CLUSTAL W (1.83) multiple sequence alignment IRAKf_k-2_Smoe MGFLRHGS-------IL-----------------------------SLTGVVLLEIKKSL IRAKf_c-1_Smoe MSARIHGRRAGAPGKIDSVLFLAILALILASLPRHSAGEEDETVSWNDDVLGLLVFKAGL IRAKf_c-2_Smoe MSARIHGRRAGAPGKIDSVLFLAILALILASLPRHSTGEGDETVSWNDDVLGLLVFKAGL IRAKf_d-1_Smoe MSIGQQCR-------ILAIEFLVVLVAAFQA------------RALNEEGIALMAFRMQI IRAKf_d-2_Smoe MSIGQQCR-------ILAIEFLVVLVAAFQA------------RALNEEGIALMAFRMQI IRAKf_g_Smoe -------------------------------------------------GQALLAFKASL IRAKf_m-2_Smoe -------------------------------------------------GAVLLEIKKSF IRAKf_g-1_Smoe -------------------------------------------------GIALLAFKEGI IRAKf_m-1_Smoe -------------------------------------------------GAVLLEIKKSF IRAKf_g-2_Smoe -------------------------------------------------GIALLAFKEGI IRAKf_n-2_Smoe MSWFL---------------WLLLLAASLTPS----------LAQLSGDGIALLAVKKAL IRAKf_n-1_Smoe MSWFL---------------WLLLLAASLSAS----------LAQLSGDGIALLAVKKAL IRAKf_a_Smoe --------------------------------------------------------RADL IRAKf_k-1_Smoe MGFLRHGS-------IF-----------------------------SLTGVVLLEIKKSL IRAKf_b_Smoe MEARLD-----------MVVVVVVVFFLSLALPVES---SDIVLPWNDDVLGLIVFKADL : : IRAKf_k-2_Smoe -NNADN-VLYDWEGAIDRDPCFWRGVSCDNVTLAVIGLNLTQLGL---SGEISPAFGRLK IRAKf_c-1_Smoe -QDPRG-SLASWSE-ADSSPCNWTGIRCGSASGRVESVSLDGLAL---SGTIGRGLLKLE IRAKf_c-2_Smoe -QDPRG-SLASWSE-ADSSPCNWTGIRCGSASGRVESVSLDGLAL---SGTIGRGLLKLE IRAKf_d-1_Smoe TQDPTG-IFTSWNA-ADEDPCGWTGVFCDDD-NRVKKLLIHGAGL---AGTISPALSGLP IRAKf_d-2_Smoe TQDPTG-IFTSWNA-ADEDPCGWTGVFCDDD-NRVKKLLIHGAGL---AGTISPALSGLP IRAKf_g_Smoe -NDSAGALLLDWIE-SDSHPCRWTGVSCHPQTTKVKSLNLPYRRL---VGTISPELGKLD IRAKf_m-2_Smoe -SNAGN-ALYDWDGSADHDPCFWRGVTCDNVTLSVTGLNLTQLSL---SGVISPSVGKLK IRAKf_g-1_Smoe -QEAQF-LLGDWRR-SDATPCNWTGVECNGETGRVETLNLPRFHL---VGVISPEIGKLS IRAKf_m-1_Smoe -SNAGN-ALYDWDGSADHDPCFWRGVTCDNVTLSVTGLNLTQLSL---SGVISPSVGKLK IRAKf_g-2_Smoe -QEAQF-LLGDWRR-SDATPCNWTGVECNGETGRVETLNLPRFHL---VGVISPEIGKLS IRAKf_n-2_Smoe --DPSD-ALSGWNA-GSVDPCLWAGVSCAQ-DRRVTSLNLTGAFLGTCSSSHSDSWENLR IRAKf_n-1_Smoe --DPSD-ALSGWNA-GSVDPCLWAGVSCAQ-DRRVTSLNLTGAFLGTCSSSHSDSWENLR IRAKf_a_Smoe -HDPRR-ALASWSE-DSASPCNWTGIQCSPQSGRVTQL---------------------- IRAKf_k-1_Smoe -NNADN-VLYDWEGAIDRDPCFWRGVSCDNVTLAVIGLNLTQLGL---SGEISPAFGRLK IRAKf_b_Smoe -HDPRR-ALASWSE-DSASPCNWTGIQCSPQSGRVTQVTLDGLEL---SGPLGRGLLKLD :. : .* . ** * *: * * : IRAKf_k-2_Smoe SLQYLDLRENSLSGQIPDEIGQ-C-VNLKTIDLSFNAFHGDIPF-SISQLKQLENLILKN IRAKf_c-1_Smoe RLKTLSLSANNLSGNVVPELFR----MLDFVDLK-------------------------K IRAKf_c-2_Smoe RLKTLSLSANNLSGNVVPELFR----MLDFVDLK-------------------------K IRAKf_d-1_Smoe FLRTLSLSNNLLKGSIPSQL---------------------------SHISSLWKLNLSS IRAKf_d-2_Smoe FLRTLSLSNNLLKGSIPSQL---------------------------SHISSLWKLNLSS IRAKf_g_Smoe RLARLALHHNSFYGTIPSEL---------------------------------------- IRAKf_m-2_Smoe SLQYLDLRENSIGGQIPDEIGD-C-AVLKYIDLSFNALVGDIPF-SVSQLKQLETLILKS IRAKf_g-1_Smoe KLRRLGLHNNMISGKIPPSL---------------------------------------- IRAKf_m-1_Smoe SLQYLDLRENSIGGQVPDEIGD-C-AVLKYIDLSFNALVGDIPF-SVSQLKQLETLILKS IRAKf_g-2_Smoe KLRRLGLHNNMISGKIPPSL---------------------------------------- IRAKf_n-2_Smoe KLQVLSLQENSFSGGIPAELGA-L-SSLEVLDLEGNLLDGPIPP-AIASCRSLVHISLGR IRAKf_n-1_Smoe KLQVLSLQENSFSGGIPAELGA-L-SSLEVLDLEGNSLDGPIPP-AIASCRSLVHISLGR IRAKf_a_Smoe -LSLLDVSHNSFSGSVPPELFANCSKSLRYVFLSGNQLEGDLPD-SIASCESLEALGASE IRAKf_k-1_Smoe SLQYLDLRENSLSGQIPDEIGQ-C-VNLKTIDLSFNAFHGDIPF-SISQLKQLENLILKN IRAKf_b_Smoe HLQVLSLARNNLSGSISPQIRV-L-KSLRNLSLSHNALSGPLPGASLASLELLSLLDVSQ * * : * : * : .: IRAKf_k-2_Smoe NQLTGPIPSTLSQ--LPNLKTLDLAQNKLTGEIPTLLYW-SEVLQYLGLRDNLLTGNLSP IRAKf_c-1_Smoe NRLSGELPSPMGA----SIRYVDLSDNAFTGALARDFFGGGHLLRYLSLSKNRLTGQLSP IRAKf_c-2_Smoe NRLSGELPSPMGA----SIRYVDLSDNAFTGALARDFFGGGHLLRYLSLSKNRLTGQLSP IRAKf_d-1_Smoe NELAGTIPASIGK--IPGLRMLDLSSNLLTGAIPPQLFGNCSKLRFVSLSGNAL------ IRAKf_d-2_Smoe NELAGTIPASIGK--IPGLRMLDLSSNLLTGAIPPQLFGNCSKLRFVSLSGNAL------ IRAKf_g_Smoe ------------------------------------------------------------ IRAKf_m-2_Smoe NQLTGPIPSTLSQ--LPNLKTLDLAQNQLTGEIPTLLYW-SEVLQYLGLRDNSLSGTLSS IRAKf_g-1_Smoe ------------------------------------------------------------ IRAKf_m-1_Smoe NQLTGPIPSTLSQ--LPNLKTLDLAQNQLTGEIPTLLYW-SEVLQYLGLRDNSLSGTLSS IRAKf_g-2_Smoe ------------------------------------------------------------ IRAKf_n-2_Smoe NKLSGGIPASLGG--LSRLRHLSLTSNQLSSVIPPGLQGLCGTLEYLDLGSNFFIRGIPP IRAKf_n-1_Smoe NKLSGGIPASLGG--LSRLRHLSLTSNQLSSVIPPGLQGLCGTLEYLDLGSNFFIRGIPP IRAKf_a_Smoe NRLSGSIPAGVGS--LSRLGSLDLSHNSLSGEIPP------------------------- IRAKf_k-1_Smoe NQLTGPIPSTLSQ--LPNLKTLDLAQNKLTGEIPTLLYW-SEVLQYLGLRDNLLTGNLSP IRAKf_b_Smoe NSFSGSVPPELFANCSKSLRYVFLSGNQLEGDLPDSIAS-CESLEALGASENRLSGSIPA IRAKf_k-2_Smoe DMC-RLTGLWYFDIRSNNITGPIPENIGNCTSYEILDLSYNQLTGEIPFNIGF-LQVATL IRAKf_c-1_Smoe SLAANQTG------------------------------------------------LVTL IRAKf_c-2_Smoe SLAANQTG------------------------------------------------LVTL IRAKf_d-1_Smoe ------------------------------------------------------------ IRAKf_d-2_Smoe ------------------------------------------------------------ IRAKf_g_Smoe ------------------------------------------------------------ IRAKf_m-2_Smoe DMC-RLTGLWYFDVRSNNISGIIPDNIGNCTSFEILDLAYNRLNGEIPYNIGF-LQVATL IRAKf_g-1_Smoe ------------------------------------------------------------ IRAKf_m-1_Smoe DMC-RLTGLWYFDVRSNNISGIIPDNIGNCTSFEILDLAYNRLNGEIPYNIGF-LQVATL IRAKf_g-2_Smoe ------------------------------------------------------------ IRAKf_n-2_Smoe WLG-NCSKLQVLVLESNYLQGFIPSELGRLGMLQVLDVSMNRLTGQVPAALGDCLELSFL IRAKf_n-1_Smoe WLG-NCSKLQVLVLESNYLQGFIPSELGRLGMLQVLDVSMNRLTGQVPAALGDCLELSFL IRAKf_a_Smoe -------------------------ELGQCQMLVSLDLSYNLLSGEIPSFLESLSRLEVL IRAKf_k-1_Smoe DMC-RLTGLWYFDIRSNNITGPIPENIGNCTSYEILDLSYNQLTGEIPFNIGF-LQVATL IRAKf_b_Smoe GVG-SLSRLSSLDLSHNSLSGEIPPELGQCQMLVSLDLSYNLLSGEIPSFLESLSRLEVL IRAKf_k-2_Smoe SL------------------------QGNKLVGKIPDVIG-LMQALAVLDLSNNFLEGSI IRAKf_c-1_Smoe RI------------------------AENGFSGDLPDWIGKSLRALQELDLSWNGFQGSI IRAKf_c-2_Smoe RI------------------------AENGFSGDLPDWIGKSLRALQELDFSWNGFQGSI IRAKf_d-1_Smoe -------------------------------AGSLPVALGS-CGSLKFVDFSSNRLT--- IRAKf_d-2_Smoe -------------------------------AGSLPVALGS-CGSLKFVDFSSNRLT--- IRAKf_g_Smoe ------------------------------------------------------------ IRAKf_m-2_Smoe SL------------------------QGNQFSGKIPEVIG-LMQALAVLDLSDNRLVGDI IRAKf_g-1_Smoe ------------------------------------------------------------ IRAKf_m-1_Smoe SL------------------------QGNQFSGKIPEVIG-LMQALAVLDLSDNRLVGDI IRAKf_g-2_Smoe ------------------------------------------------------------ IRAKf_n-2_Smoe VLTHPSSCVSPFNCTTGDGVRGVDKAEFNQFDGPLPSSIS-KLPKLQVLWAPHAALTGGI IRAKf_n-1_Smoe VLTHPSSCVSPFNCTTGDGVRGVDKAEFNQFDGPLPSSIS-KLPKLQVLWAPHAALTGGI IRAKf_a_Smoe RL------------------------PGNSFSGGVPEWIVTGFPELQELNLAENDLGGTL IRAKf_k-1_Smoe SL------------------------QGNKLVGKIPDVIG-LMQALAVLDLSNNFLEGSI IRAKf_b_Smoe RL------------------------PGNSFSGGVPEWIVTGFPELQELNLAENDLGGTL IRAKf_k-2_Smoe PSILGNLTFTGKLYLHGNMLTGVIPPELGNMTKLSYLQLNDNNLTGQIPPELGSLSELFE IRAKf_c-1_Smoe PPSLATLSSLRSLNLAGNNLTGVVPQSLLQLLRLSSLDLSSNHLGGKIPFGLFS-SSLQF IRAKf_c-2_Smoe PPSLATLSSLRSLNLAGNNLTGVVPQSLLQLLRLSSLDLSSNHLGGKIPFGLFS-SSLQF IRAKf_d-1_Smoe ---------------------GSVPAEIAFLDELLLLLIQENSLSGDFPSEVLYLPSLDI IRAKf_d-2_Smoe ---------------------GSVPAEIAFLDELLLLLIQENSLSGDFPSEVLYLPSLDI IRAKf_g_Smoe ------------------------------------------------------------ IRAKf_m-2_Smoe PALLGNLTYTGKLYLHGNLLTGTIPPELGNMTKLSYLQLNDNQLTGEIPSELGSLSELFE IRAKf_g-1_Smoe ------------------------------------------------------------ IRAKf_m-1_Smoe PPLLGNLTYTGKLYLHGNLLTGTIPPELGNMTKLSYLQLNDNQLTGEIPSELGSLSELFE IRAKf_g-2_Smoe ------------------------------------------------------------ IRAKf_n-2_Smoe PDGWGACERLRSLNLAGNSFTGDFPQGLGKCSSLTYLDLSLNRLEAQLPPQLPT-SCMIV IRAKf_n-1_Smoe PDGWGACERLRSLNLAGNSFTGDFPQGLGKCSSLTYLDLSLNRLEAQLPPQLPT-SCMIV IRAKf_a_Smoe PSSIGSMKALRRLYLHNNNLQGALPPALAGCFNLSTIDLSSNNFSGAIPDEIFE-LELER IRAKf_k-1_Smoe PSILGNLTFTGKLYLHGNMLTGVIPPELGNMTKLSYLQLNDNNLTGQIPPELGSLSELFE IRAKf_b_Smoe PSSIGSMKALRRLYLHNNNLQGALPPTLGGCFNLSTIDLSSNNFSGAIPDEIFE-LELES IRAKf_k-2_Smoe LDLSNNKFSGPFPKNV-------------------------------------------- IRAKf_c-1_Smoe LNLSRNEFLGDFPIW--------------------------------------------- IRAKf_c-2_Smoe LNLSRNEFLGDFPIW--------------------------------------------- IRAKf_d-1_Smoe LNGSKNAFSGGLPDRQ-------------------------------------------- IRAKf_d-2_Smoe LNGSKNAFSGGLPDRQ-------------------------------------------- IRAKf_g_Smoe ------------------------------------------------------------ IRAKf_m-2_Smoe LNLANNQLYGRIPENI-------------------------------------------- IRAKf_g-1_Smoe ------------------------------------------------------------ IRAKf_m-1_Smoe LNLANNQLYGRIPENI-------------------------------------------- IRAKf_g-2_Smoe ------------------------------------------------------------ IRAKf_n-2_Smoe FNVSRNSLSGDVLPRRSIECNDTQEPVVYPSFCSGRPFCGKRRSETCLSSGLIVVHDISG IRAKf_n-1_Smoe FNVSRNSLSGGVPPRRSIECNDTQEPVVYPSFCSGRPFCGKRRSETCLSSGLIVVHDLSG IRAKf_a_Smoe LALAMNSFSGGLPVALS-SS---------------------------------------- IRAKf_k-1_Smoe LDLSNNKFSGPFPKNV-------------------------------------------- IRAKf_b_Smoe LALAMNSFSGGLPAALS-SS---------------------------------------- IRAKf_k-2_Smoe -----------------------------------------SYCSSLNY--INVHGNMLN IRAKf_c-1_Smoe -----------------------------------------PPCHALQV--VDISGNRIF IRAKf_c-2_Smoe -----------------------------------------PPCHALQV--VDISGNRIF IRAKf_d-1_Smoe ---------------------------------------GDDGCRSLEV--LDLSYNSFE IRAKf_d-2_Smoe ---------------------------------------GDDGCRSLEV--LDLSYNSFE IRAKf_g_Smoe ------------------------------------------------------------ IRAKf_m-2_Smoe -----------------------------------------SSCNALNY--LNVHGNRLN IRAKf_g-1_Smoe ------------------------------------------------------------ IRAKf_m-1_Smoe -----------------------------------------SSCNALNY--LNVHGNRLN IRAKf_g-2_Smoe ------------------------------------------------------------ IRAKf_n-2_Smoe NNFSGPVPAPLIGDELLEQEPVYELLMSENRLAGNIPSSFFAFCGRFKAFMANLSDNQIS IRAKf_n-1_Smoe NNFSGPVPAPLIGDELLEQEPVYELLMSENRLAGNISSSFFAFCGRFKAFMANLSDNQIS IRAKf_a_Smoe --------------------------------------NSSSACKVIQS--LDLSRNSLE IRAKf_k-1_Smoe -----------------------------------------SYCSSLNY--INVHGNMLN IRAKf_b_Smoe --------------------------------------NSSSACKVIQS--LDLSRNSLE IRAKf_k-2_Smoe GTVPP-ELQDLGSLTYLNLSSNSFSGRIPEEL-GHIVNLDTMDLSENILTGHIPRSIGNL IRAKf_c-1_Smoe GEVPS-RIAQCSSLQHLNVGWNVLSGGIPGQI-SQLQRLMFLDLSHNQLQGGIPSTFTNM IRAKf_c-2_Smoe GEVPS-RIAQCSSLQHLNVGWNVLSGGIPGQI-SQLQRLMFLDLSHNQLQGGIPSTFTNM IRAKf_d-1_Smoe GPIPS-NFGECQELSLINLSHNRFSSPIPDAI-GKLAFLVSLDLSSNAMHGSIPQALTQA IRAKf_d-2_Smoe GPIPS-NFGECQELSLINLSHNRFSSPIPDAI-GKLAFLVSLDLSSNAMHGSIPQALTQA IRAKf_g_Smoe ------------------------------------------------------------ IRAKf_m-2_Smoe GSIPP-QLKKLDSLTYLNLSSNLFSGSIPDDF-GHIVNLDTLDVSDNYISGSIPSSVGDL IRAKf_g-1_Smoe ------------------------------------------------------------ IRAKf_m-1_Smoe GSIPP-QLKKLDSLTYLNLSSNLFSGSIPDDF-GHIVNLDTLDVSDNYISGSIPSSVGDL IRAKf_g-2_Smoe ------------------------------------------------------------ IRAKf_n-2_Smoe GELSGQDIGGCKSLVQFSASNNLIEEALPKEL-GTLGNLSLLDLSRNRLSGSIPGELGEL IRAKf_n-1_Smoe GELSGQDIGGCKSLVQFSASNNLIEEALPKEL-GTLGNLSLLDLSRNRLSGSIPGELGEL IRAKf_a_Smoe GEIPP-QVSGCQHLRSLNLGQNGLSGSIPEELVAGLSELSSLDLSSNFLTGYIPRSFGGS IRAKf_k-1_Smoe GTVPP-ELQDLGSLTYLNLSSNSFSGRIPEEL-GHIVNLDTMDLSENILTGHIPRSIGNL IRAKf_b_Smoe GEIPP-QVSGCQHLRSLNLGQNGLSGNIPEELVAGLSELSSLDLGSNFLTGYIPRSFGGS IRAKf_k-2_Smoe EHLLTLVLKHNKLTGGIPSEFGSLKSIYAMDLSENNLSGSIPPELGQLQTLNALLLEKNS IRAKf_c-1_Smoe SSLTVLKLAKNLLVGNIPKAISKCERLVELDLSSNRLSGSIPGALSRLNFLQSLDLAWNN IRAKf_c-2_Smoe SSLTVLKLAKNLLVGNIPKAISKCERLVELDLSSNRLSGSIPGALSRLNFLQSLDLAWNN IRAKf_d-1_Smoe RFLIELKLSSNDLSGTIPRSLNNLTFLKTLLLGHNMLQGSIPAEVGRLTHLERLDLSFNN IRAKf_d-2_Smoe RFLIELKLSSNDFSGTIPRSLNNLTYLKTLLLGHNMLQGSIPAEVGRLTHLERLDLSFNN IRAKf_g_Smoe ---------------------GNCTRLRALYLKNNYLGGTIPKEFGRLASLRILDVSSNS IRAKf_m-2_Smoe EHLLTLILRNNDISGKIPSEFGNLRSIDLLDLSQNKLSGNIPPELGQLQTLNTLFLQHNK IRAKf_g-1_Smoe ---------------------GNCSDLRAVYLRDNLLSGSLPAELGRLKNLKVFDVSENS IRAKf_m-1_Smoe EHLLTLILRNNDISGKIPSEFGNLRSIDLLDLSQNKLLGNIPPELGQLQTLNTLFLQHNK IRAKf_g-2_Smoe ---------------------GNCSDLRAVYLRDNLLSGSLPAELGRLKNLKVFDVSENS IRAKf_n-2_Smoe QMLTSLFLANNSLVGDIPEKLGQASSLSLLDLSGNTLNGTIPSSLANLSHLEYLLLNNND IRAKf_n-1_Smoe QMLTSLFLANNSLVGDIPENLGQASSLSLLDLSGNTLHGTIPSSLANLSHLEYLLLNNND IRAKf_a_Smoe PSLETLKLDDNALVGIIPEGLGNCSSLRYLDLSQNNLTGGIPVELADLSSLQSLDLSSNH IRAKf_k-1_Smoe EHLLTLVLKHNKLTGGIPSEFGSLKSIYAMDLSENNLSGSIPPELGQLQTLNALLLEKNS IRAKf_b_Smoe PSLETLKLDDNALVGIIPEELGNCSSLRYLDLSQNNLTGGIPVELADLSSLQSLDLSSNH .. : : * * * * :* .. * *. : : * IRAKf_k-2_Smoe LSGSIPPQLGNCFSLSTLKSTALWWIH-----------ETNVQRLQEEVIWYIKSLFF-- IRAKf_c-1_Smoe LTGPIPKELVKLESLSSLDVSHNHLDGPIPKGGVF-NLVNR---T-----AFQGNSGL-- IRAKf_c-2_Smoe LTGPIPKELVKLESLSSLDVSHNHLDGPIPKGGVF-NLVNR---T-----AFQGNSGL-- IRAKf_d-1_Smoe ITGSIPIQLGDLSHLVLFNVSYNNLTGFIPRRGVL-QRFDR---S-----SYIGNTFL-- IRAKf_d-2_Smoe ITGSIPIQLGDLSHLVLFNVSYNNLTGFIPRRGVL-QRFDR---S-----SYIGNTFL-- IRAKf_g_Smoe LTGSVPDVLGDLKQLVFLNVSTNALIGEIPSNGVL-SNFSQ---H-----SFLDNLGL-- IRAKf_m-2_Smoe LSGAIPVQLTNCFSLNILNVSYNNLSGEVPSGTIF-SKFTP---D-----SYIGNSQL-- IRAKf_g-1_Smoe LTGPIPASMERLNDLVFLNVSNNFLTGSVTG---L-AKFSN---R-----SFFGNPGL-- IRAKf_m-1_Smoe LSGAIPVQLTNCFSLNILNVSYNNLSGEVPSGTIF-SKFTP---D-----SYIGNSQL-- IRAKf_g-2_Smoe LTGPIPASMERLNDLVFLNVSNNFLTGSVTG---L-AKFSN---R-----SFFGNPGL-- IRAKf_n-2_Smoe FSGTIPPVLSDITSLVAVNLAFNNFSGSVPSSGSWVGMCDK---E-----HFQGNPYLKP IRAKf_n-1_Smoe FSGTIPPVLSDITSLVAVNLAFNNFSGSVPSSGSWVGMCDK---E-----HFQGNPYLKP IRAKf_a_Smoe LTGQIPTSFAQLQNLSLFNVSHNSLAGPIPSDGAF-PLLDP---S-----SFAGNAHL-- IRAKf_k-1_Smoe LSGSIPPQLGNCFSLSTLNLSYNNLSGEIPASSIF-NRFSFDRHV-----VYVGNLQL-- IRAKf_b_Smoe LTGQIPTSFAQLQNLSLFNVSHNSLAGPIPSDGAF-PLLDP---S-----SFAGNAHL-- ::* :* : * .. : : . : IRAKf_k-2_Smoe FHLAFYSS-IF------------------------FFH--LRVETMGASAILGISIGSMC IRAKf_c-1_Smoe CGAALDVACSTVPKPI-VLNPNASSDTAGILQSGGHRG--KNKIVLSVSAIIAISAAAVI IRAKf_c-2_Smoe CGAALDVACSTVPKPI-VLNPNASSDTAGILQSGGHRG--KNKIVLSVSAIIAISAAAVI IRAKf_d-1_Smoe CGPPLSLRCTPMVWPGPALSPTL------------E--GGGKTHVLTPYTIAAIVAAILV IRAKf_d-2_Smoe CGPPLSLRCTPMVWPGPALSPTL------------E--GGGKTHVLTPYTIAAIVAAILV IRAKf_g_Smoe CGAQVNTSCRMAT-P-R-----------------RKTA--NYSNGLWISALGTVAISLFL IRAKf_m-2_Smoe CGTSTKTVCG-------------------------YRS--KQSNTIGATAIMGIAIAAIC IRAKf_g-1_Smoe CGQQLNKSCEVGK-S-V---------------NGSKMS--KLSRNLLISALGTVTASLLF IRAKf_m-1_Smoe CGTSTKTVCG-------------------------YRS--KQSNTIGATAIMGIAIAAIC IRAKf_g-2_Smoe CGQQLNKSCEVGK-S-V---------------NGSKMS--KLSRNLLISALGTVTASLLF IRAKf_n-2_Smoe CPTSLAAFGPGYME--ENLDPVAA--------PQ----DPPAGGGLSVVVIVAITSGCAV IRAKf_n-1_Smoe CPTSLAAFGPGYME--ENLDPVAA--------PQ----DPPAGGGLSVVVIVAITSGCAV IRAKf_a_Smoe CGASLSIDCPAIPKPI-VLNPNATTTPDPIISSSDHRSPPSSKIVLSVSAIIAISAAAVI IRAKf_k-1_Smoe CGGSTKPMCNV------------------------YRK--RSSETMGASAILGISIGSMC IRAKf_b_Smoe CGASLSIACPAIPKPI-VLNPNATTTPDPIISSSDHRSPPSSKIVLSVSAIIAISAAAVI : .: : . IRAKf_k-2_Smoe -L-LLVFIFLGIRWNQPKGFVK-------------ASKNSSQ-SPPSLVVLHMDMSCHTY IRAKf_c-1_Smoe ALGIVVVSVLNIRAQQAAPAAALKNNFFMADHNSSPSSSSEDLAIGKLVMFTDG-NDTKS IRAKf_c-2_Smoe ALGIVVVSVLNIRAQQAAPAAALKNNFFMADHNSSPSSSSEDLAIGKLVMFTDG-NDTKS IRAKf_d-1_Smoe ALGVFIVVILNIKVL-TRPKKTPA-EVL-VYESTPPSPDSSTGVIGKLVLFNPN-IPSKY IRAKf_d-2_Smoe ALGVFIVVILNIKVL-TRPKKTPA-EVL-VYESTPPSPDSSTGVIGKLVLFNPN-IPSKY IRAKf_g_Smoe VLLCFWGVFLYNKFGS---KQ-----------H-LAQV-TS-ASSAKLVLFHGD-LPYTS IRAKf_m-2_Smoe -L-VLLLVFLGIRLNHSKPFAK-------------GSSKTGQ-GPPNLVVLHMDMACHSY IRAKf_g-1_Smoe ALVCFWGFLFYNKFNAT--KA-----------C-IPQQ-PE-PSAAKLVLFHGG-LPYTL IRAKf_m-1_Smoe -L-VLLLVFLGIRLNHSKPFAK-------------GSSKTGQ-GPPNLVVLHMDMACHSY IRAKf_g-2_Smoe ALVCFWGFLFYNKFNAT--KA-----------C-IPQQ-PE-PSAAKLVLFHGG-LPYTL IRAKf_n-2_Smoe AVVLLVLVLLVQCTKQR-----------------VPRPPGNRGGRKEVVIFTNIGFRFTY IRAKf_n-1_Smoe AVVLLVLVLLVQCTKQR-----------------VPRPPRNRGGRKEVVIFTNIGFRFTY IRAKf_a_Smoe ALGIVVVSLLNLRSH-PRPRAS----FYVVD-SLPGSSPSEDLAIGKLVMFTDD-SDSRD IRAKf_k-1_Smoe -L-LLVFIFLGIRWNQPKGFVK-------------ASKNSSQ-SPPSLVVLHMDMSCHTY IRAKf_b_Smoe ALGIVVVSLLNLRSH-PRPRAS----FYVVD-SLPGSSPSEDLAIGKLVMFTDD-SDSRD : . .: .:*:: IRAKf_k-2_Smoe DDIMRITD-NLHERFLVGRGASSSVYKCTLKNGKKVAIKRLYN-H-YPQNVHEFETELAT IRAKf_c-1_Smoe EELLPSAHSLLNKEQEIGRGGFGVVYRAAISDGRTFAVKKLVTAG-LVKSQLEFEKEVQQ IRAKf_c-2_Smoe EELLPSAHSLLNKEQEIGRGGFGVVYRAAISDGRTFAVKKLVTAG-LVKSQLEFEKEVQQ IRAKf_d-1_Smoe ENWQEGTKALVDKDCVIGYGPLGTVYKAVVDGGVALAVKKLSSLG-QITSQEAFEREIAI IRAKf_d-2_Smoe ENWQEGTKALVDKDCVIGYGPLGTVYKAVVDGGVALAVKKLSSLG-QITSQEAFEREIAI IRAKf_g_Smoe ADIVKKIN-LLGENDIIGCGGFGTVYKLVMDDGNMFAVKRIAKGGF--GSERLFERELEI IRAKf_m-2_Smoe DDVMRITD-NLNERFIIGRGASSTVYKCSLKNGKTVAIKKLYN-H-FPQNIHEFETELET IRAKf_g-1_Smoe KEVITKIE-RLDYKDIIGAGGFGTVYKLCMDEDCVFAVKKVGRSSDGSISERRLEKELDV IRAKf_m-1_Smoe DDVMRITD-NLNERFIIGRGASSTVYKCSLKNGKTVAIKKLYN-H-FPQNIHEFETELET IRAKf_g-2_Smoe KEVITKIE-RLDYKDIIGAGGFGTVYKLCMDEDCVFAVKKVGRSSDGSISEKRLEKELDV IRAKf_n-2_Smoe ENVVRATG-NFSVDYLIGNGGFGATYKAEMMPGLVVAVKRLSI-G-RFQGVQQFDTEIRT IRAKf_n-1_Smoe ENVVRATG-NFSVDYLIGNGGFGATYKAEMMPGLVVAVKRLSI-G-RFQGVQQFDTEIRT IRAKf_a_Smoe EDLLPTAQALLNKNSEIGRGGFGTVYKATLAAGRTVAVKKLSVPG-MVETQDEFEKRVQF IRAKf_k-1_Smoe DDIMRITD-NLHERFLVGRGASSSVYKCTLKNGKKVAIKRLYN-H-YPQNVHEFETELAT IRAKf_b_Smoe EDLLPTAQALLNKNSEIGRGGFGTVYKATLAAGRTVAVKKLSVPG-MVETQDEFEKRVQF : . :* * . .*: : . .*:*:: :: .: IRAKf_k-2_Smoe LGHIKHRNLVSLYGYSLSSAGNLLFYDFMDNGSLWDILHGPVR-KVTLDWDARLIIALGA IRAKf_c-1_Smoe LGKIEHPNLVALQGYYWTSRMQLLIYDFVPNGSLYSRLHERTFGEPPLSWSERFKIAQGT IRAKf_c-2_Smoe LGKIEHPNLVALQGYYWTSRMQLLIYDFVPNGSLYSRLHERTFGEPPLSWSERFKIAQGT IRAKf_d-1_Smoe LKNVKHRNVVTLEGYYWSPPTKLLLTEYLPNDSLFHHLHQRMEGQLPLPWWRRFKIALGA IRAKf_d-2_Smoe LKNVKHRNVVTLEGYYWSPPTKLLLTEYLPNDSLFHHLHQRMEGQLPLPWWRRFKIALGA IRAKf_g_Smoe LGSIKHRNLVNLRGYCNSGSARLLIYDFLSHGSLDDLLHEREPHKPSLNWNHRMKAAIGS IRAKf_m-2_Smoe LGHIKHRNLVGLHGYSLSPAGNLLFYDYLENGSLWDVLHGPVR-KVKLDWDTRLKIALGA IRAKf_g-1_Smoe LGSIQHRNLVSLKGYCNAPTARLLITDFMPLGSLDEHLHERHAKDSLMTWEARLNIAIGT IRAKf_m-1_Smoe LGHIKHRNLVGLHGYSLSPAGNLLFYDYLENGSLWDVLHGPVR-KVKLDWDTRLKIALGA IRAKf_g-2_Smoe LGSIQHRNLVSLKGYCNAPTARLLITDFMPLGSLDEHLHERHAKDSLMTWEARLNIAIGT IRAKf_n-2_Smoe LGRIQHSNLVKLIGYHASEGEMFLIYNYFPRGNLESFIHNRSRG--EISWAVVHRIAMGI IRAKf_n-1_Smoe LGRIQHSNLVKLIGYHASEGEMFLIYNYFPRGNLESFIHNRSRG--EMSWAVVHRIALGI IRAKf_a_Smoe LGKIQHENLVNFQGYYFTPKLQLLIYDFVPNGNLHSKLHEQ----SVLPWELRFKVALGA IRAKf_k-1_Smoe LGHIKHRNLVSLYGYSLSSAGNLLFYDFMDNGSLWDILHGPVR-KVTLDWDARLIIALGA IRAKf_b_Smoe LGKIQHENLVNFQGYYFTPKLQLLIYDFVPNGNLHSKLHEQ----SVLPWELRFKVALGA * ::* *:* : ** : :*: ::. ..* :* : * * * IRAKf_k-2_Smoe AQGLEYLHHNCSPRIIHRDVKSSNILLDERFEVHLSDFGIAKSICSASTHTS-TYVMGTI IRAKf_c-1_Smoe AMGLSHLHHSCQPQVIHYDLKSNNILLGVDNRPLISDYGLANLLPVLDRYAISSKFQGAL IRAKf_c-2_Smoe AMGLSHLHHSCQPQVIHYDLKSNNILLGVDNRPLISDYGLANLLPVLDRYAISSKFQGAL IRAKf_d-1_Smoe ARGLAYLHHDCRPQVLLFNLKSTNILLDDEFEPHISDYGLRRLLPKLDTYMTDRKLELAV IRAKf_d-2_Smoe ARGLAYLHHDCRPQVLLFNLKSTNILLDDEFEPHISDYGLRRLLPKLDTYMTDRKLELAV IRAKf_g_Smoe ARGISYLHHDCSPRIVHRDIKSSNILLDSNFEPHVSDFGLAKLLNENQSHMT-TIVAGTF IRAKf_m-2_Smoe AQGLAYLHHDCSPRIIHRDVKSSNILLDENFDAHISDFGIAKSICPTKTHTS-TFVLGTI IRAKf_g-1_Smoe ARGLGHLHHRCVPPIIHRDIKSSNVLLDRNLEACVSDFGLARLLEENDSQVT-TIVAGTF IRAKf_m-1_Smoe AQGLAYLHHDCSPRIIHRDVKSSNILLDENFDAHISDFGIAKSICPTKTHTS-TFVLGTI IRAKf_g-2_Smoe ARGLGHLHHRCVPPIIHRDIKSSNVLLDRNLEACVSDFGLAKLLEENDSQVT-TIVAGTF IRAKf_n-2_Smoe AEALAYLHDECQPRVLHRDIKPSNILLDNNLTAFLADFGLARLLGASETHAT-TDVAGTF IRAKf_n-1_Smoe AEALAYLHDECQPRVLHRDIKPSNILLDNNLTAFLADFGLARLLGASETHAT-TDVAGTF IRAKf_a_Smoe AQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAKLLHSRDRFVVMNKLQSSL IRAKf_k-1_Smoe AQGLEYLHHNCSPRIIHRDVKSSNILLDERFEVHLSDFGIAKSICSASTHTS-TYVMGTI IRAKf_b_Smoe AQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAKLLHSRDRFVVMNKLQSSL * .: :**. * * :: :.*..*:**. ::*:*: . : . . :. IRAKf_k-2_Smoe GYIDPEYA-RTSRLNEKSDVYSFGIVLLELITRQKAVDD-------EKNLHQWVLSHVNN IRAKf_c-1_Smoe GYMAPEFASQSSKVTEKCDVYGFGIILLELVTGRRPVEYMEED---VVILCDYVRALLNE IRAKf_c-2_Smoe GYMAPEFASQSSKVTEKCDVYGFGIILLELVTGRRPVEYMEED---VVILCDYVRALLNE IRAKf_d-1_Smoe GYVAPEMAVQNLRLTDKCDVYSFGVVLLELVTGRRPVQNLETD---AVVLCEYAKAAFEQ IRAKf_d-2_Smoe GYVAPEMAVQNLRLTDKCDVYSFGVVLLELVTGRRPVQNLETD---AVVLCEYAKAAFEQ IRAKf_g_Smoe GYLAPEYM-QSGRVTEKSDVYSFGVVLLELLSGKRPTDPGFVA--KGLNVVGWVNALIKE IRAKf_m-2_Smoe GYIDPEYA-RTSRLNEKSDVYSYGIVLLELITGLKAVDD-------ERNLHQWVLSHVNN IRAKf_g-1_Smoe GYLAPEYM-QSGRATEKSDVYSYGVVLLELLSGKRPTDVCFTA--KGLNIVGWASAMMLQ IRAKf_m-1_Smoe GYIDPEYA-RTSRLNEKSDVYSYGIVLLELITGLKAVDD-------ERNLHQWVLSHVNN IRAKf_g-2_Smoe GYLAPEYM-QSGRATEKSDVYSYGVVLLELLSGKRPTDVCFTA--KGLNIVGWASAMMLQ IRAKf_n-2_Smoe GYVAPEYA-MTCRVSDKADVYSYGVVLLELLSGKKALDPAFSDYGHGFTIVGWACLLIGQ IRAKf_n-1_Smoe GYVAPEYA-MTCRVSDKADVYSYGVVLLELLSGKKALDPAFSDYGHGFTIVGWACLLIGQ IRAKf_a_Smoe GYLAPECGCESFKVTEKCDVYGFGVVLLELITGKPPVEYLEND---VVILCDFVRSLADD IRAKf_k-1_Smoe GYIDPEYA-RTSRLNEKSDVYSFGIVLLELITRQKAVDD-------EKNLHQWVLSHVNN IRAKf_b_Smoe GYLAPECGCESFKVTEKCDVYGFGVVLLELITGKPPVEYLEND---VVILCDFVRSLADD **: ** . : .:*.***.:*::****:: . : : :. : IRAKf_k-2_Smoe KSVMEIVDQEVKDTCTDPNAIQKLIRLALLCAQKFPAQRPTMHDVVNVILTLLPPPT--- IRAKf_c-1_Smoe GRGMSCVEPSLEA-CP-EDEVLPVIKLGLICSSPLPSNRPSMAEVVQILELVRPLPG--- IRAKf_c-2_Smoe GRGMSCVEPSLEA-SP-EDEVLPVIKLGLICSSPLPSNRPSMAEVVQILELVRPLPG--- IRAKf_d-1_Smoe GRGLQCLDHEMSS-FP-EAEIMQVFRIGLLCTAQDPSRRPSMAAVVQMMEMLSINSNNDF IRAKf_d-2_Smoe GRGLQCLDHEMSS-FP-EAEIMQVFRIGLLCTAQDPSRRPSMAAIVQMMEMLS------- IRAKf_g_Smoe NKQKEVFDSKCEG-GS-RESMECVLQIAAMCIAPLPDDRPTMDNVVKMLESEMM------ IRAKf_m-2_Smoe NTVMEVIDAEIKDTCQDIGTVQKMIRLALLCAQKQAAQRPAMHDVANVLFSLSPVPA--- IRAKf_g-1_Smoe NRCLEIFDPHCRG-AQ-LESMEAVLEVAAMCIHPRPECRPSMATVAEILQEHHHS----- IRAKf_m-1_Smoe NTVMEVIDAEIKDTCQDIGTVQKMIRLALLCAQKQAAQRPAMHDVANVLFSLSPVPA--- IRAKf_g-2_Smoe NRCLEIFDPHCRG-AQ-LESMEAVLEVAAMCIHPRPECRPSMATVVEILQEHHHS----- IRAKf_n-2_Smoe GRAHEVFIVELWEMGP-EAFLLETLKLAVMCTVDSLTVRPTMRQVVDRLRHMDQSS---- IRAKf_n-1_Smoe GRAHEVFIVELWEMGP-EAFLLETLKLAVMCTVDSLTVRPTMRQVVDRLRHMDQSS---- IRAKf_a_Smoe GKPLLCVDPKMVV-YP-EEEVMTLIKLGLVCTSPVPANRPSMTEVVQILELIKPLA---- IRAKf_k-1_Smoe KSVMEIVDQEVKDTCTDPNAIQKLIRLALLCAQKFPAQRPTMHDVVNVILTLLPPPS--- IRAKf_b_Smoe GKPLLCVDPKMVV-YP-EEEVMTLIKLGLVCTSPVPANRPSMTEVVQILELIKPLA---- . : :.:. :* **:* :.. : IRAKf_k-2_Smoe ------------------------------------VKKSSAGAANAAANAAVDSSANAG IRAKf_c-1_Smoe ------------------------------------IDNSNS------------------ IRAKf_c-2_Smoe ------------------------------------IDNSNS------------------ IRAKf_d-1_Smoe YDISAVDGFFIGTGMSITGSGRGLTCRAEASTCPPENTNGNVCTSP-----------NRD IRAKf_d-2_Smoe ------------------------------------------------------------ IRAKf_g_Smoe ------------------------------------------------------------ IRAKf_m-2_Smoe ------------------------------------LSKKSVSSNP-------------- IRAKf_g-1_Smoe ------------------------------------------------------------ IRAKf_m-1_Smoe ------------------------------------LSKKSVSSNP-------------- IRAKf_g-2_Smoe ------------------------------------------------------------ IRAKf_n-2_Smoe ------------------------------------------------------------ IRAKf_n-1_Smoe ------------------------------------------------------------ IRAKf_a_Smoe ------------------------------------------------------------ IRAKf_k-1_Smoe ------------------------------------VKKSSAGAANAAANAAVDSAANAG IRAKf_b_Smoe ------------------------------------------------------------ IRAKf_k-2_Smoe GANRRYVDDY------VDSKHRDNLSASSTTSGGHLFVKFGEVISQG IRAKf_c-1_Smoe -----------------------------------I-----SRSSSS IRAKf_c-2_Smoe -----------------------------------I-----SRSSSS IRAKf_d-1_Smoe DPNSQYAQNVRASCPDAYSWSGDNTKTFATGTGGTF-----TITFCP IRAKf_d-2_Smoe ----------------------------------------------M IRAKf_g_Smoe ------------------------LSP-SPS-DF---Y----ESSSE IRAKf_m-2_Smoe -NQRRYIDDY------AESKHADNLSASSTNSGGHLFMKFGEVISQD IRAKf_g-1_Smoe ------------------------LCS-STEEDGSCAS---EFSLKL IRAKf_m-1_Smoe -NQRRYIDDY------AESKHADNLSASSTNSGGHLFMKFGEVISQD IRAKf_g-2_Smoe ------------------------LCS-STEEDGSCAS---EFSLKL IRAKf_n-2_Smoe -------------------------------------------LPFS IRAKf_n-1_Smoe -------------------------------------------LPFS IRAKf_a_Smoe -------------------------------------------DNRS IRAKf_k-1_Smoe GANRRYVDDY------VDSKHRDNLSASSTTSGGHLFVKFGEVISQG IRAKf_b_Smoe -------------------------------------------DNRS