CLUSTAL W (1.83) multiple sequence alignment kin-22_Cele ------------------------------------------------------------ Src42A_Dmel ------------------------------------------------------------ FRK_Mmus ------------------------------------------------------------ FRK_Hsap ------------------------------------------------------------ Frk_Spur ------------------------------------------------------------ AqueK408_Aque ------------------------------------------------------------ AqueK409_Aque ------------------------------------------------------------ AqueK410_Aque ------------------------------------------------------------ AqueK411_Aque MSKARVDDHYLYQWIKDSSLLVNDIHTQSSRQTQASKSSSTSSPNLQSMVTMYLLHAKYL AqueK412_Aque ------------------------------------------------------------ kin-22_Cele --------------------------------------------------MGSC------ Src42A_Dmel --------------------------------------------------MGNC------ FRK_Mmus --------------------------------------------------MGSVCVRLWA FRK_Hsap --------------------------------------------------MSNICQRLWE Frk_Spur ------------------------------------------------------------ AqueK408_Aque --------------------------------------------------MGCK------ AqueK409_Aque --------------------------------------------------MGCC------ AqueK410_Aque --------------------------------------------------M--------- AqueK411_Aque DYSVQSDCSGLDSGSSLKLVECEVQLTVLDWTLRLSIADTTHSFWRIYRAMGCC------ AqueK412_Aque --------------------------------------------------MGCC------ kin-22_Cele ---------IGKEDPPP-GATSPVHT-S-STLG--------------------------- Src42A_Dmel ---------LTTQKGEPDKPADRIKLDDPPTIG--------------------VGVGVPQ FRK_Mmus YLQPFLPCWSQEADKS-VVI--E-----------------------------NPG----- FRK_Hsap YLEPYLPCLSTEADKS-TVI--E-----------------------------NPG----- Frk_Spur ------------------------------------------------------------ AqueK408_Aque ---------GSKTSGD-NAVRAKEVTD-------------------------GKG--IPY AqueK409_Aque ---------ASKATND-ENTTNKNTTDG-NNVGGGGGGTG-GIVGS----------GVDA AqueK410_Aque ------------------------------------------------------------ AqueK411_Aque ---------SSNDSATSNKYKAKNSSDG-PGFS-------------------GPGSMGPP AqueK412_Aque ---------ASAPEQP-RKKSNSMSYT---NQGGGGGGVPVGGANSYQPKPMNPGGYPPS kin-22_Cele ----RESLPSHP---------------RIPSIGPIAA--SSSGNTIDKNQNISQSANFVA Src42A_Dmel I--PMPSHA-G----------------QPPEQIR-PV--P--QIP-ESETAGANAKIFVA FRK_Mmus --------------A-----------FCPPE-----A--P--R---SQEPERSHGQYFVA FRK_Hsap --------------A-----------LCSP-------------------QSQRHGHYFVA Frk_Spur ----------------------------------------------------------VA AqueK408_Aque QTQANQLSPQGHGGF-----------VQDPRFQG-NI--P--QPQPTRIEQEPNYPVYVG AqueK409_Aque RYHPNPQ----------------------PTVSL-S---G--NNNQNTSSVASSGPKFIA AqueK410_Aque ------------------------------------------------------------ AqueK411_Aque ----RQSYPAGPPGDF----------SRQGSFGR-THNTG-LGYSGNQTASPPRGPVYIA AqueK412_Aque AAYPSSAAPRGPPGYNMGGPPQIGGGAMVPQVGG-AV--P--HIGGGTMGGARSALMFIG kin-22_Cele LFQYDARTDDDLSFKKDDILEILNDTQGDWWFARHKATG-------RTGYIPSNYVAREK Src42A_Dmel LYDYDARTDEDLSFRKGEHLEILNDTQGDWWLARSKKTR-------SEGYIPSNYVAKLK FRK_Mmus LFDYQARTAEDLSFRAGDKLQVLDTSHEGWWLARHLEKKGTGLGQQLQGYIPSNYVAEDR FRK_Hsap LFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDR Frk_Spur LFDYEARTQDDLGFKKGEELEVQND-SGDWWLARSRLTG-------LEGYIPCNYVAKVQ AqueK408_Aque KYDYDSRTDDDLSFKKGNLLYIISTDEGDWWFARSKDTG-------KEGYIPSNYVAEYK AqueK409_Aque RFKYMARTAEDLSFQKGERLVVIGPLEGDWWMARSLATG-------SEGYIPRNYVAPIE AqueK410_Aque ------------------------------------------------------------ AqueK411_Aque LFDYDQRTSEDLSFRKGERLEILNDQDGDWWQAKSLDTG-------KEGYIPSNYVAEYK AqueK412_Aque LYRYEARTPEDLSFDKGDQLQIMNNSDGDWWLARSLRTG-------REGYIPSNYVAAME kin-22_Cele SIESQPWYFGKMRRIDAEKCLLHTLNEHGAFLVRDSESRQHDLSLSVRENDSVKHYRIRQ Src42A_Dmel SIEAEPWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQ FRK_Mmus SLQAEPWFFGAIKRADAEKQLLYSENQTGAFLIRESESQKGDFSLSVLDEGVVKHYRIRR FRK_Hsap SLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKR Frk_Spur SLESEPWFFGSIKRMDAEKKLLLSQNEHGSFLIRESESRVGDYSLSVRDGDTIKHYRIRQ AqueK408_Aque SLDAEEWYFGKLKRNEAEKQLMMPYNDYASYLVRDSETTPGDFSLSVRDTNRVRHYKIRR AqueK409_Aque SYEAEDWYFGDIARAEAEKLLMISTNVQGTFLLRISSSQKDALSLSLRDVDGVKHYRIRK AqueK410_Aque ---FLMWYFGKIKRVDAEKLLQLPINEVGAYLIRDSETNPGDYSLSIRDLERVRHYKIKR AqueK411_Aque TIQAEDWYFGPIKRAEAEKL-LRATTMRGTFLVRESESKPGDYSLSIQDIETVKHYRIRK AqueK412_Aque SVQAQDWFFGKIKRSDAEKKLLQIGNQSGTYLIRESESQPGNYSLSVRDGESVKHYRIRK *:* : * :*** . .::*:* *.: ***: : ::**:*:: kin-22_Cele LDHGGYFIARRRPFATLHDLIAHYQREADGLCVNLGAPCAKSEAPQTTTFTY--DDQWEV Src42A_Dmel LDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEI FRK_Mmus LDEGGFFLTRRKVFSTLNEFVNYYTTTSDGLCVKLEKPCLKIQVPTPFDLSYKTADQWEI FRK_Hsap LDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEI Frk_Spur LDEGGYFIARRCTFATLVELVQHYQRDADGLCVNLRRPCVLIEKPQTRGLSYNTVDQWEI AqueK408_Aque LDDGSFFVTRRVQFATIPELIMFYQRQADGLCTILKTPCRAVEKPQTAGLSRQANEEWEI AqueK409_Aque MDDGGFFITTRAVFNTLQEMVRHYMMEADGLAQRLSVPCPRVNQPSTIGLSY--RDEWEI AqueK410_Aque LDNGTFFITRKATFNTISELVSYYQRQADGLCSHLVKPCIEPEKPQTAGLSHAANEDWEI AqueK411_Aque LDEGGFFITRRAVFNTLKELVEYYMKDSDGLCCMLRSACTQIEKPQI-DLSHKVKDMWEI AqueK412_Aque VDSGGCYIAPRAMCKSLDDLVNHYKREADGLCCRLTVPCPKSDKPVTGGLSYNTKDEWEI :* * ::: : :: ::: .* :***. * .* : * :: : **: kin-22_Cele DRRSVRLIRQIGAGQFGEVWEGRWNVNVPVAVKKLKAGTADPTDFLAEAQIMKKLRHPKL Src42A_Dmel DRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKL FRK_Mmus DRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKSLRHPKL FRK_Hsap DRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKL Frk_Spur PRSSLQLKSLRGTGQFGEVWEGLWNNTTPVAIKTLKxx---------------------- AqueK408_Aque DRQQVKLLRRLGAGQFGEVWEGLWNGTTQVAVKTLKTGTMSPQEFLQEAALMKRLRHPKL AqueK409_Aque DRSTLQFNKKLGQGNFGEVWSGLWNETTPVAIKTLKPGTMEVNDFVKEAQVMKKIHHPHL AqueK410_Aque DRRTIQMKRRLGAGQFGEVWEGLWNGTTQVAVKTLKPGTMSPQEFLQEAGLMKKLRHPKL AqueK411_Aque PRESITLLRLLGTGQFGEVYEGLWNNTTPVAVKTLKTGTMQPQAFLEEAHIMKKLRHPKL AqueK412_Aque ERTSLRLINRLGAGQFGEVWEGLWNNTTSVAVKTLKIGTMSVEDFLSEAQIMKKLRHEKL * : : * *:**:*:.* ** .. **:*.** kin-22_Cele LSLYAVCTRDEPILIVTELMQE-NLLTFLQR---RGRQCQMPQLVEISAQVAAGMAYLEE Src42A_Dmel IQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLES FRK_Mmus IQLYAVCTLEDPIYIITELMRHGSLQEYLQN--DGGSKIHLIQQVDMAAQVASGMAYLES FRK_Hsap IQLYAVCTLEDPIYIITELMRHGSLQEYLQN--DTGSKIHLTQQVDMAAQVASGMAYLES Frk_Spur ---------------------------------xKGHSLQLRILIDMSAQVAAGMAYLES AqueK408_Aque IQLYAVCTKQDPIFIITELMKHGSLLDYLRA---DGRSLQQAQLIDMCAQVAAGMAYLEQ AqueK409_Aque LQLYAVCTLEEPIYIVTELMSHGSLLDYLRN--GKGRYVNVHQMIDMIAQISSGMAYLEE AqueK410_Aque IQLYAVCTEEEPIYIITELMKHGALLDYLRG---DGRSLQQAQLIDMCAQVAAGMAYLEQ AqueK411_Aque IQLYAVCTKEDPIYIITELMPKGALLSFLQS--SEGRRLQLPQLIDMAAQIAAGMAYLEM AqueK412_Aque IQLYAVCTQEEPIYIVTELMKNGSLLDYLQK--GAGRHLKLPELIDIGAQVANGMAYLEA * : ::: **:: ****** kin-22_Cele MNFIHRDLAARNILINNSLSVKIADFGLARILM--KENEYEARTGARFPIKWTAPEAANY Src42A_Dmel QNYIHRDLAARNVLVGDGNIVKIADFGLARLIK---EDEYEARVGARFPIKWTAPEAANY FRK_Mmus QNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIRT FRK_Hsap RNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRS Frk_Spur QNYIHRDLAARNVLVGENNICKVADFGLARVIK---DEIYESHVGAKFPIKWTAPEAANY AqueK408_Aque QNYIHRDLAARNILVGEHLICKVADFGLARVID---EDIYEAHTGAKFPIKWTAPEAAMY AqueK409_Aque HSYIHRDLAARNILVGEGNSCKVADFGLARVIK---EDIYSPKEGAKFPIKWTAPEAALY AqueK410_Aque QNYIHRDLAARNILVGEHLICKVADFGLARVID---EDIYEAHTGAKFPIKWTAPEAAMY AqueK411_Aque HNYIHRDLAARNILVGENNICKVADFGLARLIA---DDEYNAHEGAKFPIKWTAPEAALY AqueK412_Aque QHYIHRDLAARNVLVGEGNIVKIADFGLARLIN---DDEYCAREGAKFPIKWTAPEAALY :*********:*:.: *:*******:: :: * .: ::*:******* kin-22_Cele NRFTTKSDVWSFGILLTEIVTFGRLPYPGMTNAEVLQQVDAGYRMPCPAGCPVTLYDIMQ Src42A_Dmel SKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIML FRK_Mmus NKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLSQNYRLPQPSNCPQQFYSIML FRK_Hsap NKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIML Frk_Spur HSFTIKSDVWSFGILLTEIITYGRIPYPGMTNKEVLDCVDRGYRMPNPPGCPPELYEIML AqueK408_Aque NRFTIKADVWSFGIVLYEVITYGRFPYPGMTNAEVLEKLPQGYRMGCPTSCPKELHDVML AqueK409_Aque SRFTIKSDVWSFGVLVAEVVTKGAMPYPGMTNRQVLESVEAGYRMPKPDTCPDPLYSIMM AqueK410_Aque NRFTIKADVWSFGIVLYEVITYGRFPYPGMTNAQTLEAIQQGYRMPPPQNCPDKLYSVML AqueK411_Aque NRFSIKSDVWSFGVLLTELVTYGRIPYPGMSNAEVLQQLERGYRMPCPPNTHESLYQIML AqueK412_Aque SRFSIKSDVWSFGILLVELITHGRIPYPGMTNGEVLAKVEQGYRMPVPPGCPEPLYQIML *: *:******::: *::* * :**.**:. :.: : .**: * ::.:* kin-22_Cele QCWRSDPDKRPTFETLQWKLEDLFNLDSSEYKE-A-SINF Src42A_Dmel ECWHKDPMRRPTFETLQWKLEDFYTSDQSDYKE-A-Q-AY FRK_Mmus ECWNVEPKQRPTFETLHWKLEDYFETDCS-YSDTN-NFIN FRK_Hsap ECWNAEPKERPTFETLRWKLEDYFETDSS-YSDAN-NFIR Frk_Spur ECWKSKAMERPTFETLQWKLEEFFVMEGEQYRE-A-SSIR AqueK408_Aque ECWREDPSNRPTFESLQWRLEEFYTSTEGGYRE----PEP AqueK409_Aque ECWRHEPDDRPTFESLKYRLDDYYVSAAEGSYQ-Q--NVQ AqueK410_Aque DCWREEPETRPTFETLQWQLEEFYSTDDGGYRDPEQQPFR AqueK411_Aque DCWKRNPADRPTFEALQWRLEDFFVMDGSQYHH-A--AEL AqueK412_Aque DCWKQEADERPTFEYLHHTLNDYFVSAADTAY--R--MLT :**. .. ***** *: *:: :