Hsap ---------------------P---------------HKTHQA----------------- DYRK1A_Hsap FHVAPQQNALHHHHGNSSHHHHHHHHH---------HHHHGQQALGNRT--RPRVYNS-- Dyrk1_Ddis ----------------QQQQQ-QQQQQ---------QQQQQQQQQQQQQ--Q--QTYS-- DYRK1_Spur --FASSSSSAHGHSSSHTYPHPHSHSR---------KHHHHHSSHG-HS--L----PS-- AqueK110_Aque -------------EASSSLHQ-VTGSH---------RPHSGRKGEGGER--K--GGPS-- AqueK111_Aque -------------EASSSLHQ-VTGSH---------RPHSGRKGEGGER--K--RGPS-- GK031_Glam ------------------------------------------------------------ mnb_Dmel PQMPPPPPNGHGRMRVPAIMQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASHLMMT DYRK1B_Mmus ---------------------------------------P-----------ISASTL--- DYRK1A_Mmus ------------------------------------PTN--------------SSST--- mbk-1_Cele ------------------------------------NE-W-----------RNQFEL--- DYRK1B_Hsap ---------------------------------------P-----------ASASSL--- DYRK1A_Hsap ------------------------------------PTN--------------SSST--- Dyrk1_Ddis ------------------------------------PTT--------------QQSN--- DYRK1_Spur ------------------------------------PAAP-----------ASNVNL--- AqueK110_Aque ------------------------------------PNA--------------SLHN--- AqueK111_Aque ------------------------------------PNA--------------SLHN--- GK031_Glam ------------------------------------------------------------ mnb_Dmel DSSVISASAAGGGQGGGNPGQNPVTPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPLPM DYRK1B_Mmus --------PGTGAQLPPLPRCLGRPPSPTSP-----------------------PPPELM DYRK1A_Mmus ---------QDSMEV--------------------------------------------- mbk-1_Cele ---------DDTFQQ--------------------------------------------- DYRK1B_Hsap --------PGTGAQLPPQPRYLGRPPSPTSP-----------------------PPPELM DYRK1A_Hsap ---------QDSMEV--------------------------------------------- Dyrk1_Ddis ---------HKLVDQ--MKKASMKDKSPHSN----------------------------- DYRK1_Spur --------SQTVLQAPIV--TMGIPTIPVTM-----------------------GMPHVH AqueK110_Aque ---------GGGVQV--------------------------------------------- AqueK111_Aque ---------GGGVQV--------------------------------------------- GK031_Glam ------------------------------------------------------------ mnb_Dmel SVPLQLPP----------------------SSSSSVS---------SGS---ASVGSGGV DYRK1B_Mmus DVSL-------------------------------------------------------- DYRK1A_Mmus --------GHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDV mbk-1_Cele --------KQ------RKVDDSVSNQISRN----Q------------------------- DYRK1B_Hsap DVSL-------------------------------------------------------- DYRK1A_Hsap --------GHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDV Dyrk1_Ddis -ISNILN----------DSEEDN-SKVHINSNTSDNMQARINFQVENQSNIYNNNNN--- DYRK1_Spur QAGIVTTPGYVYSSHSSLENT-QSSSLSSGSL---------NMPMGAYAIPTHHHPSSTT AqueK110_Aque --------FYGTNSLFPQSSDSNFSFQMSPSSSSKGRGAHVPHHVTEREGVRTRSGA--- AqueK111_Aque --------FYGTNSLFPQSSDSNFSFQMSPSSSSKGGGAHVPHHVTEREGVRTRSGA--- GK031_Glam ------------------------------------------------------------ mnb_Dmel GVGVVGQRRH---------------ITGPAAQV-GISQSVGSGSS------GSATGASSS DYRK1B_Mmus ----VGSPPD---------------CSPPPPAP-APQHPAASALR-TRMTGGRPPLPPPD DYRK1A_Mmus NLTVYSNPRQ---------------ETGIAGHP-TYQFSANTGPA-HYMTEGHLAMRQGA mbk-1_Cele -----------------------------------------FNPQQVSMTHGNVNANNRE DYRK1B_Hsap ----VGGPAD---------------CSPPHPAP-APQHPAASALR-TRMTGGRPPLPPPD DYRK1A_Hsap NLTVYSNPRQ---------------ETGIAGHP-TYQFSANTGPA-HYMTEGHLTMRQGA Dyrk1_Ddis ----NNNNNN--------------------------NNNNNNNS-NNYNNSNE---LSPN DYRK1_Spur QQTLVNNPHLHGTTTGTGGIALTSNVSGATSVPYAFALPVQSAVS-----TGLVNS-QTT AqueK110_Aque ----GPNSRN---------------QKSYRHHH---HHHRRTHPS-----EG---GASGS AqueK111_Aque ----GSNSRN---------------QKSYRHHH-HHHHHRRTHPS-----EG---GASGS GK031_Glam ------------------------------------------------------------ mnb_Dmel DASSSSPMV-GV-CVQQNPVVIH DYRK1B_Mmus DPATLGPRL-GLHGVPQSTAASS DYRK1A_Mmus D-REESPMT-GV-CVQQSPVASS mbk-1_Cele MEK------------LDYPNNKL DYRK1B_Hsap DPATLGPHL-GLRGVPQSTAASS DYRK1A_Hsap D-REESPMT-GV-CVQQSPVASS Dyrk1_Ddis P-----PILPNLKDLLPHNNNNI DYRK1_Spur RQADDSPMV-GV-CVQQSPVASH AqueK110_Aque HDDQGGSMV-GV-------TVHQ AqueK111_Aque HDDQGGSMV-GV-------TVHQ GK031_Glam --------------------LSH