CLUSTAL W (1.83) multiple sequence alignment IRAKd_b-2_Smoe MGAAMTPRSRSLDHRHRARRAPKMLVAAVIELLVLWAVLGRAALPGSQTQSLLRLQKLLG IRAKd_b-1_Smoe MGAAMTPRSRSLDRRHRARRAPTMLVAAVIELLVLWAVLGRAALPGSQTQSLLRLQKLLG IRAKd_a_Smoe MGPSIP-G----------------SIGAVVALLLVLAVEG-SSLPPSQIQSVLRLQRLLG **.::. :.**: **:: ** * ::** ** **:****:*** IRAKd_b-2_Smoe DPSALGGWSVNTS----FCSLPSSPMLNVSCAYADQS---GTQTVILLQIVGDKLPITVR IRAKd_b-1_Smoe DPSALGGWSANTS----FYSLV--------CHKTLSFFSIKNETLVTTKQVSHAFP-QVR IRAKd_a_Smoe YPSALAHIDSNATQGLDLCGIPPSLVFNLSCNSSAGS---FSSTIVSIQILGNA----TS ****. . *:: : .: * : ..*:: : :.. . IRAKd_b-2_Smoe LPDDFSIITLANTLVKFPDLRTLTLVSLGIWGLVPASLDHLRSLELLNLSSNFLSGSIPD IRAKd_b-1_Smoe LPDDFSIITLANTLVKFPDLRTLTLVSLGIWGLVPASLDHLRSLELLNLSSNFLSGSIPD IRAKd_a_Smoe LSRDFSMETLGNLLSALPELEILGLVHLGLWGSIPPKLDHLQSLRVLDLSENSISGALPD *. ***: **.* * :*:*. * ** **:** :*..****:**.:*:**.* :**::** IRAKd_b-2_Smoe RFSSLGSLQSLALDNNILRGTFPTALNVLPNLDTLQLSHNQIAGTIPSQISLFASLKTLD IRAKd_b-1_Smoe RFASLGSLQSLALDNNILRGTFPTALNVLPNLDTLQLSHNQIAGTIPSQISLFASLKTLD IRAKd_a_Smoe RLRALSRL------------------------EILQLKDNRLNGTLPGWIGELRSLRELD *: :*. * : ***..*:: **:*. *. : **: ** IRAKd_b-2_Smoe MDHNLLFGALPDSISNMR--VAETISISDNFLAGVVPNLSRVASLRTLNLAGNQLGPSFP IRAKd_b-1_Smoe MDHNLLFGALPDSISNMR--VAETISISDNFLAGVVPNLSRVASLRTLNLAGNQLGPSFP IRAKd_a_Smoe LSNNAITGKLPKSLFSSRRNRLERLVVSHNDFSGNLPDWSSDSLLVYFNAGANHIGPSFP :.:* : * **.*: . * * : :*.* ::* :*: * : * :* ..*::***** IRAKd_b-2_Smoe GLGQG--LVSANLERNRFSDSIP-DSLRGLSQLKLLNLSLNSIPGALPGWIFSLQSLETL IRAKd_b-1_Smoe GLGQG--LVSANLERNRFSDSIP-DSLRGLSQLKLLNLSLNSIPGALPGWIFSLQSLETL IRAKd_a_Smoe KLGYGGLLQSLLLGQNDITGGIPHDAAARLGGVRTMDLSYNELHGMPPAALFRLGHIETL ** * * * * :* ::..** *: *. :: ::** *.: * *. :* * :*** IRAKd_b-2_Smoe VLDHNRLSGTLPSAVTLASGLRYVDISTNLLMGEVPAELR--SGRITLHVEENCFSGQEI IRAKd_b-1_Smoe VLDHNRLSGTLPSAVTLASGLRYVDISTNLLMGEVPAELR--SGRITLHVEENCFSGQEI IRAKd_a_Smoe ALNGNQFLGVLPYNLSLSPSLALLDLSSNFFTGRVPASFLGSGGSVVVRFGKNCFAT--- .*: *:: *.** ::*:..* :*:*:*:: *.***.: .* :.::. :***: IRAKd_b-2_Smoe QLQQQQPQEYCLKAQRM----------IPRRWKGGVVAGIAGGVMAVGAAMALLLVILLR IRAKd_b-1_Smoe QLQQQQPQEYCLKAQRM----------IPRRWKGGVVAGIAGGVMAVGAAMALLLVILLR IRAKd_a_Smoe RVQQQYTRSHCDAAARKRAAASAAAASTPDSHDLAIIAGIVGGGIALVGAVAVFLCVLLR ::*** .:.:* * * * . .::***.** :*: .*:*::* :*** IRAKd_b-2_Smoe FSKRGKLKLKHAAATCANNSCADTASVGVPLELLHSTRYLAQSGTVGATGPNQCRVFSLL IRAKd_b-1_Smoe FSKRGKLKLKHAAATCANNSCADTASVGVPVELLHSTRYLAQSGTVGATGPNQCRVFSLL IRAKd_a_Smoe CLRQQKDD---KPVQYAASSCADTASIGVPSDLLSNARYLSQSIRLGVHSTSHNRVFSVP :: * . .. * .*******:*** :** .:***:** :*. ...: ****: IRAKd_b-2_Smoe ELEEATSRFSQGLLIGEGEYGKVFRGKLDDGTLVAIKCLVIDSRQEMKQLKAHLEFLSRI IRAKd_b-1_Smoe ELEEATSRFSQGLLIGEGEYGKVFRGKLDDGTLVAIKCLVIDSRQEMKQLKAHLEFLSRI IRAKd_a_Smoe ELEEATANFSLENLIGEGQHGKVFKGKLHDGTVAAVKCLTLDSRQDMRQLKIHVELLVKI ******:.** *****::****:***.***:.*:***.:****:*:*** *:*:* :* IRAKd_b-2_Smoe RHRHLVSLFGYCLEREKDGP-QHRRLYLVSEFIDNGTLRSHLFKR--------------- IRAKd_b-1_Smoe RHRHLVSLFGYCLEREKDGP-QHRRLYLVSEFIDNGTLRSHLFKR--------------- IRAKd_a_Smoe RHRHLVGYIGYSLDNVIDGARQCRKLYLVSEYIDNGTLRNHLSSKFVTGLLGLMFCFSDL ******. :**.*:. **. * *:******:*******.** .: IRAKd_b-2_Smoe ----KLKESLTWQNRLVAALGAGRGIHYLHTGVVPGIFNNDVRVTNVLLDHNFVGKVSDF IRAKd_b-1_Smoe ----KLKESLTWQNRLVAALGAGRGIHYLHTGVVPGIFNNDVRITNILLDHNFVGKVSDF IRAKd_a_Smoe PVEAEGREVLSWSQRLAAAIGAGRGIQYLHTGVVPGIFNNDVNITNVLMDQNCVAKFTDF : :* *:*.:**.**:******:***************.:**:*:*:* *.*.:** IRAKd_b-2_Smoe GLARHPESESYQSYGS----------------DLATDKRDVYNFGLILLEIVLGRPPTVD IRAKd_b-1_Smoe GLARHPESESYQSYGSDVSN-SSKVLVIIPTLKLATDKRDVYNFGLTLLEIVLGRPPTVD IRAKd_a_Smoe GIGKHARTSCDFDAKVYVQKTPAHIDLDHHRRKLASDKTDVYNFGFILLEILLGKPPTIE *:.:*..:.. . .**:** ******: ****:**:***:: IRAKd_b-2_Smoe NPM-AMKPKVQELVSSSSSVFRTEMVDSAISGTCSEDSLSTVLEIAAKCLSSDLTARPSM IRAKd_b-1_Smoe NPM-AMKPKVQELVSSSSSVFRTEMVDSAISGTCSEDSLSTVLEIAAKCLSSDLTARPSM IRAKd_a_Smoe DSKSSVHPK--EMLQ-TEHVPRYEVVDPAIIGNCVAESLTTVLEIAAKCLSEEPSSRPSM :. :::** *::. :. * * *:**.** *.* :**:***********.: ::**** IRAKd_b-2_Smoe EDVLWNLQYAVQVQDQRF------------------------------------------ IRAKd_b-1_Smoe EDVLWNLQYAVQVQDQRF------------------------------------------ IRAKd_a_Smoe EDVLWNLQYAAQVQDRRAMALGPDIRVSTLHSPPILRRAVAPCTLRRGYAGNLLRRGGFV **********.****:* IRAKd_b-2_Smoe ------------------------------------------------------------ IRAKd_b-1_Smoe ------------------------------------------------------------ IRAKd_a_Smoe GLTRHWRGNAVRDENAIAGKGEKSMLGAFSEEDEDCSDGSEEESSGEEEDFGFGEFRFAS IRAKd_b-2_Smoe ------------------------------------------------------------ IRAKd_b-1_Smoe ------------------------------------------------------------ IRAKd_a_Smoe DDGAEEGADDASEELDSFAERARRIDDLCAKVAQGKQISSADLIGLYSFRLDKFQRLAIE IRAKd_b-2_Smoe ------------------------------------------------------------ IRAKd_b-1_Smoe ------------------------------------------------------------ IRAKd_a_Smoe GFLKGSSVVVSAPTSSGKTLIAEAAAAATLAKCKRLFYTTPLKALSNQKFRDFRKIFGDS IRAKd_b-2_Smoe ------------------------------------------------------------ IRAKd_b-1_Smoe ------------------------------------------------------------ IRAKd_a_Smoe SVGLLTGDVSINRDAPIVIMTTEIMRNKFYLSAGNEDVLQDLDVVVLDEIHYISDLTRGT IRAKd_b-2_Smoe ------------------------------------------------------------ IRAKd_b-1_Smoe ------------------------------------------------------------ IRAKd_a_Smoe VWEETARVIYCPKRIKLVCLSATIANPDELAGWIAKVHGPTELITSYRRPVPLTWHISRR IRAKd_b-2_Smoe ------------------------------------------------------------ IRAKd_b-1_Smoe ------------------------------------------------------------ IRAKd_a_Smoe SQMLPLLNEKGTAINRKLLIDKKQLEEVNSRKIRGRISTLEKMTEEQLQVLLRVQVFLTI IRAKd_b-2_Smoe ------------------------------------------------------------ IRAKd_b-1_Smoe ------------------------------------------------------------ IRAKd_a_Smoe LFGQLSNSCISCQVPRISDTLKQMVERTMLPAIWFILSRRRCDEAVQYLQHANLLAEDEF IRAKd_b-2_Smoe ------------------------------------------------------------ IRAKd_b-1_Smoe ------------------------------------------------------------ IRAKd_a_Smoe QQIDLALKSFREQYPDAIREAAVRPLYQGVAAHHAGCLPLWKSFIEELFQKGLVKVVFAT IRAKd_b-2_Smoe -------------------SGEY------------------------------------- IRAKd_b-1_Smoe -------------------SGEY------------------------------------- IRAKd_a_Smoe ETLAAGINMPARTTVLSSFSGKYQRRISANVVLQMAGRAGRRGIDKEGHVVVVQTPFRGP **:* IRAKd_b-2_Smoe ----------------------------LEDSS--------------------------- IRAKd_b-1_Smoe ----------------------------LEDSS--------------------------- IRAKd_a_Smoe EECYKMLRTGLEPLVSQFTATYGMALNLLEDSAVESETLSSEQRQSFGEARSLIEQSFGN ****: IRAKd_b-2_Smoe ------------------------------------------------------------ IRAKd_b-1_Smoe ------------------------------------------------------------ IRAKd_a_Smoe YIGSEILTGARAKMVQISSEIETLESGQSTDSLSKLYEEKINEFNKMREKVETQERKERS IRAKd_b-2_Smoe ------------------------------------------------------------ IRAKd_b-1_Smoe ------------------------------------------------------------ IRAKd_a_Smoe LRFKFERHRLSFLQSQLKQLSLEQVPYVLLTYEDINTGEGHTLSVAVFHMTENNPFILGV IRAKd_b-2_Smoe ------------------------------------------------------------ IRAKd_b-1_Smoe ------------------------------------------------------------ IRAKd_a_Smoe NENHEPKVEDMDASFIGVGCDSFLYRFPLKVVRKVYRSTIGAEERTALKSNLADVQWEIV IRAKd_b-2_Smoe ------------------------------------------------------------ IRAKd_b-1_Smoe ------------------------------------------------------------ IRAKd_a_Smoe GNDNVSRCQSSFPPHGYEVPVPNTLTSECAMPEELVTAEKLLLMQQRSLGKWSRRLAEID IRAKd_b-2_Smoe ------------------------------------------------------------ IRAKd_b-1_Smoe ------------------------------------------------------------ IRAKd_a_Smoe EVEIDNLVAKVKQMREEKVARLKAKLERIGKRIKGMQPSGWKEFLQVVKILKDAGAMDRN IRAKd_b-2_Smoe ------------------------------------------------------------ IRAKd_b-1_Smoe ------------------------------------------------------------ IRAKd_a_Smoe THKLLPLGEIARAIRGSNELWLAIALRDEALLSLKPSELAAVAAALVTESPKSIPDNEYR IRAKd_b-2_Smoe ------------------------------------------------------------ IRAKd_b-1_Smoe ------------------------------------------------------------ IRAKd_a_Smoe TIYEPSAVVKEWVEKMQSERLWLYGLQENHNVEFACDLDPQLAGFVEAWAAGVNWKELEI IRAKd_b-2_Smoe ----------------------------------------------------GRE IRAKd_b-1_Smoe ----------------------------------------------------GRE IRAKd_a_Smoe EDIMDEGDFARLLRRTIDLLSQIPHLPHIDSELSKIAKEAARNMDRPPISEPVGE *