CLUSTAL W (1.83) multiple sequence alignment smi35A_Dmel MLDRCEMPIQL---------------------------DN---EK--------------- Dyrk3_Dmel MINQNLTHTGIA-------------Q----N-------NT-------------------- DYRK4_Mmus MQLLRLPALTRT-------------E--TSM-------DT---NK----AR--------- DYRK3_Mmus MGGAARDRGRKD-------------A-A--L-------PG---A-----GL--------- DYRK2_Mmus MLTRKPSAAAPA-------------A----Y-------PT---GR----GG--------- mbk-2_Cele MAALASFTRNSR-------------S-YGQQ-------PIDVTQQ----GQ--------- C36B7.2_Cele MADIQRHFSNLV-------------I------------GA----S----P---------- C36B7.1_Cele MSLLIKSVQIVK-------------L------------HA----F--------------- DYRK4_Hsap MQLLPPPIRTGT-------------K--TQM-------DA---KK----PR--------- DYRK3_Hsap MGGTARGPGRKD-------------A-G--P-------PG---A-----GL--------- DYRK2_Hsap MLTRKPSAAAPA-------------A----Y-------PT---GR----GG--------- Dyrk2_Ddis MTSLHKQIIESH-------------NND--I-------TK----------L--------- 5306_Tthe MYIFNTFIQFCSQTKEAEKVQSTRNS----F-------AI---DQKNKDSI--------- 5356_Tthe MQFYNPNSSSSA-------------S----K-------NS---NI----KV--------- 5655_Tthe MHNNSSANN----------------S----F-------NN---EQ----AL--------- DYRK2_Spur MVDSMVDAIAR-------------------K-------PN---LQ----AS--------- DYRK4_Spur MPACLHGVASMG-------------K------------------R----P---------- CC1G_13957_Ccin MSASPDPPQQYK-------------A---------------------------------- AqueK112_Aque MERGTGSTKERS-------------F--SYS-------KA----T----PL--------- AqueK113_Aque MLAMYNSQSLTS-------------A------------NT-------------------- DYRK2_b_Smoe MAQTDRSAYADV-------------A---------------------------------- DYRK2_a_Smoe MAQTDRSAYADV-------------A---------------------------------- GK034_Glam MFAPGNSARAQR-------------Q-V--I-------PG---DHF---GL--------- GK033_Glam MDTITLIAGFLR-------------Q-HGENELAENVENC---ES----LR--------- GK032_Glam MIQPEALHQLIY----------------DHV-------YV---KY----GHQLAFTIRAL * smi35A_Dmel -----------------------------------------LRR---------------- Dyrk3_Dmel -E------------------------K--------------ANR---------------- DYRK4_Mmus ------------------------------------------KR---------------- DYRK3_Mmus -P------------------------P--------------QQR---------------- DYRK2_Mmus -D------------------------T--------------AVR---------------- mbk-2_Cele RD-RSVMSLD----------------A--------------QGR---------------- C36B7.2_Cele ------------------------------------------LT---------------- C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------KC---------------- DYRK3_Hsap -P------------------------P--------------QQR---------------- DYRK2_Hsap -D------------------------S--------------AVR---------------- Dyrk2_Ddis -K--SSMSTR----------------AA-------------ARRSVCLSSMSYTLG---- 5306_Tthe -L-Q----SN-------------------------------------------------- 5356_Tthe -Q-QN------------------------------------------------------- 5655_Tthe -L-ST---VD-------------------------------------------------- DYRK2_Spur -----------------------------------------RTR---------------- DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin ---------R----------------PA-------------ALAIHDDEGTQPSDGDDQI AqueK112_Aque -L------------------------PSLTSPRGSENGGSHFDR---------------- AqueK113_Aque -K------------------------T--------------FNR---------------- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam -V--I-TSG-----------------------------------------RSVSKG---- GK033_Glam -RETRI-TTDLEFLLNISRGCVTVETL--------------ANR---------------- GK032_Glam LN------------------------A--------------KER---------------- smi35A_Dmel ---------D------------------------------------------V------- Dyrk3_Dmel ---------H------------------------------------------Q------- DYRK4_Mmus ---------S------------------------------------------L------- DYRK3_Mmus ---------R------------------------------------------L------- DYRK2_Mmus ---------Q------------------------------------------L------- mbk-2_Cele ---------S-------VSHECPTSTTLVR---------------------QL------- C36B7.2_Cele ---------K------------------------------------------L------- C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ---------D------------------------------------------L------- DYRK3_Hsap ---------R------------------------------------------L------- DYRK2_Hsap ---------Q------------------------------------------L------- Dyrk2_Ddis --------AD------------------------------------------D------- 5306_Tthe -----------------IS---------QPESTKNHFGYQNQLAHQQIQQQQL----QQQ 5356_Tthe -----------------L------------------------------------------ 5655_Tthe -----------------LA---------SQ---------------------DI----SA- DYRK2_Spur ---------S------------------------------------------L------- DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin DNCQHQHLL--------------------------------------------------- AqueK112_Aque ---------S------------------------------------------FMRKGI-- AqueK113_Aque ---------T------------------------------------------L------- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam --------RD------------------------------------------Q------- GK033_Glam ---------SAMIKEHNM------------------------------------------ GK032_Glam ---------C------------------------------------------M------- smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------Y----R------------------------------------ DYRK4_Mmus ------------------T----T--------------------------FP-ILKARKK DYRK3_Mmus ------------------G----------------------------------------- DYRK2_Mmus ------------------Q----A------------------------------------ mbk-2_Cele ------------------Y----L------------------------------------ C36B7.2_Cele ------------------W----A------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------T----P--------------------------FL-VLKARKK DYRK3_Hsap ------------------G----------------------------------------- DYRK2_Hsap ------------------Q----A------------------------------------ Dyrk2_Ddis ------------------V----TPITSNTTPSNNNNNNNTTTTITTTTTTP-TISPL-K 5306_Tthe QQSLQQMQQQQQQMTLQQS----------------------------------------- 5356_Tthe ------------------N----------------------------------------- 5655_Tthe ------------------Q----------------------------------------- DYRK2_Spur ------------------T----Q------------------------------------ DYRK4_Spur ---------------------------------------------------------REK CC1G_13957_Ccin -----------------------QPLTINVSHQDNDDSNHSRSTSVTSSLDP-YYFGL-A AqueK112_Aque ------------------S----S--------------------------LSLSERESKK AqueK113_Aque ------------------V----Y------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------A----S------------------------------------ GK033_Glam ------------------ASTIDK-----------------------FVIHP-VFFGR-R GK032_Glam ------------------SKLVAS------------------------------------ smi35A_Dmel -R------------------------------------------------LS-------- Dyrk3_Dmel -----------------------------------------------------D------ DYRK4_Mmus QS------------------------------------------------FT-S------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus -----------------------------------------------------S------ mbk-2_Cele --------------------------------------------------PQ-I------ C36B7.2_Cele -----------------------------------------------------D------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap QK------------------------------------------------FT-S------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap -----------------------------------------------------S------ Dyrk2_Ddis QS------------------------------------------------TT-G------ 5306_Tthe -----------------------------------------------------Q------ 5356_Tthe -----------------------------------------------------N------ 5655_Tthe -----------------------------------------------------N------ DYRK2_Spur --------------------------------------------------G--D------ DYRK4_Spur NH------------------------------------------------IS-N------ CC1G_13957_Ccin ES------------------------------------------------PE-H------ AqueK112_Aque SH------------------------------------------------FT-H------ AqueK113_Aque --------------------------------------------------P--S------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam -----------------------------------------------------D------ GK033_Glam RALENEFLLEMFRDIDTKVDYLGLVPVTSKRYRMSVCHKQPYQHLYLKRIFPADQKLKGL GK032_Glam -----------------------------------------------------ES----- smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ---S-------------------------------------------------------- DYRK4_Mmus -VKV-------------------------------------------------------- DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ---P-------------------------------------------------------- mbk-2_Cele ---P-------------------------------------------------------- C36B7.2_Cele ---H-------------------------------------------------------- C36B7.1_Cele ---F-------------------------------------------------------- DYRK4_Hsap -AKV-------------------------------------------------------- DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ---P-------------------------------------------------------- Dyrk2_Ddis ---S-------------------------------------------------------- 5306_Tthe ---N-------------------------------------------------------- 5356_Tthe ---S-------------------------------------------------------- 5655_Tthe ---S-------------------------------------------------------- DYRK2_Spur ---T-------------------------------------------------------- DYRK4_Spur ---G-------------------------------------------------------- CC1G_13957_Ccin ---NPNQLSITPDHPPPNEPVTPARNPASIDRRGLVGVGELATPRWTRDPSPDPHLDDDV AqueK112_Aque -SLG-------------------------------------------------------- AqueK113_Aque ---S-------------------------------------------------------- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ---A-------------------------------------------------------- GK033_Glam APD--------------------------------------------------------- GK032_Glam ------------------------------------------------------------ smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ----------------------------------------------------G----L-- DYRK4_Mmus ----------------------------------------------------ESKPLGH- DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ----------------------------------------------------G----I-- mbk-2_Cele ----------------------------------------------------Q----SA- C36B7.2_Cele ----------------------------------------------------G----T-- C36B7.1_Cele ----------------------------------------------------Q----L-- DYRK4_Hsap ----------------------------------------------------GSKLSVQ- DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ----------------------------------------------------G----L-- Dyrk2_Ddis ----------------------------------------------------I------- 5306_Tthe ----------------------------------------------------Q----LNQ 5356_Tthe ----------------------------------------------------Q----L-- 5655_Tthe ----------------------------------------------------R----F-- DYRK2_Spur ----------------------------------------------------A----T-- DYRK4_Spur ----------------------------------------------------A----VK- CC1G_13957_Ccin PPLPDRPEDDAPDSPWTIEAIDGELSDSDEVSAPAPFPASNNVLIFLKVKIPE------- AqueK112_Aque ----------------------------------------------------G----VH- AqueK113_Aque ----------------------------------------------------E----V-- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ----------------------------------------------------P------- GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele -----------------SFAAAPTS-----------------------------FS---- C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis ---------------------IPKS-----------------------------IL---- 5306_Tthe QHQQQLIMMIQQQQQQQHGQQLPNQ----------------------------------- 5356_Tthe -----------------NNALSPKK-----------------------------NISLDL 5655_Tthe -----------------SSGPSPKS-----------------------------KNFVPI DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin ---------------------LPPP-----------------------------ARPL-- AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ---------------------IPQT-----------------------------V----- DYRK2_a_Smoe ---------------------IPQT-----------------------------V----- GK034_Glam ---------------------PPPP-----------------------------AR---- GK033_Glam ---------------------SPPAMGYARLSNPYMDYYKGETGFARQIILGHKI----- GK032_Glam ---------------------EPSAL----------------------------E----- smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele GASSSSSNHH-----------------------HP--V---------------------- C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis -------------------------------------------------VT--------- 5306_Tthe ----------------TSSKKSNQQ-----QQMQQNQI---------------------- 5356_Tthe GS-RKI----------------SPLDNSLRKR---IEY---------------------- 5655_Tthe TA-KNASNQQAIVMNAIKSKIQNIFQQQQQQRQQPQQL---------------------- DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin -----------------------------RT-----RPSIADESGGEEILYPRNVIQSVP AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele ------------------------------------------------------------ C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis -------------------KSGSKEEPIV------------------------------- 5306_Tthe ------------------------------------------------------------ 5356_Tthe ------------------------------------------------------------ 5655_Tthe ------------------------------------------------------------ DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin DHPPPTVVPPLDDHIPKQPRTPASADPPISSPPSAFSSSTRKARKRTSDEFELDQTGALV AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam --------------------SAAVAR---------------------------------- GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele -Y------------HSQ------------------------------------------- C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis ---------------------------------------------------------SSS 5306_Tthe -QQ---------SQYSN------------------------------------------- 5356_Tthe -QR---------DSKQS------------------------------------------- 5655_Tthe -QQ---------S---T------------------------------------------- DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin SKRGSLKEKSRDDARASIRKHRSLNVSTSSSTSPRDSKTRERKRESIGLGLAISSSVVSP AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele ------------------------------------------------------------ C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis KSS-------SNSSSINNNFNNLYSASTFSSSTKKV------------------------ 5306_Tthe ------------------------------------------------------------ 5356_Tthe ------------------------------------------------------------ 5655_Tthe ------------------------------------------------------------ DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin RLAERHSRQAS------------------SS---SVSSPSSEPAPARRVHTTDFSHLPPS AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele ------------------------------------------------------------ C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis -----------HERPSINPG---------------------------------------- 5306_Tthe ------------------------------------------------------------ 5356_Tthe ------------------------------------------------------------ 5655_Tthe ------------------------------------------------------------ DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin PSSSSIQQFLRQTIPKEPPSLHSPPNVAHSLLRGTQEGWSGLDDEATAEALRKLDGLTGK AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele ------------------------------------------------------------ C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis ---------------------------------------------------FRKPREALL 5306_Tthe ------------------------------------------------------------ 5356_Tthe ------------------------------------------------------------ 5655_Tthe ------------------------------------------------------------ DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin TARSRASMTSLGRGSSASRPGTPAKSSQQWEGISGSESVRSKRISTFIREGGKEPRSTPN AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ---------------------------------------------------ARRPYKIGP GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele ------------------------------------------------------------ C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis S--------------GNSDSGIIKKPSS---SSTSSSSS--------------------- 5306_Tthe ------------------------------------------------------------ 5356_Tthe ------------------------------------------------------------ 5655_Tthe ------------------------------------------------------------ DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin PSEGALDSDYVAVSVSGAISSDEPHIIQDKTPKKQSRLSFTPKRGSTSSTTYGSTPTTSS AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam T--------------GTSGTNLIFAPAS---SI--------------------------- GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele ------------------------------------------------------------ C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe ------------------------------------------------------------ 5356_Tthe ------------------------------------------------------------ 5655_Tthe ------------------------------------------------------------ DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin RDSAGTATTNATSVSATSGGRVSSTKARRNSAGSDVSSVHSNDLTLLKDRAAHLAATGEL AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele ------------------------------------------------------------ C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe ------------------------------------------------------------ 5356_Tthe ------------------------------------------------------------ 5655_Tthe ------------------------------------------------------------ DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin IDDAHVPPVPPLPKDLSSYRSPPTTSSTQTFRSIPSVEDPDIRISQDSDIERAFSSDVSA AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel -----------------Q------------------------------------------ DYRK4_Mmus ----------L------QKPSS--------------KN---------------------- DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus -----------------G------------------------------------------ mbk-2_Cele ----------N------SLPPNLLGSSQNSASSNSLV----------------------- C36B7.2_Cele -----------------K------------------------------------------ C36B7.1_Cele -----------------R------------------------------------------ DYRK4_Hsap ----------I------QKPPS--------------NI---------------------- DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap -----------------G------------------------------------------ Dyrk2_Ddis ---SSSTTSNI------KAPIQ--------------I----------------------- 5306_Tthe ----------V------LNLLM-----------------------------QQQPTQPPQ 5356_Tthe ----------I------KQPKL--------------TLNTSSHNNTCNLSNNQSFAQST- 5655_Tthe ----------V------LQPSI--------------D--------------IQQYKQPNQ DYRK2_Spur -----------------T------------------------------------------ DYRK4_Spur ----------A-------SQPI--------------QI---------------------- CC1G_13957_Ccin GKGPRVGSS-A------TRQSQ--------------A----------------------- AqueK112_Aque ----------Y------NAPPL--------------SI---------------------- AqueK113_Aque -----------------KDPIV--------------D----------------------- DYRK2_b_Smoe ----------V------QTPSK--------------D--------------WET------ DYRK2_a_Smoe ----------V------QTPSK--------------D--------------WET------ GK034_Glam ------VHKAV------SVPKQ--------------Y----------------------- GK033_Glam ----------E------KIQSR--------------D--------------FEPHN---- GK032_Glam ----------LLVTYGFT------------------------------------------ smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel --------------------------------Y-----------LT------R------C DYRK4_Mmus --------------------------------KKL--------RVN------R------- DYRK3_Mmus --------------------------------D-----G--VY-DT------F------M DYRK2_Mmus --------------------------------A-----G--AP-RS------G------V mbk-2_Cele ------------------QGHRNPAL-----GS-----G--NT-LT------R------S C36B7.2_Cele --------------------------------G-----G--V------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap --------------------------------KNS--------RMT------Q------- DYRK3_Hsap --------------------------------D-----G--VY-DT------F------M DYRK2_Hsap --------------------------------A-----G--AT-RS------G------V Dyrk2_Ddis ----------------------SH----------SSNSG--SS-SSGGNNNNS------- 5306_Tthe QHQQIYQNLNNSQQYTTMQQ----SSG--QNY---------------------------- 5356_Tthe KHYQGNSSIHISGEKTLTQPNVNPSG-----G---------------------------- 5655_Tthe KKRDLVLTLKKSTEN----------LADSFI----------------------------- DYRK2_Spur --------------------------------A-----L--YP----------------- DYRK4_Spur --------------------------------NGV---LG-RR--T------NG-----L CC1G_13957_Ccin ----------------------NP----------NTSEA--------------------- AqueK112_Aque --------------------------------NSV----G-RSKVT------MG-----M AqueK113_Aque ---------------------FDP--------E-----G--IP-KT------T------T DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam ------------------------------------------------------------ GK032_Glam --------------------------------E-----GDSVHIKT------FTQCNDAL smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus MIDETK------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele -----YHQPSSTNSST------------NNLY---------------------------- C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap MIDETK------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis --------------------------------------------------------DDNS 5306_Tthe ---------------SNQ-SFTTNRQNSNANYL-----YHQLNPPQSTKAADSNRRQNNP 5356_Tthe ---------------INT-NTASNVNNSNSLII-----NHILDSTKSQGGTININANNIS 5655_Tthe -----------------NSCNITQNGSTKSSYVRNNKITQENIAPQQAQNNEP------S DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin ------------------------------------------------------------ AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam IP-EKK------------------------------------------------------ GK032_Glam LVTGSS------------------------------------------------------ smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel -----------------------------------------------------------F DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus -----------------------------------------------------------G DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele -----------GPLG-------------------------------TISRDLKQSIRDIS C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap -----------------------------------------------------------C DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis --GSSTIKH--------------------------------------------------- 5306_Tthe FSGTYSTKNTSAPQQLLKDILSKINKEQVQQQLPYQQNQQVLRSSHMM----NNS---QN 5356_Tthe FHNQYNITNL----------------------------------VSQM----NRK---RQ 5655_Tthe YDEEYI--------------------------SDAK-------FISQI----NRT---KK DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin ------------------------------------------------------------ AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque -----------------------------------------------------------M DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam -----------------------------------------------------------G GK032_Glam -----------------------------------------------------------I smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------EPLA-- DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------PPYS-- DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele ------------------------------------------------------PPVINS C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------PPCS-- DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe NSNSNVVILNN---NTQNANNQNIYSSNYVNTNPDLSNIYNPNNLAA-M-----NPQPSS 5356_Tthe PIGGNVIVNNSVGQNTMISNNINQLSANVQN----LNNILNYQNSGASTATNSNAPRSIQ 5655_Tthe ------------------------------------------------------PPQPKK DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin ------------------------------------------------------------ AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------TPAQE- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam L----------------------------------------------------------- GK032_Glam ------------------------------------------------------EPTV-- smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele S--------ANPHL----------------------V----------------------- C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe TKSNRIHSHYFPATTKNKSNRNPSLDKLNDSSFLRLKNVQSPKQRTIRTIMPGSNRDNSV 5356_Tthe -----FHQYGAPNST--------------------------------------------- 5655_Tthe G------------------ATVPTNQSI--------NNLQSAQQ----ELQLNYN-NNNI DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin ------------------------------------------------------------ AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele ------------------------------------------------------------ C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe GNNSSINRNGYFQREYSESGVDASNQYILPASLLQQK----TKRSGNSITGGVNNVIANN 5356_Tthe ------------------------------------------------------------ 5655_Tthe KNGKKI----------------------------SRYGEEYSKRQSFQMNGGKQMYCHNE DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin ------------------------------------------------------------ AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele ----------------------------------------------------NYVQTSSF C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe NNSYNNGSYSKIQPHLPQNQTRQNGTPYVKKDLTIKTGNSIETLKDILSPTNN------- 5356_Tthe ----------------------------------------------------N------- 5655_Tthe QLQIDKCETINIPSHIYSK-------------------------------STN------- DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin ------------------------------------------------------------ AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ----------------------------M--------------LN--------------- DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ----------------------------D--------------TF--------------- DYRK2_Mmus ---------------G------------T--------------GP--------------- mbk-2_Cele DNGSYEFPSGQAQQQR------------R--------------LG--------------- C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ----------------------------N--------------VL--------------- DYRK2_Hsap ---------------G------------T--------------GP--------------- Dyrk2_Ddis ----------------------------TAASLSKMKLSPSHTISDSPRSSTMKSRSVSI 5306_Tthe ------------------------------------------------------------ 5356_Tthe ------------------------------------------------------------ 5655_Tthe ------------------------------------------------------------ DYRK2_Spur ---------------H------------H--------------GH--------------- DYRK4_Spur ---------------Q------------S---------------E--------------- CC1G_13957_Ccin ------------------------------------------------------------ AqueK112_Aque ---------------S------------S---------------T--------------- AqueK113_Aque ---------------T------------K--------------MF--------------- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ----------------------------------------KHYA---------------- GK033_Glam ---------------GLATRGTIAAAEAA--------------DP--------------- GK032_Glam ----------------------------D--------------VL--------------- smi35A_Dmel -------------------------GS----------RLD-----------L--PQL-C- Dyrk3_Dmel -------------------------DS----------KED-----------F--PTQ-P- DYRK4_Mmus ---------------------------------------------------C--PQK-I- DYRK3_Mmus -------------------------SN----------PSE-----------A--PVS-R- DYRK2_Mmus -------------------------PS----------PIA-----------L--PPL-R- mbk-2_Cele -------------------------GS----------QQH-----------L--APL-Q- C36B7.2_Cele ---------------------------------------ATNGKQHHEWQRV--MTM-R- C36B7.1_Cele --------------------------------------------------MI--VPA-R- DYRK4_Hsap ---------------------------------------------------V--FHK-N- DYRK3_Hsap -------------------------CN----------PSE-----------P--PPP-R- DYRK2_Hsap -------------------------PS----------PIA-----------L--PPL-R- Dyrk2_Ddis SNGSLFSPTNTSVNNSNNNTSSNIKTPTKS-SISENLDQN-----------TP-PPPSSS 5306_Tthe ------------------------------------------------------------ 5356_Tthe ------------------------------------------------------------ 5655_Tthe ------------------------------------------------------------ DYRK2_Spur -------------------------GS----------HVE-----------L--PPI-K- DYRK4_Spur -------------------------KL----------SNS-----------L--PPA-S- CC1G_13957_Ccin --------------------VPIVKTPSKKWSFSSALNLK-----------LASSPSSSS AqueK112_Aque -------------------------GV----------SMA-----------T--RPS--- AqueK113_Aque -------------------------SG----------AVT-----------L--PPL-L- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------RDP----------DDK-----------I--EPF-SA GK033_Glam -------------------------YP----------KVP-----------V--PTM-S- GK032_Glam -------------------------QT----------HQD-----------P--PLP-Q- smi35A_Dmel ---------NGSR----------------------------------------------- Dyrk3_Dmel ---------SN------------------------------------------------- DYRK4_Mmus ---------PSNT----------------------------------------------- DYRK3_Mmus ---------RLNI----------------------------------------------- DYRK2_Mmus ---------ASNA----------------------------------------------- mbk-2_Cele ---------QTAS----------------------------------------------- C36B7.2_Cele ----------LDR----------------------------------------------- C36B7.1_Cele ----------V-S----------------------------------------------- DYRK4_Hsap ---------TSVT----------------------------------------------- DYRK3_Hsap ---------RLNM----------------------------------------------- DYRK2_Hsap ---------ASNA----------------------------------------------- Dyrk2_Ddis STTKTPTATTTTT----------------------------------------------- 5306_Tthe ---------NANP----------------------------------------------- 5356_Tthe ---------KVNS----------------------------------------------- 5655_Tthe ---------HSA------------------------------------------------ DYRK2_Spur ---------SH------------------------------------------------- DYRK4_Spur ---------SGQT----------------------------------------------- CC1G_13957_Ccin TKSSFPL----------------------------------------------------- AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ---------KSSS----------------------------------------------- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam AASKDTTSKGSSV----------------------------------------------- GK033_Glam ---------ASEKQVLSRKITPRALKEFIELKRRIIRLLTQRVAPEADVTVKLLDVLGSF GK032_Glam ---------EINI----------------------------------------------- smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele ------------------------------------------------------------ C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe ------------------------------------------------------------ 5356_Tthe ------------------------------------------------------------ 5655_Tthe ------------------------------------------------------------ DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin ------------------------------------------------------------ AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam KGLVESVPTDDGVPLWTFDWGSAVYFSEHNIGSAASDLNARYIRPQSKAISKRAGSRIIT GK032_Glam ------------------------------------------------------------ smi35A_Dmel ----------------------------------------------------------R- Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ----------------------------------------------------------A- DYRK3_Mmus ----------------------------------------------------------T- DYRK2_Mmus ----------------------------------------------------------T- mbk-2_Cele ----------------------------------------------------------S- C36B7.2_Cele ----------------------------------------------------------F- C36B7.1_Cele ----------------------------------------------------------Y- DYRK4_Hsap ----------------------------------------------------------S- DYRK3_Hsap ----------------------------------------------------------T- DYRK2_Hsap ----------------------------------------------------------A- Dyrk2_Ddis ----------------------------------------------------------T- 5306_Tthe ----------------------------------------------------------K- 5356_Tthe ----------------------------------------------------------S- 5655_Tthe ------------------------------------------------------------ DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ----------------------------------------------------------T- CC1G_13957_Ccin ----------------------------------------------------------S- AqueK112_Aque ----------------------------------------------------------R- AqueK113_Aque ----------------------------------------------------------N- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ----------------------------------------------------------T- GK033_Glam MRAQPSAESPDPGPEQQYVVERSSHYPNVFFMRKSRAYSQAFQALVPSAAPVTLLQSAL- GK032_Glam ----------------------------------------------------------TQ smi35A_Dmel -----------------------------------------------------LD----- Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus -----------------------------------------------------FPF---- DYRK3_Mmus -----------------------------------------------------TEP---- DYRK2_Mmus -----------------------------------------------------TTA---- mbk-2_Cele -----------------------------------------------------LYSNPQS C36B7.2_Cele -----------------------------------------------------FPV---- C36B7.1_Cele -----------------------------------------------------FPS---- DYRK4_Hsap -----------------------------------------------------LPF---- DYRK3_Hsap -----------------------------------------------------TEQ---- DYRK2_Hsap -----------------------------------------------------AAA---- Dyrk2_Ddis -----------------------------------------------------TTT---- 5306_Tthe -----------------------------------------------------TTT---- 5356_Tthe -----------------------------------------------------FNQ---- 5655_Tthe ------------------------------------------------------------ DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur -----------------------------------------------------FPQ---- CC1G_13957_Ccin -------PRSVGFGHGLRKSSSKEQTSSASSSKAPWSPEQPDAMASAGS----LAS---- AqueK112_Aque -----------------------------------------------------HPT---- AqueK113_Aque -----------------------------------------------------KTV---- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam -----------------------------------------------------TQP---- GK033_Glam -----------------------------------------------------NAS---- GK032_Glam NIMGDQAISMVVEGKKQLRDTCMTCDAGDFDRCLSSSKHHPSADVAVSSTAKVVPS---- smi35A_Dmel ---------------------------------------------------G------HN Dyrk3_Dmel -----------------------------------------------N-I-A-------- DYRK4_Mmus --V--------------------------------------------D--------TKGK DYRK3_Mmus --L--------------------------------------------T-R-G------HT DYRK2_Mmus --H--------------------------------------------T-I-G------GS mbk-2_Cele SSS--------------------------------------------QLL-G------QQ C36B7.2_Cele --Y--------------------------------------------D--------HRAR C36B7.1_Cele --F--------------------------------------------R--------AWNR DYRK4_Hsap --V--------------------------------------------D--------TKGK DYRK3_Hsap --F--------------------------------------------T-G-D------HT DYRK2_Hsap --H--------------------------------------------T-I-G------GS Dyrk2_Ddis -------------------------------------------------S------SSSS 5306_Tthe --A--------------------------------------------T-K-D------SK 5356_Tthe --F--------------------------------------------N-QGG------QT 5655_Tthe ------------------------------------------------------------ DYRK2_Spur -----------------------------------------------T-I-G------AV DYRK4_Spur --L--------------------------------------------S-L-G-----HNK CC1G_13957_Ccin -------------------------------------------------L------SSLG AqueK112_Aque --S--------------------------------------------S-V-E----TRDR AqueK113_Aque --K--------------------------------------------------------- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam --M--------------------------------------------S-S------QRSK GK033_Glam --K--------------------------------------------R-I-GPLEEDT-S GK032_Glam --VNATELVLMSDTAQAQSPTEEFYPIPATTIPCEFKPLNAVYLAYHD-I-V------AT smi35A_Dmel N-----HVAA------------------------------------------------NE Dyrk3_Dmel --------------------------------------------------------NYP- DYRK4_Mmus R-----NTV-----------------------------------------NF----PQI- DYRK3_Mmus Q-----HFVN------------------------------------------------G- DYRK2_Mmus K-----HTMND---------------------------------------HLHLN--SH- mbk-2_Cele QAVRPNYAYQQ---------------------------------------SLPRQQHIN- C36B7.2_Cele R-----EPLHL---------------------------------------SL----PMT- C36B7.1_Cele K-----EA---------------------------------------------------- DYRK4_Hsap K-----NTV-----------------------------------------SF----PHI- DYRK3_Hsap Q-----HFLD------------------------------------------------G- DYRK2_Hsap K-----HTMND---------------------------------------HLHVGSHAH- Dyrk2_Ddis T-----STN-----------------------------------------TT----PS-- 5306_Tthe K-----HLNS----------------------------------------NTL-PIQSY- 5356_Tthe N-----NFMN---------------------------------------------LSSV- 5655_Tthe --------SK----------------------------------------GTKSP----- DYRK2_Spur K-----KT-NE---------------------------------------------NVP- DYRK4_Spur S-----NTMGE---------------------------------------SL----PQL- CC1G_13957_Ccin S-----V----------------------------------------------------- AqueK112_Aque S-----GT-VP---------------------------------------SL----PQV- AqueK113_Aque D-----TTFAE---------------------------------------AL----PRL- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam T-----TSV-----------------------------------------RQ----PK-- GK033_Glam D-----TTTLN------------------------------------SLAAI----PTA- GK032_Glam E-----NVLQNGKLGPTPFSYFYDRTLKVDSNCERVGYTMYPACSDYWVKHRHSGNDAL- smi35A_Dmel N--------------------------------TVT---TTSLNGN--------G----- Dyrk3_Dmel G--------------------------------DIQ---ILPIFD---------C----- DYRK4_Mmus GN-----------------------------KVPSK------------------------ DYRK3_Mmus S--------------------------------EMK---VEQLFQ---------E----- DYRK2_Mmus G--------------------------------QIQ---VQQLFE---------D----- mbk-2_Cele S--------------------------------H-Q---TQAFFG---------TVRGPT C36B7.2_Cele ----------------------------------LSN----------------------- C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap SK-----------------------------KVLLK------------------------ DYRK3_Hsap G--------------------------------EMK---VEQLFQ---------E----- DYRK2_Hsap G--------------------------------QIQ---VQQLFE---------D----- Dyrk2_Ddis ---------------------------------KSS---VDDVFA---------R----- 5306_Tthe T--------------------------------TTH---AQQIHQQKRLLQKRDD---QK 5356_Tthe S--------------------------------------TSQNAQ-VNNSQHINN---NN 5655_Tthe ------------------------------------------------------------ DYRK2_Spur T--------------------------------GLQ---VTQLFE---------T----- DYRK4_Spur TN-----------------------------VQG-------------------------- CC1G_13957_Ccin ------------------------------------------------------------ AqueK112_Aque GN-----------------------------VKDGKS--RDQTWD---------I----- AqueK113_Aque S--------------------------------GVQ---VQPMFR---------D----- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ----------------------------------AV---TQTLYQ---------Q----- GK033_Glam ---------------------------------------ASSLQT---------T----- GK032_Glam GNESTDEYSQPDDPGRIVYTYDYDNDNILNSTFEIELHSFAQVMQ---------E----- smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele NST------------------N----------------------------------IVTP C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe NKS------------------NFINSSFQ--------------------------YIMAS 5356_Tthe NGSNPIRRSKYKINTETINTQN------DYSLTIDHSGGSIPRYPQTETHKTGTKEIIIP 5655_Tthe ------------------------------------------------------------ DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin ------------------------------------------------------------ AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele --LRASKTMIDV------------------------------------------------ C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe ENNS-----VENTNRFSYNVMNNMVANNQGQKLLKNKNNSMENQQFKNLSFTQPLN---- 5356_Tthe QSNK-----IEQI--------------------SN-RY--------NLTSTNKPNSRMHL 5655_Tthe ------------------------------------------------------------ DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin ------------------------------------------------------------ AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel ------------------NGNGN--SN--------------------------------- Dyrk3_Dmel ------------------CEISE-SI---------------------------------- DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------FGNRR------------------------------------- DYRK2_Mmus ------------------NSNKR-TVL--------------------------------- mbk-2_Cele ------------------LAPVR-DTV--------------------------------- C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------FGNRK------------------------------------- DYRK2_Hsap ------------------NSNKR-TVL--------------------------------- Dyrk2_Ddis ------------------LANVSKPAIKSRSL---------------------------- 5306_Tthe ----------------DQF----------------------------------------- 5356_Tthe MIGTENDQSQNQMGGLKDF----------------------------------------- 5655_Tthe ------------------------------------------------------------ DYRK2_Spur ------------------DDNHN-FKR--------------------------------- DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin ---------------------------RNHSLHPDTSKTPDKNRPGTGSSVSTAGLSAPS AqueK112_Aque ------------------YGDTE-QLL--------------------------------- AqueK113_Aque ------------------QVPLN-DLQ--------------------------------- DYRK2_b_Smoe ------------------F----------------------------------------- DYRK2_a_Smoe ------------------F----------------------------------------- GK034_Glam ------------------QQE--ASLL--------------------------------- GK033_Glam ------------------MGQQL------------------------------------- GK032_Glam ------------------MG---------------------------------------- smi35A_Dmel -------------------------------------SN--------------------- Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus --------------------------------------G--------------------- DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus -------------------------------------TT--------------------- mbk-2_Cele -------------------------------------A---------------------- C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap --------------------------------------S--------------------- DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap -------------------------------------TT--------------------- Dyrk2_Ddis ---SVSASLAR----------VEQSPPTKDKGDKESSSSSSSS--------------SSS 5306_Tthe --------------------------------------K--------------------- 5356_Tthe --------------------------------------L--------------------- 5655_Tthe ------------------------------------------------------------ DYRK2_Spur -------------------------------------QV--------------------- DYRK4_Spur -----------------------------------HLVA--------------------- CC1G_13957_Ccin GPLSPSASIKRAQSKRLTPSSI----PFFR---RSS------SQSMQVPSSSGSGHPSSP AqueK112_Aque -------------LSPYSSRPRPSPSLIPRLKPSGSCRR--------------------- AqueK113_Aque -------------------------------------QR--------------------- DYRK2_b_Smoe --------------------------------------M--------------------- DYRK2_a_Smoe --------------------------------------M--------------------- GK034_Glam ------------------------------HGNKL----------------------GAN GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel -----N--N-------------NNIG-S--P-V--------------------------- Dyrk3_Dmel -----Q--A-------------I-S--L--P-N--------------------------- DYRK4_Mmus -----PM---------------Q-Y--Q--E----------------------------- DYRK3_Mmus ------S-N-------------T-L--Q--S-D--------------------------- DYRK2_Mmus -----Q------------------------P-N--------------------------- mbk-2_Cele ------------------------A--Q--A-T--------------------------- C36B7.2_Cele ----------------------S-YRYQLTA-R--------------------------- C36B7.1_Cele -----------------------------SM-N--------------------------- DYRK4_Hsap -----SL---------------L-Y--Q--E----------------------------- DYRK3_Hsap ------S-N-------------T-I--Q--S-D--------------------------- DYRK2_Hsap -----Q------------------------P-N--------------------------- Dyrk2_Ddis FSSKFTKILRSSSKTPTPTSSNTTV--Q--PSTTSLSASKISSRKDTKSL-SSFSTTT-- 5306_Tthe -----Q------------------------------------------------------ 5356_Tthe -----S------------------------P-Q--------------------------- 5655_Tthe ------------------------------------------------------------ DYRK2_Spur -----Q--N-------------K-V--I--A-N--------------------------- DYRK4_Spur -----SG---------------I-H--Q--TTI--------------------------- CC1G_13957_Ccin PPSMPTKASRSKASTPPHD----------------ISMTSVST-PGKKASVLSLGLPSLL AqueK112_Aque -----SP---------------S-K--Q--TTA--------------------------- AqueK113_Aque -----RP-R-------------Q-S--T--A-D--------------------------- DYRK2_b_Smoe -----T------------------------P-E--------------------------- DYRK2_a_Smoe -----T------------------------P-E--------------------------- GK034_Glam YAGKNQPIVYIKSKPPSTTNSRT-T--T--PKR--------------------------- GK033_Glam -----S--S-------------T-L--QE-S-Q--------------------------- GK032_Glam ------S-N-------------P-L--G--T-D--------------------------- smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele ------------------------------------------------------------ C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe ------------------------------------------------------------ 5356_Tthe ------------------------------------------------------------ 5655_Tthe ------------------------------------------------------------ DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin KSSSRRSLHSDAKEAAKELQKAKEAARESDREKAKAEKAEKERQKKEDKDRSESRISVLI AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel --------------------------------------------------------S--- Dyrk3_Dmel --------------------------------------------------------V--- DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus --------------------------------------------------------GI-- DYRK2_Mmus --------------------------------------------------------GL-- mbk-2_Cele --------------------------------------------------------GL-- C36B7.2_Cele --------------------------------------------------------NM-- C36B7.1_Cele --------------------------------------------------------HL-- DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap --------------------------------------------------------GI-- DYRK2_Hsap --------------------------------------------------------GL-- Dyrk2_Ddis ------------------------------------------------TTTTLKSSSS-- 5306_Tthe ----------------------------------------------------------TK 5356_Tthe --------------------------------------------------------GAAF 5655_Tthe ----------------------------------------------------------FQ DYRK2_Spur --------------------------------------------------------GH-- DYRK4_Spur --------------------------------------------------------GE-- CC1G_13957_Ccin SRKRGKTLSATDPRKPKSPVTLPPMQISAIEPVTAQRVAKLKSSSSQSTTSSINSRTSS- AqueK112_Aque --------------------------------------------------------GA-- AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe --------------------------------------------------------GK-- DYRK2_a_Smoe --------------------------------------------------------GK-- GK034_Glam --------------------------------------------------------GA-- GK033_Glam --------------------------------------------------------GI-- GK032_Glam --------------------------------------------------------DL-- smi35A_Dmel ------SS-----T----------T----------------------------------- Dyrk3_Dmel ----T-SP-----S----------KT---------------------------------- DYRK4_Mmus ------NQ-----I----------H----------------------------------- DYRK3_Mmus ----S-NS-----E----------K----------------------------------- DYRK2_Mmus ----T-TV-----G----------K----------------------------------- mbk-2_Cele ----P-NV-----G----------TSSSNGSSNSSSGVGSGGSGSLMTQSIGGPNKHLSA C36B7.2_Cele ----S-CS-----M----------T----------------------------------- C36B7.1_Cele -------T-----L----------S----------------------------------- DYRK4_Hsap ------NQ-----A----------H----------------------------------- DYRK3_Hsap ----S-DS-----E----------K----------------------------------- DYRK2_Hsap ----T-TV-----G----------K----------------------------------- Dyrk2_Ddis ----S-SSSSSSSS----------K----------------------------------- 5306_Tthe ENNNT-QN-----S---------------------------------------------- 5356_Tthe ---IK-SN-----V---------------------------------------------- 5655_Tthe INPTP-TN-----S---------------------------------------------- DYRK2_Spur ----L-SH-----D----------A----------------------------------- DYRK4_Spur ----HIK------A----------H----------------------------------- CC1G_13957_Ccin ----S-SSRVTSQT----------A----------------------------------- AqueK112_Aque ----SVPD-----P----------H----------------------------------- AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ----S-TS-----T----------R----------------------------------- GK033_Glam ----F-GL-----S----------S----------------------------------- GK032_Glam ----L-PV-----EKPAVALGDQYT----------------------------------- smi35A_Dmel -----------------------------N---S-------------------------- Dyrk3_Dmel -----------------------------K---D-------------------------- DYRK4_Mmus -----------------------------N---Q-------------------------- DYRK3_Mmus ---------------------------------S-------------------------- DYRK2_Mmus -----------------------------T---G-------------------------- mbk-2_Cele SHSTLNTASTHDMMH--------------S---K-------------------------- C36B7.2_Cele -----------------------------A---R-------------------------- C36B7.1_Cele -----------------------------R---W-------------------------- DYRK4_Hsap -----------------------------N---Q-------------------------- DYRK3_Hsap ---------------------------------C-------------------------- DYRK2_Hsap -----------------------------T---G-------------------------- Dyrk2_Ddis -----------------------------S---NIASSSSSSSNNLTNLLTQSQS----- 5306_Tthe --------------N--------------N---K-------------------------- 5356_Tthe --------------SSKSTQRNYSNKNRYL---G-------------------------- 5655_Tthe --------------N--------------N---N-------------------------- DYRK2_Spur -----------------------------N---A-------------------------- DYRK4_Spur -----------------------------R------------------------------ CC1G_13957_Ccin -----------------------------S---SMQKISDSSLRSRTQLPTI-AGSPSVG AqueK112_Aque -----------------------------S-RGR-------------------------- AqueK113_Aque ---------------------------------T-------------------------- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam -----------------------------S---ERTASTS-------------------- GK033_Glam -----------------------------TNPLQ-------------------------- GK032_Glam -----------------------------T---V-------------------------- smi35A_Dmel ------------------------------------SNG--G------------------ Dyrk3_Dmel ------------------------------------VPG--L------------------ DYRK4_Mmus ------------------------------------VLS--S------------------ DYRK3_Mmus ------------------------------------SPA--------------------- DYRK2_Mmus ------------------------------------LPG--V------------------ mbk-2_Cele ------------------------------------IPK--S------------------ C36B7.2_Cele ------------------------------------EPA--DL----------------- C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------MPA--S------------------ DYRK3_Hsap ------------------------------------SPT--V------------------ DYRK2_Hsap ------------------------------------LPV--V------------------ Dyrk2_Ddis ------------------ISSTSTSTTTTPTS---TSPT--LAS---------------- 5306_Tthe ------------------------------------ILT--V------------------ 5356_Tthe ------------------------------------LNK--I------------------ 5655_Tthe ------------------------------------NSK--K------------------ DYRK2_Spur ------------------------------------LPD--V------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin TNGTNSTQNTIREKDHSSLLSSSI--SGLPKETPTKIPR--ISSRTSAAPSPSGKSTSTF AqueK112_Aque -----------------------------------LYRS--T------------------ AqueK113_Aque ------------------------------------LPN--L------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam -----------------------------------VSPR--AVA---------------- GK033_Glam ------------------------------------VPSQVQ------------------ GK032_Glam ------------------------------------TPT--S------------------ smi35A_Dmel ---------------------------------------------------------N-- Dyrk3_Dmel ---------------------------------------------------------F-- DYRK4_Mmus ---------------------------------------------------------E-- DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ---------------------------------------------------------P-- mbk-2_Cele ---------------------------------------------------------P-- C36B7.2_Cele ---------------------------------------------------------R-- C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ---------------------------------------------------------E-- DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ---------------------------------------------------------P-- Dyrk2_Ddis -------------------------------------------SMSVLSS-------P-- 5306_Tthe ---------------------------------------------------KQQQ--Q-- 5356_Tthe ---------------------------------------------------QAQQQNS-- 5655_Tthe ---------------------------------------------------------P-- DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin ASRRTSMNPAASSSTNPSPISLSTNEFGVIDNEDGATPRNLARQSSIRASPSTSASRP-- AqueK112_Aque ---------------------------------------------------------S-- AqueK113_Aque ---------------------------------------------------------H-- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam -------------------------------------------TKLSQRT-------P-- GK033_Glam ---------------------------------------------------------PKM GK032_Glam ---------------------------------------------------------P-- smi35A_Dmel -------E-------------------------------------RGS-------S--T- Dyrk3_Dmel -------L-------------------------RTISENSKSKSEP---------E--C- DYRK4_Mmus -------L-------------------------------------K-T------SE--I- DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus -------E-------------------------------------R---------Q--L- mbk-2_Cele -------S-------------------------------------N-------------- C36B7.2_Cele -------E-------------------------------------D---------S--F- C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap -------L-------------------------------------K-A------SE--I- DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap -------E-------------------------------------R---------Q--L- Dyrk2_Ddis -------T-------------------------------------S---------T---- 5306_Tthe -------K--------------------QQ--LQFIQKG-LGQ----------------- 5356_Tthe -------S--------------------QSRVRSNIKQMSKDK----------------- 5655_Tthe -------K--------------------LS--LNSVHLNNRAS----------------- DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin -------ARQSSANTSSTSSSALRKSTRES--VSFIGLR-KASTSS---------V---- AqueK112_Aque -------L-------------------------------------R-SDSDLDGDS--L- AqueK113_Aque -------H-------------------------------------N---------R--P- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam -------S-------------------------------------S---------K--G- GK033_Glam GVLASKIR-------------------------------------N---------QHSL- GK032_Glam -------Q-------------------------------------A---------H--GD smi35A_Dmel K--SN-S-SSGS------------------------------------------------ Dyrk3_Dmel E--SL-I-S-VKE------SSVMENHTFLFH----------------------------- DYRK4_Mmus P--F----N-IN------------------------------------------------ DYRK3_Mmus ---SQ-G-K-SS------------------------------------------------ DYRK2_Mmus E--SI-H-R-RQ------------------------------------------------ mbk-2_Cele E--SL-S-R-SH------------------------------------------------ C36B7.2_Cele K--RI-V-R-KR------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap P--F----H-PS------------------------------------------------ DYRK3_Hsap ---SQ-G-K-SS------------------------------------------------ DYRK2_Hsap D--SI-H-R-RQ------------------------------------------------ Dyrk2_Ddis ----------TT------------------------------------------------ 5306_Tthe ---NS-------SKQN---QS------SIQTS------EGNENKSESNYESQGQNLDNFD 5356_Tthe ---AL-------SV--DKTSN------YINRRDSTQNQNGNYI----------------- 5655_Tthe ---SF-------SVEDENQVK------FMKNV------ESFTNQQQTKLKSLRQILNDTT DYRK2_Spur -----------K------------------------------------------------ DYRK4_Spur --------Q-PN------------------------------------------------ CC1G_13957_Ccin ----------NS------------------------------------------------ AqueK112_Aque PIPGIGG-V-PA------------------------------------------------ AqueK113_Aque L--TS-A-Q-P------------------------------------------------- DYRK2_b_Smoe ---TI------------------------------------------------------- DYRK2_a_Smoe ---TI------------------------------------------------------- GK034_Glam R--GV-V-A-AT------------------------------------------------ GK033_Glam S--AE-ESR-MQ------------------------------------------------ GK032_Glam N--TI-A-E-VE------------------------------------------------ smi35A_Dmel -------------------------------------------------------GSSG- Dyrk3_Dmel -----------------------------------------------------EQIIMS- DYRK4_Mmus -------------------------------------------------------TKAQ- DYRK3_Mmus -------------------------------------------------------ESLS- DYRK2_Mmus -------------------------------------------------------GSST- mbk-2_Cele -------------------------------------------------------TSSSG C36B7.2_Cele ---------------------------------------------------------AQ- C36B7.1_Cele ----------------------------------------------------------Q- DYRK4_Hsap -------------------------------------------------------IKTQ- DYRK3_Hsap -------------------------------------------------------DCLN- DYRK2_Hsap -------------------------------------------------------GSST- Dyrk2_Ddis -------------------------------------------------------TSTS- 5306_Tthe QHKIDLSTASQTPFRNGNS------------------TNEKKTLD-----DNNTRNTERD 5356_Tthe QDKSSLLQTLQPPASQSYDQGGDNAYYKHNTLQDEQLGSTYYTIDNQNLQQPTIQSSGSS 5655_Tthe ---------------------------------------------------DQRQNT-HA DYRK2_Spur -------------------------------------------------------RP-A- DYRK4_Spur -------------------------------------------------------KFEE- CC1G_13957_Ccin -------------------------------------------------------TSTP- AqueK112_Aque -------------------------------------------------------AVPS- AqueK113_Aque -------------------------------------------------------QSMT- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam -------------------------------------------------------TTPA- GK033_Glam -------------------------------------------------------ASTK- GK032_Glam -------------------------------------------------------FTAD- smi35A_Dmel N-SA--SS---------------------------------TGSG--------------- Dyrk3_Dmel G-QQ--KC---------------------------------ELHE--------------- DYRK4_Mmus D-TK--PH---------------------------------PELQ--------------- DYRK3_Mmus A-VK--CN---------------------------------LSSR--------------- DYRK2_Mmus S-LK--SM---------------------------------EGMG--------------- mbk-2_Cele G-SQ--GG---------------------------------HNSN--------------- C36B7.2_Cele N-HC--VD---------------------------------QTVY--------------- C36B7.1_Cele ---V--AG---------------------------------VSQQ--------------- DYRK4_Hsap D-PK--AE---------------------------------EKSP--------------- DYRK3_Hsap T-VK--SN---------------------------------SSSK--------------- DYRK2_Hsap S-LK--SM---------------------------------EGMG--------------- Dyrk2_Ddis T-TS--TT---------------------------------TTPT--------------- 5306_Tthe E-KK--EE---------------------------------PLDW--------------- 5356_Tthe K-LE--EK---------------------------------HLTW--------------- 5655_Tthe S-VI--ST---------------------------------NNDQ--------------- DYRK2_Spur S-DG--SK---------------------------------NGSA--------------- DYRK4_Spur I-KR--SS---------------------------------KNEG--------------- CC1G_13957_Ccin GTSGTTSE---------------------------------SSGSHRFSALSPSKGLKLL AqueK112_Aque T-SR--SR---------------------------------RNPQ--------------- AqueK113_Aque D-DA--SS---------------------------------DQSQ--------------- DYRK2_b_Smoe ------------------------------------------VYY--------------- DYRK2_a_Smoe ------------------------------------------VYY--------------- GK034_Glam D-QN--RS---------------------------------QLKG--------------- GK033_Glam E-NK-DSM---------------------------------KFRV--------------- GK032_Glam D-EG--AMDNSTDEQAPGYVPVGDNMDPGLIDQQVLHNAEAPGLN--------------- smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele ------------------------------------------------------------ C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe ------------------------------------------------------------ 5356_Tthe ------------------------------------------------------------ 5655_Tthe ------------------------------------------------------------ DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin GPKSSRSAASSSQNLRQNMSSPSSSRQSLSTPSPVPSTVDEDELLGDEEMMNYIRRQQAK AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel ----------------E---LKCNTP------------------MTPSELVK-KF-RN-Y Dyrk3_Dmel --------------------KPKVLV------------------VSPQQVMI-LY-MN-K DYRK4_Mmus --------------------KKHKVP------------------LTVAEALK-FF-KN-Q DYRK3_Mmus --------------------PSKVLP------------------LTPEQALK-QY-KH-H DYRK2_Mmus --------------------KVKASP------------------MTPEQAMK-QY-MQ-K mbk-2_Cele --------------------SGSNSG------------------FRPEDAVQ-TF-GA-K C36B7.2_Cele --------------------PNENPG------------------LSPSSIFN-GY-SH-L C36B7.1_Cele --------------------DEACSG------------------LIPQQASL-VY-LH-Q DYRK4_Hsap --------------------KKQKVT------------------LTAAEALK-LF-KN-Q DYRK3_Hsap --------------------APKVVP------------------LTPEQALK-QY-KH-H DYRK2_Hsap --------------------KVKATP------------------MTPEQAMK-QY-MQ-K Dyrk2_Ddis --------------------KSSCTI------------------ITPSIALK-LY-IN-D 5306_Tthe --------------------EKVKVP------------------ITPLEVLA-KY-QK-Y 5356_Tthe --------------------EDLKLP------------------VGPDDVLN-KY-GHEF 5655_Tthe --------------------LILN-T------------------ENTNNILT-QS-KE-N DYRK2_Spur --------------------KGRALP------------------MTPEESMK-LY-MH-K DYRK4_Spur --------------------KDSRGH------------------MKPNEAMM-YY-RD-K CC1G_13957_Ccin KKAAGATQEELEEMLKFPEPTPPVPP------------------ASPHHVLK-SSQAQ-Y AqueK112_Aque --------------------QSIRLP------------------MTPSQAIK-EY-GH-R AqueK113_Aque --------------------SQKQRY------------------LTPDQAIK-LY-GS-K DYRK2_b_Smoe --------------------STWLNC------------------FVRSAVLK-QY-PS-S DYRK2_a_Smoe --------------------STWLNC------------------FVRSAVLK-QY-PS-S GK034_Glam --------------------SAFPRE------------------ITAAEVLS-SH-KS-D GK033_Glam --------------------VQNATPSTTKVESVNYRDLIMEHLSSPQATIEAKL-Q-SA GK032_Glam --------------------REKAPE------------------HMPEAAFK-S-HIA-K smi35A_Dmel LTDLEFEE---------------LKVYK-EV---WYFGQ------HASKNYNKP------ Dyrk3_Dmel LTPYERTE---------------ILTYP-QI---YFIGA------NAKKRPG-------- DYRK4_Mmus LSPYEQSE---------------ILGYS-EL---WFLGL------EAKKLNV-------- DYRK3_Mmus LTAYEKLE---------------IVSYP-EI---YFVGP------NAKKRQG-------- DYRK2_Mmus LTAFEHHE---------------IFSYP-EI---YFLGP------NAKKRQG-------- mbk-2_Cele LVPFEKNE---------------IYNYT-RV---FFVGS------HAKKQAG-------- C36B7.2_Cele LSPFEKIE---------------VKKYG-KI---YALSM------NPETLKA-------- C36B7.1_Cele LTSYEKRE---------------IEDYP-IV---YTVGD------YGSKNQT-------- DYRK4_Hsap LSPYEQSE---------------ILGYA-EL---WFLGL------EAKKLDT-------- DYRK3_Hsap LTAYEKLE---------------IINYP-EI---YFVGP------NAKKRHG-------- DYRK2_Hsap LTAFEHHE---------------IFSYP-EI---YFLGL------NAKKRQG-------- Dyrk2_Ddis LTSAEQSE---------------ILDYP-QI---YFTGN------TNKKTKF-------- 5306_Tthe LTPQEKAE---------------ILEFK-RI---YFIGH------NANKA---------- 5356_Tthe LTDYEKKE---------------ILQYM-NI---YYVGH------KAKKPARSE------ 5655_Tthe LNIDINSE---------------IKDWALVI---YFIGH------QCKKKFQ-------- DYRK2_Spur LTSYEHHE---------------IFNYP-HI---YFTGP------NAKKRQG-------- DYRK4_Spur LTVFEEAE---------------ILDYQ-EV---WFLGP------EAKKVEG-------- CC1G_13957_Ccin LSDYERKE---------------ILDYP-SV---YFIGA------KSRKKMA-------- AqueK112_Aque LTGYEKKE---------------ILEYP-DV---WFLGL------ESKKIEG-------- AqueK113_Aque LSEFEQQE---------------IQAFQ-QV---YFVGQ------HAKKRQG-------- DYRK2_b_Smoe LTDFEKQE---------------ILKYP-EI---YYIGL------PQKKIQV-------- DYRK2_a_Smoe LTDFEKQE---------------ILKYP-EI---YYIGL------PQKKIQV-------- GK034_Glam LTPFEQSE---------------IQRFA-KI---YYWGQ------QANKQY--------- GK033_Glam LTADERQKFDSTVRSFAEKLRAKELSY-SSILSNLFDGL------SAPSGSQVQ------ GK032_Glam K--IEETE---------------RAVTP------YVVRKQSAIRHRDKDRQYIVTGDTMR : smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele ------------------------------------------------------------ C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe ------------------------------------------------------------ 5356_Tthe ------------------------------------------------------------ 5655_Tthe ------------------------------------------------------------ DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin ------------------------------------------------------------ AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam ------GSGRPGSNYGQSTSSLPTGIEQFSSRGDSDTRTDPSDHDFDSDMALSGNEEYED GK032_Glam ADVLQQI----------------------------------------------------- smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele ------------------------------------------------------------ C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe ------------------------------------------------------------ 5356_Tthe ------------------------------------------------------------ 5655_Tthe ------------------------------------------------------------ DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin ------------------------------------------------------------ AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam INLGDEDQAQFAASAGQVSIGNSVSMDSMIRTTNEFIKATSASGLSEQIESSAQSLQSTG GK032_Glam ------------------------------------------------------------ smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele ------------------------------------------------------------ C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe ------------------------------------------------------------ 5356_Tthe ------------------------------------------------------------ 5655_Tthe ------------------------------------------------------------ DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin ------------------------------------------------------------ AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam SLHRSDVHSSSVGALGHVGAHHIRPQSSKAVSSISSAMNMATSLYSQTQLSTGAPTQTAS GK032_Glam ------------------------------------------------------------ smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele ------------------------------------------------------------ C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe ------------------------------------------------------------ 5356_Tthe ------------------------------------------------------------ 5655_Tthe ------------------------------------------------------------ DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin ------------------------------------------------------------ AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam KNGSSDAPAVVYTPVPPMADDITKSCLRLEISVTSMDVAEAGGTAMSGKDEKVFQSSVPL GK032_Glam ------------------------------------------------------------ smi35A_Dmel -------------------AP--------------------------------------- Dyrk3_Dmel -------------------VY--------------------------------------- DYRK4_Mmus -------------------VP--------------------------------------- DYRK3_Mmus -------------------VI--------------------------------------- DYRK2_Mmus -------------------MT--------------------------------------- mbk-2_Cele -------------------VI--------------------------------------- C36B7.2_Cele -------------------PE--------------------------------------- C36B7.1_Cele -------------------NH--------------------------------------- DYRK4_Hsap -------------------AP--------------------------------------- DYRK3_Hsap -------------------VI--------------------------------------- DYRK2_Hsap -------------------MT--------------------------------------- Dyrk2_Ddis -------------------N---------------------------------------- 5306_Tthe ------------------------------------------------------------ 5356_Tthe -------------------IQ--------------------------------------- 5655_Tthe -------------------KT--------------------------------------- DYRK2_Spur -------------------VI--------------------------------------- DYRK4_Spur -------------------VQ--------------------------------------- CC1G_13957_Ccin -------------------TP--------------------------------------- AqueK112_Aque -------------------VP--------------------------------------- AqueK113_Aque -------------------VI--------------------------------------- DYRK2_b_Smoe -------------------VG--------------------------------------- DYRK2_a_Smoe -------------------VG--------------------------------------- GK034_Glam ------------------------------------------------------------ GK033_Glam LPVTAYCDINAVIDTAVSGLDASDAKNSAKDKYKTILQVIRGQLDQTSLMNTTACSKLPI GK032_Glam -------------------YK--------------------------------------- smi35A_Dmel ------TANTTNLGYDDD----------NGNYK------------------IIEHDHIAF Dyrk3_Dmel --------GPNNSEYDNE----------QGAYI------------------HVPHDHVAY DYRK4_Mmus ------E-KFSKTSFDDE----------HGSYM------------------KVLHDHIAY DYRK3_Mmus ------G-GPNNGGYDDA----------DGAYI------------------HVPRDHLAY DYRK2_Mmus ------G-GPNNGGYDDD----------QGSYV------------------QVPHDHVAY mbk-2_Cele ------G-GANNGGYDDE----------NGSYQ------------------LVVHDHIAY C36B7.2_Cele -------NA-IEKDFFEM----------GSIYK------------------MKKDEHIGY C36B7.1_Cele ----------ELGIFTLP----------NGSYC------------------FKEGDHISY DYRK4_Hsap ------E-KFSKTSFDDE----------HGFYL------------------KVLHDHIAY DYRK3_Hsap ------G-GPNNGGYDDA----------DGAYI------------------HVPRDHLAY DYRK2_Hsap ------G-GPNNGGYDDD----------QGSYV------------------QVPHDHVAY Dyrk2_Ddis ------SQLP-NNGYDND----------IGEYK------------------VVERDHIAY 5306_Tthe --------AQENGNNDDT----------KGDYQ------------------YNVNDHIAY 5356_Tthe ------QANSYNFGYDDENLQKYYLIIKRGDYL------------------YTLNDHIAY 5655_Tthe --------SQFNNGFDDS----------RGEYQ------------------LNLLDHIAY DYRK2_Spur ------G-GASNCGYDDD----------QGSYI------------------HVQHDHVAY DYRK4_Spur ------G-ASQNNGYDDE----------NGSYI------------------KVIHDHLAY CC1G_13957_Ccin ------DITTNNYSYDDE----------RGDYQ------------------VVLGDHLAY AqueK112_Aque ------G-GSQNCGYDDE----------NGSYI------------------KVLHDHISY AqueK113_Aque ------G-APQNSGYDDD----------AGTYL------------------IVAHDHVSY DYRK2_b_Smoe ------GQGRYNYGFDTE----------KGDYN------------------AIMQDHIAY DYRK2_a_Smoe ------GQGRYNYGFDTE----------KGDYN------------------AIMQDHIAY GK034_Glam ------NGA-INHGYDDS----------RGDYI------------------GVINDHIMY GK033_Glam YYNPLHTGAIEVTTPDD------------ADVP------------------FIEGETILN GK032_Glam ------G-ETRNSKLLD----------LVGFYNIPLYYGLYSEFKGLHEMRFKKGAVLAG . : smi35A_Dmel RYEILEVIGK-GSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDAD Dyrk3_Dmel RYEMLKIIGK-GSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKY DYRK4_Mmus RYEVLEMIGK-GSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKD DYRK3_Mmus RYEVLKIIGK-GSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT DYRK2_Mmus RYEVLKVIGK-GSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKD mbk-2_Cele RYEVLKVIGK-GSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSD C36B7.2_Cele RYTIDKVIGQ-GCYGVVGEATDGKTKQKVAIRMVS---KLAPRIYRETEMIMYISSIDPD C36B7.1_Cele RYSIDEVLSS-GYYAQVFRCTDKKTDKKVCIKLKN---RNLSTTYEETIILLRIHQLNRQ DYRK4_Hsap RYEVLETIGK-GSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKD DYRK3_Hsap RYEVLKIIGK-GSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT DYRK2_Hsap RYEVLKVIGK-GSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKD Dyrk2_Ddis RFEIVSILGQ-GSFCQVVKGYDYKTGEMVALKILRNQKRFHNQALTEIKILEYLKTNDPN 5306_Tthe RYEIKEFLGK-GSFGQVLKVFDHKRKEYAALKVIRNKQKFHEQALIELNILHYIKEKDYD 5356_Tthe RYELIEALGK-GSFGQVIKVFDHKRKEYSALKIIRNKKNFYNQAIVELNILKYIKDNDPQ 5655_Tthe RYELLECLGK-GSFGSVVKVFDHKRKEFLALKVIRNKKKFHNQALIELNILSYIKEQDKD DYRK2_Spur RYEVLKILGK-GSFGQVVKVYDHKTNQHIAVKMVRNEKRFHRQAQEEIRILEHLRKQDKD DYRK4_Spur RYEILEVIGK-GSFGQVVKAFDHKLGEMIAIKIIRNKKRFHHQALIEVKILDALRRKDRD CC1G_13957_Ccin RYEVVDTLGK-GSFGQVLNCRDHCTGESVAVKIIRNKKRFHHQALVEIKILDNLRKWDAD AqueK112_Aque RYEIREIIGK-GSFGQVVKVFDHKTNQHIALKIIRNKKRFHHQALVEVKILDSLRKRDRD AqueK113_Aque RYEVLKVLGK-GSFGQVLKAYDHKMQTHIALKVVRNEKRFHRQAQEEVKILEHLRRQDKD DYRK2_b_Smoe RYEILGKLGR-GSFGQVLKCTDHKYKVPRAIKIIRNKKQFTQQAFIEINLLEFLRNKAAE DYRK2_a_Smoe RYEILGKLGR-GSFGQVLKCTDHKYKVPRAIKIIRNKKQFTQQAFIEINLLEFLRNKAAE GK034_Glam RYELVSKLGS-GSFGKVYKALDHKEQQFVALKIIKNRKRFQRQGLVEVKILELLRDNDPN GK033_Glam RYKLLKMVGS-ATFSNVFSCLDLKDNVTYCLKIIKQEKEFFDQAIDEVHLLELLKDIDPN GK032_Glam RYEIYKTIFEDSAFSVTLKARDLKEGKDVCLKVVNNEKDTLDQCLNEIRLLTYINKHDPT *: : : . : . * .::: * :: : smi35A_Dmel G--SHNVIHMLDYTYFRKHLCITFELMSLNLYELIKK-N-----------NYNGFSMSLI Dyrk3_Dmel N--TMNIIHMFDYFTFRNHTCITFELLSINLYELIKK-N-----------GFKGFSLQLV DYRK4_Mmus N--NHNVVHMKDFFYFRNHLCITFELLGINLYELMKN-N-----------SFHGFNLSIV DYRK3_Mmus G--SMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK-N-----------KFQGFSVQLV DYRK2_Mmus N--TMNVIHMLENFTFRNHICMTFELLSMNLYELIKK-N-----------KFQGFSLPLV mbk-2_Cele G--THNIIHMLDYFNFRNHKCITFELLSINLYELIKR-N-----------KFQGFSLMLV C36B7.2_Cele H--TFDCVRMLDYNVFRGFHYVVTDLFDTSVKKYIKE-H-----------HPNGIALENV C36B7.1_Cele N--NSNCVRMLDYDHFRGHHFIVLENYQTDLASYLCGRS-----------KLTP---REY DYRK4_Hsap N--TYNVVHMKDFFYFRNHFCITFELLGINLYELMKN-N-----------NFQGFSLSIV DYRK3_Hsap G--SMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK-N-----------KFQGFSVQLV DYRK2_Hsap N--TMNVIHMLENFTFRNHICMTFELLSMNLYELIKK-N-----------KFQGFSLPLV Dyrk2_Ddis S--TASIVHLNNYFYFRNHLILTFELLSMNLYDFLKV-N-----------HFQGYNLNLV 5306_Tthe N--QTNIVKIRDFVIFRNHVCLVFELLSINLYDLLRN-N-----------KFQGLSLELI 5356_Tthe N--QTNIVKIKDFVIFRSHVGLL------------------------------------- 5655_Tthe E--ATNIVRIKDFVIFRKHV---------------------------------------- DYRK2_Spur N--NMNLIHMFESFSFRNHICITFELLSMNLYELIKK-N-----------KFQGFSLQLV DYRK4_Spur N--SHNVVHMREYFYYRNHLCITFELLGMNLYELIKK-N-----------NFQGFSVALI CC1G_13957_Ccin E--KHHVLKMTEHFYFRNHLCIATELLSINLYELIKA-N-----------GFVGFTTALI AqueK112_Aque N--QYNIIHMFDYFYFRNHLCITFELMGMNLYELIKK-N-----------NFQGFSISLI AqueK113_Aque N--AHNIIHMIDHFTFRNHVCITFELLSMNLYELIKK-N-----------KFQGFSLALV DYRK2_b_Smoe EGVDYNIVTIYESFEFRGHLCLSFAVHDISLFDMLKK-N-----------HFEGFNLSLV DYRK2_a_Smoe EGVDYNIVTIYESFEFRGHLCLSFAVHDISLFDMLKK-N-----------HFEGFNLSLV GK034_Glam G--DQCCVKVLSSFYFRSHLCIAFELLSINLYELLTK-K-----------DLKGLSLSLV GK033_Glam N--NINIIKIHDYFYFREHLLLKFTLLGEDLYTHFNR-REK-------KGQPNDYTIPVI GK032_Glam G--K-HFVRMTDYFYYGHRLIIIFELLTSNLFSYYSA-REAALPRTLLNPLATIFTMPRL : : . : smi35A_Dmel RRFCNSIVKCLRLLYKENIIHCDLKPENILLKQR------GSSSIKVIDFGSSCYVDRK- Dyrk3_Dmel RKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQ------GRSGIKVIDFGSSCFENQR- DYRK4_Mmus RRFTFSILKCLHMLYVEKIIHCDLKPENIVLYQR------GQVTVKVIDFGSSCYEHQK- DYRK3_Mmus RKFAQSILQSLDALHKNKIIHCDLKPENILLKHH------GRSATKVIDFGSSCFEYQK- DYRK2_Mmus RKFAHSILQCLDALHKNRIIHCDLKPENILLKQQ------GRSSIKVIDFGSSCYEHQR- mbk-2_Cele RKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQ------GRSGIKVIDFGSSCFDDQR- C36B7.2_Cele AAMGRKILKGLVFLHEHNIVHGDLKPENIMLNLA------NPNDVKLGDFGLSRFAKPYH C36B7.1_Cele IPMIKSIVHGLKFLHQNKIIHGDLKPANVLLNEW------NRNNLKLTDFGLSTFVNQGP DYRK4_Hsap RRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQK------GQASVKVIDFGSSCYEHQK- DYRK3_Hsap RKFAQSILQSLDALHKNKIIHCDLKPENILLKHH------GRSSTKVIDFGSSCFEYQK- DYRK2_Hsap RKFAHSILQCLDALHKNRIIHCDLKPENILLKQQ------GRSGIKVIDFGSSCYEHQR- Dyrk2_Ddis RRFGAQILTSLRFLSKRNIIHADLKPENILLKSP------TKSGIKLIDFGSSCFENEQ- 5306_Tthe RRFAIQLLNAISFLKENRIIHCDLKPENVLLKQP------NKSGIKIADFGSSCFDDQV- 5356_Tthe ------------FLTKANIIHCDLKPENILLKQE------NKSGIKIVDFGSSCFENQR- 5655_Tthe ------ILNSINFLRKNRIIHCDLKPENILLKQA------NKSGVKLIDFGSSCFENER- DYRK2_Spur RKFAHSLLQCLEGLHRNKIIHCDLKPENILLKQQ------GRSGIKVIDFGSSCYEHQR- DYRK4_Spur RRFAFSLLQCLRMLHKERIIHCDLKPENILLRQK------GQSTIKVIDFGSSCYEHQR- CC1G_13957_Ccin RRFTTQMLMSLSLMRHHRIVHCDLKPENVLLRHP------AKSAIKVIDFGSSCLEHEK- AqueK112_Aque RRFAYSMLQCLKILYRERIIHCDLKPENILLRLR------GQSSIKVIDFGSSCYEHQR- AqueK113_Aque RKFAHSILQCLDSLYRNRIIHCDLKPENILLKQP------GRSGIKVIDFGSSCYEYQR- DYRK2_b_Smoe KCFARQVLVSLQFLHRARIIHGDLKPENILLQQP------ASPKIKLIDFGSSCFEHER- DYRK2_a_Smoe KCFARQVLVSLQFLHRARIIHGDLKPENILLQQP------ASPKIKLIDFGSSCFEHER- GK034_Glam RKFSLQLLIAFAYARKLRIIHADVKPENILLREP------DKSSIKVIDWGSGAMVSET- GK033_Glam RDMARQVLKALDYIHRLGITHLDLKPENLLHGDKNFIGGVNEPSVTLVDFGSSSFIFDK- GK032_Glam QHIARQILESLDFLHRLNILHLDLKHENLLLVNED----DDSFDIRLVDIGSSAFLYDE- : * *:* *:: : * * . smi35A_Dmel IYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVE--------Q Dyrk3_Dmel IYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESD--------Q DYRK4_Mmus VYTYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYTGYPLFPGENEVE--------Q DYRK3_Mmus LYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD--------Q DYRK2_Mmus VYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGD--------Q mbk-2_Cele IYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDEND--------Q C36B7.2_Cele DHVQCQSMFYRAPEAFVRGRYNGATDMWSFGCTVAEMVSGKIFLAGDNCDD--------Q C36B7.1_Cele FFRDYQTLYYKAPEVFCQGKVSVEIDIWSLGCVAAEIVRGTPLFVGDNYFD--------Q DYRK4_Hsap VYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVE--------Q DYRK3_Hsap LYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD--------Q DYRK2_Hsap VYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGD--------Q Dyrk2_Ddis IFTYIQSRFYRSPEVILGTKYDKSIDIWSLGCILVEIFTGVPLFPGSDEPE--------Q 5306_Tthe MYTYIQSRYYRSPEVILGIPYGTEIDMWSFGCIIAELFLGYPIFPGEDENE--------Q 5356_Tthe VYTYIQSRFYRAPEIILGLPYGKAIDMWSFGCIMAELYIGYPLFPGENEAE--------Q 5655_Tthe LYTYIQSRYYRAPEVILGLPYDTSIDMWSFGCIMAELFIGYPIFPGEDEQE--------Q DYRK2_Spur IYTYIQSRFYRAPEVILGGKYGMPIDMWSLGCILAELLTGYPLLPGEDEGD--------Q DYRK4_Spur VYTYIQSRFYRSPEVILGLPYGLPIDMWSFGCILAELYTGYPLFPGENEVE--------Q CC1G_13957_Ccin ----------------------------------TELYTGFPIFPGENEQE--------Q AqueK112_Aque VYTYIQSRFYRSPEVILGLPYSMAIDMWSLGCILAELYTGYPLFPGENEVE--------Q AqueK113_Aque VYTYIQSRFYRAPEVILGGKYGMSIDMWSFGCILAELLTGYPLFPGEDEGD--------Q DYRK2_b_Smoe IYTYIQSRFYRAPEVILGLPYDMMIDVWSFACILAELFTGYPLFPGEDEVE--------Q DYRK2_a_Smoe IYTYIQSRFYRAPEVILGLPYDMMIDVWSFACILAELFTGYPLFPGEDEVE--------Q GK034_Glam IYSYIQSRFYRAPEVILGLPYGQEIDIWSIGCVLCELYTGLPIFPGDDERD--------Q GK033_Glam MHSYIQSRSYRAPEVILATPYDSRADIWSFGCVVCELLTGRVLFPNYSVAT--------I GK032_Glam CSTYVQSRSYRCPEVILGLPYDGRADVWSLGPILTELITGKVMFPIPQKADEDHKPYASM *: * :: . smi35A_Dmel LACIMEVLGLPPKVLISVARRRRLFFDS-RDAPRCITN---------------------- Dyrk3_Dmel LACIIEVLGMPNKNILASSKRSKSFFSP-KGYPRYCTV---RT----------------- DYRK4_Mmus LACIMEVLGLPPAHFTQTASRRQVFFDS-KGLPKNINN---------------------- DYRK3_Mmus LACMIELLGMPPQKLLEQSKRAKYFINS-KGLPRYCSV---ST----------------- DYRK2_Mmus LACMIELLGMPSQKLLDASKRAKNFVSS-KGYPRYCTV---TT----------------- mbk-2_Cele LALIIELLGMPPPKSLETAKRARTFITS-KGYPRYCTA---TS----------------- C36B7.2_Cele FYLMQEVINIPPPVFFDTFYTNYYFFSTLKEAPKHIVI---TDHG--------------- C36B7.1_Cele FALIQEFFGKPSRKLFNTWGGIHQFYTE-YFFPRHCFEWLNPFNG--------------- DYRK4_Hsap LACIMEVLGLPPAGFIQTASRRQTFFDS-KGFPKNITN---------------------- DYRK3_Hsap LACMMELLGMPPPKLLEQSKRAKYFINS-KGIPRYCSV---TT----------------- DYRK2_Hsap LACMIELLGMPSQKLLDASKRAKNFVSS-KGYPRYCTV---TT----------------- Dyrk2_Ddis LACIMEVLGAPPKSVIDNSTRKDIFFED-DGTPKPVKN---STTG--------------- 5306_Tthe MGYIMELLGAPDSEFLKKCSRKKYFFDQ-NDQPLQIPN---------------------- 5356_Tthe FQMFMEILGIPEEEFVENCPRRNVFFEN-NKTPKVVKN---------------------- 5655_Tthe IGYIWEIIGAPSKDFLQNCTRRKYFFNE-DYTPKLIPN---------------------- DYRK2_Spur LACMIEVMGMPSQNLIDTSKRSKNFINS-KGQPRYCTV---TT----------------- DYRK4_Spur LACIMEIFGLPPPHIIEEAQRRRLFFED-SSAPDVSKK---------------------- CC1G_13957_Ccin LSCIMEVLGVPDKEYINRSSRKKLFFDT-NGAPRPVVN---S-KG--------------- AqueK112_Aque LACIIEIFGLPDPALLAEAQRKKLFFDS-RGNPRCVTN---------------------- AqueK113_Aque LACMMEVLGLPSQKMIESTKRGRTFFSS-KGHPRYTTV---NI----------------- DYRK2_b_Smoe LAYMMEVLGTPPLSLISQAKRKKMFFDS-DNKPRIVPN---------------------- DYRK2_a_Smoe LAYMMEVLGTPPLSLISQAKRKKMFFDS-DNKPRIVPN---------------------- GK034_Glam LGKICELLGMPPNDMIFKSPRKNDFFVN-IGTGMGVAG---VSEGGNPIFSGNLQQLSSV GK033_Glam LSRICSLIGPIPRDMIMSGRMGQRVLTF-GLVPYEH------------------------ GK032_Glam LAKLIGIIGPIPRDMILAGRESHKLFTK-DLFL-F------------------------- : : .:. . smi35A_Dmel ---------------------TKGRKR-S-----------PGSKS------L-------- Dyrk3_Dmel --------MSDGMVVLIGGQSRRGKQRGP-----------PCSKS------L-------- DYRK4_Mmus ---------------------NRGGKR-Y-----------PDSKD------L-------- DYRK3_Mmus --------QTDGRVVLLGGRSRRGKKRGP-----------PGSKD------W-------- DYRK2_Mmus --------LSDGSVVLNGGRSRRGKLRGP-----------PESRE------W-------- mbk-2_Cele --------MPDGSVVLAGARSKRGKMRGP-----------PASRS------W-------- C36B7.2_Cele ----------P---IVSFIYTKAADHRKI-----------PGATP------I-------- C36B7.1_Cele ----------DRTMEIEPHYKLAHPSRKP-----------PLTSS------L-------- DYRK4_Hsap ---------------------NRGKKR-Y-----------PDSKD------L-------- DYRK3_Hsap --------QADGRVVLVGGRSRRGKKRGP-----------PGSKD------W-------- DYRK2_Hsap --------LSDGSVVLNGGRSRRGKLRGP-----------PESRE------W-------- Dyrk2_Ddis ------------------------ELY-T-----------IGTKS------F-------- 5306_Tthe ---------------------SRGKIR-M-----------PNSKN------W-------- 5356_Tthe ---------------------SRGKIR-T-----------PATKH------I-------- 5655_Tthe ---------------------SKGKIR-V-----------PNSKI------L-------- DYRK2_Spur --------LPDGTTVLNGGRSRRGKVRGP-----------PGSKD------L-------- DYRK4_Spur ----------------------NGLRI-S-----------REKSN------L-------- CC1G_13957_Ccin ------------------------RRR-R-----------PGSKT------L-------- AqueK112_Aque ---------------------SKGKKR-R-----------PGSKD------L-------- AqueK113_Aque --------NPDGTASYTGGRSRRGKFRGP-----------PGTKD------M-------- DYRK2_b_Smoe ---------------------SSGTRH-F-----------PSTKD------L-------- DYRK2_a_Smoe ---------------------SSGTRH-F-----------PSTKD------L-------- GK034_Glam NEYLQATGRGAGGSEVPGIRLR--TTH-K-----------VNSKT------L-------- GK033_Glam ------------------DEKNRQHFYFT-----------PQQGL------LEYWLFGER GK032_Glam ----------ETREAILGNRDKAEGLRHAEIKGEDYVYVLPKKTTIKAMLGW-------- smi35A_Dmel AHIL-HCQDRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQPSASSRHRS--CRMSSS-SS Dyrk3_Dmel SKALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRRLPRPPSS--SS--G--CG DYRK4_Mmus TMVVK-TYDSSFLDFLRRCLVWEPSLRMTPEQALKHAWIHEPRKFKPRPKPQILRKP-GA DYRK3_Mmus ATALKGCGDYLFIEFLKRCLQWDPSARLTPAQALRHPWISKSTPKPLTM--DKVP---GK DYRK2_Mmus GNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTG--EKTA---VK mbk-2_Cele STALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLRRRLPNPPRD--GLE-S--MG C36B7.2_Cele GSFFTKTEQKPFNNFILKVFKWMPASRITAKQALDHPFFYSLSACFNQQ----------- C36B7.1_Cele VSKLPGGNQKFLARFLMRCFEWDPTERIKSSFILNHPFFHESI----------------- DYRK4_Hsap TMVLK-TYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKS-NS DYRK3_Hsap GTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTT-IDKVS---GK DYRK2_Hsap GNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTG--EKTS---VK Dyrk2_Ddis KDSIR-SGDEDFDNFILDCLKWEPSQRITAEQGLKHDWIIKVIAPT-------------- 5306_Tthe KSVI-GCTDDNFIDFIKKCLVWEPSQRLTPRDALLHPWILDGLPEDIRV--QHIKF--LK 5356_Tthe NYYL-RCPDENFIDFVSKCFTWKNHERMSPAEALVHDWILEGLPEEIRA--QHLQQ--MQ 5655_Tthe KAVL-QTESEDFTDFLTKCFVWEPQKRLKPSDALMHPWILEGLPPEIRI--QHIKY--IQ DYRK2_Spur VKALKGCDDPLFLDFLKRCLEWDPSSRMTPSQALRHSWLRRRLPKPPAD--GHAN---TT DYRK4_Spur ----N-AK----SDFVMPPIHLGINADLTAEKPVN-----K---VKPLLA---EDKAPSI CC1G_13957_Ccin AQVLR-CNDEEFIDFIAKCLVWDPERRMKPQAAMRHPFVTAGKRKAQQQAAARATP--SS AqueK112_Aque SSAIK-TSDLLFLDFIRRCLVWSASERMKPEEALQHAWIQEGFHSRPRATPRALHISPSS AqueK113_Aque SRALKGCDDPQFLDFLRHCLEWDPAIRMTPPQALRHPWLRRRLPRAPII--SDGQS--LS DYRK2_b_Smoe RMVV-GCSDKSFVNFLSCCLKWDKEQRMTPQQLLKHEWITQVLLFPRES-FGLIGF---- DYRK2_a_Smoe RMVV-GCSDKSFVNFLSCCLKWDKEQRMTPQQLLKHEWITQVLLFPRES-FGLIGF---- GK034_Glam SGVLN-APD-DFISFISLFLQWDPQRRCTPEVAMSHPWIQEGIRQINERN---ARP--SS GK033_Glam CANL-TDEEVLFSDFCRQALIVDPIKRPTAAMLLEHPFIKGA------------------ GK032_Glam DSHPE-YCDDLFLDFIETIMRIDPRKRPTAAEALEHPWLKH------------------- * : .. smi35A_Dmel S-SG--LNSVSQKSSCYSFSEISPGTNGPVVASITST--TAVH----------------- Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ---S--IS---------------------------SE--ISTEKAEEQQASKGKK----- DYRK3_Mmus R-VV-------------------------------------------------------- DYRK2_Mmus R-VT-------------------------------------------------------- mbk-2_Cele G-LA-------------------------------------------------------- C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ---F--FP---------------------------SE--TRKDKVQGCHHS-SRK----- DYRK3_Hsap R-VV-------------------------------------------------------- DYRK2_Hsap R-IT-------------------------------------------------------- Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe D-KS--FET--A-----------------------SE--KEFHKQSCLQ-AQ-------- 5356_Tthe Q-TSPEIDM-TK-----------------------SQ---SSNKANTIEDQP-------- 5655_Tthe S-QV-EIDRLTQ-----------------------EQ--QQYDKQ--------------- DYRK2_Spur S-AK-------------------------------------------------------- DYRK4_Spur E-V--------------------------------------------------------- CC1G_13957_Ccin S-S---LS---------------------------SHRSKHIT----------------- AqueK112_Aque S-AG--TP---------------------------SS--SSHYHSQTLPSHQQKPNGRHG AqueK113_Aque QGIP--PHL--P-----------------------SA--AAVHL---------------- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam T-A---VR---------------------------AVDA--------------------- GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel ------------------NA-A----IATTTK-----------S---------------- Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus DE--ATKETT---DKLKDEA-E----KHLENS--G--------KQQSSVEHTADT----- DYRK3_Mmus ------------------NP-T----NAFQGL--G--------S---------------- DYRK2_Mmus ------------------ES-T----GAITSI-----------S---------------- mbk-2_Cele ------------------------------------------------------------ C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap DE--ITKETT---EKTKDSP-T----KHVQHS--G--------DQQDCLQHGADT----- DYRK3_Hsap ------------------NP-A----SAFQGL--G--------S---------------- DYRK2_Hsap ------------------ES-T----GAITSI-----------S---------------- Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe ------------------YN-A----DAQSAA-MA--------L-----------AL--- 5356_Tthe ------------------QN-N----ENTSGVGQG--------R----------NSFKKA 5655_Tthe ------------------NN-N----SMTSSM-PS--------T-----------NLPES DYRK2_Spur ------------------NK-R----HGSSAV-----------S---------------- DYRK4_Spur -------------IE-VEDS-E----KFLENL--E--------L---------------- CC1G_13957_Ccin ------------------ETPKKSMIGAPTPL--TARTPRSSHT---------------- AqueK112_Aque SSQPPSDI-SPGSVSYTDSS-R----RRLHPV--G--------S---------------- AqueK113_Aque ------------------SS-S----GAATNK-----------Q---------------- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel ------------------------------------------------------------ Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus ------------------------------------------------------------ DYRK3_Mmus ------------------------------------------------------------ DYRK2_Mmus ------------------------------------------------------------ mbk-2_Cele ------------------------------------------------------------ C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------------------------------------------ DYRK3_Hsap ------------------------------------------------------------ DYRK2_Hsap ------------------------------------------------------------ Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe ------------------------------------------------------------ 5356_Tthe EMNNSSSFGPSVVSVNTGLQERNKNIINSQSHQIQDV----------KINPQSQASNPSS 5655_Tthe KNTETSTIQSSQIGIKENM-----------------LKSDLKEFNQFGIPQNLNVQSSKN DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur ------------------------------------------------------------ CC1G_13957_Ccin ------------------------------------------------------------ AqueK112_Aque ------------------------------------------------------------ AqueK113_Aque ------------------------------------------------------------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel -----------------------------------------------------RQQPPS- Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus -----------------------------------------------------IQLPHL- DYRK3_Mmus ------------------------------------------------------KLPPV- DYRK2_Mmus ------------------------------------------------------KLPPP- mbk-2_Cele ------------------------------------------------------------ C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap -----------------------------------------------------VQLPQL- DYRK3_Hsap ------------------------------------------------------KLPPV- DYRK2_Hsap ------------------------------------------------------KLPPP- Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe --------------------------------------------------------QK-- 5356_Tthe SSCQNAINKYGQKQNNAKNYVFKNQNPLNSVTNNQPLSQSKIEQAENPSSNNLSQIPLNQ 5655_Tthe ASEKN---------------------------------------------KNNMYIPSP- DYRK2_Spur ------------------------------------------------------KLPPT- DYRK4_Spur ------------------------------------------------------DEKNV- CC1G_13957_Ccin -----------------------------------------------------SGVPNT- AqueK112_Aque -----------------------------------------------------DSQPKV- AqueK113_Aque -----------------------------------------------------RQLPEA- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ----------------------------------------------------------R- GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel --QSHGHAQSNGHLPDIKLSASDKYNSMQKVAVRSKITSSVSDLESVQQYSLHRIYGGVG Dyrk3_Dmel ------------------------------------------------------------ DYRK4_Mmus --TE-------------------------------------------------------- DYRK3_Mmus --VG-------------------------------------------------------- DYRK2_Mmus --SS-------------------------------------------------------- mbk-2_Cele ------------------------------------------------------------ C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap --VD-------------------------------------------------------- DYRK3_Hsap --VG-------------------------------------------------------- DYRK2_Hsap --SS-------------------------------------------------------- Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe -IYK-------------------------------------------------------- 5356_Tthe GISL-------------------------------------------------------- 5655_Tthe -VNS-------------------------------------------------------- DYRK2_Spur ---G-------------------------------------------------------- DYRK4_Spur --ID-------------------------------------------------------- CC1G_13957_Ccin --PG-------------------------------------------------------- AqueK112_Aque --LE-------------------------------------------------------- AqueK113_Aque PISN-------------------------------------------------------- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam --PD-------------------------------------------------------- GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel SGSTHHVSSAATRKHLPGTGSGI--------VGAMSSKYGSSTLAHNHHNVTHHNASTAT Dyrk3_Dmel ---------------------------------GV------------------------- DYRK4_Mmus ----------------------A--------SGKSETV---------------------- DYRK3_Mmus ----------------------I--------ASKLKAN---------------------- DYRK2_Mmus ----------------------S--------ASKLRTN---------------------- mbk-2_Cele --------------------------------DHEK------------------------ C36B7.2_Cele ------------------------------------------------------------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ----------------------A--------PKKSEAA---------------------- DYRK3_Hsap ----------------------I--------ANKLKAN---------------------- DYRK2_Hsap ----------------------S--------ASKLRTN---------------------- Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe ----------------------Y--------NNKKRIL---------------------- 5356_Tthe ----------------------Q--------NNKKKTD---------------------- 5655_Tthe ----------------------S--------ANQQKIQ---------------------- DYRK2_Spur ----------------------A--------AGKD------------------------- DYRK4_Spur ----------------------S--------QE--------------------------- CC1G_13957_Ccin ----------------------S--------SSHT-SS---------------------- AqueK112_Aque ----------------------P--------ATRRN-G---------------------Y AqueK113_Aque ----------------------NATTAAPMTNGKLSNS---------------------- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ----------------------S--------RRV-------------------------- GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel ------------------------IATTTHHHHHHGGQQQQQSSSGASTMAMSH------ Dyrk3_Dmel --------------------------------------------------S-GL------ DYRK4_Mmus ------------------------AGSE---------------------MS-AE------ DYRK3_Mmus ------------------------L----------------------------M------ DYRK2_Mmus ------------------------L----------------------AQ----M------ mbk-2_Cele -----------------------------------------------KT-E-TL------ C36B7.2_Cele -----------------------------------------------------M------ C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap ------------------------VGAEV------------------SMTS-PG------ DYRK3_Hsap ------------------------L----------------------------M------ DYRK2_Hsap ------------------------L----------------------AQ----M------ Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe ------------------------E----------------------K-----K------ 5356_Tthe ------------------------M----------------------I-----HLSDFNP 5655_Tthe ------------------------I----------------------K-----A------ DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur --------------------------------------------------K--------- CC1G_13957_Ccin ------------------------FGS---------------------STR-SY------ AqueK112_Aque NKRNSLVIDSTGSVMRGGGAFPIATAGE---------------------TE--------- AqueK113_Aque ------------------------H----------------------SS-Q-TL------ DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel -------------S-------------------------------------QS------- Dyrk3_Dmel -------------C---------------------------------------------- DYRK4_Mmus -------------Q-------------------------------------QS------- DYRK3_Mmus -------------S-------------------------------------ET------- DYRK2_Mmus -------------T-------------------------------------DA------- mbk-2_Cele -------------P---------------------------------------------- C36B7.2_Cele -------------S-------------------------------------LA------- C36B7.1_Cele ------------------------------------------------------------ DYRK4_Hsap -------------Q-------------------------------------SK------- DYRK3_Hsap -------------S-------------------------------------ET------- DYRK2_Hsap -------------T-------------------------------------DA------- Dyrk2_Ddis ------------------------------------------------------------ 5306_Tthe -------------S-------------------------------------TT------- 5356_Tthe YESDQFSNTFSAATTTNAKKTQQQFGFVQNNTPQHQNLNGIKANNFLQQGNSQNQSIYPN 5655_Tthe -------------E-------------------------------------STKHSYDPN DYRK2_Spur ------------------------------------------------------------ DYRK4_Spur -------------Y-------------------------------------AK------- CC1G_13957_Ccin -------------R-------------------------------------TS------- AqueK112_Aque -------------H-------------------------------------ND------- AqueK113_Aque -------------L-------------------------------------QS------- DYRK2_b_Smoe ------------------------------------------------------------ DYRK2_a_Smoe ------------------------------------------------------------ GK034_Glam ------------------------------------------------------------ GK033_Glam ------------------------------------------------------------ GK032_Glam ------------------------------------------------------------ smi35A_Dmel -------------------------T-----GDVSDRAI-------F-GRA Dyrk3_Dmel -------------------------------SSRNESPV-----TGK-LDL DYRK4_Mmus -------------------------T-----SSPKSTNI------LP-PIV DYRK3_Mmus -------------------------S-----GSIPLCSV-----LPK-LIS DYRK2_Mmus -------------------------N-----GNIQQRTV-----LPK-LVS mbk-2_Cele -------------------------------NIDSNANI-----LMR-KKF C36B7.2_Cele -------------------------D-----G--PLFA-----PKVK-RAA C36B7.1_Cele ------------------------------------------------NIQ DYRK4_Hsap -------------------------N-----FSLKNTNV------LP-PIV DYRK3_Hsap -------------------------N-----GSIPLCSV-----LPK-LIS DYRK2_Hsap -------------------------N-----GNIQQRTV-----LPK-LVS Dyrk2_Ddis --------------------------------------------APS-TPS 5306_Tthe -------------------------Q-----GTVSEET------RNS-VVN 5356_Tthe QIKIRRPDSSKKNKIEQN-FVANEDL-----QKNSNLQ------IQS-GEN 5655_Tthe ----------QGNNIEKQLYFISQKR-----KQHQNNQ------QNI-KID DYRK2_Spur -------------------------R-----QDVSQRTV-----LPK-IVT DYRK4_Spur -------------------------K-----EQKQSGQF------LP-PIV CC1G_13957_Ccin -------------------------QGHSLSSSVHSSRVMNGYSSTA-STK AqueK112_Aque -------------------------P-----SCRSPSTS------SP-PPQ AqueK113_Aque -------------------------D-----QLSSNRTV-----LPKIIDR DYRK2_b_Smoe -----------------------------------YRS------SLS-TRS DYRK2_a_Smoe -----------------------------------YRS------SLS-TRS GK034_Glam -------------------------------ASASQRPL---LPALS-PKK GK033_Glam ----------------------------------------------D-LLL GK032_Glam -------------------------------------------------VY