CLUSTAL W (1.83) multiple sequence alignment ERK4_Mmus MAEKG---------------------DCIASVYGYDLGGRFIDFQPLGFGVNGLVLSATD ERK3_Mmus MAEKF---------------------ESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVD Erk4_Hsap MAEKG---------------------DCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVD Erk3_Hsap MAEKF---------------------ESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVD ERK3_Spur MALLFVLFLCTGRLWLNSMARLDSPTEGLYLPH--GIGSRFCDLRPLGYGSSGTVFSAVD ** : : : .:*.*: *::*** * .* *:**.* ERK4_Mmus SRACRKVAVKKIVLSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGSDL--Q---GE ERK3_Mmus NDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQL--TDDVGS Erk4_Hsap SRACRKVAVKKIALSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGTDL--Q---GE Erk3_Hsap NDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQL--TDDVGS ERK3_Spur SECDKSVAIKRVSLTDKKSCKSALREIRILRKLQHENIVKIYDVIFDGNSDNSEDEDISI . . : **:*:: *:* :* * *****:*:*:*:*:****::::: .:: . ERK4_Mmus LFKFSVAYIVQEYMETDLACLLEQGTLTEDHAKLFMYQLLRGLKYIHSANVLHRDLKPAN ERK3_Mmus LTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPAN Erk4_Hsap LFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPAN Erk3_Hsap LTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPAN ERK3_Spur PSELRTLCIVQELVDADLRVVMEQQRISNEHVRLFAYQLLRGLKYLHSANVLHRDLKPEN :: **** :::** ::** : ::*.:** *********:************ * ERK4_Mmus IFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWA ERK3_Mmus LFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWA Erk4_Hsap IFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWA Erk3_Hsap LFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWA ERK3_Spur VLINQEDLVLKIGDFGMARIVDPDYSHKGYLTQNVSTQWYRSPELVLQPTDYTKAIDLWS ::*. ***********:***:* .*****:*::.: *:*****.*:*.*.:******:*: ERK4_Mmus AGCILAEMLTGKMLFAGAHELEQMQLILDTIPVVREEDKEELLRVMPSFV-SS-TWEVKR ERK3_Mmus AGCIFAEMLTGKTLFAGAHELEQMQLILDSIPVVHEEDRQELLSVIPVYI-RNDMTEPHR Erk4_Hsap AGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRVMPSFV-SS-TWEVKR Erk3_Hsap AGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYI-RNDMTEPHK ERK3_Spur AGCILAEMVTGKPLFPGDHDLELMMLVLDSVQ-LNDRDLNEILCTLPSKLLKNYNGYPRH ****:***:**: **.* *:** * *:*::: :.:.* :*:* .:* : . :: ERK4_Mmus PLRKLLPDVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPFRIED ERK3_Mmus PLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPTDEPISSHPFHIED Erk4_Hsap PLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPFRIED Erk3_Hsap PLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIED ERK3_Spur PLKEVLCNLDCHALDLLLAMLTFDPSERITAEEALRSPYFKVYSCIRDEAKATHPFHIEN ** ::* :. .*:*:* :***.* :*:*** .* **:. ** **. : ***:**: ERK4_Mmus EIDDIVLMAASQSQL--------------------------------------------- ERK3_Mmus EVDDILLMDETHSHI--------------------------------------------- Erk4_Hsap EIDDIVLMAANQSQL--------------------------------------------- Erk3_Hsap EVDDILLMDETHSHI--------------------------------------------- ERK3_Spur EIDDLPPIVIKKIILEECLERTDVDVSFGGRTANVCDESEDNSSSSRDLVQSSTEGSLGS *:**: : .: : ERK4_Mmus -----------------------------------------------SNWD----RYPVS ERK3_Mmus -----------------------------------------------YNWE----RYHDC Erk4_Hsap -----------------------------------------------SNWDTCSSRYPVS Erk3_Hsap -----------------------------------------------YNWE----RYHDC ERK3_Spur FSDEEAKEACIDNAFLNRMVSVGNNRSDDSEKNETEESEKSDDEEKEAKWE----DFKEM :*: : ERK4_Mmus LS---SDLEWRPDRCQDASE---VQRDPRAGSTP-LAEDVQVDPRKDSQSSSERFLEQSH ERK3_Mmus QF---SEHDWPIHNNFDIDE---VQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPA Erk4_Hsap LS---SDLEWRPDRCQDASE---VQRDPRAGSAP-LAEDVQVDPRKDSHSSSERFLEQSH Erk3_Hsap QF---SEHDWPVHNNFDIDE---VQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPA ERK3_Spur MSMDPNNLEDREEREGDAIEKGSVESD-NEGSEKS-EADDQISEKRNNQDDEEKRGSKED .: : .. * * *: * . * : *:. :: ... *: .. ERK4_Mmus SS---------------MERAFEADYGRS------------------------CDYKVGS ERK3_Mmus FDTSYSAEPCWQYPDHHENKYCDLECSHT------------------------CNYKTRS Erk4_Hsap SS---------------MERAFEADYGRS------------------------CDYKVGS Erk3_Hsap FDTNYSTEPCWQYSDHHENKYCDLECSHT------------------------CNYKTRS ERK3_Spur LL---------------MEKFEEDNTGDNNKKEEEKTEEGAMSKTARKESLVFMDYEAVE :: : : . . :*:. . ERK4_Mmus PSYLDKLLWRD-----------------NKPHHYSEPKLILDLSHW-KQA---------- ERK3_Mmus SPYLDNLVWRE-----------------SEVNHYYEPKLIIDLSNW-KEQ---------- Erk4_Hsap PSYLDKLLWRD-----------------NKPHHYSEPKLILDLSHW-KQA---------- Erk3_Hsap SSYLDNLVWRE-----------------SEVNHYYEPKLIIDLSNW-KEQ---------- ERK3_Spur KAFGDKLQKEKLNEQLSNREFEDGSVRKKESSENKELDLTDTLDILKKQAKSKGKTLDDC .: *:* .. .: . * .* *. *: ERK4_Mmus -----------ASAPPRAAVAADP---VSREDEPASLFLEIAQWVK-------------- ERK3_Mmus -----------SKEKSDKRGKSKC---ERNGLVKAQIAL--------------------- Erk4_Hsap -----------AGAPPTATGLADT---GAREDEPASLFLEIAQWVK-------------- Erk3_Hsap -----------SKEKSDKKGKSKC---ERNGLVKAQIAL--------------------- ERK3_Spur LELGTLRLSETSPTPKNTDVVLDKQLYVHKESKGNQEFNDKSEFVEQIRTDNTSVSNERM : . . . ERK4_Mmus --------STQSGSERASPPPDAPEPRLSASPPGHPTPIDGGASPQFDLDVFISRALKLC ERK3_Mmus --------------EEASQQLAE--R---------------ERGQGFDFDSFIAGTIQLS Erk4_Hsap --------STQGGPEHASPPADDPERRLSASPPGRPAPVDGGASPQFDLDVFISRALKLC Erk3_Hsap --------------EEASQQLAGKER---------------EKNQGFDFDSFIAGTIQLS ERK3_Spur GELQKVRCNTQTEKKQGRPKKPDLKEVLYVDIPKASASISPRSSPRGPGKETTTR----- :.. . . : ERK4_Mmus TKPE--DLPENKLGDLNGACISEH-----------------PGDLVQTEAFSK------- ERK3_Mmus AQHQSADV-VDKLNDLNSSVSQLELKSLISKSVSREKQEKGRANLAQLGALYQSSWDSQF Erk4_Hsap TKPE--DLPDNKLGDLNGACIPEH-----------------PGDLVQTEAFSK------- Erk3_Hsap SQHEPTDV-VDKLNDLNSSVSQLELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQF ERK3_Spur ------------------------------------------------------------ ERK4_Mmus ------------------------------------------------------------ ERK3_Mmus VSGGEECFLISQFCCEVRKDEHAEKENTYTSYLDKFFSRKEDSEMLETEPVEEGKRGERG Erk4_Hsap ------------------------------------------------------------ Erk3_Hsap VSGGEDCFFINQFC-EVRKDEQVEKENTYTSYLDKFFSRKEDTEMLETEPVEDGKLGERG ERK3_Spur ------------------------------------------------------------ ERK4_Mmus ------------------------------------------------------------ ERK3_Mmus REAGLLSGGGEFLLSKQLESIGTPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHKTYSSI Erk4_Hsap ------------------------------------------------------------ Erk3_Hsap HEEGFLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHQTYSSI ERK3_Spur -------------------------------------RNSLSPRERSVRPKKK-----DW ERK4_Mmus --ERW ERK3_Mmus LKHLN Erk4_Hsap --ERW Erk3_Hsap LKHLN ERK3_Spur FYSKH