CLUSTAL W (1.83) multiple sequence alignment GCN2_Hsap MAGGRGAPGRG------------------------------------------------R Gcn2_Dmel MADEKAK----------------------------------------------------- GCN2_Mmus MAGGRGASGRG------------------------------------------------R GCN2_Scer MSLSHLT----------------------------------------------------- Y81G3A.3_Cele MTKENQIV---------------------------------------------------L DDB0216407_Ddis MPPKPKQKAKQPSQQPPPPPPPAAAQLIEDILSSDEEEGGVKLPTKSSVKNALKKVKKER IfkB_Ddis ------------------------------------------------------------ 11434_Tthe MQLNNGSIA--------------------------------------------------F 18670_Tthe MNLQINI----------------------------------------------------- 21870_Tthe MNSKQTKGI--------------------------------------------------Q GCN2_Spur MDEEIQR----------------------------------------------------- CC1G_02807_Ccin MDSTE------------------------------------------------------- AqueK195_Aque MEDQ-------------------------------------------------------- AqueK194_Aque MEDQ-------------------------------------------------------- AqueK193_Aque MLASS------------------------------------------------------- PEKc_Smoe LQVYL------------------------------------------------------- PEKa_Smoe LQVYL------------------------------------------------------- GK065_Glam MDEET------------------------------------------------------- GCN2_Hsap D-EP-PE----------------------------------------SYPQRQDHELQAL Gcn2_Dmel ------E----------------------------------------SFRERQAQELEVI GCN2_Mmus A-EP-QE----------------------------------------SYSQRQDHELQAL GCN2_Scer -----LD----------------------------------------QYYEIQCNELEAI Y81G3A.3_Cele D-ER-VK----------------------------------------ENQHLQEEEKLAL DDB0216407_Ddis DREL-IR----------------------------------------QLKDQQDMELEAL IfkB_Ddis ------------------------------------------------------------ 11434_Tthe D-NQQLNSQTQ------------------------------------RVEENQGSLLSNL 18670_Tthe --------QIN------------------------------------TLWIDRQTILCFI 21870_Tthe D-QSS-QQQSQSSAPKLSKAQKRIKQKQEEFRARLEKNRPQPIDTLHQLNEALNVEIEKL GCN2_Spur ------R------------------------------------------QE-AMKELKKK CC1G_02807_Ccin --------------------------------------------------ELQQLEITAL AqueK195_Aque -----------------------------------------------SYEERQRDELEFL AqueK194_Aque -----------------------------------------------SYEERQRDELEFL AqueK193_Aque ------------------------------------------------IS---------- PEKc_Smoe ------------------------------------------------------------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam ------------------------------------------------WFRDVTDSIEVG GCN2_Hsap EAIYGADFQ-------------DL-RPDA-----------CG--P-V--KEPPEINLVLY Gcn2_Dmel KSIFGCDVE-------------DL-RPQA-----------NP--S-L--WKPTDIRIQLT GCN2_Mmus EAIYGSDFQ-------------DL-RPDA-----------RG--R-V--REPPEINLVLY GCN2_Scer RSIYMDDFT-------------DL-TKRK-----------SS----W--DKQPQIIFEIT Y81G3A.3_Cele DAVYLNQIT-------------YI-KA-------------HW--H-V--WVPTNCHILLK DDB0216407_Ddis QAIFNDEFI-------------TM-DPIIINRNMDTIIEGIK--P-I--RESARFRITIK IfkB_Ddis ------------------------------------------------------------ 11434_Tthe LSIIFSEQNLIALVIFLIGYFVGRRKRNK------------PLKN-D--EVQIQNE--E- 18670_Tthe GS-----YS----TILYIQDNRGSSKKQK------------QIAS-Q--DISAQQN--Q- 21870_Tthe RSIYMENMI-------------GL-PPEH---------------G-Y--YRSFQIN--LF GCN2_Spur KDLTKQDSD-------------ES-RESR-----------ER--H-N--SDPPGS-QSPT CC1G_02807_Ccin KSIFGNDFI-------------EC-PPPK-----------AW--KGA--ARLPEFIIQVT AqueK195_Aque QFVFMSDFE-------------DM-REKD-----------TW--K-I--QRPPEIMIKLT AqueK194_Aque QFVFMSDFE-------------DM-REKD-----------TW--K-I--QRPPEIMIKLT AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------------------------------------------------------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam RSLFQVNLP-------------PL-PKGS-----------SF--YQYSISFSPVFLIVEE GCN2_Hsap PQG-----LT---G--------EE-VYVKVDLRVKCPPTYPD------V-V-PEIELK-N Gcn2_Dmel PLR-----DSSNG---------LE-TYVCTKLHVTCPSKYPK------L-P-PKISLE-E GCN2_Mmus PQG-----LA---G--------EE-VYVQVELRVKCPPTYPD------V-V-PEIDLK-N GCN2_Scer LRS-----VD---K--------EP-VESSITLHFAMTPMYPY------T-A-PEIEFK-N Y81G3A.3_Cele ALD--SCFLNGDPL--------GK-SKLSVILHVKCSEDYPQ------R-K-PAVDLL-D DDB0216407_Ddis PYV--------GDD--------EK-CFVSIYLVVGFPEKYPV------V-L-PSIQVL-V IfkB_Ddis ------------------------------------------------------------ 11434_Tthe ---LQNKIFNSDSSQQGVTSTKQT-FNIE-----QNRSDFTGLNFDQNS-F-SQRGVI-E 18670_Tthe -----NKILQNDS---------------------QYALDYPN------F-P-KTQNKT-K 21870_Tthe PQQLKLKYQDENAS--------DQ-AEFYLFLIFNIPREYPD------Q-M-PKVSVK-S GCN2_Spur RKR-----VDSGS---------L---------DSS-DSSSPK------T-K-GKWQFD-Q CC1G_02807_Ccin N--------P---D--------YP-DKISVNLHVKLPKTYPH------L-ACPIFTLQKP AqueK195_Aque PQK-----SISTSV--------QR-LQISVKLHAKYSSDYPD------T-P-PQLDLI-E AqueK194_Aque PQK-----SISTSV--------QR-LQISVKLHAKYSSDYPD------T-P-PQLDLI-E AqueK193_Aque -------------------------------------SS--------------------- PEKc_Smoe -------------------------------LRLACGKKGP------------------- PEKa_Smoe -------------------------------LRLACGKKGP------------------- GK065_Glam DD-------P---V--------LQQKAVDAQVHISITSKPSN------VLGEHDISF-RD GCN2_Hsap AKGL-----------------------------------SNESVNLLKSRLEELAKK--- Gcn2_Dmel SKGM-----------------------------------SDQLLEALRNQLQAQSQE--- GCN2_Mmus AKGL-----------------------------------SNESVNLLKSHLEELAKK--- GCN2_Scer VQNV-----------------------------------MDSQLQMLKSEFKKIHNT--- Y81G3A.3_Cele PQGL-----------------------------------SKEDVQNLLTILRQMADT--- DDB0216407_Ddis NKGL-----------------------------------PQKKAIELEEKLIRESQG--- IfkB_Ddis ------------------------------------------------------------ 11434_Tthe SRKYSNQSGGNYNEDISS-ANSDI--SFQNNENQ-------------VKN---------- 18670_Tthe ----NKKKKSANGKEINQFNQSQAGLKNYSSEKHNIEYGSNEENILFKDSQSNIIQD--- 21870_Tthe FKGF-----------------------------------AKQDEQLLQEKLFDYALK--- GCN2_Spur VEKG-----------------------------------GDTRIR--------------- CC1G_02807_Ccin AKGL-----------------------------------TNDQVSKLQQIINAEAQK--- AqueK195_Aque PHLL-----------------------------------SKDLVKELLTEINDLAKS--- AqueK194_Aque PHLL-----------------------------------SKDLVKELLTEINDLAKS--- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ---------------------------------------LPNSLSELTSQLSQLGVR--- PEKa_Smoe ---------------------------------------LPNSLSELTSQLSQLGVR--- GK065_Glam VVFL-----------------------------------GEARLKLLIQLVDNLKNDSLT GCN2_Hsap -------------------HC-GEVMIFELAYHVQSFLSEH--NKPP---PK-SFHEEML Gcn2_Dmel -------------------LR-GEVMIYELAQTVQAFLLEH--NKPP---KG-SFYDQML GCN2_Mmus -------------------QC-GEVMIFELAHHVQSFLSEH--NKPP---PK-SFHEEML GCN2_Scer -------------------SR-GQEIIFEITSFTQEKLDEF-QNVVN---TQ-SLEDDRL Y81G3A.3_Cele -------------------WE-GCVVIAELAHRVREFLTDH--TPRP---AG-SFHDDML DDB0216407_Ddis -------------------KI-GNIMIFDLCEIAKDFLNEN--NFEP---TQ-SIHHDFR IfkB_Ddis ------------------------------------------------------------ 11434_Tthe -------------------------------THKNSYLEDHFE----DNNLS-SQG---- 18670_Tthe -------------------QS-TNPM-----NIKQSFSSLD-Y----KSPSL-EAL---- 21870_Tthe -------------------NS-GKEMLFDLILQSRDYVESA-Y-KFHHKCIK-NIDL--K GCN2_Spur ---------------------------------VRTF----------------------- CC1G_02807_Ccin -------------------QR-GTEMVFTIANTCQDWLVNN--VTPV---SG-SLAVQMT AqueK195_Aque -------------------RI-GEVMMLEIAQHVQSFLHKH--DR-P---PV-SLYEEMV AqueK194_Aque -------------------RI-GEVMMLEIAQHVQSFLHKH--DR-P---PV-SLYEEMV AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe -------------------DVFRENL-------LYKFLFMQ--IMP-------SWAEDLV PEKa_Smoe -------------------DVFRENL-------LYKFLFMQ--IMP-------SWAEDLV GK065_Glam LTDFINGVFLLTQNRMCDDKS-DNLLVF--PSGAESFIAPN--RVEL---HSHSAYTSLR GCN2_Hsap E-RRAQEEQ-QRLLEAKR-----KEEQEQREI-LHEIQ--RRKEEIKEEKKRKEM----- Gcn2_Dmel Q-DKQKRDQ-EL-QDIQR-----QRESLQRQTLIDEVE--RRKEMFKTEAKRRGE----- GCN2_Mmus E-RQAQEKQ-QRLLEARR-----KEEQEQREI-LHEIQ--RRKEEIKEEKKRKEM----- GCN2_Scer Q-RIKETKE-Q-LEKEER-----EKQQETIKK-RSDEQ--RRIDEIVQR----------- Y81G3A.3_Cele A-NKVRTEA-EK-QRKRL-----DTEQKELEL-LEEEM--RQRNAIEMEKTLNGT----- DDB0216407_Ddis S-HQQKISI-EISTNEQQQQQLQQLQQLQLQY-NNDTK--KEWESTLEESQLKEDRKNYR IfkB_Ddis ------------------------------------------------------------ 11434_Tthe -------------KSAVKNES--QVS-------NEN-S--KQL--IQQSQQIKF------ 18670_Tthe -------------EKL---------S-------KKS-L--KKL--GKEQKVK-P------ 21870_Tthe T-YQMKNED-IKQLQLIERKE--KEE-------LEERQ--KKKKELEEKQALKM------ GCN2_Spur ------SGS-NT-S----------RQLI--ETSHHNSH--RKARLVKQLSGGK------- CC1G_02807_Ccin Q-RALDEERNRKQREAEE-AA-REEERRKR-E-AEELEAQIEQDALRQLMAREQQ----- AqueK195_Aque K-RREKEAE-EESKKKFQEQEV-ARHQRQEEI-AQELQ--RRQDQLREK----------- AqueK194_Aque K-RREKEAE-EESKKKFQEQEV-ARHQRQEEI-AQELQ--RRQDQLREK----------- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe S-RQPQMFQ--------------------------------------------------- PEKa_Smoe S-RQPQMFQ--------------------------------------------------- GK065_Glam RSREVHALLQERLNQSDE--A-H--KNTQL-V-IN------------QVLAEH------- GCN2_Hsap -----AK-Q-----ERLEIASLSNQDHTSKK-------DPGGHRTAAILHGGSPDFVGNG Gcn2_Dmel -----PR-R----SM-SES----NPRHPSSS-------ESS------------------- GCN2_Mmus -----AK-Q-----ERLEITSLTNQDYASKR-------DPAGHRAAAILHGGSPDFVGNG GCN2_Scer ---ELEKRQD--DDDDLLFNRTTQLDLQPP----------------------S-EWVASG Y81G3A.3_Cele -----RQ-E----NE-TRI----I----------------G------------------- DDB0216407_Ddis LQKSIQRAQYEKERKKTIVNEFTNGPQ-SKL-------SKQ-----Q-RNIDY------- IfkB_Ddis ------------------------------------------------------------ 11434_Tthe -------GSDNQSSENQ---YKHYQ----G-ELALVPFKQ------N------------- 18670_Tthe -------TEQSDESFNL-IIREIDV----L-KCIFEDQ---------------------- 21870_Tthe -------LQQEKQREN--ILRMNENDEQKLRMQWLNERDK------I------------- GCN2_Spur --------------------------------------KD-------------------- CC1G_02807_Ccin ----FKS-RERANSETTEVPFMSDTPLETF----------------------SQ-DIHLG AqueK195_Aque ---LLQDFDEESSSDDELVTKNSNKQT-SQK-------DSD-----DITNPPL------- AqueK194_Aque ---LLQDFDEESSSDDELVTKNSNKPT-GQK-------DSD-----DITNPPL------- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------------------------------------------------------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam ---------EYIHTETKLIQHRGMGKIPPT----------------------VQ-NIQN- GCN2_Hsap KHRANSSGRSRR-----ER-QYSVCNSEDSP-------GSCEIL--YFN-MGSPDQLMVH Gcn2_Dmel -----------------EN-SSPYYRGHIYPSKCLD-HRNTETL--YFH--K-M-GRQIQ GCN2_Mmus KARTYSSGRSRR-----ER-QYSVCSGEPSP-------GSCDIL--HFS-VGSPDQLMVH GCN2_Scer EAIVFSKTIKAKLPNNSMFKFKAVVNPKPIK-------LTSDIF--SFS----------- Y81G3A.3_Cele -----------------GR-RIV------------------------------------- DDB0216407_Ddis -----SI------------------------DHSINNNNNNNNNAFNNF-NN-N-NNN-- IfkB_Ddis ------------------------------------------------------------ 11434_Tthe --------------------------------------GNSNY--YNNNIHNMQNQLMID 18670_Tthe ------------------------------------------------------------ 21870_Tthe ----------------------------------------------IQNV---------- GCN2_Spur ---------------------------------------HVTVI--KFH-TK-G-DRNVH CC1G_02807_Ccin DVR-----------------------------------FNTVKL--FYP-RQG-P-SPFG AqueK195_Aque -----P-------------------------PPLEDN---------PIV-GR-G-NGNIL AqueK194_Aque -----P-------------------------LPLEDS---------PIV-GR-G-NGNIL AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------------------------------------------------------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam ----------------------------------------SILP--I-Y-LQG-SKGTHQ GCN2_Hsap KGKCIGSD-------------------------------------------EQLGKLVYN Gcn2_Dmel RGCCVGHS-------------------------------------------QR-GCIAYT GCN2_Mmus KGRCVGSD-------------------------------------------EQLGKVVYN GCN2_Scer ---------------------------------------------------KQFLVKPYI Y81G3A.3_Cele ------------------------------------------------------------ DDB0216407_Ddis ------------------------------------------------------------ IfkB_Ddis ------------------------------------------------------------ 11434_Tthe NGSCS--DNKSSSQAQQPLQRKLLNDIGSALVKKKARHNKMYGL---SEESEEELL---- 18670_Tthe -------MKIIIPHSKKIMGQIQIDLFQSRIP------ENLRTI---IRFK---YT---- 21870_Tthe -------QQEGRDHSNSIQSQNQSSNQS--------------NNSERQFNSKEKYILDYY GCN2_Spur KGILLGSN-------------------------------------------PE-GSSVYA CC1G_02807_Ccin FGHR-----------------------------------------------VHGADLLIA AqueK195_Aque RGKLLGDS-------------------------------------------SHGYYSVYC AqueK194_Aque RGKLLGDS-------------------------------------------SHGYYSVYC AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------------------------------------------------------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam RGRI-----------------------------------------------APGMRIVI- GCN2_Hsap ALETA--TGGFVLLYEWVLQWQKKMGP-----FL------TSQEKE-------------- Gcn2_Dmel GIDMH--CGQLLYITEWNIKYSQLEQP-----CIGGGKCHWSSESKCM------------ GCN2_Mmus ALETA--TGSFVLLHEWVLQWQK-MGP-----CL------TSQEKE-------------- GCN2_Scer PPESP--LADFLMSSEMMENFYYLL-----------SEIELDNSYF-------------- Y81G3A.3_Cele VLSNM--PNTQLLISEWTFRFSSNRNP-------------AEGKRK-------------- DDB0216407_Ddis ----------------------------------------N------------------- IfkB_Ddis ------------------------------------------------------------ 11434_Tthe FEQCTFKNPP------------LR------------KKADFKIEFEQDDAKGVYRKIETH 18670_Tthe YT---IEYPF------------T----------------------------PVHFVVEPK 21870_Tthe ENQCDVQDVLIMNLIDLVVKLLNL------------DQNSIKNL-TSALN---------- GCN2_Spur GMDAH--SGDLLTIREWVIKWKQGKGR-----K------PLPDEEE-------------- CC1G_02807_Ccin GL-------QTVYLAEPVVDDLHTTPPLELHIYT------FESSYY-------------- AqueK195_Aque GMEVD--SGSLVCIYEWIIPCKTQ------------KKADTRRSRQAGGAG--------- AqueK194_Aque GMEVD--TGSLVCVYEWIIPCKTQ------------KKADTRRSRQA-GAG--------- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------------------------------------------------------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam -------------------DVV--KTNLELVKAL------VESSYV-------------- GCN2_Hsap -------KIDKC-----------------------KK----------------------- Gcn2_Dmel -------GSHRV-----------------------DE----------------------- GCN2_Mmus -------KIDKC-----------------------KR----------------------- GCN2_Scer -------NTSNG-----------------------KK----------------------- Y81G3A.3_Cele -------DFAPF-----------------------LQ----------------------- DDB0216407_Ddis ----------NT----------------------NNS----------------------- IfkB_Ddis ------------------------------------------------------------ 11434_Tthe QVITDYVQTKEIHK---------------------------------------------- 18670_Tthe QNIPDRIDATKFRSQLIEDIKKVAKKQQEKMEESVFNICSMILDFVKEFDEEWIQQQQAK 21870_Tthe --------------------------NYPNL--FQDD----------------------- GCN2_Spur -------DAEAC-----------------------LK----------------------- CC1G_02807_Ccin -------STSQG-----------------------RK----------------------- AqueK195_Aque -------SVGRS----------------------EGN----------------------- AqueK194_Aque -------SVGRS----------------------EGN----------------------- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------------------------------------------------------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam -------NETRT------------------------------------------------ GCN2_Hsap -QIQ--GTETE---------------------------FNSLV--KL--SH----P---- Gcn2_Dmel -VMA--SIEKQ---------------------------VSSLS--QL--QH----K---- GCN2_Mmus -QIQ--GAETE---------------------------FSSLV--KL--SH----P---- GCN2_Scer -EIA--NLEKE---------------------------LETVL--KA--KH----D---- Y81G3A.3_Cele -KLD--AVYNE---------------------------IQKLC--EIKGLD----Q---- DDB0216407_Ddis -NVS--SIDNK---------------------------TIDKQ--QTMI------L---- IfkB_Ddis ------------------------------------------------------------ 11434_Tthe -EIE--EIKQT---------------------------FSSQF--QI--KE----N---- 18670_Tthe GQQQQLQMYKN---------------------------PSTIL--ED--QD----E---- 21870_Tthe -MTK--VIRQQ---------------------------YNYVF--STITKNTLKAF---- GCN2_Spur -QCA--SVEQE---------------------------LLSLL--RL--EH----A---- CC1G_02807_Ccin -KLK--QVEQE---------------------------IKDLT--VT--RH----D---- AqueK195_Aque -LVA--SIRQE---------------------------YDSFS--ERFINH----S---- AqueK194_Aque -LVA--SIRQE---------------------------YDSFS--ERFISH----S---- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------------------------------------------------------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam -FVA--KSNQTDIAGYTGSRISLPASGGGLKLGEEVPLADSFFEPIF--SH----QEKIQ GCN2_Hsap ----------N--V--VRYLAM---NLKEQ----DDSIVVDILVEH-------------- Gcn2_Dmel ----------N--L--VSYECV---LCIK---R-KEGLLVYLVQDF-------------- GCN2_Mmus ----------N--I--VRYFAM---NSREE----EDSIVIDILAEH-------------- GCN2_Scer ----------N--V--NRLFGYTVERMGRN-NA-TFVWKIRLLTEY-------------- Y81G3A.3_Cele ----------N--L--VEYAFV---HLQKISVS-PDQILIQLNVAQ-------------- DDB0216407_Ddis ----------H--L--LRLL-----------------------CQ--------------- IfkB_Ddis ------------------------------------------------------------ 11434_Tthe ----------Q--N--VNG----------------------------------------- 18670_Tthe ----------NADT--VHT----------------------------------------- 21870_Tthe ----------HKQA--VKN---------IS----NYSQTVQDLIHC-------------- GCN2_Spur ----------N--I--VHYLAM---NYNK---G-KEDINVQLLMEY-------------- CC1G_02807_Ccin ----------H--L--LATLAV---KLKLPH-S-SDPAQLIVLTEQ-------------- AqueK195_Aque ----------S--I--VKYLLM---RHNLT----EHGILVEVTMEY-------------- AqueK194_Aque ----------S--I--VKYLLM---RHNLT----EHGILVEVGMEY-------------- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------------------------------------------------------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam AQGTAMFTLAS--LISIYFL-V---MLSLQR-NIRGGIATNRFYDFLALVTQEECDIRPW GCN2_Hsap ------------ISGVSLAAHLSHSG---PIPVHQLRRYTAQLLSGLDYLHSNSVVHKVL Gcn2_Dmel ------------LLGTSVFSI-SSSL---GWCMDGARMVARGVLDALVFLHNKGVSHSHL GCN2_Mmus ------------VSGISLATHLSHSG---PVPAHQLRKYTAQLLAGLDYLHSNSVVHKVL GCN2_Scer ------------CNYYPLGDLIQSVG---FVNLATARIWMIRLLEGLEAIHKLGIVHKCI Y81G3A.3_Cele ------------KIFSS-EENMQDTYELIVQKSNLLRLLAAQAICGLRYLHEASMTHKHL DDB0216407_Ddis -------------------------NDS-NITNDHIKTLGEQLVQ-------MGI-FNRN IfkB_Ddis ------------------------------------------------------------ 11434_Tthe ------------------------------------------------------------ 18670_Tthe ------------------------------------------------------------ 21870_Tthe ------------ISGN-----------------------QDRQESLLNRVQQNLVLTKQQ GCN2_Spur ------------VGGGNLSQKLENSS---LTSFDLLREYAIDLLSGLQYLHSHAVVHKQL CC1G_02807_Ccin ------------TPHVTLHDVLVDCH---SLREDRATQYLTQILQALNALHNKNLVHRGM AqueK195_Aque ------------ITGGSLNSLLQGSSSS-PITGKSLQLYSKQLLEAVAYLHSQGIVHNDI AqueK194_Aque ------------ITGGSLNSLLQGSSSS-PITGKSLQLYSKQLLEAVAYLHSQGIVHNDI AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------------------------------------------------------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam LHVYKALRLLPLQPDGAVSAWLSSTA---SVPV-TLRDLREEILQHIEHIYGLGVTNTS- GCN2_Hsap SASN---VLVD---AEG---TVK----ITD-----YSISKR-----LADICKEDV--F-- Gcn2_Dmel LDTT---VFMD---NTG---NVR----VSD-----FSLVPN-----LLELLSGAG----- GCN2_Mmus SASS---VLVD---AEG---TVK----ITD-----YSISKR-----LADICKEDV--F-- GCN2_Scer NLET---VILVKDA-DFGSTIPKLVHSTYG-----YTVLNM-----LSRYPNKNGSSV-- Y81G3A.3_Cele TLGS---VWTR---NSTGDCVFR----FSD-----FGSMGP-----LLDLVKMFG----- DDB0216407_Ddis HLSL---LNMH---NSN---DNQ----IYQHIFQDY-FLKQFNDISLSDLKNNVD----- IfkB_Ddis ------------------------------------------------------------ 11434_Tthe -------------------------------------FKMS-----LVKQNLQ------- 18670_Tthe -------------------------------------LPQN-----VKQSDMS------- 21870_Tthe -SSYS-Q----CS--CQG---QK----INN-----SQIKKS-----QSKNNISSN--Y-- GCN2_Spur RASQ---VYVD---CDG---RLR----VAN-----YSMCKR-----LNELAQAAN----- CC1G_02807_Ccin DVRCLGLVSSRTNPGQK---VIK----VGK-----AVFHTH-----LLDLHRSNS--FGP AqueK195_Aque RPSL---VFID---PVQ---GVK----LAG-----HTIIKR-----LSDLTGKVN----- AqueK194_Aque RPSL---VFID---PVQ---GVK----LAG-----HTIIKR-----LSDLTGKVN----- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------------------------ATFKRI-FKQTVD-------KDNVS----- PEKa_Smoe ------------------------------ATFKRI-FKQTVD-------KDNVS----- GK065_Glam ---SEF------------------------------------------------------ GCN2_Hsap ------------EQT-RVRFSDNA-LPYKTGKKGDVWRLGLLLLSLSQGQ---ECGEY-- Gcn2_Dmel ----------------------------QSSSCGDLPALGALVESLMPT----------- GCN2_Mmus ------------EQA-RVRFSDSA-LPYKTGKKGDVWRLGLLLLSLSQGQ---ECGEY-- GCN2_Scer ---------ELSPSTWIAPEL-LKFNNAKPQRLTDIWQLGVLFIQIISGS---DIVMNFE Y81G3A.3_Cele ---------DICSGKYVARDEDKEK--EYDRRRKDLFQLGTLLDGLILAT---RGSTYSR DDB0216407_Ddis ------------SAA--------------------------------------------- IfkB_Ddis ------------------------------------------------------------ 11434_Tthe ---------------------V------IPMLEKM--------KSQSISEINNLNDSA-- 18670_Tthe ---------------------C------I---DNS--------MSKNKSSLDQLQSYA-- 21870_Tthe -------------EIVMNGFSE------INNIKNN--------LSASSGSAGGNQTSS-- GCN2_Spur ------------EGKQTVRFSDDKTYGGRGGKKGDVLDLGLLLLGLLLGT---SDVQY-- CC1G_02807_Ccin HIPPVADEPQISDGWLSREMKDSA-L--LYTKRRDIHNVGIILLQMLMGL---DVTER-- AqueK195_Aque ------------EEAWPRGF-----FTKLGGKKTDILKLGMVIFCMSVGR---VTVSY-- AqueK194_Aque ------------EEAWPRGF-----FTKLGGKKTDILKLGMVIFCMSVGR---VTVSY-- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------E----------------------------------------------- PEKa_Smoe ------------E----------------------------------------------- GK065_Glam -----------------------I-R--LVQQRPETIEQQM------------------- GCN2_Hsap -P-VTIP--SDLP---------ADFQDFL--KKCVCLDDKE------------------- Gcn2_Dmel ----------N-S---------YEMRDFV--DKCNS---DR------------------- GCN2_Mmus -P-VTIP--SDLP---------ADFQDFL--KKCVCLDDKE------------------- GCN2_Scer TP-QEFLDSTSMD---------ETLYDLL--SKMLNNDPKK------------------- Y81G3A.3_Cele VP-TPVEGNQNTG----T----NLLGNFI--AKCQE------------------------ DDB0216407_Ddis ----NNS--GHFL---------NKFWDTL--NKTNENS---------------------- IfkB_Ddis ------------------------------------------------------------ 11434_Tthe -QRGQFN--S------------YEKE------QQ-------------------------- 18670_Tthe -IK-KSF--V------------YEYQ-----DKL-------------------------- 21870_Tthe -P-KDSN--Q------------QEMQ-----KKK-------------------------- GCN2_Spur -P-CEVP--QDLP---------LDLQDFL--NRCIDIDERS------------------- CC1G_02807_Ccin -Y-SDVQ--EAIHSSAISPVLARQATNMLTP--TKKNNISC------------------- AqueK195_Aque -P-PDVP--EHFS---------EDFKDFL--NKCLNNNEYQ------------------- AqueK194_Aque -P-PDVP--EHFS---------EDFKDFL--NKCLNNNEYQ------------------- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------------------------------------------------------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam ------------------IIEHYQNTDCLSFAKTSSDNVTVGIRQPSTIEAQLGLESRMM GCN2_Hsap ---RWSPQQLLKHSFINPQ------PKMPLV-EQSPEDSEGQ-D-----YV--------- Gcn2_Dmel ---TLSASELLEHPFLRFYVDNGQQQVMPLPQQQHPNTV--Q-R-------TGS------ GCN2_Mmus ---RWSPQQLLKHSFINPQ------PKLPLV-EQSPEDSGGQ-D-----YI--------- GCN2_Scer ---RLGTLELLPMKFLRTNIDSTIN-RFNLV-SESVNSNSLELTPGDTITVRGNGGRTLS Y81G3A.3_Cele ---AKNIDQLVEDPFLKEE-------------------C--Q-S-------ESE------ DDB0216407_Ddis ---GLKK--------------------SPSTFEYSG--EGGG-G-----GV--------- IfkB_Ddis ------------------------------------------------------------ 11434_Tthe ------LALYMKSPFEVET------RISPL-YE---Q----------------------- 18670_Tthe ------LGDFR-----EEV------NLSRQSLSSTDQDQ----------Q---------- 21870_Tthe --------LRLNNSDNGEK------RLSD-SADSLQSDH----------QI--------- GCN2_Spur ---RANVQSLLDHPFIKPTISDNP--DPPS-VSSSESRA--Q-E-------ESS------ CC1G_02807_Ccin ---MTLLSELAEDS-LK-----------ASL-QQTPMTSRSI-P-----IMNSSGGP--- AqueK195_Aque ---RYPAHELLVHPFITPP------TFIPGSIDHTHRTEAGF-G-----PLRDK------ AqueK194_Aque ---RYPAHELLVHPFITPP------TFIPGSIDHTHRTEAGV-G-----LLRDK------ AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ---FWNA--------------------SPDL---LG------------------------ PEKa_Smoe ---FWNA--------------------SPDL---LG------------------------ GK065_Glam AALQSF-YVLLKD----------------------PFD-------------ERTGLI--- GCN2_Hsap ETVIP--SN--RLP---SAAFFSETQRQFSRYFIEFEELQLLGKGAFGAVIKVQNKLDGC Gcn2_Dmel -----------AMP--Y---QIPTLALSQSRLRTEFEVLMYLGKGAFGDVLKVRNILDNR GCN2_Mmus ETVIP--SN--QLP---SAAFFSETQKQFSRYFIEFEELQLLGKGAFGAVIKVQNKLDGC GCN2_Scer QSSIRRRSF--NVG---S-RFSSINPATRSRYASDFEEIAVLGQGAFGQVVKARNALDSR Y81G3A.3_Cele -------------N---IFTPFGGAMSPDGRMLADNVIIRVLGRGGFGDVVLVRNKMDST DDB0216407_Ddis -----------GGG---S-SQKTINPHQQSRYHSDFEEIQLLGRGGFGQVVKVRNKLDGR IfkB_Ddis ----------------------------------------MIGKGGFGVVVKSRNKLDCR 11434_Tthe --------------------SHIKQYLDNGKFNKFFRVIDELGRGGFGRVYKVQSMVEEK 18670_Tthe --------------------EEKVLENLKSAYKTNFEEVEQIGKGGFGQVYKVKNRLDSL 21870_Tthe QTQ----DK--KNN---L-LSFEPANTEKSRYLTDFEEIQVLGQGAFGQVVKVRNKLDGR GCN2_Spur -----------ALD--FPGVPTADINLGVSRLHSEFEFLAFLGKGGFGNVIKVRNKLDGN CC1G_02807_Ccin RTPVP--SMYYGSPEVDYVMHRMRQARQSSRWKDDWEELELLGKGAFGSVVKARNKVDNR AqueK195_Aque -------SA--DSS---L-ADPVSHAGGRSRLEAEFEVLEVLGKGGFGDVIKVRNYLDSR AqueK194_Aque -------SA--DSG---L-ADPVSHVGGRSRLEAEFEVLEVLGKGGFGDVIKVRNYLDSR AqueK193_Aque ------------------ASSSYSAHSESSRFTRDFEEIKLLGKGAFGEVYHVKHNLDKK PEKc_Smoe -------------------ENDGNLAAMNSRYLSDFEELCLLGKGGFGHVVLCKNKLDGR PEKa_Smoe -------------------ENDGNLAAMNSRYLSDFEELCLLGKGGFGHVVLCKNKLDGR GK065_Glam ----------------DPFSINGYLKATKSVYLKDFVELYQLGKGGYGEVVCANRLMENQ :*:*.:* * . :: GCN2_Hsap CYAVKRIPINPAS------------RQFRRIKGEVTLLSRLHHENIVRYYNAWIERHERP Gcn2_Dmel EYAIKRIPLPARSR-----------QLYKKMTREVELLSRLNHENVVRYFNSWIESVDDA GCN2_Mmus CYAVKRIPINPAS------------RHFRRIKGEVTLLSRLHHENIVRYYNAWIERHERP GCN2_Scer YYAIKKIRHTE--------------EKLSTILSEVMLLASLNHQYVVRYYAAWLEEDSMD Y81G3A.3_Cele DYAIKRIPLNAKSD-----------KLNRKIAKEAKFFAKLNHPNMVRYYYAWAEDLIPI DDB0216407_Ddis YYAIKKIKLDSN------------QSLNRRILREVITLSRLHHQHVVRYYQAWIESAESL IfkB_Ddis YYAIKKIKTKGYTDS-------NQEPLTNKLLREVTTLSRLHHQFVVRYYQAWIEKSCDS 11434_Tthe IYAIKKIAVPYDG---------FSNPKEHKYFREVKSIMSLNHINIVRYHTSWWENCDDE 18670_Tthe NYAVKKIKLDIN-----------QKELTKKTLKEVKLLSILQHNHIVRYYQAWLEKPDEK 21870_Tthe YYAIKKIKIRKG-------------QNIEKLMREVTLLSRLHHRHVLRYYQAWLEESNQS GCN2_Spur LYAIKKILLNPKSR-----------ELNKKITREVKLLSRLNHENVVRYYNSWIEVAEEP CC1G_02807_Ccin VYAVKKVRLKAVQ-------------KDDKIMREVNALSRLNHRFIVRYYTTWIETTEAP AqueK195_Aque LYAIKKVRLTGG------------SKMMTKLTREVELLSQMNHENIVRYYNAWIEKYSEP AqueK194_Aque LYAIKKVRLTGG------------SKMMTKLTREVELLSQMNHENIVRYYNAWIEKYSEP AqueK193_Aque EYAMKIIPANK---------------INQKDLREVLALSDFKHSGIVQYYCSFIDDCAKV PEKc_Smoe RYAMKKVKLKDE-------------NPSDKILREVATLSRLQHQHVVRYYQAWFETAAGG PEKa_Smoe RYAMKKVKLKDE-------------NPSDKILREVATLSRLQHQHVVRYYQAWFETAAGG GK065_Glam KYAVKKVVIDRRDFHAKTESVGGFLQYIKSIMNEVRILSRLLHPFIVKYYYSWIETTSDT **:* : *. : : * :::*. :: : GCN2_Hsap AGPGTPPP--D----------SGPLAKDD------------------------------- Gcn2_Dmel DAAEMDKL--L-GGE--------------------------------------------- GCN2_Mmus AVPGTPPP--D----------CTPQAQDS------------------------------- GCN2_Scer ENVFESTD--E----------ESDL----------------------------------- Y81G3A.3_Cele VEETSDDD--S-SLGAVPIPGKEKIGKKG------------------------------- DDB0216407_Ddis SLTNDNSDDDDD-----------D---DD------------------------------- IfkB_Ddis FQSLEEGNEDLSGDL------ETD---ASEDWFMQSSINSRSIISRDSYSGLSTSNSNVG 11434_Tthe MVNQVNEF--L-QT-------NNNL----------------------------------- 18670_Tthe TLQEFENS----EE-------EDEL----------------------------------- 21870_Tthe EEEES-----M----------GSQM----------------------------------- GCN2_Spur PTTDTDES--R-TTG--------------------------------------------- CC1G_02807_Ccin STTVSDDS--S-A-E------SSMI----------------------------------- AqueK195_Aque NHHGNEEE----GEE------FSD------------------------------------ AqueK194_Aque NHHGNEEE----GEE------FSD------------------------------------ AqueK193_Aque AAGWTSY-----H-S------RS------------------------------------- PEKc_Smoe SSGTPYG----------------------------------------------------- PEKa_Smoe SSGTPYG----------------------------------------------------- GK065_Glam VQNATEA-----P-N------SSMI----------------------------------- GCN2_Hsap ----RAARGQPASD----------------------TDGLD-----------------SV Gcn2_Dmel -------WSQSQQD----------------------LSVKP---------------AK-- GCN2_Mmus ----PATCGKTSGD----------------------TEELG-----------------SV GCN2_Scer ------------------------------------------------------------ Y81G3A.3_Cele ----KLKTGKSLEDKE----------------N---KANLGGGDSLMPMNLRGLVKDHSI DDB0216407_Ddis ----EFESGSESEESQ----------------SESESESSE-----------------SE IfkB_Ddis GANNTAGGGDSVSNANSNKSMIVGNNNKKLTLSSSNTSSSS-----------------SL 11434_Tthe ------------------------------------------------------------ 18670_Tthe ------------------------------------------------------------ 21870_Tthe ------------------------------------------------------------ GCN2_Spur -------TGETSPD----------------------TNGVGRGAREVPLAVNSLSLSDNI CC1G_02807_Ccin ------------------------------------------------------------ AqueK195_Aque ------------------------------------------------------------ AqueK194_Aque ------------------------------------------------------------ AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------------------------------------------------------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam ------------------------------------------------------------ GCN2_Hsap EAAAPPPIL------SSSVEWSTS------------------------------------ Gcn2_Dmel ------------------------------------------------------------ GCN2_Mmus EAAAPPPIL------SSSVEWSTS------------------------------------ GCN2_Scer ---------------SE------------------------------------------- Y81G3A.3_Cele G--------------VDAKEWSTP-------------------------FGKPEGPKCAS DDB0216407_Ddis ES-------------SES------------------------------------------ IfkB_Ddis LSNNKSKILNTSKSTSTN-----TSTSTSTSNTNKNKKISKKKKSKLSPLMKPKNKKNKN 11434_Tthe -Y-------------SDD------------------------------------------ 18670_Tthe -R-------------EDS------------------------------------------ 21870_Tthe -S-------------DQD------------------------------------------ GCN2_Spur EEQALKLSI------RNSLEWSS------------------------------------- CC1G_02807_Ccin ---------------TSS-EVTSI------------------------------------ AqueK195_Aque -S-------------SED------------------------------------------ AqueK194_Aque -S-------------SED------------------------------------------ AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------------------------------------------------------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam ---------------SSG-CTTGT------------------------------------ GCN2_Hsap ----GERSA-SARFPATGPGSSDDE--DDDEDE--HGGV-FSQ-SFLPA-SDSESD-I-- Gcn2_Dmel -------------SPQLGPTLEEDE--D-EED---SSSS-MWN-GYIPNMEDSDSDGI-- GCN2_Mmus ----AERST-STRFPVTGQDSSSDE--E-DEDE--RDGV-FSQ-SFLPA-SDSDSD-I-- GCN2_Scer -------------------SSSDFE--ENDLLD--QSS-IFKN-RTNHDLDNSNWD-F-- Y81G3A.3_Cele RMRQSKRSTPSGGLKHLSECSSDDE--D-DDD---SSEI-DWD-AESEEVEDEESDDSDE DDB0216407_Ddis -----EES------------SESSE---SEES-----------------EESEYSDDS-- IfkB_Ddis N----GES------------EQSSS---DSENG--ENGM---KSRIIENASDSYSDDD-N 11434_Tthe ------NS------------PSVSEAYQKNKSDYNRSYA-LS-K---QTNQTQ-SYVL-S 18670_Tthe ------KE------------EECSSENDSAPSKASKESS-MC-FEFIESSEES-SLPF-E 21870_Tthe -----DDN------------GELSDD------RYRYRSN-----NFSS-----------R GCN2_Spur -------------SGNIGLIGDSDD--S-SSD---DEGV-FGR-SFLPRSDDSSSDGI-- CC1G_02807_Ccin ----PDDDS-ERHLPINGGFDLGDL--DD-LDD--ELGS---Q-SS-------FPS-I-- AqueK195_Aque -----EDT------------TEEEE--EEEEER--EEGLSFIEFKLDESTTLNSSDQI-R AqueK194_Aque -----EDT------------TEEEE---EEEER--EEGLSFIEFKLDESTRLDSSDQI-R AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe -----EES------------EISSS---WVDT-----------------P---------- PEKa_Smoe -----EES------------EISSS---WVDT-----------------A---------- GK065_Glam ----GDDSL-E---------------------G--SLG---------------AV----- GCN2_Hsap ----------------------IF-DNEDENS--K------------------------- Gcn2_Dmel ----------------------EF-VDSNG-K--V------------------------- GCN2_Mmus ----------------------IF-DNEDENS--K------------------------- GCN2_Scer ISG-------------SGYPDIVF-ENSSRDD---------------------------- Y81G3A.3_Cele EDEDDGERLVQLNTETSTGADSVF-ERSTADE--D----------------------VV- DDB0216407_Ddis EFE-------------SEENND------FDQS--FSEVFLFQNGNKR-SLEF----DLTD IfkB_Ddis NNN-------------NDSNNNYHSDN-ESDS--FSGSISMSDGNGS-GYEATDDEDIIN 11434_Tthe YNN-------------DNLSCIEW-EQSE------N------------------------ 18670_Tthe FEN-------------YSDNGIVF-EDSDGDEEQKQ------------------------ 21870_Tthe YQD-------------NN--SSYY--D--LS--SL------------------------- GCN2_Spur ----------------------DF-EGSDRGE--E------------------------- CC1G_02807_Ccin ----------------------HF-EGSKSPA--N------------------------- AqueK195_Aque DDS-------------YSFSSDVFTDTEDRDV--FKGKVDTPGTNVATLLEA--DLMVTT AqueK194_Aque DDS-------------YSFSSDVFTDTEDRDV--FKGKVDTPGTNVATLLEA--DLMVTT AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------------------------------------------------------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam ------------------------------TR--A------------------------- GCN2_Hsap -----------------------------------------------------------S Gcn2_Dmel ------------------------------------------------------------ GCN2_Mmus -----------------------------------------------------------S GCN2_Scer ---------------------------------------------ENEDLDHDTSSTSSS Y81G3A.3_Cele ----F----------------------------------T----AES------------E DDB0216407_Ddis DSYSFLHSDCGFLLEVFDLNNKIGGNNTRSMGSSNQHLQQQQQQNQSQQQKKQPQQNQ-S IfkB_Ddis NSGSFD---------------------------------D----NEND-------DDD-E 11434_Tthe ---------------------------------------------ENQN----------P 18670_Tthe ---------------------------------------------KNQN----------S 21870_Tthe ------------------------------------------------------------ GCN2_Spur -----------------------------------------------------------S CC1G_02807_Ccin -----------------------------------------------------------S AqueK195_Aque PRRGFIHS---------------------------------------------------- AqueK194_Aque PRRGFIHS---------------------------------------------------- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------------------------------------------------------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam -----------------------------------------------------------L GCN2_Hsap --QNQ--------D----------------ED----CNEK--------------NGCHE- Gcn2_Dmel ----------AVYD----D-----------EE---QED----------------STR--- GCN2_Mmus --QNQ--------D----------------ED----CNQK--------------DGSHE- GCN2_Scer --ESQD-------DT--DK-----------ES---KSIQN--------------VPRRRN Y81G3A.3_Cele --DLNA----KRRES--IE-----------LM---EINTT--------------TTSKSK DDB0216407_Ddis --QQQK----KLKNS--NSKSKSKSKSK-SKSKS-KSNSK--------------KSISSS IfkB_Ddis --EDDD----DEYDE--EDDDY-ETFDFQDKSRVVSNNSK--------------LSTSSS 11434_Tthe NISNNDGIKKKLDDS--QT-----------IN---EYREQ--------------NKSHKT 18670_Tthe STANNKQETHKRKESQIQD-----------ID-ETDFFTK--------------EDKKKH 21870_Tthe ------------RNS--QD-----------S----SVREQ--------------SGKNQE GCN2_Spur --DISL----SISNR--VK-----------ES---KGNRG--------------KSKEED CC1G_02807_Ccin --DSSG-------D----------------DS---LFDSM--------------SPTNKN AqueK195_Aque -------------------ESS-DSVVFQDTSLMAPPGGEGEEGSTAAAGGGGGAGGGRA AqueK194_Aque -------------------ESS-DSVVFQDTSLMAPPGGEGEEGSTATG---GGGAGGRA AqueK193_Aque ------------------------------DT---TFSS--------------------- PEKc_Smoe ---------------------------------------------------------GSS PEKa_Smoe ---------------------------------------------------------GSS GK065_Glam --DSPS------------------------ST---PFSTP--------------K---PT GCN2_Hsap -SEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQ-------------GL-------YRDT-- Gcn2_Dmel -GKTNSPKPLMQVMYIQMEFCEKCTLRTAIDD-------------NL-------FNDT-- GCN2_Mmus -IEPSVTAEAVHYLYIQMEYCEKSTLRDTIDQ-------------GL-------FRDT-- GCN2_Scer FVKPMTAVKKKSTLFIQMEYCENRTLYDLIHS-------------ENL------NQQR-- Y81G3A.3_Cele LAIDVVPVRKPRILCIQMEYCDRATLRQYIDE-------------NHC------FNAP-- DDB0216407_Ddis KLKNIKKSTSIPYLYIQMEYCQK-ILRNLTET-------------GM-------NLED-- IfkB_Ddis ---RKKPPKETHTLYIQMEYCSKKTLKTLIDN-------------VG-------GIAE-- 11434_Tthe -FNFTKEPSQLLTLYIQLEYCSGKTLRNYLDE-------------QTH------GLDS-- 18670_Tthe --HKKKKSKDFRLLHIQMEFCGGSTLREMIDN-------------HFFCAEKEKRISS-- 21870_Tthe NQKYPVTNFKLMILFIQLEYCPS-TLSHQIKE-------------LKF------QQDT-- GCN2_Spur ISEDNPVFSPVQYLYIQMEFCEKSTLRTAIDA-------------GM-------YEDK-- CC1G_02807_Ccin -LTFPSNFGPSRTLYIQMEFVERQTLRERVDE-------------GI---------SE-- AqueK195_Aque ---KQKQTGQSQYLYIQMEYCSNQTLKVLIDS-------------GQ-------LVKSPG AqueK194_Aque ---KQKQTGQSQYLYIQMEYCSNQTLKVLIDS-------------GQ-------LIKSSG AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ---SNDVNTVSTFLYIQMEYCPR-TLREVFDT-------------RS-------VLDK-- PEKa_Smoe ---SNDVNTVSTFLYIQMEYCPR-TLREVFDT-------------RS-------VLDK-- GK065_Glam -RSTERREIEKVIVFVQMEYCSHGCLSGFIQQCSDGAALCPPLAQGL--------TLT-- GCN2_Hsap -VRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDD-----HVKIGDFGLATDHLAF Gcn2_Dmel -DRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHD-----QIKIGDFGLATTSFLA GCN2_Mmus -SRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDD-----HVKIGDFGLATDHLAF GCN2_Scer -DEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESR-----NVKIGDFGLAKNVHRS Y81G3A.3_Cele -TEVWRIFSEVLCGLKYMHDMAMIHRDIKPLNIFLTSQN-----GVKIGDFGLATLEAMS DDB0216407_Ddis -DDIWKLFRQIVEGMAYVHGQGIIHRDLKPSNIFFDSCG-----DIKIGDFGLAINNKTT IfkB_Ddis -EEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQ-----NVKIGDFGLATSGAPV 11434_Tthe -KEAFQIFSQMLEGVNYLHKNQIIHRDLKPSNILFEN-K-----IAKIADFGLSIQQELG 18670_Tthe -KQKKSLLAQILEALKYLHEKELIHRDLKPQNILLDQSG-----QIKLVDFGLATTLKKE 21870_Tthe -VQIWQYFRQILEGLNYIHSQNTIHRDLKPENIFIDCLG-----DIKIGDFGLAKSQKQN GCN2_Spur -RRLWTHFREIIEGLAHIHLQGMIHRDLKPVNIFLDSND-----FVKIGDFGLATSEQMA CC1G_02807_Ccin -EEGWRLFHQIVDALVHMANLGIIHRDIKLTNIFIALAKIMGLTLFPVGDFGLATSSLAA AqueK195_Aque FELGWQLFREITEGLAHIHSQGMIHRDLKPVNIFLNSSG-----HCKIGDFGLATTFSKY AqueK194_Aque FELGWQLFREITEGLAHIHSQGMIHRDLKPVNIFLNSSG-----HCKIGDFGLATTFSKY AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe -ELTWGIFRQIVEGLSHIHGQGIIHRDLTPSNIFFDTRN-----DVKIGDFGLGVCAAKF PEKa_Smoe -ELTWGIFRQIVEGLSHIHGQGIIHRDLTPSNIFFDTRN-----DVKIGDFGLGVCAAKF GK065_Glam -ELLWRMTAQLASAVAYIHSKDIVHYDIKPANVFLDESY-----NIKLGDFGTSYTCKGP GCN2_Hsap SADS---KQD-----D-------------------------------------------- Gcn2_Dmel L--Q---AHD-----A-------------------------------------------- GCN2_Mmus TAEG---KQD-----D-------------------------------------------- GCN2_Scer LDIL---KLD-----S-------------------------------------------- Y81G3A.3_Cele SKGK---IVG-----GAAEKS---T----------------------------------- DDB0216407_Ddis STLSPTTNIN-----SSTSSAGSLTTSSNSVQSVINTKQQQQQQQPQNYWEDEVEGQQQQ IfkB_Ddis SKS---DDLN-----SSTSNAANNINL-------SS------------------------ 11434_Tthe LI-N---AN--------------------------------------------------- 18670_Tthe RQIE---RKAVLNLKRASSVQ-SNF----------------------------------- 21870_Tthe VF-S---KYQ-YVIEKEEN----------------------------------------- GCN2_Spur GALT---SEV-----SCHNR---------------------------------------- CC1G_02807_Ccin VDPS-----D-----V-------------------------------------------- AqueK195_Aque HTGL---SRQ-------------------------------------------------- AqueK194_Aque HTGL---SRQ-------------------------------------------------- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ADLQ---NPD-----QD------------------------------------------- PEKa_Smoe ADLQ---NPD-----QD------------------------------------------- GK065_Glam SDDQ-----D-----L-------------------------------------------- GCN2_Hsap ------QT--------G-DLIKSDPSGHLTGMVGTALYVSPEVQGS-------------- Gcn2_Dmel ------AP-------APVNQITSAEDGTGTGKVGTTLYVAPELTGNA------------- GCN2_Mmus ------QA--------GDGVIKSDPSGHLTGMVGTALYVSPEVQGS-------------- GCN2_Scer ------QN-------LP------GSSDNLTSAIGTAMYVATEVLDG-------------- Y81G3A.3_Cele -SI-EAML-------SPNGVKSKGSDVHQTRDIGTQLYMAPELFVDE------------L DDB0216407_Ddis QQQ-QQQQ-------QQQQQQQQQQQQQHTARVGTLFYTSPEQEAGT------------- IfkB_Ddis STN-STAQ-------QTPMWDLNDENLSMTGGVGTPFYCCPEILEKN------------- 11434_Tthe ----QELP-------SQKNIDGQDISVAHTGNVGTPFYMPPEQQDK-------------- 18670_Tthe -YNASSLPGEIDYKDKKSENSNNYFPSEITRGVGTGVYRAPEQEN--------------- 21870_Tthe -----ELFNQLV--NKQYLTEKELEAIDQTLNVGTYFYRPPAS----------------- GCN2_Spur ------LT-------DSSHSGEATPGNHLTGKVGTALYVAPELCKA-------------- CC1G_02807_Ccin ------QH--------K--PVTY--DPEMTLEVGTRLYIAPEVQWTG------------R AqueK195_Aque ------QS-------IPSN--TS-ILAGDTGLVGTMLYLAPELLKS-------------- AqueK194_Aque ------QS-------IPSN--TS-ILAGDTGLVGTMLYLAPELLKS-------------- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------HR-------VPVKFEANVKSLEGTGQVGTYFYRAPEIEQA-------------- PEKa_Smoe ------HR-------VPVKFEANVKSLEGTGQVGTYFYRAPEIEQA-------------- GK065_Glam ----------------------------FASDRSTLSYMAPELSAQHWMQSSLNNAAQSN GCN2_Hsap -TKSAYNQKVDLFSLG--------------------IIFFEMSYHPMVTASERIFVLNQL Gcn2_Dmel -SKSVYNQKVDMYTLG--------------------IILFEMCQPPFDTSMERAQTIMAL GCN2_Mmus -TKSAYNQKVDLFSLG--------------------IIFFEMSYHPMVTASERIFVLNQL GCN2_Scer --TGHYNEKIDMYSLG--------------------IIFFEMIYP-FSTGMERVNILKKL Y81G3A.3_Cele VHKAPYTSKIDIYSAG--------------------VVLFEMFYRPLPPSMDRVSTLNNL DDB0216407_Ddis NGDSAYDDKVDMYSLG--------------------IVFFEMWYV-FSTGHERVIVLRNL IfkB_Ddis --TKHYGTKVDMYSLG--------------------IIFFEMCFQ-FQTQMERSNILRDL 11434_Tthe --SGKYNEKIDVYSLG--------------------IILLEIIHK-MDTYHEKLEIVKKL 18670_Tthe --TSSYCTKADMFSLGILNQAKQYFNNLIFKINKIGVIIFEMWYP-LPTFMEKYQTLKEI 21870_Tthe --QSMHEERADIYALG--------------------IIFFEMWFY-FQSKYQRFKVLTIL GCN2_Spur -RIGHYNQKVDLYSLG--------------------IIFFEMCYRSLSTGMERVKILGQI CC1G_02807_Ccin RAAPKNHNKADMYSLG--------------------IVFFEMNYR-FTTGSERIVVLEDL AqueK195_Aque --VVKYTQKVDMYSLG--------------------IILYEMSHPPPATVMERVKILTDV AqueK194_Aque --VVKYTQKVDMYSLG--------------------IILYEMSHPPPATVMERVKILTDV AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe --WPHIDEKVDMYSLG--------------------VILFELWHP-FSTGMERYVTLNEL PEKa_Smoe --WPHIDEKVDMYSLG--------------------VILFELWHP-FSTGMERYVTLNEL GK065_Glam LPVTALRKQADMYSLG--------------------ITLLELWFL--PTASDNLSNLRVL GCN2_Hsap RDPTSPKFPEDFD-DGEHA----KQKSVISWLLNHDPAKRPTATELLKSE--LLPPPQME Gcn2_Dmel RNVS-INIPDAMLKDPKYE----KTVKMLQWLLNHDPAQRPTAEELLISD--LVPPAQLE GCN2_Mmus RDPTSPKFPDDFD-DGEHT----KQKSVISWLLNHDPAKRPTAMELLKSE--LLPPPQME GCN2_Scer RSVS-IEFPPDFD-DNKMK----VEKKIIRLLIDHDPNKRPGARTLLNSG--WLPV-KHQ Y81G3A.3_Cele RDD--IKIPSDFG-AGLAAPMAGLARRTVEKMLQRNPDERPTADDLLNDE--DLPMHTKE DDB0216407_Ddis REKF--EFPSDFE-RN-HS----RQATLIRMLIDKDPAKRPSAQQLLQSE--LMPP-KME IfkB_Ddis RDNL--KFPPGFE-ST-KP----DQTQIIRSLLSRDPTQRPSTKQLLESG--LLPS-KME 11434_Tthe KGSQ--ELPKNLQ-KT-QKYA----CELIIQMTSLKPQNRPSIEQILQG---------K- 18670_Tthe REKN--QLPQDFN-LK-VGNDAKEIRDILTKLLDPDPSKRYSAEELLKT---------LE 21870_Tthe RNNN--LFPDQFE-QF-HPKQ----AKLIAWMLNFSSQKCQKVMEIMQSD--LIPP-KIE GCN2_Spur RQES-IQLPEDFD-EVRNT----NENAIVHWLLNHDPKERPTSQELLESK--LLPPPQME CC1G_02807_Ccin RKPG-IFFPTSWE-PH-RT----RQREIITWLLQHDPEKRPSALDLSQSP--LMPP-RVE AqueK195_Aque RKKE-IVFSERFK-TS-KK----MSKQ--------------------------------- AqueK194_Aque RKKE-IVFSERFK-TS-KK----MSKQ--------------------------------- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe KQQN--ILPSNWA-AK-FP----HQAALVHLLVSPHPQDRPSAREVLQSE--LLPP-RME PEKa_Smoe KQQN--ILPSNWA-AK-FP----HQAALVHLLVSPHPQDRPSARDVLQSE--LLPP-RME GK065_Glam VQNK--QLPSEFT-ET-HP----NVSAILYQLCDVHPLKRLTASALIEALSALNLP-VI- GCN2_Hsap ESELH---------------EVLHHTL----TNV-DGKAYRTMMAQIFSQR--------- Gcn2_Dmel ANELQ---------------EMLRHAL----ANP-QSKAYKNLVARCLQQE--------- GCN2_Mmus ESELH---------------EVLHHTL----ANI-DGKAYRTMMSQIFCQH--------- GCN2_Scer DEVIK---------------EAL-KSL----SNP-SSPWQQQVRESLFNQS--------- Y81G3A.3_Cele DATFR---------------NLCEKVI----KKR-DGRMNAWLLDKQFKEE--------- DDB0216407_Ddis DEYIK---------------NSI-RVI----TNP-TNQFYQTMLNSLFSQN--------- IfkB_Ddis DDILK---------------EAI-KTI----ANP-TISLFSYLMEKLFCLS--------- 11434_Tthe ------------------------------------------------------------ 18670_Tthe DEQYL---------------EHL-SQI----TNP-NNADHRKLIEYLFKVQ--------- 21870_Tthe DDYIV---------------DAI-KAL----NNP-SGPVFKQILEALFKGG--------- GCN2_Spur DARLQ---------------DMLHQTV----ANR-QSKGYHYLMTELFAVE--------- CC1G_02807_Ccin DEYFH---------------QALG-LM----AKP-DTPHYQTVLSLLFNQP--------- AqueK195_Aque ---------------------AVEHTL----QNP-NSSQYKRLMEKLFSQE--------- AqueK194_Aque ---------------------AVEHTL----QNP-NSSQYKRLMEKLFSQE--------- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe DEALK---------------DIL-RTI----HSTDNTFVFDQVIAALFDEE--------- PEKa_Smoe DKALK---------------DIL-RTI----HSADNTFVFDQVIAALFDEE--------- GK065_Glam SAVFKNVPYVVTCSPENRLSDILN-LLEHSEDGI-SQEDRHALMNFLIKDSYCAGLSLLS GCN2_Hsap ISPAIDY----TY------------------------------------DS---DILKGN Gcn2_Dmel SDEVLEH----TY------------------------------------HL---GSSRAM GCN2_Mmus ISPAIDY----TY------------------------------------DS---DILKGN GCN2_Scer YSLTNDI----LF------------------------------------DN---SVP--- Y81G3A.3_Cele VPTSLNY----CY------------------------------------DV---DICLE- DDB0216407_Ddis HQHLHSH----IY------------------------------------HHQQSSVTSS- IfkB_Ddis NDEHIMS----RY------------------------------------LYTS------- 11434_Tthe ------------------------------------------------------------ 18670_Tthe NLPSAIY----TV---------------------------------------EPYIKLIR 21870_Tthe HKVNEIS----NI--------------------------------------QHFTSHTGQ GCN2_Spur SRPVADF----TY------------------------------------DI---DMHKG- CC1G_02807_Ccin TKASRGF----LY------------------------------------DK---DLDR-- AqueK195_Aque NSKLFEM----SF------------------------------------FSEHSSLDLD- AqueK194_Aque NSKLFEM----SF------------------------------------FSEHSSLDLD- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe KLA--SK-----T------------------------------------DNEA-NLSIG- PEKa_Smoe KLA--SK-----T------------------------------------DNEA-NLSIG- GK065_Glam LRESRDALAELPSPTSLTRPQDYCKPETKSICKQGVLSAKRRCDVLEVPNK---SAQE-- GCN2_Hsap ----------FSIRTAKMQ-QHVCETIIRIFKRHGAVQLCTPL-LLPRNRQIY------- Gcn2_Dmel KSWNSAIIIDDIVSLNPVI-EFVKAKVVNLFRKHGAIEVDSPL-LSPLSARNST------ GCN2_Mmus ----------FLIRTAKIQ-QLVCETIVRVFKRHGAVQLCTPL-LLPRNRQIY------- GCN2_Scer --------TS-TPFANILR-SQMTEEVVKIFRKHGGIENNAPPRIFPKAP-IY------- Y81G3A.3_Cele --------RAKYNNREVLV-ETLRAEFCKILKIHSFEKLHTHT-LMPVSTALAA------ DDB0216407_Ddis -SYSKSLF-C-SLDLLQVK-QLVDDVIITILKKHNANEMLTPQ-MSIIKEWNEQPNLFNN IfkB_Ddis ---N-PSL---TPMHLICR-EKTFSRLEKIFLNHGSIRIDTPT-LFPKNPTNST------ 11434_Tthe ------------------------------------------------------------ 18670_Tthe -------F-------TQSY-QLIQDRIKSVFEAHGGINLEANP-LVPLTENIYL------ 21870_Tthe -------LE------SQFN-NYFISKIYSFFEHKGVLNYESPL-NVPPPTVQLK------ GCN2_Spur ----------FSLKNSLTQ-QMVYDTVQRIFQKHGAVRINTIM-LLPKTKLYE------- CC1G_02807_Ccin ------------PEYLSLA-DAVQDRLAALFKLHGAVDIEPPL-LMPVVDRE-------- AqueK195_Aque -KVNKSSF---SPTYFLLQ-QFVWNVTESVFNKHCGLCVNVPF-LEPMTESLV------- AqueK194_Aque -KVNKSSF---SPTYFLLQ-QFVWNVTESVFNKHCxxxxxxxx-xxxxxxxxx------- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ---DLDHL---TPKWLTAQ-ELVIGLTKDVLTRHGARKFRSPS-MTVASDVKT------- PEKa_Smoe ---DLDHL---TPKWLTAQ-ELVIGLTKDVFTRHGARKFRSPS-MTVASDVKT------- GK065_Glam ------------PFDVCLETSWIEGFIEHVLLLMGTVPITLPS-TVPYASLRP------- GCN2_Hsap -----------------------------------------------------------E Gcn2_Dmel ------------------------------------A---------------------NA GCN2_Mmus -----------------------------------------------------------E GCN2_Scer -----------------------------------------------------------G Y81G3A.3_Cele ------------------------------------A---------------------SV DDB0216407_Ddis SSSSSSTTTTTSTTNTANNTNSVVINKSTSTSNINKV---------------------SN IfkB_Ddis ------------------------------------H---------------------PG 11434_Tthe ------------------------------------------------------------ 18670_Tthe ------------------------------------NKLYLNTKQSRLQFRVKMYHNIIK 21870_Tthe ------------------------------------DDVNIEI-------------EKNK GCN2_Spur -----------------------------------------------------------H CC1G_02807_Ccin -----------------------------------------------------------D AqueK195_Aque -----------------------------------------------------------G AqueK194_Aque -----------------------------------------------------------x AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe -----------------------------------------------------------S PEKa_Smoe -----------------------------------------------------------S GK065_Glam -----------------------------------------------------------D GCN2_Hsap HNEAALFMDHSGMLVMLPFDLRIPFARYVARN---------------------------- Gcn2_Dmel NANAVHLMTHSGCVVVLPCDLRTQFARHVTMN---------------------------- GCN2_Mmus HNEAALFMDHSGMLVMLPFDLRVPFARYVARN---------------------------- GCN2_Scer TQNVYEVLDKGGTVLQLQYDLTYPMARYLSKN---------------------------- Y81G3A.3_Cele RTKPVEVLDRSGVPVALPMDLRQNFVRFCVRN---------------------------- DDB0216407_Ddis KTGKSILMDDSGQLLELRHDLRVSFKSFIETEF------------LNLGDHYKHHHQQQN IfkB_Ddis AANVAKFLDESGTVVYLPYDLTIPWARHVVIH---------------------------- 11434_Tthe ------------------------------------------------------------ 18670_Tthe RQYKSIMLANTGTLVEFSDNLLTPWIQKVKTRHYIQMKKLEKRDNL-------------- 21870_Tthe FSNNPTLMTKDGNIIYLRQTLRESFKKHLRKVNKIF------------------------ GCN2_Spur SDMCAHFMDHSGGIVTLPYDLRVPFARYIARN---------------------------- CC1G_02807_Ccin EKNHATFIDRMGTLVSLPNNLLVPFARLAAKG---------------------------- AqueK195_Aque MEGTVQLLESTGKIITLPQHHWLSFSRYVLQH---------------------------- AqueK194_Aque xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------------------------- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe NRSAVKVINSSGTMFELRYDTRLLFARWVVLN---------------------------- PEKa_Smoe NRSAVKVINSSGTMFELRYDTRLLFARWVVLN---------------------------- GK065_Glam AQQYASV---SDCNVFLTARLTQQLL---------------------------------- GCN2_Hsap -----------------------------------------NILNLKRYCIERV-FRPRK Gcn2_Dmel -----------------------------------------SVNLIRRYCVDRV-YREER GCN2_Mmus -----------------------------------------NILNLKRYCIERV-FRPRK GCN2_Scer -----------------------------------------PSLISKQYRMQHV-YRPPD Y81G3A.3_Cele -----------------------------------------SVQRMKRFNFGRV-YSQTS DDB0216407_Ddis DVRHDNSSNGNSNNNNSNDRHHDQDKSNTTTRSVDEILELLSKAPIKRYEFGHV-FRKPH IfkB_Ddis -----------------------------------------NIQQAKRYTFSKV-YRRSQ 11434_Tthe ------------------------------------------------------------ 18670_Tthe -------------------------------------LQKELSSMIKRYTFACIQFQDSE 21870_Tthe ----------------------------------------LSNQVFKRYELGQA-FRYQQ GCN2_Spur -----------------------------------------NVTNLKRYSIERV-YRERK CC1G_02807_Ccin -----------------------------------------NSKRIKRYHIANI-YRPNP AqueK195_Aque -----------------------------------------DITYLKRYELFKG-YQLSR AqueK194_Aque -----------------------------------------xxxxxxxxxxxxx-xxxxx AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe -----------------------------------------QSTSWKRYEISHT-YRKGV PEKa_Smoe -----------------------------------------QSTSWKRYEISHT-YRKGV GK065_Glam ------------------------------------------------VNMNNA-YQH-- GCN2_Hsap L--DRFHPKELLECAFDIVTSTTN-------------------SFLPT------AEI--- Gcn2_Dmel V--FNFHPKQSYDCSFDIIAPTTG-------------------SHLVD------AEL--- GCN2_Mmus L--DRFHPKELLECAFDIVTSTTN-------------------SSLPT------AET--- GCN2_Scer HSRSSLEPRKFGEIDFDIISKSSSE------------------SGFYD------AES--- Y81G3A.3_Cele A---NGHPHERWECCVDCIGPQCS-------------------SPSLE------AEL--- DDB0216407_Ddis L--VGKLPKELSQFCFDVFGSS---------------------SLYSD------AET--- IfkB_Ddis ---PGFSPKELYECDFDIIGPSKS-------------------RHISD------AET--- 11434_Tthe ------------------------------------------------------------ 18670_Tthe K--KKFYPVENKRASFDIVYIKDEEYQSQDIS---------SVRQYYE------ANL--- 21870_Tthe N--RE-IKKE-SLVDYDCVNLI---------E---------DLDTYFL------AET--- GCN2_Spur L--FGSHPRELTECAFDIVTNSPG-------------------SLQPD------AEV--- CC1G_02807_Ccin V--A-GHPLIQKAAVFDIITQDVEY------G-----------PIAAG------AEV--- AqueK195_Aque L--PGTHPKERRQFIFDIVSPPTAT------PTVTPTHSARSNKLIYE------CEL--- AqueK194_Aque x--xxxxxxxxxxxxxxxxxxxxxx------xxxxxxxxxxxxxxxxx------xxx--- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ---GYRAPKEYLQGDFDIIGGY---------------------RALAE------AEV--- PEKa_Smoe ---GYRAPKEYLQGDFDIIGGY---------------------RALAE------AEV--- GK065_Glam -------HQSQKQSSSGLLNQESND------G-----------DLYTTTGLGSTSEMLKS GCN2_Hsap IYTIYEII-QEFPAL---------------QERNYSIYLNHTMLLKAI-LLHCGIPEDKL Gcn2_Dmel LSLAFEIT-SELPRL---------------REKNLAIRMNHTNLLRAI-LIFCNVPKAQY GCN2_Mmus IYTIYEII-QEFPAL---------------QERNYSIYLNHTMLLKAI-LLHCGIPEDKL GCN2_Scer LKIIDEIL-TVFPVF---------------EKTNTFFILNHADILESV-FNFTNIDKAQR Y81G3A.3_Cele LLVACEMMIGSLP------------------GMKFTLKIGHAQLIEAQ-IRHLKLSDDVR DDB0216407_Ddis IKVTTEIF-DSLPST----------------QNFYFVRLNHFGIVEYM-WKFIGITDLTL IfkB_Ddis LRIIIEIM-EEFKDELFGNNSGSNSGSGSGGSINYKIRINHYGLLDSI-LSECGVEKRFF 11434_Tthe ------------------------------------------------------------ 18670_Tthe IRVAYEVI-RMFCKD----------------TTKYKIRIGFSGLLDML-ISSISIQEETL 21870_Tthe IMYGVELM-EEIGL------------------QVVKIRINHVNFLRYYMINHLKFNKEQI GCN2_Spur LHLVTEII-NEFPEL---------------QARNYSIRLNHTGLLTAI-LNYCGVPEELH CC1G_02807_Ccin IAVSNDIL-NTFPNL---------------T-GTYNIRVSHSTIVELA-M--ARIPEEHR AqueK195_Aque ISIATEIL-SDLQSL----------------L-SH------------------------- AqueK194_Aque xxxxxxxx-xxxQSL----------------L-SH------------------------- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe IKAAADII-SRVSST-----------------ETCELRLNHLEILDTI-WSWSGVTRQQR PEKa_Smoe IKAAADII-SRVSST-----------------ETCELRLNHLEILDTI-WSWSGVTRQQR GK065_Glam LSITTSAT-QEHAAA---------------E-EGTSARDASS----LL-L--LDLTGSVT GCN2_Hsap S-QVYIIL---YDA-VTEKLTRREVEA--K-----------------------FCNL-S- Gcn2_Dmel G-ALFEGT---MDF-IESRISRFQFHS--SI-------------------TGIMEKS-R- GCN2_Mmus S-QVYVIL---YDA-VTEKLTRREVEA--K-----------------------FCNL-S- GCN2_Scer P-LVSRML---SQVG-FARSF-KEV------------------------KNELKAQL-N- Y81G3A.3_Cele A-ELLDAL---HLISVSDRPHSHKEK----M-------------------DMLTPKI-G- DDB0216407_Ddis KNEISQVV---SQLI-R-QPWF-TV------------------------KKVLLEKF-K- IfkB_Ddis T-VVYQTV---AQLH-W-RLNWAQV------------------------AQS-LKEH-G- 11434_Tthe --------------TYM----------QW------------------------------- 18670_Tthe L-K---IL---ADKSIMEKIQDL-RENDFRQINQLEQIFIDQYGIQKEIFHQIISFF-K- 21870_Tthe R-SLEEFL---ISA-YTNQK---------------------------DIKKRLINDF-Q- GCN2_Spur G-SLYRTL---NKA-RTERLTKVQTQT--RL-------------------CGM-----S- CC1G_02807_Ccin A-AVVEIL---MQS-KSS---TSQKRA--L-----------------------LLKK-G- AqueK195_Aque ------------------------------------------------------------ AqueK194_Aque ------------------------------------------------------------ AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe K-NVAQIL---GTMT-FLRPQSADRKA--RWVFLCE-------------AQFLLQGL-H- PEKa_Smoe K-NVAQIL---GTMT-FLRPQSADRKA--RWV-----------------FVLLLQGL-H- GK065_Glam L-AFQVFLLSSVSE-PST---YYSVQN--T-----------------------RPNACGN GCN2_Hsap -L-SSN--SLCRLYK-FIE-QKG---DLQ-DL-MPTINSLIKQK---------------- Gcn2_Dmel --TSAQ--TLMDMLLANFL-LTGSRSTVD-DSALKSLM---RGK---------------- GCN2_Mmus -L-SSN--SLCRLYK-FIE-QKG---DLQ-DL-TPTINSLIKQK---------------- GCN2_Scer -I-SST--ALNDLEL-FDFR--L---DFE-AA-KKRLYKLMIDSP--------------- Y81G3A.3_Cele -AKAAN--IITKLLI-PVE-DN--FGAFK-EK-VACFRK--KLK---------------- DDB0216407_Ddis -L-PLK--QVERIAN-WVL-VKG---TIP-DV-LKKLDASQNNNPLLSGNGSLGNNNNNN IfkB_Ddis -L-SAS--IVSNIST-YFR-QRG---ELA-QC-VTQLESLLANH---------------- 11434_Tthe ------------------------------------------------------------ 18670_Tthe -I-SSA--NLDTFKE-YLE-ER------------------FIKYQ--------------- 21870_Tthe -I-GDK--DADKLLQ-LLM-LRG---SQQ-GI-KQQILHNLPNCK--------------- GCN2_Spur ------------------------------------------------------------ CC1G_02807_Ccin -L-TRA--VIDELEI-LNE-SED---DID-DV-VYKL---EKIS---------------- AqueK195_Aque ------------------------------------------------------------ AqueK194_Aque ------------------------------------------------------------ AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe -L-SEA--VVDRLQT-AERRFTG---NAD-EV-LARLRGALSNS---------------- PEKa_Smoe -L-SEA--VVDRLQT-AERRFTG---NAD-EV-LARLRGALSNS---------------- GK065_Glam GT-VSSMDTRCYLAR-YLH-PDG---EQRIGA-FRRVLSITTVR---------------- GCN2_Hsap -----TG-IAQLVKYGLK-DLEEVVG--LL--KKL---G---IKL-QVLI--NLGLVYKV Gcn2_Dmel -----GE-AASLARGALR-ELETVVG--LA--YSL---G---VKC-PIHIWAGLPISFDR GCN2_Mmus -----TG-VAQLVKYSLK-DLEDVVG--LL--KKL---G---VKL-QVSI--NLGLVYKV GCN2_Scer --------HLKKIEDSLS-HISKVLS--YL--KPL---E---VAR-NVVI--SPLSNYNS Y81G3A.3_Cele -----VDAARVLVDKAIR-DLEEIVG--TF--KFC---RTEAIEQISIVYD--SQTCYRP DDB0216407_Ddis NNNNNVR-ISSSFTDLLE-DIRQLAV--YF--EKM---S---ISPHKVIF--DLSYCFSE IfkB_Ddis ----------KEATTGIS-DLKILVR--NL--QMI---N---IIP-RFLL--DLSLIHNH 11434_Tthe ------------------------------------------------------------ 18670_Tthe -----------NEINLIHQYLLELTS--YL--------DLFKIPKETLYF--DTCLLPDN 21870_Tthe -----------DLVLKIE-DIEQEFSNQYVNSKMFKGEGYYKV--PEIII--DISLSGKE GCN2_Spur --------------------------------------F---TEQ-QMLIN--VGLVYNI CC1G_02807_Ccin -----SP-LLPLLRPVVA-EIKATLQ--HA--AFA---G---VDR-PMIIH-PLMLGNHH AqueK195_Aque ------------------------------------------------------------ AqueK194_Aque ------------------------------------------------------------ AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ----------PSSIEAIE-ELSRLLS--YL--RNW---R---VEM-LLTV--DVFIVPSD PEKa_Smoe ----------PSSIEAIE-ELSRLLS--YL--RNW---R---VEM-LLTV--DVFIVPSD GK065_Glam -----D--TNLVATSRIR-ALEWVLT--IL--RVL---F---E--------------TIS GCN2_Hsap QQ-HNGIIFQFVAFIK----------------RRQR-AVPEILAAGGRYDLLIPQFRGP- Gcn2_Dmel -ASNGGIVWQMTADL----------------KPNRS-GHPSVLAIGERYDSMLHEFQKQA GCN2_Mmus QQ-HTGIIFQFLAFSK----------------RRQR-VVPEILAAGGRYDLLIPKFRGP- GCN2_Scer AFYKGGIMFHAVYD--------------------DG-SSRNMIAAGGRYDTLISFFARPS Y81G3A.3_Cele RTFGDGLLFQIQVEKP-STI-----------ANNKR-GRRQNVLAGGRYDSALLRERHPR DDB0216407_Ddis NFYSTGIMFQVILK---------------------E-EKHECLAVGGRYDSPLNLNNSNN IfkB_Ddis Q-YYEGLVFQAYIERP-T--------------LSNP-SRTEIIMSGGRYDKLIKSLHPNP 11434_Tthe ------------------------------------------------------------ 18670_Tthe LMYHSGLLFDIINYEELEFIKKRSNKLKEINTHQESNILAKIFIKGGRYDHFFVESQKQK 21870_Tthe LGFKEGFYFSIESCS------------------VKSS--FVSCIVGGTYPIKMRKFQNMC GCN2_Spur -QIFSGVVFQFVASIG---------------RPKKR-PTMDVLAAGGRYDILTL------ CC1G_02807_Ccin QYFKDGILIELTHK---------------------S-KPSNVLAAGGRYDAVIARHSPTL AqueK195_Aque ------------------------------------------------------------ AqueK194_Aque ------------------------------------------------------------ AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe Y-YFNAAYFQIYFPRT-S--------------Y-PG-AQGMLLAVGGRYDVLLEHLAKDY PEKa_Smoe Y-YFNAAYFQIYFPRT-S--------------Y-PG-AQGMLLAVGGRYDLLLEHLAKDY GK065_Glam QHIAYTTVQKRTAE---------------------R-RPKR-LA---------------- GCN2_Hsap Q-ALG-P---------------------------------VP------------------ Gcn2_Dmel Q-KFNPAMPA----------------------------RGVL------------------ GCN2_Mmus Q-TVG-P---------------------------------VP------------------ GCN2_Scer GKKSS-N---------------------------------TR------------------ Y81G3A.3_Cele D-FVY-EI--------------------------------PL------------------ DDB0216407_Ddis S-SSS-SSSSSSNNNNSYNNYNNNNNYNYNYYSNCYLTNFNL------------------ IfkB_Ddis S-LSN-N---------------------------------IV------------------ 11434_Tthe ------------------------------------------------------------ 18670_Tthe -Q----Q---------------------------------AP------------------ 21870_Tthe -E----I---------------------------------SMDNSFNQININTNYFSQQN GCN2_Spur ------------------------------------------------------------ CC1G_02807_Ccin R-QKG-D---------------------------------NL------------------ AqueK195_Aque ------------------------------------------------------------ AqueK194_Aque ------------------------------------------------------------ AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe G-V-H-T---------------------------------PP------------------ PEKa_Smoe G-V-H-T---------------------------------PP------------------ GK065_Glam ------------------------------------------------------------ GCN2_Hsap ----------TAIGVSIAIDKISAAVLN-------------------------------- Gcn2_Dmel ----------SGAGLTFSLDKLVAAVG-V------------------------------- GCN2_Mmus ----------TAVGVSIAIDKIFAAVLN-------------------------------- GCN2_Scer ----------KAVGFNLAWETIFGIAQNYFK----------------------------- Y81G3A.3_Cele ----------CISGFGVAMDVVSQIRDSI------------------------------- DDB0216407_Ddis ----------PITGLSVAMDKVYSRERELYS----------------------------- IfkB_Ddis ----------SGVGVTLACEKIVNSVLNYRQ----------------------------- 11434_Tthe ------------------------------------------------------------ 18670_Tthe ----------EGIGFQVYIDELFNHFFRPIL----------------------------- 21870_Tthe SQQNSTNLNTSQISQNLQVLDISDIASQSSYSSSSSLSKKKVVSKKGDCITRQVSGFTFL GCN2_Spur ------------------------------------------------------------ CC1G_02807_Ccin ----------CAIGIQIALEKILAQLALFQS----------------------------- AqueK195_Aque ------------------------------------------------------------ AqueK194_Aque ------------------------------------------------------------ AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ----------GAVGLTIALQKLIHIAMKDR------------------------------ PEKa_Smoe ----------GAVGLTIALQKLIHIAMKDR------------------------------ GK065_Glam ----------DILNIDITIRFVKGAPLNQEQ----------------------------- GCN2_Hsap ------------------------------------------------------------ Gcn2_Dmel -----E------------------------------------------------------ GCN2_Mmus ------------------------------------------------------------ GCN2_Scer -----LAS-G------------------N----------------------RIKKRNRFL Y81G3A.3_Cele -----N------------------------------------------------------ DDB0216407_Ddis -----QKR-R----------------------------QQLP---------P-----TLS IfkB_Ddis -----HLL-N------------------NCFNTTYTRRNKDPPNSNNNPNNN-----NLN 11434_Tthe ------------------------------------------------------------ 18670_Tthe ---------S-----------------------------------------Q-----YDN 21870_Tthe NDVVNEIIQS-----------------------------------------K-----LDR GCN2_Spur ------------------------------------------------------------ CC1G_02807_Ccin -----NYV-K------------------N----------------------------LIK AqueK195_Aque ------------------------------------------------------------ AqueK194_Aque ------------------------------------------------------------ AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe -----YYG-S-----------------------------------------L-----FIN PEKa_Smoe -----YYG-S-----------------------------------------L-----Y-- GK065_Glam ------FR-LAGERPNIFKVHSLSHIDNI----------------------------VFF GCN2_Hsap MEES-------VTISSCDLLVVSVGQ----M-SMS-RAINLTQKLWT-AGITAEIMYD-- Gcn2_Dmel YAK---------DCRAIDVGICVCGT---RP-PLK-DVTYIMRLLWS-VGIRCGIVEA-- GCN2_Mmus MEEP-------VTVSSCDLLVVSVGQ----M-SMS-RAINLTQKLWT-AGITAEIMYD-- GCN2_Scer KDTAV-----DWKPSRCDVLISSFSN----S-LLDTIGVTILNTLWK-QNIKADMLRD-- Y81G3A.3_Cele KSANI--P--KTPQNHCKVLICSMVQPDGSN-LIT-QKFELAKKLWS-MGIEADVFHI-- DDB0216407_Ddis SESQM--I--AHKFSTPDIFVISLG----PN-LFL-ERIGIVGDLCN-AGFNAETMYI-- IfkB_Ddis NNVSI--F--TKFQSHIEVFVCSLG----SS-LLG-EKLQVASQLWS-AGIKADYSQT-- 11434_Tthe ------------------------------------------------------------ 18670_Tthe QETQIQQQ--LQDYNEIEAIIISI----DED-LKE-EKFILADELWN-HQIKAHVIIE-- 21870_Tthe KISQIPQRFQQLHFFKYECIICSF----GNI-PSI-EKLRFLQCCQI-NKIPAMLYCYKN GCN2_Spur --------------SICDILVVSVGS---ST-LIR-DRIKVVRNLWA-AGFQADVLYD-- CC1G_02807_Ccin EERSF--G--YWSPRRCDVYVVSYHT----G-YLQ-DRLEVVSYLWQ-HNISADIMYE-- AqueK195_Aque ------------SLSKCQGLVCSLNP---DIPLHD-ECLKLVQDLRDLKGLLVDHLYH-- AqueK194_Aque ------------SLSKCQGLVCSLNP---DIPLHD-ECLKLVQDLRDLKGLLVDHLYH-- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe AELSLSCS--KNETEPAEVLVCCRGG---GG-LLK-ERMELADELWS-ANVKADFVCA-- PEKa_Smoe ------------------------------------------------------------ GK065_Glam ----Q--S--LETINSCGIISTAVLL----L-EYL-KTSVFVDRIRV-RYISAE------ GCN2_Hsap WSQS---QEELQEYCRHHEITYVALVSDKEGSH---------VKV-KSFEKERQ--TE-- Gcn2_Dmel ASEL---GDEAQDLAR-LGALHVILVAENG--S---------LRV-RSFERERF--QE-- GCN2_Mmus WSQS---QEELQEYCRHHEITYVALVSDKEGSH---------VKV-KSFEKERQ--TE-- GCN2_Scer CS-S---VDDVVTGAQQDGIDWILLIKQQAYPLTNHKRKYKPLKI-KKLSTNVD--I--- Y81G3A.3_Cele PVDD---LESLTEHRNRASITHILAVYNTLN-E---------VIC-KTETSSETMDVD-- DDB0216407_Ddis ENPT---PEEQQDASITSGALYIITIKEKGAKK--------TIKV-KNIEKRRE------ IfkB_Ddis DYYS---SEDIYSNCRENGIPWVVILREKAFQIG-------KLKV-KQIETRQE------ 11434_Tthe ------------------------------------------------------------ 18670_Tthe PVQA---LFRILETLKKQKIKFLITVKKKKAQNLN-------S----------------- 21870_Tthe EQFA---QEEQQNFADYHDIPLVVFIVEKIYQQKK-------KA---------------- GCN2_Spur DSLS---LEEAQDYCRAMGISHLVILKDSDT-L---------IKV-RSFDKEKVI-VE-- CC1G_02807_Ccin SAISDIEHERLESVCEREGILFTVCPRPRASKQTQ-----SAFKV-KSILKGAE--YD-- AqueK195_Aque -HLE---LEDLQDFCCRRHIPHLIIIDNSLLLRN-------QYKL-RSLDTDKGRVISE- AqueK194_Aque -HLE---LEDLQDFCCRRHIPHLIIIDNSLLVRN-------QYKL-RSLDTDKGRVTSE- AqueK193_Aque ---------------------------------------------------SRS--SS-- PEKc_Smoe IAPS---LTEQYEYAHDNGIKVLVIITESGLSQG-------VVKVVRHLDFKFE------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam ---------EY--SFGANSISFACYVRDLW----N-----VQSRD-SSFAKNNR--TDES GCN2_Hsap ---KRVL-ETELVDHVLQK---LRTKVTDERNGREASD---N------------------ Gcn2_Dmel ---RHLT-RTELVEFIQKM---LRSDGLNGTTVDNFSQLSALGSGD--NRSSGGKERER- GCN2_Mmus ---KRVL-ESDLVDHVMQK---LRTKVGDERNFRDASD---N------------------ GCN2_Scer ----DLD-LDEFL----TL---YQQETGNKSLINDSLTL--------------------G Y81G3A.3_Cele ---SAI---SSVWRGVQAL----DGQ-----SIH----MTPCGGGPISSISTPGDAHHHD DDB0216407_Ddis ---DDVS-RDEIVKFFT------------------------------------------- IfkB_Ddis ---RTVA-RKDLVDFFLKS---RKHNV-DSKNIIQ------------------------N 11434_Tthe ------------------------------------------------------------ 18670_Tthe ------------------------------------------------------------ 21870_Tthe ------------------------------------------------------------ GCN2_Spur ---SSVG-FYNLVEHLQMK---LNKVELTEQ----------------------------- CC1G_02807_Ccin -----LS-RAELVGWLQ-------HQIAEQKR-IDLST---Y------------------ AqueK195_Aque ---RVVSNIQELIEYIIPK---HSIER--------------------------------N AqueK194_Aque ---RIVSNIQELIEYIIPK---HSIER--------------------------------N AqueK193_Aque ---ESAM-ETS------------------------------------------------- PEKc_Smoe ---VDVR-RDDLAKSL-------------------------------------------- PEKa_Smoe ------------------------------------------------------------ GK065_Glam HSKKRTF-VYTTVDGVIDDAPSVEREITDQQR-YSIGT---L------------------ GCN2_Hsap ---LA-----VQNLKG-------------------------------------------- Gcn2_Dmel ----G-----ENG----------------------------------------------- GCN2_Mmus ---LA-----VQTLKG-------------------------------------------- GCN2_Scer DKADEFKRWDENSSA--------------------------------------------- Y81G3A.3_Cele DHHPG-----TPV----------------------------------------------- DDB0216407_Ddis ------------------------------------------------------------ IfkB_Ddis TSSSD-----LSNLIGGINNSGSGGSGGSGGGSSMSSGGGGGGNSNIGGSDHHHHGHHSN 11434_Tthe ------------------------------------------------------------ 18670_Tthe ------------------------------------------------------------ 21870_Tthe ------------------------------------------------------------ GCN2_Spur ----------SPQ----------------------------------------------- CC1G_02807_Ccin ------------GTGA-------------------------------------------- AqueK195_Aque DSTEG-----VPQV---------------------------------------------- AqueK194_Aque DSTEG-----VPQV---------------------------------------------- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------------------------------------------------------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam ------------LTGA-------------------------------------------- GCN2_Hsap -SFSNASGLFEIHG------ATVVPI---------------------------------V Gcn2_Dmel -LSTSASNATIKNN------YSQLPN-LQ------------------------------V GCN2_Mmus -SFSNASGLFEIHG------TTVVPN---------------------------------V GCN2_Scer -GSSQEGDIDDVVA------GSTNN--QK------------------------------V Y81G3A.3_Cele -IASKSSVSTTVATTSIRPISATVAN-LN------------------------------V DDB0216407_Ddis ------------------------------------------------------------ IfkB_Ddis QSTSSSGNSNNSNT------QQTSPIQHHVHFSNTKSIIGSSGIISNATFSGGSSSSSNI 11434_Tthe ------------------------------------------------------------ 18670_Tthe ------------------------------------------------------------ 21870_Tthe ------------------------------------------------------------ GCN2_Spur -VASKSKSIYDANQ------GSSLPQ-YR------------------------------V CC1G_02807_Ccin -AWESTPTTSSSKD------AMATPD---------------------------------V AqueK195_Aque -SASRSSAAATSTD------ASSLPA-VT------------------------------I AqueK194_Aque -SASRSSAAATNTD------TSSLPA-VT------------------------------I AqueK193_Aque ----------L------------------------------------------------- PEKc_Smoe ------------------------------------------------------------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam -FLVTNP-A-EH-N------GDKAPP---------------------------------L GCN2_Hsap S-VL----------A--PEKLSASTRRR--YETQVQTRLQ-----T-------------- Gcn2_Dmel T-FL----------T--HDKPTANYKRR--LENQVAQQMS-----S-------------- GCN2_Mmus I-VL----------A--PEKLSASTRRR--HEIQVQTRLQ-----T-------------- GCN2_Scer I-YV-------PNMA--TRSKKANKREKWVYEDAARNSSN-----M-------------- Y81G3A.3_Cele I-LV-------TSAD--RFHKVMKEKKR--VESQVRNHLT-----E-------------- DDB0216407_Ddis ------------------------------------------------------------ IfkB_Ddis IHFDEPTDSFSTQIV--YQGVEEIKKSK--IETLVQTSLS-----K-------------- 11434_Tthe ------------------------------------------------------------ 18670_Tthe -----------------------NQKTK--YKLQ-------------------------- 21870_Tthe -----------------------FVKT--------------------------------- GCN2_Spur Y-FV----------T--MDKLDNNARKR--YERQIQVRIE-----P-------------- CC1G_02807_Ccin Q-LV----------L--PADVKKQ-RRS--VKHMLNDRAF-----E-------------- AqueK195_Aque -----------TTIG--RQKVAGNIKRR--YDSHILAKLS-----P-------------- AqueK194_Aque -----------TTIG--RQKVAGNIKRR--YDSHILTKLS-----P-------------- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ---------------------------------------A-----D-------------- PEKa_Smoe ------------------------------------------------------------ GK065_Glam Q-PV----------PYDFVSLRFS-ARA--IQETIRQHANRCRIYPITRHCNPVGLVAQI GCN2_Hsap ---SLANL-HQKSSEIEILAVDLP---------KETILQFLSL-EW-DADEQAFN--TTV Gcn2_Dmel ---TLSQF-LKK-ETFVVLVVELP---------PAVVNAIVGAINPREIRKRETE--PEI GCN2_Mmus ---TLANL-HQKSSEIEILAVDLP---------KETILQFLSL-EW-DADEQAFN--TTV GCN2_Scer ---ILHN-L----SNAPIITVDAL---------RDETLEIISI-TSL-AQKEEW-----L Y81G3A.3_Cele ---FVAHF-TSK-TRIEVLVCDIP---------ADVIKKIVSELTK-TSSEAEID--KLF DDB0216407_Ddis ------------------------------------------------------------ IfkB_Ddis ---LFRGFIQSKSSTIRVIVTDLA---------YSVIRDLQISES-H-DNISKFQRVSKE 11434_Tthe ------------------------------------------------------------ 18670_Tthe ---SLAQL-NQK------------------------------------NSEKERE--YEI 21870_Tthe ------------------------------------------------KKEKSKE--MSL GCN2_Spur ---VLEMF-SSR-CIVVVIAV--------------------------------------- CC1G_02807_Ccin ---TSKKV-KASVATMPTVAVDVP---------TSVFDTMC----R-SSSWLSDD--DTW AqueK195_Aque ---LLTQL-PTK-SPIEIIAIDFE---------LEALCQLAVEIN-KSISQSKSDHTSVI AqueK194_Aque ---LLTQL-PTK-SPIEIIAIDFE---------LEALCQLAVEIN-KSISQSKSDHTSVI AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ---LI-----SGP----------------------------------------------- PEKa_Smoe ------------------------------------------------------------ GK065_Glam RASYGDDI-L-LEEKLAILAKTIFIQQTFLLFGFHIIPESN----E-NNNLVQSNCISVI GCN2_Hsap KQLLSR-LP---KQRYLKLVCDEI---YNIKVE-KKVS-VLFLYSYRD---DYYRILF Gcn2_Dmel NYVIER-FSKY--KRYISEINEEV---VDYLSD-AKTPI-VALYSISD---SYYRVII GCN2_Mmus KQLLSR-LP---KQRYLKLVCDEI---YNIKVE-KKVS-VLFLYSYRD---DYYRILF GCN2_Scer RKVFGSGNNST-PRSFATSIYNNL---SKEAHK-GNR-WA-ILYCHKTGKSSVIDLQR Y81G3A.3_Cele DQLIQK-HGKV----DLSPLRRQFHITLNGIST-GSAQVAILFYRQSD---NFYRYLV DDB0216407_Ddis ---------------------------------------------LS-NFNSKSRLNI IfkB_Ddis KLLQLK-NQIFKWKVYPFIVIHS----------------------IKDDKSVIFNSVV 11434_Tthe ----------------------------------------------KK-KALNLDKVY 18670_Tthe NEIIEI-INK---SKY-NPKQNLI---PSSKSN-GS--VFQM-K--FI-MKNGIIQVM 21870_Tthe EDFNSF-LSK---N-----------------------------H--KN-SIKNYLFSK GCN2_Spur -----------------------------------------------S---RIEGITC CC1G_02807_Ccin RSLVAA-FPPG-HSAYASQIRESV---LKHKAD-GHPY-V-LLFAVKE-ERIQLLALT AqueK195_Aque KLLTER-FPSF-GKKYITQVCDA----------------------IQE-RTAKKFVRT AqueK194_Aque KLLTER-FPSF-GKKYITQVCEA----------------------IQE-RTAKKFVRT AqueK193_Aque --------------------------------------------------TCGATFIP PEKc_Smoe ---------------------------------------------L--AVKMLRQSLI PEKa_Smoe ------------------------------------------------INAELSLFVQ GK065_Glam VNKTQFEFRWG-GARRAHHIVDCS---LCPEANMADSI-GRFLSSL-E-EQLASDMHL