CLUSTAL W (1.83) multiple sequence alignment FNIPK-A_Ddis MKKLV------------------------------------------------------- FNIPK-B_Ddis MNSYI------------------------------------------------------- FNIPK-C_Ddis MDNNNSNNKNNE------------------------------------------------ FNIPK-D_Ddis MDIISTTFDQINTHI--------------------------------------------- FNIPK-D_C2d_Ddis MDIISTTFDQINTHI--------------------------------------------- FNIPK-E_Ddis MQKIKEGYRRRHDYIIPKFISFQSGYLDFSFYQVSLKNVKYLDLSSYYQLHAPRRFRKIV *. FNIPK-A_Ddis ------------------------------------------------------------ FNIPK-B_Ddis ------------------------------------------------------------ FNIPK-C_Ddis ------------------------------------------------------------ FNIPK-D_Ddis ------------------------------------------------------------ FNIPK-D_C2d_Ddis ------------------------------------------------------------ FNIPK-E_Ddis EYLNLSYGQLLTLGTLPKYVMSLDLSSYNQLFTPGRLPIRVSLDLSSYNQLFTPGRLPDT FNIPK-A_Ddis ------------------------------------------------------------ FNIPK-B_Ddis ------------------------------------------------------------ FNIPK-C_Ddis ------------------------------------------------------------ FNIPK-D_Ddis ------------------------------------------------------------ FNIPK-D_C2d_Ddis ------------------------------------------------------------ FNIPK-E_Ddis VDYLKLSSYNQLFTPGTLPNHMVYLNLSSYNQPLTPGTLPNKVKYLVLSSYNQLLTPGTL FNIPK-A_Ddis ------------------------------------------------------------ FNIPK-B_Ddis ------------------------------------------------------------ FNIPK-C_Ddis -----------------------------------------ESNNIV------------- FNIPK-D_Ddis ----------------------------------------KFTNQKK------------- FNIPK-D_C2d_Ddis ----------------------------------------KFTNQKK------------- FNIPK-E_Ddis PNNVKYVDLSSYNKLLTPETLPNKVKYLVLSSYDQLLTPGTLPNNVKCVDLSSYDKLLTP FNIPK-A_Ddis ------------------------------------------------------------ FNIPK-B_Ddis ------------------------------------------------------------ FNIPK-C_Ddis ------------------------------------------------------------ FNIPK-D_Ddis ------------------------------------------------------------ FNIPK-D_C2d_Ddis ------------------------------------------------------------ FNIPK-E_Ddis GTLPNNVKYVDLSSYNKLLTPRTLPNNVECLVLSSYNQLLTPGILPNYVKYLDISSYNQL FNIPK-A_Ddis ------------------------------------------------------------ FNIPK-B_Ddis ------------------------------------------------------------ FNIPK-C_Ddis ---------------------------------------------------------IPI FNIPK-D_Ddis ---------------------------------------------------------IEF FNIPK-D_C2d_Ddis ---------------------------------------------------------IEF FNIPK-E_Ddis LTPGTLSNNVEYLDLSSYNQVLAPKTIPNNVKCLDCPSYKQSLISETFPNRVGDLELSDH FNIPK-A_Ddis --HK----ESQWEILSQLGTGAFGRVVKAKKINC-DGTGIIIDICAIKIIKK---SVFT- FNIPK-B_Ddis --YK----EEDWEIVETLKSNVFK-VNNKNNI---VLNGNSFKTCILKIIINKDKNVWK- FNIPK-C_Ddis LSEKEKKHLYEFEIIRILKKDEFSTTCKAKKLSG-QFNEKRVNFCIIKIIKK---RVKKF FNIPK-D_Ddis QNHI----EKEWEIITQLESNEQFTVYMSKKLKGPNFTNNRFGLCTVKKIKS---QYFN- FNIPK-D_C2d_Ddis QNHI----EKEWEIITQLESNEQFTVYMSKKLKGPNFTNNRFGLCTVKKIKS---QYFN- FNIPK-E_Ddis PKHV----NDNWEIIKPQKNISENKVYYTTKHKNA------------------------- ::**: . . .: FNIPK-A_Ddis ---KNEI----------EILKQLDHPLIVKYYGYGVGEIDDNIYIYMEYIDGY-PVSSI- FNIPK-B_Ddis ---EGQVL---------EKLK--NIDSIVKCYGWCC--NKHTTYIFIEYINGYTLEEYV- FNIPK-C_Ddis DSKKNEIIIEIDPRKEREILEKIKHICVLEYYGYSE--DEDNGYIYTEYIQGGIDIVET- FNIPK-D_Ddis ---ENEIL---------NHIKLRDNKYVLKYYGCGKDN-NQDVYIYLEFIEYSIPISKVK FNIPK-D_C2d_Ddis ---ENEIL---------NHIKLRDNKYVLKYYGCGKDN-NQDVYIYLEFIEYSIPISKVK FNIPK-E_Ddis -----KII---------DV--LNICKCSLKLYGYVKDR-NNEFNIYFEYIDKAIPLSRL- :: : :: ** .. *: *:*: FNIPK-A_Ddis -LRK----QPKNQF-PEDIISKIVIDLALILSYIHDNERKIIHRDLKCDNIMLVNDNTHS FNIPK-B_Ddis -LKNHP-------I-PEKELSEIIEDLIKSLASIHE--IGVIHRDLKLENVMFDKESN-- FNIPK-C_Ddis -VTNKLLKEHSHSFQSEDIIRRCAFQLVLLLNHLHNN-LHIIHGNINTDNVLIADQEF-- FNIPK-D_Ddis LIPNDSSIDNFNN-VSNTIIELVTCKLVESLNCIHKD-NKIVHGNIKGENILLVNDESE- FNIPK-D_C2d_Ddis LIPNDSSIDNFNN-VSNTIIELVTCKLVESLNCIHKD-NKIVHGNIKGENILLVNDESE- FNIPK-E_Ddis -LEKLNKKEQ----------FIVATEIIKSIKSIHE--MGIIHFDIKCQNILILYDENE- : : .: : :*. ::* ::: :*::: :. FNIPK-A_Ddis CDVNGNCSRNGGGSAKSANQSFFTEDCVCNVNGSGTDENCKSCKLKSKPIREIQGSCESC FNIPK-B_Ddis ------------------------------------------------------------ FNIPK-C_Ddis ------------------------------------------------------------ FNIPK-D_Ddis ------------------------------------------------------------ FNIPK-D_C2d_Ddis ------------------------------------------------------------ FNIPK-E_Ddis ------------------------------------------------------------ FNIPK-A_Ddis GSDLEQDSSSSSSSSSSTINNGQSSTCRLINCIYSVSKKIKLIDFGLS--KGCD------ FNIPK-B_Ddis --------------------------------------KWKLIDFGLS--FSFSPS---- FNIPK-C_Ddis --------------------------------------SLKLFDFSLSKDISYYSKDNNN FNIPK-D_Ddis -----------------------------------YGFSVKFINFSLN--IGYED----- FNIPK-D_C2d_Ddis -----------------------------------YGFSVKFINFSLN--IGYED----- FNIPK-E_Ddis -----------------------------------KMLPTDF---IKI--IGFDHS---- .: . FNIPK-A_Ddis ------------------------------------------------------------ FNIPK-B_Ddis ------------------------------------------------------------ FNIPK-C_Ddis NNNNNNNNNNNNNNNNNNNNNNNNNNNANNSNNNTLNNLSIVNNNSSSSSNDNSSEAEGG FNIPK-D_Ddis ------------------------------------------------------------ FNIPK-D_C2d_Ddis ------------------------------------------------------------ FNIPK-E_Ddis ------------------------------------------------------------ FNIPK-A_Ddis -----------------------------------------GDSKYYSLVG--TSTHMPP FNIPK-B_Ddis ----------------------------------------NDGSKCYTQCG--SIGYIPP FNIPK-C_Ddis GGGGEASITSTISTILSGSSSSQLSTPSTSLESSFSLEINLNDSSCY---------LIAP FNIPK-D_Ddis ------------------------------------------------------------ FNIPK-D_C2d_Ddis ------------------------------------------------------------ FNIPK-E_Ddis ----------------------------------------TLDSEVNSNIIGVTETHMAP FNIPK-A_Ddis EVAL----RNNTACRKSDIWSLGCTIIEMAGGNLFEK--DIH-------------GKPKI FNIPK-B_Ddis EIKL----G-GQCGRKSDIWIFGCLVIKMLGGELEETEIQIDGASFNNNNNKPNIWIPKI FNIPK-C_Ddis EIRNQQKITSKGLSKKSDIWGLGCLLLLMVGGDPKI---TTN-------------FEPTI FNIPK-D_Ddis -------------SIHLDMFNLGCVLIQMLGCDCTKDE-NID------------FLFSKI FNIPK-D_C2d_Ddis -------------SIHLDMFNLGCVLIQMLGCDCTKDE-NID------------FLFSKI FNIPK-E_Ddis EIKL----KNGKLGYKSDIWSLGCTLIEIVGGNLKLL--DIN-------------GIPLI : *:: :** :: : * : . . * FNIPK-A_Ddis PDHLSASCKNFIQRCLTIDPNHRDDIINLISHNFIDRNRINEEIKE-DISKSKIQ----- FNIPK-B_Ddis PPHASKFLQNFIQKCFFEEEVLRFDSITLIDHPFLSL----------------------- FNIPK-C_Ddis PYHLSNNCKNFIQKCLIQDPYHRWDTNLLLTHKFIEKTSFENSCNNQNNSSTTTTTTINT FNIPK-D_Ddis PNHLVEKFKKVISQLLSKNINNQILTDII---------------------SNKITTSLPK FNIPK-D_C2d_Ddis PNHLVEKFKKVISQLLSKNINNQILTDII---------------------SNKITTSLPK FNIPK-E_Ddis PDHLSNLFKNTIQHCLQINPNARFNANEL---------------------YNYVI----- * * :: *.: : : : : FNIPK-A_Ddis -----FDDEFNEIISPGDLDSVN----------EVVFGFDFNQTIIP------------- FNIPK-B_Ddis ----F-KSKGNMLYL-I-QRGHKRWMDITQKKKGI--------KIEGKTFTFE-----DN FNIPK-C_Ddis Y---SIENEENILLINGS-NGMNEFEEIPNYITTLKFQESFNMEIVNEMFTDSIVHLEFP FNIPK-D_Ddis YSTLIGEPNDGLIYI-GIQNNSD----------GLI-LPLFNQPICKKTFTYGVYYLSLS FNIPK-D_C2d_Ddis YSTLIGEPNDGLIYI-GIQNNSD----------GLI-LPLFNQPICKKTFTYGVYYLSLS FNIPK-E_Ddis -KDSIMEPIEP-IYL-P--NQCT------------N-LPLFNEVIVPSGF-FGIKYLELQ . : * FNIPK-A_Ddis ---------GTMNSVKKIEFGGSFNKE-------LLIDSLPSATSITFGARFNNGNKPFA FNIPK-B_Ddis DNKEPFGPGIVPDGTVELIFK-------KTFNQRLIPGSIPSTVQ---ILDFGVDGD--- FNIPK-C_Ddis QGFNKLDFNELPDFLSTLIYHGEFNIESNYHSKSLKPRDIPKSII---HLQLPNYNLKIR FNIPK-D_Ddis SFHRQLNVGVIPESIHTLE--------LASFNQTILPGVIPTSVR---TLKLPSYNKTLT FNIPK-D_C2d_Ddis SFHRQLNVGVIPESIHTLE--------LASFNQTILPGVIPTSVR---TLKLPSYNKTLT FNIPK-E_Ddis AYNQPIDSIFIFNGVEYLI--------LQSFNHPLGPGILPESIK---YLKLPSFNHPLK : : : :* : : . FNIPK-A_Ddis IGAIPSTCKSITFGWTY----------------------------NQPFYPGI---LPNS FNIPK-B_Ddis -------------S-FF----------------------------NQEMDDDL---F--- FNIPK-C_Ddis RNSIPDQTKFLILG-SDLGENEIQSLINLPPSIIDLEFGCDLELILNFLTQEM---IPSN FNIPK-D_Ddis QGSIPKGVRTLLLS-SF----------------------------NQPLTTDI---IPKT FNIPK-D_C2d_Ddis QGSIPKGVRTLLLS-SF----------------------------NQPLTTDI---IPKT FNIPK-E_Ddis EGSIPRSVIHLVFN-KF----------------------------NQFSLDEINLILPKF . : : : FNIPK-A_Ddis ------------------LKKLI---FQE------------------------------- FNIPK-B_Ddis ------------------------------------------------------------ FNIPK-C_Ddis ------------------ITSLK---INSQQIFLPFKRSNPFGLTNNIGNNNSNNGEQFN FNIPK-D_Ddis ------------------VTILK---LQS------------------------------- FNIPK-D_C2d_Ddis ------------------VTILK---LQS------------------------------- FNIPK-E_Ddis LDFGDAFDIEKYGILIPEDSILTLRTGFT------------------------------- FNIPK-A_Ddis ----------------------------------------------GGDFNRILEVGSLP FNIPK-B_Ddis ----------------------------------------------------------LD FNIPK-C_Ddis IPIDELPLSKDINDLMILETVEINNLNQLNSNKLLTLTNRVGKLIFSKEFDEPLTIGCIK FNIPK-D_Ddis -------------------------------------------------FNQPIEWGALP FNIPK-D_C2d_Ddis -------------------------------------------------FNQPIEWGALP FNIPK-E_Ddis -------------------------------------------------FNQPINQRYIP : FNIPK-A_Ddis S-SITTLIL---GDYDQKIEKGVLPSSLTILELGGEFNQPL------------------- FNIPK-B_Ddis C-DLKSLTL---GNA--------------------------------------------- FNIPK-C_Ddis SRSITSLKFNKGSRFNQLLVVGCLPVNLTSLEFGDRFNQALS------------------ FNIPK-D_Ddis C-SLVELSL---ASYKQPLQWGVIPYYISTLELPLASAPFS------------------- FNIPK-D_C2d_Ddis C-SLVELSL---ASYKQPLQWGVIPYYISTLELPLASAPFS------------------- FNIPK-E_Ddis S-SVTDLQL---YNYNLKILPHSIPRSIIMLTLGSNFTHFESLSNLPSSIINLTFGFKNN . .: * : FNIPK-A_Ddis ------EGSIPDSVTSLT------------------------------------------ FNIPK-B_Ddis ------------------------------------------------------------ FNIPK-C_Ddis ------VGCIPPKVTHLK------------------------------------------ FNIPK-D_Ddis ------EGSIPSGVSKLIQQGEIQQINKPIKINN--ENNQNYMS---------------- FNIPK-D_C2d_Ddis ------EGSIPSGVSKLIQQGEIQQINKPIKINN--ENNQNYMS---------------- FNIPK-E_Ddis FKIAELKKYIPSHITSININGKIVNFKKSSPLNTFNQSTDNILNNNEHFKEDWEIISTLG FNIPK-A_Ddis ------------------------------------------------------------ FNIPK-B_Ddis ------------------------------------------------------------ FNIPK-C_Ddis ------------------------------------------------------------ FNIPK-D_Ddis ------------------------------------------------------------ FNIPK-D_C2d_Ddis ------------------------------------------------------------ FNIPK-E_Ddis SGNFGKVFKARKINGIINGSKVSLCAIKKIEKKDKLKIKLSTEVEILNKLKDNEHSMKYY FNIPK-A_Ddis ------------------------------------------------------------ FNIPK-B_Ddis ------------------------------------------------------------ FNIPK-C_Ddis ------------------------------------------------------------ FNIPK-D_Ddis -CSQ--------------------------------NEFDSKLTLI-------------- FNIPK-D_C2d_Ddis -CSQ--------------------------------NEFDSKLTLI-------------- FNIPK-E_Ddis GYGYDEDDNLFIYTEYIEGSTSISDLIKKKPNNRFEEEEIKSLMIKIVKALSKIHESGVI FNIPK-A_Ddis ------------------------------------------------------------ FNIPK-B_Ddis ------------------------------------------------------------ FNIPK-C_Ddis ------------------------------------------------------------ FNIPK-D_Ddis ------------------------------------------------------------ FNIPK-D_C2d_Ddis ------------------------------------------------------------ FNIPK-E_Ddis HRDIKSDHIILAQDKNNETIVKFIDFGLSKQIEKNSKYYSFVGTDSHMAPEVKLQNGKAG FNIPK-A_Ddis ----------------------------------------------------LG------ FNIPK-B_Ddis --------------------------------------------------------FTHT FNIPK-C_Ddis ----------------------------------------------------FG------ FNIPK-D_Ddis ----------------------------------------------------LNSKITRE FNIPK-D_C2d_Ddis ----------------------------------------------------LNSKITRE FNIPK-E_Ddis SKSDIFCIGCTMIEMAGLNLCHSERDDKGIPSIPTHLSNSFKNIIQNCLKFDTNARHSVE FNIPK-A_Ddis ------------------------------YRFNKALTENCIPPNCKFLKFGSNFNKDLS FNIPK-B_Ddis LPYF-------------------------------------------------------- FNIPK-C_Ddis ------------------------------RCFNQPLKLGVIPDSCTFIQFGSQFNQSLE FNIPK-D_Ddis SLFF-------------------GLKYLELSTFNQSFETLPIPETVEYLKL-PMYNQPLT FNIPK-D_C2d_Ddis SLFF-------------------GLKYLELSTFNQSFETLPIPETVEYLKL-PMYNQPLT FNIPK-E_Ddis SLIITLSNIQIEGDSVFEKYLSPNLKKLELKT-NEPILLGSIGNEINYLSL-PI------ FNIPK-A_Ddis PGILPSSIETLILGYCFNKELVEGSLPLSITTLIYEHRDNQKKVSYDYKEVTNLSKDLEE FNIPK-B_Ddis ------------------------------------------------------------ FNIPK-C_Ddis PMVIPSSVKELIFGSQYNQPTIQGTFPDRIKKLVFSDDH--------------------- FNIPK-D_Ddis PKLLPSGIKFLILP-SFNHPIRGESIPPSVIHLVFNK----------------------- FNIPK-D_C2d_Ddis PKLLPSGIKFLILP-SFNHPIRGESIPPSVIHLVFNK----------------------- FNIPK-E_Ddis ----------------YNQMITPGALPPSVQYLLFNK----------------------- FNIPK-A_Ddis NEIIP-LTPESLPESITKLTIGKNQNHVIEFNCL-------------PP---DLQCLKYH FNIPK-B_Ddis -------------GSLCYLSLGRNRNALQ---N-------------LPP---TLETLKYY FNIPK-C_Ddis -DQF--HSQDTLPKSLVHLEFGESQNFN-QILFNQSSSNLIPSLTPPPPIYQKLTTFIFN FNIPK-D_Ddis --LFSV--IESIPSSVKYLDLGDEYYVY-PGHL-----------------LHSVLSFRSG FNIPK-D_C2d_Ddis --LFSV--IESIPSSVKYLDLGDEYYVY-PGHL-----------------LHSVLSFRSG FNIPK-E_Ddis --LNQYLECDSIPESVKYLDLGNEFDIE-KNGINLS--------------NESILVLRCG *: * :* . : : FNIPK-A_Ddis GGFIRPLIPRDLPSSITSVKLYNYNYEIKKTSIPKSVTSLQLGSRHNKFTQIQSLSNFHP FNIPK-B_Ddis GEVQTDLNIKSIPH-VKNLLIPFNNHSIIIDTIPPTVKYLAWGKL-KDLEAIETLKNLPP FNIPK-C_Ddis GYFTVPLKVFDLPLSITHLELPQYNDILEKDCIPSFVKTLVLGS---SFTIIESFINLPK FNIPK-D_Ddis LKF-RVTDPIPYSQSLTNLNLYNFNIELLKNGISSNVTSLTLGS---NFTNIESLSNLPS FNIPK-D_C2d_Ddis LKF-RVTDPIPYSQSLTNLNLYNFNIELLKNGISSNVTSLTLGS---NFTNIESLSNLPS FNIPK-E_Ddis FNFTQPVSQRLLPYSVTDLQLYNYNINLKRNSIPTLVTSLTLGS---NFTNIESLSFLPE . . :. : : * : *. *. * *. .: *::: : FNIPK-A_Ddis NMRDLKIYINDDDIDI-YNLKDIIP--QTITSLIINGDNIDLPIG--------------- FNIPK-B_Ddis SVNDLTFSCPPDVFDK-IQ-RKHIP--DSISIIIINQHVIELKNSDN------------- FNIPK-C_Ddis SITSLSFGCDENVIGL-IN-QSLIP--PNCNTLKINGQSISLPITQTLQIFKNPILPTES FNIPK-D_Ddis SVTNLSFGITTLNEKAISDITKYVK--STVTTITVNNEQIRKK----------------- FNIPK-D_C2d_Ddis SVTNLSFGITTLNEKAISDITKYVK--STVTTITVNNEQIRKK----------------- FNIPK-E_Ddis NVNSLAIGIKDEDEKLTKEIEKIIQTKKSITSFKINGIQ--------------------- .: .* : : . : . . : :* FNIPK-A_Ddis ------------------------------------------------------------ FNIPK-B_Ddis ------------------------------------------------------------ FNIPK-C_Ddis SLILSQQQQQQQQQQQMDLSVEYENQNFLTTNTLNQGSWIISINNFSNRKDQFYSPIFSL FNIPK-D_Ddis ------------------------------------------------------------ FNIPK-D_C2d_Ddis ------------------------------------------------------------ FNIPK-E_Ddis ------------------------------------------------------------ FNIPK-A_Ddis ------------------------------------------------------------ FNIPK-B_Ddis ------------------------------------------------SET--------- FNIPK-C_Ddis IGSNWRCKFYSNGKDASTSGKLSIFISNCDLLNNPFTIFLEKSISYKLTLINQKNPNESI FNIPK-D_Ddis ------------------------------------------------------------ FNIPK-D_C2d_Ddis ------------------------------------------------------------ FNIPK-E_Ddis ------------------------------------------------------------ FNIPK-A_Ddis ------------------------------------------------------------ FNIPK-B_Ddis ------------------------------------------------------------ FNIPK-C_Ddis QKSSSHTFSIKEFNHGYGSFIGLFSLLNPNNGFLVNNTIKVRIDAAPTSPLVNTYDKYNI FNIPK-D_Ddis ------------------------------------------------------------ FNIPK-D_C2d_Ddis ------------------------------------------------------------ FNIPK-E_Ddis ------------------------------------------------------------ FNIPK-A_Ddis ------------------------------------------------------------ FNIPK-B_Ddis ------------------------------------------------------------ FNIPK-C_Ddis GLNQAFSYSVPMMSKKSEPFISPIFMSCGRKWIIKIYPMGQPSSNYMSVFLEYRDEGEEN FNIPK-D_Ddis ------------------------------------------------------------ FNIPK-D_C2d_Ddis ------------------------------------------------------------ FNIPK-E_Ddis ------------------------------------------------------------ FNIPK-A_Ddis ------------------------------------------------------------ FNIPK-B_Ddis ------------------------------------------------------------ FNIPK-C_Ddis VHFSLELISQLYPEQSIKYWVQYRFNSKSNSFGYPKFIGVSTLMDPDMGFLVNDTIILNV FNIPK-D_Ddis ------------------------------------------------------------ FNIPK-D_C2d_Ddis ------------------------------------------------------------ FNIPK-E_Ddis ------------------------------------------------------------ FNIPK-A_Ddis ------------IEN FNIPK-B_Ddis ---Y----LKDNIVC FNIPK-C_Ddis SILQLKPIKKSFGFL FNIPK-D_Ddis -------------IN FNIPK-D_C2d_Ddis -------------IN FNIPK-E_Ddis -------------RN