CLUSTAL W (1.83) multiple sequence alignment STLK3_Hsap -------MAEPSGSPVH-VQLPQ-QAAPVTAAAAAAPAAATAAP--------APAA---- OSR1_Hsap -------MSEDS------------------------------------------------ OSR1_Mmus -------MSEDS------------------------------------------------ fray_Dmel -------MTSIPANL----------------------------------------SSNNV STLK3_Mmus -------MAEPSGSPVH-VQLSQ-QAAPVTAAAATAPAAATSAPAPAPAP--APAASAAP Y59A8B.23_Cele -------MNFTPNFFVV---------------AGSQP----SQPPPPPPP--QVSSPIAA DDB0229911_Ddis -------MSDDKYHHDKHHDKHHIDSKQSTAA-----ALSSSSTLASSSS--MTTTTTTT DDB0230012_Ddis -------MEINNSNNNNNYVCAQ-HNRIEHANHHDLPDSDSDSSSREEELMNSSGGGNGK FRAY_Spur ------------------------------------------------------------ CC1G_04381_Ccin -------MPDDASSH----------------------------P--------LAAHSLQH AqueK229_Aque -------MARVPEPV----------------------------------------V---- FRAY_b_Smoe GG--GVAME--------------------------------------------------- FRAY_d-2_Smoe -------ME--------------------------------------------------- FRAY_c_Smoe -------ME--------------------------------------------------- FRAY_d-1_Smoe RAAAATAME--------------------------------------------------- FRAY_a-1_Smoe -------MEERK------------------------------------------------ FRAY_a-2_Smoe -------MEERK------------------------------------------------ GK079_Glam -------M---------------------------------------------------- STLK3_Hsap -P--A-APAP-----------------APAPAAQAVGWPICRDAYELQEVIGSGATAVVQ OSR1_Hsap ---------------------------------SALPWSINRDDYELQEVIGSGATAVVQ OSR1_Mmus ---------------------------------SALPWSINRDDYELQEVIGSGATAVVQ fray_Dmel AG--A-ATLP-----------------GAAAPPEKYTWPNSKDDYELRDVIGVGATAVVH STLK3_Mmus AP--APAAAP-----------------APAPAAQAVGWPICRDAYELQEVIGSGATAVVQ Y59A8B.23_Cele AA--A-ASAA-----------------LVAQLNPADRWPTEPSAYKLDESIGVGATATVF DDB0229911_Ddis ST--T-TTAA-----------------SPITPKPRKNYPNSADQYELKETIGKGGSGLVQ DDB0230012_Ddis EPIGEKKKLPSHISEVISNERRESIIRELQQIKTISDYPSQANQYNLIEPIGEGTEGRVF FRAY_Spur --------------------------------------------------MCHGATATVH CC1G_04381_Ccin SM--GATPKF-----------------IGAVKDEWQLYSDRAEDYTIGEPIGFGASSIVY AqueK229_Aque -E--D-KDPP------------------SPPKPVSKTWSNKKEDYELKDVIGSGATAVVQ FRAY_b_Smoe ---------------------------------DKRQYPALASDYQLLEEVGQGVSATVY FRAY_d-2_Smoe ---------------------------------ARKPYPVAASDYRVLEEIGHGRNATVH FRAY_c_Smoe ---------------------------------DKRQYPALASDYQLLEEVGQGVSATVY FRAY_d-1_Smoe ---------------------------------AGKSYPVAASDYRVLEEIGHGRNATVH FRAY_a-1_Smoe ---------------------------------DKGKYPVVPADYKLLEEIGQGVSGLVF FRAY_a-2_Smoe ---------------------------------DKGKYPVVPADYKLLEEIGQGVSGLVF GK079_Glam ------------------------------------RFQGVASCYQLLSVIGVGAAGTVF : * . * STLK3_Hsap AA-LCKPRQE------RVAIKRINLEKCQ-TSMDELLKEIQAMSQCSHPNVVTYYTSFVV OSR1_Hsap AA-YCAPKKE------KVAIKRINLEKCQ-TSMDELLKEIQAMSQCHHPNIVSYYTSFVV OSR1_Mmus AA-YCAPKKE------RVAIKRINLEKCQ-TSMDELLKEIQAMSQCHHPNIVSYYTSFVV fray_Dmel GA-YCIPRNE------KCAIKRINLEKWN-TSMDELLKEIQAMSSCFHENVVTYHTSFVV STLK3_Mmus AA-LCKPRQE------RVAIKRINLEKCQ-TSMDELLKEIQAMSQCSHPNVVTYYTSFVV Y59A8B.23_Cele TA-YCLPRNE------KVAIKCINLEKCQ-TSVDELSHEIQAMSQCNHPNVVSYYTSFIA DDB0229911_Ddis RA-ICLPFQE------NVAIKIIDLEHCKNVSLEEIRKEIQAMSLCHHPNVVAYHTSFVY DDB0230012_Ddis KA-YCIPLKE------NVAIKVVELDKMDPQFVKDVIKEVKVMNGNNHPNLIHYHTSFLE FRAY_Spur KA-VCIPRDE------ECAIKRINLEKCN-TTMEELAKEIQAMCLCKHVNVVQYFTSFVV CC1G_04381_Ccin QA-LWKPADDPNAKPTPCALKVLDLDSLPPRSLQLLQRETTLMSLSKHPNVLRVRGSWMD AqueK229_Aque VA-VYVPRNE------KVAIKRIDLEQYK-SSMEELQKEINLMSNCNHPNVINYYTSFVV FRAY_b_Smoe RA-MCISFKE------IVAIKSLDLEKCS-SNLDEIRKEAKTMSLINHPNVVRAYCSFVV FRAY_d-2_Smoe RA-LCVPRGE------IVSIKSIDLEKCR-SDLDEVRREAQTLSLIDHPNVVAALALFIV FRAY_c_Smoe RA-MCISFKE------IVAIKSLDLEKCS-SNLDEIRKEAKTMSLINHPNVVRAYCSFVV FRAY_d-1_Smoe RA-LCVPRGE------IVSIKSIDLEKCR-SDLDEVRREAQTLSLIDHPNVVAALALFIV FRAY_a-1_Smoe RA-FCVPLGE------YVAVKQLDLEKCS-GTLDTIRKEAQTMSLINHSNVVKAHCSFVV FRAY_a-2_Smoe RA-FCVPLGE------YVAVKQLDLEKCS-GTLDTIRKEAQTMSLISHSNVVKAHCSFVV GK079_Glam KGQYTDPVTKQ---TSLCALKAINLDRTT-VRLETLQTECKLLAQSNHENIVGYYCSFVH . . . ::* ::*: :. : * : * *:: :: STLK3_Hsap KDELWLVMKLLSGGSMLDIIKYIVNR-G--EHKNGVLEEAIIATILKEVLEGLDYLHRNG OSR1_Hsap KDELWLVMKLLSGGSVLDIIKHIVAK-G--EHKSGVLDESTIATILREVLEGLEYLHKNG OSR1_Mmus KDELWLVMKLLSGGSVLDIIKHIVAK-G--EHKSGVLDEPTIATILREVLEGLEYLHKNG fray_Dmel REELWLVLRLLEGGSLLDIIKHKMRT-S--NCKQGVFDEATIATVLKEVLKGLEYFHSNG STLK3_Mmus KDELWLVMKLLSGGSMLDIIKYIVNR-G--EHKNGVLEEAIIATILKEVLEGLDYLHRNG Y59A8B.23_Cele QEELWVVMRLLNCGSMLDILKRKVKAIGKEQAQFGVLDEVSIATVLREVLKGLEYFHLNG DDB0229911_Ddis NESLWVIMDFLSAGSCSDIMRFSFPQ-G--------FEEHVIATILKEALKAICYFHKTG DDB0230012_Ddis NNQLWLVMDYLGGGSLADIMKFKYPD-G--------IPEVLAVTVLKSLLKGLEYLHSHQ FRAY_Spur KDEIWLVMRLLEAGSCLDLIKYMMKK-G--KGKGGLFEEAVIATILRETLQGLDYLHENG CC1G_04381_Ccin GHRLYIALRLMSKGSVADVMRYGWPG-G--------MDEEVVKCILRQTLKGLNYLHING AqueK229_Aque RHELWLVMKLMSGGSLLDIIKHVMTK-G---NKGGVLDEPVITTILYHVLQGLEYFHTNG FRAY_b_Smoe EHSLWVVMPYMAGGSCLHIMKAAYPD-G--------FEEAVIATVLKDTLKALEYLHRHG FRAY_d-2_Smoe GQRLWVVMPYMAAGSCLTIMRVARPY-G--------LDELLVATVLRECLKALDYLHFHG FRAY_c_Smoe EHSLWVVMPYMAGGSCLHIMKAAYPD-G--------FEEAVIATVLKDTLKALEYLHRHG FRAY_d-1_Smoe GQRLWVVMPYMAAGSCLTIMRVARPY-G--------LDEPLVATVLRECLKALDYLHFHG FRAY_a-1_Smoe SQHLWVVMPYMGGGSCLHIMKATSPD-G--------FDEPVIATILRDTLKALEYLHRQG FRAY_a-2_Smoe SQHLWVVMPYMGGGSCLHIMKATSPD-G--------FDEPVIATILRDTLKALEYLHRQG GK079_Glam QQYLWLVTPILEVN-IQDLLLKLAPN-G--------FDEGVISCIMYDILQALSYMEQNR . ::: : . :: . : * :: *:.: *:. STLK3_Hsap QIHRDLKAGNILLGEDGSVQIADFGVSAFLATG-GDVT---------------------- OSR1_Hsap QIHRDVKAGNILLGEDGSVQIADFGVSAFLATG-GDIT---------------------- OSR1_Mmus QIHRDVKAGNILLGEDGSVQIADFGVSAFLATG-GDIT---------------------- fray_Dmel QIHRDIKAGNILIGDDGTIQIADFGVSAWLATG-RDLS---------------------- STLK3_Mmus QIHRDLKAGNILLGEDGSVQIADFGVSAFLATG-GDVT---------------------- Y59A8B.23_Cele QIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLS---------------------- DDB0229911_Ddis RIHRDIKSGNILIDSNGNIQLSDFGVSATLIDT-GE------------------------ DDB0230012_Ddis RIHRDLKSDNILIGEDGAIELADFGVSAMFEKN-T------------------------- FRAY_Spur QLHRDIKAGNILLGSDGTVQLADFGVSSWIATG-GDLS---------------------- CC1G_04381_Ccin FIHRDIKAANLLIDDDGTVLLGDLGVAADLAED-PHHHVSSNKSKVHAIPASVALSPHHS AqueK229_Aque QIHRDLKAGNILIGEDGAVQLADFGVSNWLYGEAGGGK---------------------- FRAY_b_Smoe HIHRDVKVWNILIDSNGAIKLGDFGVSACLFDT-GD------------------------ FRAY_d-2_Smoe HIHRDVKAGNILVDQHGGVKLGDFGVSACLFDC-YN------------------------ FRAY_c_Smoe HIHRDVKVWNILIDSNGAIKLGDFGVSACLFDT-GD------------------------ FRAY_d-1_Smoe HIHRDVKAGNILVDQHGGVKLGDFGVSACLFDC-YN------------------------ FRAY_a-1_Smoe HIHRDVKAGNILIHENGAVKLGDFGVAAFMFDN-GD------------------------ FRAY_a-2_Smoe HIHRDVKAGNILIHENGAVKLGDFGVAAFMFDN-GD------------------------ GK079_Glam QVHRDIKTANILLNSSGTAKLADFGVSAFLCDD-SV------------------------ :***:* *:*: . * :.*:**: : STLK3_Hsap ---------------R--NKV-RKTFVGTPCW-------MAPEVMEQVRGYDFKADMWSF OSR1_Hsap ---------------R--NKV-RKTFVGTPCW-------MAPEVMEQVRGYDFKADIWSF OSR1_Mmus ---------------R--NKV-RKTFVGTPCW-------MAPEVMEQVRGYDFKADIWSF fray_Dmel ---------------R--QKV-RHTFVGTPCW-------MAPEVMEQDHGYDFKADIWSF STLK3_Mmus ---------------R--NKV-RKTFVGTPCW-------MAPEVMEQVRGYDFKADMWSF Y59A8B.23_Cele ---------------R--QKV-RHTFVGTPCW-------MAPEVMEQVQGYDFKADIWSL DDB0229911_Ddis -------------------TS-RNTFVGTPCW-------MAPEIMEQV-NYDYAVDIWSF DDB0230012_Ddis ------------------CCS-RKTIVGTPCW-------MAPEIISE-RGYNQGVDIWSF FRAY_Spur ---------------R--DKV-RTTFVGTPCW-------MAPEVMEQVTGYNFKADIWSF CC1G_04381_Ccin AITTGSRPKEATSPTRPGIGK-RKSFVGTPCW-------MAPELIQ-GKQYDASADIWSF AqueK229_Aque ---------------K--RNP-RYTFVGTPCW-------MAPEVMDQSVGYDSKADIWSF FRAY_b_Smoe ---------------R--QRS-RNTFVGTPCWCLPCECRMAPEVMEQIHGYDFKADIWSF FRAY_d-2_Smoe ---------------R--QIARRTTFAGTPCW-------MAPEVLDPVCGYDCSADIWSL FRAY_c_Smoe ---------------R--QRS-RNTFVGTPCW-------MAPEVMEQIHGYDFKADIWSF FRAY_d-1_Smoe ---------------R--QIARRTTFAGTPCW-------MAPEVLDPVCGYDCSADIWSL FRAY_a-1_Smoe ---------------R--QWS-RKTFVGTPCW-------MAPEVMEQINGYDFKADVWSF FRAY_a-2_Smoe ---------------R--QWS-RKTFVGTPCW-------MAPEVMEQINGYDFKADVWSF GK079_Glam ---------------E--RKM-RNTLVGSPLY-------MAPEVIS-MQGHDCKADIWSF * ::.*:* : ****::. :: .*:**: STLK3_Hsap GITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVE--DKEM-MKKYGKSFRKLLSL OSR1_Hsap GITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQ--DKEM-LKKYGKSFRKMISL OSR1_Mmus GITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQ--DKEM-LKKYGKSFRKMISL fray_Dmel GITAIEMATGTAPYHKYPPMKVLMLTLQNDPPTLDTGAD--DKDQ-YKAYGKTFRKMIVE STLK3_Mmus GITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVE--DKEM-MKKYGKSFRKLLSL Y59A8B.23_Cele GILAIELATGTAPYHKYPPMKVLMLTLQNDPPTLETNAE--RKDQ-YKAYGKSFKTLIRD DDB0229911_Ddis GITALELARGKAPFAEYPPMKVLLLTLQNPPPSLEG-------DG-ESKWSHSFKDLVEK DDB0230012_Ddis GITAIELIRGKPPGYDLPPSKVFMNLLFGNSPSLQE-------EEDKGVCSHLYKDLVDK FRAY_Spur GILAIELATGAAPYAKFPAMKESVLFLFR----------------------PTASKLLKS CC1G_04381_Ccin GITALELAQGHPPRFRESTQRVLLRTLREEPPTLDR-------DGGTFKFTRAFKEMIDS AqueK229_Aque GITALEMATGTAPYAKFPPMKVLMLTLENPPPTLDTCCELNGEDY-RKNYSKAFQKMVEK FRAY_b_Smoe GITALELAHGHAPFSKYPPMKVLLMTLQNAPPGLDY-------ER-DRRFSKSFKEMIAM FRAY_d-2_Smoe GITALELAQGHAPLSDLPPMKMVLVELSSPPPTLEP-------ER-AKVFSKSFKDFVAC FRAY_c_Smoe GITALELAHGHAPFSKYPPMKVLLMTLQNAPPGLDY-------ER-DRRFSKSFKEMIAM FRAY_d-1_Smoe GITALELAQGHAPLSDLPPMKMVLVELSGPPPTLEP-------ER-AKAFSKSFKDFVAC FRAY_a-1_Smoe GITALELAHGHAPFSKYPPLKVLLMTLQNAAPGLTY-------ER-DKRFSKSFKEMIAM FRAY_a-2_Smoe GITALELAHGHAPFSKYPPLKVLLMTLQNAAPGLTY-------ER-DKRFSKSFKEMIAM GK079_Glam GVCLIELAQGVPPNSNLPPMEVIVNIYQKDPPKLPA----------NKTFTKQFREVVDM *: :*: * .* .. . : .: STLK3_Hsap CLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTR-----TPDIAQR-AKKV------ OSR1_Hsap CLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTLQR-----APTISER-AKKV------ OSR1_Mmus CLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKILQR-----APTISER-SKKV------ fray_Dmel CLQKEPSKRPTASELLKHAFFKKAKDRKYLTQTLLQS-----GPSMETR-VHKAA----- STLK3_Mmus CLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTR-----TPDIAQR-AKKV------ Y59A8B.23_Cele CLQKDPAKRPTASELLKYSFFKKGKDKKYLVHTLIEN-----LASVPVVA-HHS------ DDB0229911_Ddis CLQKDPSKRPLPSKLLEHRFFKQAKKPDYLVQHILAK-----LPPLGQR-YQML------ DDB0230012_Ddis CLQKEPSKRPNASKLLEHKVFKQAKKNNYIVSHLLHG-----LTPCEDR-YRE-S----- FRAY_Spur QFFKKPRNKPTASELLKSQFFKKARDKKYLIESLIQE-----GLKVRQAQQQNV------ CC1G_04381_Ccin CLHKDPSKRPTAEQLLQSPFFRSAKKKSFLVNAILKD-----LPPLTKR-QER-R----- AqueK229_Aque CLQKDPSKRPSATELLKNPLFKKAKGKEFIKEVVLGN-----APSLSSR-ATKV------ FRAY_b_Smoe CLVKDPTKRPTAEKLLKHSFFKGAKSTEYLVRHVLEG-----LPPLWER-VRTL------ FRAY_d-2_Smoe CLQKEASKRPTAGKLLKHGFFKHAQSGEYLVEHLLRE-----LPPLWEQ-VREL------ FRAY_c_Smoe CLVKDPTKRPTAEKLLKHSFFKGAKSTEYLVRHVLEG-----LPPLWER-VRTL------ FRAY_d-1_Smoe CLQKEASKRPTAGKLLKHGFFKHAQSSEYLVAHLLRE-----LPPLWEQ-VKEL------ FRAY_a-1_Smoe CLVKDPTKRPTAEKLLKHSFFKSAKSSDYIVRHVLDG-----LPPLWER-VRDV------ FRAY_a-2_Smoe CLVKDPTKRPTAEKLLKHSFFKSAKSSDYIVRHVLDG-----LPPLWER-VRDV------ GK079_Glam CMVKNPRERASATKLLETKFFSKHGKKTTIDNMLIEYKKLMGAPVNGNN-DERVSIGNQI : *.. ::. . :**. .* : : STLK3_Hsap RRVPGS-SGHL-------------HK----TEDGDWEWSDDE------------------ OSR1_Hsap RRVPGS-SGRL-------------HK----TEDGGWEWSDDE------------------ OSR1_Mmus RRVPGS-SGRL-------------HK----TEDGGWEWSDDE------------------ fray_Dmel KRQPGA-SGRL-------------HR----TVTGEWVWSSEE------------------ STLK3_Mmus RRVPGS-SGHL-------------HK----TEDGDWEWSDDE------------------ Y59A8B.23_Cele SK-KVA-SGKL-------------RK----DAHGNWEFEYDS------------------ DDB0229911_Ddis SEDSFA-MLRNT-SSPQFDTG---HS----NSADEWIFPNEN------------------ DDB0230012_Ddis MS-PAS-SNTPS---P-DS-SRPSS----------------------------------- FRAY_Spur KRVPGS-SGRL-------------HR----TVDGAWEWSDEE------------------ CC1G_04381_Ccin ALPTVA-SPN---------------------SIDSWDFPTSLMTPTTSVLRYSALEELVA AqueK229_Aque KRVPGT-SGRL-------------HK----TEEGGWVWSDEE------------------ FRAY_b_Smoe KINDAA-RLAQK-KIP-YGEQEEQSQKEYKRGVSSWNFDVED------------------ FRAY_d-2_Smoe RNRDVA-ELGKKISLP-EGEQQK-QQ----EVVSEWNFCVAD------------------ FRAY_c_Smoe KINDAA-RLAQK-KIP-YGEQEEQSQKEYKRGVSSWNFDVED------------------ FRAY_d-1_Smoe RNRDVA-ELGKKISLP-EGEQQQQQQ----EVVSEWNFCVAD------------------ FRAY_a-1_Smoe KLKDAA-RLAEK-KTSTFEEQEEKSQNAYKRGVSGWNFDVED------------------ FRAY_a-2_Smoe KLKDAA-RLAEK-KTSTFEEQEEKSQNAYKRGVSGWNFDVED------------------ GK079_Glam LRMPVVISAT----IP--------AN----SNLESWDFNDTK------------------ STLK3_Hsap ------------------MDEKSE----EGKAAFSQEKSR---------RVKEENPE--- OSR1_Hsap ------------------FDEESE----EGKAAISQLRSP---------RVKESISN--- OSR1_Mmus ------------------FDEESE----EGRAAISQLRSP---------RVKDSLSS--- fray_Dmel ------------------EDNGGS----ATGSGTGDRKHP---------S---SDS---- STLK3_Mmus ------------------MDEKSE----EGKAAASQEKSR---------RVKEENSE--- Y59A8B.23_Cele ------------------PQESDD----DSDLE-DEEREK---------K--KKKAS--- DDB0229911_Ddis ------------------NDNNNSSTTT--TTTTTTTTNPSNNNNNNNNKTKENLTQSPF DDB0230012_Ddis -------------------PEHYN----HGNVVNSPLQKN---------IKPSSLNK--- FRAY_Spur ------------------LDAESE----EGKSA-SIGRSP---------RVRAQYKE--- CC1G_04381_Ccin AEDRELALQNQVHDAVFEFDNELTPSTQ----RFSVDQLP---------KVDEVHES--- AqueK229_Aque ------------------MTEEYEVEDDNKKTKLANKSTP---------SSSSGVTT--- FRAY_b_Smoe ------------------L---------KAQAALIQDDDD---------VYPEKNDE--- FRAY_d-2_Smoe ------------------S---------SSSSSTSG------------------------ FRAY_c_Smoe ------------------L---------KAQAALVIKL---------------------- FRAY_d-1_Smoe ------------------S---------SSSSSTSG------------------------ FRAY_a-1_Smoe ------------------L---------KAQA---------------------------- FRAY_a-2_Smoe ------------------L---------KAQA---------------------------- GK079_Glam ------------------TEAQIN----EAKALASVPSDQ---------KAPISKTA--- STLK3_Hsap --IAV------------------------------------------------------- OSR1_Hsap --SELFPTTDPVGTLLQVPEQ---------------------------I----------- OSR1_Mmus --SELFAAAEPMGTLLQVPEQ---------------------------I----------- fray_Dmel -DSEDRP----MNR-LERADS---------------------------S----------- STLK3_Mmus --ISV------------------------------------------------------- Y59A8B.23_Cele --ASA------------------------------------------------------- DDB0229911_Ddis ETPSHTPSTSPG--STPSHSRTSTPTSNHTA-----------------LGSSSTVVPPPV DDB0230012_Ddis -SSSS---LELKNKNLSNPDL--------------------------------------- FRAY_Spur -DLEN------------------------------------------------------- CC1G_04381_Ccin -DSS-------------------------------------------------------- AqueK229_Aque --LQASPSSSPA--PSSAPSSTSAPTQSQDPGASLTGELQVLMLKMKEL----------- FRAY_b_Smoe --NSS------------------------------------------------------- FRAY_d-2_Smoe ------------------------------------------------------------ FRAY_c_Smoe ------------------------------------------------------------ FRAY_d-1_Smoe ------------------------------------------------------------ FRAY_a-1_Smoe ------------------------------------------------------------ FRAY_a-2_Smoe ------------------------------------------------------------ GK079_Glam --TAI------------------------------------------------------- STLK3_Hsap ---------------------------SASTIPE-QIQSLSV------------------ OSR1_Hsap ---------------------SAHLPQPAGQIAT-QPTQVSLP----------------- OSR1_Mmus ---------------------SAHLPQPAGQMPT-QPAQVSLL----------------- fray_Dmel ---------------------DSDREEPSPEITH-SVSSATVT----------------- STLK3_Mmus ---------------------------NAGGIPE-QIQSLSV------------------ Y59A8B.23_Cele ---------------------------SGAGAAG-AAGGATG------------------ DDB0229911_Ddis VPLTLPTAIPVTAAAYHQQQQHHHLSHSSGSIPN-HNASSNLGASAHSNVHGLAHSSIHP DDB0230012_Ddis ---------------------------------------VNM------------------ FRAY_Spur ---------------------------EMGT-KT-ETESIKDE-------------DV-- CC1G_04381_Ccin ---------------------SHHLSTSPGTIAR-SLTSTSG------------------ AqueK229_Aque ---------------------QDQITDIRGQEQELMTQQIQNP-------------TL-- FRAY_b_Smoe ---------------------------FFKESPE-IVELPDH------------------ FRAY_d-2_Smoe ------------------------------------------------------------ FRAY_c_Smoe ------------------------------------VFNTL------------------- FRAY_d-1_Smoe ------------------------------------------------------------ FRAY_a-1_Smoe ------------------------------------------------------------ FRAY_a-2_Smoe ------------------------------------------------------------ GK079_Glam ------------------------------------------------------------ STLK3_Hsap --------------------------------------------------------HD-- OSR1_Hsap ------------------------------------------------------PTAE-- OSR1_Mmus ------------------------------------------------------PPAE-- fray_Dmel ------------------------------------------------------PGAP-- STLK3_Mmus --------------------------------------------------------HD-- Y59A8B.23_Cele --------------------------------------------------------GA-- DDB0229911_Ddis TSSAASTTVVNNTQQPQTLQPPQQQHQLQQPIKTPSPINAINIVKLNQSDLITPPKTSPK DDB0230012_Ddis ------------------------------------------------------PR---- FRAY_Spur ------------------------------------------------------KTVD-- CC1G_04381_Ccin --------------------------------------------------------TA-- AqueK229_Aque ------------------------------------------------------LTTQ-- FRAY_b_Smoe --------------------------------------------------------ER-- FRAY_d-2_Smoe ------------------------------------------------------------ FRAY_c_Smoe ------------------------------------------------------------ FRAY_d-1_Smoe ------------------------------------------------------------ FRAY_a-1_Smoe ------------------------------------------------------------ FRAY_a-2_Smoe ------------------------------------------------------------ GK079_Glam ------------------------------------------------------------ STLK3_Hsap --------------SQG------------------------------------------- OSR1_Hsap --------------PAK--------TA--------------------------------- OSR1_Mmus --------------PAK--------PA--------------------------------- fray_Dmel ---------A----AAG------AGAA--------------------------------- STLK3_Mmus --------------SQA------------------------------------------- Y59A8B.23_Cele --------------ASG------------------------------------------- DDB0229911_Ddis KEGSIPSSSSHGNI-PSLVTTSPKSPLQHQQQIPQQQQDPAMINSNNSSISSNGAYNREL DDB0230012_Ddis -----------------------------------AASHPVEL----------------- FRAY_Spur --------------APR--------SG--------------------------------- CC1G_04381_Ccin --------------ST----------N--------------------------------- AqueK229_Aque ---------SHQSKAVQLLNQRQEKEREQQQLIFQQQQIAVKL----------------- FRAY_b_Smoe --------------AQS------------------------------------------- FRAY_d-2_Smoe ------------------------------------------------------------ FRAY_c_Smoe ------------------------------------------------------------ FRAY_d-1_Smoe ------------------------------------------------------------ FRAY_a-1_Smoe ------------------------------------------------------------ FRAY_a-2_Smoe ------------------------------------------------------------ GK079_Glam ------------------------------------------------------------ STLK3_Hsap ----------PPNANEDYREASS--CAV-------------------------------- OSR1_Hsap ---------QALSSGSGSQE-TK--IPI-------------------------------- OSR1_Mmus ---------QAQSSGERSQE-TK--IPI-------------------------------- fray_Dmel QELTAGIA-QLPLPSEAAGE--A--PPV-------------------------------- STLK3_Mmus ----------QPNANEDYRE-GP--CAV-------------------------------- Y59A8B.23_Cele ----------APSAQEGGGATTPCPETL-------------------------------- DDB0229911_Ddis ISASGSALSKPPSPSSDKENNST--SKSNKSKSRQSSRASSLSESSDSTSHTSSSDEHSS DDB0230012_Ddis NALELSSG-SGP----LSQS-SD--LPH-------------------------------- FRAY_Spur ---------ETEQ-ISDGGD-QT--PPL-------------------------------- CC1G_04381_Ccin -EVS-----TAPS---SYVA---APSI--------------------------------- AqueK229_Aque QQLQISLQ-NDPQQKQDPSA-AK--KVL-------------------------------- FRAY_b_Smoe ----------PPSKPES------------------------------------------- FRAY_d-2_Smoe ------------------------------------------------------------ FRAY_c_Smoe ------------------------------------------------------------ FRAY_d-1_Smoe ------------------------------------------------------------ FRAY_a-1_Smoe ------------------------------------------------------------ FRAY_a-2_Smoe ------------------------------------------------------------ GK079_Glam ------------------------------------------------------------ STLK3_Hsap ------------------------------------------------------------ OSR1_Hsap ------------------------------------------------------------ OSR1_Mmus ------------------------------------------------------------ fray_Dmel ------------------------------------------------------------ STLK3_Mmus ------------------------------------------------------------ Y59A8B.23_Cele ------------------------------------------------------------ DDB0229911_Ddis RYESDRKSYKKKKSSSSSSNSKRDRERERDRDRSNKTYKNSRSRNVSRDRERERDRHNRS DDB0230012_Ddis ------------------------------------------------------------ FRAY_Spur ------------------------------------------------------------ CC1G_04381_Ccin ------HSYKKDS----------------------------------------------- AqueK229_Aque ------------------------------------------------------------ FRAY_b_Smoe ------------------------------------------------------------ FRAY_d-2_Smoe ------------------------------------------------------------ FRAY_c_Smoe ------------------------------------------------------------ FRAY_d-1_Smoe ------------------------------------------------------------ FRAY_a-1_Smoe ------------------------------------------------------------ FRAY_a-2_Smoe ------------------------------------------------------------ GK079_Glam ------------------------------------------------------------ STLK3_Hsap ------------------------------------------------------------ OSR1_Hsap ------------------------------------------------------------ OSR1_Mmus ------------------------------------------------------------ fray_Dmel ------------------------------------------------------------ STLK3_Mmus ------------------------------------------------------------ Y59A8B.23_Cele ------------------------------------------------------------ DDB0229911_Ddis RDRDRERERERDRDRERDRDRSRDRSRDRSRDRERDRSRDRSRDRDRSRDRSRDRSRERD DDB0230012_Ddis ------------------------------------------------------------ FRAY_Spur ------------------------------------------------------------ CC1G_04381_Ccin ------------------------------------------------------------ AqueK229_Aque ------------------------------------------------------------ FRAY_b_Smoe ------------------------------------------------------------ FRAY_d-2_Smoe ------------------------------------------------------------ FRAY_c_Smoe ------------------------------------------------------------ FRAY_d-1_Smoe ------------------------------------------------------------ FRAY_a-1_Smoe ------------------------------------------------------------ FRAY_a-2_Smoe ------------------------------------------------------------ GK079_Glam ------------------------------------------------------------ STLK3_Hsap --------------------------------NLVLRLRNSRKELNDIRFEFTPGRD--- OSR1_Hsap --------------------------------SLVLRLRNSKKELNDIRFEFTPGRD--- OSR1_Mmus --------------------------------SLVLRLRNSKKELNDIRFEFTPGRD--- fray_Dmel --------------------------------NLVLRMRNLRRELHDIRFEFVVGKD--- STLK3_Mmus --------------------------------NLVLRLRNSRKELNDIRFEFTPGRD--- Y59A8B.23_Cele --------------------------------NMVLRVRNQQRELNDIKFDYTKSAD--- DDB0229911_Ddis RDRSRDRSRDRSRSRDSDSRDRSRDRSRSHSNRRRSRSRDSRNKSRDRSSDSDRSRDRSR DDB0230012_Ddis --------------------------------GHLHKIGTPKKKH--------------- FRAY_Spur --------------------------------SLILRLRNASKELHDIRFEFKAGQD--- CC1G_04381_Ccin -----------------------------------SRPSTGYSSSNHSNYDFDSASN--- AqueK229_Aque --------------------------------KIALRKRTEQNQLKDIKFDYIIGTD--- FRAY_b_Smoe ------------------------------------------------------------ FRAY_d-2_Smoe ------------------------------------------------------------ FRAY_c_Smoe ------------------------------------------------------------ FRAY_d-1_Smoe ------------------------------------------------------------ FRAY_a-1_Smoe ------------------------------------------------------------ FRAY_a-2_Smoe ------------------------------------------------------------ GK079_Glam ------------------------------------------------------------ STLK3_Hsap -----------TADG-----------------------------VSQE-------L---F OSR1_Hsap -----------TAEG-----------------------------VSQE-------L---I OSR1_Mmus -----------TAEG-----------------------------VSQE-------L---I fray_Dmel -----------TAEG-----------------------------IATE-------L---V STLK3_Mmus -----------TADG-----------------------------VSQE-------L---F Y59A8B.23_Cele -----------TVEG-----------------------------IAHE-------L---V DDB0229911_Ddis DRDYKSSKYKKSSRGTSGRKNNKIQSKLDSQATHISYLEDKISTLTNW-------L---Q DDB0230012_Ddis ------------------------------------------------------------ FRAY_Spur -----------TPNG-----------------------------LSQE-------L---V CC1G_04381_Ccin -----------PADA-----------------TILP-THKTAPNLSQLSSSHHKKLSSAA AqueK229_Aque -----------TADA-----------------------------IAKD-------L---L FRAY_b_Smoe ------------ATD--------------------------------------------- FRAY_d-2_Smoe ------------------------------------------------------------ FRAY_c_Smoe ------------LKF--------------------------------------------- FRAY_d-1_Smoe ------------------------------------------------------------ FRAY_a-1_Smoe ------------------------------------------------------------ FRAY_a-2_Smoe ------------------------------------------------------------ GK079_Glam --------------D-----------------------------VEG------------- STLK3_Hsap SAGLVDGHDVVIVA-------ANL-QKIVDDPK----------------------ALKTL OSR1_Hsap SAGLVDGRDLVIVA-------ANL-QKIVEEPQ----------------------SNRSV OSR1_Mmus SAGLVDGRDLVIVA-------ANL-QKIVEEPQ----------------------SNRSV fray_Dmel DAGLVDALDTQPMA-------THL-DQLIAASA----------------------TMKTI STLK3_Mmus SAGLVDGHDVVIVA-------ANL-QKIVDDPK----------------------ALKTL Y59A8B.23_Cele TAELIDCHDLVIVA-------ANL-QKLIDFAE-------------------SKSDRRSI DDB0229911_Ddis QQNLLNTSNGQVLSPTDPNLVSKL-QTQLDVLQS------------------ENSYLRNE DDB0230012_Ddis ----------------------------------SPSGSIGD-SHGS------------I FRAY_Spur KEGLVDGRDVIVVA-------ANL-EKVVQNRE-----------------------CKSM CC1G_04381_Ccin SDSDLRGLDGVKAS-------KSVWKKFKDNLKRPGTSSSGYSAAGEESPVSRSLDKASV AqueK229_Aque AAGLLEGRELVVVA-------ANI-SKLIENPS------------------------QKV FRAY_b_Smoe ------------------------------------------------------------ FRAY_d-2_Smoe ------------------------------------------------------------ FRAY_c_Smoe ------------------------------------------------------------ FRAY_d-1_Smoe ------------------------------------------------------------ FRAY_a-1_Smoe ------------------------------------------------------------ FRAY_a-2_Smoe ------------------------------------------------------------ GK079_Glam -----DVSDVGTVAM------TAL-TELIKGYR----------------------TLQAE STLK3_Hsap TFKLASGCDGSEIPDE-----------VKLIGFA----QL-------------------- OSR1_Hsap TFKLASGVEGSDIPDD-----------GKLIGFA----QL-------------------- OSR1_Mmus TFKLASGVEGSDIPDD-----------GKLIGFA----QL-------------------- fray_Dmel TFQLSSGVQPGEVPDE-----------RSLVGYA----QIS------------------- STLK3_Mmus TFKLASGCDGSEIPDE-----------VKLIGFA----QL-------------------- Y59A8B.23_Cele TFALNSGVHANEIPDE-----------RTLTGFA----QIS------------------- DDB0229911_Ddis NINLKTIVNGSNSTNNSLNQSSGMAFRNSVSSLH----QLNMS---N------------- DDB0230012_Ddis SPP------LSTSPEK-----------ERKKGFFNHFRRHSIAKLFGSPKEGDHNHQHHK FRAY_Spur TFRLNSGCEVNEVPDD-----------KALIGFA----QL-------------------- CC1G_04381_Ccin LSGLFTSVSKSSVTNG------------------------------G------------- AqueK229_Aque TFQV--GNVPQEQLDD-----------KKLIGYA----QLYV------------------ FRAY_b_Smoe --------VSSAL----------------------------------------------- FRAY_d-2_Smoe --------KGEAK----------------------------------------------- FRAY_c_Smoe --------AGSDS----------------------------------------------- FRAY_d-1_Smoe --------KGEAK----------------------------------------------- FRAY_a-1_Smoe ------------------------------------------------------------ FRAY_a-2_Smoe ------------------------------------------------------------ GK079_Glam NAKLKE------T--N-----------EKLIRRI----RMF-----S------------- STLK3_Hsap -------------------------SVS OSR1_Hsap -------------------------SIS OSR1_Mmus -------------------------SIS fray_Dmel -------------------------ITD STLK3_Mmus -------------------------SVS Y59A8B.23_Cele -------------------------LLD DDB0229911_Ddis ------------------SSNNSRPQTQ DDB0230012_Ddis SEGDHEHHHFHFPWKHHHHSSSNNHVET FRAY_Spur -------------------------TVS CC1G_04381_Ccin ------------------RPSTATSGKY AqueK229_Aque -----------------------VNTDK FRAY_b_Smoe ---------------------FPVDFLC FRAY_d-2_Smoe ---------------------PEEEEKK FRAY_c_Smoe ---------------------RRRRRVS FRAY_d-1_Smoe ---------------------PEEEEKK FRAY_a-1_Smoe ------------------------AMVT FRAY_a-2_Smoe ------------------------AMVT GK079_Glam ------------------DQKRESEGNN