CLUSTAL W (1.83) multiple sequence alignment Erk7_Hsap MC---------------------------------------------------------- CG2309_Dmel MANY-------------------------------------------------------- ERK7_Mmus MC---------------------------------------------------------- C05D10.2_Cele MT---------------------------------------------------------- Erk2_Ddis MS---------------------------------------------------------- 27541_Tthe MS---------------------------------------------------------- 28942_Tthe MSERTNMQGKLRKQKSEEKERHLKTNQQNLQEKLLEGEEKLTNQSRSGTIKMTLSCVFQQ 3210_Tthe MS---------------------------------------------------------- ERK7_Spur ------------------------------------------------------------ AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque ------------------------------------------------------------ AqueK124_Aque ------------------------------------------------------------ AqueK125_Aque TN---------------------------------------------------------- AqueK126_Aque MT---------------------------------------------------------- GK038_Glam MSD--------------------------------------------------------- Erk7_Hsap ------------------------------------------------------------ CG2309_Dmel ------------------------------------------------------------ ERK7_Mmus ------------------------------------------------------------ C05D10.2_Cele ------------------------------------------------------------ Erk2_Ddis ------------------------------------------------------------ 27541_Tthe ------------------------------------------------------------ 28942_Tthe SYQSFIKEIILIEALVANHQQKLSLGQQFQKQQRAAAKKTKIQPTTNKIDYKGRKQKFQQ 3210_Tthe ------------------------------------------------------------ ERK7_Spur ------------------------------------------------------------ AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque ------------------------------------------------------------ AqueK124_Aque ------------------------------------------------------------ AqueK125_Aque ------------------------------------------------------------ AqueK126_Aque ------------------------------------------------------------ GK038_Glam ------------------------------------------------------------ Erk7_Hsap -----------------------------------------------------TVVDPRI CG2309_Dmel -------------------------------------------QTAHAQERRIQELDQTV ERK7_Mmus -------------------------------------------A---------AEVDRHV C05D10.2_Cele -----------------------------------------------------DDVDTHI Erk2_Ddis -------------------------------------------S---------EDIDKHV 27541_Tthe -----------------------------------------------------EEIEPHI 28942_Tthe QTVIEKETKNTKEEDHQKFLEAEKEFFQLKFIQTVKIIERMSSN---------EEIEPHI 3210_Tthe -----------------------------------------------------EDIEPHV ERK7_Spur ------------------------------------------------------------ AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque ------------------------------------------------------------ AqueK124_Aque ------------------------------------------------------------ AqueK125_Aque -----------------------------------------------------R------ AqueK126_Aque -----------------------------------------------------AEIDRHI GK038_Glam -------------------------------------------D---------ESIDRHV Erk7_Hsap VRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGD CG2309_Dmel ESIFDVRKRMGKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQRTYREVIFLRAFRC ERK7_Mmus AQRYLIKRRLGKGAYGIVWKAMDRRTGEVVAIKKIFDAFRDQIDAQRTFREIMLLKEFGG C05D10.2_Cele HEKFDLQKRLGKGAYGIVWKAYDKRSRETVALKKIFDAFRNPTDSQRTFREVMFLQEFGK Erk2_Ddis LRKYEVLQKIGKGAYGIVWKAIDKKTKQTVALKKIFDAFQNATDAQRTFREIMFLQELHG 27541_Tthe MRKFEIIQKIGKGAYGIVWKAIDRKLRQVVAVKKVFDAFHNPTDAQRTFREVMFLQELNG 28942_Tthe LRKFEIIQKLGKGAYGIVWKAFCKKSKQIVALKKVFDAFHNATDAQRTFREVMFLQELNG 3210_Tthe LRRYEILSKLGRGAYGIVWKVYDKRTKQVLALKKIFDAFQNSTDAQRTFREIMFLQEL-D ERK7_Spur -----------------------------------------------------------D AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque ------------------------------------------------------------ AqueK124_Aque ------------------------------------------------------------ AqueK125_Aque -----------------------------------FPGCRCRS----------------- AqueK126_Aque LVKYDIKRRIGKGAYGIVWKSVDRRTGEIVALKKIFDAFANSTDAQRTFREILFLQAFSN GK038_Glam LRKYEIIHRVGKGAYGVVWKAVNRKTNETVALKKIFQAFQNDTDAQRTFREIMFLQEL-D Erk7_Hsap HPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGG-LLQDVHVRSIFY--------- CG2309_Dmel HPNIVRLVDIFKASNNLDFYLVFEFMESDLHNVIKRGN-VLKDVHKRFVMY--------- ERK7_Mmus HPNIIRLLDVIPAKNDRDIYLVFESMDTDLNAVIQKGR-LLKDIHKRCIFY--------- C05D10.2_Cele HPNVIKLYNIFRADNDRDIYLAFEFMEADLHNVIKKGS-ILKDVHKQYIMC--------- Erk2_Ddis HENIIKLLNVIKADNDRDIYLVFEHMETDLHAVIRA-K-ILEEIHKQYTIY--------- 27541_Tthe HENIVKLLNIIKAENNKDLYLVFDFMETDLHAVIRA-D-ILEEIHKKYVMY--------- 28942_Tthe HENIIRLINIIKAENNKDLYMVFDFMETDLHAVIRA-N-ILEEIHKQYVVY--------- 3210_Tthe HENIIKVINVIRAKNDRDIYVVFEYMDTDLHAVIRV-N-ILEDIHKQYIMY--------- ERK7_Spur HKNIVKLLNVMRAENDKDIYLVFEYMDTDLHAVIKKGG-ILKDIHKRYIMY--------- AqueK122_Aque ------------------------LINTDLHAVIKS-KIPVLSVHMQYIMS--------- AqueK123_Aque ------------------------LIETDLHAVIKS-K-IL-SVHMQYIMS--------- AqueK124_Aque -----------------------SLIDTDLHAVIKS-K-IL-SVHMQYIMS--------- AqueK125_Aque ----------SCSTKHCPCFLAVRKYDPDLCSTCGA-GD---NLEMKFTMCKNVSIQRGQ AqueK126_Aque HPNVIQLINVIRSSTDKDIYLVFEFMDTDLHAVIKS-K-ILQSVHMQYIMS--------- GK038_Glam HDNIIRLFNVLKAENDKDIYLVFEFLDSDLHQVIKS-N-ILEDIHKRYIIY--------- :.** . .:. : . Erk7_Hsap --QLLRATR---------FLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEG CG2309_Dmel --QLINAIK---------FIHSGNVIHRDLKPSNILIDSKCRLKVADFGLARTLSSRRIY ERK7_Mmus --QLLRATK---------FIHSGRVIHRDQKPANVLLDSACRVKLCDFGLARSLGDLPEG C05D10.2_Cele --QLFRAIR---------FLHSGNVLHRDLKPSNVLLDADCRVKLADFGLARSLSSLEDY Erk2_Ddis --QLLKALK---------YMHSANVLHRDIKPSNLLLNSECLVKVADFGLARSITSLESI 27541_Tthe --QILKALK---------YMHSGDLIHRDLKPSNILLNSECHVKLADFGLARSVAQKED- 28942_Tthe --QILKAMK---------YIHSGELIHRDLKPSNILLNSECLVKLADFGLARSVAVTDD- 3210_Tthe --QIFRAIK---------YIHSGELIHRDLKASNILVNSDCMVKVADFGLVRSIANQEN- ERK7_Spur --QLINATM---------YMHSGNVIHRDQKPSNILLDTECFVKVADFGLARSITQIDAV AqueK122_Aque --QLCRVLK---------YIHSGNVIHRDLKPSNILINSECFIKxxxxxxxxxxxxxxxx AqueK123_Aque --QLCRVLK---------YIHSGNVIHRDLKPSNILINSECFIKxxxxxxxxxxxxxxxx AqueK124_Aque --QLCRVFMYMYMYMYTWYIHSGNVIHRDLKPSNILINSECFIKLADFGLAHSLASTSNE AqueK125_Aque KKHLLMAP---------SDVAGWGIFLKDGAEKNEFISEYC-GELADFGLAHSLASTSNE AqueK126_Aque --QLCRVLK---------YIHSGNVIHRDLKPSNILINSECFIKLADFGLARSLASISNE GK038_Glam --QCVKALK---------YLHSAEILHRDLKPSNLLLNSECHMKMADFGLARSIAALSEP : . : . :. :* * ::. * : Erk7_Hsap -----------PEDQAVTEYVATRWYRAPEVLLS-------SHRYTLGVDMWSLGCILGE CG2309_Dmel DD--------LEQDGMLTDYVATRWYRAPEILVA-------SRNYTKGIDMWGLGCILGE ERK7_Mmus -----------PGGQALTEYVATRWYRAPEVLLS-------SRWYTPGVDMWSLGCILGE C05D10.2_Cele PE--------GQKMPDLTEYVATRWYRSPEILLA-------AKRYTKGVDMWSLGCILAE Erk2_Ddis A----------EANPVLTEYVATRWYRAPEILLG-------STKYTKGVDMWSIGCILGE 27541_Tthe -----------DAPPVLTEYVATRWYRAPEILLG-------STKYTKAVDMWSVGCILGE 28942_Tthe -----------DDNPVRTEYVATRWYRAPEILLG-------STKYAKAVDMWSIGCIVGE 3210_Tthe -----------GSTPILTEYIATRWYRAPEILLGIIELSQCSHTYTKGVDMWSIGCILGQ ERK7_Spur L---------SEDNPALTEYVATRWYRAPEILLA-------SKRYTKGVDMWSVGCIIGE AqueK122_Aque xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------xxxxxxxxxxxxxxxxxxx AqueK123_Aque xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------xxxxxxxxxxxxxxxxxxx AqueK124_Aque GSKGVGGDGVSDFNPAMTDYVATHWYRSPEILLG-------SRRYTRGVDMWSLGCILAE AqueK125_Aque GSKGVGGDGVNDFNPAMTDYVATRWYRSPEILLG-------SRRYTRGVDMWSLGCILAE AqueK126_Aque GSKGAGGDGVSDFNPAMTDYVATRWYRSPEILLG-------SRRYTRGVDMWSLGCILAE GK038_Glam S---------SATNPILTDYVATRWYRSPEILLG-------CTRYTKGVDMWAIGCILGE Erk7_Hsap MLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGS---RPRQTLDA CG2309_Dmel MIRQKPLFQGTSTVNQIEKIVTSLPNVTKLDIASIGPSFGSVLLSRNIQ--RDRRYSLDE ERK7_Mmus MLRGQPLFPGTSTFHQLELILKTIPLPSMEELQDLGSDYSALILQNLGS---RPQQTLDA C05D10.2_Cele MLIGRALFPGSSTINQIERIMNTIAKPSRADIASIGSHYAASVLEKMPQ---RPRKPLDL Erk2_Ddis LLGEKAMFPGNSTMNQLDLIIEVTGRPSAEDIEAIKSPFAGTMLESLPP---SNPRSLSD 27541_Tthe LIIGKSIFPGVSTLNQIERVLELTGKPKNEDIEAIESSLAWNILNSINI---TKQKKFEQ 28942_Tthe LITNRAIFPGNSTLNQIEKVLELTGKPTQEDIESLESQLAWNIISSINV---QKKKTFHQ 3210_Tthe LLLGKPIFAGTSTLNQLELILQVTGKPTYEDIEAIQSDLAITMLEAVQNNPTQNTKTLQQ ERK7_Spur LLKGKPMFPGSSTFNQLERIMAIIDPPTKKDIEAIQSDYxxxx---xxx---RHRQSIEE AqueK122_Aque xxxxRPLYPGSSTINQLNRIMSTLPPPSRQDVESIKSPYAKAILDQII------------ AqueK123_Aque xxxxxxxxxxxxxxxxxxxxxxxxPPCCGIDVQSIKSPYAKAILDQIIH---KRHKYLTD AqueK124_Aque MIASKPLYPGSSTINQLDRIMSTLPPPSRQDMESIKSPYAKAILDQIIH---KRHKYLTD AqueK125_Aque MIASRPLYPGSSTINQLNRIMSTLPPPSRQDVESIKSPYAKAILDQIIH---KRHKYLTD AqueK126_Aque MIASKPLYPGSSTINQLDRIMSTLPPPSRQDVESIKSPYAKAILDQIIH---KRHKYLTD GK038_Glam MLGGSPMFPGSSTMNQLDKIMEVTGRPTPEDIEATESPFASMMLDSLQP---KTGKALSE :: . Erk7_Hsap LLPPDTSPEALDL--LRRLLVFAPDKRLSATQALQHPYVQRFHCPSDEWAREADVRPRAH CG2309_Dmel MMKN-CCDDGISL--VKALLVLNPHNRLTAKEAIRHPYVSRFQYASAEMDLHMDVVPPLK ERK7_Mmus LLPPDTPPEALDL--LKRLLAFAPDKRLSAEQALQHPYVQRFHCPDREWARESDVRLPVH C05D10.2_Cele IITQ-SQTAAIDM--VQRLLIFAPQKRLTVEQCLVHPYVVQFHNPSEEPVLNYEVYPPLP Erk2_Ddis MYPS-ASVDALDL--LKKLLQFNPDKRITAEEALAHPFVTQFHNPAEEPHFDRIIKISID 27541_Tthe FFQG-ASPDALDL--LKKLLVFNPKLRLDAEQALQHRYVAEFHNPAEEHVCSKPIQIPLN 28942_Tthe MFPG-ASEEAIDL--IKKLLCFNPKNRLTVEQALEHPYVKDFHCPEEEIVCGRVIPISMN 3210_Tthe MIPM-ASDDALDL--LQNLLQFNPKKRITAEQALSHPYVRQFHNPNDEPVCGRIIQIPLD ERK7_Spur VLPXGAPADAIDL--VRKLLHFNPDKRLTAKQALSHPYVxxxxxQV-------------- AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque ILPQ-ADDISLDL--LNKLLNFNRNKRLTAENCLEHPYLSKFHDSDKEPVIWYQIVPVID AqueK124_Aque ILPQ-ADDISLDL--LNKLLNFNPNKRLTAENCLEHPYLSKFHDSDKKPVIGCQIVPVIE AqueK125_Aque ILPQ-ADPSKITHYTIDDSTNRFPGCRCRSSCSTKH-------CPCFLAVRECD------ AqueK126_Aque ILPQ-ADDISLDL--LNKLLNFNPNKRLTAENCLEHPYLSKFHDSDKEPVIGCQIVPVID GK038_Glam IYPN-APADALDL--LKKLLQFNPNKRLTAEQALEHPYLSKFHDPATEPSAPGPIKISID Erk7_Hsap EGVQLSVPEYRSRVYQMI-LECGGSSGTSREKG-------P--EGVSPSQAHLHKPRAD- CG2309_Dmel DHVRYDVDQYRNSLYELI-DRETSCSNRTVSN---------------------------- ERK7_Mmus EGDQLSAPEYRKRLYQII-LEQSGNSRSPREEG-------L---GVVASRAELRASPART C05D10.2_Cele DHIQLSIDDYRDRLYEMI-DEKKASFKRIQHEK-------I-----------------RP Erk2_Ddis DGQKFPIAEYRNRLYNDI-IKKKKEERKK------------------------------- 27541_Tthe DHEKFSIRKYRESLYADI-NERKKKQRIEWRNKYLRQLG-L-SIGDEGQQAAVQ----NG 28942_Tthe DNKKFSIKEYREALYNQI-YQEKRIKRQQNRDIYLKQQQQITTTGNG------------- 3210_Tthe DNKKYSMRFYRDKLYYEI-SPRKNVQQNGKQDSQL-------CSNFSESQDQIQ----QP ERK7_Spur ------------------------------------------------------------ AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque DNVQLTAHEYREQLYKDI-VLRHTELHPQ------------------------------- AqueK124_Aque DNVQLTAHEYREQLYKVYMILRHTELHPQ------------------------------- AqueK125_Aque ------------------------------------------------------------ AqueK126_Aque DNVQLTAHEYREQLYKDI-VLRHTELHPQ------------------------------- GK038_Glam DDDKRSVSEYRDLLYSEI-LRKKKEIRSK------------------------------- Erk7_Hsap ------------------------------------------------------------ CG2309_Dmel ------------------------------------------------------------ ERK7_Mmus QSLKSG------------------------------------------------------ C05D10.2_Cele Y----------------------------------------------------------- Erk2_Ddis ------------------------------------------------------------ 27541_Tthe Q---QI------------------------------------------------------ 28942_Tthe Q---VS------------------------------------------------------ 3210_Tthe Q---QIQHQQQTVNEQQVLQQRTNNQQFQSKDNSIQNARNNSNSSNSSQVKTNQSTYNNI ERK7_Spur ------------------------------------------------------------ AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque ------------------------------------------------------------ AqueK124_Aque ------------------------------------------------------------ AqueK125_Aque ------------------------------------------------------------ AqueK126_Aque ------------------------------------------------------------ GK038_Glam ------------------------------------------------------------ Erk7_Hsap ------------------------------------------------------------ CG2309_Dmel ------------------------------------------------------------ ERK7_Mmus ------------------------------------------------------------ C05D10.2_Cele ------------------------------------------------------------ Erk2_Ddis ------------------------------------------------------------ 27541_Tthe ------------------------------------------------------------ 28942_Tthe ------------------------------------------------------------ 3210_Tthe QSTLLRQKSNGIIQKQENGNMQQNQNIQSSDQQQNLAKEVIQQTSAVVAAQQAVLARKTQ ERK7_Spur ------------------------------------------------------------ AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque ------------------------------------------------------------ AqueK124_Aque ------------------------------------------------------------ AqueK125_Aque ------------------------------------------------------------ AqueK126_Aque ------------------------------------------------------------ GK038_Glam ------------------------------------------------------------ Erk7_Hsap ------------------------------------------------------------ CG2309_Dmel ------------------------------------------------------------ ERK7_Mmus ------------------------------------------------------------ C05D10.2_Cele ------------------------------------------------------------ Erk2_Ddis ------------------------------------------------------------ 27541_Tthe ------------------------------------------------------------ 28942_Tthe ------------------------------------------------------------ 3210_Tthe KQNSIQFQQNIYNEVQESIYQQVKTQKQQLYQQQLMQQQQQQQQKMQQQSQNQVISSKNQ ERK7_Spur ------------------------------------------------------------ AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque ------------------------------------------------------------ AqueK124_Aque ------------------------------------------------------------ AqueK125_Aque ------------------------------------------------------------ AqueK126_Aque ------------------------------------------------------------ GK038_Glam ------------------------------------------------------------ Erk7_Hsap ---------------------------PQLPSRTPVQGPRPRPQSSPGHDPAEH------ CG2309_Dmel -----------------------------------S---T--PSSNRDELPKPV----RV ERK7_Mmus -------------------------VLPQVPAETPARKRGPKPPRSPGHDPEHV------ C05D10.2_Cele -------------------------GEDKSR--API---AQA-----E------------ Erk2_Ddis -----------------------------QT--NPT---KPD------------------ 27541_Tthe -------------------------AEGQQQ--QPQ---QQVQQQQQQIQYSQY----QQ 28942_Tthe -------------------------QAGQSS--QPV---SSQ-----QIPSSSQ----ST 3210_Tthe IQYQSSNINKKQNEENEIRDPSENSIKQQQK--LYA---SPKAPSSNQILSNNQ----NL ERK7_Spur ------------------------------PA---------------------------- AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque -----------------------------SP--KPA---SPAPPPNPDVLVEDC----EL AqueK124_Aque -----------------------------SP--KPA---SPVPPSNPDILVEDC----KL AqueK125_Aque ----------------------------------------------PDLC-STCGAGDNL AqueK126_Aque -----------------------------SP--KPA---SPAPPSNPDVLVEDC----EL GK038_Glam ------------------------------------------------------------ Erk7_Hsap ------------ESPRAA------------------------------------------ CG2309_Dmel TKQARTTSAKQPTTSPAERK---------------------------------------- ERK7_Mmus ------------------------------------------------------------ C05D10.2_Cele -CSDTDYDTARSLQRT-------------------------------------------- Erk2_Ddis ------------------------------------------------------------ 27541_Tthe QSSTVKNNSAQQPEKRNARQ----------------------------VSQENIEQVSQQ 28942_Tthe QSSVTQQQQQQQQQEKSKNQ----YQSSSSQQQQAQQYQQQQSLQQQQVPQRQSSQSSQP 3210_Tthe QQTLTNNIMSTNNTNGIHNTISNGFAKRPTPF---------------------------- ERK7_Spur ------------------------------------------------------------ AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque ESCISDHSLVQSERGKKEKK---------------------------------------- AqueK124_Aque ESCILDHSLAQSERGKKEKK---------------------------------------- AqueK125_Aque EMKFTTCKNVSIQRGQKKHL---------------------------------------- AqueK126_Aque ESCISDHSLAQSERGKKEKK---------------------------------------- GK038_Glam ------------------------------------------------------------ Erk7_Hsap ------------------------------------------------------------ CG2309_Dmel ------------------------------------------------------------ ERK7_Mmus ------------------------------------------------------------ C05D10.2_Cele ------------------------------------------------------------ Erk2_Ddis ------------------------------------------------------------ 27541_Tthe QQQQQQSSNQQQYQQQQVRQQ--------NNREQAQQGSVQQ------------------ 28942_Tthe QSQQSIQQNQQKYQQSQQQQQRYFDQEKEQYKPNAQQQYLQQQQQLQQQQALQQQQMQKS 3210_Tthe ------------------------------------------------------------ ERK7_Spur ------------------------------------------------------------ AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque ------------------------------------------------------------ AqueK124_Aque ------------------------------------------------------------ AqueK125_Aque ------------------------------------------------------------ AqueK126_Aque ------------------------------------------------------------ GK038_Glam ------------------------------------------------------------ Erk7_Hsap -----------KNVPRQNSA------------------------PLLQTALLGNG-ERPP CG2309_Dmel ----------------KEPSS-----------------VDXAAAPPAPAATAPAV-PRKS ERK7_Mmus ------------EVRRQSSD------------------------PLFQLPPPGRG-ERPP C05D10.2_Cele -----------TSMDKNNSSS-----------------HDS----------------SSG Erk2_Ddis ------------------------------------------------------------ 27541_Tthe ----------SQQLQQQNSSV-----------------QSS--TQQQPSKYQPYQ-ANQY 28942_Tthe YYNSQNFNSSQVQVQQGNSQS-----------------TS----------------QGNN 3210_Tthe -------------LQSKNSSQ-----------------QT----------------SNST ERK7_Spur ------------------------------------------------------------ AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque -------------LK--EVG---------------GGYVSH-SSPSLPAKKTSDDSEGGG AqueK124_Aque -------------LK--EVG-------------------xH-SSPSLPVKKTSDDSEGGG AqueK125_Aque -------------LM--VLSDVAGWGIFLKDGAEKNEFISE-YCGEII---SQDEADRRG AqueK126_Aque -------------LK--EVGGVGGG----------GGYVSH-SSPSLPAKKTSDDSEGGG GK038_Glam ------------------------------------------------------------ Erk7_Hsap GAKEAPPL---------------------------------------------------- CG2309_Dmel GDKSVPKC---------------------------------------------------- ERK7_Mmus GATGQPPS---------------------------------------------------- C05D10.2_Cele --TLRERA---------------------------------------------------- Erk2_Ddis ------------------------------------------------------------ 27541_Tthe GAKYQPQA---------------------------------------------------- 28942_Tthe YSGYKSGS---------------------------------------------------- 3210_Tthe ALNQKSSSNQNSQQILQQQQVKQMLNSPNTQQMIQQQKSKEINQNIFSQQNIQNPHLLNG ERK7_Spur ------------------------------------------------------------ AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque GAEVKPRA---------------------------------------------------- AqueK124_Aque GAEVKPRA---------------------------------------------------- AqueK125_Aque --KVYDKY---------------------------------------------------- AqueK126_Aque GAEVKSRA---------------------------------------------------- GK038_Glam ------------------------------------------------------------ Erk7_Hsap -----------------------------TL-SL-VKPS------------GRGAAPSLT CG2309_Dmel -----------------------------QHNNA-AVQRELAAVA-AA--AAVARRKKSS ERK7_Mmus -----------------------------AP-SG-VKTQ------------VRAMAPSLT C05D10.2_Cele -----------------------------AS-AE-SRTSKDSNGE-MR--NGNGNTPSSI Erk2_Ddis ------------------------------------------------------------ 27541_Tthe -----------------------------NQ-QV-QQPQQQSLTQ-SQ--NNTQANGTTQ 28942_Tthe -----------------------------QA-ST-TNASSSAQYA-GYDDKKVLMNSSNQ 3210_Tthe NQYISSNNTINNNNDGQIDNVDEGITSPVSQ-NI-LKQSNSNRLI-KP--NNLKSNSSKA ERK7_Spur ------------------------------------------------------------ AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque -----------------------------FI-PF-MNRSKSAAVQ-AR--GGIMPHPSTP AqueK124_Aque -----------------------------FI-PF-MNRSKSAAVH-AR--EGIMPRPSTP AqueK125_Aque -----------------------------MC-SFLFNLNNDYVVDATR--KGN------- AqueK126_Aque -----------------------------FI-PF-MNRSKSAAVQ-AR--GGIMPRPSTP GK038_Glam ------------------------------------------------------------ Erk7_Hsap SQAA--------------AQVANQALIRGDWNRG----GGVRVASVQQVPPRLP------ CG2309_Dmel WQSQAQSQGKFHTEAKAHVQTAIQTQ--KDNIKD----SPPRMIQESQSLTEAKAPIPKN ERK7_Mmus SQAE--------------AQAANQALIRSDPARG----GGPRAVGARRVPSRLPREA--- C05D10.2_Cele KQRR-RS----------------------------------------------------- Erk2_Ddis ------T----------------------------------------------------- 27541_Tthe QTSQLKSQNAPM--YQTQSQFQNQNNVTAANNNGTGPNKAMYQTNYNNYIP----A--KN 28942_Tthe --IQNKNSSQVY---TQS----------------QGANQASSSNTQQQYLP----SSSNT 3210_Tthe LQSPTSNIVSPQ--HQ-------------------QQSSVSSQSTQQSHPSSAIQNQNSQ ERK7_Spur ---------------------------------------------------QRP------ AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque LQAH--------------SRTTVQPLSxSEEGCA----SASHMTTKKPVPPPPPPPPPHS AqueK124_Aque LQAH--------------SRTTVxAVITSEEGCA----SASHMTTKKPVPPPPPPPPPHS AqueK125_Aque ------------------------------------------------------------ AqueK126_Aque LQAH--------------SRTTVQPLSRARIGCA----SASHITTKKPVPPPPP-PPPHS GK038_Glam ------------------------------------------------------------ Erk7_Hsap ------------------------------------------------------------ CG2309_Dmel RYSNKMCQEKKYKKKHHSMSCITRDTFPSETEHRQQREERAYQRQMKRELQLKESYRRRI ERK7_Mmus ------------------------------------------------------------ C05D10.2_Cele ------------------------------------------------------------ Erk2_Ddis ------------------------------------------------------------ 27541_Tthe NYG--------------------------------------------------------- 28942_Tthe IYG--------------------------------------------------------- 3210_Tthe VQQ--------------------------------------------------------- ERK7_Spur ------------------------------------------------------------ AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque THG--------------------------------------------------------- AqueK124_Aque TYG--------------------------------------------------------- AqueK125_Aque ------------------------------------------------------------ AqueK126_Aque THG--------------------------------------------------------- GK038_Glam ------------------------------------------------------------ Erk7_Hsap ------------------------------------------------------------ CG2309_Dmel EAESEPLKET-------------------TEQESKT-IKVI-EQKVCEHTEKKADESLSK ERK7_Mmus ------------------------------------------------------------ C05D10.2_Cele -----------------------------V-ERA-------------------------- Erk2_Ddis ------------------------------------------------------------ 27541_Tthe ----QVPNSQNVAANGNAGAVSNNSSGVYK-SDAQNQ-PV-Q-------YG--------- 28942_Tthe ----QGVTNS-------------------I-ANSNNLYNQ-AQLNGSKQQSSSL------ 3210_Tthe ----KPASIN-------------------T-SQKYLQ-RIIQGATPSTQQENNLKQAISH ERK7_Spur ------------------------------------------------------------ AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque ----KPIDLT-------------------V-TSARIV-PISRL----------------- AqueK124_Aque ----KPIDLT-------------------V-TSARIV-PISRS----------------- AqueK125_Aque ------------------------------------------------------------ AqueK126_Aque ----KPIDLT-------------------V-TSARIV-PISRP----------------- GK038_Glam ------------------------------------------------------------ Erk7_Hsap ------------------------------------------------------------ CG2309_Dmel DQQKDSITFGTCVRERIHHLELEMEKCTEELVDFVELNADVLNYANVSTHLKKLQRSKES ERK7_Mmus ------------------------------------------------------------ C05D10.2_Cele ------------------------------------------------------------ Erk2_Ddis ------------------------------------------------------------ 27541_Tthe ------------------------------------------------------------ 28942_Tthe ------------------------------------------------------------ 3210_Tthe ------------------------------------------------------------ ERK7_Spur ------------------------------------------------------------ AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque ------------------------------------------------------------ AqueK124_Aque ------------------------------------------------------------ AqueK125_Aque ------------------------------------------------------------ AqueK126_Aque ------------------------------------------------------------ GK038_Glam ------------------------------------------------------------ Erk7_Hsap -------------------------------------------------------PEARP CG2309_Dmel DEKDEDDRRALPEGIGGPGSQNYEIFRQEQEKERQRQVQEFLARDETNEYDNLDLDHAYR ERK7_Mmus -------------------------------------------------------PEPRP C05D10.2_Cele --------------------------------------------RL--------FANIKP Erk2_Ddis ------------------------------------------------------------ 27541_Tthe ---------------------------------------SYVPQQK--------QYKYQP 28942_Tthe ----------------------------------GHTQNKYSSTQA--------YQQAQP 3210_Tthe ---------------------------QNQNNIIQQQYQNYINSNLSTN-----NNNSNP ERK7_Spur -------------------------------------------------------RHAQP AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque ---------------------------------------------------------PPP AqueK124_Aque ---------------------------------------------------------PPP AqueK125_Aque ------------------------------------------------------------ AqueK126_Aque ---------------------------------------------------------PPP GK038_Glam ------------------------------------------------------------ Erk7_Hsap GRRMFS-------TSA----LQGAQGGAR------------------------------- CG2309_Dmel AKYYTAYKEIGKELNP-APDSGGRDSGSEHSPGRDNYTTYADYFLKYTTPQQNWN----- ERK7_Mmus GRRMFG-------ISV----SQGAQGAAR------------------------------- C05D10.2_Cele ------------------------------------------------------------ Erk2_Ddis ------------------------------------------------------------ 27541_Tthe GSNATAS------QSQ----QNQPQGASG------------------------------- 28942_Tthe SKYMNQTQNAQKYVNN-NNNSNGQLGGSQNNIGGSQTNSQNHYQAAQQYLQQHMQ----- 3210_Tthe SHQM-NN------QNVQNTNVQSQSNGYSQNNNGYPTQSNSGYQQLNNGYPQHTNIYSQN ERK7_Spur GRKQFG-------XSK----TSGSSGAPR------------------------------- AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque SHQ-WKE------VNR----RVSRGGSSH------------------------------- AqueK124_Aque SHQ-WKK------VNR----RVSRGGPSR------------------------------- AqueK125_Aque --K-IRF------ANH----SVDPNCYAK------------------------------- AqueK126_Aque SHQ-WKE------VNR----RVSRGGPSR------------------------------- GK038_Glam ------------------------------------------------------------ Erk7_Hsap -------------------------------------ALLG------------------- CG2309_Dmel ------DLERANGLQREHDRIYGLFWLNDRRQEEKYRRKLA------------------- ERK7_Mmus -------------------------------------AALG------------------- C05D10.2_Cele ------------------------------------------------------------ Erk2_Ddis ------------------------------------------------------------ 27541_Tthe -------------------------------------ATYA------------------- 28942_Tthe ------QQQQQQQVQ-QPQTKYGVTYHHGHSQSSGSSNTFA------------------- 3210_Tthe SSNNIYTQQQQQQLS-G-QLKKGSTSINQY-----LTTTYKNPTQTMQQQMYKGNQIDFY ERK7_Spur -------------------------------------STFG------------------- AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque -------------------------------------YALG------------------- AqueK124_Aque -------------------------------------YASG------------------- AqueK125_Aque -------------------------------------VMIV------------------- AqueK126_Aque -------------------------------------YASG------------------- GK038_Glam ------------------------------------------------------------ Erk7_Hsap ------------------------------------------------------------ CG2309_Dmel ------------------------------------------------------------ ERK7_Mmus ------------------------------------------------------------ C05D10.2_Cele ------------------------------------------------------------ Erk2_Ddis ------------------------------------------------------------ 27541_Tthe ------------------------------------------------------------ 28942_Tthe ------------------------------------------------------------ 3210_Tthe SPNKSKVNTANYFGNRASVTKTMAQLNQKNNSNSAIIPNSNTSNQIQNNNQLNTNNNNNS ERK7_Spur ------------------------------------------------------------ AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque ------------------------------------------------------------ AqueK124_Aque ------------------------------------------------------------ AqueK125_Aque ------------------------------------------------------------ AqueK126_Aque ------------------------------------------------------------ GK038_Glam ------------------------------------------------------------ Erk7_Hsap ----------------GYSQAYG-----TV-----CH----------------------- CG2309_Dmel ----------------QNDQEEL-----PVH----HHKACRHRHH------------KP- ERK7_Mmus ----------------GYSQAYG-----TV-----CR----------------------- C05D10.2_Cele ------------------------------------------------------------ Erk2_Ddis ------------------------------------------------------------ 27541_Tthe ----------------NYVQRQQ-----QQQ-----QQG-----S------------NP- 28942_Tthe ----------------QYQQHYQ-----QQQ-----QRT-----T--------------- 3210_Tthe NKNYQTGQNGHIILNGNQSVSHNIHAQNSVSAGNMANNN-----LNSLNGQSSTKNKYSY ERK7_Spur ----------------SYSQAHG-----TI-----SA----------------------- AqueK122_Aque ------------------------------------------------------------ AqueK123_Aque ----------------TYTQTHx-----VI-----RR----------------------- AqueK124_Aque ----------------TYTQTHG-----II-----RR----------------------- AqueK125_Aque ----------------GGDHRIG-----IF-----AK----------------------- AqueK126_Aque ----------------TYTQTHG-----VI-----RR----------------------- GK038_Glam ------------------------------------------------------------ Erk7_Hsap --------------SALGHLPLLEGHHV CG2309_Dmel -NHHAPYDHMRPTEDD-IQEADSLPESN ERK7_Mmus --------------SALGRLPLLPGPRA C05D10.2_Cele --------------SK-ILHPHKLISNY Erk2_Ddis ---------------------TAPTLST 27541_Tthe -S--QTQAQQYYQMKN-QQQQQQIQQQQ 28942_Tthe -G--VTANHQRQPSNN-AQKVRKVEQKM 3210_Tthe SN--LLQNAQKLKANT-PSYHQLNSPKY ERK7_Spur --------------SSL--------AKL AqueK122_Aque --------------------------HK AqueK123_Aque --------------SDL---MTIKQNNW AqueK124_Aque --------------SDL---MAIKQNNW AqueK125_Aque --------------HNIELEEELFFDYR AqueK126_Aque --------------SDL---MTIKQNNW GK038_Glam ----------------------SLKEDE