CLUSTAL W (1.83) multiple sequence alignment HIPK4_Hsap MST--------------------------------------------------------- HIPK3_Hsap M-------ASQVLVYPPYVYQTQSSAFCSVKK--LKVEPSS-CVF-QERNYPRTYVNGRN HIPK2_Hsap MAPVYEGMASHVQVFSPH--TLQSSAFCSVKK--LKIEPSSNWDMTGYGSHSKVYSQSKN HIPK1_Hsap M-------ASQLQVFSPP--SVSSSAFCSAKK--LKIEPSG-WDVSGQSSNDKYYTHSKT CG17090_Dmel MKTSYPPKASDFVDYAVA--GGGGSGFCSGLGAGLSVRATSFY---G----------DQT HIPK4_Mmus MAT--------------------------------------------------------- HIPK3_Mmus M-------ASQVLVYPPYVYQTQSSAFCSVKK--LKVEPSG-CVF-QERTYPQIHVNGRN HIPK2_Mmus MAPVYEGMASHVQVFSPH--TLQSSAFCSVKK--LKVEPSSNWDMTGYGSHSKVYSQSKN HIPK1_Mmus M-------ASQLQVFSPP--SVSSSAFCSAKK--LKIEPSG-WDVSGQSSNDKYYTHSKT hpk-1_Cele MNFH-------FTLDNDR--K-------RR--RSLSIDIDINF--------------NDK HIPKa_Spur L-------------YPPFIFGSQSSAFCSFKK--GHVDHVA-AAT-H------------S HIPKb_Spur ------------------------------------------------------------ AqueK114_Aque M-------ALEQQRVPLGSN-KWSSC-----------------LW-Q------------- HIPK4_Hsap ------------------------------------------------------------ HIPK3_Hsap FGNSHPPTKGSAFQTKIP---FNRPRGH-NFSL--Q-TSAVVLKNTAGATKVIAAQAQQA HIPK2_Hsap IPLSQPATT--TVSTSLPVPNPSLP-YEQTIVFPGS-TGHIVVT-SASST-----SVTGQ HIPK1_Hsap LPATQGQ----ANSS-HQVANFNIPAYDQGLLLPAPAVEHIVVT-AADSS----GSAATS CG17090_Dmel VTATTDGT---RHQEQ-QQQQL--QQQQQQHILRQP------AT-SASTSSVAA----AA HIPK4_Mmus ------------------------------------------------------------ HIPK3_Mmus FGNSHPSTKGSAFQTKIP---FTKPRGH-SFSL--Q-AGAIVVKDTAGATKVLAAQAQQA HIPK2_Mmus IPPSQPAST--TVSTSLPIPNPSLP-YEQTIIFPGS-TGHIVVT-SASST-----SVTGQ HIPK1_Mmus LPATQGQ----ASSS-HQVANFNLPAYDQGLLLPAPAVEHIVVT-AADSS----GSAATA hpk-1_Cele ----APGT---SSDNE-QRAPK-------------------------------------- HIPKa_Spur CGSPHPTTMTSIHRTHCP---WSQPP-------------------------------RAV HIPKb_Spur ------------------------------------------------------------ AqueK114_Aque -----------------------AERGPAGFILP-------------------------- HIPK4_Hsap ------------------------------------------------------------ HIPK3_Hsap HVQAPQIGAWRNRLHFLEGPQRCGLKRKSEELDNHS----------SAMQ-IVDELSILP HIPK2_Hsap VLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTS----------S-VQ-IIEEH---P HIPK1_Hsap TFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNG----------S-VQ-IIEEH---P CG17090_Dmel T-----------------------SKRKRQTDC-----------DCGCVDSYNSSH---G HIPK4_Mmus ------------------------------------------------------------ HIPK3_Mmus GVEAPRAVVWRNRLHFLEGPQRCGLKRKSEELENHS----------GAMQ-IVDELSILP HIPK2_Mmus VLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTS----------S-VQ-IIEEH---P HIPK1_Mmus TFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVESNG----------S-VQ-IIEEH---P hpk-1_Cele -------------------------RRADEEAVNAVPKNLLTTSSTFARA-VIPAA---P HIPKa_Spur GPHRPQNVIQASTVRLLDTYQKCGLKRKSEELDNHS----------TAAR---------- HIPKb_Spur ------------------------------------------------------------ AqueK114_Aque -----Q------------------------------------------------------ HIPK4_Hsap ------------------------------------------------------------ HIPK3_Hsap AM-LQTN-MGN---------------------------------PVTVVTATTGSKQNCT HIPK2_Hsap PMIQNNA-SGA--------------------------------TVATATTSTATSKNSGS HIPK1_Hsap PLMLQNR-TVV---------------------------------GAAATTTTVTTKSSSS CG17090_Dmel PPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGHANTQPPSKRSSS HIPK4_Mmus ------------------------------------------------------------ HIPK3_Mmus AM-LQTN-MGN---------------------------------PVTVVTATTGSKQNCT HIPK2_Mmus PMIQNNA-SGA--------------------------------TVATATTSTATSKNSGS HIPK1_Mmus PLMLQNR-TVV---------------------------------GAAATTTTVTTKSSSS hpk-1_Cele AISSANNKMAP---------------------------------QSVTATAKTTTNRGKV HIPKa_Spur GM-TDTS-VKN---------------------------------ELTGMITRTGSKKSSS HIPKb_Spur ------------------------------------------------------------ AqueK114_Aque ---------------------------------------------AQVDKGEVDQTKLGG HIPK4_Hsap -------------IQSE-TDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRN HIPK3_Hsap TGEGDYQLVQHEVLCSM-KNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYA HIPK2_Hsap NSEGDYQLVQHEVLCSM-TNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYA HIPK1_Hsap SGEGDYQLVQHEILCSM-TNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYA CG17090_Dmel GADGDYQLVQHEVLYSL-SAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYA HIPK4_Mmus -------------IQSE-TDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRS HIPK3_Mmus SGEGDYQLVQHEVLCSM-KNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYA HIPK2_Mmus NSEGDYQLVQHEVLCSM-TNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYA HIPK1_Mmus SGEGDYQLVQHEILCSM-TNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYA hpk-1_Cele SGEGEYQLIKNEVLCSPYGNQYEVLEFLGKGTFGQVVKAWKKGTSEIVAIKILKKHPSYA HIPKa_Spur GGEGDYQLVQHEVLCSL-TNSYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYA HIPKb_Spur ------------------------------------------------------------ AqueK114_Aque GPSGDYPVSIRELIPSP-TSVYDVLDRLGRGTFGQVVRAWKKNTSEIVAIKILKSTPSYA HIPK4_Hsap RIIKNELKLLHCMRGLDPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLP HIPK3_Hsap RQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLP HIPK2_Hsap RQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLP HIPK1_Hsap RQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLP CG17090_Dmel RQGQIEVSILSRLSQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLP HIPK4_Mmus RIIKNELKLLRCVRGLDPDEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLP HIPK3_Mmus RQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLP HIPK2_Mmus RQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLP HIPK1_Mmus RQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLP hpk-1_Cele RQGQIEVSILSRLSNENSEEFNFVRAFECFNHKSHTCLVFEMLEQNLYDFLKQNKFMPLP HIPKa_Spur RQGQIEVSILARLSAENADDFNLVRAYEYFQHKNHTCLVFELLEKNLYDFLKQSKFRPLP HIPKb_Spur -----------------DDDYNSVAMYNNFPHKFHSCIIIELLERNVYDLLLRDAMSSIP AqueK114_Aque KQGQMEVDVLSKLSRLSPDEGSFVKAYESFQHHGHICIVFELLHINLYDYLKQSRFDPLP :: : : * . : :::*:*. *::: .. : .:* HIPK4_Hsap ARHIRTVTLQVLTALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVR HIPK3_Hsap LKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK-- HIPK2_Hsap LKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSK-- HIPK1_Hsap LKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK-- CG17090_Dmel LKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK-- HIPK4_Mmus ARHIRTVTLQVLRALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVR HIPK3_Mmus LKVIRPVLQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK-- HIPK2_Mmus LKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSK-- HIPK1_Mmus LKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK-- hpk-1_Cele LNAIRPILFQVLTALLKLKSLGLIHADLKPENIMLVDPQQQPYRVKVIDFGSASHRSK-- HIPKa_Spur LKHIRPTLQQVLVALLKLKTLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK-- HIPKb_Spur TPCVLPIYSFLCTVLVTLPRLGQIYYDFDDSRTLQCTPSCQPFQNKFYETGTSVHVK--- AqueK114_Aque LKYIRPIAQQVLCCLEKLASLGLVHADLKPENIMLVDPQRYPFKVKVIDFGSAMSRDK-- : . : * * *. :: *:. .. : *:: *. : *:: . HIPK4_Hsap YVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICE HIPK3_Hsap TVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQ HIPK2_Hsap AVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQ HIPK1_Hsap AVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQ CG17090_Dmel TVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQ HIPK4_Mmus YVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICE HIPK3_Mmus TVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQ HIPK2_Mmus AVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQ HIPK1_Mmus AVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQ hpk-1_Cele AVTNTYLQSRYYRAPEIILGLPFNESIDMWSLGCVIAELFLGWPLYPGSSEYDQIRFIIQ HIPKa_Spur AVCSTYLQSRYYRCVKFLLSITLIEIVCMKSLSCVQTTFYVGWYMYVSFCIHVNVRYIIQ HIPKb_Spur SQYSLCLQ-RSCRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGASEYDQIRYISQ AqueK114_Aque TSPSCYLQSRYYRAPEVILGVNFNEGIDMWSLGCVLAELYLGWPLFPGASEFDQITYICQ . :* * *. :.:*.: : * : : **.** : :.:** :: . . :: :* : HIPK4_Hsap TQGLPKPHLLHAACKAHHFFKR-------NPHPDAANPWQLKSSADYLAETK-VRPLERR HIPK3_Hsap TQGLPGEQLLNVGTKSTRFFCK-------ETDM-SHSGWRLKTLEEHEAETG-MKSKEAR HIPK2_Hsap TQGLPAEYLLSAGTKTTRFFNR-------DTDS-PYPLWRLKTPDDHEAETG-IKSKEAR HIPK1_Hsap TQGLPAEYLLSAGTKTTRFFNR-------DPNL-GYPLWRLKTPEEHELETG-IKSKEAR CG17090_Dmel TQGLPTEHMLNSASKTSKFFYR-------DVDS-TYPFWRLKTTEEHEAETN-TKSKEAR HIPK4_Mmus TQGLPKPHLLHAARKAHHFFKR-------NPHPDATNPWQLKSSADYLAETK-VRPLERR HIPK3_Mmus TQGLPGEQLLNVGTKSTRFFCR-------ETDM-SHSGWRLKTLEEHEAETG-MKSKEAR HIPK2_Mmus TQGLPAEYLLSAGTKTTRFFNR-------DTDS-PYPLWRLKTPDDHEAETG-IKSKEAR HIPK1_Mmus TQGLPAEYLLSAGTKTTRFFNR-------DPNL-GYPLWRLKTPEEHELETG-IKSKEAR hpk-1_Cele TQGLPPTSMLESASKLHRFFKEVKSESPNHTNV-GGSYYRLKTVEEYEASSSTAKSKETR HIPKa_Spur VVALPGLSHLNLKNKSADFSIR-------GTTM-SSSTWLLKACSKRPSETG-VSD-SRS HIPKb_Spur TQGLPAEHLLSAATKTTRFFKR-------DIES-NFPLWRLKNPEEHETETS-VKSKEAR AqueK114_Aque TLGPLPHHLMRNITKATRFFNC-------DP---VTSTWSLKSISQYTQETG-IQSKESR . . : * * : ** . .: . HIPK4_Hsap KYMLKSLDQIETVN-GGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSA HIPK3_Hsap KYIFNSLDDVAHVN-TVM-----DLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAE HIPK2_Hsap KYIFNCLDDMAQVN-MTT-----DLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIE HIPK1_Hsap KYIFNCLDDMAQVN-MST-----DLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLK CG17090_Dmel KYIFNCLDDIGQVN-VPT-----DLEGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAE HIPK4_Mmus KYMLKSLDQIETVN-GGGAVSRLSFPDREALAEHADLKSMVELIKRMLTWESHERISPSA HIPK3_Mmus KYIFNSLDDIVHVN-TVM-----DLEGGDLLAEKADRREFVNLLKKMLLIDADLRITPIE HIPK2_Mmus KYIFNCLDDMAQVN-MTT-----DLEGSDMLVEKADRREFIDLLKKMLTIDADKRVTPIE HIPK1_Mmus KYIFNCLDDMAQVN-MST-----DLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLK hpk-1_Cele KYIFNVIDDISRVC-YGF-----ESDPVEHLCDRIDRQEFVDVLKKMLVLNPDFRITPAE HIPKa_Spur NYLFNTINDMLHLF---------------------------------------------- HIPKb_Spur KYIFNCLDDIAGVN-LPT-----DLEGSDYLAEKADRREFVELLKKMLTIDPDKRITPLE AqueK114_Aque KYIFRSLLDMNHLPPLAA-----GIDNREAILTSVDRMEFISLLSRMLSLDPTQRIRPLS :*::. : :: : HIPK4_Hsap ALRHPFVSMQQLRSAHETTHYY----QLSLRSYRL------S------------------ HIPK3_Hsap TLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSHLNSCD---TNNHNKT---SLLRPVAS HIPK2_Hsap TLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYD---TVNQSKT---PFITHVAP HIPK1_Hsap TLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYD---TVSQIKS---PFTTHVAP CG17090_Dmel ALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRRGD--FH---TVQ-PAS---TLVTNFVP HIPK4_Mmus ALRHPFVSMQQLRSAHEATRYY----QLSLRGCRL------S------------------ HIPK3_Mmus TLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSPS-SCE---TNNHSKM---SLLRPVAS HIPK2_Mmus TLNHPFVTMTHLLDFPHSAHVKSCFQNMEICKRRVNMYD---TVNQSKT---PFITHVAP HIPK1_Mmus TLNHQFVTMSHLLDFPHSSHVKSCFQNMEICKRRVHMYD---TVSQIKS---PFTTHVAP hpk-1_Cele GLESKFVTMTHINGYNFANYVHEAHKRMEICRKPGPAMA---TPY-RAANVATPITPVEK HIPKa_Spur -----------------------------ICKSDR-TCS---LNYHTHE---SLLKVKAS HIPKb_Spur ALNHPFVSLSHLAEYAHCRNTKASVRAMEVCKRGTQLFE---NTNQSKY---AFLTHLAS AqueK114_Aque ALQSPFITMQHLATHTNTQTVWSWIQAMAVCHQPRLSTTPLSINTHPSL---QLLGHTGL : HIPK4_Hsap -----------------------------------------------------LQVEGKP HIPK3_Hsap SSTATLTANFT----KIGTLRSQAL------TTSA------------------------- HIPK2_Hsap STSTNLTMTFNN---QLTTVHNQAP------SSTSATISLANPEVSILNYPSTLYQPSAA HIPK1_Hsap NTSTNLTMSFSN---QLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAA CG17090_Dmel SSTENMTFTINN---QLTSQ--------------V------------------------- HIPK4_Mmus -----------------------------------------------------LQVDGKP HIPK3_Mmus NGTAALAANFT----KVGTLRSQAL------TTSA------------------------- HIPK2_Mmus STSTNLTMTFNN---QLTTVHNQAP------TTSSATLSLANPEVSILNYQSALYQPSAA HIPK1_Mmus NTSTNLTMSFSN---QLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAA hpk-1_Cele PPAPKLQQPMIAVLPQLNQI----A------ATNIPPVP-TQPDL--------------- HIPKa_Spur IGNAPISKN--------------------------------------------------- HIPKb_Spur STCTILAIK------ELPT-------------ISTEILKLENHELHLFSYYSAVYQPPQI AqueK114_Aque TGGGVLPTS--------------------------------CCR---------------- HIPK4_Hsap PTPVVAA-----E--DG------------------------------------------- HIPK3_Hsap --HSVVHHGIPLQ--AGTAQF-----------G-CGDAFQQTL---------------II HIPK2_Hsap SMAAVAQRSMPLQ--TGTAQI-----------CARPDPFQQAL---------------IV HIPK1_Hsap PVPGVAQQGVSLQ--PGTTQI-----------CTQTDPFQQTF---------------IV CG17090_Dmel --QRLVRDGRPLA-YEGLYQIYNGRSVARQYPQTRTDSFQHQLV------------SNIL HIPK4_Mmus PPPVIASA----E--DG------------------------------------------- HIPK3_Mmus --HSVVHHGIPLQ--AGTAQF-----------G-CGDAFHQTL---------------II HIPK2_Mmus SMAAVAPRSMPLQ--TGTAQI-----------CARPDPFQQAL---------------IV HIPK1_Mmus PVPGVAQQGVSLQ--PGTTQI-----------CTQTDPFQQTF---------------IV hpk-1_Cele --TNLMHHYSQMAAATGSAAT-----------A--AQFFYQPLPPAPLFQYAQLHHPFAA HIPKa_Spur ------------------------------------------------------------ HIPKb_Spur A-QRVSQNTNQPQ--PATTQY------------PRPDPFQQVM---------------IM AqueK114_Aque ---------QSLQ--TGLYQ------------------------------T--------- HIPK4_Hsap -TPYYCLAEEKEA--AGMGSVAGSSPFFREEKAPGMQRAIDQLDDLS------------- HIPK3_Hsap CPPAIQGIPATHGKPTSY-SIRVDNTVPLVTQAPAVQPLQIRPGVLS------------- HIPK2_Hsap CPPGFQGLQASPSKHAGY-SVRMENAVPIVTQAPGAQPLQIQPGLLAQ------------ HIPK1_Hsap CPPAFQTGLQATTKHSGF-PVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLH CG17090_Dmel CPPSYQTMPS-PTKHV------------VVGSATMQPPLQVPPQQYVNV----------- HIPK4_Mmus -PPYYRLAEEEET--AGLGGVTGSGSFFREDKAPGMQRAIDQLDDLS------------- HIPK3_Mmus CPPAIQGIPAAHGKPTSY-SIRVDNTVPLVTQAPAVQPLQIRPGVLSQ------------ HIPK2_Mmus CPPGFQGLQASPSKHAGY-SVRMENAVPIVTQAPGAQPLQIQPGLLAQ------------ HIPK1_Mmus CPPAFQTGLQATTKHSGF-PVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLH hpk-1_Cele RPPHFLSLAT-PS-----------------HMVPQFVPVPIMDPS--------------- HIPKa_Spur ------------------------------------------------------------ HIPKb_Spur YSPGFEGVLGLPSSHLGV-SLEK------------------------------------- AqueK114_Aque ------------------------------------------------------------ HIPK4_Hsap -------------------------------------------------LQEAGH----- HIPK3_Hsap -------------------------------------QTWSGRTQQ-MLVP-AWQQVTPL HIPK2_Hsap -------------------------------------QAWPSGTQQ-ILLPPAWQQLTGV HIPK1_Hsap PQVATITPQYAVPFTLS----CAAGRPALVEQTAAVLQAWPGGTQQ-ILLPSTWQQLPGV CG17090_Dmel ------------PVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVP-SWPQQAPA HIPK4_Mmus -------------------------------------------------LQEARR----- HIPK3_Mmus -------------------------------------QTWSGRTQQ-MLIP-AWQQVTPM HIPK2_Mmus -------------------------------------QAWPGGAQQ-ILLPPAWQQLTGV HIPK1_Mmus PQVATITPQYAVPFTLS----CAAGRPALVEQTAAVLQAWPGGTQQ-ILLPSAWQQLPGV hpk-1_Cele ----------------------------------MLQGQWPPGAAQQFAVL-AND----- HIPKa_Spur ------------------------------------------------------------ HIPKb_Spur ------------------------------------------------------------ AqueK114_Aque ------------------------------------------------------------ HIPK4_Hsap ----------------------GLWGETCTNA--VSDMMVPLKAA-ITGHHVP---DSGP HIPK3_Hsap APAT----TTLTSESVAGSHRLGDWGKMISCSNHYNSVM--PQP--LLTNQIT---LSAP HIPK2_Hsap ATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIM--QQPA-LLTGHVT---LPAA HIPK1_Hsap ALHNSVQPTAMIPEAMGSGQQLADWRQAHSHGNQYSTIM--QQPS-LLTNHVT---LATA CG17090_Dmel HSLIVDSTP----------------------------LF--NVEEI-YPKHHLNLPRNDL HIPK4_Mmus ----------------------GLWSDTRADM--VSDMLVPLKVA-STSHRVP---DSGP HIPK3_Mmus APAA----ATLTSEGMAGSQRLGDWGKMIPHSNHYNSVM--PPP--LLTNQIT---LSAP HIPK2_Mmus ATHTSVQHAAVIPETMAGTQQLADWRNTHAHGSHYNPIM--QQPA-LLTGHVT---LPAA HIPK1_Mmus ALHNSVQPAAVIPEAMGSSQQLADWRNAHSHGNQYSTIM--QQPS-LLTNHVT---LATA hpk-1_Cele -------------------------------------IM--RVPAPQGINQMF---ASTP HIPKa_Spur ------------------------------------------------------------ HIPKb_Spur ------------------------------------------------------------ AqueK114_Aque ---------AVIP----------------------------HNGA-HLVCHVA---PSTF HIPK4_Hsap EPILAFYSSRLAGRHKARKPP------AGSKSDSNF----S-NLIRLSQV---------- HIPK3_Hsap QPVSVGI------AHVVWPQP------ATTKKNKQC-QNRG-ILVKLMEWEPGR-EEI-- HIPK2_Hsap QPLNVGV------AHVMRQQP------TSTTSSRKSKQHQS-SVRNVSTCEVSSSQAI-- HIPK1_Hsap QPLNVGV------AHVVRQQQ------SSSLPSKKNKQSA--PVSSKSSLDVLPSQVY-- CG17090_Dmel KKES--P------AHHIAKGNSYRVPR---HEKKEH-QQLSPVKKRVKESSPPH-QQRYQ HIPK4_Mmus EPILAFYGSRLTGRHKARKAP------AGSKSDSNF----S-NLIRLSQA---------- HIPK3_Mmus QPISVGI------AHVVWPQP------ATTKKNKLC-QNRG-ILVRLMEWEPGR-EEI-- HIPK2_Mmus QPLNVGV------AHVMRQQP------TSTTSSRKSKQHQS-SVRNVSTCEVTSSQAI-- HIPK1_Mmus QPLNVGV------AHVVRQQQ------SSSLPSKKNKQSA--PVSSKSSLEVLPSQVY-- hpk-1_Cele QTFS--L------PQFL----SSSIPSATTAFNGNA-PNIP-FPEENSSWAL-------- HIPKa_Spur ------------------------------------------------------------ HIPKb_Spur ---------------------------------------------------ITSGVVI-- AqueK114_Aque GYLPVSH------SHLIQTHQ------RET---------H--PVLT-------------- HIPK4_Hsap ------------------------------------------------------------ HIPK3_Hsap -----------------NAF-SWSNSLQNTNIPHSAFISPKIINGKDVE----EVSCIET HIPK2_Hsap -----------------SSP-QRSKRVKENTPPRCAMV---------------------- HIPK1_Hsap -----------------S------------------LV---------------------- CG17090_Dmel RAAHVSPQYHAHHNCNYGNGSGYSAS-AGSVVASSAASSSNIVNGSSSSSHHHHVPVAHA HIPK4_Mmus ------------------------------------------------------------ HIPK3_Mmus -----------------NAF-RWSNSLQNTNIPHSAFISPKIISGKEVE----EVSCVDT HIPK2_Mmus -----------------SSP-QRSKRVKENTPPRCAMV---------------------- HIPK1_Mmus -----------------S------------------LV---------------------- hpk-1_Cele -----------------GTAA--------------------------------------- HIPKa_Spur ------------------------------------------------------------ HIPKb_Spur -----------------YSV-SLVKRLIEIPL---------------------------- AqueK114_Aque ---------------------------------------------------TG------- HIPK4_Hsap -----SPED--DRPC------------R-----------GSSWE-----EGEHLG-ASAE HIPK3_Hsap QDNQNSEGE--ARNC------------C-----------ETSIR----QDSDSSV-SDKQ HIPK2_Hsap --------H--SSPA------------C-----------STSVTCGWGDVASSTT-RERQ HIPK1_Hsap --------G--SSPL------------R-----------TTSS------YNSLVP-VQDQ CG17090_Dmel QPYSSSSGHHIVSNCNANGGAGGAVVYQQPPAHAHQQHGQQPH-----PQSSQHP-QHVK HIPK4_Mmus -----SPED--AGPC------------R-----------GSGWE-----EGEGRT-TSTE HIPK3_Mmus QDNHTSEGE--AGTC------------R-----------EASV------RQDSSV-SDKQ HIPK2_Mmus --------H--SSPA------------C-----------STSVTCGWGDVASSTT-RERQ HIPK1_Mmus --------G--SSPL------------R-----------TTSS------YNSLVP-VQDQ hpk-1_Cele ------------------------QQQQ-----------QQAQ-----RAQSMINGNVKV HIPKa_Spur ------------------------------------------------------------ HIPKb_Spur ------------------------------------------------------------ AqueK114_Aque ---------------------------------------------QW------------- HIPK4_Hsap PLAILQRDEDGPNIDNMTMEAERPDPELFDP-SS--CPGE----------------WLSE HIPK3_Hsap RQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSLSS HIPK2_Hsap RQTIVIPDTPSPTVSVITISSDTDEEEEQKHA---------------------------- HIPK1_Hsap HQPIIIPDTPSPPVSVITIRSDTDEEEDNKYK---------------------------- CG17090_Dmel QPTITIHDTPSPT-AVITISDSEDEGGEAGG----------------------------- HIPK4_Mmus PSVIPQREGDGPGIKDRPMDAERPGPELFDP-SS--CPGE----------------WLSE HIPK3_Mmus RQTIIIADSPSPAVSVITISSDSDDEETSPRPSLRECKGSLDCEACQSTLNIDRMCSLSS HIPK2_Mmus RQTIVIPDTPSPTVSVITISSDTDEEEEQKHA---------------------------- HIPK1_Mmus HQPIIIPDTPSPPVSVITIRSDTDEEEDNKYK---------------------------- hpk-1_Cele KPLAAQPKKNSPAPSVITLSSDEDSNGAG------------------------------- HIPKa_Spur ------------------------------------------------------------ HIPKb_Spur ------------------------------------------------------------ AqueK114_Aque ---------------------------------------------------------IL- HIPK4_Hsap PDCTLESVR--------------------------------------------------- HIPK3_Hsap PDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDT---VDGSPTSDSSGHDSP----F-- HIPK2_Hsap PTSTVSKQ------------------RKNVISCVT---VHDSPYSDSSSNTSP----Y-- HIPK1_Hsap PSSSGLKP------------------RSNVISYVT---VNDSPDSDSS-LSSP----Y-- CG17090_Dmel AQVPVLKQ------------------RAHAQSQTSGSLLQHAPSSSCS-RSSAHQQPHPH HIPK4_Mmus PEWTLEGIR--------------------------------------------------- HIPK3_Mmus PDSTLSTSSSGQSSPSPCKRPNSMSDDEQESGCET---VDGSPTSDSSGHDSP----F-- HIPK2_Mmus PTSTVSKQ------------------RKNVISCVT---VHDSPYSDSSSNTSP----Y-- HIPK1_Mmus PNSSSLKA------------------RSNVISYVT---VNDSPDSDSS-LSSP----H-- hpk-1_Cele SSNSGSTT------------------RTGAVNPVR---NDTLPMGN-------------- HIPKa_Spur ------------------------------------------------------------ HIPKb_Spur ------------------------------------------------------------ AqueK114_Aque ------------------------------------------------------------ HIPK4_Hsap ------------------------------------------------------------ HIPK3_Hsap AESTFVEDTHENTELVSS-ADT-------------------E--T--------------- HIPK2_Hsap SVQQRAGH--NNANAFDTKGSL-------------------ENHC--------------- HIPK1_Hsap STDTLSALRGNSGSVLEGPGRV-------------------VADG--------------- CG17090_Dmel PQQQQQQQI--NYGDHDPEDARRRHHAAAAAAQQQQQYQPQPPPQQVLPQPQPSIKYEPG HIPK4_Mmus ------------------------------------------------------------ HIPK3_Mmus AENSFVEDAHQNTELGTC-AGP-------------------E--A--------------- HIPK2_Mmus SVQQRTGH--NGTNTLDTKGGL-------------------ENHC--------------- HIPK1_Mmus PTDTLSALRGNSGTLLEGPGRP-------------------AADG--------------- hpk-1_Cele ------------------------------------------------------------ HIPKa_Spur ------------------------------------------------------------ HIPKb_Spur ------------------------------------------------------------ AqueK114_Aque ------------------------------------------------------------ HIPK4_Hsap ------------------------------------------------------------ HIPK3_Hsap ------------------------------------------------------------ HIPK2_Hsap ------------------------------------------------------------ HIPK1_Hsap ------------------------------------------------------------ CG17090_Dmel QSQKKRILAMAQSECGYQPQVPSQPSSSASLPHIPTKQEPAEFYPEYAAAPPQQLDTKRS HIPK4_Mmus ------------------------------------------------------------ HIPK3_Mmus ------------------------------------------------------------ HIPK2_Mmus ------------------------------------------------------------ HIPK1_Mmus ------------------------------------------------------------ hpk-1_Cele ------------------------------------------------------------ HIPKa_Spur ------------------------------------------------------------ HIPKb_Spur ------------------------------------------------------------ AqueK114_Aque ------------------------------------------------------------ HIPK4_Hsap -----------GPRAQGLPP---------------------------------------- HIPK3_Hsap ---------KPAVCSVVVPPVELENG------------LNADEHMANTDSICQPLIKGRS HIPK2_Hsap ---------TGNPRTIIVPPLKTQASEVLVECDSLVP-VNTSHHSSSYKSKSSSNVTSTS HIPK1_Hsap ---------T-GTRTIIVPPLKTQLGDCTV-----------ATQASGLLSNKTKPVASVS CG17090_Dmel SWAPTSSGSGVSALPLAHPKREAP------------------------------------ HIPK4_Mmus -----------GSRAQGLPA---------------------------------------- HIPK3_Mmus ---------KPAVGTAVEPPVGRESG------------LSVDEHMANTDSTCQPLRKGQP HIPK2_Mmus ---------TGNPRTIIVPPLKTQASEVLVECDSLGPAISASHHSSSFKSKSSSTVTSTS HIPK1_Mmus ---------I-GTRTIIVPPLKTQLGDCTV-----------ATQASGLLSSKTKPVASVS hpk-1_Cele ---------TIKTEDILVPPTTFD------------------------------------ HIPKa_Spur ------------------------------------------------------------ HIPKb_Spur ------------------------------------------------------------ AqueK114_Aque ------------------------------------------------------------ HIPK4_Hsap ------------------------------------------------------------ HIPK3_Hsap APGRLNQPSAVGTRQQKLTSAFQQ------------------------------QHLNFS HIPK2_Hsap GHSSGSSSGAITYRQQRPGPHFQQQ-----------------------------QPLNLS HIPK1_Hsap GQSSGCCITPTGYRAQRGGTSA--A-----------------------------QPLNLS CG17090_Dmel ------SVAPISYVAPSVAPPLAHSKSSSASSSSSISAATAAAAAAAAAAAASVGPPSWG HIPK4_Mmus ------------------------------------------------------------ HIPK3_Mmus APGKLHQPPALGARQQKPAAAFPQ------------------------------QHLNLS HIPK2_Mmus GHSSGSSSGAIAYRQQRPGPHFQQQ-----------------------------QPLNLS HIPK1_Mmus GQSSGCCITPTGYRAQRGGASA--V-----------------------------QPLNLS hpk-1_Cele ------G--QLPNLQYF------------------------------------------- HIPKa_Spur ------------------------------------------------------------ HIPKb_Spur ------------------------------------------------------------ AqueK114_Aque ----------------EPTTRLQQQ-----------------------------QQQQQQ HIPK4_Hsap --------------------R--------------RSHQHGPPRG--------------- HIPK3_Hsap QVQHFGSG--HQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHA-HLAG----- HIPK2_Hsap QAQQHITTD------RTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHP-HLAAA---- HIPK1_Hsap QNQQSSAAPTSQERSSNPAPRRQQAFVAP-LSQAPYTFQHGSPLHSTGHP-HLAP----- CG17090_Dmel PPQVYRQP--SQPPPGSVGLPGSTQPPPSSVAPHPHHHSHGH-------H-HHQAG---- HIPK4_Mmus --------------------H--------------HPHPHGPPR---------------- HIPK3_Mmus QVQHFGTG--HQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHA-HLAG----- HIPK2_Mmus QAQQHMAAD------RTGSHRRQQAYITPTMAQAPYTFPHNSPSHGTVHP-HLAA----- HIPK1_Mmus QNQQSSSASTSQERSSNPAPRRQQAFVAP-LSQAPYAFQHGSPLHSTGHP-HLAP----- hpk-1_Cele ------------------------------------------------------------ HIPKa_Spur ---------------------EIEALISNHVKERPFCLTHGAVYQTVFHH-HIKN----- HIPKb_Spur ------------------------------------------------------------ AqueK114_Aque QQQ-----------------------------------QHGGGGGGGVYAHHLCTCHQHS HIPK4_Hsap ------------------------------------------------------------ HIPK3_Hsap ----------------NTHLGGQPTLLPYPSS---ATLSSAAPVAHLLASPC-TSRPMLQ HIPK2_Hsap --------------AAAAHLPTQPHLYTYTAP---AALGSTGTVAHLVASQG-SARHTVQ HIPK1_Hsap ---------------APAHLPSQAHLYTYAAPTSAAALGSTSSIAHLFSPQG-SSRHAAA CG17090_Dmel -----------------TPLGGSP--------------SST-AAAALLQPDIYAQGDIYR HIPK4_Mmus ------------------------------------------------------------ HIPK3_Mmus ----------------STHLGGQPTLLPYPSS---ASLSSAAPVAHLLASPC-TSRPMLQ HIPK2_Mmus ----------------AAHLPTQPHLYTYTAP---TALGSTGTVAHLVASQG-SARHTVQ HIPK1_Mmus ---------------APAHLPSQPHLYTYAAPTSAAALGSTSSIAHLFSPQG-SSRHAAA hpk-1_Cele ------------------------------------------PGSHLFDPK--------- HIPKa_Spur ------------------------------------------------------------ HIPKb_Spur ------------------------------------------------------------ AqueK114_Aque QSQQQVILPSDQVVTAATHLPTD------------------------------------- HIPK4_Hsap ------------------------------------------------------------ HIPK3_Hsap HPTYNISHPSGIVHQVPVG---LNPRLLPSPTIHQTQYKPIFPPHSYIAASPA---YTGF HIPK2_Hsap H----TAYPASIVHQVPVS---MGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGY HIPK1_Hsap Y----TTHPSTLVHQVPVS---VGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGY CG17090_Dmel RPTVFVS-------QAAPSYAYANRAVVAPPPAHNSSSRQVIPSHPLPAHIQIPTQYSQF HIPK4_Mmus ------------------------------------------------------------ HIPK3_Mmus HPTYNISHPSGIVHQVPVG---INPRLLPSPTIHQTQYKPIFPPHSYIAASPA---YTGF HIPK2_Mmus H----TAYPASIVHQVPVS---MGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGY HIPK1_Mmus Y----TTHPSTLVHQVPVS---VGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGY hpk-1_Cele --------------------------TVA----------GLL-----------P------ HIPKa_Spur -----ISSSSSSSSSSPLS---VIPYTLTSPTIHWPEFQNIFKKHSRCASAL-------- HIPKb_Spur ------------------------------------------PPCALII----------- AqueK114_Aque ------------------S---ITNK--------------------------------LL HIPK4_Hsap ----ATSFL-----------QHVTGHH HIPK3_Hsap -PLSPTKLS-------------QYPYM HIPK2_Hsap -PLSPAKVN-------------QYPYI HIPK1_Hsap -PLSPTKIS-------------QYSYL CG17090_Dmel GPLSPAQVAASKHAAHFAPTNIWYGAE HIPK4_Mmus ----TTSFL-----------QHVGGHH HIPK3_Mmus -PLSPTKLS-------------QYPYM HIPK2_Mmus -PLSPAKVN-------------QYPYI HIPK1_Mmus -PLSPTKIS-------------QYSYL hpk-1_Cele NPFLD-------------TSHIPRAFN HIPKa_Spur ----------------------CYTVF HIPKb_Spur ------ASS-------------PFESS AqueK114_Aque -PLQLPAYH-------------PFSRL