CLUSTAL W (1.83) multiple sequence alignment HUNK_Hsap MPAAA-----------------------------GDGLLGEPAAPGGG--GGAEDAARPA HUNK_Mmus MPAAA-----------------------------GDGLLGEPAAPGGD--GGAEDTTRPA HUNKb_Spur MASAVVALP--SPHLNPTMSPAPVNRLGQETAPSSNGDVGRDVACVGD--GGEKKEDRGG HUNKa_Spur MSALK-----------------------------PLQYVA--TRPRSS--ITKRTSSMPT HUNKc_Spur MGDPP-----------------------------PL------------------------ AqueK060_Aque MDRDSFQVRDRFPGVTMTL-----------DASMTHGLRGRSNT---D--SCLQ---QLL AqueK061_Aque MSSND-----------------------------QGTTREESGGPPEERTTGATAGHRPA * HUNK_Hsap A-----ACEGSFL---PAWVSGVPRERLRDFQHHKRVGNYLI-GSRKLGEGSFAKVREGL HUNK_Mmus A-----ACEGSFL---PAWVSGVSRERLRDFQHHKRVGNYLI-GSRKLGEGSFAKVREGL HUNKb_Spur N-----TGNGGRDCGQPERRRR--KSRSDGVVVRKKVGGYIL-GD-VIGEGSFAKVRLGT HUNKa_Spur RRNYGPQLQGVMT---VVGRSALSKELMASYKHTKRLGPYLL-GP-TIGEGSFAKVKEAM HUNKc_Spur ------------------------------------------------------KLMPPL AqueK060_Aque D-----PIELSRL---PPAVAHVPKEDWKAYVHSKKVNNYLV-GA-TLGEGSFAKVKEAF AqueK061_Aque -------------------SAHSSQSSGSSSKHVKCIGRYVLIGH-SLGKGNFARVEAAA :: HUNK_Hsap HVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETENSYYLVM HUNK_Mmus HVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETENSYYLVM HUNKb_Spur HILTQEQVAVKVIDKKLIANRDYVRKNLRREATVLQKMRHTNIARLYEVLETASNYYLVM HUNKa_Spur HVLVGEKVAIKIIDKKAAREDAYLHKTLRREAGLLQLLGHAHIVRLLEVMETDNNLYLVL HUNKc_Spur -RLDPRYVALKVIEKRKIT-KPYVKKNLTREARIMSQLRHPNIVRLYETITSPQLYCLIM AqueK060_Aque HVLVGEKIALKIIDKKKAMKDSYVAKNFKREARLLQKLRHPNIVQLYEVIETENNYYLIT AqueK061_Aque HTLTRAKVAIKIIETDKIK-EEYVRKNLLREAQLMRRLRHPNIIRLYETMKTNNLYCLVT * :*:*:*:. *: *.: **. : : *.:* :* : : : . *: HUNK_Hsap ELCPGGNLMHKIY---EKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDED HUNK_Mmus ELCPGGNLMHKIY---EKKRLDEAEARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDED HUNKb_Spur ELAEGGTFMSFLC---KRRKLSERETRRYIRQLVTAVDHMHHLDVIHRDIKIENFLLDND HUNKa_Spur ELCGGGPLLDKVC---EKGGLEEGVARRYIKQVASAVYHMHQMGVVHRDLKVENLLLDDN HUNKc_Spur EYVPGRDLLTLVRG-QKGGRLKEGVARRFVRQLVSALHHMHEHGIVHSLANISRLETYLS AqueK060_Aque ELCSGGELMKHIY---KHGKLSEDETRRYVRQIVSAVDHLHKAGLIHRDLKVENLLLDGN AqueK061_Aque EVAEGGELLSFVRNDFKEKRLPEATTRPFIRQLTSALYYLHGNGIVHRDLKMENILLDKK * * :: : : * * :* :::*: :*: ::* .::* ::..: . HUNK_Hsap ------------N-NIKLIDFGLSNCAGI------------------------------- HUNK_Mmus ------------N-NIKLIDFGLSNCAGI------------------------------- HUNKb_Spur ------------Q-NLKVIDFGLSNIL--------------------------------- HUNKa_Spur ------------D-KIRIIDFGLSNFIGNLERETDLRDAKKRERDFSSRKQADVRASRRV HUNKc_Spur LSLSLSDVHTVKNYVAFRLDFGLSNQC--------------------------------- AqueK060_Aque ------------M-DLKLIDFGLSNEEFIV------------------------------ AqueK061_Aque ------------KRYVKIVDFGLSNAQ--------------------------------- :****** HUNK_Hsap ------------------------------------------------------------ HUNK_Mmus ------------------------------------------------------------ HUNKb_Spur ------------------------------------------------------------ HUNKa_Spur SRTVGGRNGATGDDGGGPGRPGEPKGVARARLPSDDGTKRRTRGSSLREDNGQETWRERA HUNKc_Spur ------------------------------------------------------------ AqueK060_Aque ------------------------------------------------------------ AqueK061_Aque ------------------------------------------------------------ HUNK_Hsap ------------------------------------------------------------ HUNK_Mmus ------------------------------------------------------------ HUNKb_Spur ------------------------------------------------------------ HUNKa_Spur GLQRKSSKEHPSMTRSNPKQNGVRFNGGNVRFPGQDVHRRMGAEEQDSPEKRRNMLRNRT HUNKc_Spur ------------------------------------------------------------ AqueK060_Aque ------------------------------------------------------------ AqueK061_Aque ------------------------------------------------------------ HUNK_Hsap ---LGYSDPFSTQCGSPAYAAPELL-ARKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPF- HUNK_Mmus ---LGYSDPFSTQCGSPAYAAPELL-ARKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPF- HUNKb_Spur ----GYDGFLRTQCGSPAYAAPEIF-CNSSYGPSVDVWSIGVNMYAMLTGELPFVVDPPN HUNKa_Spur LDVFGTRDFAGTLCGSPAYAAPEII-ARKRYGPKVDVWSIGVNAYAMLTGTLPFIVEPF- HUNKc_Spur ----GPEELFKTHCGSPEYAAPELYVAGRDYGPEVDIWSLGVIMFAMVTGKLPFTT-PHS AqueK060_Aque -DETGREIHCRTQCGSPAYAAPELL-GQKQYDRAVDIWSIGVNMYAMLTGCLPFTVEPF- AqueK061_Aque ----KAGALLQTHCGSPEYAAPELFIPGRHYGPEVDVWSLGVNMYAMLVGKLPFRS-PRQ * **** *****: *. :*:**:** :**:.* *** * HUNK_Hsap SLRALYQKMVDKEMNPL-------PTQLSTGAISFLRSLLEPDPVKRPNIQ--------- HUNK_Mmus SLRALYQKMVDKAMNPL-------PTQLSTGAVNFLRSLLEPDPVKRPNIQ--------- HUNKb_Spur NMSKLHARIMQGA--TI-------PDTLTKDCRDLLRRLLEPKELDRIKLP--------- HUNKa_Spur NLRQLLSKIQKGEAGPL-------PSGLSSGTE--------------------------- HUNKc_Spur ENR-RQ-HLLLQIKKGLKGVHDKEMAHLTDED-MALRLKVKPDKIQDVVLENKLDDVSAI AqueK060_Aque NITALHAKMLQNKMNPI-------PDHISANATDLLRRMLTASPDKRITMD--------- AqueK061_Aque GTK-KRQKLLEQISAGITEHHEKEMEHLSTSAVNLICHLLQPNSSRRASLD--------- :: : :: HUNK_Hsap ------QALA--NRWLNENYTGKV-PCNVTYPNRIS----LEDLSPSVVLHMTEKLGY-K HUNK_Mmus ------QALA--NRWLNENYTGKV-PCNVTYPNRIS----LEDLSPSVVLHMTEKLGY-K HUNKb_Spur ------DIMR--HPWMNRGYSRRL------YPSRFEDSTPKPLVDQRIIKAL-VQCGH-Q HUNKa_Spur ------------------------------------------------------------ HUNKc_Spur FNILMEEHLIKRGVWTGEH-TRPPTPQT-PTPADSA----R----SR------------T AqueK060_Aque ------ELIA--HPWLSEGHALPF-Q-PAPYPNVMT----QSQINNDIVDHITDVLKLGT AqueK061_Aque ------DVMH--HPWTTKDGAHQLIPYEYTPPDPIT----Q----NLVIELMQKVLGE-T HUNK_Hsap NSDVINTVLSNRACHILAIYFLLNKKLER------YLS---------------------- HUNK_Mmus NSDVINTVLSNRACHILAIYFLLNKKLER------YLS---------------------- HUNKb_Spur EDILTECVQENRPTSENAAYCLLAKRIAM------GWGY-P------------------- HUNKa_Spur ------------------------------------------------------------ HUNKc_Spur GSRAGSRSSSARPGSAYAVIFAIPSTIA-Y-K-DFF-V-TPLPPPE-SSSSPPLSPPESS AqueK060_Aque AMEIKQDLITNRATSLYAIYNLLASRLAR------Y------------------------ AqueK061_Aque PSQIKETVKRDRCDWLAAIYNLLMDQPEGRNVLQRMITADPIDKLVSSSDHQTIAEHLSL HUNK_Hsap ------------------------------------------------------------ HUNK_Mmus ------------------------------------------------------------ HUNKb_Spur ------------------------------------------------------------ HUNKa_Spur ------------------------------------------------------------ HUNKc_Spur SSPYYHLQNHLRHPTITSRIIFVTLLSPPESSSSPHNHLQNHLRHPTITSIIIFVTPQSP AqueK060_Aque ------------------------------------------------------------ AqueK061_Aque SQGYGHSQHSQEHNDATG------------------------------------------ HUNK_Hsap ------------------------------------------------------------ HUNK_Mmus ------------------------------------------------------------ HUNKb_Spur ------------------------------------------------------------ HUNKa_Spur ------------------------------------------------------------ HUNKc_Spur PESSSSPHNHLQNHLRHPTITSRIIFVTPQSPPESSSSPYYHLQNHLRHPTITSRIIFVT AqueK060_Aque ------------------------------------------------------------ AqueK061_Aque ------------------------------------------------------------ HUNK_Hsap ------------------------------------------------------------ HUNK_Mmus ------------------------------------------------------------ HUNKb_Spur ------------------------------------------------------------ HUNKa_Spur ------------------------------------------------------------ HUNKc_Spur LLSPPESSSKNKKIIDFELDVVEEEQTSWAQRTGLPPPCAKKSRPLGNATTANRVKAQTS AqueK060_Aque ------------------------------------------------------------ AqueK061_Aque ------------------------------------------------------------ HUNK_Hsap -------------------GKSDIQDS--------------------------------- HUNK_Mmus -------------------GKSDIQDS--------------------------------- HUNKb_Spur -------------------ESNNVLDSD--------------------R----------- HUNKa_Spur ------------------------------------------------------------ HUNKc_Spur YRMSTPGTGLSTPNQEYVYAHTDLLDASTDHILVPVPSFESLPTSNADLDDSKSPSVPWA AqueK060_Aque ------------------------------------------------------------ AqueK061_Aque --------------------------------ILNKPSFSMKHLRSKD-DDQQA------ HUNK_Hsap -------------------------------------LCYKTRLYQIEKYRAPKESYEAS HUNK_Mmus -------------------------------------ICYKTQLYQIEKCRATKEPYEAS HUNKb_Spur ------------------------------SEM----VSVLTGAGVDDTMEAEHEEKPSP HUNKa_Spur ------------------------------------------------------------ HUNKc_Spur NLHSKGRLRSGPKPRGGCMKQKTFKPITNVRVSFCGSTLEKNNGLQKEQKRALKEKQIPC AqueK060_Aque ----------------------------------------EKQF------PSKAPVR--- AqueK061_Aque ------------------HSR-----------------------------------AEYD HUNK_Hsap LDTWTRDLEF-----------------------------------------HAVQDKKPK HUNK_Mmus LDTWTRDFEF-----------------------------------------HAVQDKKPK HUNKb_Spur VLALRRPISG-----------------------------------------RGTRSMAAK HUNKa_Spur ------------------------------------------------------------ HUNKc_Spur TDDGTNDRAQDVNVGDMSKNFAGKHHNYHGYHLVGTPITTEGAASKTVDCVKTAESGKDK AqueK060_Aque --PRRRSFKK-----------------------------------------KI------- AqueK061_Aque ILSKAPDRRK-----------------------------------------HLTVDHKPL HUNK_Hsap EQEKR----------GDFLHRP-FSKKLDKNLPSHKQPSGSLMTQ---IQ--NTKA---- HUNK_Mmus EQEKR----------GDFLHRP-FSKKLDKNLPSHKQPSPSLITQ---LQ--STKA---- HUNKb_Spur EQNFD----------MENKLKSDRMKLENTNSPIEKTPKYSVSPTKREIQDDMRKA---- HUNKa_Spur ------------------------------------------------------------ HUNKc_Spur MKEVR----------LCVAHRE-FLQDGQRS--SGGRPAATPYS-TPRTR--DTDNELVL AqueK060_Aque ----------------------------SKDQGFYDEDDSDVSST---CT--APVK---- AqueK061_Aque GQLRNVHSAFYQSLFSNHTHHA-SGRRLNNDLSPHHHVDMGGVT---KRH--TSHHHD-- HUNK_Hsap ---------LLKDRK-----ASKSSFPDKDSF----GCRNIFRKTSDSNCVASSSMEFIP HUNK_Mmus ---------LLKDRK-----ASKSGFPDKDSF----VCRNLFRKTSDSNCVASSSMEFIP HUNKb_Spur ---------WSKLQT-----NSKNSDESTKDHSKNNSVRSTNSEGSDMNSTGSK-MDTGE HUNKa_Spur ------------------------------------------------------------ HUNKc_Spur TTKLYPP-TLESDEHTTQSDDASTPMPSKAIAGRFN-STSKKKKKEPCRVYSASTTSSIT AqueK060_Aque ---------LRKDVK-----KTTSA-GSGTG----HSRRPISEDFSDYHVPMSQ------ AqueK061_Aque EFYMGMGGLEPPPRP-----HSRMSAPEPLPIPFQK-SM---LNKSLYNYAP-SSNEQLP HUNK_Hsap VPP-------------------PRT---PRIVKKPEPHQPGPGSTGIPHKEDP------- HUNK_Mmus VPP-------------------PRT---PRIVKKLEPHQPGPGSASILPKEEP------- HUNKb_Spur APKQSKTKHVQKVPDNKTTSHLPRR----VHSSLPAKTRTLPSPNSAPSLQNNTCIFI-- HUNKa_Spur ------------------------------------------------------------ HUNKc_Spur VPS-------------------PRSLLHPSIASIHCK-------------KENTSIV-SN AqueK060_Aque -----RDEKSQAVPQD-TKSRFPRS---PVRYSHPQPSQPLPPAYTNKHYHNPSPLPSEQ AqueK061_Aque S---------------------ESPP--PTILTPDNM----------------------- HUNK_Hsap ------------------------------------------------------------ HUNK_Mmus ------------------------------------------------------------ HUNKb_Spur --VNG---KVTAPD------QMVGR--SAG----------RNAA----------QMPGK- HUNKa_Spur ------------------------------------------------------------ HUNKc_Spur ---FA---ILR---CSDNKGGTFAKLLKNGVPVKRNGQNKKKGEKERKNAVCKSPESPVC AqueK060_Aque YEIDTRTKRPTTHSGS---KEMVPP--PTG----------AWQS----------NPPSR- AqueK061_Aque -------------------HQENSP--RTG----------KGLA----------PTITT- HUNK_Hsap ------------------------LMLDMVRSFESVDRDD--H----V------------ HUNK_Mmus ------------------------LLLDMVRSFESVDRED--H----I------------ HUNKb_Spur -RHSF----------HGGEK-----MIYTKRGLERAKTVPAVH----I------------ HUNKa_Spur ------------------------------------------------------------ HUNKc_Spur RRTTVELTDREVRGQKFKMYDEMPQRALQKRPIRQVTRRE--QSYNYIKIIFIPTRVCLL AqueK060_Aque ---------------SGSRASMYSKLPSLNQSMQSVDLDSYDN----I------------ AqueK061_Aque ---------------SSSRRRSAGNLKPLMRKTLSASVDT--H----L------------ HUNK_Hsap --------------------EVL--------------SPSHHYRILNSPVSLA------- HUNK_Mmus --------------------ELL--------------SPSHHYRILSSPVSLA------- HUNKb_Spur --------------------ESL-----------------------------D------- HUNKa_Spur ------------------------------------------------------------ HUNKc_Spur VSSLFFHSFLSAYQFIYRMKM--------------TRHPPSHSRIQSADTA-SRKTSPLR AqueK060_Aque --------------------EFH-----------------------------D------- AqueK061_Aque --------------------EQGGGGGATSWKGKNQIGPVRRMSYEAPPVGWSSQS---- HUNK_Hsap -------------------------------------RR--------------------- HUNK_Mmus -------------------------------------RR--------------------- HUNKb_Spur ------------------------------------------------------------ HUNKa_Spur ------------------------------------------------------------ HUNKc_Spur RVVDISEQAMNSLVNEAIREKKTNQHVSGGDIVKSLQRHFSDLRKSQKRSPGYEMYTRFI AqueK060_Aque ------------------------------------------------------------ AqueK061_Aque -------------------------------------QF--------------------- HUNK_Hsap --NSSERTLS-PGLPSGSMSPLHTP-LHPTLV--SFA--HED---------KNSPPKEEG HUNK_Mmus --NSSERTLS-QGLLSGSTSPLQTP-LHSTLV--SFA--HEE---------KNSPPKEEG HUNKb_Spur -------------TKNGSDDPLTSVPDKETS----MDTQI--S-------ELHAP----- HUNKa_Spur ------------------------------------------------------------ HUNKc_Spur PVQTSEKTGNEIGMLRPSSSPVPRL-NVPKEPV--FN--IK---------ETLPVPPHPY AqueK060_Aque -------------VGSGTISPIGRA-K--------FF--MEDS-------DNGSPAA--- AqueK061_Aque --SGSQRSIS-RNGPADIQSLMADP-NQKFLLEPPSA--HGMKSESMELKSELFAMKKEV HUNK_Hsap LCCPPPVPSNGPMQPLGS------------------------------PNCVKSRGRFPM HUNK_Mmus VCSPPPVPSNGLLQPLGS------------------------------PNCVKSRGRFPM HUNKb_Spur ---YQPH-NAFPIHRLGSEYT--------LPSQA-HRHSSRYLPGSVSTSAVTSATHPPP HUNKa_Spur ------------------------------------------------------------ HUNKc_Spur LTP-PPPSSASAPPPVDK------------------------------AESPRGAGRAVM AqueK060_Aque ---TTPVNSGNPAMRQRRTASMRSRKNGIVPPSGDYSFKT-ELP--------TSAIMSEL AqueK061_Aque VGA-PGSKTDMSAEGLDN------------------------------DGTEQERGRSVY HUNK_Hsap MGIGQM-------------LRKRHQSLQPS--------ADRPLEASLPPLQPL-APVNLA HUNK_Mmus MGIGQM-------------LRKRHQSLQPS--------SERSLDASMSPLQPT-APSSLS HUNKb_Spur YQYAQHLQ----------YHSNRHQSLRRS-----RPHHQRSMTAPH--PQGR-SHSPLP HUNKa_Spur -------------------------------------------------------Y---- HUNKc_Spur A-TGIT-------------KRNAVSATDASGA-------------TLGQVEEWDATY-R- AqueK060_Aque IQVTQDMRMKKAEPLSRTEMRCRHHSIDMSISIRKKSVHDCTVHFEW--LSGG-SYQTFS AqueK061_Aque RSSSAK-------------NQPRLLSQIP-----------------------------EF HUNK_Hsap ------------------------------------------------------------ HUNK_Mmus ------------------------------------------------------------ HUNKb_Spur FPPASQISRAEERGSGKPAKAVAWQDPPATVVL--------SNNGPSRSIRNRQRE---- HUNKa_Spur ------------------------------------------------------------ HUNKc_Spur --------------------------------LERKVSATVKGAAYVRNMRNDQRTRAWV AqueK060_Aque ETCSDI------------------------------------------------------ AqueK061_Aque SASAKHIGIGG---------------------GEGGSEHVNGL----RIDVPTHRELPSI HUNK_Hsap ------------------------------------------FDMADGVKTQC HUNK_Mmus ------------------------------------------FDMADGVKGQC HUNKb_Spur ------------------------------------------LPNIKGFVGYM HUNKa_Spur -----------------------------------------------QQIKTF HUNKc_Spur A--------------------------------------DLASDFAPNNVSEQ AqueK060_Aque -----------------------------------------------ISRSKM AqueK061_Aque KTVKGEKISPGSRKKTFNLFGALRIKTAGSGGRSEDRASLTTQGSTPSSSDVV